-- dump date   	20140619_021030
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
99598000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
99598000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
99598000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598000004	Walker A motif; other site
99598000005	ATP binding site [chemical binding]; other site
99598000006	Walker B motif; other site
99598000007	arginine finger; other site
99598000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
99598000009	DnaA box-binding interface [nucleotide binding]; other site
99598000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
99598000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
99598000012	putative DNA binding surface [nucleotide binding]; other site
99598000013	dimer interface [polypeptide binding]; other site
99598000014	beta-clamp/clamp loader binding surface; other site
99598000015	beta-clamp/translesion DNA polymerase binding surface; other site
99598000016	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
99598000017	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
99598000018	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
99598000019	Surface antigen; Region: Bac_surface_Ag; pfam01103
99598000020	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598000021	active site
99598000022	ATP binding site [chemical binding]; other site
99598000023	substrate binding site [chemical binding]; other site
99598000024	activation loop (A-loop); other site
99598000025	GM-CSF/IL-2 inhibition factor; Provisional; Region: PHA02668; cl17645
99598000026	Mgc45594 gene product and other MDR family members; Region: Mgc45594_like; cd08250
99598000027	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
99598000028	NADP binding site [chemical binding]; other site
99598000029	dimer interface [polypeptide binding]; other site
99598000030	SnoaL-like domain; Region: SnoaL_2; pfam12680
99598000031	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
99598000032	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
99598000033	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
99598000034	putative active site [active]
99598000035	NACHT domain; Region: NACHT; pfam05729
99598000036	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
99598000037	Walker A motif; other site
99598000038	ATP binding site [chemical binding]; other site
99598000039	Walker B motif; other site
99598000040	HEAT repeats; Region: HEAT_2; pfam13646
99598000041	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
99598000042	tetramer interface [polypeptide binding]; other site
99598000043	dimer interface [polypeptide binding]; other site
99598000044	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
99598000045	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
99598000046	Walker A motif; other site
99598000047	ATP binding site [chemical binding]; other site
99598000048	Walker B motif; other site
99598000049	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
99598000050	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
99598000051	active site
99598000052	homodimer interface [polypeptide binding]; other site
99598000053	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
99598000054	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
99598000055	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
99598000056	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99598000057	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
99598000058	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
99598000059	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
99598000060	cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156
99598000061	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
99598000062	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
99598000063	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
99598000064	inhibitor-cofactor binding pocket; inhibition site
99598000065	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598000066	catalytic residue [active]
99598000067	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598000068	GAF domain; Region: GAF; pfam01590
99598000069	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598000070	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598000071	dimer interface [polypeptide binding]; other site
99598000072	phosphorylation site [posttranslational modification]
99598000073	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
99598000074	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
99598000075	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
99598000076	SmpB-tmRNA interface; other site
99598000077	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99598000078	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598000079	active site
99598000080	phosphorylation site [posttranslational modification]
99598000081	intermolecular recognition site; other site
99598000082	dimerization interface [polypeptide binding]; other site
99598000083	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598000084	DNA binding residues [nucleotide binding]
99598000085	dimerization interface [polypeptide binding]; other site
99598000086	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
99598000087	Low molecular weight phosphatase family; Region: LMWPc; cd00115
99598000088	active site
99598000089	hypothetical protein; Validated; Region: PRK00153
99598000090	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
99598000091	FAD binding domain; Region: FAD_binding_4; pfam01565
99598000092	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
99598000093	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
99598000094	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
99598000095	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
99598000096	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
99598000097	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
99598000098	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
99598000099	active site
99598000100	(T/H)XGH motif; other site
99598000101	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
99598000102	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
99598000103	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
99598000104	thiamine monophosphate kinase; Provisional; Region: PRK05731
99598000105	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
99598000106	ATP binding site [chemical binding]; other site
99598000107	dimerization interface [polypeptide binding]; other site
99598000108	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598000109	putative active site [active]
99598000110	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
99598000111	active site
99598000112	elongation factor P; Validated; Region: PRK00529
99598000113	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
99598000114	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
99598000115	RNA binding site [nucleotide binding]; other site
99598000116	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
99598000117	RNA binding site [nucleotide binding]; other site
99598000118	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
99598000119	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
99598000120	carboxyltransferase (CT) interaction site; other site
99598000121	biotinylation site [posttranslational modification]; other site
99598000122	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
99598000123	putative DNA binding site [nucleotide binding]; other site
99598000124	putative Zn2+ binding site [ion binding]; other site
99598000125	Sporulation and spore germination; Region: Germane; pfam10646
99598000126	prolyl-tRNA synthetase; Provisional; Region: PRK09194
99598000127	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
99598000128	dimer interface [polypeptide binding]; other site
99598000129	motif 1; other site
99598000130	active site
99598000131	motif 2; other site
99598000132	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
99598000133	putative deacylase active site [active]
99598000134	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
99598000135	active site
99598000136	motif 3; other site
99598000137	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
99598000138	anticodon binding site; other site
99598000139	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
99598000140	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598000141	PAS domain; Region: PAS_9; pfam13426
99598000142	putative active site [active]
99598000143	heme pocket [chemical binding]; other site
99598000144	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
99598000145	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99598000146	metal binding site [ion binding]; metal-binding site
99598000147	active site
99598000148	I-site; other site
99598000149	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
99598000150	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598000151	oligomeric interface; other site
99598000152	putative active site [active]
99598000153	homodimer interface [polypeptide binding]; other site
99598000154	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
99598000155	dimer interface [polypeptide binding]; other site
99598000156	[2Fe-2S] cluster binding site [ion binding]; other site
99598000157	NifT/FixU protein; Region: NifT; pfam06988
99598000158	NifZ domain; Region: NifZ; pfam04319
99598000159	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
99598000160	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
99598000161	active site
99598000162	catalytic residues [active]
99598000163	metal binding site [ion binding]; metal-binding site
99598000164	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
99598000165	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
99598000166	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
99598000167	trimer interface [polypeptide binding]; other site
99598000168	active site
99598000169	substrate binding site [chemical binding]; other site
99598000170	CoA binding site [chemical binding]; other site
99598000171	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
99598000172	Transposase; Region: DEDD_Tnp_IS110; pfam01548
99598000173	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
99598000174	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598000175	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598000176	active site
99598000177	ATP binding site [chemical binding]; other site
99598000178	substrate binding site [chemical binding]; other site
99598000179	activation loop (A-loop); other site
99598000180	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598000181	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598000182	structural tetrad; other site
99598000183	Putative addiction module component; Region: Unstab_antitox; pfam09720
99598000184	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
99598000185	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
99598000186	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598000187	putative active site [active]
99598000188	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
99598000189	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
99598000190	putative NAD(P) binding site [chemical binding]; other site
99598000191	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
99598000192	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598000193	FeS/SAM binding site; other site
99598000194	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
99598000195	4Fe-4S binding domain; Region: Fer4; cl02805
99598000196	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
99598000197	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
99598000198	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
99598000199	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99598000200	catalytic residue [active]
99598000201	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
99598000202	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
99598000203	trimerization site [polypeptide binding]; other site
99598000204	active site
99598000205	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
99598000206	Poxvirus A3L Protein; Region: Pox_A3L; cl17407
99598000207	NifU-like domain; Region: NifU; pfam01106
99598000208	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
99598000209	apolar tunnel; other site
99598000210	heme binding site [chemical binding]; other site
99598000211	dimerization interface [polypeptide binding]; other site
99598000212	nitrogenase reductase; Reviewed; Region: PRK13236
99598000213	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
99598000214	Nucleotide-binding sites [chemical binding]; other site
99598000215	Walker A motif; other site
99598000216	Switch I region of nucleotide binding site; other site
99598000217	Fe4S4 binding sites [ion binding]; other site
99598000218	Switch II region of nucleotide binding site; other site
99598000219	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
99598000220	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
99598000221	MoFe protein alpha/beta subunit interactions; other site
99598000222	Alpha subunit P cluster binding residues; other site
99598000223	FeMoco binding residues [chemical binding]; other site
99598000224	MoFe protein alpha subunit/Fe protein contacts; other site
99598000225	MoFe protein dimer/ dimer interactions; other site
99598000226	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
99598000227	active site
99598000228	Restriction endonuclease BsobI; Region: Endonuc-BsobI; pfam09194
99598000229	DNA methylase; Region: N6_N4_Mtase; cl17433
99598000230	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
99598000231	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
99598000232	putative active site [active]
99598000233	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
99598000234	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
99598000235	Cytochrome P450; Region: p450; pfam00067
99598000236	Protein kinase domain; Region: Pkinase; pfam00069
99598000237	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598000238	active site
99598000239	ATP binding site [chemical binding]; other site
99598000240	substrate binding site [chemical binding]; other site
99598000241	activation loop (A-loop); other site
99598000242	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
99598000243	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
99598000244	Anti-sigma-K factor rskA; Region: RskA; pfam10099
99598000245	RNA polymerase sigma factor; Provisional; Region: PRK12519
99598000246	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99598000247	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99598000248	DNA binding residues [nucleotide binding]
99598000249	CHRD domain; Region: CHRD; pfam07452
99598000250	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
99598000251	active site
99598000252	catalytic residues [active]
99598000253	DNA binding site [nucleotide binding]
99598000254	Int/Topo IB signature motif; other site
99598000255	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
99598000256	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
99598000257	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
99598000258	MoFe protein beta/alpha subunit interactions; other site
99598000259	Beta subunit P cluster binding residues; other site
99598000260	MoFe protein beta subunit/Fe protein contacts; other site
99598000261	MoFe protein dimer/ dimer interactions; other site
99598000262	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
99598000263	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
99598000264	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
99598000265	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
99598000266	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
99598000267	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
99598000268	Protein of unknown function, DUF269; Region: DUF269; pfam03270
99598000269	Rop-like; Region: Rop-like; pfam05082
99598000270	Nitrogen fixation protein NifW; Region: NifW; cl03935
99598000271	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
99598000272	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
99598000273	ATP binding site [chemical binding]; other site
99598000274	substrate interface [chemical binding]; other site
99598000275	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
99598000276	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99598000277	catalytic loop [active]
99598000278	iron binding site [ion binding]; other site
99598000279	FeoA domain; Region: FeoA; pfam04023
99598000280	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
99598000281	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
99598000282	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
99598000283	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
99598000284	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
99598000285	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
99598000286	NADPH bind site [chemical binding]; other site
99598000287	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
99598000288	putative FMN binding site [chemical binding]; other site
99598000289	NADPH bind site [chemical binding]; other site
99598000290	This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063
99598000291	nickel binding site [ion binding]; other site
99598000292	YcfA-like protein; Region: YcfA; pfam07927
99598000293	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
99598000294	T5orf172 domain; Region: T5orf172; pfam10544
99598000295	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
99598000296	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
99598000297	putative active site [active]
99598000298	Protein of unknown function DUF104; Region: DUF104; pfam01954
99598000299	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
99598000300	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
99598000301	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
99598000302	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
99598000303	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598000304	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
99598000305	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
99598000306	iron-sulfur cluster [ion binding]; other site
99598000307	[2Fe-2S] cluster binding site [ion binding]; other site
99598000308	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
99598000309	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
99598000310	Acylphosphatase; Region: Acylphosphatase; pfam00708
99598000311	HypF finger; Region: zf-HYPF; pfam07503
99598000312	HypF finger; Region: zf-HYPF; pfam07503
99598000313	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
99598000314	HupF/HypC family; Region: HupF_HypC; pfam01455
99598000315	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
99598000316	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
99598000317	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
99598000318	active site 1 [active]
99598000319	dimer interface [polypeptide binding]; other site
99598000320	hexamer interface [polypeptide binding]; other site
99598000321	active site 2 [active]
99598000322	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
99598000323	dimer interface [polypeptide binding]; other site
99598000324	ligand binding site [chemical binding]; other site
99598000325	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
99598000326	dimerization interface [polypeptide binding]; other site
99598000327	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
99598000328	ATP binding site [chemical binding]; other site
99598000329	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
99598000330	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
99598000331	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99598000332	DDE superfamily endonuclease; Region: DDE_5; cl17874
99598000333	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
99598000334	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
99598000335	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
99598000336	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
99598000337	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
99598000338	dimer interface [polypeptide binding]; other site
99598000339	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598000340	catalytic residue [active]
99598000341	Uncharacterized conserved protein [Function unknown]; Region: COG1262
99598000342	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
99598000343	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
99598000344	ArsC family; Region: ArsC; pfam03960
99598000345	putative catalytic residues [active]
99598000346	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
99598000347	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
99598000348	Subunit I/III interface [polypeptide binding]; other site
99598000349	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
99598000350	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
99598000351	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
99598000352	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
99598000353	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
99598000354	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
99598000355	4Fe-4S binding domain; Region: Fer4; cl02805
99598000356	Ferredoxin [Energy production and conversion]; Region: COG1146
99598000357	4Fe-4S binding domain; Region: Fer4; pfam00037
99598000358	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598000359	non-specific DNA binding site [nucleotide binding]; other site
99598000360	salt bridge; other site
99598000361	sequence-specific DNA binding site [nucleotide binding]; other site
99598000362	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598000363	putative active site [active]
99598000364	CRISPR-associated protein; Region: DUF3692; pfam12469
99598000365	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
99598000366	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
99598000367	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
99598000368	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
99598000369	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
99598000370	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
99598000371	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
99598000372	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
99598000373	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
99598000374	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
99598000375	nucleotide binding site [chemical binding]; other site
99598000376	NEF interaction site [polypeptide binding]; other site
99598000377	SBD interface [polypeptide binding]; other site
99598000378	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
99598000379	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
99598000380	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
99598000381	putative C-terminal domain interface [polypeptide binding]; other site
99598000382	putative GSH binding site (G-site) [chemical binding]; other site
99598000383	putative dimer interface [polypeptide binding]; other site
99598000384	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
99598000385	N-terminal domain interface [polypeptide binding]; other site
99598000386	dimer interface [polypeptide binding]; other site
99598000387	substrate binding pocket (H-site) [chemical binding]; other site
99598000388	Uncharacterized conserved protein [Function unknown]; Region: COG2135
99598000389	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
99598000390	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598000391	binding surface
99598000392	TPR motif; other site
99598000393	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
99598000394	light-harvesting-like protein 3; Provisional; Region: PLN00014
99598000395	Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351
99598000396	XisI protein; Region: XisI; pfam08869
99598000397	AMIN domain; Region: AMIN; pfam11741
99598000398	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
99598000399	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99598000400	N-terminal plug; other site
99598000401	ligand-binding site [chemical binding]; other site
99598000402	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
99598000403	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
99598000404	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598000405	S-adenosylmethionine binding site [chemical binding]; other site
99598000406	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
99598000407	AMIN domain; Region: AMIN; pfam11741
99598000408	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
99598000409	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99598000410	N-terminal plug; other site
99598000411	ligand-binding site [chemical binding]; other site
99598000412	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
99598000413	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99598000414	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
99598000415	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99598000416	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
99598000417	trimer interface [polypeptide binding]; other site
99598000418	active site
99598000419	cob(I)yrinic acid a,c-diamide adenosyltransferase; Validated; Region: PRK07414
99598000420	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
99598000421	adenylate kinase; Provisional; Region: adk; PRK02496
99598000422	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
99598000423	AMP-binding site [chemical binding]; other site
99598000424	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
99598000425	ribonuclease PH; Reviewed; Region: rph; PRK00173
99598000426	Ribonuclease PH; Region: RNase_PH_bact; cd11362
99598000427	hexamer interface [polypeptide binding]; other site
99598000428	active site
99598000429	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
99598000430	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
99598000431	putative active site [active]
99598000432	Double zinc ribbon; Region: DZR; pfam12773
99598000433	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
99598000434	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
99598000435	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
99598000436	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
99598000437	phosphopeptide binding site; other site
99598000438	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
99598000439	NB-ARC domain; Region: NB-ARC; pfam00931
99598000440	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
99598000441	binding surface
99598000442	TPR motif; other site
99598000443	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598000444	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598000445	binding surface
99598000446	TPR motif; other site
99598000447	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598000448	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598000449	TPR motif; other site
99598000450	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598000451	binding surface
99598000452	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
99598000453	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
99598000454	active site
99598000455	non-prolyl cis peptide bond; other site
99598000456	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
99598000457	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
99598000458	C-terminal domain interface [polypeptide binding]; other site
99598000459	GSH binding site (G-site) [chemical binding]; other site
99598000460	dimer interface [polypeptide binding]; other site
99598000461	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
99598000462	N-terminal domain interface [polypeptide binding]; other site
99598000463	Phycobilisome protein; Region: Phycobilisome; cl08227
99598000464	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
99598000465	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
99598000466	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598000467	motif II; other site
99598000468	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
99598000469	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
99598000470	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
99598000471	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
99598000472	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
99598000473	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
99598000474	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
99598000475	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
99598000476	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
99598000477	TPR repeat; Region: TPR_11; pfam13414
99598000478	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598000479	binding surface
99598000480	TPR motif; other site
99598000481	TPR repeat; Region: TPR_11; pfam13414
99598000482	Tetratricopeptide repeat; Region: TPR_1; pfam00515
99598000483	TPR repeat; Region: TPR_11; pfam13414
99598000484	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598000485	binding surface
99598000486	TPR motif; other site
99598000487	TPR repeat; Region: TPR_11; pfam13414
99598000488	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598000489	binding surface
99598000490	TPR motif; other site
99598000491	TPR repeat; Region: TPR_11; pfam13414
99598000492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598000493	binding surface
99598000494	TPR motif; other site
99598000495	TPR repeat; Region: TPR_11; pfam13414
99598000496	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598000497	binding surface
99598000498	TPR repeat; Region: TPR_11; pfam13414
99598000499	TPR motif; other site
99598000500	TPR repeat; Region: TPR_11; pfam13414
99598000501	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598000502	binding surface
99598000503	TPR motif; other site
99598000504	TPR repeat; Region: TPR_11; pfam13414
99598000505	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
99598000506	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
99598000507	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
99598000508	putative ligand binding site [chemical binding]; other site
99598000509	putative NAD binding site [chemical binding]; other site
99598000510	catalytic site [active]
99598000511	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
99598000512	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
99598000513	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
99598000514	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
99598000515	DNA binding residues [nucleotide binding]
99598000516	dimer interface [polypeptide binding]; other site
99598000517	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082
99598000518	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
99598000519	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
99598000520	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
99598000521	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598000522	putative active site [active]
99598000523	heme pocket [chemical binding]; other site
99598000524	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598000525	dimer interface [polypeptide binding]; other site
99598000526	phosphorylation site [posttranslational modification]
99598000527	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598000528	ATP binding site [chemical binding]; other site
99598000529	Mg2+ binding site [ion binding]; other site
99598000530	G-X-G motif; other site
99598000531	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
99598000532	Low molecular weight phosphatase family; Region: LMWPc; cl00105
99598000533	active site
99598000534	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
99598000535	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
99598000536	DNA binding residues [nucleotide binding]
99598000537	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
99598000538	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99598000539	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
99598000540	Soluble P-type ATPase [General function prediction only]; Region: COG4087
99598000541	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
99598000542	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598000543	dimerization interface [polypeptide binding]; other site
99598000544	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598000545	dimerization interface [polypeptide binding]; other site
99598000546	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598000547	dimerization interface [polypeptide binding]; other site
99598000548	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598000549	dimerization interface [polypeptide binding]; other site
99598000550	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
99598000551	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598000552	dimerization interface [polypeptide binding]; other site
99598000553	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598000554	dimerization interface [polypeptide binding]; other site
99598000555	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598000556	dimerization interface [polypeptide binding]; other site
99598000557	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598000558	dimerization interface [polypeptide binding]; other site
99598000559	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
99598000560	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598000561	dimerization interface [polypeptide binding]; other site
99598000562	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598000563	dimerization interface [polypeptide binding]; other site
99598000564	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598000565	dimerization interface [polypeptide binding]; other site
99598000566	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598000567	dimerization interface [polypeptide binding]; other site
99598000568	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598000569	GAF domain; Region: GAF; pfam01590
99598000570	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598000571	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
99598000572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598000573	ATP binding site [chemical binding]; other site
99598000574	Mg2+ binding site [ion binding]; other site
99598000575	G-X-G motif; other site
99598000576	Response regulator receiver domain; Region: Response_reg; pfam00072
99598000577	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598000578	active site
99598000579	phosphorylation site [posttranslational modification]
99598000580	intermolecular recognition site; other site
99598000581	dimerization interface [polypeptide binding]; other site
99598000582	Response regulator receiver domain; Region: Response_reg; pfam00072
99598000583	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598000584	active site
99598000585	phosphorylation site [posttranslational modification]
99598000586	intermolecular recognition site; other site
99598000587	dimerization interface [polypeptide binding]; other site
99598000588	Response regulator receiver domain; Region: Response_reg; pfam00072
99598000589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598000590	active site
99598000591	phosphorylation site [posttranslational modification]
99598000592	intermolecular recognition site; other site
99598000593	dimerization interface [polypeptide binding]; other site
99598000594	Response regulator receiver domain; Region: Response_reg; pfam00072
99598000595	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598000596	active site
99598000597	phosphorylation site [posttranslational modification]
99598000598	intermolecular recognition site; other site
99598000599	dimerization interface [polypeptide binding]; other site
99598000600	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598000601	putative active site [active]
99598000602	heme pocket [chemical binding]; other site
99598000603	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598000604	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598000605	dimer interface [polypeptide binding]; other site
99598000606	phosphorylation site [posttranslational modification]
99598000607	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598000608	ATP binding site [chemical binding]; other site
99598000609	Mg2+ binding site [ion binding]; other site
99598000610	G-X-G motif; other site
99598000611	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598000612	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598000613	active site
99598000614	phosphorylation site [posttranslational modification]
99598000615	intermolecular recognition site; other site
99598000616	dimerization interface [polypeptide binding]; other site
99598000617	cytochrome c-550; Provisional; Region: psbV; PRK13618
99598000618	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
99598000619	photosystem II 47 kDa protein; Region: psbB; CHL00062
99598000620	Photosystem II protein; Region: PSII; cl08223
99598000621	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
99598000622	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
99598000623	pheophytin binding site; other site
99598000624	chlorophyll binding site; other site
99598000625	quinone binding site; other site
99598000626	Fe binding site [ion binding]; other site
99598000627	Phycobilisome protein; Region: Phycobilisome; cl08227
99598000628	Phycobilisome protein; Region: Phycobilisome; cl08227
99598000629	Phycobilisome protein; Region: Phycobilisome; cl08227
99598000630	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
99598000631	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
99598000632	Phycobilisome protein; Region: Phycobilisome; cl08227
99598000633	Phycobilisome protein; Region: Phycobilisome; cl08227
99598000634	Phycobilisome protein; Region: Phycobilisome; cl08227
99598000635	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
99598000636	protein I interface; other site
99598000637	D2 interface; other site
99598000638	protein T interface; other site
99598000639	chlorophyll binding site; other site
99598000640	beta carotene binding site; other site
99598000641	pheophytin binding site; other site
99598000642	manganese-stabilizing polypeptide interface; other site
99598000643	CP43 interface; other site
99598000644	protein L interface; other site
99598000645	oxygen evolving complex binding site; other site
99598000646	bromide binding site; other site
99598000647	quinone binding site; other site
99598000648	Fe binding site [ion binding]; other site
99598000649	core light harvesting interface; other site
99598000650	cytochrome b559 alpha subunit interface; other site
99598000651	cytochrome c-550 interface; other site
99598000652	protein J interface; other site
99598000653	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
99598000654	pheophytin binding site; other site
99598000655	chlorophyll binding site; other site
99598000656	quinone binding site; other site
99598000657	Fe binding site [ion binding]; other site
99598000658	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99598000659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598000660	active site
99598000661	phosphorylation site [posttranslational modification]
99598000662	intermolecular recognition site; other site
99598000663	dimerization interface [polypeptide binding]; other site
99598000664	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99598000665	DNA binding site [nucleotide binding]
99598000666	Hpt domain; Region: Hpt; pfam01627
99598000667	putative binding surface; other site
99598000668	active site
99598000669	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598000670	GAF domain; Region: GAF; pfam01590
99598000671	GAF domain; Region: GAF; cl17456
99598000672	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
99598000673	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598000674	putative active site [active]
99598000675	heme pocket [chemical binding]; other site
99598000676	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598000677	dimer interface [polypeptide binding]; other site
99598000678	phosphorylation site [posttranslational modification]
99598000679	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598000680	ATP binding site [chemical binding]; other site
99598000681	Mg2+ binding site [ion binding]; other site
99598000682	G-X-G motif; other site
99598000683	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598000684	active site
99598000685	phosphorylation site [posttranslational modification]
99598000686	intermolecular recognition site; other site
99598000687	dimerization interface [polypeptide binding]; other site
99598000688	photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056
99598000689	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
99598000690	photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704
99598000691	photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877
99598000692	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
99598000693	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
99598000694	active site
99598000695	metal binding site [ion binding]; metal-binding site
99598000696	Methyltransferase domain; Region: Methyltransf_23; pfam13489
99598000697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598000698	S-adenosylmethionine binding site [chemical binding]; other site
99598000699	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
99598000700	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
99598000701	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99598000702	Ligand Binding Site [chemical binding]; other site
99598000703	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99598000704	Ligand Binding Site [chemical binding]; other site
99598000705	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
99598000706	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
99598000707	putative NAD(P) binding site [chemical binding]; other site
99598000708	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
99598000709	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
99598000710	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
99598000711	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
99598000712	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598000713	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598000714	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598000715	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
99598000716	putative ADP-binding pocket [chemical binding]; other site
99598000717	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
99598000718	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
99598000719	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
99598000720	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
99598000721	putative valine binding site [chemical binding]; other site
99598000722	dimer interface [polypeptide binding]; other site
99598000723	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
99598000724	BON domain; Region: BON; cl02771
99598000725	hydrolase, alpha/beta fold family protein; Region: PLN02824
99598000726	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
99598000727	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
99598000728	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
99598000729	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
99598000730	TLC ATP/ADP transporter; Region: TLC; cl03940
99598000731	HEAT repeats; Region: HEAT_2; pfam13646
99598000732	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
99598000733	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
99598000734	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
99598000735	active site
99598000736	metal binding site [ion binding]; metal-binding site
99598000737	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
99598000738	FIST N domain; Region: FIST; pfam08495
99598000739	FIST C domain; Region: FIST_C; pfam10442
99598000740	CP12 domain; Region: CP12; pfam02672
99598000741	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
99598000742	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598000743	putative active site [active]
99598000744	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
99598000745	GMP synthase; Reviewed; Region: guaA; PRK00074
99598000746	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
99598000747	AMP/PPi binding site [chemical binding]; other site
99598000748	candidate oxyanion hole; other site
99598000749	catalytic triad [active]
99598000750	potential glutamine specificity residues [chemical binding]; other site
99598000751	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
99598000752	ATP Binding subdomain [chemical binding]; other site
99598000753	Ligand Binding sites [chemical binding]; other site
99598000754	Dimerization subdomain; other site
99598000755	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598000756	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598000757	active site
99598000758	phosphorylation site [posttranslational modification]
99598000759	intermolecular recognition site; other site
99598000760	dimerization interface [polypeptide binding]; other site
99598000761	PAS domain S-box; Region: sensory_box; TIGR00229
99598000762	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598000763	PAS fold; Region: PAS_3; pfam08447
99598000764	putative active site [active]
99598000765	heme pocket [chemical binding]; other site
99598000766	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
99598000767	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598000768	putative active site [active]
99598000769	heme pocket [chemical binding]; other site
99598000770	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598000771	dimer interface [polypeptide binding]; other site
99598000772	phosphorylation site [posttranslational modification]
99598000773	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598000774	ATP binding site [chemical binding]; other site
99598000775	Mg2+ binding site [ion binding]; other site
99598000776	G-X-G motif; other site
99598000777	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598000778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598000779	active site
99598000780	phosphorylation site [posttranslational modification]
99598000781	intermolecular recognition site; other site
99598000782	dimerization interface [polypeptide binding]; other site
99598000783	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
99598000784	GAF domain; Region: GAF; pfam01590
99598000785	Phytochrome region; Region: PHY; pfam00360
99598000786	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598000787	dimer interface [polypeptide binding]; other site
99598000788	phosphorylation site [posttranslational modification]
99598000789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598000790	ATP binding site [chemical binding]; other site
99598000791	Mg2+ binding site [ion binding]; other site
99598000792	G-X-G motif; other site
99598000793	Response regulator receiver domain; Region: Response_reg; pfam00072
99598000794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598000795	active site
99598000796	phosphorylation site [posttranslational modification]
99598000797	intermolecular recognition site; other site
99598000798	dimerization interface [polypeptide binding]; other site
99598000799	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
99598000800	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
99598000801	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
99598000802	Uncharacterized conserved protein [Function unknown]; Region: COG2128
99598000803	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
99598000804	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
99598000805	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
99598000806	Active site cavity [active]
99598000807	catalytic acid [active]
99598000808	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
99598000809	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
99598000810	active site
99598000811	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
99598000812	NB-ARC domain; Region: NB-ARC; pfam00931
99598000813	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
99598000814	PKC phosphorylation site [posttranslational modification]; other site
99598000815	ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020
99598000816	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
99598000817	putative multimerization interface [polypeptide binding]; other site
99598000818	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598000819	putative active site [active]
99598000820	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
99598000821	DDE superfamily endonuclease; Region: DDE_4; pfam13359
99598000822	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598000823	putative active site [active]
99598000824	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
99598000825	active site
99598000826	catalytic triad [active]
99598000827	oxyanion hole [active]
99598000828	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
99598000829	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
99598000830	multimerization interface [polypeptide binding]; other site
99598000831	RbcX protein; Region: RcbX; pfam02341
99598000832	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
99598000833	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
99598000834	homodimer interface [polypeptide binding]; other site
99598000835	active site
99598000836	heterodimer interface [polypeptide binding]; other site
99598000837	catalytic residue [active]
99598000838	metal binding site [ion binding]; metal-binding site
99598000839	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
99598000840	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
99598000841	oligomerization interface [polypeptide binding]; other site
99598000842	active site
99598000843	metal binding site [ion binding]; metal-binding site
99598000844	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598000845	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598000846	active site
99598000847	ATP binding site [chemical binding]; other site
99598000848	substrate binding site [chemical binding]; other site
99598000849	activation loop (A-loop); other site
99598000850	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598000851	structural tetrad; other site
99598000852	PQQ-like domain; Region: PQQ_2; pfam13360
99598000853	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
99598000854	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
99598000855	nucleotide binding site/active site [active]
99598000856	HIT family signature motif; other site
99598000857	catalytic residue [active]
99598000858	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
99598000859	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
99598000860	Nucleoside recognition; Region: Gate; pfam07670
99598000861	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
99598000862	S-layer homology domain; Region: SLH; pfam00395
99598000863	S-layer homology domain; Region: SLH; pfam00395
99598000864	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
99598000865	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
99598000866	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
99598000867	Active Sites [active]
99598000868	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
99598000869	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
99598000870	AAA domain; Region: AAA_11; pfam13086
99598000871	Part of AAA domain; Region: AAA_19; pfam13245
99598000872	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
99598000873	AAA domain; Region: AAA_30; pfam13604
99598000874	AAA domain; Region: AAA_12; pfam13087
99598000875	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
99598000876	putative active site [active]
99598000877	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
99598000878	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
99598000879	active site
99598000880	metal binding site [ion binding]; metal-binding site
99598000881	DNA binding site [nucleotide binding]
99598000882	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
99598000883	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
99598000884	PBP superfamily domain; Region: PBP_like_2; cl17296
99598000885	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
99598000886	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598000887	dimer interface [polypeptide binding]; other site
99598000888	conserved gate region; other site
99598000889	putative PBP binding loops; other site
99598000890	ABC-ATPase subunit interface; other site
99598000891	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
99598000892	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598000893	dimer interface [polypeptide binding]; other site
99598000894	conserved gate region; other site
99598000895	putative PBP binding loops; other site
99598000896	ABC-ATPase subunit interface; other site
99598000897	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14265
99598000898	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
99598000899	Walker A/P-loop; other site
99598000900	ATP binding site [chemical binding]; other site
99598000901	Q-loop/lid; other site
99598000902	ABC transporter signature motif; other site
99598000903	Walker B; other site
99598000904	D-loop; other site
99598000905	H-loop/switch region; other site
99598000906	Protein of unknown function (DUF433); Region: DUF433; pfam04255
99598000907	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
99598000908	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
99598000909	DHH family; Region: DHH; pfam01368
99598000910	Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139
99598000911	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
99598000912	Predicted membrane protein [Function unknown]; Region: COG2119
99598000913	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
99598000914	Predicted membrane protein [Function unknown]; Region: COG2119
99598000915	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
99598000916	putative acyl transferase; Provisional; Region: PRK10502
99598000917	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
99598000918	putative trimer interface [polypeptide binding]; other site
99598000919	putative active site [active]
99598000920	putative substrate binding site [chemical binding]; other site
99598000921	putative CoA binding site [chemical binding]; other site
99598000922	Uncharacterized conserved protein [Function unknown]; Region: COG1434
99598000923	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
99598000924	putative active site [active]
99598000925	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598000926	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
99598000927	putative ADP-binding pocket [chemical binding]; other site
99598000928	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
99598000929	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598000930	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598000931	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598000932	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598000933	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598000934	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
99598000935	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
99598000936	Probable Catalytic site; other site
99598000937	metal-binding site
99598000938	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
99598000939	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
99598000940	Probable Catalytic site; other site
99598000941	metal-binding site
99598000942	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
99598000943	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598000944	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598000945	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598000946	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598000947	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598000948	active site
99598000949	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
99598000950	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598000951	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598000952	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598000953	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598000954	active site
99598000955	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598000956	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598000957	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598000958	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598000959	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
99598000960	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
99598000961	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
99598000962	NAD binding site [chemical binding]; other site
99598000963	homotetramer interface [polypeptide binding]; other site
99598000964	homodimer interface [polypeptide binding]; other site
99598000965	active site
99598000966	substrate binding site [chemical binding]; other site
99598000967	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
99598000968	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598000969	active site
99598000970	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598000971	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598000972	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598000973	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598000974	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
99598000975	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
99598000976	Walker A/P-loop; other site
99598000977	ATP binding site [chemical binding]; other site
99598000978	Q-loop/lid; other site
99598000979	ABC transporter signature motif; other site
99598000980	Walker B; other site
99598000981	D-loop; other site
99598000982	H-loop/switch region; other site
99598000983	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
99598000984	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
99598000985	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
99598000986	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
99598000987	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
99598000988	NADP-binding site; other site
99598000989	homotetramer interface [polypeptide binding]; other site
99598000990	substrate binding site [chemical binding]; other site
99598000991	homodimer interface [polypeptide binding]; other site
99598000992	active site
99598000993	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598000994	putative active site [active]
99598000995	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598000996	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
99598000997	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
99598000998	Chain length determinant protein; Region: Wzz; pfam02706
99598000999	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
99598001000	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
99598001001	Magnesium ion binding site [ion binding]; other site
99598001002	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598001003	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598001004	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598001005	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598001006	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
99598001007	cyclase homology domain; Region: CHD; cd07302
99598001008	nucleotidyl binding site; other site
99598001009	metal binding site [ion binding]; metal-binding site
99598001010	dimer interface [polypeptide binding]; other site
99598001011	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
99598001012	iron-sulfur cluster [ion binding]; other site
99598001013	[2Fe-2S] cluster binding site [ion binding]; other site
99598001014	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
99598001015	Bacterial Ig-like domain; Region: Big_5; pfam13205
99598001016	MG2 domain; Region: A2M_N; pfam01835
99598001017	Alpha-2-macroglobulin family; Region: A2M; pfam00207
99598001018	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
99598001019	surface patch; other site
99598001020	specificity defining residues; other site
99598001021	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
99598001022	Transglycosylase; Region: Transgly; pfam00912
99598001023	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
99598001024	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
99598001025	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598001026	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598001027	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598001028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598001029	ATP binding site [chemical binding]; other site
99598001030	Mg2+ binding site [ion binding]; other site
99598001031	G-X-G motif; other site
99598001032	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
99598001033	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99598001034	metal binding site [ion binding]; metal-binding site
99598001035	active site
99598001036	I-site; other site
99598001037	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598001038	putative active site [active]
99598001039	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
99598001040	intersubunit interface [polypeptide binding]; other site
99598001041	active site
99598001042	zinc binding site [ion binding]; other site
99598001043	Na+ binding site [ion binding]; other site
99598001044	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598001045	GAF domain; Region: GAF; pfam01590
99598001046	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598001047	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598001048	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598001049	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598001050	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598001051	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598001052	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598001053	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598001054	dimer interface [polypeptide binding]; other site
99598001055	phosphorylation site [posttranslational modification]
99598001056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598001057	ATP binding site [chemical binding]; other site
99598001058	Mg2+ binding site [ion binding]; other site
99598001059	G-X-G motif; other site
99598001060	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
99598001061	carotene isomerase; Region: carot_isom; TIGR02730
99598001062	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
99598001063	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
99598001064	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
99598001065	Walker A/P-loop; other site
99598001066	ATP binding site [chemical binding]; other site
99598001067	Q-loop/lid; other site
99598001068	ABC transporter signature motif; other site
99598001069	Walker B; other site
99598001070	D-loop; other site
99598001071	H-loop/switch region; other site
99598001072	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
99598001073	mce related protein; Region: MCE; pfam02470
99598001074	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
99598001075	Clp protease ATP binding subunit; Region: clpC; CHL00095
99598001076	Clp amino terminal domain; Region: Clp_N; pfam02861
99598001077	Clp amino terminal domain; Region: Clp_N; pfam02861
99598001078	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598001079	Walker A motif; other site
99598001080	ATP binding site [chemical binding]; other site
99598001081	Walker B motif; other site
99598001082	arginine finger; other site
99598001083	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598001084	Walker A motif; other site
99598001085	ATP binding site [chemical binding]; other site
99598001086	Walker B motif; other site
99598001087	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
99598001088	geranylgeranyl reductase; Region: ChlP; TIGR02028
99598001089	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
99598001090	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
99598001091	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598001092	S-adenosylmethionine binding site [chemical binding]; other site
99598001093	methionine sulfoxide reductase A; Provisional; Region: PRK00058
99598001094	proton extrusion protein PcxA; Provisional; Region: PRK02507
99598001095	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
99598001096	MltA specific insert domain; Region: MltA; pfam03562
99598001097	3D domain; Region: 3D; pfam06725
99598001098	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
99598001099	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598001100	non-specific DNA binding site [nucleotide binding]; other site
99598001101	salt bridge; other site
99598001102	sequence-specific DNA binding site [nucleotide binding]; other site
99598001103	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
99598001104	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
99598001105	NodB motif; other site
99598001106	active site
99598001107	catalytic site [active]
99598001108	metal binding site [ion binding]; metal-binding site
99598001109	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99598001110	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99598001111	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
99598001112	Peptidase family M23; Region: Peptidase_M23; pfam01551
99598001113	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598001114	DevC protein; Region: devC; TIGR01185
99598001115	FtsX-like permease family; Region: FtsX; pfam02687
99598001116	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
99598001117	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
99598001118	Walker A/P-loop; other site
99598001119	ATP binding site [chemical binding]; other site
99598001120	Q-loop/lid; other site
99598001121	ABC transporter signature motif; other site
99598001122	Walker B; other site
99598001123	D-loop; other site
99598001124	H-loop/switch region; other site
99598001125	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598001126	GAF domain; Region: GAF; pfam01590
99598001127	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278
99598001128	PAS domain; Region: PAS_9; pfam13426
99598001129	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598001130	putative active site [active]
99598001131	heme pocket [chemical binding]; other site
99598001132	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598001133	GAF domain; Region: GAF_2; pfam13185
99598001134	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598001135	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598001136	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598001137	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598001138	dimer interface [polypeptide binding]; other site
99598001139	phosphorylation site [posttranslational modification]
99598001140	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598001141	ATP binding site [chemical binding]; other site
99598001142	Mg2+ binding site [ion binding]; other site
99598001143	G-X-G motif; other site
99598001144	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598001145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598001146	active site
99598001147	phosphorylation site [posttranslational modification]
99598001148	intermolecular recognition site; other site
99598001149	dimerization interface [polypeptide binding]; other site
99598001150	Response regulator receiver domain; Region: Response_reg; pfam00072
99598001151	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598001152	active site
99598001153	phosphorylation site [posttranslational modification]
99598001154	intermolecular recognition site; other site
99598001155	dimerization interface [polypeptide binding]; other site
99598001156	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
99598001157	putative binding surface; other site
99598001158	active site
99598001159	Ferredoxin [Energy production and conversion]; Region: COG1146
99598001160	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
99598001161	EF-hand domain pair; Region: EF_hand_5; pfam13499
99598001162	Ca2+ binding site [ion binding]; other site
99598001163	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
99598001164	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598001165	S-adenosylmethionine binding site [chemical binding]; other site
99598001166	recombination protein RecR; Reviewed; Region: recR; PRK00076
99598001167	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
99598001168	RecR protein; Region: RecR; pfam02132
99598001169	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
99598001170	putative active site [active]
99598001171	putative metal-binding site [ion binding]; other site
99598001172	tetramer interface [polypeptide binding]; other site
99598001173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
99598001174	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598001175	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598001176	binding surface
99598001177	TPR motif; other site
99598001178	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
99598001179	protein I interface; other site
99598001180	D2 interface; other site
99598001181	protein T interface; other site
99598001182	chlorophyll binding site; other site
99598001183	beta carotene binding site; other site
99598001184	pheophytin binding site; other site
99598001185	manganese-stabilizing polypeptide interface; other site
99598001186	CP43 interface; other site
99598001187	protein L interface; other site
99598001188	oxygen evolving complex binding site; other site
99598001189	bromide binding site; other site
99598001190	quinone binding site; other site
99598001191	Fe binding site [ion binding]; other site
99598001192	core light harvesting interface; other site
99598001193	cytochrome b559 alpha subunit interface; other site
99598001194	cytochrome c-550 interface; other site
99598001195	protein J interface; other site
99598001196	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598001197	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598001198	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
99598001199	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598001200	FeS/SAM binding site; other site
99598001201	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
99598001202	Methyltransferase domain; Region: Methyltransf_31; pfam13847
99598001203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598001204	S-adenosylmethionine binding site [chemical binding]; other site
99598001205	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99598001206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598001207	active site
99598001208	phosphorylation site [posttranslational modification]
99598001209	intermolecular recognition site; other site
99598001210	dimerization interface [polypeptide binding]; other site
99598001211	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99598001212	DNA binding site [nucleotide binding]
99598001213	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
99598001214	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598001215	S-adenosylmethionine binding site [chemical binding]; other site
99598001216	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598001217	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
99598001218	Coenzyme A binding pocket [chemical binding]; other site
99598001219	CHASE3 domain; Region: CHASE3; pfam05227
99598001220	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
99598001221	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598001222	putative active site [active]
99598001223	heme pocket [chemical binding]; other site
99598001224	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598001225	dimer interface [polypeptide binding]; other site
99598001226	phosphorylation site [posttranslational modification]
99598001227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598001228	ATP binding site [chemical binding]; other site
99598001229	Mg2+ binding site [ion binding]; other site
99598001230	G-X-G motif; other site
99598001231	Response regulator receiver domain; Region: Response_reg; pfam00072
99598001232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598001233	active site
99598001234	phosphorylation site [posttranslational modification]
99598001235	intermolecular recognition site; other site
99598001236	dimerization interface [polypeptide binding]; other site
99598001237	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598001238	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598001239	active site
99598001240	phosphorylation site [posttranslational modification]
99598001241	intermolecular recognition site; other site
99598001242	dimerization interface [polypeptide binding]; other site
99598001243	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598001244	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598001245	dimer interface [polypeptide binding]; other site
99598001246	phosphorylation site [posttranslational modification]
99598001247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598001248	ATP binding site [chemical binding]; other site
99598001249	Mg2+ binding site [ion binding]; other site
99598001250	G-X-G motif; other site
99598001251	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
99598001252	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
99598001253	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598001254	dimer interface [polypeptide binding]; other site
99598001255	phosphorylation site [posttranslational modification]
99598001256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598001257	ATP binding site [chemical binding]; other site
99598001258	Mg2+ binding site [ion binding]; other site
99598001259	G-X-G motif; other site
99598001260	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
99598001261	Electron transfer DM13; Region: DM13; pfam10517
99598001262	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
99598001263	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
99598001264	DXD motif; other site
99598001265	PilZ domain; Region: PilZ; pfam07238
99598001266	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
99598001267	active site
99598001268	ATP binding site [chemical binding]; other site
99598001269	Phosphotransferase enzyme family; Region: APH; pfam01636
99598001270	substrate binding site [chemical binding]; other site
99598001271	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598001272	putative active site [active]
99598001273	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
99598001274	active site
99598001275	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
99598001276	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
99598001277	acyl-activating enzyme (AAE) consensus motif; other site
99598001278	putative AMP binding site [chemical binding]; other site
99598001279	putative active site [active]
99598001280	putative CoA binding site [chemical binding]; other site
99598001281	O-succinylbenzoate synthase; Provisional; Region: PRK02714
99598001282	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
99598001283	active site
99598001284	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
99598001285	UbiA prenyltransferase family; Region: UbiA; pfam01040
99598001286	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
99598001287	chorismate binding enzyme; Region: Chorismate_bind; cl10555
99598001288	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
99598001289	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
99598001290	putative catalytic cysteine [active]
99598001291	Peptidase family M48; Region: Peptidase_M48; cl12018
99598001292	T5orf172 domain; Region: T5orf172; pfam10544
99598001293	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
99598001294	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
99598001295	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
99598001296	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
99598001297	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598001298	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598001299	membrane-bound complex binding site; other site
99598001300	hinge residues; other site
99598001301	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
99598001302	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
99598001303	homodimer interface [polypeptide binding]; other site
99598001304	metal binding site [ion binding]; metal-binding site
99598001305	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
99598001306	homodimer interface [polypeptide binding]; other site
99598001307	active site
99598001308	putative chemical substrate binding site [chemical binding]; other site
99598001309	metal binding site [ion binding]; metal-binding site
99598001310	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
99598001311	Protein of unknown function (DUF456); Region: DUF456; cl01069
99598001312	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
99598001313	Ycf27; Reviewed; Region: orf27; CHL00148
99598001314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598001315	active site
99598001316	phosphorylation site [posttranslational modification]
99598001317	intermolecular recognition site; other site
99598001318	dimerization interface [polypeptide binding]; other site
99598001319	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99598001320	DNA binding site [nucleotide binding]
99598001321	DNA repair protein RadA; Provisional; Region: PRK11823
99598001322	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
99598001323	Walker A motif/ATP binding site; other site
99598001324	ATP binding site [chemical binding]; other site
99598001325	Walker B motif; other site
99598001326	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
99598001327	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
99598001328	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
99598001329	active site
99598001330	metal binding site [ion binding]; metal-binding site
99598001331	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598001332	Coenzyme A binding pocket [chemical binding]; other site
99598001333	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598001334	putative active site [active]
99598001335	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
99598001336	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99598001337	active site
99598001338	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
99598001339	cobalamin synthase; Reviewed; Region: cobS; PRK00235
99598001340	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
99598001341	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
99598001342	Photosystem II 4 kDa reaction centre component; Region: PsbK; pfam02533
99598001343	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
99598001344	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99598001345	catalytic loop [active]
99598001346	iron binding site [ion binding]; other site
99598001347	photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989
99598001348	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99598001349	Ligand Binding Site [chemical binding]; other site
99598001350	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99598001351	Ligand Binding Site [chemical binding]; other site
99598001352	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
99598001353	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
99598001354	DNA binding residues [nucleotide binding]
99598001355	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
99598001356	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
99598001357	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
99598001358	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
99598001359	phosphopeptide binding site; other site
99598001360	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598001361	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598001362	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598001363	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
99598001364	BNR repeat-like domain; Region: BNR_2; pfam13088
99598001365	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
99598001366	Phycobilisome protein; Region: Phycobilisome; cl08227
99598001367	Phycobilisome protein; Region: Phycobilisome; cl08227
99598001368	phycobillisome linker protein; Region: apcE; CHL00091
99598001369	Phycobilisome protein; Region: Phycobilisome; cl08227
99598001370	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
99598001371	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
99598001372	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
99598001373	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
99598001374	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
99598001375	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
99598001376	ATP binding site [chemical binding]; other site
99598001377	Protein phosphatase 2C; Region: PP2C_2; pfam13672
99598001378	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
99598001379	metal ion-dependent adhesion site (MIDAS); other site
99598001380	XisH protein; Region: XisH; pfam08814
99598001381	XisI protein; Region: XisI; pfam08869
99598001382	Methyltransferase domain; Region: Methyltransf_31; pfam13847
99598001383	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598001384	S-adenosylmethionine binding site [chemical binding]; other site
99598001385	ATP synthase I chain; Region: ATP_synt_I; pfam03899
99598001386	ATP synthase CF0 A subunit; Region: atpI; CHL00046
99598001387	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
99598001388	F0F1 ATP synthase subunit C; Validated; Region: PRK07354
99598001389	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
99598001390	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
99598001391	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
99598001392	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
99598001393	ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145
99598001394	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
99598001395	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
99598001396	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
99598001397	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
99598001398	beta subunit interaction interface [polypeptide binding]; other site
99598001399	Walker A motif; other site
99598001400	ATP binding site [chemical binding]; other site
99598001401	Walker B motif; other site
99598001402	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
99598001403	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
99598001404	core domain interface [polypeptide binding]; other site
99598001405	delta subunit interface [polypeptide binding]; other site
99598001406	epsilon subunit interface [polypeptide binding]; other site
99598001407	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
99598001408	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598001409	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
99598001410	Coenzyme A binding pocket [chemical binding]; other site
99598001411	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598001412	putative active site [active]
99598001413	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
99598001414	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
99598001415	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
99598001416	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
99598001417	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
99598001418	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
99598001419	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
99598001420	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
99598001421	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
99598001422	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
99598001423	active site
99598001424	PHP Thumb interface [polypeptide binding]; other site
99598001425	metal binding site [ion binding]; metal-binding site
99598001426	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
99598001427	protein-splicing catalytic site; other site
99598001428	thioester formation/cholesterol transfer; other site
99598001429	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
99598001430	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
99598001431	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
99598001432	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
99598001433	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
99598001434	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
99598001435	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
99598001436	Pantoate-beta-alanine ligase; Region: PanC; cd00560
99598001437	active site
99598001438	ATP-binding site [chemical binding]; other site
99598001439	pantoate-binding site; other site
99598001440	HXXH motif; other site
99598001441	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
99598001442	CMP-binding site; other site
99598001443	The sites determining sugar specificity; other site
99598001444	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
99598001445	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
99598001446	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
99598001447	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
99598001448	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
99598001449	dimerization interface [polypeptide binding]; other site
99598001450	putative ATP binding site [chemical binding]; other site
99598001451	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
99598001452	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
99598001453	active site
99598001454	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
99598001455	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
99598001456	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
99598001457	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
99598001458	MltA specific insert domain; Region: MltA; pfam03562
99598001459	3D domain; Region: 3D; pfam06725
99598001460	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
99598001461	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
99598001462	Surface antigen; Region: Bac_surface_Ag; pfam01103
99598001463	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598001464	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598001465	active site
99598001466	ATP binding site [chemical binding]; other site
99598001467	substrate binding site [chemical binding]; other site
99598001468	activation loop (A-loop); other site
99598001469	Uncharacterized conserved protein [Function unknown]; Region: COG1262
99598001470	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
99598001471	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
99598001472	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598001473	dimer interface [polypeptide binding]; other site
99598001474	conserved gate region; other site
99598001475	putative PBP binding loops; other site
99598001476	ABC-ATPase subunit interface; other site
99598001477	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598001478	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
99598001479	putative ADP-binding pocket [chemical binding]; other site
99598001480	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
99598001481	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
99598001482	homodimer interface [polypeptide binding]; other site
99598001483	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598001484	catalytic residue [active]
99598001485	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
99598001486	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
99598001487	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99598001488	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598001489	active site
99598001490	phosphorylation site [posttranslational modification]
99598001491	intermolecular recognition site; other site
99598001492	dimerization interface [polypeptide binding]; other site
99598001493	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99598001494	DNA binding site [nucleotide binding]
99598001495	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
99598001496	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99598001497	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598001498	homodimer interface [polypeptide binding]; other site
99598001499	catalytic residue [active]
99598001500	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
99598001501	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598001502	S-adenosylmethionine binding site [chemical binding]; other site
99598001503	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
99598001504	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
99598001505	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
99598001506	SnoaL-like domain; Region: SnoaL_3; pfam13474
99598001507	hypothetical protein; Provisional; Region: PRK10621
99598001508	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
99598001509	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
99598001510	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598001511	motif II; other site
99598001512	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
99598001513	EamA-like transporter family; Region: EamA; pfam00892
99598001514	EamA-like transporter family; Region: EamA; pfam00892
99598001515	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598001516	putative active site [active]
99598001517	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
99598001518	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
99598001519	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
99598001520	N-terminal domain interface [polypeptide binding]; other site
99598001521	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
99598001522	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
99598001523	substrate binding pocket [chemical binding]; other site
99598001524	active site
99598001525	iron coordination sites [ion binding]; other site
99598001526	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
99598001527	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
99598001528	putative NAD(P) binding site [chemical binding]; other site
99598001529	putative active site [active]
99598001530	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270
99598001531	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
99598001532	putative NAD(P) binding site [chemical binding]; other site
99598001533	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
99598001534	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
99598001535	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
99598001536	active site
99598001537	Methyltransferase domain; Region: Methyltransf_23; pfam13489
99598001538	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598001539	S-adenosylmethionine binding site [chemical binding]; other site
99598001540	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598001541	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598001542	active site
99598001543	ATP binding site [chemical binding]; other site
99598001544	substrate binding site [chemical binding]; other site
99598001545	activation loop (A-loop); other site
99598001546	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
99598001547	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598001548	motif II; other site
99598001549	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
99598001550	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
99598001551	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99598001552	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
99598001553	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
99598001554	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
99598001555	putative active site [active]
99598001556	catalytic site [active]
99598001557	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
99598001558	putative active site [active]
99598001559	catalytic site [active]
99598001560	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
99598001561	Helix-hairpin-helix motif; Region: HHH; pfam00633
99598001562	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
99598001563	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
99598001564	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99598001565	catalytic residue [active]
99598001566	chromosome segregation protein; Provisional; Region: PRK02224
99598001567	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
99598001568	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598001569	S-adenosylmethionine binding site [chemical binding]; other site
99598001570	S-layer homology domain; Region: SLH; pfam00395
99598001571	S-layer homology domain; Region: SLH; pfam00395
99598001572	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
99598001573	Fasciclin domain; Region: Fasciclin; pfam02469
99598001574	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598001575	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598001576	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598001577	secreted effector protein PipB; Provisional; Region: PRK15197
99598001578	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
99598001579	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598001580	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598001581	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598001582	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598001583	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
99598001584	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
99598001585	active site
99598001586	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
99598001587	Response regulator receiver domain; Region: Response_reg; pfam00072
99598001588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598001589	active site
99598001590	phosphorylation site [posttranslational modification]
99598001591	intermolecular recognition site; other site
99598001592	dimerization interface [polypeptide binding]; other site
99598001593	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598001594	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598001595	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598001596	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598001597	dimer interface [polypeptide binding]; other site
99598001598	phosphorylation site [posttranslational modification]
99598001599	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598001600	ATP binding site [chemical binding]; other site
99598001601	Mg2+ binding site [ion binding]; other site
99598001602	G-X-G motif; other site
99598001603	Response regulator receiver domain; Region: Response_reg; pfam00072
99598001604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598001605	active site
99598001606	phosphorylation site [posttranslational modification]
99598001607	intermolecular recognition site; other site
99598001608	dimerization interface [polypeptide binding]; other site
99598001609	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
99598001610	GAF domain; Region: GAF; pfam01590
99598001611	Phytochrome region; Region: PHY; pfam00360
99598001612	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598001613	dimer interface [polypeptide binding]; other site
99598001614	phosphorylation site [posttranslational modification]
99598001615	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598001616	ATP binding site [chemical binding]; other site
99598001617	Mg2+ binding site [ion binding]; other site
99598001618	G-X-G motif; other site
99598001619	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
99598001620	putative active site [active]
99598001621	homotetrameric interface [polypeptide binding]; other site
99598001622	metal binding site [ion binding]; metal-binding site
99598001623	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
99598001624	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
99598001625	active site
99598001626	metal binding site [ion binding]; metal-binding site
99598001627	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
99598001628	DNA primase; Validated; Region: dnaG; PRK05667
99598001629	CHC2 zinc finger; Region: zf-CHC2; pfam01807
99598001630	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
99598001631	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
99598001632	active site
99598001633	metal binding site [ion binding]; metal-binding site
99598001634	interdomain interaction site; other site
99598001635	Uncharacterized conserved protein [Function unknown]; Region: COG5464
99598001636	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
99598001637	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598001638	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598001639	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598001640	hypothetical protein; Reviewed; Region: PRK12497
99598001641	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
99598001642	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
99598001643	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598001644	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598001645	binding surface
99598001646	TPR motif; other site
99598001647	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598001648	binding surface
99598001649	TPR motif; other site
99598001650	TPR repeat; Region: TPR_11; pfam13414
99598001651	TPR repeat; Region: TPR_11; pfam13414
99598001652	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598001653	binding surface
99598001654	TPR motif; other site
99598001655	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598001656	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598001657	Tetratricopeptide repeat; Region: TPR_17; pfam13431
99598001658	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
99598001659	TrkA-N domain; Region: TrkA_N; pfam02254
99598001660	TrkA-C domain; Region: TrkA_C; pfam02080
99598001661	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
99598001662	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
99598001663	tocopherol O-methyltransferase; Region: PLN02244
99598001664	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598001665	S-adenosylmethionine binding site [chemical binding]; other site
99598001666	Protein of unknown function (DUF419); Region: DUF419; cl15265
99598001667	tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887
99598001668	UbiA prenyltransferase family; Region: UbiA; pfam01040
99598001669	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598001670	binding surface
99598001671	TPR repeat; Region: TPR_11; pfam13414
99598001672	TPR motif; other site
99598001673	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562
99598001674	short chain dehydrogenase; Provisional; Region: PRK06701
99598001675	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
99598001676	NAD binding site [chemical binding]; other site
99598001677	metal binding site [ion binding]; metal-binding site
99598001678	active site
99598001679	Domain of unknown function DUF11; Region: DUF11; pfam01345
99598001680	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
99598001681	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
99598001682	cofactor binding site; other site
99598001683	DNA binding site [nucleotide binding]
99598001684	substrate interaction site [chemical binding]; other site
99598001685	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
99598001686	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
99598001687	active site
99598001688	homodimer interface [polypeptide binding]; other site
99598001689	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
99598001690	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
99598001691	putative NAD(P) binding site [chemical binding]; other site
99598001692	homodimer interface [polypeptide binding]; other site
99598001693	homotetramer interface [polypeptide binding]; other site
99598001694	active site
99598001695	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
99598001696	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
99598001697	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
99598001698	active site
99598001699	metal binding site [ion binding]; metal-binding site
99598001700	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
99598001701	active site
99598001702	dinuclear metal binding site [ion binding]; other site
99598001703	dimerization interface [polypeptide binding]; other site
99598001704	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
99598001705	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
99598001706	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598001707	N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510
99598001708	amidase catalytic site [active]
99598001709	Zn binding residues [ion binding]; other site
99598001710	substrate binding site [chemical binding]; other site
99598001711	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
99598001712	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598001713	binding surface
99598001714	TPR motif; other site
99598001715	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
99598001716	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598001717	binding surface
99598001718	TPR motif; other site
99598001719	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598001720	binding surface
99598001721	TPR motif; other site
99598001722	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598001723	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598001724	binding surface
99598001725	TPR motif; other site
99598001726	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598001727	binding surface
99598001728	TPR motif; other site
99598001729	CHAT domain; Region: CHAT; pfam12770
99598001730	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
99598001731	RNA/DNA hybrid binding site [nucleotide binding]; other site
99598001732	active site
99598001733	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
99598001734	active site
99598001735	Predicted membrane protein [Function unknown]; Region: COG2324
99598001736	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
99598001737	ribosomal protein L21; Region: rpl21; CHL00075
99598001738	Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541
99598001739	Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417
99598001740	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
99598001741	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598001742	Walker A motif; other site
99598001743	ATP binding site [chemical binding]; other site
99598001744	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
99598001745	protein I interface; other site
99598001746	D2 interface; other site
99598001747	protein T interface; other site
99598001748	chlorophyll binding site; other site
99598001749	beta carotene binding site; other site
99598001750	pheophytin binding site; other site
99598001751	manganese-stabilizing polypeptide interface; other site
99598001752	CP43 interface; other site
99598001753	protein L interface; other site
99598001754	oxygen evolving complex binding site; other site
99598001755	bromide binding site; other site
99598001756	quinone binding site; other site
99598001757	Fe binding site [ion binding]; other site
99598001758	core light harvesting interface; other site
99598001759	cytochrome b559 alpha subunit interface; other site
99598001760	cytochrome c-550 interface; other site
99598001761	protein J interface; other site
99598001762	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
99598001763	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
99598001764	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
99598001765	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
99598001766	putative active site [active]
99598001767	catalytic site [active]
99598001768	putative metal binding site [ion binding]; other site
99598001769	Methyltransferase domain; Region: Methyltransf_23; pfam13489
99598001770	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598001771	S-adenosylmethionine binding site [chemical binding]; other site
99598001772	precorrin-3B synthase; Region: CobG; TIGR02435
99598001773	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
99598001774	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
99598001775	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
99598001776	Precorrin-8X methylmutase; Region: CbiC; pfam02570
99598001777	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
99598001778	active site
99598001779	SAM binding site [chemical binding]; other site
99598001780	homodimer interface [polypeptide binding]; other site
99598001781	Domain of unknown function DUF11; Region: DUF11; cl17728
99598001782	Domain of unknown function DUF11; Region: DUF11; cl17728
99598001783	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
99598001784	conserved repeat domain; Region: B_ant_repeat; TIGR01451
99598001785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
99598001786	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
99598001787	H+ Antiporter protein; Region: 2A0121; TIGR00900
99598001788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598001789	putative substrate translocation pore; other site
99598001790	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
99598001791	MarR family; Region: MarR; pfam01047
99598001792	ABC-2 type transporter; Region: ABC2_membrane; cl17235
99598001793	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
99598001794	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
99598001795	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598001796	Walker A/P-loop; other site
99598001797	ATP binding site [chemical binding]; other site
99598001798	Q-loop/lid; other site
99598001799	ABC transporter signature motif; other site
99598001800	Walker B; other site
99598001801	D-loop; other site
99598001802	H-loop/switch region; other site
99598001803	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
99598001804	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
99598001805	phosphopeptide binding site; other site
99598001806	PAS domain S-box; Region: sensory_box; TIGR00229
99598001807	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598001808	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598001809	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
99598001810	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99598001811	metal binding site [ion binding]; metal-binding site
99598001812	active site
99598001813	I-site; other site
99598001814	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99598001815	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
99598001816	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
99598001817	active site
99598001818	dimer interface [polypeptide binding]; other site
99598001819	non-prolyl cis peptide bond; other site
99598001820	insertion regions; other site
99598001821	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
99598001822	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
99598001823	active site
99598001824	non-prolyl cis peptide bond; other site
99598001825	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
99598001826	putative amidase; Provisional; Region: PRK06169
99598001827	Amidase; Region: Amidase; pfam01425
99598001828	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
99598001829	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
99598001830	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
99598001831	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
99598001832	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
99598001833	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
99598001834	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
99598001835	metal ion-dependent adhesion site (MIDAS); other site
99598001836	Protein of unknown function, DUF485; Region: DUF485; pfam04341
99598001837	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
99598001838	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
99598001839	Na binding site [ion binding]; other site
99598001840	Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909
99598001841	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
99598001842	active site
99598001843	Zn binding site [ion binding]; other site
99598001844	AAA ATPase domain; Region: AAA_16; pfam13191
99598001845	NACHT domain; Region: NACHT; pfam05729
99598001846	WD domain, G-beta repeat; Region: WD40; pfam00400
99598001847	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598001848	structural tetrad; other site
99598001849	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598001850	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598001851	structural tetrad; other site
99598001852	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598001853	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
99598001854	putative active site [active]
99598001855	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99598001856	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598001857	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
99598001858	Walker A/P-loop; other site
99598001859	ATP binding site [chemical binding]; other site
99598001860	Q-loop/lid; other site
99598001861	ABC transporter signature motif; other site
99598001862	Walker B; other site
99598001863	D-loop; other site
99598001864	H-loop/switch region; other site
99598001865	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
99598001866	putative dimer interface [polypeptide binding]; other site
99598001867	putative [2Fe-2S] cluster binding site [ion binding]; other site
99598001868	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
99598001869	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
99598001870	nucleotide binding site [chemical binding]; other site
99598001871	Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
99598001872	Predicted transcriptional regulators [Transcription]; Region: COG1695
99598001873	Transcriptional regulator PadR-like family; Region: PadR; cl17335
99598001874	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
99598001875	DNA methylase; Region: N6_N4_Mtase; cl17433
99598001876	Methyltransferase domain; Region: Methyltransf_26; pfam13659
99598001877	gamma-glutamyl kinase; Provisional; Region: PRK05429
99598001878	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
99598001879	nucleotide binding site [chemical binding]; other site
99598001880	homotetrameric interface [polypeptide binding]; other site
99598001881	putative phosphate binding site [ion binding]; other site
99598001882	putative allosteric binding site; other site
99598001883	PUA domain; Region: PUA; pfam01472
99598001884	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase
99598001885	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598001886	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
99598001887	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
99598001888	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
99598001889	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
99598001890	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598001891	Coenzyme A binding pocket [chemical binding]; other site
99598001892	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
99598001893	homodecamer interface [polypeptide binding]; other site
99598001894	GTP cyclohydrolase I; Provisional; Region: PLN03044
99598001895	active site
99598001896	putative catalytic site residues [active]
99598001897	zinc binding site [ion binding]; other site
99598001898	GTP-CH-I/GFRP interaction surface; other site
99598001899	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
99598001900	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
99598001901	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
99598001902	dimer interface [polypeptide binding]; other site
99598001903	RNA polymerase sigma factor; Provisional; Region: PRK12518
99598001904	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99598001905	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99598001906	DNA binding residues [nucleotide binding]
99598001907	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
99598001908	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
99598001909	tetramer interface [polypeptide binding]; other site
99598001910	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598001911	catalytic residue [active]
99598001912	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
99598001913	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598001914	Walker A motif; other site
99598001915	ATP binding site [chemical binding]; other site
99598001916	Walker B motif; other site
99598001917	arginine finger; other site
99598001918	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598001919	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598001920	active site
99598001921	phosphorylation site [posttranslational modification]
99598001922	intermolecular recognition site; other site
99598001923	dimerization interface [polypeptide binding]; other site
99598001924	Response regulator receiver domain; Region: Response_reg; pfam00072
99598001925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598001926	active site
99598001927	phosphorylation site [posttranslational modification]
99598001928	intermolecular recognition site; other site
99598001929	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598001930	dimerization interface [polypeptide binding]; other site
99598001931	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598001932	dimer interface [polypeptide binding]; other site
99598001933	phosphorylation site [posttranslational modification]
99598001934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598001935	ATP binding site [chemical binding]; other site
99598001936	Mg2+ binding site [ion binding]; other site
99598001937	G-X-G motif; other site
99598001938	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598001939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598001940	active site
99598001941	phosphorylation site [posttranslational modification]
99598001942	intermolecular recognition site; other site
99598001943	dimerization interface [polypeptide binding]; other site
99598001944	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598001945	dimer interface [polypeptide binding]; other site
99598001946	phosphorylation site [posttranslational modification]
99598001947	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598001948	ATP binding site [chemical binding]; other site
99598001949	Mg2+ binding site [ion binding]; other site
99598001950	G-X-G motif; other site
99598001951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
99598001952	conserved hypothetical protein; Region: TIGR03492
99598001953	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
99598001954	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
99598001955	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
99598001956	catalytic triad [active]
99598001957	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
99598001958	30S subunit binding site; other site
99598001959	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
99598001960	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
99598001961	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
99598001962	Walker A/P-loop; other site
99598001963	ATP binding site [chemical binding]; other site
99598001964	Q-loop/lid; other site
99598001965	ABC transporter signature motif; other site
99598001966	Walker B; other site
99598001967	D-loop; other site
99598001968	H-loop/switch region; other site
99598001969	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
99598001970	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598001971	substrate binding pocket [chemical binding]; other site
99598001972	membrane-bound complex binding site; other site
99598001973	hinge residues; other site
99598001974	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
99598001975	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598001976	dimer interface [polypeptide binding]; other site
99598001977	conserved gate region; other site
99598001978	putative PBP binding loops; other site
99598001979	ABC-ATPase subunit interface; other site
99598001980	XisI protein; Region: XisI; pfam08869
99598001981	Staphylococcal nuclease homologues; Region: SNc; smart00318
99598001982	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
99598001983	Catalytic site; other site
99598001984	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
99598001985	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
99598001986	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
99598001987	Helix-turn-helix domain; Region: HTH_25; pfam13413
99598001988	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
99598001989	nitrilase; Region: PLN02798
99598001990	putative active site [active]
99598001991	catalytic triad [active]
99598001992	dimer interface [polypeptide binding]; other site
99598001993	GTPase CgtA; Reviewed; Region: obgE; PRK12299
99598001994	GTP1/OBG; Region: GTP1_OBG; pfam01018
99598001995	Obg GTPase; Region: Obg; cd01898
99598001996	G1 box; other site
99598001997	GTP/Mg2+ binding site [chemical binding]; other site
99598001998	Switch I region; other site
99598001999	G2 box; other site
99598002000	G3 box; other site
99598002001	Switch II region; other site
99598002002	G4 box; other site
99598002003	G5 box; other site
99598002004	tellurium resistance terB-like protein; Region: terB_like; cd07177
99598002005	metal binding site [ion binding]; metal-binding site
99598002006	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
99598002007	Uncharacterized ACR (DUF711); Region: DUF711; pfam05167
99598002008	TIGR00701 family protein; Region: TIGR00701
99598002009	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
99598002010	Beta-lactamase; Region: Beta-lactamase; pfam00144
99598002011	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
99598002012	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
99598002013	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
99598002014	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
99598002015	Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636
99598002016	Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636
99598002017	conserved hypothetical protein; Region: TIGR02231
99598002018	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
99598002019	Modifier of rudimentary (Mod(r)) protein; Region: Mod_r; pfam07200
99598002020	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
99598002021	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99598002022	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99598002023	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
99598002024	putative dimerization interface [polypeptide binding]; other site
99598002025	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
99598002026	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
99598002027	Hexamer interface [polypeptide binding]; other site
99598002028	Hexagonal pore residue; other site
99598002029	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
99598002030	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
99598002031	Hexamer interface [polypeptide binding]; other site
99598002032	Hexagonal pore residue; other site
99598002033	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
99598002034	putative trimer interface [polypeptide binding]; other site
99598002035	putative CoA binding site [chemical binding]; other site
99598002036	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
99598002037	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
99598002038	trimer interface [polypeptide binding]; other site
99598002039	active site
99598002040	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
99598002041	putative multimerization interface [polypeptide binding]; other site
99598002042	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
99598002043	putative multimerization interface [polypeptide binding]; other site
99598002044	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
99598002045	putative multimerization interface [polypeptide binding]; other site
99598002046	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
99598002047	Hexamer/Pentamer interface [polypeptide binding]; other site
99598002048	central pore; other site
99598002049	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
99598002050	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
99598002051	Hexamer interface [polypeptide binding]; other site
99598002052	Hexagonal pore residue; other site
99598002053	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
99598002054	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
99598002055	Hexamer interface [polypeptide binding]; other site
99598002056	Hexagonal pore residue; other site
99598002057	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
99598002058	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
99598002059	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
99598002060	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
99598002061	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
99598002062	light-harvesting-like protein 3; Provisional; Region: PLN00014
99598002063	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
99598002064	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99598002065	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002066	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598002067	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002068	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002069	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
99598002070	ATP-grasp domain; Region: ATP-grasp; pfam02222
99598002071	TPR repeat; Region: TPR_11; pfam13414
99598002072	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598002073	binding surface
99598002074	TPR motif; other site
99598002075	TPR repeat; Region: TPR_11; pfam13414
99598002076	TPR repeat; Region: TPR_11; pfam13414
99598002077	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598002078	binding surface
99598002079	TPR motif; other site
99598002080	TPR repeat; Region: TPR_11; pfam13414
99598002081	TPR repeat; Region: TPR_11; pfam13414
99598002082	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598002083	binding surface
99598002084	TPR motif; other site
99598002085	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
99598002086	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
99598002087	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
99598002088	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
99598002089	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
99598002090	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
99598002091	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
99598002092	tetramer interface [polypeptide binding]; other site
99598002093	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598002094	catalytic residue [active]
99598002095	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
99598002096	MoaE interaction surface [polypeptide binding]; other site
99598002097	MoeB interaction surface [polypeptide binding]; other site
99598002098	thiocarboxylated glycine; other site
99598002099	threonine synthase; Validated; Region: PRK07591
99598002100	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
99598002101	homodimer interface [polypeptide binding]; other site
99598002102	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598002103	catalytic residue [active]
99598002104	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
99598002105	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
99598002106	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
99598002107	catalytic residues [active]
99598002108	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
99598002109	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99598002110	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598002111	homodimer interface [polypeptide binding]; other site
99598002112	catalytic residue [active]
99598002113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598002114	Response regulator receiver domain; Region: Response_reg; pfam00072
99598002115	active site
99598002116	phosphorylation site [posttranslational modification]
99598002117	intermolecular recognition site; other site
99598002118	dimerization interface [polypeptide binding]; other site
99598002119	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
99598002120	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
99598002121	GIY-YIG motif/motif A; other site
99598002122	active site
99598002123	catalytic site [active]
99598002124	putative DNA binding site [nucleotide binding]; other site
99598002125	metal binding site [ion binding]; metal-binding site
99598002126	UvrB/uvrC motif; Region: UVR; pfam02151
99598002127	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
99598002128	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
99598002129	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598002130	FeS/SAM binding site; other site
99598002131	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
99598002132	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
99598002133	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598002134	dimer interface [polypeptide binding]; other site
99598002135	phosphorylation site [posttranslational modification]
99598002136	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598002137	ATP binding site [chemical binding]; other site
99598002138	Mg2+ binding site [ion binding]; other site
99598002139	G-X-G motif; other site
99598002140	macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397
99598002141	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
99598002142	active site
99598002143	SAM binding site [chemical binding]; other site
99598002144	homodimer interface [polypeptide binding]; other site
99598002145	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
99598002146	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
99598002147	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
99598002148	active site
99598002149	(T/H)XGH motif; other site
99598002150	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
99598002151	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
99598002152	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
99598002153	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
99598002154	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
99598002155	ATP binding site [chemical binding]; other site
99598002156	putative Mg++ binding site [ion binding]; other site
99598002157	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598002158	nucleotide binding region [chemical binding]; other site
99598002159	ATP-binding site [chemical binding]; other site
99598002160	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
99598002161	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
99598002162	Walker A/P-loop; other site
99598002163	ATP binding site [chemical binding]; other site
99598002164	Q-loop/lid; other site
99598002165	ABC transporter signature motif; other site
99598002166	Walker B; other site
99598002167	D-loop; other site
99598002168	H-loop/switch region; other site
99598002169	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
99598002170	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
99598002171	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
99598002172	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
99598002173	TM-ABC transporter signature motif; other site
99598002174	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
99598002175	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
99598002176	active site
99598002177	dimer interface [polypeptide binding]; other site
99598002178	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
99598002179	dimer interface [polypeptide binding]; other site
99598002180	active site
99598002181	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
99598002182	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
99598002183	oligomer interface [polypeptide binding]; other site
99598002184	hypothetical protein; Reviewed; Region: PRK00024
99598002185	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
99598002186	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
99598002187	MPN+ (JAMM) motif; other site
99598002188	Zinc-binding site [ion binding]; other site
99598002189	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
99598002190	Protein export membrane protein; Region: SecD_SecF; cl14618
99598002191	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
99598002192	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598002193	CpeS-like protein; Region: CpeS; pfam09367
99598002194	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
99598002195	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598002196	putative active site [active]
99598002197	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
99598002198	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
99598002199	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
99598002200	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
99598002201	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
99598002202	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
99598002203	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
99598002204	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
99598002205	pantothenate kinase; Reviewed; Region: PRK13331
99598002206	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
99598002207	putative active site [active]
99598002208	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598002209	putative active site [active]
99598002210	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
99598002211	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
99598002212	catalytic site [active]
99598002213	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
99598002214	nudix motif; other site
99598002215	argininosuccinate lyase; Provisional; Region: PRK00855
99598002216	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
99598002217	active sites [active]
99598002218	tetramer interface [polypeptide binding]; other site
99598002219	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
99598002220	AIR carboxylase; Region: AIRC; smart01001
99598002221	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
99598002222	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
99598002223	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
99598002224	homotrimer interaction site [polypeptide binding]; other site
99598002225	zinc binding site [ion binding]; other site
99598002226	CDP-binding sites; other site
99598002227	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
99598002228	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
99598002229	proposed catalytic triad [active]
99598002230	active site nucleophile [active]
99598002231	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
99598002232	ATP-grasp domain; Region: ATP-grasp_4; cl17255
99598002233	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
99598002234	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
99598002235	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
99598002236	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598002237	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598002238	active site
99598002239	ATP binding site [chemical binding]; other site
99598002240	substrate binding site [chemical binding]; other site
99598002241	activation loop (A-loop); other site
99598002242	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
99598002243	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598002244	S-adenosylmethionine binding site [chemical binding]; other site
99598002245	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
99598002246	phosphatidate cytidylyltransferase; Region: PLN02953
99598002247	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
99598002248	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
99598002249	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99598002250	RNA binding surface [nucleotide binding]; other site
99598002251	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
99598002252	active site
99598002253	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
99598002254	Helix-turn-helix domain; Region: HTH_25; pfam13413
99598002255	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
99598002256	4-alpha-glucanotransferase; Provisional; Region: PRK14508
99598002257	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
99598002258	nudix motif; other site
99598002259	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598002260	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002261	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002262	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598002263	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002264	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
99598002265	homotrimer interaction site [polypeptide binding]; other site
99598002266	putative active site [active]
99598002267	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
99598002268	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
99598002269	M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343
99598002270	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
99598002271	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
99598002272	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
99598002273	protein binding site [polypeptide binding]; other site
99598002274	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
99598002275	Catalytic dyad [active]
99598002276	Uncharacterized conserved protein [Function unknown]; Region: COG1434
99598002277	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
99598002278	putative active site [active]
99598002279	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
99598002280	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
99598002281	Walker A/P-loop; other site
99598002282	ATP binding site [chemical binding]; other site
99598002283	Q-loop/lid; other site
99598002284	ABC transporter signature motif; other site
99598002285	Walker B; other site
99598002286	D-loop; other site
99598002287	H-loop/switch region; other site
99598002288	DevC protein; Region: devC; TIGR01185
99598002289	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
99598002290	FtsX-like permease family; Region: FtsX; pfam02687
99598002291	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
99598002292	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
99598002293	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598002294	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99598002295	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99598002296	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
99598002297	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
99598002298	active site
99598002299	NTP binding site [chemical binding]; other site
99598002300	metal binding triad [ion binding]; metal-binding site
99598002301	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
99598002302	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
99598002303	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
99598002304	S-layer homology domain; Region: SLH; pfam00395
99598002305	S-layer homology domain; Region: SLH; pfam00395
99598002306	S-layer homology domain; Region: SLH; pfam00395
99598002307	KWG Leptospira; Region: KWG; pfam07656
99598002308	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
99598002309	KWG Leptospira; Region: KWG; pfam07656
99598002310	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
99598002311	Glycoprotease family; Region: Peptidase_M22; pfam00814
99598002312	acetylornithine aminotransferase; Provisional; Region: PRK02627
99598002313	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
99598002314	inhibitor-cofactor binding pocket; inhibition site
99598002315	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598002316	catalytic residue [active]
99598002317	Ion channel; Region: Ion_trans_2; pfam07885
99598002318	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
99598002319	TrkA-N domain; Region: TrkA_N; pfam02254
99598002320	TrkA-C domain; Region: TrkA_C; pfam02080
99598002321	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
99598002322	YcfA-like protein; Region: YcfA; pfam07927
99598002323	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
99598002324	magnesium chelatase subunit H; Provisional; Region: PLN03241
99598002325	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
99598002326	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
99598002327	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
99598002328	active site
99598002329	metal binding site [ion binding]; metal-binding site
99598002330	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
99598002331	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598002332	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598002333	hypothetical protein; Validated; Region: PRK00110
99598002334	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
99598002335	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
99598002336	Probable transposase; Region: OrfB_IS605; pfam01385
99598002337	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
99598002338	Transposase IS200 like; Region: Y1_Tnp; pfam01797
99598002339	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
99598002340	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
99598002341	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
99598002342	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
99598002343	structural tetrad; other site
99598002344	Cadherin repeat-like domain; Region: CA_like; cl15786
99598002345	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
99598002346	Ca2+ binding site [ion binding]; other site
99598002347	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
99598002348	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
99598002349	active site
99598002350	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
99598002351	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
99598002352	catalytic motif [active]
99598002353	Zn binding site [ion binding]; other site
99598002354	RibD C-terminal domain; Region: RibD_C; cl17279
99598002355	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
99598002356	rod shape-determining protein MreC; Provisional; Region: PRK13922
99598002357	rod shape-determining protein MreC; Region: MreC; pfam04085
99598002358	rod shape-determining protein MreB; Provisional; Region: PRK13927
99598002359	MreB and similar proteins; Region: MreB_like; cd10225
99598002360	nucleotide binding site [chemical binding]; other site
99598002361	Mg binding site [ion binding]; other site
99598002362	putative protofilament interaction site [polypeptide binding]; other site
99598002363	RodZ interaction site [polypeptide binding]; other site
99598002364	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
99598002365	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
99598002366	dimer interface [polypeptide binding]; other site
99598002367	ssDNA binding site [nucleotide binding]; other site
99598002368	tetramer (dimer of dimers) interface [polypeptide binding]; other site
99598002369	Uncharacterized conserved protein [Function unknown]; Region: COG2968
99598002370	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
99598002371	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
99598002372	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
99598002373	AMIN domain; Region: AMIN; pfam11741
99598002374	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
99598002375	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
99598002376	active site
99598002377	metal binding site [ion binding]; metal-binding site
99598002378	AMIN domain; Region: AMIN; pfam11741
99598002379	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
99598002380	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
99598002381	active site
99598002382	metal binding site [ion binding]; metal-binding site
99598002383	glutamate racemase; Provisional; Region: PRK00865
99598002384	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
99598002385	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
99598002386	substrate binding pocket [chemical binding]; other site
99598002387	chain length determination region; other site
99598002388	substrate-Mg2+ binding site; other site
99598002389	catalytic residues [active]
99598002390	aspartate-rich region 1; other site
99598002391	active site lid residues [active]
99598002392	aspartate-rich region 2; other site
99598002393	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
99598002394	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
99598002395	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
99598002396	hypothetical protein; Provisional; Region: PRK04323
99598002397	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
99598002398	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
99598002399	catalytic site [active]
99598002400	G-X2-G-X-G-K; other site
99598002401	Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605
99598002402	photosystem I reaction center subunit IX; Provisional; Region: PRK02733
99598002403	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
99598002404	UGMP family protein; Validated; Region: PRK09604
99598002405	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
99598002406	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
99598002407	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
99598002408	catalytic site [active]
99598002409	Fragile site-associated protein C-terminus; Region: FSA_C; pfam10479
99598002410	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
99598002411	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598002412	Coenzyme A binding pocket [chemical binding]; other site
99598002413	Tic22-like family; Region: Tic22; cl04468
99598002414	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
99598002415	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598002416	S-adenosylmethionine binding site [chemical binding]; other site
99598002417	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
99598002418	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598002419	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598002420	dimer interface [polypeptide binding]; other site
99598002421	phosphorylation site [posttranslational modification]
99598002422	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
99598002423	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598002424	Coenzyme A binding pocket [chemical binding]; other site
99598002425	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598002426	putative active site [active]
99598002427	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
99598002428	Protein export membrane protein; Region: SecD_SecF; pfam02355
99598002429	protein-export membrane protein SecD; Region: secD; TIGR01129
99598002430	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
99598002431	protein-export membrane protein SecD; Region: secD; TIGR01129
99598002432	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
99598002433	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
99598002434	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
99598002435	putative active site [active]
99598002436	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
99598002437	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
99598002438	alpha subunit interface [polypeptide binding]; other site
99598002439	TPP binding site [chemical binding]; other site
99598002440	heterodimer interface [polypeptide binding]; other site
99598002441	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
99598002442	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
99598002443	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
99598002444	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
99598002445	dimer interface [polypeptide binding]; other site
99598002446	active site
99598002447	Schiff base residues; other site
99598002448	Tic20-like protein; Region: Tic20; pfam09685
99598002449	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
99598002450	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
99598002451	G1 box; other site
99598002452	putative GEF interaction site [polypeptide binding]; other site
99598002453	GTP/Mg2+ binding site [chemical binding]; other site
99598002454	Switch I region; other site
99598002455	G2 box; other site
99598002456	G3 box; other site
99598002457	Switch II region; other site
99598002458	G4 box; other site
99598002459	G5 box; other site
99598002460	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
99598002461	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
99598002462	RNA recognition motif; Region: RRM; smart00360
99598002463	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
99598002464	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
99598002465	putative NAD(P) binding site [chemical binding]; other site
99598002466	active site
99598002467	Rubrerythrin [Energy production and conversion]; Region: COG1592
99598002468	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
99598002469	binuclear metal center [ion binding]; other site
99598002470	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
99598002471	iron binding site [ion binding]; other site
99598002472	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
99598002473	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99598002474	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598002475	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99598002476	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99598002477	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
99598002478	putative dimerization interface [polypeptide binding]; other site
99598002479	Domain of unknown function (DUF202); Region: DUF202; pfam02656
99598002480	phosphodiesterase YaeI; Provisional; Region: PRK11340
99598002481	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
99598002482	putative active site [active]
99598002483	putative metal binding site [ion binding]; other site
99598002484	phosphodiesterase YaeI; Provisional; Region: PRK11340
99598002485	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
99598002486	putative active site [active]
99598002487	putative metal binding site [ion binding]; other site
99598002488	Protein of unknown function DUF262; Region: DUF262; pfam03235
99598002489	Uncharacterized conserved protein [Function unknown]; Region: COG1479
99598002490	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
99598002491	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598002492	putative active site [active]
99598002493	choline dehydrogenase; Validated; Region: PRK02106
99598002494	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
99598002495	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
99598002496	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
99598002497	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598002498	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
99598002499	Walker A motif; other site
99598002500	ATP binding site [chemical binding]; other site
99598002501	Walker B motif; other site
99598002502	DEAD-like helicases superfamily; Region: DEXDc; smart00487
99598002503	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598002504	putative Mg++ binding site [ion binding]; other site
99598002505	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598002506	nucleotide binding region [chemical binding]; other site
99598002507	ATP-binding site [chemical binding]; other site
99598002508	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
99598002509	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
99598002510	four helix bundle protein; Region: TIGR02436
99598002511	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
99598002512	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
99598002513	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598002514	active site
99598002515	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
99598002516	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598002517	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
99598002518	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
99598002519	anti sigma factor interaction site; other site
99598002520	regulatory phosphorylation site [posttranslational modification]; other site
99598002521	Response regulator receiver domain; Region: Response_reg; pfam00072
99598002522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598002523	active site
99598002524	phosphorylation site [posttranslational modification]
99598002525	intermolecular recognition site; other site
99598002526	dimerization interface [polypeptide binding]; other site
99598002527	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
99598002528	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
99598002529	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
99598002530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
99598002531	ATP binding site [chemical binding]; other site
99598002532	Mg2+ binding site [ion binding]; other site
99598002533	G-X-G motif; other site
99598002534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598002535	ATP binding site [chemical binding]; other site
99598002536	Mg2+ binding site [ion binding]; other site
99598002537	G-X-G motif; other site
99598002538	Response regulator receiver domain; Region: Response_reg; pfam00072
99598002539	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598002540	active site
99598002541	phosphorylation site [posttranslational modification]
99598002542	intermolecular recognition site; other site
99598002543	dimerization interface [polypeptide binding]; other site
99598002544	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
99598002545	putative binding surface; other site
99598002546	active site
99598002547	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
99598002548	AAA ATPase domain; Region: AAA_16; pfam13191
99598002549	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
99598002550	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
99598002551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598002552	Walker A motif; other site
99598002553	ATP binding site [chemical binding]; other site
99598002554	Walker B motif; other site
99598002555	Transmembrane proteins 14C; Region: Tmemb_14; cl02346
99598002556	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
99598002557	catalytic core [active]
99598002558	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
99598002559	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
99598002560	Protein of unknown function (DUF433); Region: DUF433; cl01030
99598002561	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
99598002562	XisH protein; Region: XisH; pfam08814
99598002563	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
99598002564	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
99598002565	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
99598002566	substrate binding pocket [chemical binding]; other site
99598002567	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
99598002568	B12 binding site [chemical binding]; other site
99598002569	cobalt ligand [ion binding]; other site
99598002570	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
99598002571	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
99598002572	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
99598002573	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
99598002574	protein binding site [polypeptide binding]; other site
99598002575	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
99598002576	putative homodimer interface [polypeptide binding]; other site
99598002577	putative homotetramer interface [polypeptide binding]; other site
99598002578	putative metal binding site [ion binding]; other site
99598002579	putative homodimer-homodimer interface [polypeptide binding]; other site
99598002580	putative allosteric switch controlling residues; other site
99598002581	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
99598002582	putative active site [active]
99598002583	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
99598002584	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
99598002585	N-acetyl-D-glucosamine binding site [chemical binding]; other site
99598002586	catalytic residue [active]
99598002587	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
99598002588	NADH(P)-binding; Region: NAD_binding_10; pfam13460
99598002589	NAD(P) binding site [chemical binding]; other site
99598002590	putative active site [active]
99598002591	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
99598002592	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
99598002593	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
99598002594	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
99598002595	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
99598002596	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
99598002597	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
99598002598	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
99598002599	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
99598002600	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
99598002601	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
99598002602	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
99598002603	Membrane protein of unknown function; Region: DUF360; cl00850
99598002604	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598002605	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598002606	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
99598002607	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
99598002608	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
99598002609	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
99598002610	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
99598002611	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
99598002612	valyl-tRNA synthetase; Region: valS; TIGR00422
99598002613	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
99598002614	active site
99598002615	HIGH motif; other site
99598002616	nucleotide binding site [chemical binding]; other site
99598002617	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
99598002618	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
99598002619	active site
99598002620	KMSKS motif; other site
99598002621	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
99598002622	tRNA binding surface [nucleotide binding]; other site
99598002623	anticodon binding site; other site
99598002624	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
99598002625	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
99598002626	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
99598002627	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
99598002628	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
99598002629	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
99598002630	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99598002631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598002632	active site
99598002633	phosphorylation site [posttranslational modification]
99598002634	intermolecular recognition site; other site
99598002635	dimerization interface [polypeptide binding]; other site
99598002636	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99598002637	DNA binding site [nucleotide binding]
99598002638	bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424
99598002639	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
99598002640	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99598002641	NAD(P) binding site [chemical binding]; other site
99598002642	active site
99598002643	ATP-grasp domain; Region: ATP-grasp_4; cl17255
99598002644	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
99598002645	ArsC family; Region: ArsC; pfam03960
99598002646	catalytic residue [active]
99598002647	Staphylococcal nuclease homologues; Region: SNc; smart00318
99598002648	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
99598002649	Catalytic site; other site
99598002650	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
99598002651	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
99598002652	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
99598002653	dimerization interface [polypeptide binding]; other site
99598002654	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598002655	dimer interface [polypeptide binding]; other site
99598002656	phosphorylation site [posttranslational modification]
99598002657	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598002658	ATP binding site [chemical binding]; other site
99598002659	Mg2+ binding site [ion binding]; other site
99598002660	G-X-G motif; other site
99598002661	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
99598002662	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598002663	membrane-bound complex binding site; other site
99598002664	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598002665	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
99598002666	membrane-bound complex binding site; other site
99598002667	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
99598002668	Low molecular weight phosphatase family; Region: LMWPc; cd00115
99598002669	active site
99598002670	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
99598002671	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
99598002672	putative metal binding site [ion binding]; other site
99598002673	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
99598002674	arsenical-resistance protein; Region: acr3; TIGR00832
99598002675	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598002676	putative substrate translocation pore; other site
99598002677	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
99598002678	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
99598002679	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
99598002680	PBP superfamily domain; Region: PBP_like_2; cl17296
99598002681	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
99598002682	dimerization interface [polypeptide binding]; other site
99598002683	putative DNA binding site [nucleotide binding]; other site
99598002684	putative Zn2+ binding site [ion binding]; other site
99598002685	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
99598002686	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
99598002687	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
99598002688	aspartate aminotransferase; Provisional; Region: PRK05942
99598002689	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99598002690	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598002691	homodimer interface [polypeptide binding]; other site
99598002692	catalytic residue [active]
99598002693	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
99598002694	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
99598002695	putative active site [active]
99598002696	metal binding site [ion binding]; metal-binding site
99598002697	Protein of function (DUF2518); Region: DUF2518; pfam10726
99598002698	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
99598002699	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99598002700	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598002701	homodimer interface [polypeptide binding]; other site
99598002702	catalytic residue [active]
99598002703	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598002704	putative active site [active]
99598002705	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598002706	putative active site [active]
99598002707	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837
99598002708	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
99598002709	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
99598002710	Probable Catalytic site; other site
99598002711	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
99598002712	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
99598002713	Cysteine-rich domain; Region: CCG; pfam02754
99598002714	Cysteine-rich domain; Region: CCG; pfam02754
99598002715	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
99598002716	FAD binding domain; Region: FAD_binding_4; pfam01565
99598002717	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
99598002718	FOG: CBS domain [General function prediction only]; Region: COG0517
99598002719	PAS fold; Region: PAS_4; pfam08448
99598002720	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598002721	GAF domain; Region: GAF; cl17456
99598002722	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598002723	PAS fold; Region: PAS_3; pfam08447
99598002724	putative active site [active]
99598002725	heme pocket [chemical binding]; other site
99598002726	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
99598002727	Histidine kinase; Region: HisKA_2; pfam07568
99598002728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598002729	ATP binding site [chemical binding]; other site
99598002730	Mg2+ binding site [ion binding]; other site
99598002731	G-X-G motif; other site
99598002732	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598002733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598002734	active site
99598002735	phosphorylation site [posttranslational modification]
99598002736	intermolecular recognition site; other site
99598002737	dimerization interface [polypeptide binding]; other site
99598002738	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598002739	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598002740	dimer interface [polypeptide binding]; other site
99598002741	phosphorylation site [posttranslational modification]
99598002742	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598002743	ATP binding site [chemical binding]; other site
99598002744	Mg2+ binding site [ion binding]; other site
99598002745	G-X-G motif; other site
99598002746	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
99598002747	Class I aldolases; Region: Aldolase_Class_I; cl17187
99598002748	catalytic residue [active]
99598002749	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
99598002750	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
99598002751	Amidohydrolase; Region: Amidohydro_2; pfam04909
99598002752	GxxExxY protein; Region: GxxExxY; TIGR04256
99598002753	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
99598002754	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
99598002755	active site
99598002756	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
99598002757	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
99598002758	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
99598002759	N-terminal domain interface [polypeptide binding]; other site
99598002760	dimer interface [polypeptide binding]; other site
99598002761	substrate binding pocket (H-site) [chemical binding]; other site
99598002762	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
99598002763	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
99598002764	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
99598002765	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
99598002766	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
99598002767	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99598002768	DNA binding residues [nucleotide binding]
99598002769	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598002770	putative active site [active]
99598002771	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598002772	binding surface
99598002773	TPR motif; other site
99598002774	TPR repeat; Region: TPR_11; pfam13414
99598002775	TPR repeat; Region: TPR_11; pfam13414
99598002776	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598002777	binding surface
99598002778	TPR motif; other site
99598002779	TPR repeat; Region: TPR_11; pfam13414
99598002780	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598002781	binding surface
99598002782	TPR motif; other site
99598002783	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598002784	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
99598002785	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
99598002786	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
99598002787	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
99598002788	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
99598002789	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
99598002790	Uncharacterized conserved protein [Function unknown]; Region: COG1432
99598002791	LabA_like proteins; Region: LabA; cd10911
99598002792	putative metal binding site [ion binding]; other site
99598002793	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99598002794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598002795	active site
99598002796	phosphorylation site [posttranslational modification]
99598002797	intermolecular recognition site; other site
99598002798	dimerization interface [polypeptide binding]; other site
99598002799	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99598002800	DNA binding site [nucleotide binding]
99598002801	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598002802	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598002803	dimerization interface [polypeptide binding]; other site
99598002804	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598002805	dimer interface [polypeptide binding]; other site
99598002806	phosphorylation site [posttranslational modification]
99598002807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598002808	ATP binding site [chemical binding]; other site
99598002809	Mg2+ binding site [ion binding]; other site
99598002810	G-X-G motif; other site
99598002811	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598002812	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598002813	active site
99598002814	ATP binding site [chemical binding]; other site
99598002815	substrate binding site [chemical binding]; other site
99598002816	activation loop (A-loop); other site
99598002817	Uncharacterized conserved protein [Function unknown]; Region: COG1262
99598002818	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
99598002819	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
99598002820	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
99598002821	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
99598002822	protein binding site [polypeptide binding]; other site
99598002823	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
99598002824	proposed catalytic triad [active]
99598002825	active site nucleophile [active]
99598002826	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
99598002827	16S/18S rRNA binding site [nucleotide binding]; other site
99598002828	S13e-L30e interaction site [polypeptide binding]; other site
99598002829	25S rRNA binding site [nucleotide binding]; other site
99598002830	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
99598002831	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
99598002832	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
99598002833	Predicted transcriptional regulators [Transcription]; Region: COG1695
99598002834	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
99598002835	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
99598002836	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598002837	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002838	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
99598002839	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002840	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002841	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002842	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002843	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002844	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002845	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002846	arogenate dehydrogenase; Reviewed; Region: PRK07417
99598002847	prephenate dehydrogenase; Validated; Region: PRK08507
99598002848	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
99598002849	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598002850	Coenzyme A binding pocket [chemical binding]; other site
99598002851	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598002852	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002853	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598002854	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598002855	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
99598002856	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
99598002857	metal binding site [ion binding]; metal-binding site
99598002858	dimer interface [polypeptide binding]; other site
99598002859	Hemerythrin-like domain; Region: Hr-like; cd12108
99598002860	Fe binding site [ion binding]; other site
99598002861	Predicted membrane protein [Function unknown]; Region: COG4244
99598002862	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
99598002863	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
99598002864	FMN binding site [chemical binding]; other site
99598002865	active site
99598002866	catalytic residues [active]
99598002867	substrate binding site [chemical binding]; other site
99598002868	Uncharacterized conserved protein [Function unknown]; Region: COG3791
99598002869	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
99598002870	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
99598002871	homodimer interface [polypeptide binding]; other site
99598002872	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598002873	catalytic residue [active]
99598002874	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
99598002875	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
99598002876	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99598002877	metal binding site [ion binding]; metal-binding site
99598002878	active site
99598002879	I-site; other site
99598002880	Peptidase family M41; Region: Peptidase_M41; pfam01434
99598002881	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
99598002882	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
99598002883	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
99598002884	putative active site [active]
99598002885	putative substrate binding site [chemical binding]; other site
99598002886	putative cosubstrate binding site; other site
99598002887	catalytic site [active]
99598002888	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
99598002889	ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225
99598002890	Protein of unknown function (DUF423); Region: DUF423; cl01008
99598002891	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
99598002892	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
99598002893	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598002894	Walker A/P-loop; other site
99598002895	ATP binding site [chemical binding]; other site
99598002896	Q-loop/lid; other site
99598002897	ABC transporter signature motif; other site
99598002898	Walker B; other site
99598002899	D-loop; other site
99598002900	H-loop/switch region; other site
99598002901	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
99598002902	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
99598002903	NAD(P) binding site [chemical binding]; other site
99598002904	homotetramer interface [polypeptide binding]; other site
99598002905	homodimer interface [polypeptide binding]; other site
99598002906	active site
99598002907	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
99598002908	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
99598002909	Mg++ binding site [ion binding]; other site
99598002910	putative catalytic motif [active]
99598002911	substrate binding site [chemical binding]; other site
99598002912	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
99598002913	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
99598002914	ring oligomerisation interface [polypeptide binding]; other site
99598002915	ATP/Mg binding site [chemical binding]; other site
99598002916	stacking interactions; other site
99598002917	hinge regions; other site
99598002918	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
99598002919	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
99598002920	oligomer interface [polypeptide binding]; other site
99598002921	metal binding site [ion binding]; metal-binding site
99598002922	metal binding site [ion binding]; metal-binding site
99598002923	Cl binding site [ion binding]; other site
99598002924	aspartate ring; other site
99598002925	basic sphincter; other site
99598002926	putative hydrophobic gate; other site
99598002927	periplasmic entrance; other site
99598002928	4-aminobutyrate aminotransferase; Provisional; Region: PRK05769
99598002929	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
99598002930	inhibitor-cofactor binding pocket; inhibition site
99598002931	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598002932	catalytic residue [active]
99598002933	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
99598002934	proton extrusion protein PcxA; Provisional; Region: PRK02507
99598002935	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
99598002936	active site clefts [active]
99598002937	zinc binding site [ion binding]; other site
99598002938	dimer interface [polypeptide binding]; other site
99598002939	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
99598002940	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
99598002941	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
99598002942	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
99598002943	catalytic motif [active]
99598002944	Catalytic residue [active]
99598002945	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
99598002946	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
99598002947	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
99598002948	catalytic site [active]
99598002949	subunit interface [polypeptide binding]; other site
99598002950	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
99598002951	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
99598002952	anti sigma factor interaction site; other site
99598002953	regulatory phosphorylation site [posttranslational modification]; other site
99598002954	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
99598002955	active site
99598002956	metal binding site [ion binding]; metal-binding site
99598002957	dimerization interface [polypeptide binding]; other site
99598002958	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
99598002959	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
99598002960	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
99598002961	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
99598002962	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
99598002963	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
99598002964	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
99598002965	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
99598002966	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
99598002967	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
99598002968	S-layer homology domain; Region: SLH; pfam00395
99598002969	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
99598002970	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
99598002971	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
99598002972	S-layer homology domain; Region: SLH; pfam00395
99598002973	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
99598002974	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
99598002975	active site
99598002976	metal binding site [ion binding]; metal-binding site
99598002977	interdomain interaction site; other site
99598002978	Virulence-associated protein E; Region: VirE; pfam05272
99598002979	KGK domain; Region: KGK; pfam08872
99598002980	oxidoreductase; Provisional; Region: PRK08017
99598002981	seryl-tRNA synthetase; Provisional; Region: PRK05431
99598002982	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
99598002983	Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107
99598002984	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
99598002985	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
99598002986	active site
99598002987	catalytic residues [active]
99598002988	DNA binding site [nucleotide binding]
99598002989	Int/Topo IB signature motif; other site
99598002990	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
99598002991	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
99598002992	molybdopterin cofactor binding site; other site
99598002993	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
99598002994	molybdopterin cofactor binding site; other site
99598002995	sensory histidine kinase AtoS; Provisional; Region: PRK11360
99598002996	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
99598002997	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
99598002998	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
99598002999	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
99598003000	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
99598003001	dimer interface [polypeptide binding]; other site
99598003002	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
99598003003	active site
99598003004	Fe binding site [ion binding]; other site
99598003005	Caspase domain; Region: Peptidase_C14; pfam00656
99598003006	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
99598003007	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
99598003008	CHASE2 domain; Region: CHASE2; pfam05226
99598003009	CHAT domain; Region: CHAT; pfam12770
99598003010	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
99598003011	TPR motif; other site
99598003012	TPR repeat; Region: TPR_11; pfam13414
99598003013	binding surface
99598003014	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598003015	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598003016	binding surface
99598003017	TPR motif; other site
99598003018	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598003019	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598003020	binding surface
99598003021	TPR motif; other site
99598003022	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598003023	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598003024	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598003025	TPR motif; other site
99598003026	binding surface
99598003027	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598003028	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598003029	CHAT domain; Region: CHAT; pfam12770
99598003030	Homeodomain-like domain; Region: HTH_23; pfam13384
99598003031	Winged helix-turn helix; Region: HTH_29; pfam13551
99598003032	HTH-like domain; Region: HTH_21; pfam13276
99598003033	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598003034	ligand binding site [chemical binding]; other site
99598003035	flexible hinge region; other site
99598003036	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
99598003037	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
99598003038	putative active site [active]
99598003039	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598003040	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
99598003041	Walker A/P-loop; other site
99598003042	ATP binding site [chemical binding]; other site
99598003043	Q-loop/lid; other site
99598003044	ABC transporter signature motif; other site
99598003045	Walker B; other site
99598003046	D-loop; other site
99598003047	H-loop/switch region; other site
99598003048	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
99598003049	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99598003050	Predicted coiled-coil domain-containing protein; Region: TTKRSYEDQ; pfam10212
99598003051	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598003052	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
99598003053	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
99598003054	Uncharacterized conserved protein [Function unknown]; Region: COG2898
99598003055	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
99598003056	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
99598003057	Putative esterase; Region: Esterase; pfam00756
99598003058	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
99598003059	alpha-dioxygenase; Region: PLN02283
99598003060	Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818
99598003061	putative heme binding site [chemical binding]; other site
99598003062	putative active site [active]
99598003063	putative substrate binding site [chemical binding]; other site
99598003064	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
99598003065	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
99598003066	elongation factor G; Reviewed; Region: PRK00007
99598003067	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
99598003068	G1 box; other site
99598003069	putative GEF interaction site [polypeptide binding]; other site
99598003070	GTP/Mg2+ binding site [chemical binding]; other site
99598003071	Switch I region; other site
99598003072	G2 box; other site
99598003073	G3 box; other site
99598003074	Switch II region; other site
99598003075	G4 box; other site
99598003076	G5 box; other site
99598003077	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
99598003078	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
99598003079	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
99598003080	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
99598003081	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
99598003082	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
99598003083	putative catalytic site [active]
99598003084	putative metal binding site [ion binding]; other site
99598003085	putative phosphate binding site [ion binding]; other site
99598003086	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
99598003087	Phosphoglycerate kinase; Region: PGK; pfam00162
99598003088	substrate binding site [chemical binding]; other site
99598003089	hinge regions; other site
99598003090	ADP binding site [chemical binding]; other site
99598003091	catalytic site [active]
99598003092	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99598003093	Ligand Binding Site [chemical binding]; other site
99598003094	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
99598003095	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598003096	active site
99598003097	ATP binding site [chemical binding]; other site
99598003098	substrate binding site [chemical binding]; other site
99598003099	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
99598003100	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598003101	TPR motif; other site
99598003102	TPR repeat; Region: TPR_11; pfam13414
99598003103	binding surface
99598003104	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
99598003105	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
99598003106	TPR repeat; Region: TPR_11; pfam13414
99598003107	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598003108	binding surface
99598003109	Protein of unknown function DUF82; Region: DUF82; pfam01927
99598003110	Protein of unknown function (DUF433); Region: DUF433; pfam04255
99598003111	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598003112	PAS domain; Region: PAS; smart00091
99598003113	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598003114	putative active site [active]
99598003115	heme pocket [chemical binding]; other site
99598003116	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598003117	putative active site [active]
99598003118	heme pocket [chemical binding]; other site
99598003119	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598003120	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598003121	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598003122	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598003123	ATP binding site [chemical binding]; other site
99598003124	Mg2+ binding site [ion binding]; other site
99598003125	G-X-G motif; other site
99598003126	PAS domain S-box; Region: sensory_box; TIGR00229
99598003127	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598003128	putative active site [active]
99598003129	heme pocket [chemical binding]; other site
99598003130	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598003131	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598003132	dimer interface [polypeptide binding]; other site
99598003133	phosphorylation site [posttranslational modification]
99598003134	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598003135	ATP binding site [chemical binding]; other site
99598003136	Mg2+ binding site [ion binding]; other site
99598003137	G-X-G motif; other site
99598003138	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
99598003139	dimer interface [polypeptide binding]; other site
99598003140	catalytic triad [active]
99598003141	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807
99598003142	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
99598003143	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
99598003144	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
99598003145	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
99598003146	Protein of unknown function (DUF1838); Region: DUF1838; pfam08894
99598003147	PBP superfamily domain; Region: PBP_like_2; cl17296
99598003148	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
99598003149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598003150	dimer interface [polypeptide binding]; other site
99598003151	conserved gate region; other site
99598003152	putative PBP binding loops; other site
99598003153	ABC-ATPase subunit interface; other site
99598003154	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
99598003155	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598003156	dimer interface [polypeptide binding]; other site
99598003157	conserved gate region; other site
99598003158	putative PBP binding loops; other site
99598003159	ABC-ATPase subunit interface; other site
99598003160	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14260
99598003161	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
99598003162	Walker A/P-loop; other site
99598003163	ATP binding site [chemical binding]; other site
99598003164	Q-loop/lid; other site
99598003165	ABC transporter signature motif; other site
99598003166	Walker B; other site
99598003167	D-loop; other site
99598003168	H-loop/switch region; other site
99598003169	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14258
99598003170	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
99598003171	Walker A/P-loop; other site
99598003172	ATP binding site [chemical binding]; other site
99598003173	Q-loop/lid; other site
99598003174	ABC transporter signature motif; other site
99598003175	Walker B; other site
99598003176	D-loop; other site
99598003177	H-loop/switch region; other site
99598003178	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
99598003179	NYN domain; Region: NYN; pfam01936
99598003180	classical (c) SDRs; Region: SDR_c; cd05233
99598003181	NAD(P) binding site [chemical binding]; other site
99598003182	active site
99598003183	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
99598003184	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598003185	motif II; other site
99598003186	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
99598003187	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99598003188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598003189	active site
99598003190	phosphorylation site [posttranslational modification]
99598003191	intermolecular recognition site; other site
99598003192	dimerization interface [polypeptide binding]; other site
99598003193	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99598003194	DNA binding site [nucleotide binding]
99598003195	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
99598003196	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
99598003197	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
99598003198	AMIN domain; Region: AMIN; pfam11741
99598003199	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
99598003200	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99598003201	N-terminal plug; other site
99598003202	ligand-binding site [chemical binding]; other site
99598003203	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
99598003204	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
99598003205	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
99598003206	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
99598003207	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
99598003208	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
99598003209	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
99598003210	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
99598003211	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
99598003212	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
99598003213	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
99598003214	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
99598003215	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
99598003216	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
99598003217	Walker A/P-loop; other site
99598003218	ATP binding site [chemical binding]; other site
99598003219	Q-loop/lid; other site
99598003220	ABC transporter signature motif; other site
99598003221	Walker B; other site
99598003222	D-loop; other site
99598003223	H-loop/switch region; other site
99598003224	TOBE domain; Region: TOBE_2; pfam08402
99598003225	hypothetical protein; Reviewed; Region: PRK12275
99598003226	four helix bundle protein; Region: TIGR02436
99598003227	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
99598003228	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
99598003229	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
99598003230	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598003231	dimer interface [polypeptide binding]; other site
99598003232	conserved gate region; other site
99598003233	putative PBP binding loops; other site
99598003234	ABC-ATPase subunit interface; other site
99598003235	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
99598003236	putative binding surface; other site
99598003237	active site
99598003238	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
99598003239	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598003240	ATP binding site [chemical binding]; other site
99598003241	Mg2+ binding site [ion binding]; other site
99598003242	G-X-G motif; other site
99598003243	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
99598003244	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598003245	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598003246	active site
99598003247	phosphorylation site [posttranslational modification]
99598003248	intermolecular recognition site; other site
99598003249	dimerization interface [polypeptide binding]; other site
99598003250	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598003251	GAF domain; Region: GAF; pfam01590
99598003252	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598003253	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598003254	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598003255	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598003256	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598003257	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598003258	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
99598003259	dimerization interface [polypeptide binding]; other site
99598003260	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
99598003261	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
99598003262	dimer interface [polypeptide binding]; other site
99598003263	putative CheW interface [polypeptide binding]; other site
99598003264	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
99598003265	Response regulator receiver domain; Region: Response_reg; pfam00072
99598003266	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598003267	active site
99598003268	phosphorylation site [posttranslational modification]
99598003269	intermolecular recognition site; other site
99598003270	dimerization interface [polypeptide binding]; other site
99598003271	Response regulator receiver domain; Region: Response_reg; pfam00072
99598003272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598003273	active site
99598003274	phosphorylation site [posttranslational modification]
99598003275	intermolecular recognition site; other site
99598003276	dimerization interface [polypeptide binding]; other site
99598003277	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
99598003278	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
99598003279	putative active site [active]
99598003280	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
99598003281	Family of unknown function (DUF490); Region: DUF490; pfam04357
99598003282	Predicted transcriptional regulator [Transcription]; Region: COG2378
99598003283	WYL domain; Region: WYL; pfam13280
99598003284	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
99598003285	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
99598003286	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
99598003287	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
99598003288	CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711
99598003289	CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159
99598003290	CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869
99598003291	CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712
99598003292	CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174
99598003293	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
99598003294	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
99598003295	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
99598003296	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598003297	substrate binding pocket [chemical binding]; other site
99598003298	membrane-bound complex binding site; other site
99598003299	hinge residues; other site
99598003300	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
99598003301	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598003302	substrate binding pocket [chemical binding]; other site
99598003303	membrane-bound complex binding site; other site
99598003304	hinge residues; other site
99598003305	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
99598003306	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598003307	substrate binding pocket [chemical binding]; other site
99598003308	membrane-bound complex binding site; other site
99598003309	hinge residues; other site
99598003310	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598003311	S-adenosylmethionine binding site [chemical binding]; other site
99598003312	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
99598003313	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598003314	substrate binding pocket [chemical binding]; other site
99598003315	membrane-bound complex binding site; other site
99598003316	hinge residues; other site
99598003317	Ferredoxin [Energy production and conversion]; Region: COG1146
99598003318	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
99598003319	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
99598003320	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
99598003321	S-layer homology domain; Region: SLH; pfam00395
99598003322	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
99598003323	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
99598003324	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598003325	dimer interface [polypeptide binding]; other site
99598003326	conserved gate region; other site
99598003327	putative PBP binding loops; other site
99598003328	ABC-ATPase subunit interface; other site
99598003329	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
99598003330	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
99598003331	Walker A/P-loop; other site
99598003332	ATP binding site [chemical binding]; other site
99598003333	Q-loop/lid; other site
99598003334	ABC transporter signature motif; other site
99598003335	Walker B; other site
99598003336	D-loop; other site
99598003337	H-loop/switch region; other site
99598003338	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
99598003339	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
99598003340	NAD binding site [chemical binding]; other site
99598003341	ligand binding site [chemical binding]; other site
99598003342	catalytic site [active]
99598003343	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
99598003344	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
99598003345	NAD binding site [chemical binding]; other site
99598003346	ligand binding site [chemical binding]; other site
99598003347	catalytic site [active]
99598003348	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598003349	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598003350	active site
99598003351	ATP binding site [chemical binding]; other site
99598003352	substrate binding site [chemical binding]; other site
99598003353	activation loop (A-loop); other site
99598003354	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
99598003355	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
99598003356	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
99598003357	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
99598003358	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
99598003359	active site
99598003360	hypothetical protein; Provisional; Region: PRK06208
99598003361	intersubunit interface [polypeptide binding]; other site
99598003362	active site
99598003363	Zn2+ binding site [ion binding]; other site
99598003364	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
99598003365	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
99598003366	dimer interface [polypeptide binding]; other site
99598003367	active site
99598003368	non-prolyl cis peptide bond; other site
99598003369	insertion regions; other site
99598003370	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
99598003371	Probable transposase; Region: OrfB_IS605; pfam01385
99598003372	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
99598003373	Uncharacterized conserved protein (DUF2349); Region: DUF2349; pfam09779
99598003374	Transposase IS200 like; Region: Y1_Tnp; pfam01797
99598003375	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
99598003376	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
99598003377	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
99598003378	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598003379	membrane-bound complex binding site; other site
99598003380	hinge residues; other site
99598003381	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
99598003382	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
99598003383	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
99598003384	Walker A/P-loop; other site
99598003385	ATP binding site [chemical binding]; other site
99598003386	Q-loop/lid; other site
99598003387	ABC transporter signature motif; other site
99598003388	Walker B; other site
99598003389	D-loop; other site
99598003390	H-loop/switch region; other site
99598003391	NIL domain; Region: NIL; pfam09383
99598003392	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
99598003393	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
99598003394	active site
99598003395	non-prolyl cis peptide bond; other site
99598003396	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
99598003397	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
99598003398	active site
99598003399	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598003400	dimer interface [polypeptide binding]; other site
99598003401	conserved gate region; other site
99598003402	ABC-ATPase subunit interface; other site
99598003403	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
99598003404	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598003405	putative substrate translocation pore; other site
99598003406	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
99598003407	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
99598003408	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
99598003409	active site
99598003410	FMN binding site [chemical binding]; other site
99598003411	substrate binding site [chemical binding]; other site
99598003412	homotetramer interface [polypeptide binding]; other site
99598003413	catalytic residue [active]
99598003414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598003415	H+ Antiporter protein; Region: 2A0121; TIGR00900
99598003416	putative substrate translocation pore; other site
99598003417	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
99598003418	active site
99598003419	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99598003420	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
99598003421	active site
99598003422	catalytic tetrad [active]
99598003423	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
99598003424	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598003425	substrate binding pocket [chemical binding]; other site
99598003426	membrane-bound complex binding site; other site
99598003427	hinge residues; other site
99598003428	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
99598003429	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598003430	putative active site [active]
99598003431	Protein of unknown function (DUF1517); Region: DUF1517; pfam07466
99598003432	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598003433	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
99598003434	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
99598003435	thiS-thiF/thiG interaction site; other site
99598003436	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
99598003437	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
99598003438	thiamine phosphate binding site [chemical binding]; other site
99598003439	active site
99598003440	pyrophosphate binding site [ion binding]; other site
99598003441	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
99598003442	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598003443	putative active site [active]
99598003444	heme pocket [chemical binding]; other site
99598003445	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598003446	putative active site [active]
99598003447	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14964
99598003448	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
99598003449	GIY-YIG motif/motif A; other site
99598003450	putative active site [active]
99598003451	putative metal binding site [ion binding]; other site
99598003452	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
99598003453	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
99598003454	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
99598003455	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
99598003456	Predicted ATPase [General function prediction only]; Region: COG4637
99598003457	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598003458	Walker A/P-loop; other site
99598003459	ATP binding site [chemical binding]; other site
99598003460	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598003461	ABC transporter signature motif; other site
99598003462	Walker B; other site
99598003463	D-loop; other site
99598003464	H-loop/switch region; other site
99598003465	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
99598003466	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
99598003467	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
99598003468	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598003469	ATP binding site [chemical binding]; other site
99598003470	putative Mg++ binding site [ion binding]; other site
99598003471	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
99598003472	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
99598003473	S-layer homology domain; Region: SLH; pfam00395
99598003474	S-layer homology domain; Region: SLH; pfam00395
99598003475	S-layer homology domain; Region: SLH; pfam00395
99598003476	S-layer homology domain; Region: SLH; pfam00395
99598003477	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
99598003478	Coenzyme A binding pocket [chemical binding]; other site
99598003479	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99598003480	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99598003481	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
99598003482	dimerization interface [polypeptide binding]; other site
99598003483	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
99598003484	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598003485	Coenzyme A binding pocket [chemical binding]; other site
99598003486	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
99598003487	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
99598003488	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
99598003489	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99598003490	DNA-binding site [nucleotide binding]; DNA binding site
99598003491	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99598003492	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598003493	homodimer interface [polypeptide binding]; other site
99598003494	catalytic residue [active]
99598003495	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
99598003496	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
99598003497	CHAT domain; Region: CHAT; cl17868
99598003498	TIR domain; Region: TIR_2; pfam13676
99598003499	WD domain, G-beta repeat; Region: WD40; pfam00400
99598003500	WD domain, G-beta repeat; Region: WD40; pfam00400
99598003501	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598003502	structural tetrad; other site
99598003503	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598003504	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598003505	structural tetrad; other site
99598003506	WD domain, G-beta repeat; Region: WD40; pfam00400
99598003507	WD domain, G-beta repeat; Region: WD40; pfam00400
99598003508	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
99598003509	active site
99598003510	DNA binding site [nucleotide binding]
99598003511	Int/Topo IB signature motif; other site
99598003512	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
99598003513	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
99598003514	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
99598003515	catalytic residues [active]
99598003516	catalytic nucleophile [active]
99598003517	His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978
99598003518	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
99598003519	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
99598003520	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598003521	motif II; other site
99598003522	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598003523	S-adenosylmethionine binding site [chemical binding]; other site
99598003524	Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401
99598003525	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
99598003526	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598003527	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598003528	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
99598003529	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
99598003530	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
99598003531	Cadmium resistance transporter; Region: Cad; pfam03596
99598003532	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
99598003533	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
99598003534	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
99598003535	active site
99598003536	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
99598003537	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
99598003538	CHAT domain; Region: CHAT; cl17868
99598003539	Ricin-type beta-trefoil; Region: RICIN; smart00458
99598003540	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
99598003541	putative sugar binding sites [chemical binding]; other site
99598003542	Q-X-W motif; other site
99598003543	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
99598003544	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
99598003545	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
99598003546	Walker A motif; other site
99598003547	ATP binding site [chemical binding]; other site
99598003548	Walker B motif; other site
99598003549	Homeodomain-like domain; Region: HTH_23; pfam13384
99598003550	Winged helix-turn helix; Region: HTH_29; pfam13551
99598003551	Bacterial SH3 domain; Region: SH3_3; cl17532
99598003552	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
99598003553	CHAT domain; Region: CHAT; cl17868
99598003554	CHASE2 domain; Region: CHASE2; pfam05226
99598003555	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
99598003556	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
99598003557	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99598003558	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
99598003559	DNA binding residues [nucleotide binding]
99598003560	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99598003561	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598003562	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
99598003563	Walker A/P-loop; other site
99598003564	ATP binding site [chemical binding]; other site
99598003565	Q-loop/lid; other site
99598003566	ABC transporter signature motif; other site
99598003567	Walker B; other site
99598003568	D-loop; other site
99598003569	H-loop/switch region; other site
99598003570	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
99598003571	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
99598003572	Cadmium resistance transporter; Region: Cad; pfam03596
99598003573	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
99598003574	Cadmium resistance transporter; Region: Cad; pfam03596
99598003575	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
99598003576	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
99598003577	dimer interface [polypeptide binding]; other site
99598003578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598003579	catalytic residue [active]
99598003580	Predicted transcriptional regulator [Transcription]; Region: COG1959
99598003581	Transcriptional regulator; Region: Rrf2; pfam02082
99598003582	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
99598003583	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
99598003584	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
99598003585	trimer interface [polypeptide binding]; other site
99598003586	active site
99598003587	substrate binding site [chemical binding]; other site
99598003588	CoA binding site [chemical binding]; other site
99598003589	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
99598003590	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
99598003591	Walker A/P-loop; other site
99598003592	ATP binding site [chemical binding]; other site
99598003593	Q-loop/lid; other site
99598003594	ABC transporter signature motif; other site
99598003595	Walker B; other site
99598003596	D-loop; other site
99598003597	H-loop/switch region; other site
99598003598	TOBE-like domain; Region: TOBE_3; pfam12857
99598003599	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598003600	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
99598003601	ligand binding site [chemical binding]; other site
99598003602	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
99598003603	putative switch regulator; other site
99598003604	non-specific DNA interactions [nucleotide binding]; other site
99598003605	DNA binding site [nucleotide binding]
99598003606	sequence specific DNA binding site [nucleotide binding]; other site
99598003607	putative cAMP binding site [chemical binding]; other site
99598003608	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
99598003609	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
99598003610	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
99598003611	sulfate transport protein; Provisional; Region: cysT; CHL00187
99598003612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598003613	dimer interface [polypeptide binding]; other site
99598003614	conserved gate region; other site
99598003615	putative PBP binding loops; other site
99598003616	ABC-ATPase subunit interface; other site
99598003617	sulfate transport protein; Provisional; Region: cysT; CHL00187
99598003618	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598003619	dimer interface [polypeptide binding]; other site
99598003620	conserved gate region; other site
99598003621	putative PBP binding loops; other site
99598003622	ABC-ATPase subunit interface; other site
99598003623	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
99598003624	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
99598003625	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
99598003626	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
99598003627	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
99598003628	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
99598003629	hypothetical protein; Provisional; Region: PRK10621
99598003630	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
99598003631	RNA binding activity-knot of a chromodomain; Region: Tudor-knot; pfam11717
99598003632	mbt repeat; Region: MBT; cl17705
99598003633	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
99598003634	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
99598003635	putative active site [active]
99598003636	putative dimer interface [polypeptide binding]; other site
99598003637	Uncharacterized conserved protein [Function unknown]; Region: COG1359
99598003638	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
99598003639	intersubunit interface [polypeptide binding]; other site
99598003640	active site
99598003641	Zn2+ binding site [ion binding]; other site
99598003642	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
99598003643	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598003644	active site
99598003645	motif I; other site
99598003646	motif II; other site
99598003647	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
99598003648	Cupin domain; Region: Cupin_2; cl17218
99598003649	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
99598003650	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
99598003651	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
99598003652	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
99598003653	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
99598003654	active site clefts [active]
99598003655	zinc binding site [ion binding]; other site
99598003656	dimer interface [polypeptide binding]; other site
99598003657	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
99598003658	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
99598003659	active site
99598003660	dimer interface [polypeptide binding]; other site
99598003661	non-prolyl cis peptide bond; other site
99598003662	insertion regions; other site
99598003663	MgtC family; Region: MgtC; pfam02308
99598003664	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
99598003665	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
99598003666	RNA binding site [nucleotide binding]; other site
99598003667	active site
99598003668	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
99598003669	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
99598003670	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99598003671	N-terminal plug; other site
99598003672	ligand-binding site [chemical binding]; other site
99598003673	isoleucyl-tRNA synthetase; Region: PLN02843
99598003674	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
99598003675	HIGH motif; other site
99598003676	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
99598003677	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
99598003678	active site
99598003679	KMSKS motif; other site
99598003680	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
99598003681	tRNA binding surface [nucleotide binding]; other site
99598003682	anticodon binding site; other site
99598003683	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
99598003684	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
99598003685	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
99598003686	catalytic residues [active]
99598003687	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598003688	binding surface
99598003689	TPR motif; other site
99598003690	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
99598003691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598003692	binding surface
99598003693	TPR motif; other site
99598003694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598003695	binding surface
99598003696	TPR motif; other site
99598003697	CHAT domain; Region: CHAT; cl17868
99598003698	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598003699	Walker A motif; other site
99598003700	ATP binding site [chemical binding]; other site
99598003701	Walker B motif; other site
99598003702	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
99598003703	protein-splicing catalytic site; other site
99598003704	thioester formation/cholesterol transfer; other site
99598003705	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
99598003706	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
99598003707	protein-splicing catalytic site; other site
99598003708	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
99598003709	DNA polymerase III subunit delta'; Validated; Region: PRK08485
99598003710	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
99598003711	zinc-finger of a C2HC-type; Region: zf-C2HC_2; pfam13913
99598003712	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
99598003713	Predicted transcriptional regulator [Transcription]; Region: COG3905
99598003714	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
99598003715	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
99598003716	DXD motif; other site
99598003717	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
99598003718	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598003719	non-specific DNA binding site [nucleotide binding]; other site
99598003720	salt bridge; other site
99598003721	sequence-specific DNA binding site [nucleotide binding]; other site
99598003722	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
99598003723	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
99598003724	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
99598003725	DRTGG domain; Region: DRTGG; pfam07085
99598003726	MAPEG family; Region: MAPEG; cl09190
99598003727	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
99598003728	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
99598003729	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
99598003730	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
99598003731	putative C-terminal domain interface [polypeptide binding]; other site
99598003732	putative GSH binding site (G-site) [chemical binding]; other site
99598003733	putative dimer interface [polypeptide binding]; other site
99598003734	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
99598003735	N-terminal domain interface [polypeptide binding]; other site
99598003736	dimer interface [polypeptide binding]; other site
99598003737	substrate binding pocket (H-site) [chemical binding]; other site
99598003738	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598003739	TPR repeat; Region: TPR_11; pfam13414
99598003740	binding surface
99598003741	TPR motif; other site
99598003742	TPR repeat; Region: TPR_11; pfam13414
99598003743	TPR repeat; Region: TPR_11; pfam13414
99598003744	Photosystem I protein M (PsaM); Region: PsaM; pfam07465
99598003745	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
99598003746	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
99598003747	nucleotide binding site [chemical binding]; other site
99598003748	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
99598003749	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
99598003750	muropeptide transporter; Reviewed; Region: ampG; PRK11902
99598003751	muropeptide transporter; Validated; Region: ampG; cl17669
99598003752	methionine sulfoxide reductase B; Provisional; Region: PRK00222
99598003753	SelR domain; Region: SelR; pfam01641
99598003754	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
99598003755	FOG: WD40-like repeat [Function unknown]; Region: COG1520
99598003756	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
99598003757	Cache domain; Region: Cache_1; pfam02743
99598003758	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598003759	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598003760	ATP binding site [chemical binding]; other site
99598003761	Mg2+ binding site [ion binding]; other site
99598003762	G-X-G motif; other site
99598003763	thymidylate kinase; Validated; Region: tmk; PRK00698
99598003764	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
99598003765	TMP-binding site; other site
99598003766	ATP-binding site [chemical binding]; other site
99598003767	Peptidase family M48; Region: Peptidase_M48; cl12018
99598003768	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
99598003769	Protein of unknown function (DUF433); Region: DUF433; pfam04255
99598003770	XisI protein; Region: XisI; pfam08869
99598003771	XisH protein; Region: XisH; pfam08814
99598003772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
99598003773	Protein of unknown function (DUF433); Region: DUF433; pfam04255
99598003774	CHAT domain; Region: CHAT; cl17868
99598003775	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598003776	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598003777	structural tetrad; other site
99598003778	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
99598003779	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
99598003780	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
99598003781	active site clefts [active]
99598003782	zinc binding site [ion binding]; other site
99598003783	dimer interface [polypeptide binding]; other site
99598003784	Abhydrolase family; Region: Abhydrolase_7; pfam12715
99598003785	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
99598003786	DNA polymerase III subunit delta'; Validated; Region: PRK07399
99598003787	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
99598003788	DNA polymerase III subunit delta'; Validated; Region: PRK08485
99598003789	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
99598003790	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
99598003791	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
99598003792	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
99598003793	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598003794	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598003795	active site
99598003796	ATP binding site [chemical binding]; other site
99598003797	substrate binding site [chemical binding]; other site
99598003798	activation loop (A-loop); other site
99598003799	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598003800	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598003801	active site
99598003802	ATP binding site [chemical binding]; other site
99598003803	substrate binding site [chemical binding]; other site
99598003804	activation loop (A-loop); other site
99598003805	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598003806	putative active site [active]
99598003807	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
99598003808	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
99598003809	purine monophosphate binding site [chemical binding]; other site
99598003810	dimer interface [polypeptide binding]; other site
99598003811	putative catalytic residues [active]
99598003812	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
99598003813	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
99598003814	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
99598003815	Ferritin-like domain; Region: Ferritin; pfam00210
99598003816	dimanganese center [ion binding]; other site
99598003817	Predicted membrane protein [Function unknown]; Region: COG2261
99598003818	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
99598003819	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598003820	FeS/SAM binding site; other site
99598003821	HemN C-terminal domain; Region: HemN_C; pfam06969
99598003822	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
99598003823	heme binding pocket [chemical binding]; other site
99598003824	heme ligand [chemical binding]; other site
99598003825	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
99598003826	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
99598003827	tetramer interface [polypeptide binding]; other site
99598003828	active site
99598003829	Mg2+/Mn2+ binding site [ion binding]; other site
99598003830	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
99598003831	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
99598003832	active site
99598003833	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598003834	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598003835	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598003836	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598003837	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598003838	active site
99598003839	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598003840	active site
99598003841	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
99598003842	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598003843	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99598003844	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
99598003845	Walker A/P-loop; other site
99598003846	ATP binding site [chemical binding]; other site
99598003847	Q-loop/lid; other site
99598003848	ABC transporter signature motif; other site
99598003849	Walker B; other site
99598003850	D-loop; other site
99598003851	H-loop/switch region; other site
99598003852	Bacterial sugar transferase; Region: Bac_transf; cl00939
99598003853	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
99598003854	Chain length determinant protein; Region: Wzz; cl15801
99598003855	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
99598003856	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598003857	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
99598003858	putative ADP-binding pocket [chemical binding]; other site
99598003859	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
99598003860	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
99598003861	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
99598003862	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
99598003863	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
99598003864	extended (e) SDRs; Region: SDR_e; cd08946
99598003865	NAD(P) binding site [chemical binding]; other site
99598003866	active site
99598003867	substrate binding site [chemical binding]; other site
99598003868	Predicted dehydrogenase [General function prediction only]; Region: COG0579
99598003869	hydroxyglutarate oxidase; Provisional; Region: PRK11728
99598003870	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
99598003871	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
99598003872	substrate binding site; other site
99598003873	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
99598003874	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
99598003875	substrate binding site [chemical binding]; other site
99598003876	activation loop (A-loop); other site
99598003877	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598003878	binding surface
99598003879	TPR repeat; Region: TPR_11; pfam13414
99598003880	TPR motif; other site
99598003881	TPR repeat; Region: TPR_11; pfam13414
99598003882	TPR repeat; Region: TPR_11; pfam13414
99598003883	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598003884	TPR motif; other site
99598003885	TPR repeat; Region: TPR_11; pfam13414
99598003886	binding surface
99598003887	Protein phosphatase 2C; Region: PP2C_2; pfam13672
99598003888	Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain [General function prediction only]; Region: TerY; COG4245
99598003889	metal ion-dependent adhesion site (MIDAS); other site
99598003890	Response regulator receiver domain; Region: Response_reg; pfam00072
99598003891	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598003892	active site
99598003893	phosphorylation site [posttranslational modification]
99598003894	intermolecular recognition site; other site
99598003895	dimerization interface [polypeptide binding]; other site
99598003896	Response regulator receiver domain; Region: Response_reg; pfam00072
99598003897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598003898	active site
99598003899	phosphorylation site [posttranslational modification]
99598003900	intermolecular recognition site; other site
99598003901	dimerization interface [polypeptide binding]; other site
99598003902	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598003903	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
99598003904	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
99598003905	putative active site [active]
99598003906	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
99598003907	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
99598003908	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
99598003909	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
99598003910	putative tRNA-binding site [nucleotide binding]; other site
99598003911	B3/4 domain; Region: B3_4; pfam03483
99598003912	tRNA synthetase B5 domain; Region: B5; smart00874
99598003913	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
99598003914	dimer interface [polypeptide binding]; other site
99598003915	motif 1; other site
99598003916	motif 3; other site
99598003917	motif 2; other site
99598003918	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
99598003919	YciI-like protein; Reviewed; Region: PRK12864
99598003920	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
99598003921	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
99598003922	active site
99598003923	Substrate binding site; other site
99598003924	Mg++ binding site; other site
99598003925	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
99598003926	putative CoA binding site [chemical binding]; other site
99598003927	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
99598003928	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
99598003929	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
99598003930	catalytic site [active]
99598003931	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
99598003932	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
99598003933	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
99598003934	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
99598003935	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
99598003936	heme binding pocket [chemical binding]; other site
99598003937	heme ligand [chemical binding]; other site
99598003938	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
99598003939	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598003940	FeS/SAM binding site; other site
99598003941	HemN C-terminal domain; Region: HemN_C; pfam06969
99598003942	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
99598003943	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
99598003944	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598003945	FeS/SAM binding site; other site
99598003946	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
99598003947	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
99598003948	Protein of unknown function (DUF751); Region: DUF751; pfam05421
99598003949	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
99598003950	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
99598003951	hypothetical protein; Provisional; Region: PRK04194
99598003952	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
99598003953	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
99598003954	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
99598003955	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
99598003956	substrate binding site [chemical binding]; other site
99598003957	active site
99598003958	catalytic residues [active]
99598003959	heterodimer interface [polypeptide binding]; other site
99598003960	HEAT repeats; Region: HEAT_2; pfam13646
99598003961	HEAT repeats; Region: HEAT_2; pfam13646
99598003962	FOG: CBS domain [General function prediction only]; Region: COG0517
99598003963	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
99598003964	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
99598003965	active site
99598003966	8-oxo-dGMP binding site [chemical binding]; other site
99598003967	nudix motif; other site
99598003968	metal binding site [ion binding]; metal-binding site
99598003969	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598003970	dimer interface [polypeptide binding]; other site
99598003971	phosphorylation site [posttranslational modification]
99598003972	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598003973	ATP binding site [chemical binding]; other site
99598003974	Mg2+ binding site [ion binding]; other site
99598003975	G-X-G motif; other site
99598003976	Uncharacterized conserved protein [Function unknown]; Region: COG3287
99598003977	FIST N domain; Region: FIST; pfam08495
99598003978	FIST C domain; Region: FIST_C; pfam10442
99598003979	threonine synthase; Reviewed; Region: PRK06721
99598003980	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
99598003981	homodimer interface [polypeptide binding]; other site
99598003982	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598003983	catalytic residue [active]
99598003984	S-layer homology domain; Region: SLH; pfam00395
99598003985	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
99598003986	S-layer homology domain; Region: SLH; pfam00395
99598003987	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
99598003988	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598003989	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598003990	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598003991	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598003992	TrkA-C domain; Region: TrkA_C; pfam02080
99598003993	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598003994	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598003995	active site
99598003996	ATP binding site [chemical binding]; other site
99598003997	substrate binding site [chemical binding]; other site
99598003998	activation loop (A-loop); other site
99598003999	potassium-transporting ATPase subunit C; Provisional; Region: PRK14003
99598004000	F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604
99598004001	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
99598004002	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99598004003	Soluble P-type ATPase [General function prediction only]; Region: COG4087
99598004004	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
99598004005	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
99598004006	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
99598004007	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
99598004008	dimer interface [polypeptide binding]; other site
99598004009	active site
99598004010	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
99598004011	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598004012	putative active site [active]
99598004013	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598004014	GAF domain; Region: GAF; pfam01590
99598004015	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598004016	Phytochrome region; Region: PHY; pfam00360
99598004017	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598004018	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598004019	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598004020	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598004021	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598004022	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598004023	dimer interface [polypeptide binding]; other site
99598004024	phosphorylation site [posttranslational modification]
99598004025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598004026	ATP binding site [chemical binding]; other site
99598004027	Mg2+ binding site [ion binding]; other site
99598004028	G-X-G motif; other site
99598004029	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
99598004030	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
99598004031	P loop; other site
99598004032	Nucleotide binding site [chemical binding]; other site
99598004033	DTAP/Switch II; other site
99598004034	Switch I; other site
99598004035	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
99598004036	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
99598004037	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
99598004038	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
99598004039	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
99598004040	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
99598004041	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
99598004042	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598004043	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598004044	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
99598004045	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598004046	putative active site [active]
99598004047	heme pocket [chemical binding]; other site
99598004048	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598004049	dimer interface [polypeptide binding]; other site
99598004050	phosphorylation site [posttranslational modification]
99598004051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598004052	ATP binding site [chemical binding]; other site
99598004053	Mg2+ binding site [ion binding]; other site
99598004054	G-X-G motif; other site
99598004055	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
99598004056	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
99598004057	cobalamin binding residues [chemical binding]; other site
99598004058	putative BtuC binding residues; other site
99598004059	dimer interface [polypeptide binding]; other site
99598004060	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
99598004061	ABC1 family; Region: ABC1; pfam03109
99598004062	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
99598004063	active site
99598004064	ATP binding site [chemical binding]; other site
99598004065	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
99598004066	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
99598004067	Walker A/P-loop; other site
99598004068	ATP binding site [chemical binding]; other site
99598004069	Q-loop/lid; other site
99598004070	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
99598004071	ABC transporter signature motif; other site
99598004072	Walker B; other site
99598004073	D-loop; other site
99598004074	H-loop/switch region; other site
99598004075	PAS fold; Region: PAS_4; pfam08448
99598004076	GAF domain; Region: GAF_3; pfam13492
99598004077	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598004078	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598004079	dimer interface [polypeptide binding]; other site
99598004080	phosphorylation site [posttranslational modification]
99598004081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598004082	ATP binding site [chemical binding]; other site
99598004083	Mg2+ binding site [ion binding]; other site
99598004084	G-X-G motif; other site
99598004085	Response regulator receiver domain; Region: Response_reg; pfam00072
99598004086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598004087	active site
99598004088	phosphorylation site [posttranslational modification]
99598004089	intermolecular recognition site; other site
99598004090	dimerization interface [polypeptide binding]; other site
99598004091	PAS fold; Region: PAS_4; pfam08448
99598004092	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598004093	putative active site [active]
99598004094	heme pocket [chemical binding]; other site
99598004095	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598004096	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598004097	dimer interface [polypeptide binding]; other site
99598004098	phosphorylation site [posttranslational modification]
99598004099	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598004100	ATP binding site [chemical binding]; other site
99598004101	Mg2+ binding site [ion binding]; other site
99598004102	G-X-G motif; other site
99598004103	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598004104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598004105	active site
99598004106	phosphorylation site [posttranslational modification]
99598004107	intermolecular recognition site; other site
99598004108	dimerization interface [polypeptide binding]; other site
99598004109	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
99598004110	active site
99598004111	dimerization interface [polypeptide binding]; other site
99598004112	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
99598004113	metal coordination site [ion binding]; other site
99598004114	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
99598004115	metal coordination site [ion binding]; other site
99598004116	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
99598004117	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598004118	dimerization interface [polypeptide binding]; other site
99598004119	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
99598004120	cyclase homology domain; Region: CHD; cd07302
99598004121	nucleotidyl binding site; other site
99598004122	metal binding site [ion binding]; metal-binding site
99598004123	dimer interface [polypeptide binding]; other site
99598004124	XisI protein; Region: XisI; pfam08869
99598004125	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
99598004126	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
99598004127	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
99598004128	replicative DNA helicase; Region: DnaB; TIGR00665
99598004129	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
99598004130	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
99598004131	Walker A motif; other site
99598004132	ATP binding site [chemical binding]; other site
99598004133	Walker B motif; other site
99598004134	DNA binding loops [nucleotide binding]
99598004135	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
99598004136	active site
99598004137	catalytic triad [active]
99598004138	YGGT family; Region: YGGT; pfam02325
99598004139	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99598004140	active site
99598004141	carotene isomerase; Region: carot_isom; TIGR02730
99598004142	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99598004143	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
99598004144	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
99598004145	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
99598004146	Transposase; Region: DEDD_Tnp_IS110; pfam01548
99598004147	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
99598004148	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
99598004149	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
99598004150	intersubunit interface [polypeptide binding]; other site
99598004151	ATP-grasp domain; Region: ATP-grasp; pfam02222
99598004152	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598004153	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
99598004154	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598004155	oligomeric interface; other site
99598004156	putative active site [active]
99598004157	homodimer interface [polypeptide binding]; other site
99598004158	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
99598004159	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598004160	Walker A/P-loop; other site
99598004161	ATP binding site [chemical binding]; other site
99598004162	Q-loop/lid; other site
99598004163	ABC transporter signature motif; other site
99598004164	Walker B; other site
99598004165	D-loop; other site
99598004166	H-loop/switch region; other site
99598004167	ABC transporter; Region: ABC_tran_2; pfam12848
99598004168	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
99598004169	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
99598004170	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
99598004171	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
99598004172	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
99598004173	Cytochrome P450; Region: p450; pfam00067
99598004174	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
99598004175	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
99598004176	P-loop; other site
99598004177	Magnesium ion binding site [ion binding]; other site
99598004178	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
99598004179	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
99598004180	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
99598004181	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
99598004182	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
99598004183	Peptidase family M23; Region: Peptidase_M23; pfam01551
99598004184	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
99598004185	Lumazine binding domain; Region: Lum_binding; pfam00677
99598004186	Lumazine binding domain; Region: Lum_binding; pfam00677
99598004187	Bifunctional nuclease; Region: DNase-RNase; pfam02577
99598004188	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598004189	putative active site [active]
99598004190	Methyltransferase domain; Region: Methyltransf_31; pfam13847
99598004191	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598004192	S-adenosylmethionine binding site [chemical binding]; other site
99598004193	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
99598004194	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
99598004195	Peptidase family U32; Region: Peptidase_U32; pfam01136
99598004196	Collagenase; Region: DUF3656; pfam12392
99598004197	Peptidase family U32; Region: Peptidase_U32; cl03113
99598004198	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99598004199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598004200	active site
99598004201	phosphorylation site [posttranslational modification]
99598004202	intermolecular recognition site; other site
99598004203	dimerization interface [polypeptide binding]; other site
99598004204	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99598004205	DNA binding site [nucleotide binding]
99598004206	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
99598004207	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598004208	dimer interface [polypeptide binding]; other site
99598004209	phosphorylation site [posttranslational modification]
99598004210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598004211	ATP binding site [chemical binding]; other site
99598004212	Mg2+ binding site [ion binding]; other site
99598004213	G-X-G motif; other site
99598004214	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
99598004215	PhoU domain; Region: PhoU; pfam01895
99598004216	PhoU domain; Region: PhoU; pfam01895
99598004217	Competence protein CoiA-like family; Region: CoiA; cl11541
99598004218	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99598004219	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598004220	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598004221	Walker A/P-loop; other site
99598004222	ATP binding site [chemical binding]; other site
99598004223	Q-loop/lid; other site
99598004224	ABC transporter signature motif; other site
99598004225	Walker B; other site
99598004226	D-loop; other site
99598004227	H-loop/switch region; other site
99598004228	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
99598004229	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
99598004230	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
99598004231	G1 box; other site
99598004232	GTP/Mg2+ binding site [chemical binding]; other site
99598004233	G2 box; other site
99598004234	Switch I region; other site
99598004235	G3 box; other site
99598004236	Switch II region; other site
99598004237	G4 box; other site
99598004238	G5 box; other site
99598004239	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
99598004240	G1 box; other site
99598004241	GTP/Mg2+ binding site [chemical binding]; other site
99598004242	G2 box; other site
99598004243	Switch I region; other site
99598004244	G3 box; other site
99598004245	Switch II region; other site
99598004246	G4 box; other site
99598004247	G5 box; other site
99598004248	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
99598004249	V4R domain; Region: V4R; cl15268
99598004250	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
99598004251	putative active site [active]
99598004252	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
99598004253	PhoH-like protein; Region: PhoH; pfam02562
99598004254	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
99598004255	KH domain; Region: KH_4; pfam13083
99598004256	G-X-X-G motif; other site
99598004257	ribosomal protein S16; Region: rps16; CHL00005
99598004258	signal recognition particle protein; Provisional; Region: PRK10867
99598004259	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
99598004260	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
99598004261	GTP binding site [chemical binding]; other site
99598004262	Signal peptide binding domain; Region: SRP_SPB; pfam02978
99598004263	Uncharacterized conserved protein [Function unknown]; Region: COG5464
99598004264	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
99598004265	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
99598004266	Transposase IS200 like; Region: Y1_Tnp; cl00848
99598004267	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
99598004268	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
99598004269	Protein of unknown function, DUF608; Region: DUF608; pfam04685
99598004270	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
99598004271	ligand binding site [chemical binding]; other site
99598004272	flexible hinge region; other site
99598004273	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
99598004274	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
99598004275	putative active site [active]
99598004276	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598004277	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598004278	Walker A/P-loop; other site
99598004279	ATP binding site [chemical binding]; other site
99598004280	Q-loop/lid; other site
99598004281	ABC transporter signature motif; other site
99598004282	Walker B; other site
99598004283	D-loop; other site
99598004284	H-loop/switch region; other site
99598004285	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
99598004286	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
99598004287	Homeodomain-like domain; Region: HTH_23; pfam13384
99598004288	Winged helix-turn helix; Region: HTH_29; pfam13551
99598004289	Winged helix-turn helix; Region: HTH_33; pfam13592
99598004290	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598004291	ligand binding site [chemical binding]; other site
99598004292	flexible hinge region; other site
99598004293	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
99598004294	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
99598004295	putative active site [active]
99598004296	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598004297	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598004298	Walker A/P-loop; other site
99598004299	ATP binding site [chemical binding]; other site
99598004300	Q-loop/lid; other site
99598004301	ABC transporter signature motif; other site
99598004302	Walker B; other site
99598004303	D-loop; other site
99598004304	H-loop/switch region; other site
99598004305	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
99598004306	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99598004307	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598004308	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
99598004309	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
99598004310	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
99598004311	Phosphotransferase enzyme family; Region: APH; pfam01636
99598004312	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
99598004313	substrate binding site [chemical binding]; other site
99598004314	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
99598004315	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
99598004316	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
99598004317	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
99598004318	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
99598004319	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
99598004320	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99598004321	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99598004322	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
99598004323	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598004324	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598004325	dimer interface [polypeptide binding]; other site
99598004326	phosphorylation site [posttranslational modification]
99598004327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598004328	ATP binding site [chemical binding]; other site
99598004329	Mg2+ binding site [ion binding]; other site
99598004330	G-X-G motif; other site
99598004331	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
99598004332	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
99598004333	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
99598004334	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
99598004335	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
99598004336	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
99598004337	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
99598004338	catalytic residues [active]
99598004339	PetN; Region: PetN; pfam03742
99598004340	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
99598004341	active site
99598004342	catalytic site [active]
99598004343	substrate binding site [chemical binding]; other site
99598004344	Membrane protein involved in colicin uptake [Cell envelope biogenesis, outer membrane]; Region: TolA; COG3064
99598004345	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
99598004346	GSH binding site [chemical binding]; other site
99598004347	catalytic residues [active]
99598004348	glutathione synthetase; Provisional; Region: PRK05246
99598004349	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
99598004350	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
99598004351	cell division protein FtsZ; Validated; Region: PRK09330
99598004352	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
99598004353	nucleotide binding site [chemical binding]; other site
99598004354	SulA interaction site; other site
99598004355	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
99598004356	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
99598004357	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
99598004358	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
99598004359	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598004360	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598004361	structural tetrad; other site
99598004362	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598004363	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598004364	structural tetrad; other site
99598004365	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598004366	structural tetrad; other site
99598004367	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598004368	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716
99598004369	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
99598004370	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99598004371	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
99598004372	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99598004373	DNA binding residues [nucleotide binding]
99598004374	photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877
99598004375	PsbJ; Region: PsbJ; pfam01788
99598004376	photosystem II reaction center L; Provisional; Region: psbL; PRK00753
99598004377	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
99598004378	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
99598004379	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
99598004380	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
99598004381	Ycf48-like protein; Provisional; Region: PRK13684
99598004382	Rubredoxin [Energy production and conversion]; Region: COG1773
99598004383	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
99598004384	iron binding site [ion binding]; other site
99598004385	NADH dehydrogenase subunit 3; Region: ndhC; CHL00022
99598004386	NADH dehydrogenase subunit K; Region: ndhK; CHL00023
99598004387	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
99598004388	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
99598004389	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598004390	putative active site [active]
99598004391	Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628
99598004392	5' RNA guide strand anchoring site; other site
99598004393	active site
99598004394	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
99598004395	anthranilate synthase component I; Provisional; Region: PRK13565
99598004396	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
99598004397	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
99598004398	PsaD; Region: PsaD; pfam02531
99598004399	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
99598004400	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
99598004401	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598004402	GAF domain; Region: GAF; pfam01590
99598004403	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598004404	dimer interface [polypeptide binding]; other site
99598004405	phosphorylation site [posttranslational modification]
99598004406	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598004407	ATP binding site [chemical binding]; other site
99598004408	Mg2+ binding site [ion binding]; other site
99598004409	G-X-G motif; other site
99598004410	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
99598004411	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
99598004412	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99598004413	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99598004414	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
99598004415	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
99598004416	C-terminal domain interface [polypeptide binding]; other site
99598004417	GSH binding site (G-site) [chemical binding]; other site
99598004418	dimer interface [polypeptide binding]; other site
99598004419	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
99598004420	N-terminal domain interface [polypeptide binding]; other site
99598004421	dimer interface [polypeptide binding]; other site
99598004422	substrate binding pocket (H-site) [chemical binding]; other site
99598004423	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
99598004424	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
99598004425	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
99598004426	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
99598004427	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
99598004428	active site
99598004429	dimer interface [polypeptide binding]; other site
99598004430	motif 1; other site
99598004431	motif 2; other site
99598004432	motif 3; other site
99598004433	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
99598004434	anticodon binding site; other site
99598004435	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
99598004436	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
99598004437	homoserine kinase; Provisional; Region: PRK01212
99598004438	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
99598004439	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
99598004440	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
99598004441	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
99598004442	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
99598004443	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
99598004444	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
99598004445	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
99598004446	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
99598004447	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
99598004448	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
99598004449	active site
99598004450	metal binding site [ion binding]; metal-binding site
99598004451	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
99598004452	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
99598004453	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
99598004454	trimer interface [polypeptide binding]; other site
99598004455	putative metal binding site [ion binding]; other site
99598004456	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
99598004457	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
99598004458	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
99598004459	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
99598004460	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
99598004461	Cell division protein FtsA; Region: FtsA; cl17206
99598004462	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
99598004463	basic region leucin zipper; Region: BRLZ; smart00338
99598004464	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
99598004465	AMIN domain; Region: AMIN; pfam11741
99598004466	Secretin and TonB N terminus short domain; Region: STN; pfam07660
99598004467	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
99598004468	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
99598004469	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
99598004470	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
99598004471	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
99598004472	Probable transposase; Region: OrfB_IS605; pfam01385
99598004473	Transposase IS200 like; Region: Y1_Tnp; pfam01797
99598004474	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
99598004475	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
99598004476	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
99598004477	DNA binding site [nucleotide binding]
99598004478	catalytic residue [active]
99598004479	H2TH interface [polypeptide binding]; other site
99598004480	putative catalytic residues [active]
99598004481	turnover-facilitating residue; other site
99598004482	intercalation triad [nucleotide binding]; other site
99598004483	8OG recognition residue [nucleotide binding]; other site
99598004484	putative reading head residues; other site
99598004485	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
99598004486	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
99598004487	photosystem I reaction center subunit IV; Provisional; Region: PRK02749
99598004488	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
99598004489	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
99598004490	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
99598004491	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
99598004492	Mg++ binding site [ion binding]; other site
99598004493	putative catalytic motif [active]
99598004494	putative substrate binding site [chemical binding]; other site
99598004495	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
99598004496	MPT binding site; other site
99598004497	trimer interface [polypeptide binding]; other site
99598004498	photosystem II reaction center protein Psb28; Provisional; Region: PRK13612
99598004499	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
99598004500	putative active site [active]
99598004501	dimerization interface [polypeptide binding]; other site
99598004502	putative tRNAtyr binding site [nucleotide binding]; other site
99598004503	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
99598004504	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99598004505	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
99598004506	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
99598004507	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
99598004508	active site
99598004509	HIGH motif; other site
99598004510	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
99598004511	KMSKS motif; other site
99598004512	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
99598004513	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
99598004514	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
99598004515	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
99598004516	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
99598004517	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575
99598004518	DNA gyrase subunit A; Validated; Region: PRK05560
99598004519	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
99598004520	CAP-like domain; other site
99598004521	active site
99598004522	primary dimer interface [polypeptide binding]; other site
99598004523	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99598004524	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99598004525	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99598004526	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99598004527	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99598004528	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99598004529	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
99598004530	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
99598004531	putative active site [active]
99598004532	catalytic triad [active]
99598004533	putative dimer interface [polypeptide binding]; other site
99598004534	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
99598004535	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598004536	Walker A/P-loop; other site
99598004537	ATP binding site [chemical binding]; other site
99598004538	Q-loop/lid; other site
99598004539	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598004540	ABC transporter signature motif; other site
99598004541	Walker B; other site
99598004542	D-loop; other site
99598004543	H-loop/switch region; other site
99598004544	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
99598004545	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
99598004546	active site
99598004547	metal binding site [ion binding]; metal-binding site
99598004548	DNA binding site [nucleotide binding]
99598004549	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
99598004550	HerA helicase [Replication, recombination, and repair]; Region: COG0433
99598004551	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380
99598004552	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
99598004553	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
99598004554	active site
99598004555	Zn binding site [ion binding]; other site
99598004556	tellurite resistance protein terB; Region: terB; cd07176
99598004557	putative metal binding site [ion binding]; other site
99598004558	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
99598004559	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
99598004560	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
99598004561	active site residue [active]
99598004562	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
99598004563	active site residue [active]
99598004564	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598004565	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99598004566	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598004567	DNA binding residues [nucleotide binding]
99598004568	dimerization interface [polypeptide binding]; other site
99598004569	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
99598004570	TIGR03032 family protein; Region: TIGR03032
99598004571	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598004572	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
99598004573	Coenzyme A binding pocket [chemical binding]; other site
99598004574	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598004575	binding surface
99598004576	TPR motif; other site
99598004577	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
99598004578	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598004579	binding surface
99598004580	TPR motif; other site
99598004581	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598004582	binding surface
99598004583	TPR motif; other site
99598004584	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598004585	Family description; Region: VCBS; pfam13517
99598004586	Family description; Region: VCBS; pfam13517
99598004587	VCBS repeat; Region: VCBS_repeat; TIGR01965
99598004588	VCBS repeat; Region: VCBS_repeat; TIGR01965
99598004589	VCBS repeat; Region: VCBS_repeat; TIGR01965
99598004590	VCBS repeat; Region: VCBS_repeat; TIGR01965
99598004591	VCBS repeat; Region: VCBS_repeat; TIGR01965
99598004592	VCBS repeat; Region: VCBS_repeat; TIGR01965
99598004593	VCBS repeat; Region: VCBS_repeat; TIGR01965
99598004594	VCBS repeat; Region: VCBS_repeat; TIGR01965
99598004595	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
99598004596	VCBS repeat; Region: VCBS_repeat; TIGR01965
99598004597	VCBS repeat; Region: VCBS_repeat; TIGR01965
99598004598	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598004599	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598004600	dimerization interface [polypeptide binding]; other site
99598004601	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598004602	dimer interface [polypeptide binding]; other site
99598004603	phosphorylation site [posttranslational modification]
99598004604	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598004605	ATP binding site [chemical binding]; other site
99598004606	Mg2+ binding site [ion binding]; other site
99598004607	G-X-G motif; other site
99598004608	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99598004609	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598004610	active site
99598004611	phosphorylation site [posttranslational modification]
99598004612	intermolecular recognition site; other site
99598004613	dimerization interface [polypeptide binding]; other site
99598004614	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99598004615	DNA binding site [nucleotide binding]
99598004616	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
99598004617	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99598004618	active site
99598004619	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
99598004620	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598004621	putative substrate translocation pore; other site
99598004622	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598004623	putative active site [active]
99598004624	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
99598004625	Clp amino terminal domain; Region: Clp_N; pfam02861
99598004626	Clp amino terminal domain; Region: Clp_N; pfam02861
99598004627	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598004628	Walker A motif; other site
99598004629	ATP binding site [chemical binding]; other site
99598004630	Walker B motif; other site
99598004631	arginine finger; other site
99598004632	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598004633	Walker A motif; other site
99598004634	ATP binding site [chemical binding]; other site
99598004635	Walker B motif; other site
99598004636	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
99598004637	Predicted membrane protein [Function unknown]; Region: COG3431
99598004638	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598004639	binding surface
99598004640	TPR motif; other site
99598004641	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598004642	binding surface
99598004643	TPR repeat; Region: TPR_11; pfam13414
99598004644	TPR motif; other site
99598004645	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598004646	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
99598004647	elongation factor G; Reviewed; Region: PRK12740
99598004648	G1 box; other site
99598004649	putative GEF interaction site [polypeptide binding]; other site
99598004650	GTP/Mg2+ binding site [chemical binding]; other site
99598004651	Switch I region; other site
99598004652	G2 box; other site
99598004653	G3 box; other site
99598004654	Switch II region; other site
99598004655	G4 box; other site
99598004656	G5 box; other site
99598004657	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
99598004658	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
99598004659	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
99598004660	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
99598004661	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_1; cd03400
99598004662	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
99598004663	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
99598004664	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
99598004665	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
99598004666	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
99598004667	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
99598004668	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
99598004669	protein binding site [polypeptide binding]; other site
99598004670	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
99598004671	Catalytic dyad [active]
99598004672	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
99598004673	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
99598004674	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
99598004675	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
99598004676	catalytic triad [active]
99598004677	conserved cis-peptide bond; other site
99598004678	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
99598004679	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
99598004680	Peptidase family M23; Region: Peptidase_M23; pfam01551
99598004681	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
99598004682	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
99598004683	protein binding site [polypeptide binding]; other site
99598004684	Protein of unknown function (DUF760); Region: DUF760; pfam05542
99598004685	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
99598004686	Transcriptional regulators [Transcription]; Region: MarR; COG1846
99598004687	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
99598004688	substrate binding site; other site
99598004689	dimer interface; other site
99598004690	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
99598004691	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
99598004692	putative active site [active]
99598004693	Domain of unknown function (DUF1817); Region: DUF1817; pfam08847
99598004694	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
99598004695	metal binding site 2 [ion binding]; metal-binding site
99598004696	putative DNA binding helix; other site
99598004697	metal binding site 1 [ion binding]; metal-binding site
99598004698	dimer interface [polypeptide binding]; other site
99598004699	structural Zn2+ binding site [ion binding]; other site
99598004700	Response regulator receiver domain; Region: Response_reg; pfam00072
99598004701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598004702	active site
99598004703	phosphorylation site [posttranslational modification]
99598004704	intermolecular recognition site; other site
99598004705	dimerization interface [polypeptide binding]; other site
99598004706	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
99598004707	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
99598004708	topology modulation protein; Reviewed; Region: PRK08118
99598004709	AAA domain; Region: AAA_17; pfam13207
99598004710	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
99598004711	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
99598004712	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
99598004713	protein binding surface [polypeptide binding]; other site
99598004714	NACHT domain; Region: NACHT; pfam05729
99598004715	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
99598004716	putative active site [active]
99598004717	homotetrameric interface [polypeptide binding]; other site
99598004718	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
99598004719	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
99598004720	putative homodimer interface [polypeptide binding]; other site
99598004721	putative active site pocket [active]
99598004722	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
99598004723	photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655
99598004724	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
99598004725	OstA-like protein; Region: OstA; cl00844
99598004726	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
99598004727	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598004728	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598004729	active site
99598004730	phosphorylation site [posttranslational modification]
99598004731	intermolecular recognition site; other site
99598004732	dimerization interface [polypeptide binding]; other site
99598004733	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
99598004734	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598004735	putative active site [active]
99598004736	heme pocket [chemical binding]; other site
99598004737	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598004738	dimer interface [polypeptide binding]; other site
99598004739	phosphorylation site [posttranslational modification]
99598004740	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598004741	ATP binding site [chemical binding]; other site
99598004742	Mg2+ binding site [ion binding]; other site
99598004743	G-X-G motif; other site
99598004744	GAF domain; Region: GAF; pfam01590
99598004745	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598004746	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598004747	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598004748	putative active site [active]
99598004749	heme pocket [chemical binding]; other site
99598004750	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598004751	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598004752	putative active site [active]
99598004753	heme pocket [chemical binding]; other site
99598004754	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598004755	putative active site [active]
99598004756	heme pocket [chemical binding]; other site
99598004757	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598004758	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598004759	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
99598004760	Histidine kinase; Region: HisKA_2; pfam07568
99598004761	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598004762	ATP binding site [chemical binding]; other site
99598004763	Mg2+ binding site [ion binding]; other site
99598004764	G-X-G motif; other site
99598004765	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
99598004766	NADPH bind site [chemical binding]; other site
99598004767	putative FMN binding site [chemical binding]; other site
99598004768	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
99598004769	putative FMN binding site [chemical binding]; other site
99598004770	NADPH bind site [chemical binding]; other site
99598004771	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
99598004772	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99598004773	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
99598004774	active site
99598004775	catalytic tetrad [active]
99598004776	ketol-acid reductoisomerase; Provisional; Region: PRK05479
99598004777	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
99598004778	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
99598004779	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
99598004780	CARDB; Region: CARDB; pfam07705
99598004781	CARDB; Region: CARDB; pfam07705
99598004782	CARDB; Region: CARDB; pfam07705
99598004783	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
99598004784	Amidase; Region: Amidase; pfam01425
99598004785	methionine aminopeptidase; Provisional; Region: PRK08671
99598004786	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
99598004787	active site
99598004788	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
99598004789	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
99598004790	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598004791	substrate binding pocket [chemical binding]; other site
99598004792	membrane-bound complex binding site; other site
99598004793	hinge residues; other site
99598004794	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
99598004795	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
99598004796	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598004797	putative active site [active]
99598004798	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
99598004799	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
99598004800	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
99598004801	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
99598004802	N-acetyl-D-glucosamine binding site [chemical binding]; other site
99598004803	catalytic residue [active]
99598004804	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
99598004805	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
99598004806	dimer interface [polypeptide binding]; other site
99598004807	putative tRNA-binding site [nucleotide binding]; other site
99598004808	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
99598004809	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
99598004810	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
99598004811	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
99598004812	cytochrome b subunit interaction site [polypeptide binding]; other site
99598004813	[2Fe-2S] cluster binding site [ion binding]; other site
99598004814	cytochrome f; Region: petA; CHL00037
99598004815	apocytochrome f; Reviewed; Region: PRK02693
99598004816	Uncharacterized conserved protein [Function unknown]; Region: COG1543
99598004817	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
99598004818	active site
99598004819	substrate binding site [chemical binding]; other site
99598004820	catalytic site [active]
99598004821	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
99598004822	Uncharacterized conserved protein [Function unknown]; Region: COG5464
99598004823	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
99598004824	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598004825	putative active site [active]
99598004826	GTPase RsgA; Reviewed; Region: PRK12289
99598004827	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
99598004828	RNA binding site [nucleotide binding]; other site
99598004829	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
99598004830	GTPase/Zn-binding domain interface [polypeptide binding]; other site
99598004831	GTP/Mg2+ binding site [chemical binding]; other site
99598004832	G4 box; other site
99598004833	G5 box; other site
99598004834	G1 box; other site
99598004835	Switch I region; other site
99598004836	G2 box; other site
99598004837	G3 box; other site
99598004838	Switch II region; other site
99598004839	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
99598004840	CPxP  motif; other site
99598004841	chaperone protein DnaJ; Provisional; Region: PRK14293
99598004842	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99598004843	HSP70 interaction site [polypeptide binding]; other site
99598004844	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
99598004845	Zn binding sites [ion binding]; other site
99598004846	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
99598004847	dimer interface [polypeptide binding]; other site
99598004848	molecular chaperone DnaK; Provisional; Region: PRK13411
99598004849	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
99598004850	nucleotide binding site [chemical binding]; other site
99598004851	NEF interaction site [polypeptide binding]; other site
99598004852	SBD interface [polypeptide binding]; other site
99598004853	GrpE; Region: GrpE; pfam01025
99598004854	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
99598004855	dimer interface [polypeptide binding]; other site
99598004856	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
99598004857	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
99598004858	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
99598004859	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
99598004860	Walker A motif; other site
99598004861	ATP binding site [chemical binding]; other site
99598004862	Walker B motif; other site
99598004863	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
99598004864	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
99598004865	Walker A motif; other site
99598004866	ATP binding site [chemical binding]; other site
99598004867	Walker B motif; other site
99598004868	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
99598004869	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
99598004870	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
99598004871	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
99598004872	tetramer (dimer of dimers) interface [polypeptide binding]; other site
99598004873	active site
99598004874	dimer interface [polypeptide binding]; other site
99598004875	S-layer homology domain; Region: SLH; pfam00395
99598004876	S-layer homology domain; Region: SLH; pfam00395
99598004877	S-layer homology domain; Region: SLH; pfam00395
99598004878	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
99598004879	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
99598004880	TPP-binding site; other site
99598004881	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
99598004882	PYR/PP interface [polypeptide binding]; other site
99598004883	dimer interface [polypeptide binding]; other site
99598004884	TPP binding site [chemical binding]; other site
99598004885	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
99598004886	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598004887	putative active site [active]
99598004888	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598004889	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598004890	active site
99598004891	ATP binding site [chemical binding]; other site
99598004892	substrate binding site [chemical binding]; other site
99598004893	activation loop (A-loop); other site
99598004894	YARHG domain; Region: YARHG; pfam13308
99598004895	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598004896	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598004897	active site
99598004898	ATP binding site [chemical binding]; other site
99598004899	substrate binding site [chemical binding]; other site
99598004900	activation loop (A-loop); other site
99598004901	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
99598004902	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
99598004903	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598004904	oligomeric interface; other site
99598004905	putative active site [active]
99598004906	homodimer interface [polypeptide binding]; other site
99598004907	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
99598004908	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
99598004909	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
99598004910	putative sugar binding sites [chemical binding]; other site
99598004911	Q-X-W motif; other site
99598004912	AAA ATPase domain; Region: AAA_16; pfam13191
99598004913	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598004914	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598004915	structural tetrad; other site
99598004916	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598004917	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598004918	structural tetrad; other site
99598004919	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
99598004920	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598004921	active site
99598004922	ATP binding site [chemical binding]; other site
99598004923	substrate binding site [chemical binding]; other site
99598004924	activation loop (A-loop); other site
99598004925	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598004926	putative active site [active]
99598004927	Transposase IS200 like; Region: Y1_Tnp; pfam01797
99598004928	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
99598004929	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
99598004930	Probable transposase; Region: OrfB_IS605; pfam01385
99598004931	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
99598004932	L11 interface [polypeptide binding]; other site
99598004933	putative EF-Tu interaction site [polypeptide binding]; other site
99598004934	putative EF-G interaction site [polypeptide binding]; other site
99598004935	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
99598004936	23S rRNA interface [nucleotide binding]; other site
99598004937	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
99598004938	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
99598004939	mRNA/rRNA interface [nucleotide binding]; other site
99598004940	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
99598004941	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
99598004942	23S rRNA interface [nucleotide binding]; other site
99598004943	L7/L12 interface [polypeptide binding]; other site
99598004944	putative thiostrepton binding site; other site
99598004945	L25 interface [polypeptide binding]; other site
99598004946	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
99598004947	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
99598004948	putative homodimer interface [polypeptide binding]; other site
99598004949	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
99598004950	heterodimer interface [polypeptide binding]; other site
99598004951	homodimer interface [polypeptide binding]; other site
99598004952	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
99598004953	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
99598004954	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
99598004955	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598004956	active site
99598004957	XisH protein; Region: XisH; pfam08814
99598004958	XisI protein; Region: XisI; pfam08869
99598004959	Uncharacterized conserved protein [Function unknown]; Region: COG5607
99598004960	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
99598004961	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
99598004962	4Fe-4S binding domain; Region: Fer4; pfam00037
99598004963	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
99598004964	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
99598004965	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
99598004966	catalytic residues [active]
99598004967	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598004968	oligomeric interface; other site
99598004969	putative active site [active]
99598004970	homodimer interface [polypeptide binding]; other site
99598004971	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
99598004972	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598004973	motif II; other site
99598004974	30S ribosomal protein S1; Reviewed; Region: PRK07400
99598004975	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
99598004976	RNA binding site [nucleotide binding]; other site
99598004977	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
99598004978	RNA binding site [nucleotide binding]; other site
99598004979	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
99598004980	RNA binding site [nucleotide binding]; other site
99598004981	photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875
99598004982	photosystem II 47 kDa protein; Region: psbB; CHL00062
99598004983	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
99598004984	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
99598004985	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
99598004986	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598004987	dimer interface [polypeptide binding]; other site
99598004988	conserved gate region; other site
99598004989	putative PBP binding loops; other site
99598004990	ABC-ATPase subunit interface; other site
99598004991	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
99598004992	TPR repeat; Region: TPR_11; pfam13414
99598004993	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598004994	binding surface
99598004995	TPR motif; other site
99598004996	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598004997	TPR repeat; Region: TPR_11; pfam13414
99598004998	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598004999	binding surface
99598005000	TPR motif; other site
99598005001	TPR repeat; Region: TPR_11; pfam13414
99598005002	KTSC domain; Region: KTSC; pfam13619
99598005003	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
99598005004	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
99598005005	tRNA; other site
99598005006	putative tRNA binding site [nucleotide binding]; other site
99598005007	putative NADP binding site [chemical binding]; other site
99598005008	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
99598005009	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
99598005010	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
99598005011	putative active site [active]
99598005012	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
99598005013	GSH binding site [chemical binding]; other site
99598005014	catalytic residues [active]
99598005015	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
99598005016	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
99598005017	NAD(P) binding site [chemical binding]; other site
99598005018	Methyltransferase domain; Region: Methyltransf_23; pfam13489
99598005019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598005020	S-adenosylmethionine binding site [chemical binding]; other site
99598005021	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
99598005022	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
99598005023	DNA polymerase I; Provisional; Region: PRK05755
99598005024	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
99598005025	active site
99598005026	metal binding site 1 [ion binding]; metal-binding site
99598005027	putative 5' ssDNA interaction site; other site
99598005028	metal binding site 3; metal-binding site
99598005029	metal binding site 2 [ion binding]; metal-binding site
99598005030	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
99598005031	putative DNA binding site [nucleotide binding]; other site
99598005032	putative metal binding site [ion binding]; other site
99598005033	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
99598005034	active site
99598005035	catalytic site [active]
99598005036	substrate binding site [chemical binding]; other site
99598005037	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
99598005038	active site
99598005039	DNA binding site [nucleotide binding]
99598005040	catalytic site [active]
99598005041	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
99598005042	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598005043	active site
99598005044	motif I; other site
99598005045	motif II; other site
99598005046	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
99598005047	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
99598005048	DALR anticodon binding domain; Region: DALR_1; smart00836
99598005049	anticodon binding site; other site
99598005050	tRNA binding surface [nucleotide binding]; other site
99598005051	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598005052	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
99598005053	putative switch regulator; other site
99598005054	non-specific DNA interactions [nucleotide binding]; other site
99598005055	DNA binding site [nucleotide binding]
99598005056	sequence specific DNA binding site [nucleotide binding]; other site
99598005057	putative cAMP binding site [chemical binding]; other site
99598005058	PBP superfamily domain; Region: PBP_like_2; cl17296
99598005059	PBP superfamily domain; Region: PBP_like_2; cl17296
99598005060	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598005061	active site
99598005062	ATP binding site [chemical binding]; other site
99598005063	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598005064	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
99598005065	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99598005066	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
99598005067	putative dimerization interface [polypeptide binding]; other site
99598005068	Predicted membrane protein [Function unknown]; Region: COG4094
99598005069	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
99598005070	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
99598005071	catalytic residues [active]
99598005072	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
99598005073	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
99598005074	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
99598005075	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
99598005076	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
99598005077	toxin interface [polypeptide binding]; other site
99598005078	Zn binding site [ion binding]; other site
99598005079	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
99598005080	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
99598005081	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598005082	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
99598005083	Protein of unknown function (DUF497); Region: DUF497; pfam04365
99598005084	Restriction endonuclease; Region: Mrr_cat; pfam04471
99598005085	Predicted transcriptional regulator [Transcription]; Region: COG3905
99598005086	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
99598005087	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
99598005088	active site
99598005089	substrate binding site [chemical binding]; other site
99598005090	metal binding site [ion binding]; metal-binding site
99598005091	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
99598005092	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598005093	substrate binding pocket [chemical binding]; other site
99598005094	membrane-bound complex binding site; other site
99598005095	hinge residues; other site
99598005096	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
99598005097	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
99598005098	Walker A/P-loop; other site
99598005099	ATP binding site [chemical binding]; other site
99598005100	Q-loop/lid; other site
99598005101	ABC transporter signature motif; other site
99598005102	Walker B; other site
99598005103	D-loop; other site
99598005104	H-loop/switch region; other site
99598005105	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
99598005106	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598005107	putative active site [active]
99598005108	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
99598005109	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598005110	active site
99598005111	ATP binding site [chemical binding]; other site
99598005112	substrate binding site [chemical binding]; other site
99598005113	activation loop (A-loop); other site
99598005114	AAA domain; Region: AAA_26; pfam13500
99598005115	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
99598005116	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
99598005117	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
99598005118	metal binding site [ion binding]; metal-binding site
99598005119	dimer interface [polypeptide binding]; other site
99598005120	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
99598005121	dimer interface [polypeptide binding]; other site
99598005122	[2Fe-2S] cluster binding site [ion binding]; other site
99598005123	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
99598005124	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
99598005125	dimerization interface [polypeptide binding]; other site
99598005126	DPS ferroxidase diiron center [ion binding]; other site
99598005127	ion pore; other site
99598005128	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
99598005129	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
99598005130	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
99598005131	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
99598005132	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
99598005133	ATP-grasp domain; Region: ATP-grasp_4; cl17255
99598005134	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
99598005135	IMP binding site; other site
99598005136	dimer interface [polypeptide binding]; other site
99598005137	interdomain contacts; other site
99598005138	partial ornithine binding site; other site
99598005139	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
99598005140	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
99598005141	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99598005142	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
99598005143	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99598005144	DNA binding residues [nucleotide binding]
99598005145	Protein of unknown function (DUF760); Region: DUF760; pfam05542
99598005146	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
99598005147	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
99598005148	Walker A/P-loop; other site
99598005149	ATP binding site [chemical binding]; other site
99598005150	Q-loop/lid; other site
99598005151	ABC transporter signature motif; other site
99598005152	Walker B; other site
99598005153	D-loop; other site
99598005154	H-loop/switch region; other site
99598005155	TOBE domain; Region: TOBE_2; pfam08402
99598005156	hypothetical protein; Provisional; Region: PRK06185
99598005157	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
99598005158	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
99598005159	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
99598005160	dimer interface [polypeptide binding]; other site
99598005161	ssDNA binding site [nucleotide binding]; other site
99598005162	tetramer (dimer of dimers) interface [polypeptide binding]; other site
99598005163	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
99598005164	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99598005165	Walker A/P-loop; other site
99598005166	ATP binding site [chemical binding]; other site
99598005167	Q-loop/lid; other site
99598005168	ABC transporter signature motif; other site
99598005169	Walker B; other site
99598005170	D-loop; other site
99598005171	H-loop/switch region; other site
99598005172	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
99598005173	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99598005174	Walker A/P-loop; other site
99598005175	ATP binding site [chemical binding]; other site
99598005176	Q-loop/lid; other site
99598005177	ABC transporter signature motif; other site
99598005178	Walker B; other site
99598005179	D-loop; other site
99598005180	H-loop/switch region; other site
99598005181	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
99598005182	Uncharacterized conserved protein [Function unknown]; Region: COG5464
99598005183	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
99598005184	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
99598005185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598005186	S-adenosylmethionine binding site [chemical binding]; other site
99598005187	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
99598005188	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
99598005189	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
99598005190	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
99598005191	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
99598005192	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
99598005193	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
99598005194	MgtC family; Region: MgtC; pfam02308
99598005195	recombination protein F; Reviewed; Region: recF; PRK00064
99598005196	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
99598005197	Walker A/P-loop; other site
99598005198	ATP binding site [chemical binding]; other site
99598005199	Q-loop/lid; other site
99598005200	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598005201	ABC transporter signature motif; other site
99598005202	Walker B; other site
99598005203	D-loop; other site
99598005204	H-loop/switch region; other site
99598005205	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
99598005206	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
99598005207	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99598005208	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
99598005209	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598005210	motif II; other site
99598005211	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
99598005212	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
99598005213	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
99598005214	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
99598005215	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
99598005216	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
99598005217	S-layer homology domain; Region: SLH; pfam00395
99598005218	S-layer homology domain; Region: SLH; pfam00395
99598005219	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
99598005220	translation initiation factor IF-2; Region: IF-2; TIGR00487
99598005221	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
99598005222	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
99598005223	G1 box; other site
99598005224	putative GEF interaction site [polypeptide binding]; other site
99598005225	GTP/Mg2+ binding site [chemical binding]; other site
99598005226	Switch I region; other site
99598005227	G2 box; other site
99598005228	G3 box; other site
99598005229	Switch II region; other site
99598005230	G4 box; other site
99598005231	G5 box; other site
99598005232	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
99598005233	Translation-initiation factor 2; Region: IF-2; pfam11987
99598005234	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
99598005235	Protein of unknown function (DUF448); Region: DUF448; pfam04296
99598005236	putative RNA binding cleft [nucleotide binding]; other site
99598005237	NusA N-terminal domain; Region: NusA_N; pfam08529
99598005238	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
99598005239	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
99598005240	RNA binding site [nucleotide binding]; other site
99598005241	homodimer interface [polypeptide binding]; other site
99598005242	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
99598005243	G-X-X-G motif; other site
99598005244	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
99598005245	G-X-X-G motif; other site
99598005246	ribosome maturation protein RimP; Reviewed; Region: PRK00092
99598005247	Sm and related proteins; Region: Sm_like; cl00259
99598005248	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
99598005249	putative oligomer interface [polypeptide binding]; other site
99598005250	putative RNA binding site [nucleotide binding]; other site
99598005251	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
99598005252	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598005253	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598005254	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
99598005255	HD domain; Region: HD_4; pfam13328
99598005256	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
99598005257	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
99598005258	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99598005259	active site
99598005260	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
99598005261	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598005262	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598005263	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598005264	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598005265	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
99598005266	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598005267	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598005268	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598005269	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
99598005270	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598005271	S-adenosylmethionine binding site [chemical binding]; other site
99598005272	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348
99598005273	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
99598005274	putative ligand binding site [chemical binding]; other site
99598005275	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
99598005276	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
99598005277	TM-ABC transporter signature motif; other site
99598005278	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598005279	putative active site [active]
99598005280	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
99598005281	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
99598005282	TM-ABC transporter signature motif; other site
99598005283	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
99598005284	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
99598005285	Walker A/P-loop; other site
99598005286	ATP binding site [chemical binding]; other site
99598005287	Q-loop/lid; other site
99598005288	ABC transporter signature motif; other site
99598005289	Walker B; other site
99598005290	D-loop; other site
99598005291	H-loop/switch region; other site
99598005292	Uncharacterized conserved protein [Function unknown]; Region: COG5464
99598005293	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
99598005294	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
99598005295	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
99598005296	Walker A/P-loop; other site
99598005297	ATP binding site [chemical binding]; other site
99598005298	Q-loop/lid; other site
99598005299	ABC transporter signature motif; other site
99598005300	Walker B; other site
99598005301	D-loop; other site
99598005302	H-loop/switch region; other site
99598005303	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598005304	putative active site [active]
99598005305	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
99598005306	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
99598005307	catalytic core [active]
99598005308	glucokinase; Provisional; Region: glk; PRK00292
99598005309	glucokinase, proteobacterial type; Region: glk; TIGR00749
99598005310	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
99598005311	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
99598005312	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
99598005313	putative active site [active]
99598005314	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598005315	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598005316	Walker A/P-loop; other site
99598005317	ATP binding site [chemical binding]; other site
99598005318	Q-loop/lid; other site
99598005319	ABC transporter signature motif; other site
99598005320	Walker B; other site
99598005321	D-loop; other site
99598005322	H-loop/switch region; other site
99598005323	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
99598005324	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
99598005325	Integral membrane protein DUF92; Region: DUF92; pfam01940
99598005326	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
99598005327	active site
99598005328	metal binding site [ion binding]; metal-binding site
99598005329	Lipase (class 2); Region: Lipase_2; pfam01674
99598005330	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
99598005331	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
99598005332	binding surface
99598005333	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598005334	TPR motif; other site
99598005335	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
99598005336	RNA methyltransferase, RsmE family; Region: TIGR00046
99598005337	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
99598005338	ferredoxin-sulfite reductase; Region: sir; TIGR02042
99598005339	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
99598005340	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
99598005341	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
99598005342	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
99598005343	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
99598005344	DNA-binding interface [nucleotide binding]; DNA binding site
99598005345	Protein of unknown function (DUF3257); Region: DUF3257; pfam11645
99598005346	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598005347	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
99598005348	ligand binding site [chemical binding]; other site
99598005349	flexible hinge region; other site
99598005350	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
99598005351	putative switch regulator; other site
99598005352	non-specific DNA interactions [nucleotide binding]; other site
99598005353	DNA binding site [nucleotide binding]
99598005354	sequence specific DNA binding site [nucleotide binding]; other site
99598005355	putative cAMP binding site [chemical binding]; other site
99598005356	S-layer homology domain; Region: SLH; pfam00395
99598005357	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
99598005358	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
99598005359	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
99598005360	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
99598005361	Ligand binding site; other site
99598005362	Putative Catalytic site; other site
99598005363	DXD motif; other site
99598005364	Predicted membrane protein [Function unknown]; Region: COG2246
99598005365	GtrA-like protein; Region: GtrA; pfam04138
99598005366	FO synthase subunit 2; Reviewed; Region: PRK07360
99598005367	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598005368	FeS/SAM binding site; other site
99598005369	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
99598005370	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
99598005371	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
99598005372	putative dimer interface [polypeptide binding]; other site
99598005373	active site pocket [active]
99598005374	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
99598005375	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598005376	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598005377	ligand binding site [chemical binding]; other site
99598005378	flexible hinge region; other site
99598005379	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
99598005380	putative switch regulator; other site
99598005381	non-specific DNA interactions [nucleotide binding]; other site
99598005382	DNA binding site [nucleotide binding]
99598005383	sequence specific DNA binding site [nucleotide binding]; other site
99598005384	putative cAMP binding site [chemical binding]; other site
99598005385	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
99598005386	Bacterial sugar transferase; Region: Bac_transf; pfam02397
99598005387	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
99598005388	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598005389	dimer interface [polypeptide binding]; other site
99598005390	conserved gate region; other site
99598005391	putative PBP binding loops; other site
99598005392	ABC-ATPase subunit interface; other site
99598005393	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
99598005394	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
99598005395	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
99598005396	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
99598005397	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
99598005398	Chain length determinant protein; Region: Wzz; cl15801
99598005399	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
99598005400	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
99598005401	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598005402	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598005403	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598005404	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598005405	Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316
99598005406	Methyltransferase domain; Region: Methyltransf_23; pfam13489
99598005407	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598005408	S-adenosylmethionine binding site [chemical binding]; other site
99598005409	colanic acid exporter; Provisional; Region: PRK10459
99598005410	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
99598005411	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598005412	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598005413	Methyltransferase domain; Region: Methyltransf_23; pfam13489
99598005414	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598005415	S-adenosylmethionine binding site [chemical binding]; other site
99598005416	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
99598005417	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
99598005418	NADP binding site [chemical binding]; other site
99598005419	active site
99598005420	putative substrate binding site [chemical binding]; other site
99598005421	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
99598005422	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
99598005423	NADP-binding site; other site
99598005424	homotetramer interface [polypeptide binding]; other site
99598005425	substrate binding site [chemical binding]; other site
99598005426	homodimer interface [polypeptide binding]; other site
99598005427	active site
99598005428	Bacterial sugar transferase; Region: Bac_transf; pfam02397
99598005429	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
99598005430	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598005431	putative ADP-binding pocket [chemical binding]; other site
99598005432	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
99598005433	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
99598005434	putative NAD(P) binding site [chemical binding]; other site
99598005435	active site
99598005436	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
99598005437	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
99598005438	NAD binding site [chemical binding]; other site
99598005439	substrate binding site [chemical binding]; other site
99598005440	homodimer interface [polypeptide binding]; other site
99598005441	active site
99598005442	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
99598005443	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
99598005444	substrate binding site; other site
99598005445	tetramer interface; other site
99598005446	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
99598005447	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
99598005448	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
99598005449	NADP binding site [chemical binding]; other site
99598005450	active site
99598005451	putative substrate binding site [chemical binding]; other site
99598005452	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
99598005453	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598005454	active site
99598005455	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
99598005456	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598005457	active site
99598005458	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
99598005459	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598005460	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
99598005461	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
99598005462	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
99598005463	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
99598005464	Chain length determinant protein; Region: Wzz; pfam02706
99598005465	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
99598005466	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
99598005467	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99598005468	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
99598005469	Bacterial sugar transferase; Region: Bac_transf; pfam02397
99598005470	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
99598005471	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
99598005472	NAD binding site [chemical binding]; other site
99598005473	homodimer interface [polypeptide binding]; other site
99598005474	active site
99598005475	substrate binding site [chemical binding]; other site
99598005476	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
99598005477	Protein of unknown function (DUF563); Region: DUF563; pfam04577
99598005478	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
99598005479	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
99598005480	Bacterial sugar transferase; Region: Bac_transf; pfam02397
99598005481	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
99598005482	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
99598005483	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
99598005484	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598005485	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598005486	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
99598005487	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598005488	active site
99598005489	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598005490	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
99598005491	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
99598005492	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
99598005493	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
99598005494	Chain length determinant protein; Region: Wzz; pfam02706
99598005495	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
99598005496	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
99598005497	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99598005498	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
99598005499	Aspartase; Region: Aspartase; cd01357
99598005500	active sites [active]
99598005501	tetramer interface [polypeptide binding]; other site
99598005502	Uncharacterized conserved protein [Function unknown]; Region: COG2006
99598005503	Domain of unknown function (DUF362); Region: DUF362; pfam04015
99598005504	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
99598005505	dimer interface [polypeptide binding]; other site
99598005506	substrate binding site [chemical binding]; other site
99598005507	metal binding sites [ion binding]; metal-binding site
99598005508	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
99598005509	tetramerization interface [polypeptide binding]; other site
99598005510	active site
99598005511	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
99598005512	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
99598005513	hypothetical protein; Provisional; Region: PRK07394
99598005514	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
99598005515	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
99598005516	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99598005517	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99598005518	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
99598005519	dimerization interface [polypeptide binding]; other site
99598005520	HEAT repeats; Region: HEAT_2; pfam13646
99598005521	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
99598005522	HEAT repeats; Region: HEAT_2; pfam13646
99598005523	HEAT repeats; Region: HEAT_2; pfam13646
99598005524	HEAT repeats; Region: HEAT_2; pfam13646
99598005525	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
99598005526	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
99598005527	iron-sulfur cluster [ion binding]; other site
99598005528	[2Fe-2S] cluster binding site [ion binding]; other site
99598005529	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
99598005530	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
99598005531	Circadian oscillating protein COP23; Region: COP23; pfam14218
99598005532	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
99598005533	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
99598005534	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
99598005535	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598005536	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598005537	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
99598005538	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
99598005539	[4Fe-4S] binding site [ion binding]; other site
99598005540	molybdopterin cofactor binding site; other site
99598005541	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
99598005542	molybdopterin cofactor binding site; other site
99598005543	Predicted membrane protein [Function unknown]; Region: COG3431
99598005544	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
99598005545	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
99598005546	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
99598005547	phosphopeptide binding site; other site
99598005548	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
99598005549	CHAT domain; Region: CHAT; cl17868
99598005550	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
99598005551	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
99598005552	phosphopeptide binding site; other site
99598005553	Double zinc ribbon; Region: DZR; pfam12773
99598005554	Protein phosphatase 2C; Region: PP2C; pfam00481
99598005555	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
99598005556	active site
99598005557	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
99598005558	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99598005559	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598005560	active site
99598005561	phosphorylation site [posttranslational modification]
99598005562	intermolecular recognition site; other site
99598005563	dimerization interface [polypeptide binding]; other site
99598005564	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598005565	DNA binding residues [nucleotide binding]
99598005566	dimerization interface [polypeptide binding]; other site
99598005567	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
99598005568	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598005569	active site
99598005570	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
99598005571	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
99598005572	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
99598005573	active site
99598005574	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
99598005575	amidase catalytic site [active]
99598005576	Zn binding residues [ion binding]; other site
99598005577	substrate binding site [chemical binding]; other site
99598005578	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
99598005579	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
99598005580	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
99598005581	dimerization interface [polypeptide binding]; other site
99598005582	active site
99598005583	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
99598005584	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
99598005585	enolase; Provisional; Region: eno; PRK00077
99598005586	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
99598005587	dimer interface [polypeptide binding]; other site
99598005588	metal binding site [ion binding]; metal-binding site
99598005589	substrate binding pocket [chemical binding]; other site
99598005590	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
99598005591	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
99598005592	dimer interface [polypeptide binding]; other site
99598005593	active site
99598005594	metal binding site [ion binding]; metal-binding site
99598005595	glutathione binding site [chemical binding]; other site
99598005596	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
99598005597	Clp amino terminal domain; Region: Clp_N; pfam02861
99598005598	Clp amino terminal domain; Region: Clp_N; pfam02861
99598005599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598005600	Walker A motif; other site
99598005601	ATP binding site [chemical binding]; other site
99598005602	Walker B motif; other site
99598005603	arginine finger; other site
99598005604	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598005605	Walker A motif; other site
99598005606	ATP binding site [chemical binding]; other site
99598005607	Walker B motif; other site
99598005608	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
99598005609	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598005610	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598005611	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598005612	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598005613	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
99598005614	heat shock protein 90; Provisional; Region: PRK05218
99598005615	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598005616	ATP binding site [chemical binding]; other site
99598005617	Mg2+ binding site [ion binding]; other site
99598005618	G-X-G motif; other site
99598005619	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
99598005620	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
99598005621	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
99598005622	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
99598005623	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
99598005624	Haemolytic domain; Region: Haemolytic; pfam01809
99598005625	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
99598005626	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99598005627	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
99598005628	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598005629	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
99598005630	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
99598005631	putative active site [active]
99598005632	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598005633	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598005634	Walker A/P-loop; other site
99598005635	ATP binding site [chemical binding]; other site
99598005636	Q-loop/lid; other site
99598005637	ABC transporter signature motif; other site
99598005638	Walker B; other site
99598005639	D-loop; other site
99598005640	H-loop/switch region; other site
99598005641	hydrolase, alpha/beta fold family protein; Region: PLN02824
99598005642	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
99598005643	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
99598005644	putative catalytic residue [active]
99598005645	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
99598005646	putative nucleotide binding site [chemical binding]; other site
99598005647	uridine monophosphate binding site [chemical binding]; other site
99598005648	homohexameric interface [polypeptide binding]; other site
99598005649	ribosome recycling factor; Reviewed; Region: frr; PRK00083
99598005650	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
99598005651	hinge region; other site
99598005652	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
99598005653	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99598005654	CAAX protease self-immunity; Region: Abi; pfam02517
99598005655	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
99598005656	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
99598005657	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
99598005658	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
99598005659	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
99598005660	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
99598005661	Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596
99598005662	Predicted integral membrane protein [Function unknown]; Region: COG0762
99598005663	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
99598005664	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
99598005665	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
99598005666	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
99598005667	Protein of unknown function (DUF98); Region: DUF98; pfam01947
99598005668	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
99598005669	cytochrome c biogenesis protein; Region: ccsA; CHL00045
99598005670	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
99598005671	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
99598005672	Ligand Binding Site [chemical binding]; other site
99598005673	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
99598005674	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
99598005675	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598005676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598005677	active site
99598005678	phosphorylation site [posttranslational modification]
99598005679	intermolecular recognition site; other site
99598005680	dimerization interface [polypeptide binding]; other site
99598005681	Response regulator receiver domain; Region: Response_reg; pfam00072
99598005682	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598005683	active site
99598005684	phosphorylation site [posttranslational modification]
99598005685	intermolecular recognition site; other site
99598005686	dimerization interface [polypeptide binding]; other site
99598005687	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
99598005688	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598005689	binding surface
99598005690	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598005691	TPR motif; other site
99598005692	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598005693	dimerization interface [polypeptide binding]; other site
99598005694	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
99598005695	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
99598005696	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
99598005697	dimer interface [polypeptide binding]; other site
99598005698	putative CheW interface [polypeptide binding]; other site
99598005699	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
99598005700	putative binding surface; other site
99598005701	active site
99598005702	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
99598005703	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
99598005704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598005705	ATP binding site [chemical binding]; other site
99598005706	Mg2+ binding site [ion binding]; other site
99598005707	G-X-G motif; other site
99598005708	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
99598005709	Response regulator receiver domain; Region: Response_reg; pfam00072
99598005710	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598005711	active site
99598005712	phosphorylation site [posttranslational modification]
99598005713	intermolecular recognition site; other site
99598005714	dimerization interface [polypeptide binding]; other site
99598005715	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
99598005716	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
99598005717	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
99598005718	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
99598005719	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
99598005720	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
99598005721	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
99598005722	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598005723	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598005724	structural tetrad; other site
99598005725	light-harvesting-like protein 3; Provisional; Region: PLN00014
99598005726	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
99598005727	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
99598005728	hexamer interface [polypeptide binding]; other site
99598005729	ligand binding site [chemical binding]; other site
99598005730	putative active site [active]
99598005731	NAD(P) binding site [chemical binding]; other site
99598005732	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
99598005733	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
99598005734	Dehydratase family; Region: ILVD_EDD; cl00340
99598005735	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
99598005736	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
99598005737	Domain of unknown function (DUF1802); Region: DUF1802; cl01755
99598005738	disulphide isomerase; Provisional; Region: PTZ00102
99598005739	malate dehydrogenase; Reviewed; Region: PRK06223
99598005740	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
99598005741	NAD(P) binding site [chemical binding]; other site
99598005742	dimer interface [polypeptide binding]; other site
99598005743	tetramer (dimer of dimers) interface [polypeptide binding]; other site
99598005744	substrate binding site [chemical binding]; other site
99598005745	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
99598005746	IHF dimer interface [polypeptide binding]; other site
99598005747	IHF - DNA interface [nucleotide binding]; other site
99598005748	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
99598005749	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99598005750	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598005751	homodimer interface [polypeptide binding]; other site
99598005752	catalytic residue [active]
99598005753	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
99598005754	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99598005755	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
99598005756	Proline dehydrogenase; Region: Pro_dh; pfam01619
99598005757	delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237
99598005758	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
99598005759	Glutamate binding site [chemical binding]; other site
99598005760	homodimer interface [polypeptide binding]; other site
99598005761	NAD binding site [chemical binding]; other site
99598005762	catalytic residues [active]
99598005763	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
99598005764	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
99598005765	2TM domain; Region: 2TM; pfam13239
99598005766	CVNH domain; Region: CVNH; pfam08881
99598005767	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598005768	ATP binding site [chemical binding]; other site
99598005769	putative Mg++ binding site [ion binding]; other site
99598005770	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598005771	nucleotide binding region [chemical binding]; other site
99598005772	ATP-binding site [chemical binding]; other site
99598005773	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
99598005774	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598005775	putative active site [active]
99598005776	heme pocket [chemical binding]; other site
99598005777	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
99598005778	phosphorylation site [posttranslational modification]
99598005779	dimer interface [polypeptide binding]; other site
99598005780	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598005781	ATP binding site [chemical binding]; other site
99598005782	Mg2+ binding site [ion binding]; other site
99598005783	G-X-G motif; other site
99598005784	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
99598005785	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
99598005786	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
99598005787	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
99598005788	beta-phosphoglucomutase; Region: bPGM; TIGR01990
99598005789	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598005790	sucrose synthase; Region: sucr_synth; TIGR02470
99598005791	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
99598005792	putative ADP-binding pocket [chemical binding]; other site
99598005793	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598005794	ligand binding site [chemical binding]; other site
99598005795	flexible hinge region; other site
99598005796	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
99598005797	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
99598005798	putative active site [active]
99598005799	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598005800	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
99598005801	Walker A/P-loop; other site
99598005802	ATP binding site [chemical binding]; other site
99598005803	Q-loop/lid; other site
99598005804	ABC transporter signature motif; other site
99598005805	Walker B; other site
99598005806	D-loop; other site
99598005807	H-loop/switch region; other site
99598005808	HlyD family secretion protein; Region: HlyD; pfam00529
99598005809	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
99598005810	E3 interaction surface; other site
99598005811	lipoyl attachment site [posttranslational modification]; other site
99598005812	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598005813	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
99598005814	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
99598005815	FOG: CBS domain [General function prediction only]; Region: COG0517
99598005816	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
99598005817	PAS domain S-box; Region: sensory_box; TIGR00229
99598005818	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598005819	putative active site [active]
99598005820	heme pocket [chemical binding]; other site
99598005821	PAS domain S-box; Region: sensory_box; TIGR00229
99598005822	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598005823	putative active site [active]
99598005824	heme pocket [chemical binding]; other site
99598005825	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598005826	PAS fold; Region: PAS_3; pfam08447
99598005827	putative active site [active]
99598005828	heme pocket [chemical binding]; other site
99598005829	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598005830	PAS fold; Region: PAS_3; pfam08447
99598005831	putative active site [active]
99598005832	heme pocket [chemical binding]; other site
99598005833	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
99598005834	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598005835	putative active site [active]
99598005836	heme pocket [chemical binding]; other site
99598005837	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598005838	dimer interface [polypeptide binding]; other site
99598005839	phosphorylation site [posttranslational modification]
99598005840	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598005841	ATP binding site [chemical binding]; other site
99598005842	Mg2+ binding site [ion binding]; other site
99598005843	G-X-G motif; other site
99598005844	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598005845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598005846	active site
99598005847	phosphorylation site [posttranslational modification]
99598005848	intermolecular recognition site; other site
99598005849	dimerization interface [polypeptide binding]; other site
99598005850	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598005851	dimerization interface [polypeptide binding]; other site
99598005852	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
99598005853	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598005854	putative active site [active]
99598005855	heme pocket [chemical binding]; other site
99598005856	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598005857	dimer interface [polypeptide binding]; other site
99598005858	phosphorylation site [posttranslational modification]
99598005859	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598005860	ATP binding site [chemical binding]; other site
99598005861	Mg2+ binding site [ion binding]; other site
99598005862	G-X-G motif; other site
99598005863	Pirin-related protein [General function prediction only]; Region: COG1741
99598005864	Pirin; Region: Pirin; pfam02678
99598005865	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
99598005866	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
99598005867	dimerization interface [polypeptide binding]; other site
99598005868	DPS ferroxidase diiron center [ion binding]; other site
99598005869	ion pore; other site
99598005870	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
99598005871	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
99598005872	FAD binding site [chemical binding]; other site
99598005873	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
99598005874	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
99598005875	active site
99598005876	HIGH motif; other site
99598005877	dimer interface [polypeptide binding]; other site
99598005878	KMSKS motif; other site
99598005879	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
99598005880	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
99598005881	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598005882	FeS/SAM binding site; other site
99598005883	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
99598005884	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
99598005885	TAP-like protein; Region: Abhydrolase_4; pfam08386
99598005886	Protein of unknown function (DUF721); Region: DUF721; cl02324
99598005887	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
99598005888	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
99598005889	substrate binding site [chemical binding]; other site
99598005890	oxyanion hole (OAH) forming residues; other site
99598005891	trimer interface [polypeptide binding]; other site
99598005892	Double zinc ribbon; Region: DZR; pfam12773
99598005893	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
99598005894	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598005895	active site
99598005896	ATP binding site [chemical binding]; other site
99598005897	substrate binding site [chemical binding]; other site
99598005898	activation loop (A-loop); other site
99598005899	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598005900	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598005901	structural tetrad; other site
99598005902	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
99598005903	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
99598005904	dimer interface [polypeptide binding]; other site
99598005905	tetramer interface [polypeptide binding]; other site
99598005906	PYR/PP interface [polypeptide binding]; other site
99598005907	TPP binding site [chemical binding]; other site
99598005908	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
99598005909	TPP-binding site; other site
99598005910	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
99598005911	homooctamer interface [polypeptide binding]; other site
99598005912	active site
99598005913	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598005914	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598005915	active site
99598005916	phosphorylation site [posttranslational modification]
99598005917	intermolecular recognition site; other site
99598005918	dimerization interface [polypeptide binding]; other site
99598005919	PAS fold; Region: PAS; pfam00989
99598005920	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598005921	putative active site [active]
99598005922	heme pocket [chemical binding]; other site
99598005923	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
99598005924	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99598005925	metal binding site [ion binding]; metal-binding site
99598005926	active site
99598005927	I-site; other site
99598005928	maltose O-acetyltransferase; Provisional; Region: PRK10092
99598005929	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
99598005930	active site
99598005931	substrate binding site [chemical binding]; other site
99598005932	trimer interface [polypeptide binding]; other site
99598005933	CoA binding site [chemical binding]; other site
99598005934	Calcium binding; Region: Calci_bind_CcbP; pfam11535
99598005935	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598005936	putative active site [active]
99598005937	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
99598005938	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
99598005939	substrate binding site [chemical binding]; other site
99598005940	dimer interface [polypeptide binding]; other site
99598005941	ATP binding site [chemical binding]; other site
99598005942	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
99598005943	nucleoside/Zn binding site; other site
99598005944	dimer interface [polypeptide binding]; other site
99598005945	catalytic motif [active]
99598005946	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
99598005947	active site
99598005948	dimerization interface [polypeptide binding]; other site
99598005949	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
99598005950	dimer interface [polypeptide binding]; other site
99598005951	ADP-ribose binding site [chemical binding]; other site
99598005952	active site
99598005953	nudix motif; other site
99598005954	metal binding site [ion binding]; metal-binding site
99598005955	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
99598005956	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
99598005957	active site
99598005958	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
99598005959	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598005960	putative active site [active]
99598005961	Peptidase family M48; Region: Peptidase_M48; pfam01435
99598005962	Circadian oscillating protein COP23; Region: COP23; pfam14218
99598005963	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
99598005964	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
99598005965	dimer interface [polypeptide binding]; other site
99598005966	anticodon binding site; other site
99598005967	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
99598005968	homodimer interface [polypeptide binding]; other site
99598005969	motif 1; other site
99598005970	active site
99598005971	motif 2; other site
99598005972	GAD domain; Region: GAD; pfam02938
99598005973	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
99598005974	active site
99598005975	motif 3; other site
99598005976	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
99598005977	Chain length determinant protein; Region: Wzz; pfam02706
99598005978	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
99598005979	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
99598005980	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99598005981	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598005982	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598005983	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
99598005984	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
99598005985	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
99598005986	active site
99598005987	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
99598005988	O-Antigen ligase; Region: Wzy_C; pfam04932
99598005989	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
99598005990	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598005991	putative ADP-binding pocket [chemical binding]; other site
99598005992	serine O-acetyltransferase; Region: cysE; TIGR01172
99598005993	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
99598005994	trimer interface [polypeptide binding]; other site
99598005995	active site
99598005996	substrate binding site [chemical binding]; other site
99598005997	CoA binding site [chemical binding]; other site
99598005998	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598005999	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598006000	BNR repeat-like domain; Region: BNR_2; pfam13088
99598006001	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
99598006002	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241
99598006003	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
99598006004	DNA protecting protein DprA; Region: dprA; TIGR00732
99598006005	XisI protein; Region: XisI; pfam08869
99598006006	Psb28 protein; Region: Psb28; cl04326
99598006007	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
99598006008	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
99598006009	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
99598006010	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
99598006011	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
99598006012	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
99598006013	active site
99598006014	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
99598006015	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
99598006016	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
99598006017	active site
99598006018	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551
99598006019	active site
99598006020	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
99598006021	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
99598006022	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
99598006023	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
99598006024	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
99598006025	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99598006026	NAD(P) binding site [chemical binding]; other site
99598006027	active site
99598006028	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
99598006029	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
99598006030	Competence protein; Region: Competence; pfam03772
99598006031	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
99598006032	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
99598006033	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
99598006034	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
99598006035	Zn2+ binding site [ion binding]; other site
99598006036	Mg2+ binding site [ion binding]; other site
99598006037	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
99598006038	synthetase active site [active]
99598006039	NTP binding site [chemical binding]; other site
99598006040	metal binding site [ion binding]; metal-binding site
99598006041	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
99598006042	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
99598006043	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598006044	putative active site [active]
99598006045	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99598006046	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99598006047	HlyD family secretion protein; Region: HlyD; pfam00529
99598006048	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
99598006049	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598006050	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
99598006051	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598006052	putative substrate translocation pore; other site
99598006053	Protein of unknown function (DUF433); Region: DUF433; pfam04255
99598006054	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
99598006055	putative active site [active]
99598006056	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
99598006057	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99598006058	Walker A/P-loop; other site
99598006059	ATP binding site [chemical binding]; other site
99598006060	Q-loop/lid; other site
99598006061	ABC transporter signature motif; other site
99598006062	Walker B; other site
99598006063	D-loop; other site
99598006064	H-loop/switch region; other site
99598006065	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
99598006066	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99598006067	Walker A/P-loop; other site
99598006068	ATP binding site [chemical binding]; other site
99598006069	Q-loop/lid; other site
99598006070	ABC transporter signature motif; other site
99598006071	Walker B; other site
99598006072	D-loop; other site
99598006073	H-loop/switch region; other site
99598006074	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
99598006075	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
99598006076	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598006077	Coenzyme A binding pocket [chemical binding]; other site
99598006078	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598006079	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598006080	binding surface
99598006081	TPR motif; other site
99598006082	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598006083	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598006084	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598006085	binding surface
99598006086	TPR motif; other site
99598006087	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598006088	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598006089	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598006090	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598006091	binding surface
99598006092	TPR motif; other site
99598006093	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598006094	PBP superfamily domain; Region: PBP_like_2; pfam12849
99598006095	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
99598006096	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
99598006097	trimer interface [polypeptide binding]; other site
99598006098	active site
99598006099	substrate binding site [chemical binding]; other site
99598006100	CoA binding site [chemical binding]; other site
99598006101	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313
99598006102	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
99598006103	Phage protein D [General function prediction only]; Region: COG3500
99598006104	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
99598006105	PAAR motif; Region: PAAR_motif; pfam05488
99598006106	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
99598006107	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
99598006108	phage tail protein domain; Region: tail_TIGR02242
99598006109	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
99598006110	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598006111	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
99598006112	structural tetrad; other site
99598006113	Predicted membrane protein [Function unknown]; Region: COG1470
99598006114	dihydroorotase; Provisional; Region: PRK07369
99598006115	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
99598006116	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
99598006117	active site
99598006118	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
99598006119	catalytic core [active]
99598006120	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
99598006121	catalytic core [active]
99598006122	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
99598006123	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99598006124	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598006125	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
99598006126	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
99598006127	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598006128	substrate binding pocket [chemical binding]; other site
99598006129	membrane-bound complex binding site; other site
99598006130	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
99598006131	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
99598006132	Dienelactone hydrolase family; Region: DLH; pfam01738
99598006133	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
99598006134	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
99598006135	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
99598006136	dimer interface [polypeptide binding]; other site
99598006137	putative metal binding site [ion binding]; other site
99598006138	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
99598006139	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598006140	substrate binding pocket [chemical binding]; other site
99598006141	membrane-bound complex binding site; other site
99598006142	hinge residues; other site
99598006143	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
99598006144	active site
99598006145	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
99598006146	dimer interface [polypeptide binding]; other site
99598006147	non-prolyl cis peptide bond; other site
99598006148	insertion regions; other site
99598006149	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
99598006150	Epoxide hydrolase N terminus; Region: EHN; pfam06441
99598006151	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
99598006152	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
99598006153	clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934
99598006154	NADP binding site [chemical binding]; other site
99598006155	homotetramer interface [polypeptide binding]; other site
99598006156	homodimer interface [polypeptide binding]; other site
99598006157	active site
99598006158	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598006159	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99598006160	putative substrate translocation pore; other site
99598006161	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598006162	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
99598006163	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
99598006164	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
99598006165	Methyltransferase domain; Region: Methyltransf_23; pfam13489
99598006166	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598006167	S-adenosylmethionine binding site [chemical binding]; other site
99598006168	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
99598006169	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598006170	substrate binding pocket [chemical binding]; other site
99598006171	membrane-bound complex binding site; other site
99598006172	hinge residues; other site
99598006173	YcxB-like protein; Region: YcxB; pfam14317
99598006174	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
99598006175	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99598006176	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598006177	homodimer interface [polypeptide binding]; other site
99598006178	catalytic residue [active]
99598006179	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
99598006180	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
99598006181	PBP superfamily domain; Region: PBP_like_2; cl17296
99598006182	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598006183	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
99598006184	binding surface
99598006185	TPR motif; other site
99598006186	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
99598006187	Transposase [DNA replication, recombination, and repair]; Region: COG5421
99598006188	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598006189	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598006190	binding surface
99598006191	TPR motif; other site
99598006192	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598006193	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598006194	binding surface
99598006195	TPR motif; other site
99598006196	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598006197	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598006198	CHAT domain; Region: CHAT; pfam12770
99598006199	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
99598006200	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
99598006201	homodimer interface [polypeptide binding]; other site
99598006202	substrate-cofactor binding pocket; other site
99598006203	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598006204	catalytic residue [active]
99598006205	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
99598006206	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
99598006207	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
99598006208	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
99598006209	catalytic triad [active]
99598006210	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
99598006211	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
99598006212	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
99598006213	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
99598006214	Histidine kinase; Region: HisKA_3; pfam07730
99598006215	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598006216	ATP binding site [chemical binding]; other site
99598006217	Mg2+ binding site [ion binding]; other site
99598006218	G-X-G motif; other site
99598006219	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99598006220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598006221	active site
99598006222	phosphorylation site [posttranslational modification]
99598006223	intermolecular recognition site; other site
99598006224	dimerization interface [polypeptide binding]; other site
99598006225	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598006226	DNA binding residues [nucleotide binding]
99598006227	dimerization interface [polypeptide binding]; other site
99598006228	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
99598006229	nucleoside/Zn binding site; other site
99598006230	dimer interface [polypeptide binding]; other site
99598006231	catalytic motif [active]
99598006232	Ion transport protein; Region: Ion_trans; pfam00520
99598006233	Ion channel; Region: Ion_trans_2; pfam07885
99598006234	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
99598006235	Double zinc ribbon; Region: DZR; pfam12773
99598006236	TIGR04222 domain; Region: near_uncomplex
99598006237	hypothetical protein; Provisional; Region: PRK05409
99598006238	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
99598006239	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
99598006240	S-layer homology domain; Region: SLH; pfam00395
99598006241	S-layer homology domain; Region: SLH; pfam00395
99598006242	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
99598006243	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
99598006244	dimer interface [polypeptide binding]; other site
99598006245	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598006246	catalytic residue [active]
99598006247	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
99598006248	Dynamin family; Region: Dynamin_N; pfam00350
99598006249	G1 box; other site
99598006250	GTP/Mg2+ binding site [chemical binding]; other site
99598006251	G2 box; other site
99598006252	Switch I region; other site
99598006253	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
99598006254	G3 box; other site
99598006255	Switch II region; other site
99598006256	GTP/Mg2+ binding site [chemical binding]; other site
99598006257	G4 box; other site
99598006258	G5 box; other site
99598006259	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
99598006260	Dynamin family; Region: Dynamin_N; pfam00350
99598006261	G1 box; other site
99598006262	GTP/Mg2+ binding site [chemical binding]; other site
99598006263	G2 box; other site
99598006264	Switch I region; other site
99598006265	G3 box; other site
99598006266	Switch II region; other site
99598006267	G4 box; other site
99598006268	G5 box; other site
99598006269	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99598006270	HSP70 interaction site [polypeptide binding]; other site
99598006271	Uncharacterized conserved protein [Function unknown]; Region: COG5464
99598006272	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
99598006273	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
99598006274	AMIN domain; Region: AMIN; pfam11741
99598006275	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
99598006276	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99598006277	N-terminal plug; other site
99598006278	ligand-binding site [chemical binding]; other site
99598006279	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598006280	salt bridge; other site
99598006281	non-specific DNA binding site [nucleotide binding]; other site
99598006282	sequence-specific DNA binding site [nucleotide binding]; other site
99598006283	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912
99598006284	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
99598006285	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99598006286	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598006287	putative active site [active]
99598006288	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598006289	putative active site [active]
99598006290	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
99598006291	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
99598006292	dimer interface [polypeptide binding]; other site
99598006293	decamer (pentamer of dimers) interface [polypeptide binding]; other site
99598006294	catalytic triad [active]
99598006295	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598006296	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
99598006297	putative ADP-binding pocket [chemical binding]; other site
99598006298	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598006299	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
99598006300	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
99598006301	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598006302	active site
99598006303	N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476
99598006304	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
99598006305	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
99598006306	active site
99598006307	substrate binding site [chemical binding]; other site
99598006308	metal binding site [ion binding]; metal-binding site
99598006309	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
99598006310	DHH family; Region: DHH; pfam01368
99598006311	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
99598006312	catalytic core [active]
99598006313	citrate synthase; Provisional; Region: PRK14036
99598006314	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
99598006315	oxalacetate binding site [chemical binding]; other site
99598006316	citrylCoA binding site [chemical binding]; other site
99598006317	coenzyme A binding site [chemical binding]; other site
99598006318	catalytic triad [active]
99598006319	NADH dehydrogenase subunit 1; Region: ndhA; CHL00032
99598006320	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
99598006321	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
99598006322	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
99598006323	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
99598006324	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
99598006325	NADH dehydrogenase subunit J; Provisional; Region: PRK06439
99598006326	NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015
99598006327	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
99598006328	ATP-NAD kinase; Region: NAD_kinase; pfam01513
99598006329	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
99598006330	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
99598006331	Transposase; Region: DEDD_Tnp_IS110; pfam01548
99598006332	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
99598006333	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
99598006334	GTPase Era; Reviewed; Region: era; PRK00089
99598006335	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
99598006336	G1 box; other site
99598006337	GTP/Mg2+ binding site [chemical binding]; other site
99598006338	Switch I region; other site
99598006339	G2 box; other site
99598006340	Switch II region; other site
99598006341	G3 box; other site
99598006342	G4 box; other site
99598006343	G5 box; other site
99598006344	KH domain; Region: KH_2; pfam07650
99598006345	two component system sensor kinase SsrB; Provisional; Region: PRK15369
99598006346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598006347	active site
99598006348	phosphorylation site [posttranslational modification]
99598006349	intermolecular recognition site; other site
99598006350	dimerization interface [polypeptide binding]; other site
99598006351	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598006352	DNA binding residues [nucleotide binding]
99598006353	Putative plasmid partition protein; Region: Plasmid_parti; pfam01672
99598006354	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
99598006355	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
99598006356	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598006357	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598006358	active site
99598006359	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
99598006360	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
99598006361	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598006362	putative metal binding site; other site
99598006363	Uncharacterized conserved protein [Function unknown]; Region: COG2928
99598006364	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
99598006365	putative RNA binding site [nucleotide binding]; other site
99598006366	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
99598006367	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
99598006368	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
99598006369	P loop; other site
99598006370	GTP binding site [chemical binding]; other site
99598006371	GAF domain; Region: GAF_3; pfam13492
99598006372	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
99598006373	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
99598006374	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
99598006375	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
99598006376	Malic enzyme, N-terminal domain; Region: malic; pfam00390
99598006377	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
99598006378	putative NAD(P) binding site [chemical binding]; other site
99598006379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
99598006380	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598006381	NACHT domain; Region: NACHT; pfam05729
99598006382	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
99598006383	Walker A motif; other site
99598006384	Walker A/P-loop; other site
99598006385	ATP binding site [chemical binding]; other site
99598006386	ATP binding site [chemical binding]; other site
99598006387	Walker B motif; other site
99598006388	HEAT repeats; Region: HEAT_2; pfam13646
99598006389	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
99598006390	HEAT repeats; Region: HEAT_2; pfam13646
99598006391	protein binding surface [polypeptide binding]; other site
99598006392	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
99598006393	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
99598006394	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598006395	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
99598006396	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598006397	ATP binding site [chemical binding]; other site
99598006398	putative Mg++ binding site [ion binding]; other site
99598006399	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598006400	nucleotide binding region [chemical binding]; other site
99598006401	ATP-binding site [chemical binding]; other site
99598006402	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
99598006403	HRDC domain; Region: HRDC; pfam00570
99598006404	NACHT domain; Region: NACHT; pfam05729
99598006405	RES domain; Region: RES; pfam08808
99598006406	hypothetical protein; Reviewed; Region: PRK12275
99598006407	four helix bundle protein; Region: TIGR02436
99598006408	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
99598006409	binding surface
99598006410	TPR motif; other site
99598006411	hydroxyglutarate oxidase; Provisional; Region: PRK11728
99598006412	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
99598006413	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
99598006414	ThiS interaction site; other site
99598006415	putative active site [active]
99598006416	tetramer interface [polypeptide binding]; other site
99598006417	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
99598006418	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
99598006419	active site
99598006420	catalytic residues [active]
99598006421	metal binding site [ion binding]; metal-binding site
99598006422	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
99598006423	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
99598006424	active site
99598006425	NTP binding site [chemical binding]; other site
99598006426	metal binding triad [ion binding]; metal-binding site
99598006427	HEPN domain; Region: HEPN; pfam05168
99598006428	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
99598006429	G1 box; other site
99598006430	GTP/Mg2+ binding site [chemical binding]; other site
99598006431	G2 box; other site
99598006432	G3 box; other site
99598006433	Switch II region; other site
99598006434	G4 box; other site
99598006435	G5 box; other site
99598006436	tellurium resistance terB-like protein; Region: terB_like; cd07177
99598006437	metal binding site [ion binding]; metal-binding site
99598006438	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
99598006439	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
99598006440	G1 box; other site
99598006441	G1 box; other site
99598006442	GTP/Mg2+ binding site [chemical binding]; other site
99598006443	GTP/Mg2+ binding site [chemical binding]; other site
99598006444	G2 box; other site
99598006445	Switch I region; other site
99598006446	G3 box; other site
99598006447	Switch II region; other site
99598006448	G4 box; other site
99598006449	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
99598006450	Protein of unknown function DUF82; Region: DUF82; pfam01927
99598006451	Protein of unknown function (DUF433); Region: DUF433; cl01030
99598006452	Bacterial Ig-like domain; Region: Big_5; pfam13205
99598006453	TIGR03943 family protein; Region: TIGR03943
99598006454	Predicted permeases [General function prediction only]; Region: COG0701
99598006455	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
99598006456	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598006457	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
99598006458	dimer interface [polypeptide binding]; other site
99598006459	phosphorylation site [posttranslational modification]
99598006460	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598006461	ATP binding site [chemical binding]; other site
99598006462	Mg2+ binding site [ion binding]; other site
99598006463	G-X-G motif; other site
99598006464	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
99598006465	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598006466	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598006467	ATP binding site [chemical binding]; other site
99598006468	Mg2+ binding site [ion binding]; other site
99598006469	G-X-G motif; other site
99598006470	Uncharacterized subfamily of  glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798
99598006471	active site
99598006472	catalytic site [active]
99598006473	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
99598006474	classical (c) SDRs; Region: SDR_c; cd05233
99598006475	NAD(P) binding site [chemical binding]; other site
99598006476	active site
99598006477	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
99598006478	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
99598006479	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
99598006480	Inward rectifier potassium channel; Region: IRK; pfam01007
99598006481	PRC-barrel domain; Region: PRC; pfam05239
99598006482	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
99598006483	PRC-barrel domain; Region: PRC; pfam05239
99598006484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
99598006485	transketolase; Reviewed; Region: PRK05899
99598006486	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
99598006487	TPP-binding site [chemical binding]; other site
99598006488	dimer interface [polypeptide binding]; other site
99598006489	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
99598006490	PYR/PP interface [polypeptide binding]; other site
99598006491	dimer interface [polypeptide binding]; other site
99598006492	TPP binding site [chemical binding]; other site
99598006493	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
99598006494	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
99598006495	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
99598006496	active site
99598006497	intersubunit interface [polypeptide binding]; other site
99598006498	catalytic residue [active]
99598006499	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
99598006500	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
99598006501	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
99598006502	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
99598006503	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
99598006504	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
99598006505	nucleotide binding site [chemical binding]; other site
99598006506	putative NEF/HSP70 interaction site [polypeptide binding]; other site
99598006507	SBD interface [polypeptide binding]; other site
99598006508	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
99598006509	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99598006510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
99598006511	O-Antigen ligase; Region: Wzy_C; pfam04932
99598006512	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
99598006513	CHAT domain; Region: CHAT; cl17868
99598006514	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
99598006515	Double zinc ribbon; Region: DZR; pfam12773
99598006516	Double zinc ribbon; Region: DZR; pfam12773
99598006517	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598006518	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598006519	active site
99598006520	ATP binding site [chemical binding]; other site
99598006521	substrate binding site [chemical binding]; other site
99598006522	activation loop (A-loop); other site
99598006523	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
99598006524	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
99598006525	ABC1 family; Region: ABC1; pfam03109
99598006526	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
99598006527	active site
99598006528	ATP binding site [chemical binding]; other site
99598006529	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
99598006530	active site
99598006531	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
99598006532	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598006533	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598006534	active site
99598006535	ATP binding site [chemical binding]; other site
99598006536	substrate binding site [chemical binding]; other site
99598006537	activation loop (A-loop); other site
99598006538	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
99598006539	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
99598006540	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
99598006541	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
99598006542	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
99598006543	Ligand Binding Site [chemical binding]; other site
99598006544	potassium-transporting ATPase subunit C; Provisional; Region: PRK14003
99598006545	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
99598006546	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99598006547	Soluble P-type ATPase [General function prediction only]; Region: COG4087
99598006548	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
99598006549	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598006550	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598006551	dimer interface [polypeptide binding]; other site
99598006552	phosphorylation site [posttranslational modification]
99598006553	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598006554	ATP binding site [chemical binding]; other site
99598006555	Mg2+ binding site [ion binding]; other site
99598006556	G-X-G motif; other site
99598006557	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99598006558	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598006559	active site
99598006560	phosphorylation site [posttranslational modification]
99598006561	intermolecular recognition site; other site
99598006562	dimerization interface [polypeptide binding]; other site
99598006563	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598006564	DNA binding residues [nucleotide binding]
99598006565	dimerization interface [polypeptide binding]; other site
99598006566	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
99598006567	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
99598006568	Ca2+ binding site [ion binding]; other site
99598006569	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
99598006570	Ca2+ binding site [ion binding]; other site
99598006571	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
99598006572	Ca2+ binding site [ion binding]; other site
99598006573	Cadherin-like repeat domain of alpha dystroglycan; Region: Dystroglycan_repeat; cd11303
99598006574	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
99598006575	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
99598006576	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
99598006577	putative substrate binding site [chemical binding]; other site
99598006578	putative ATP binding site [chemical binding]; other site
99598006579	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
99598006580	ATP-binding site [chemical binding]; other site
99598006581	Gluconate-6-phosphate binding site [chemical binding]; other site
99598006582	Shikimate kinase; Region: SKI; pfam01202
99598006583	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
99598006584	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4340
99598006585	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
99598006586	ligand binding site [chemical binding]; other site
99598006587	active site
99598006588	UGI interface [polypeptide binding]; other site
99598006589	catalytic site [active]
99598006590	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
99598006591	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
99598006592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598006593	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
99598006594	S-adenosylmethionine binding site [chemical binding]; other site
99598006595	PAS domain S-box; Region: sensory_box; TIGR00229
99598006596	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598006597	putative active site [active]
99598006598	heme pocket [chemical binding]; other site
99598006599	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
99598006600	dimer interface [polypeptide binding]; other site
99598006601	phosphorylation site [posttranslational modification]
99598006602	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598006603	ATP binding site [chemical binding]; other site
99598006604	Mg2+ binding site [ion binding]; other site
99598006605	G-X-G motif; other site
99598006606	Isochorismatase family; Region: Isochorismatase; pfam00857
99598006607	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
99598006608	catalytic triad [active]
99598006609	conserved cis-peptide bond; other site
99598006610	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
99598006611	Repair protein; Region: Repair_PSII; pfam04536
99598006612	precorrin-8X methylmutase; Validated; Region: PRK05953
99598006613	Precorrin-8X methylmutase; Region: CbiC; pfam02570
99598006614	dihydrodipicolinate reductase; Provisional; Region: PRK00048
99598006615	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
99598006616	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
99598006617	photosystem I reaction center subunit X; Reviewed; Region: PRK13214
99598006618	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
99598006619	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
99598006620	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598006621	putative active site [active]
99598006622	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598006623	TPR motif; other site
99598006624	binding surface
99598006625	CHAT domain; Region: CHAT; pfam12770
99598006626	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
99598006627	Protein of unknown function (DUF497); Region: DUF497; pfam04365
99598006628	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
99598006629	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
99598006630	P-loop, Walker A motif; other site
99598006631	Base recognition motif; other site
99598006632	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
99598006633	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598006634	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
99598006635	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598006636	structural tetrad; other site
99598006637	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
99598006638	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
99598006639	metal binding site [ion binding]; metal-binding site
99598006640	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
99598006641	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
99598006642	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598006643	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598006644	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598006645	ligand binding site [chemical binding]; other site
99598006646	flexible hinge region; other site
99598006647	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
99598006648	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
99598006649	putative active site [active]
99598006650	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598006651	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598006652	Walker A/P-loop; other site
99598006653	ATP binding site [chemical binding]; other site
99598006654	Q-loop/lid; other site
99598006655	ABC transporter signature motif; other site
99598006656	Walker B; other site
99598006657	D-loop; other site
99598006658	H-loop/switch region; other site
99598006659	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
99598006660	butyrate kinase; Provisional; Region: PRK03011
99598006661	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
99598006662	Calx-beta domain; Region: Calx-beta; cl02522
99598006663	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
99598006664	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879
99598006665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
99598006666	SdiA-regulated; Region: SdiA-regulated; cd09971
99598006667	putative active site [active]
99598006668	Lamin Tail Domain; Region: LTD; pfam00932
99598006669	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
99598006670	putative active site [active]
99598006671	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
99598006672	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
99598006673	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
99598006674	putative active site [active]
99598006675	catalytic site [active]
99598006676	putative metal binding site [ion binding]; other site
99598006677	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
99598006678	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
99598006679	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
99598006680	Phytase; Region: Phytase; cl17685
99598006681	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
99598006682	Survival protein SurE; Region: SurE; pfam01975
99598006683	Survival protein SurE; Region: SurE; pfam01975
99598006684	PhoD-like phosphatase; Region: PhoD; pfam09423
99598006685	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
99598006686	putative active site [active]
99598006687	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
99598006688	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
99598006689	Peptidase family A21; Region: Peptidase_A21; pfam03566
99598006690	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
99598006691	Lamin Tail Domain; Region: LTD; pfam00932
99598006692	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
99598006693	generic binding surface I; other site
99598006694	generic binding surface II; other site
99598006695	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
99598006696	putative active site [active]
99598006697	putative catalytic site [active]
99598006698	putative Mg binding site IVb [ion binding]; other site
99598006699	putative phosphate binding site [ion binding]; other site
99598006700	putative DNA binding site [nucleotide binding]; other site
99598006701	putative Mg binding site IVa [ion binding]; other site
99598006702	heat shock protein HtpX; Provisional; Region: PRK03982
99598006703	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598006704	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99598006705	putative substrate translocation pore; other site
99598006706	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
99598006707	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
99598006708	putative Cl- selectivity filter; other site
99598006709	putative pore gating glutamate residue; other site
99598006710	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
99598006711	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
99598006712	Walker A/P-loop; other site
99598006713	ATP binding site [chemical binding]; other site
99598006714	Q-loop/lid; other site
99598006715	ABC transporter signature motif; other site
99598006716	Walker B; other site
99598006717	D-loop; other site
99598006718	H-loop/switch region; other site
99598006719	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
99598006720	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
99598006721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598006722	dimer interface [polypeptide binding]; other site
99598006723	conserved gate region; other site
99598006724	putative PBP binding loops; other site
99598006725	ABC-ATPase subunit interface; other site
99598006726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598006727	dimer interface [polypeptide binding]; other site
99598006728	conserved gate region; other site
99598006729	putative PBP binding loops; other site
99598006730	ABC-ATPase subunit interface; other site
99598006731	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
99598006732	catalytic core [active]
99598006733	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
99598006734	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598006735	ATP binding site [chemical binding]; other site
99598006736	putative Mg++ binding site [ion binding]; other site
99598006737	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598006738	nucleotide binding region [chemical binding]; other site
99598006739	ATP-binding site [chemical binding]; other site
99598006740	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
99598006741	Protein of unknown function (DUF790); Region: DUF790; pfam05626
99598006742	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
99598006743	plasma-membrane calcium-translocating P-type ATPase; Region: ATPase-IIB_Ca; TIGR01517
99598006744	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99598006745	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99598006746	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
99598006747	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598006748	motif II; other site
99598006749	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
99598006750	Double zinc ribbon; Region: DZR; pfam12773
99598006751	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
99598006752	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
99598006753	active site
99598006754	active site
99598006755	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
99598006756	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
99598006757	putative metal binding site [ion binding]; other site
99598006758	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
99598006759	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
99598006760	putative metal binding site [ion binding]; other site
99598006761	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
99598006762	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
99598006763	cofactor binding site; other site
99598006764	DNA binding site [nucleotide binding]
99598006765	substrate interaction site [chemical binding]; other site
99598006766	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
99598006767	Bpu10I restriction endonuclease; Region: RE_Bpu10I; pfam09549
99598006768	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
99598006769	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
99598006770	active site
99598006771	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
99598006772	RuvA N terminal domain; Region: RuvA_N; pfam01330
99598006773	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
99598006774	sucrose-6F-phosphate phosphohydrolase; Region: SPP_plant-cyano; TIGR01485
99598006775	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598006776	Clp protease ATP binding subunit; Region: clpC; CHL00095
99598006777	Clp amino terminal domain; Region: Clp_N; pfam02861
99598006778	Clp amino terminal domain; Region: Clp_N; pfam02861
99598006779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598006780	Walker A motif; other site
99598006781	ATP binding site [chemical binding]; other site
99598006782	Walker B motif; other site
99598006783	arginine finger; other site
99598006784	UvrB/uvrC motif; Region: UVR; pfam02151
99598006785	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598006786	Walker A motif; other site
99598006787	ATP binding site [chemical binding]; other site
99598006788	Walker B motif; other site
99598006789	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
99598006790	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
99598006791	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598006792	Coenzyme A binding pocket [chemical binding]; other site
99598006793	diaminopimelate decarboxylase; Region: lysA; TIGR01048
99598006794	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
99598006795	active site
99598006796	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
99598006797	substrate binding site [chemical binding]; other site
99598006798	catalytic residues [active]
99598006799	dimer interface [polypeptide binding]; other site
99598006800	Uncharacterized conserved protein [Function unknown]; Region: COG1624
99598006801	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
99598006802	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
99598006803	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
99598006804	catalytic residue [active]
99598006805	putative FPP diphosphate  binding site; other site
99598006806	putative FPP binding hydrophobic cleft; other site
99598006807	dimer interface [polypeptide binding]; other site
99598006808	putative IPP diphosphate binding site; other site
99598006809	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
99598006810	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
99598006811	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99598006812	HSP70 interaction site [polypeptide binding]; other site
99598006813	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598006814	oligomeric interface; other site
99598006815	putative active site [active]
99598006816	homodimer interface [polypeptide binding]; other site
99598006817	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
99598006818	chaperone protein DnaJ; Provisional; Region: PRK14277
99598006819	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99598006820	HSP70 interaction site [polypeptide binding]; other site
99598006821	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
99598006822	substrate binding site [polypeptide binding]; other site
99598006823	dimer interface [polypeptide binding]; other site
99598006824	molecular chaperone DnaK; Provisional; Region: PRK13410
99598006825	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
99598006826	nucleotide binding site [chemical binding]; other site
99598006827	NEF interaction site [polypeptide binding]; other site
99598006828	SBD interface [polypeptide binding]; other site
99598006829	M28 Zn-Peptidases; Region: M28_like_1; cd05640
99598006830	Peptidase family M28; Region: Peptidase_M28; pfam04389
99598006831	metal binding site [ion binding]; metal-binding site
99598006832	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
99598006833	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
99598006834	Double zinc ribbon; Region: DZR; pfam12773
99598006835	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598006836	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598006837	active site
99598006838	ATP binding site [chemical binding]; other site
99598006839	substrate binding site [chemical binding]; other site
99598006840	activation loop (A-loop); other site
99598006841	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598006842	structural tetrad; other site
99598006843	PQQ-like domain; Region: PQQ_2; pfam13360
99598006844	Protein of unknown function (DUF561); Region: DUF561; pfam04481
99598006845	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
99598006846	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
99598006847	inhibitor-cofactor binding pocket; inhibition site
99598006848	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598006849	catalytic residue [active]
99598006850	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
99598006851	PemK-like protein; Region: PemK; pfam02452
99598006852	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
99598006853	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
99598006854	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
99598006855	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
99598006856	CoA-ligase; Region: Ligase_CoA; pfam00549
99598006857	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
99598006858	CoA binding domain; Region: CoA_binding; smart00881
99598006859	CoA-ligase; Region: Ligase_CoA; pfam00549
99598006860	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
99598006861	putative active site [active]
99598006862	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598006863	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598006864	binding surface
99598006865	TPR motif; other site
99598006866	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598006867	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
99598006868	DHH family; Region: DHH; pfam01368
99598006869	FOG: CBS domain [General function prediction only]; Region: COG0517
99598006870	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
99598006871	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
99598006872	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
99598006873	active site
99598006874	NTP binding site [chemical binding]; other site
99598006875	metal binding triad [ion binding]; metal-binding site
99598006876	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
99598006877	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
99598006878	photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576
99598006879	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
99598006880	homopentamer interface [polypeptide binding]; other site
99598006881	active site
99598006882	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
99598006883	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
99598006884	putative catalytic cysteine [active]
99598006885	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
99598006886	bile acid transporter; Region: bass; TIGR00841
99598006887	Sodium Bile acid symporter family; Region: SBF; cl17470
99598006888	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
99598006889	Sulfatase; Region: Sulfatase; pfam00884
99598006890	Uncharacterized conserved protein [Function unknown]; Region: COG1262
99598006891	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
99598006892	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598006893	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
99598006894	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
99598006895	putative di-iron ligands [ion binding]; other site
99598006896	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
99598006897	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
99598006898	putative di-iron ligands [ion binding]; other site
99598006899	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
99598006900	Fatty acid desaturase; Region: FA_desaturase; pfam00487
99598006901	Di-iron ligands [ion binding]; other site
99598006902	Aluminium resistance protein; Region: Alum_res; pfam06838
99598006903	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
99598006904	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
99598006905	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
99598006906	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
99598006907	TrkA-N domain; Region: TrkA_N; pfam02254
99598006908	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
99598006909	TrkA-N domain; Region: TrkA_N; pfam02254
99598006910	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
99598006911	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
99598006912	GUN4-like; Region: GUN4; pfam05419
99598006913	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
99598006914	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
99598006915	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
99598006916	YcfA-like protein; Region: YcfA; pfam07927
99598006917	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
99598006918	UbiA prenyltransferase family; Region: UbiA; pfam01040
99598006919	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
99598006920	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
99598006921	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
99598006922	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
99598006923	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
99598006924	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
99598006925	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
99598006926	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
99598006927	D-pathway; other site
99598006928	Putative ubiquinol binding site [chemical binding]; other site
99598006929	Low-spin heme (heme b) binding site [chemical binding]; other site
99598006930	Putative water exit pathway; other site
99598006931	Binuclear center (heme o3/CuB) [ion binding]; other site
99598006932	K-pathway; other site
99598006933	Putative proton exit pathway; other site
99598006934	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
99598006935	Subunit I/III interface [polypeptide binding]; other site
99598006936	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
99598006937	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
99598006938	P-loop; other site
99598006939	Magnesium ion binding site [ion binding]; other site
99598006940	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
99598006941	Magnesium ion binding site [ion binding]; other site
99598006942	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
99598006943	catalytic site [active]
99598006944	putative active site [active]
99598006945	putative substrate binding site [chemical binding]; other site
99598006946	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
99598006947	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
99598006948	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
99598006949	AAA ATPase domain; Region: AAA_16; pfam13191
99598006950	AAA domain; Region: AAA_22; pfam13401
99598006951	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598006952	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598006953	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
99598006954	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
99598006955	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
99598006956	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
99598006957	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
99598006958	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201
99598006959	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598006960	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
99598006961	ligand binding site [chemical binding]; other site
99598006962	flexible hinge region; other site
99598006963	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
99598006964	putative switch regulator; other site
99598006965	non-specific DNA interactions [nucleotide binding]; other site
99598006966	DNA binding site [nucleotide binding]
99598006967	sequence specific DNA binding site [nucleotide binding]; other site
99598006968	putative cAMP binding site [chemical binding]; other site
99598006969	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
99598006970	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
99598006971	NAD binding site [chemical binding]; other site
99598006972	homotetramer interface [polypeptide binding]; other site
99598006973	homodimer interface [polypeptide binding]; other site
99598006974	substrate binding site [chemical binding]; other site
99598006975	active site
99598006976	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
99598006977	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
99598006978	putative active site pocket [active]
99598006979	4-fold oligomerization interface [polypeptide binding]; other site
99598006980	metal binding residues [ion binding]; metal-binding site
99598006981	3-fold/trimer interface [polypeptide binding]; other site
99598006982	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
99598006983	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
99598006984	Walker A/P-loop; other site
99598006985	ATP binding site [chemical binding]; other site
99598006986	Q-loop/lid; other site
99598006987	ABC transporter signature motif; other site
99598006988	Walker B; other site
99598006989	D-loop; other site
99598006990	H-loop/switch region; other site
99598006991	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
99598006992	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
99598006993	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
99598006994	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
99598006995	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
99598006996	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
99598006997	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
99598006998	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
99598006999	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
99598007000	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
99598007001	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
99598007002	Galactose oxidase, central domain; Region: Kelch_3; cl02701
99598007003	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
99598007004	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
99598007005	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
99598007006	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
99598007007	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
99598007008	dihydropteroate synthase; Region: DHPS; TIGR01496
99598007009	substrate binding pocket [chemical binding]; other site
99598007010	dimer interface [polypeptide binding]; other site
99598007011	inhibitor binding site; inhibition site
99598007012	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
99598007013	dimer interface [polypeptide binding]; other site
99598007014	substrate binding site [chemical binding]; other site
99598007015	catalytic triad [active]
99598007016	Dynamin family; Region: Dynamin_N; pfam00350
99598007017	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
99598007018	G1 box; other site
99598007019	GTP/Mg2+ binding site [chemical binding]; other site
99598007020	Switch I region; other site
99598007021	G2 box; other site
99598007022	Switch II region; other site
99598007023	G3 box; other site
99598007024	G4 box; other site
99598007025	G5 box; other site
99598007026	Domain of unknown function (DUF697); Region: DUF697; pfam05128
99598007027	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
99598007028	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
99598007029	acyl-activating enzyme (AAE) consensus motif; other site
99598007030	AMP binding site [chemical binding]; other site
99598007031	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
99598007032	thioester reductase domain; Region: Thioester-redct; TIGR01746
99598007033	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
99598007034	putative NAD(P) binding site [chemical binding]; other site
99598007035	active site
99598007036	putative substrate binding site [chemical binding]; other site
99598007037	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598007038	active site
99598007039	ATP binding site [chemical binding]; other site
99598007040	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598007041	substrate binding site [chemical binding]; other site
99598007042	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
99598007043	substrate binding site [chemical binding]; other site
99598007044	activation loop (A-loop); other site
99598007045	activation loop (A-loop); other site
99598007046	AAA ATPase domain; Region: AAA_16; pfam13191
99598007047	Predicted ATPase [General function prediction only]; Region: COG3899
99598007048	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598007049	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598007050	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598007051	ATP binding site [chemical binding]; other site
99598007052	Mg2+ binding site [ion binding]; other site
99598007053	G-X-G motif; other site
99598007054	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
99598007055	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
99598007056	Conserved TM helix; Region: TM_helix; pfam05552
99598007057	Conserved TM helix; Region: TM_helix; pfam05552
99598007058	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
99598007059	hydrophobic ligand binding site; other site
99598007060	Uncharacterized conserved protein [Function unknown]; Region: COG2912
99598007061	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
99598007062	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598007063	binding surface
99598007064	TPR motif; other site
99598007065	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
99598007066	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
99598007067	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
99598007068	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
99598007069	alpha subunit interaction interface [polypeptide binding]; other site
99598007070	Walker A motif; other site
99598007071	ATP binding site [chemical binding]; other site
99598007072	Walker B motif; other site
99598007073	inhibitor binding site; inhibition site
99598007074	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
99598007075	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
99598007076	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
99598007077	gamma subunit interface [polypeptide binding]; other site
99598007078	epsilon subunit interface [polypeptide binding]; other site
99598007079	LBP interface [polypeptide binding]; other site
99598007080	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
99598007081	SPFH domain / Band 7 family; Region: Band_7; pfam01145
99598007082	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598007083	putative active site [active]
99598007084	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
99598007085	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598007086	active site
99598007087	ATP binding site [chemical binding]; other site
99598007088	substrate binding site [chemical binding]; other site
99598007089	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598007090	activation loop (A-loop); other site
99598007091	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598007092	structural tetrad; other site
99598007093	hypothetical protein; Provisional; Region: PRK02724
99598007094	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598007095	haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1
99598007096	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
99598007097	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
99598007098	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
99598007099	GDP-Fucose binding site [chemical binding]; other site
99598007100	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
99598007101	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
99598007102	active site
99598007103	TDP-binding site; other site
99598007104	acceptor substrate-binding pocket; other site
99598007105	homodimer interface [polypeptide binding]; other site
99598007106	TPR repeat; Region: TPR_11; pfam13414
99598007107	TPR repeat; Region: TPR_11; pfam13414
99598007108	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598007109	binding surface
99598007110	TPR motif; other site
99598007111	TPR repeat; Region: TPR_11; pfam13414
99598007112	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598007113	binding surface
99598007114	TPR motif; other site
99598007115	Ice-binding protein, left-handed beta-roll; Region: LbR_Ice_bind; cd12796
99598007116	putative water-binding motif; other site
99598007117	putative trimer interface [polypeptide binding]; other site
99598007118	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
99598007119	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598007120	Walker A motif; other site
99598007121	ATP binding site [chemical binding]; other site
99598007122	Walker B motif; other site
99598007123	arginine finger; other site
99598007124	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
99598007125	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
99598007126	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
99598007127	substrate binding site [chemical binding]; other site
99598007128	glutamase interaction surface [polypeptide binding]; other site
99598007129	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635
99598007130	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598007131	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99598007132	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598007133	DNA binding residues [nucleotide binding]
99598007134	dimerization interface [polypeptide binding]; other site
99598007135	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
99598007136	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
99598007137	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99598007138	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99598007139	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99598007140	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
99598007141	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
99598007142	iron-sulfur cluster [ion binding]; other site
99598007143	[2Fe-2S] cluster binding site [ion binding]; other site
99598007144	Uncharacterized conserved protein [Function unknown]; Region: COG3349
99598007145	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
99598007146	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
99598007147	nudix motif; other site
99598007148	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
99598007149	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
99598007150	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
99598007151	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
99598007152	homodimer interface [polypeptide binding]; other site
99598007153	NADP binding site [chemical binding]; other site
99598007154	substrate binding site [chemical binding]; other site
99598007155	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
99598007156	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
99598007157	substrate binding pocket [chemical binding]; other site
99598007158	chain length determination region; other site
99598007159	substrate-Mg2+ binding site; other site
99598007160	catalytic residues [active]
99598007161	aspartate-rich region 1; other site
99598007162	active site lid residues [active]
99598007163	aspartate-rich region 2; other site
99598007164	Divergent PAP2 family; Region: DUF212; pfam02681
99598007165	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
99598007166	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
99598007167	active site
99598007168	hydrophilic channel; other site
99598007169	dimerization interface [polypeptide binding]; other site
99598007170	catalytic residues [active]
99598007171	active site lid [active]
99598007172	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
99598007173	classical (c) SDRs; Region: SDR_c; cd05233
99598007174	NAD(P) binding site [chemical binding]; other site
99598007175	active site
99598007176	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
99598007177	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598007178	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
99598007179	dimer interface [polypeptide binding]; other site
99598007180	phosphorylation site [posttranslational modification]
99598007181	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598007182	ATP binding site [chemical binding]; other site
99598007183	Mg2+ binding site [ion binding]; other site
99598007184	G-X-G motif; other site
99598007185	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
99598007186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598007187	dimer interface [polypeptide binding]; other site
99598007188	conserved gate region; other site
99598007189	putative PBP binding loops; other site
99598007190	ABC-ATPase subunit interface; other site
99598007191	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
99598007192	NMT1-like family; Region: NMT1_2; pfam13379
99598007193	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
99598007194	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
99598007195	Walker A/P-loop; other site
99598007196	ATP binding site [chemical binding]; other site
99598007197	Q-loop/lid; other site
99598007198	ABC transporter signature motif; other site
99598007199	Walker B; other site
99598007200	D-loop; other site
99598007201	H-loop/switch region; other site
99598007202	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99598007203	Ligand Binding Site [chemical binding]; other site
99598007204	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
99598007205	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
99598007206	transmembrane helices; other site
99598007207	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
99598007208	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
99598007209	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
99598007210	CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558
99598007211	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
99598007212	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
99598007213	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
99598007214	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
99598007215	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
99598007216	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
99598007217	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
99598007218	active site
99598007219	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
99598007220	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
99598007221	putative active site [active]
99598007222	putative NTP binding site [chemical binding]; other site
99598007223	putative nucleic acid binding site [nucleotide binding]; other site
99598007224	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
99598007225	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
99598007226	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
99598007227	TPR motif; other site
99598007228	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598007229	binding surface
99598007230	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598007231	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598007232	binding surface
99598007233	TPR motif; other site
99598007234	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598007235	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598007236	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598007237	binding surface
99598007238	TPR motif; other site
99598007239	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598007240	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598007241	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598007242	binding surface
99598007243	TPR motif; other site
99598007244	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598007245	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598007246	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598007247	binding surface
99598007248	TPR motif; other site
99598007249	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598007250	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598007251	binding surface
99598007252	TPR motif; other site
99598007253	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598007254	CHAT domain; Region: CHAT; pfam12770
99598007255	Transmembrane protein; Region: Macoilin; pfam09726
99598007256	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
99598007257	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
99598007258	ligand binding site [chemical binding]; other site
99598007259	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
99598007260	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
99598007261	Rab subfamily motif 1 (RabSF1); other site
99598007262	G1 box; other site
99598007263	GTP/Mg2+ binding site [chemical binding]; other site
99598007264	Rab subfamily motif 2 (RabSF2); other site
99598007265	Switch I region; other site
99598007266	G2 box; other site
99598007267	effector interaction site; other site
99598007268	GDI interaction site; other site
99598007269	Rab family motif 1 (RabF1); other site
99598007270	GEF interaction site [polypeptide binding]; other site
99598007271	Rab family motif 2 (RabF2); other site
99598007272	G3 box; other site
99598007273	Switch II region; other site
99598007274	Rab family motif 3 (RabF3); other site
99598007275	Rab family motif 4 (RabF4); other site
99598007276	Rab family motif 5 (RabF5); other site
99598007277	Rab subfamily motif 3 (RabSF3); other site
99598007278	G4 box; other site
99598007279	G5 box; other site
99598007280	Rab subfamily motif 4 (RabSF4); other site
99598007281	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598007282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598007283	ATP binding site [chemical binding]; other site
99598007284	Mg2+ binding site [ion binding]; other site
99598007285	G-X-G motif; other site
99598007286	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598007287	primosomal protein N' Region: priA; TIGR00595
99598007288	ATP binding site [chemical binding]; other site
99598007289	putative Mg++ binding site [ion binding]; other site
99598007290	helicase superfamily c-terminal domain; Region: HELICc; smart00490
99598007291	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
99598007292	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
99598007293	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99598007294	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
99598007295	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99598007296	DNA binding residues [nucleotide binding]
99598007297	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
99598007298	EamA-like transporter family; Region: EamA; pfam00892
99598007299	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598007300	Coenzyme A binding pocket [chemical binding]; other site
99598007301	cytochrome c6; Provisional; Region: PRK13697
99598007302	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
99598007303	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
99598007304	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
99598007305	active site
99598007306	Na/Ca binding site [ion binding]; other site
99598007307	catalytic site [active]
99598007308	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
99598007309	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
99598007310	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
99598007311	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
99598007312	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
99598007313	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
99598007314	ATP binding site [chemical binding]; other site
99598007315	putative Mg++ binding site [ion binding]; other site
99598007316	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
99598007317	Dihaem cytochrome c; Region: DHC; pfam09626
99598007318	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
99598007319	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99598007320	Uncharacterized conserved protein [Function unknown]; Region: COG5464
99598007321	AMIN domain; Region: AMIN; pfam11741
99598007322	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
99598007323	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99598007324	N-terminal plug; other site
99598007325	ligand-binding site [chemical binding]; other site
99598007326	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
99598007327	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
99598007328	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
99598007329	MoxR-like ATPases [General function prediction only]; Region: COG0714
99598007330	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598007331	ATP binding site [chemical binding]; other site
99598007332	Walker A motif; other site
99598007333	Walker B motif; other site
99598007334	arginine finger; other site
99598007335	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
99598007336	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
99598007337	active site
99598007338	Riboflavin kinase; Region: Flavokinase; pfam01687
99598007339	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
99598007340	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
99598007341	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
99598007342	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
99598007343	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
99598007344	dimer interface [polypeptide binding]; other site
99598007345	motif 1; other site
99598007346	active site
99598007347	motif 2; other site
99598007348	motif 3; other site
99598007349	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598007350	putative active site [active]
99598007351	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598007352	putative active site [active]
99598007353	2-isopropylmalate synthase; Validated; Region: PRK00915
99598007354	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
99598007355	active site
99598007356	catalytic residues [active]
99598007357	metal binding site [ion binding]; metal-binding site
99598007358	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
99598007359	Uncharacterized conserved protein [Function unknown]; Region: COG1432
99598007360	LabA_like proteins; Region: LabA; cd10911
99598007361	putative metal binding site [ion binding]; other site
99598007362	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
99598007363	CHASE2 domain; Region: CHASE2; pfam05226
99598007364	Protein kinase domain; Region: Pkinase; pfam00069
99598007365	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598007366	active site
99598007367	ATP binding site [chemical binding]; other site
99598007368	substrate binding site [chemical binding]; other site
99598007369	activation loop (A-loop); other site
99598007370	PAS fold; Region: PAS_4; pfam08448
99598007371	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598007372	putative active site [active]
99598007373	heme pocket [chemical binding]; other site
99598007374	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598007375	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598007376	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598007377	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598007378	dimer interface [polypeptide binding]; other site
99598007379	phosphorylation site [posttranslational modification]
99598007380	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598007381	ATP binding site [chemical binding]; other site
99598007382	Mg2+ binding site [ion binding]; other site
99598007383	G-X-G motif; other site
99598007384	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
99598007385	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
99598007386	FAD binding domain; Region: FAD_binding_4; pfam01565
99598007387	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
99598007388	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598007389	putative active site [active]
99598007390	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
99598007391	active site
99598007392	catalytic triad [active]
99598007393	oxyanion hole [active]
99598007394	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
99598007395	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
99598007396	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
99598007397	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598007398	Mg2+ binding site [ion binding]; other site
99598007399	G-X-G motif; other site
99598007400	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
99598007401	anchoring element; other site
99598007402	dimer interface [polypeptide binding]; other site
99598007403	ATP binding site [chemical binding]; other site
99598007404	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
99598007405	active site
99598007406	putative metal-binding site [ion binding]; other site
99598007407	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
99598007408	ABC-2 type transporter; Region: ABC2_membrane; cl17235
99598007409	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
99598007410	ABC-2 type transporter; Region: ABC2_membrane; cl17235
99598007411	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
99598007412	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598007413	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
99598007414	Walker A/P-loop; other site
99598007415	ATP binding site [chemical binding]; other site
99598007416	Q-loop/lid; other site
99598007417	ABC transporter signature motif; other site
99598007418	Walker B; other site
99598007419	D-loop; other site
99598007420	H-loop/switch region; other site
99598007421	thioester reductase domain; Region: Thioester-redct; TIGR01746
99598007422	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
99598007423	putative NAD(P) binding site [chemical binding]; other site
99598007424	active site
99598007425	putative substrate binding site [chemical binding]; other site
99598007426	Condensation domain; Region: Condensation; pfam00668
99598007427	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
99598007428	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
99598007429	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
99598007430	acyl-activating enzyme (AAE) consensus motif; other site
99598007431	AMP binding site [chemical binding]; other site
99598007432	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
99598007433	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
99598007434	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
99598007435	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
99598007436	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
99598007437	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
99598007438	active site
99598007439	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
99598007440	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
99598007441	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
99598007442	putative NADP binding site [chemical binding]; other site
99598007443	active site
99598007444	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
99598007445	Condensation domain; Region: Condensation; pfam00668
99598007446	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
99598007447	Nonribosomal peptide synthase; Region: NRPS; pfam08415
99598007448	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
99598007449	CoA binding site [chemical binding]; other site
99598007450	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
99598007451	hypothetical protein; Validated; Region: PRK06840
99598007452	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
99598007453	dimer interface [polypeptide binding]; other site
99598007454	active site
99598007455	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
99598007456	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
99598007457	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
99598007458	active site
99598007459	Acyl transferase domain; Region: Acyl_transf_1; cl08282
99598007460	Acyl transferase domain; Region: Acyl_transf_1; cl08282
99598007461	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
99598007462	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
99598007463	acyl-activating enzyme (AAE) consensus motif; other site
99598007464	AMP binding site [chemical binding]; other site
99598007465	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
99598007466	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
99598007467	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
99598007468	Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843
99598007469	salicylate synthase; Region: salicyl_syn; TIGR03494
99598007470	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
99598007471	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
99598007472	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
99598007473	acyl-activating enzyme (AAE) consensus motif; other site
99598007474	AMP binding site [chemical binding]; other site
99598007475	active site
99598007476	CoA binding site [chemical binding]; other site
99598007477	Phosphopantetheine attachment site; Region: PP-binding; cl09936
99598007478	AMIN domain; Region: AMIN; pfam11741
99598007479	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
99598007480	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99598007481	N-terminal plug; other site
99598007482	ligand-binding site [chemical binding]; other site
99598007483	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
99598007484	putative dimer interface [polypeptide binding]; other site
99598007485	putative [2Fe-2S] cluster binding site [ion binding]; other site
99598007486	muropeptide transporter; Reviewed; Region: ampG; PRK11902
99598007487	muropeptide transporter; Validated; Region: ampG; cl17669
99598007488	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598007489	RNA polymerase sigma factor RpoD; Validated; Region: PRK07406
99598007490	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
99598007491	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99598007492	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
99598007493	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99598007494	DNA binding residues [nucleotide binding]
99598007495	light-harvesting-like protein 3; Provisional; Region: PLN00014
99598007496	DNA gyrase subunit A; Validated; Region: PRK05560
99598007497	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
99598007498	CAP-like domain; other site
99598007499	active site
99598007500	primary dimer interface [polypeptide binding]; other site
99598007501	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99598007502	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99598007503	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99598007504	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99598007505	Response regulator receiver domain; Region: Response_reg; pfam00072
99598007506	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598007507	active site
99598007508	phosphorylation site [posttranslational modification]
99598007509	intermolecular recognition site; other site
99598007510	dimerization interface [polypeptide binding]; other site
99598007511	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598007512	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598007513	binding surface
99598007514	TPR motif; other site
99598007515	TPR repeat; Region: TPR_11; pfam13414
99598007516	TPR repeat; Region: TPR_11; pfam13414
99598007517	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598007518	binding surface
99598007519	TPR motif; other site
99598007520	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99598007521	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99598007522	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
99598007523	dimer interface [polypeptide binding]; other site
99598007524	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
99598007525	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
99598007526	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
99598007527	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598007528	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
99598007529	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
99598007530	FtsX-like permease family; Region: FtsX; pfam02687
99598007531	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
99598007532	four helix bundle protein; Region: TIGR02436
99598007533	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
99598007534	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
99598007535	Walker A/P-loop; other site
99598007536	ATP binding site [chemical binding]; other site
99598007537	Q-loop/lid; other site
99598007538	ABC transporter signature motif; other site
99598007539	Walker B; other site
99598007540	D-loop; other site
99598007541	H-loop/switch region; other site
99598007542	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
99598007543	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
99598007544	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99598007545	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598007546	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
99598007547	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
99598007548	FtsX-like permease family; Region: FtsX; pfam02687
99598007549	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
99598007550	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
99598007551	Walker A/P-loop; other site
99598007552	ATP binding site [chemical binding]; other site
99598007553	Q-loop/lid; other site
99598007554	ABC transporter signature motif; other site
99598007555	Walker B; other site
99598007556	D-loop; other site
99598007557	H-loop/switch region; other site
99598007558	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
99598007559	RimM N-terminal domain; Region: RimM; pfam01782
99598007560	PRC-barrel domain; Region: PRC; pfam05239
99598007561	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
99598007562	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99598007563	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598007564	homodimer interface [polypeptide binding]; other site
99598007565	catalytic residue [active]
99598007566	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
99598007567	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
99598007568	substrate binding site [chemical binding]; other site
99598007569	catalytic Zn binding site [ion binding]; other site
99598007570	NAD binding site [chemical binding]; other site
99598007571	structural Zn binding site [ion binding]; other site
99598007572	dimer interface [polypeptide binding]; other site
99598007573	S-formylglutathione hydrolase; Region: PLN02442
99598007574	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
99598007575	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
99598007576	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
99598007577	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
99598007578	cofactor binding site; other site
99598007579	DNA binding site [nucleotide binding]
99598007580	substrate interaction site [chemical binding]; other site
99598007581	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
99598007582	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
99598007583	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
99598007584	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
99598007585	active site
99598007586	metal binding site [ion binding]; metal-binding site
99598007587	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
99598007588	Peptidase family M48; Region: Peptidase_M48; pfam01435
99598007589	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
99598007590	EamA-like transporter family; Region: EamA; pfam00892
99598007591	EamA-like transporter family; Region: EamA; pfam00892
99598007592	Electron transfer DM13; Region: DM13; pfam10517
99598007593	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598007594	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598007595	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598007596	dimer interface [polypeptide binding]; other site
99598007597	phosphorylation site [posttranslational modification]
99598007598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598007599	ATP binding site [chemical binding]; other site
99598007600	Mg2+ binding site [ion binding]; other site
99598007601	G-X-G motif; other site
99598007602	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
99598007603	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
99598007604	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
99598007605	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598007606	Walker A/P-loop; other site
99598007607	ATP binding site [chemical binding]; other site
99598007608	Q-loop/lid; other site
99598007609	ABC transporter signature motif; other site
99598007610	Walker B; other site
99598007611	D-loop; other site
99598007612	H-loop/switch region; other site
99598007613	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
99598007614	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
99598007615	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99598007616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598007617	active site
99598007618	phosphorylation site [posttranslational modification]
99598007619	intermolecular recognition site; other site
99598007620	dimerization interface [polypeptide binding]; other site
99598007621	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598007622	DNA binding residues [nucleotide binding]
99598007623	dimerization interface [polypeptide binding]; other site
99598007624	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598007625	active site
99598007626	phosphorylation site [posttranslational modification]
99598007627	intermolecular recognition site; other site
99598007628	dimerization interface [polypeptide binding]; other site
99598007629	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598007630	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598007631	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
99598007632	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
99598007633	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
99598007634	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
99598007635	ATP binding site [chemical binding]; other site
99598007636	Mg2+ binding site [ion binding]; other site
99598007637	G-X-G motif; other site
99598007638	Phosphotransferase enzyme family; Region: APH; pfam01636
99598007639	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
99598007640	active site
99598007641	ATP binding site [chemical binding]; other site
99598007642	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
99598007643	substrate binding site [chemical binding]; other site
99598007644	DDE superfamily endonuclease; Region: DDE_5; cl17874
99598007645	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
99598007646	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
99598007647	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
99598007648	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
99598007649	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
99598007650	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598007651	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
99598007652	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99598007653	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
99598007654	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
99598007655	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
99598007656	dimerization interface [polypeptide binding]; other site
99598007657	domain crossover interface; other site
99598007658	redox-dependent activation switch; other site
99598007659	Caspase domain; Region: Peptidase_C14; pfam00656
99598007660	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
99598007661	ATP-sulfurylase; Region: ATPS; cd00517
99598007662	active site
99598007663	HXXH motif; other site
99598007664	flexible loop; other site
99598007665	PQQ-like domain; Region: PQQ_2; pfam13360
99598007666	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
99598007667	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
99598007668	SNF2 Helicase protein; Region: DUF3670; pfam12419
99598007669	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598007670	ATP binding site [chemical binding]; other site
99598007671	putative Mg++ binding site [ion binding]; other site
99598007672	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598007673	nucleotide binding region [chemical binding]; other site
99598007674	ATP-binding site [chemical binding]; other site
99598007675	Uncharacterized conserved protein [Function unknown]; Region: COG4279
99598007676	SWIM zinc finger; Region: SWIM; pfam04434
99598007677	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
99598007678	L-aspartate oxidase; Provisional; Region: PRK06175
99598007679	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
99598007680	TIR domain; Region: TIR_2; pfam13676
99598007681	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
99598007682	aromatic arch; other site
99598007683	DCoH dimer interaction site [polypeptide binding]; other site
99598007684	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
99598007685	DCoH tetramer interaction site [polypeptide binding]; other site
99598007686	substrate binding site [chemical binding]; other site
99598007687	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
99598007688	hydrolase, alpha/beta fold family protein; Region: PLN02824
99598007689	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
99598007690	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598007691	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598007692	active site
99598007693	ATP binding site [chemical binding]; other site
99598007694	substrate binding site [chemical binding]; other site
99598007695	activation loop (A-loop); other site
99598007696	SnoaL-like domain; Region: SnoaL_2; pfam12680
99598007697	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
99598007698	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
99598007699	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
99598007700	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598007701	motif II; other site
99598007702	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
99598007703	putative phosphoketolase; Provisional; Region: PRK05261
99598007704	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
99598007705	TPP-binding site; other site
99598007706	XFP C-terminal domain; Region: XFP_C; pfam09363
99598007707	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
99598007708	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
99598007709	Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605
99598007710	flavodoxin FldA; Validated; Region: PRK09267
99598007711	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
99598007712	Photosystem II protein; Region: PSII; cl08223
99598007713	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
99598007714	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
99598007715	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
99598007716	transaldolase-like protein; Provisional; Region: PTZ00411
99598007717	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
99598007718	active site
99598007719	dimer interface [polypeptide binding]; other site
99598007720	catalytic residue [active]
99598007721	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
99598007722	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
99598007723	active site
99598007724	metal binding site [ion binding]; metal-binding site
99598007725	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
99598007726	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
99598007727	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598007728	non-specific DNA binding site [nucleotide binding]; other site
99598007729	salt bridge; other site
99598007730	sequence-specific DNA binding site [nucleotide binding]; other site
99598007731	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
99598007732	Part of AAA domain; Region: AAA_19; pfam13245
99598007733	Family description; Region: UvrD_C_2; pfam13538
99598007734	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598007735	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598007736	dimerization interface [polypeptide binding]; other site
99598007737	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598007738	dimer interface [polypeptide binding]; other site
99598007739	phosphorylation site [posttranslational modification]
99598007740	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598007741	ATP binding site [chemical binding]; other site
99598007742	Mg2+ binding site [ion binding]; other site
99598007743	G-X-G motif; other site
99598007744	S-adenosylmethionine synthetase; Validated; Region: PRK05250
99598007745	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
99598007746	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
99598007747	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
99598007748	phosphoribulokinase; Provisional; Region: PRK07429
99598007749	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
99598007750	active site
99598007751	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
99598007752	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
99598007753	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
99598007754	dimerization interface [polypeptide binding]; other site
99598007755	FAD binding pocket [chemical binding]; other site
99598007756	FAD binding motif [chemical binding]; other site
99598007757	catalytic residues [active]
99598007758	NAD binding pocket [chemical binding]; other site
99598007759	phosphate binding motif [ion binding]; other site
99598007760	beta-alpha-beta structure motif; other site
99598007761	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
99598007762	homoserine dehydrogenase; Provisional; Region: PRK06349
99598007763	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
99598007764	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
99598007765	Protein of unknown function (DUF497); Region: DUF497; pfam04365
99598007766	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
99598007767	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
99598007768	G1 box; other site
99598007769	putative GEF interaction site [polypeptide binding]; other site
99598007770	GTP/Mg2+ binding site [chemical binding]; other site
99598007771	Switch I region; other site
99598007772	G2 box; other site
99598007773	G3 box; other site
99598007774	Switch II region; other site
99598007775	G4 box; other site
99598007776	G5 box; other site
99598007777	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
99598007778	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
99598007779	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598007780	putative active site [active]
99598007781	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598007782	putative active site [active]
99598007783	S-layer homology domain; Region: SLH; pfam00395
99598007784	delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain); Region: D1pyr5carbox3; TIGR01238
99598007785	adaptive-response sensory kinase; Validated; Region: PRK09303
99598007786	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
99598007787	tetramer interface [polypeptide binding]; other site
99598007788	dimer interface [polypeptide binding]; other site
99598007789	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598007790	dimer interface [polypeptide binding]; other site
99598007791	phosphorylation site [posttranslational modification]
99598007792	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598007793	ATP binding site [chemical binding]; other site
99598007794	Mg2+ binding site [ion binding]; other site
99598007795	G-X-G motif; other site
99598007796	Response regulator receiver domain; Region: Response_reg; pfam00072
99598007797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598007798	active site
99598007799	phosphorylation site [posttranslational modification]
99598007800	intermolecular recognition site; other site
99598007801	dimerization interface [polypeptide binding]; other site
99598007802	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
99598007803	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99598007804	metal binding site [ion binding]; metal-binding site
99598007805	active site
99598007806	I-site; other site
99598007807	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
99598007808	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
99598007809	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598007810	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598007811	active site
99598007812	phosphorylation site [posttranslational modification]
99598007813	intermolecular recognition site; other site
99598007814	dimerization interface [polypeptide binding]; other site
99598007815	polyphosphate kinase; Provisional; Region: PRK05443
99598007816	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
99598007817	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
99598007818	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
99598007819	putative domain interface [polypeptide binding]; other site
99598007820	putative active site [active]
99598007821	catalytic site [active]
99598007822	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
99598007823	putative domain interface [polypeptide binding]; other site
99598007824	putative active site [active]
99598007825	catalytic site [active]
99598007826	Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050
99598007827	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
99598007828	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
99598007829	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
99598007830	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598007831	TPR motif; other site
99598007832	binding surface
99598007833	Methyltransferase domain; Region: Methyltransf_23; pfam13489
99598007834	Methyltransferase domain; Region: Methyltransf_11; pfam08241
99598007835	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
99598007836	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99598007837	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598007838	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
99598007839	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598007840	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598007841	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
99598007842	Ligand binding site; other site
99598007843	Putative Catalytic site; other site
99598007844	DXD motif; other site
99598007845	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598007846	dimer interface [polypeptide binding]; other site
99598007847	phosphorylation site [posttranslational modification]
99598007848	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598007849	ATP binding site [chemical binding]; other site
99598007850	Mg2+ binding site [ion binding]; other site
99598007851	G-X-G motif; other site
99598007852	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598007853	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598007854	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
99598007855	binding surface
99598007856	TPR motif; other site
99598007857	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
99598007858	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
99598007859	active site
99598007860	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598007861	TPR motif; other site
99598007862	binding surface
99598007863	CHAT domain; Region: CHAT; pfam12770
99598007864	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598007865	non-specific DNA binding site [nucleotide binding]; other site
99598007866	salt bridge; other site
99598007867	sequence-specific DNA binding site [nucleotide binding]; other site
99598007868	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
99598007869	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
99598007870	dimer interface [polypeptide binding]; other site
99598007871	putative anticodon binding site; other site
99598007872	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
99598007873	motif 1; other site
99598007874	active site
99598007875	motif 2; other site
99598007876	motif 3; other site
99598007877	KTSC domain; Region: KTSC; pfam13619
99598007878	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
99598007879	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
99598007880	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
99598007881	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
99598007882	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
99598007883	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598007884	TPR repeat; Region: TPR_11; pfam13414
99598007885	binding surface
99598007886	TPR motif; other site
99598007887	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598007888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
99598007889	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
99598007890	active site
99598007891	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598007892	putative active site [active]
99598007893	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
99598007894	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
99598007895	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
99598007896	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
99598007897	Predicted integral membrane protein [Function unknown]; Region: COG5542
99598007898	Predicted integral membrane protein [Function unknown]; Region: COG5542
99598007899	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
99598007900	Predicted membrane protein [Function unknown]; Region: COG3463
99598007901	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598007902	putative active site [active]
99598007903	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
99598007904	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
99598007905	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
99598007906	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
99598007907	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
99598007908	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
99598007909	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
99598007910	Ligand binding site; other site
99598007911	Putative Catalytic site; other site
99598007912	DXD motif; other site
99598007913	Uncharacterized protein family UPF0546; Region: UPF0546; pfam10639
99598007914	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
99598007915	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
99598007916	NodB motif; other site
99598007917	active site
99598007918	catalytic site [active]
99598007919	metal binding site [ion binding]; metal-binding site
99598007920	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
99598007921	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
99598007922	active site
99598007923	dimer interface [polypeptide binding]; other site
99598007924	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
99598007925	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
99598007926	active site
99598007927	FMN binding site [chemical binding]; other site
99598007928	substrate binding site [chemical binding]; other site
99598007929	3Fe-4S cluster binding site [ion binding]; other site
99598007930	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
99598007931	domain interface; other site
99598007932	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
99598007933	Cupin domain; Region: Cupin_2; cl17218
99598007934	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
99598007935	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
99598007936	S17 interaction site [polypeptide binding]; other site
99598007937	S8 interaction site; other site
99598007938	16S rRNA interaction site [nucleotide binding]; other site
99598007939	streptomycin interaction site [chemical binding]; other site
99598007940	23S rRNA interaction site [nucleotide binding]; other site
99598007941	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
99598007942	30S ribosomal protein S7; Validated; Region: PRK05302
99598007943	elongation factor G; Reviewed; Region: PRK00007
99598007944	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
99598007945	G1 box; other site
99598007946	putative GEF interaction site [polypeptide binding]; other site
99598007947	GTP/Mg2+ binding site [chemical binding]; other site
99598007948	Switch I region; other site
99598007949	G2 box; other site
99598007950	G3 box; other site
99598007951	Switch II region; other site
99598007952	G4 box; other site
99598007953	G5 box; other site
99598007954	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
99598007955	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
99598007956	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
99598007957	elongation factor Tu; Region: tufA; CHL00071
99598007958	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
99598007959	G1 box; other site
99598007960	GEF interaction site [polypeptide binding]; other site
99598007961	GTP/Mg2+ binding site [chemical binding]; other site
99598007962	Switch I region; other site
99598007963	G2 box; other site
99598007964	G3 box; other site
99598007965	Switch II region; other site
99598007966	G4 box; other site
99598007967	G5 box; other site
99598007968	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
99598007969	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
99598007970	Antibiotic Binding Site [chemical binding]; other site
99598007971	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
99598007972	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
99598007973	prephenate dehydratase; Provisional; Region: PRK11898
99598007974	Prephenate dehydratase; Region: PDT; pfam00800
99598007975	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
99598007976	putative L-Phe binding site [chemical binding]; other site
99598007977	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
99598007978	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
99598007979	RNA/DNA hybrid binding site [nucleotide binding]; other site
99598007980	active site
99598007981	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
99598007982	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
99598007983	homodimer interface [polypeptide binding]; other site
99598007984	oligonucleotide binding site [chemical binding]; other site
99598007985	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
99598007986	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
99598007987	B12 binding site [chemical binding]; other site
99598007988	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598007989	FeS/SAM binding site; other site
99598007990	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
99598007991	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
99598007992	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
99598007993	anti sigma factor interaction site; other site
99598007994	regulatory phosphorylation site [posttranslational modification]; other site
99598007995	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
99598007996	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99598007997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598007998	homodimer interface [polypeptide binding]; other site
99598007999	catalytic residue [active]
99598008000	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
99598008001	CAAX protease self-immunity; Region: Abi; pfam02517
99598008002	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
99598008003	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
99598008004	putative active site [active]
99598008005	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
99598008006	putative active site [active]
99598008007	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598008008	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598008009	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598008010	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598008011	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598008012	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
99598008013	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
99598008014	Zn2+ binding site [ion binding]; other site
99598008015	Mg2+ binding site [ion binding]; other site
99598008016	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
99598008017	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598008018	FeS/SAM binding site; other site
99598008019	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
99598008020	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
99598008021	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
99598008022	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
99598008023	Walker A/P-loop; other site
99598008024	ATP binding site [chemical binding]; other site
99598008025	Q-loop/lid; other site
99598008026	ABC transporter signature motif; other site
99598008027	Walker B; other site
99598008028	D-loop; other site
99598008029	H-loop/switch region; other site
99598008030	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99598008031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598008032	active site
99598008033	phosphorylation site [posttranslational modification]
99598008034	intermolecular recognition site; other site
99598008035	dimerization interface [polypeptide binding]; other site
99598008036	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99598008037	DNA binding site [nucleotide binding]
99598008038	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
99598008039	putative GSH binding site [chemical binding]; other site
99598008040	catalytic residues [active]
99598008041	BolA-like protein; Region: BolA; pfam01722
99598008042	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
99598008043	Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498
99598008044	active site
99598008045	catalytic triad [active]
99598008046	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
99598008047	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
99598008048	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
99598008049	putative acyl-acceptor binding pocket; other site
99598008050	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
99598008051	nucleoside/Zn binding site; other site
99598008052	dimer interface [polypeptide binding]; other site
99598008053	catalytic motif [active]
99598008054	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
99598008055	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
99598008056	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
99598008057	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
99598008058	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
99598008059	CRISPR/Cas system-associated protein Cas3; Distinct diverged subfamily of Cas3 helicase domain; Region: Cas3_I-D; cd09710
99598008060	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
99598008061	CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711
99598008062	CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159
99598008063	CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cd09709
99598008064	CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712
99598008065	WYL domain; Region: WYL; pfam13280
99598008066	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
99598008067	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
99598008068	ligand binding site; other site
99598008069	oligomer interface; other site
99598008070	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
99598008071	dimer interface [polypeptide binding]; other site
99598008072	N-terminal domain interface [polypeptide binding]; other site
99598008073	sulfate 1 binding site; other site
99598008074	AAA domain; Region: AAA_33; pfam13671
99598008075	L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575
99598008076	chaperone protein DnaJ; Provisional; Region: PRK14299
99598008077	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99598008078	HSP70 interaction site [polypeptide binding]; other site
99598008079	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
99598008080	substrate binding site [polypeptide binding]; other site
99598008081	dimer interface [polypeptide binding]; other site
99598008082	short chain dehydrogenase; Provisional; Region: PRK06172
99598008083	classical (c) SDRs; Region: SDR_c; cd05233
99598008084	NAD(P) binding site [chemical binding]; other site
99598008085	active site
99598008086	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
99598008087	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
99598008088	C-terminal domain interface [polypeptide binding]; other site
99598008089	GSH binding site (G-site) [chemical binding]; other site
99598008090	dimer interface [polypeptide binding]; other site
99598008091	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
99598008092	N-terminal domain interface [polypeptide binding]; other site
99598008093	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
99598008094	putative catalytic residues [active]
99598008095	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
99598008096	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
99598008097	dimer interface [polypeptide binding]; other site
99598008098	decamer (pentamer of dimers) interface [polypeptide binding]; other site
99598008099	catalytic triad [active]
99598008100	peroxidatic and resolving cysteines [active]
99598008101	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
99598008102	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
99598008103	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
99598008104	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
99598008105	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
99598008106	Peptidase family M23; Region: Peptidase_M23; pfam01551
99598008107	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
99598008108	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
99598008109	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598008110	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598008111	ligand binding site [chemical binding]; other site
99598008112	flexible hinge region; other site
99598008113	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598008114	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598008115	ligand binding site [chemical binding]; other site
99598008116	flexible hinge region; other site
99598008117	Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687
99598008118	substrate binding pocket [chemical binding]; other site
99598008119	substrate-Mg2+ binding site; other site
99598008120	aspartate-rich region 1; other site
99598008121	active site lid residues [active]
99598008122	aspartate-rich region 2; other site
99598008123	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
99598008124	substrate binding pocket [chemical binding]; other site
99598008125	substrate-Mg2+ binding site; other site
99598008126	aspartate-rich region 1; other site
99598008127	aspartate-rich region 2; other site
99598008128	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
99598008129	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598008130	Walker A motif; other site
99598008131	ATP binding site [chemical binding]; other site
99598008132	DNA helicase, putative; Region: TIGR00376
99598008133	AAA domain; Region: AAA_12; pfam13087
99598008134	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
99598008135	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
99598008136	putative active site [active]
99598008137	Zn binding site [ion binding]; other site
99598008138	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598008139	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
99598008140	Mechanosensitive ion channel; Region: MS_channel; pfam00924
99598008141	S-layer homology domain; Region: SLH; pfam00395
99598008142	S-layer homology domain; Region: SLH; pfam00395
99598008143	S-layer homology domain; Region: SLH; pfam00395
99598008144	Predicted membrane protein [Function unknown]; Region: COG2119
99598008145	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
99598008146	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
99598008147	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598008148	TPR motif; other site
99598008149	binding surface
99598008150	TPR repeat; Region: TPR_11; pfam13414
99598008151	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598008152	binding surface
99598008153	TPR motif; other site
99598008154	Domain of unknown function DUF39; Region: DUF39; pfam01837
99598008155	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
99598008156	active site
99598008157	catalytic residues [active]
99598008158	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
99598008159	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
99598008160	active site
99598008161	homodimer interface [polypeptide binding]; other site
99598008162	catalytic site [active]
99598008163	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
99598008164	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
99598008165	Fasciclin domain; Region: Fasciclin; pfam02469
99598008166	DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191
99598008167	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
99598008168	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
99598008169	putative ligand binding site [chemical binding]; other site
99598008170	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
99598008171	feedback inhibition sensing region; other site
99598008172	homohexameric interface [polypeptide binding]; other site
99598008173	nucleotide binding site [chemical binding]; other site
99598008174	N-acetyl-L-glutamate binding site [chemical binding]; other site
99598008175	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598008176	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
99598008177	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
99598008178	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
99598008179	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
99598008180	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
99598008181	Domain of unknown function DUF20; Region: UPF0118; pfam01594
99598008182	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
99598008183	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
99598008184	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
99598008185	active site
99598008186	Substrate binding site; other site
99598008187	Mg++ binding site; other site
99598008188	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
99598008189	putative trimer interface [polypeptide binding]; other site
99598008190	putative CoA binding site [chemical binding]; other site
99598008191	arginine decarboxylase; Provisional; Region: PRK05354
99598008192	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
99598008193	dimer interface [polypeptide binding]; other site
99598008194	active site
99598008195	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
99598008196	catalytic residues [active]
99598008197	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
99598008198	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
99598008199	active site
99598008200	multimer interface [polypeptide binding]; other site
99598008201	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
99598008202	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
99598008203	active site
99598008204	metal binding site [ion binding]; metal-binding site
99598008205	shikimate kinase; Reviewed; Region: aroK; PRK00131
99598008206	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
99598008207	ADP binding site [chemical binding]; other site
99598008208	magnesium binding site [ion binding]; other site
99598008209	putative shikimate binding site; other site
99598008210	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
99598008211	aromatic acid decarboxylase; Validated; Region: PRK05920
99598008212	Flavoprotein; Region: Flavoprotein; pfam02441
99598008213	Exoribonuclease R [Transcription]; Region: VacB; COG0557
99598008214	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
99598008215	RNB domain; Region: RNB; pfam00773
99598008216	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
99598008217	RNA binding site [nucleotide binding]; other site
99598008218	Clp protease; Region: CLP_protease; pfam00574
99598008219	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
99598008220	oligomer interface [polypeptide binding]; other site
99598008221	active site residues [active]
99598008222	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
99598008223	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
99598008224	catalytic residues [active]
99598008225	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
99598008226	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
99598008227	GTP binding site; other site
99598008228	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
99598008229	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
99598008230	putative ligand binding site [chemical binding]; other site
99598008231	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598008232	TPR repeat; Region: TPR_11; pfam13414
99598008233	binding surface
99598008234	TPR motif; other site
99598008235	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
99598008236	Ferritin-like domain; Region: Ferritin; pfam00210
99598008237	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
99598008238	dinuclear metal binding motif [ion binding]; other site
99598008239	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
99598008240	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
99598008241	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
99598008242	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
99598008243	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
99598008244	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310
99598008245	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
99598008246	PDGLE domain; Region: PDGLE; pfam13190
99598008247	Cobalt transport protein; Region: CbiQ; cl00463
99598008248	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
99598008249	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
99598008250	Walker A/P-loop; other site
99598008251	ATP binding site [chemical binding]; other site
99598008252	Q-loop/lid; other site
99598008253	ABC transporter signature motif; other site
99598008254	Walker B; other site
99598008255	D-loop; other site
99598008256	H-loop/switch region; other site
99598008257	S-layer homology domain; Region: SLH; pfam00395
99598008258	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
99598008259	Predicted membrane protein [Function unknown]; Region: COG4330
99598008260	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
99598008261	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598008262	S-adenosylmethionine binding site [chemical binding]; other site
99598008263	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99598008264	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598008265	DNA binding residues [nucleotide binding]
99598008266	S-layer homology domain; Region: SLH; pfam00395
99598008267	S-layer homology domain; Region: SLH; pfam00395
99598008268	KWG Leptospira; Region: KWG; pfam07656
99598008269	KWG Leptospira; Region: KWG; pfam07656
99598008270	KWG Leptospira; Region: KWG; pfam07656
99598008271	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
99598008272	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598008273	FeS/SAM binding site; other site
99598008274	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598008275	putative active site [active]
99598008276	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
99598008277	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
99598008278	HflX GTPase family; Region: HflX; cd01878
99598008279	G1 box; other site
99598008280	GTP/Mg2+ binding site [chemical binding]; other site
99598008281	Switch I region; other site
99598008282	G2 box; other site
99598008283	G3 box; other site
99598008284	Switch II region; other site
99598008285	G4 box; other site
99598008286	G5 box; other site
99598008287	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
99598008288	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
99598008289	putative sugar binding sites [chemical binding]; other site
99598008290	Q-X-W motif; other site
99598008291	aspartate aminotransferase; Provisional; Region: PRK05957
99598008292	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99598008293	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598008294	homodimer interface [polypeptide binding]; other site
99598008295	catalytic residue [active]
99598008296	Uncharacterized conserved protein [Function unknown]; Region: COG0432
99598008297	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
99598008298	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
99598008299	[2Fe-2S] cluster binding site [ion binding]; other site
99598008300	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
99598008301	hydrophobic ligand binding site; other site
99598008302	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
99598008303	NADH(P)-binding; Region: NAD_binding_10; pfam13460
99598008304	NAD(P) binding site [chemical binding]; other site
99598008305	putative active site [active]
99598008306	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
99598008307	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598008308	structural tetrad; other site
99598008309	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598008310	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598008311	putative active site [active]
99598008312	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598008313	putative active site [active]
99598008314	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
99598008315	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598008316	putative active site [active]
99598008317	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
99598008318	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598008319	Walker A motif; other site
99598008320	ATP binding site [chemical binding]; other site
99598008321	Walker B motif; other site
99598008322	arginine finger; other site
99598008323	Peptidase family M41; Region: Peptidase_M41; pfam01434
99598008324	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
99598008325	Domain of unknown function DUF20; Region: UPF0118; pfam01594
99598008326	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
99598008327	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
99598008328	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
99598008329	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
99598008330	Peptidase family M48; Region: Peptidase_M48; cl12018
99598008331	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
99598008332	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
99598008333	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
99598008334	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
99598008335	catalytic site [active]
99598008336	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
99598008337	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598008338	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
99598008339	S-layer homology domain; Region: SLH; pfam00395
99598008340	S-layer homology domain; Region: SLH; pfam00395
99598008341	S-layer homology domain; Region: SLH; pfam00395
99598008342	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
99598008343	GIY-YIG motif/motif A; other site
99598008344	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
99598008345	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
99598008346	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
99598008347	DXD motif; other site
99598008348	PilZ domain; Region: PilZ; pfam07238
99598008349	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
99598008350	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
99598008351	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598008352	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598008353	binding surface
99598008354	TPR motif; other site
99598008355	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
99598008356	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598008357	TPR motif; other site
99598008358	binding surface
99598008359	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
99598008360	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
99598008361	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
99598008362	Cellulose binding domain; Region: CBM_2; pfam00553
99598008363	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
99598008364	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
99598008365	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
99598008366	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
99598008367	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
99598008368	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
99598008369	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
99598008370	DNA binding site [nucleotide binding]
99598008371	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
99598008372	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
99598008373	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
99598008374	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
99598008375	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
99598008376	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
99598008377	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
99598008378	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
99598008379	RPB1 interaction site [polypeptide binding]; other site
99598008380	RPB10 interaction site [polypeptide binding]; other site
99598008381	RPB11 interaction site [polypeptide binding]; other site
99598008382	RPB3 interaction site [polypeptide binding]; other site
99598008383	RPB12 interaction site [polypeptide binding]; other site
99598008384	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
99598008385	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
99598008386	active site
99598008387	ribosomal protein S20; Region: rps20; CHL00102
99598008388	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
99598008389	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
99598008390	NAD binding site [chemical binding]; other site
99598008391	dimerization interface [polypeptide binding]; other site
99598008392	product binding site; other site
99598008393	substrate binding site [chemical binding]; other site
99598008394	zinc binding site [ion binding]; other site
99598008395	catalytic residues [active]
99598008396	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99598008397	Ligand Binding Site [chemical binding]; other site
99598008398	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432
99598008399	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
99598008400	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
99598008401	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99598008402	catalytic residue [active]
99598008403	molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762
99598008404	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598008405	oligomeric interface; other site
99598008406	putative active site [active]
99598008407	homodimer interface [polypeptide binding]; other site
99598008408	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598008409	ATP binding site [chemical binding]; other site
99598008410	Mg2+ binding site [ion binding]; other site
99598008411	G-X-G motif; other site
99598008412	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
99598008413	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598008414	ATP binding site [chemical binding]; other site
99598008415	putative Mg++ binding site [ion binding]; other site
99598008416	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598008417	nucleotide binding region [chemical binding]; other site
99598008418	ATP-binding site [chemical binding]; other site
99598008419	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
99598008420	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
99598008421	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
99598008422	lipoyl synthase; Provisional; Region: PRK05481
99598008423	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
99598008424	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
99598008425	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
99598008426	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
99598008427	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
99598008428	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99598008429	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
99598008430	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99598008431	DNA binding residues [nucleotide binding]
99598008432	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
99598008433	metal binding site 2 [ion binding]; metal-binding site
99598008434	putative DNA binding helix; other site
99598008435	metal binding site 1 [ion binding]; metal-binding site
99598008436	dimer interface [polypeptide binding]; other site
99598008437	structural Zn2+ binding site [ion binding]; other site
99598008438	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
99598008439	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598008440	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
99598008441	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598008442	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598008443	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598008444	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598008445	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598008446	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598008447	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598008448	dimer interface [polypeptide binding]; other site
99598008449	phosphorylation site [posttranslational modification]
99598008450	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598008451	ATP binding site [chemical binding]; other site
99598008452	Mg2+ binding site [ion binding]; other site
99598008453	G-X-G motif; other site
99598008454	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
99598008455	propionate/acetate kinase; Provisional; Region: PRK12379
99598008456	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
99598008457	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
99598008458	homodimer interface [polypeptide binding]; other site
99598008459	substrate-cofactor binding pocket; other site
99598008460	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598008461	catalytic residue [active]
99598008462	FtsH Extracellular; Region: FtsH_ext; pfam06480
99598008463	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
99598008464	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598008465	Walker A motif; other site
99598008466	ATP binding site [chemical binding]; other site
99598008467	Walker B motif; other site
99598008468	arginine finger; other site
99598008469	Peptidase family M41; Region: Peptidase_M41; pfam01434
99598008470	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
99598008471	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
99598008472	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
99598008473	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
99598008474	Cl- selectivity filter; other site
99598008475	Cl- binding residues [ion binding]; other site
99598008476	pore gating glutamate residue; other site
99598008477	dimer interface [polypeptide binding]; other site
99598008478	H+/Cl- coupling transport residue; other site
99598008479	FOG: CBS domain [General function prediction only]; Region: COG0517
99598008480	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
99598008481	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
99598008482	Ligand Binding Site [chemical binding]; other site
99598008483	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99598008484	Ligand Binding Site [chemical binding]; other site
99598008485	DDE superfamily endonuclease; Region: DDE_5; cl17874
99598008486	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
99598008487	TIR domain; Region: TIR_2; pfam13676
99598008488	GUN4-like; Region: GUN4; pfam05419
99598008489	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
99598008490	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598008491	active site
99598008492	ATP binding site [chemical binding]; other site
99598008493	substrate binding site [chemical binding]; other site
99598008494	activation loop (A-loop); other site
99598008495	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598008496	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598008497	structural tetrad; other site
99598008498	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
99598008499	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
99598008500	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
99598008501	PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990
99598008502	protein binding site [polypeptide binding]; other site
99598008503	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598008504	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598008505	ligand binding site [chemical binding]; other site
99598008506	flexible hinge region; other site
99598008507	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
99598008508	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
99598008509	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
99598008510	Hexamer interface [polypeptide binding]; other site
99598008511	Hexagonal pore residue; other site
99598008512	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
99598008513	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
99598008514	Hexamer interface [polypeptide binding]; other site
99598008515	Hexagonal pore residue; other site
99598008516	Uncharacterized conserved protein [Function unknown]; Region: COG0062
99598008517	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
99598008518	putative substrate binding site [chemical binding]; other site
99598008519	putative ATP binding site [chemical binding]; other site
99598008520	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
99598008521	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
99598008522	Integral membrane protein TerC family; Region: TerC; pfam03741
99598008523	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598008524	Coenzyme A binding pocket [chemical binding]; other site
99598008525	acetyl-CoA synthetase; Provisional; Region: PRK00174
99598008526	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
99598008527	active site
99598008528	CoA binding site [chemical binding]; other site
99598008529	acyl-activating enzyme (AAE) consensus motif; other site
99598008530	AMP binding site [chemical binding]; other site
99598008531	acetate binding site [chemical binding]; other site
99598008532	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598008533	binding surface
99598008534	TPR motif; other site
99598008535	TPR repeat; Region: TPR_11; pfam13414
99598008536	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598008537	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
99598008538	Putative restriction endonuclease; Region: Uma2; pfam05685
99598008539	putative active site [active]
99598008540	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
99598008541	MarR family; Region: MarR; pfam01047
99598008542	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
99598008543	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
99598008544	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598008545	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
99598008546	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
99598008547	catalytic residue [active]
99598008548	putative FPP diphosphate  binding site; other site
99598008549	putative FPP binding hydrophobic cleft; other site
99598008550	dimer interface [polypeptide binding]; other site
99598008551	putative IPP diphosphate binding site; other site
99598008552	AAA ATPase domain; Region: AAA_16; pfam13191
99598008553	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598008554	TPR motif; other site
99598008555	binding surface
99598008556	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598008557	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
99598008558	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
99598008559	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
99598008560	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
99598008561	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
99598008562	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
99598008563	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
99598008564	active site
99598008565	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
99598008566	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
99598008567	substrate binding site [chemical binding]; other site
99598008568	ATP binding site [chemical binding]; other site
99598008569	Predicted methyltransferases [General function prediction only]; Region: COG0313
99598008570	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
99598008571	putative SAM binding site [chemical binding]; other site
99598008572	putative homodimer interface [polypeptide binding]; other site
99598008573	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
99598008574	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
99598008575	putative active site [active]
99598008576	catalytic residue [active]
99598008577	twin arginine translocase protein A; Provisional; Region: tatA; PRK14857
99598008578	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
99598008579	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
99598008580	Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468
99598008581	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
99598008582	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
99598008583	active site
99598008584	catalytic site [active]
99598008585	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
99598008586	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
99598008587	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
99598008588	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598008589	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
99598008590	Walker A motif; other site
99598008591	ATP binding site [chemical binding]; other site
99598008592	Walker B motif; other site
99598008593	arginine finger; other site
99598008594	Protein of unknown function (DUF497); Region: DUF497; cl01108
99598008595	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
99598008596	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
99598008597	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
99598008598	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
99598008599	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
99598008600	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
99598008601	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
99598008602	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
99598008603	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
99598008604	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
99598008605	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
99598008606	Phage protein D [General function prediction only]; Region: COG3500
99598008607	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
99598008608	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
99598008609	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
99598008610	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
99598008611	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
99598008612	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
99598008613	phage tail protein domain; Region: tail_TIGR02242
99598008614	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
99598008615	Transposase [DNA replication, recombination, and repair]; Region: COG5421
99598008616	short chain dehydrogenase; Validated; Region: PRK06182
99598008617	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99598008618	NAD(P) binding site [chemical binding]; other site
99598008619	active site
99598008620	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99598008621	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
99598008622	active site
99598008623	catalytic tetrad [active]
99598008624	Predicted GTPase [General function prediction only]; Region: COG3596
99598008625	YfjP GTPase; Region: YfjP; cd11383
99598008626	G1 box; other site
99598008627	GTP/Mg2+ binding site [chemical binding]; other site
99598008628	Switch I region; other site
99598008629	G2 box; other site
99598008630	Switch II region; other site
99598008631	G3 box; other site
99598008632	G4 box; other site
99598008633	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
99598008634	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
99598008635	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
99598008636	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
99598008637	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
99598008638	[2Fe-2S] cluster binding site [ion binding]; other site
99598008639	oxidoreductase, 2OG-Fe(II) oxygenase family protein; Region: PLN02984
99598008640	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
99598008641	Methyltransferase domain; Region: Methyltransf_26; pfam13659
99598008642	Pirin-related protein [General function prediction only]; Region: COG1741
99598008643	Pirin; Region: Pirin; pfam02678
99598008644	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
99598008645	Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751
99598008646	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
99598008647	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
99598008648	trmE is a tRNA modification GTPase; Region: trmE; cd04164
99598008649	G1 box; other site
99598008650	GTP/Mg2+ binding site [chemical binding]; other site
99598008651	Switch I region; other site
99598008652	G2 box; other site
99598008653	Switch II region; other site
99598008654	G3 box; other site
99598008655	G4 box; other site
99598008656	G5 box; other site
99598008657	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
99598008658	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
99598008659	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598008660	Coenzyme A binding pocket [chemical binding]; other site
99598008661	C factor cell-cell signaling protein; Provisional; Region: PRK09009
99598008662	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
99598008663	NADP binding site [chemical binding]; other site
99598008664	homodimer interface [polypeptide binding]; other site
99598008665	active site
99598008666	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
99598008667	G1 box; other site
99598008668	GTP/Mg2+ binding site [chemical binding]; other site
99598008669	G2 box; other site
99598008670	Switch I region; other site
99598008671	G3 box; other site
99598008672	Switch II region; other site
99598008673	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
99598008674	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
99598008675	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
99598008676	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
99598008677	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
99598008678	trimer interface [polypeptide binding]; other site
99598008679	active site
99598008680	substrate binding site [chemical binding]; other site
99598008681	CoA binding site [chemical binding]; other site
99598008682	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
99598008683	Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528
99598008684	active site residue [active]
99598008685	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
99598008686	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
99598008687	putative di-iron ligands [ion binding]; other site
99598008688	CHAT domain; Region: CHAT; pfam12770
99598008689	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
99598008690	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
99598008691	Transposase [DNA replication, recombination, and repair]; Region: COG5433
99598008692	Transposase [DNA replication, recombination, and repair]; Region: COG5433
99598008693	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
99598008694	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
99598008695	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598008696	Coenzyme A binding pocket [chemical binding]; other site
99598008697	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
99598008698	DHH family; Region: DHH; pfam01368
99598008699	DHHA1 domain; Region: DHHA1; pfam02272
99598008700	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598008701	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
99598008702	putative ADP-binding pocket [chemical binding]; other site
99598008703	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
99598008704	putative catalytic site [active]
99598008705	putative phosphate binding site [ion binding]; other site
99598008706	active site
99598008707	metal binding site A [ion binding]; metal-binding site
99598008708	DNA binding site [nucleotide binding]
99598008709	putative AP binding site [nucleotide binding]; other site
99598008710	putative metal binding site B [ion binding]; other site
99598008711	multifunctional aminopeptidase A; Provisional; Region: PRK00913
99598008712	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
99598008713	interface (dimer of trimers) [polypeptide binding]; other site
99598008714	Substrate-binding/catalytic site; other site
99598008715	Zn-binding sites [ion binding]; other site
99598008716	putative phosphate acyltransferase; Provisional; Region: PRK05331
99598008717	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
99598008718	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
99598008719	dimer interface [polypeptide binding]; other site
99598008720	active site
99598008721	CoA binding pocket [chemical binding]; other site
99598008722	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
99598008723	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
99598008724	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
99598008725	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
99598008726	putative acyl-acceptor binding pocket; other site
99598008727	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
99598008728	Domain of unknown function DUF20; Region: UPF0118; pfam01594
99598008729	Uncharacterized small conserved protein [Function unknown]; Region: COG5626
99598008730	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
99598008731	Amidase; Region: Amidase; pfam01425
99598008732	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99598008733	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99598008734	WHG domain; Region: WHG; pfam13305
99598008735	Uncharacterized conserved protein [Function unknown]; Region: COG1434
99598008736	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
99598008737	putative active site [active]
99598008738	LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161
99598008739	Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249
99598008740	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
99598008741	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
99598008742	NADP binding site [chemical binding]; other site
99598008743	substrate binding site [chemical binding]; other site
99598008744	active site
99598008745	Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131
99598008746	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
99598008747	NAD binding site [chemical binding]; other site
99598008748	catalytic residues [active]
99598008749	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598008750	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598008751	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598008752	dimer interface [polypeptide binding]; other site
99598008753	phosphorylation site [posttranslational modification]
99598008754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598008755	ATP binding site [chemical binding]; other site
99598008756	Mg2+ binding site [ion binding]; other site
99598008757	G-X-G motif; other site
99598008758	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
99598008759	classical (c) SDRs; Region: SDR_c; cd05233
99598008760	NAD(P) binding site [chemical binding]; other site
99598008761	active site
99598008762	Protein kinase domain; Region: Pkinase; pfam00069
99598008763	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598008764	active site
99598008765	ATP binding site [chemical binding]; other site
99598008766	substrate binding site [chemical binding]; other site
99598008767	activation loop (A-loop); other site
99598008768	AAA ATPase domain; Region: AAA_16; pfam13191
99598008769	Predicted ATPase [General function prediction only]; Region: COG3899
99598008770	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598008771	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598008772	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598008773	heme pocket [chemical binding]; other site
99598008774	putative active site [active]
99598008775	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598008776	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598008777	ATP binding site [chemical binding]; other site
99598008778	Mg2+ binding site [ion binding]; other site
99598008779	G-X-G motif; other site
99598008780	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598008781	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598008782	active site
99598008783	ATP binding site [chemical binding]; other site
99598008784	substrate binding site [chemical binding]; other site
99598008785	activation loop (A-loop); other site
99598008786	AAA ATPase domain; Region: AAA_16; pfam13191
99598008787	Predicted ATPase [General function prediction only]; Region: COG3899
99598008788	Walker A motif; other site
99598008789	ATP binding site [chemical binding]; other site
99598008790	Walker B motif; other site
99598008791	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598008792	GAF domain; Region: GAF; pfam01590
99598008793	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598008794	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598008795	ATP binding site [chemical binding]; other site
99598008796	Mg2+ binding site [ion binding]; other site
99598008797	G-X-G motif; other site
99598008798	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
99598008799	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
99598008800	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
99598008801	active site
99598008802	catalytic triad [active]
99598008803	oxyanion hole [active]
99598008804	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
99598008805	hypothetical protein; Provisional; Region: PRK02237
99598008806	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
99598008807	AIR carboxylase; Region: AIRC; pfam00731
99598008808	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
99598008809	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
99598008810	active site
99598008811	dimer interface [polypeptide binding]; other site
99598008812	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
99598008813	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
99598008814	active site
99598008815	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
99598008816	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
99598008817	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
99598008818	GTP/Mg2+ binding site [chemical binding]; other site
99598008819	G4 box; other site
99598008820	G5 box; other site
99598008821	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
99598008822	G1 box; other site
99598008823	G1 box; other site
99598008824	GTP/Mg2+ binding site [chemical binding]; other site
99598008825	Switch I region; other site
99598008826	Switch I region; other site
99598008827	G2 box; other site
99598008828	G3 box; other site
99598008829	G3 box; other site
99598008830	Switch II region; other site
99598008831	Switch II region; other site
99598008832	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
99598008833	B1 nucleotide binding pocket [chemical binding]; other site
99598008834	B2 nucleotide binding pocket [chemical binding]; other site
99598008835	CAS motifs; other site
99598008836	active site
99598008837	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598008838	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
99598008839	G1 box; other site
99598008840	GTP/Mg2+ binding site [chemical binding]; other site
99598008841	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598008842	structural tetrad; other site
99598008843	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
99598008844	WD domain, G-beta repeat; Region: WD40; pfam00400
99598008845	WD40 repeats; Region: WD40; smart00320
99598008846	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598008847	binding surface
99598008848	TPR motif; other site
99598008849	TPR repeat; Region: TPR_11; pfam13414
99598008850	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598008851	TPR motif; other site
99598008852	binding surface
99598008853	Tetratricopeptide repeat; Region: TPR_9; pfam13371
99598008854	Archaeal ATPase; Region: Arch_ATPase; pfam01637
99598008855	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
99598008856	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
99598008857	phosphopeptide binding site; other site
99598008858	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598008859	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598008860	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
99598008861	cyclase homology domain; Region: CHD; cd07302
99598008862	nucleotidyl binding site; other site
99598008863	metal binding site [ion binding]; metal-binding site
99598008864	dimer interface [polypeptide binding]; other site
99598008865	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
99598008866	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
99598008867	NAD(P) binding site [chemical binding]; other site
99598008868	catalytic residues [active]
99598008869	acetolactate synthase; Reviewed; Region: PRK08322
99598008870	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
99598008871	PYR/PP interface [polypeptide binding]; other site
99598008872	dimer interface [polypeptide binding]; other site
99598008873	TPP binding site [chemical binding]; other site
99598008874	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
99598008875	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
99598008876	TPP-binding site [chemical binding]; other site
99598008877	dimer interface [polypeptide binding]; other site
99598008878	hypothetical protein; Validated; Region: PRK07411
99598008879	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
99598008880	ATP binding site [chemical binding]; other site
99598008881	substrate interface [chemical binding]; other site
99598008882	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
99598008883	active site residue [active]
99598008884	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
99598008885	MPN+ (JAMM) motif; other site
99598008886	Zinc-binding site [ion binding]; other site
99598008887	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
99598008888	four helix bundle protein; Region: TIGR02436
99598008889	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
99598008890	active site clefts [active]
99598008891	zinc binding site [ion binding]; other site
99598008892	dimer interface [polypeptide binding]; other site
99598008893	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
99598008894	active site clefts [active]
99598008895	zinc binding site [ion binding]; other site
99598008896	dimer interface [polypeptide binding]; other site
99598008897	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
99598008898	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
99598008899	Walker A/P-loop; other site
99598008900	ATP binding site [chemical binding]; other site
99598008901	Q-loop/lid; other site
99598008902	ABC transporter signature motif; other site
99598008903	Walker B; other site
99598008904	D-loop; other site
99598008905	H-loop/switch region; other site
99598008906	Putative transcription activator [Transcription]; Region: TenA; COG0819
99598008907	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
99598008908	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
99598008909	active site
99598008910	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
99598008911	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
99598008912	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
99598008913	Predicted transcriptional regulator [Transcription]; Region: COG3682
99598008914	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
99598008915	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
99598008916	amphipathic channel; other site
99598008917	Asn-Pro-Ala signature motifs; other site
99598008918	ribonuclease Z; Region: RNase_Z; TIGR02651
99598008919	phosphoribulokinase; Provisional; Region: PRK07429
99598008920	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
99598008921	active site
99598008922	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
99598008923	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598008924	S-adenosylmethionine binding site [chemical binding]; other site
99598008925	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
99598008926	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
99598008927	Sulfatase; Region: Sulfatase; pfam00884
99598008928	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
99598008929	Domain of unknown function (DUF202); Region: DUF202; pfam02656
99598008930	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
99598008931	Cytochrome P450; Region: p450; cl12078
99598008932	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
99598008933	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
99598008934	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
99598008935	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
99598008936	active site residue [active]
99598008937	Protein of unknown function (DUF938); Region: DUF938; pfam06080
99598008938	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
99598008939	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
99598008940	trimer interface [polypeptide binding]; other site
99598008941	active site
99598008942	substrate binding site [chemical binding]; other site
99598008943	CoA binding site [chemical binding]; other site
99598008944	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
99598008945	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
99598008946	trimer interface [polypeptide binding]; other site
99598008947	active site
99598008948	substrate binding site [chemical binding]; other site
99598008949	CoA binding site [chemical binding]; other site
99598008950	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
99598008951	putative trimer interface [polypeptide binding]; other site
99598008952	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
99598008953	putative CoA binding site [chemical binding]; other site
99598008954	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
99598008955	trimer interface [polypeptide binding]; other site
99598008956	active site
99598008957	substrate binding site [chemical binding]; other site
99598008958	CoA binding site [chemical binding]; other site
99598008959	Phosphate acyltransferases; Region: PlsC; smart00563
99598008960	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
99598008961	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
99598008962	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
99598008963	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
99598008964	substrate binding site [chemical binding]; other site
99598008965	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
99598008966	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
99598008967	substrate binding site [chemical binding]; other site
99598008968	ligand binding site [chemical binding]; other site
99598008969	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
99598008970	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
99598008971	cofactor binding site; other site
99598008972	DNA binding site [nucleotide binding]
99598008973	substrate interaction site [chemical binding]; other site
99598008974	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
99598008975	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
99598008976	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
99598008977	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
99598008978	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
99598008979	ligand binding site [chemical binding]; other site
99598008980	homodimer interface [polypeptide binding]; other site
99598008981	NAD(P) binding site [chemical binding]; other site
99598008982	trimer interface B [polypeptide binding]; other site
99598008983	trimer interface A [polypeptide binding]; other site
99598008984	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
99598008985	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
99598008986	ribonuclease P; Reviewed; Region: rnpA; PRK03031
99598008987	Bacterial PH domain; Region: DUF304; pfam03703
99598008988	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
99598008989	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
99598008990	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
99598008991	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
99598008992	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
99598008993	G-X-X-G motif; other site
99598008994	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
99598008995	RxxxH motif; other site
99598008996	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
99598008997	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
99598008998	Ycf46; Provisional; Region: ycf46; CHL00195
99598008999	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598009000	Walker A motif; other site
99598009001	ATP binding site [chemical binding]; other site
99598009002	Walker B motif; other site
99598009003	arginine finger; other site
99598009004	conjugal transfer protein TraD; Provisional; Region: PRK13700
99598009005	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
99598009006	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598009007	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
99598009008	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598009009	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
99598009010	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598009011	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598009012	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598009013	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598009014	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598009015	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
99598009016	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99598009017	metal binding site [ion binding]; metal-binding site
99598009018	active site
99598009019	I-site; other site
99598009020	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99598009021	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
99598009022	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
99598009023	Walker A/P-loop; other site
99598009024	ATP binding site [chemical binding]; other site
99598009025	Q-loop/lid; other site
99598009026	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598009027	ABC transporter signature motif; other site
99598009028	Walker B; other site
99598009029	D-loop; other site
99598009030	H-loop/switch region; other site
99598009031	S-layer homology domain; Region: SLH; pfam00395
99598009032	S-layer homology domain; Region: SLH; pfam00395
99598009033	S-layer homology domain; Region: SLH; pfam00395
99598009034	GAF domain; Region: GAF; cl17456
99598009035	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598009036	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598009037	dimer interface [polypeptide binding]; other site
99598009038	phosphorylation site [posttranslational modification]
99598009039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598009040	ATP binding site [chemical binding]; other site
99598009041	Mg2+ binding site [ion binding]; other site
99598009042	G-X-G motif; other site
99598009043	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
99598009044	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
99598009045	Predicted transcriptional regulators [Transcription]; Region: COG1695
99598009046	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
99598009047	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
99598009048	seryl-tRNA synthetase; Provisional; Region: PRK05431
99598009049	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
99598009050	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
99598009051	dimer interface [polypeptide binding]; other site
99598009052	active site
99598009053	motif 1; other site
99598009054	motif 2; other site
99598009055	motif 3; other site
99598009056	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598009057	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
99598009058	putative active site [active]
99598009059	RIP metalloprotease RseP; Region: TIGR00054
99598009060	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
99598009061	active site
99598009062	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
99598009063	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
99598009064	putative substrate binding region [chemical binding]; other site
99598009065	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
99598009066	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
99598009067	minor groove reading motif; other site
99598009068	helix-hairpin-helix signature motif; other site
99598009069	substrate binding pocket [chemical binding]; other site
99598009070	active site
99598009071	ribosomal protein S14; Region: rps14; CHL00074
99598009072	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
99598009073	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598009074	putative active site [active]
99598009075	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99598009076	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598009077	Walker A/P-loop; other site
99598009078	ATP binding site [chemical binding]; other site
99598009079	Q-loop/lid; other site
99598009080	ABC transporter signature motif; other site
99598009081	Walker B; other site
99598009082	D-loop; other site
99598009083	H-loop/switch region; other site
99598009084	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598009085	TPR repeat; Region: TPR_11; pfam13414
99598009086	binding surface
99598009087	TPR motif; other site
99598009088	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598009089	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598009090	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598009091	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598009092	active site
99598009093	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
99598009094	extended (e) SDRs; Region: SDR_e; cd08946
99598009095	NAD(P) binding site [chemical binding]; other site
99598009096	active site
99598009097	substrate binding site [chemical binding]; other site
99598009098	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
99598009099	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598009100	active site
99598009101	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
99598009102	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
99598009103	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
99598009104	PQQ-like domain; Region: PQQ_2; pfam13360
99598009105	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
99598009106	Trp docking motif [polypeptide binding]; other site
99598009107	active site
99598009108	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
99598009109	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
99598009110	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
99598009111	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
99598009112	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
99598009113	active site
99598009114	catalytic residues [active]
99598009115	metal binding site [ion binding]; metal-binding site
99598009116	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598009117	binding surface
99598009118	TPR motif; other site
99598009119	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598009120	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598009121	binding surface
99598009122	TPR motif; other site
99598009123	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598009124	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598009125	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598009126	binding surface
99598009127	TPR motif; other site
99598009128	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598009129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598009130	binding surface
99598009131	TPR motif; other site
99598009132	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598009133	CHAT domain; Region: CHAT; pfam12770
99598009134	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
99598009135	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
99598009136	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
99598009137	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
99598009138	DNA photolyase; Region: DNA_photolyase; pfam00875
99598009139	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4446
99598009140	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
99598009141	Cupin domain; Region: Cupin_2; cl17218
99598009142	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
99598009143	Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480
99598009144	Pheophorbide a oxygenase; Region: PaO; pfam08417
99598009145	Cytochrome P450; Region: p450; pfam00067
99598009146	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
99598009147	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
99598009148	Stage II sporulation protein; Region: SpoIID; pfam08486
99598009149	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
99598009150	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
99598009151	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598009152	putative active site [active]
99598009153	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
99598009154	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
99598009155	dimer interface [polypeptide binding]; other site
99598009156	putative functional site; other site
99598009157	putative MPT binding site; other site
99598009158	RDD family; Region: RDD; pfam06271
99598009159	ribosomal protein L33; Region: rpl33; CHL00104
99598009160	ribosomal protein S18; Region: rps18; CHL00077
99598009161	Exoribonuclease R [Transcription]; Region: VacB; COG0557
99598009162	RNB domain; Region: RNB; pfam00773
99598009163	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598009164	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598009165	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598009166	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598009167	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598009168	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598009169	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598009170	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
99598009171	hypothetical protein; Validated; Region: PRK07413
99598009172	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
99598009173	Walker A motif; other site
99598009174	homodimer interface [polypeptide binding]; other site
99598009175	ATP binding site [chemical binding]; other site
99598009176	hydroxycobalamin binding site [chemical binding]; other site
99598009177	Walker B motif; other site
99598009178	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
99598009179	Walker A motif; other site
99598009180	homodimer interface [polypeptide binding]; other site
99598009181	ATP binding site [chemical binding]; other site
99598009182	hydroxycobalamin binding site [chemical binding]; other site
99598009183	Walker B motif; other site
99598009184	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
99598009185	ATP-grasp domain; Region: ATP-grasp_4; cl17255
99598009186	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
99598009187	Chain length determinant protein; Region: Wzz; pfam02706
99598009188	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
99598009189	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99598009190	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
99598009191	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
99598009192	dimerization interface [polypeptide binding]; other site
99598009193	active site
99598009194	metal binding site [ion binding]; metal-binding site
99598009195	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
99598009196	dsRNA binding site [nucleotide binding]; other site
99598009197	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
99598009198	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
99598009199	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
99598009200	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598009201	dimer interface [polypeptide binding]; other site
99598009202	phosphorylation site [posttranslational modification]
99598009203	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598009204	ATP binding site [chemical binding]; other site
99598009205	Mg2+ binding site [ion binding]; other site
99598009206	G-X-G motif; other site
99598009207	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
99598009208	RibD C-terminal domain; Region: RibD_C; cl17279
99598009209	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
99598009210	Protein of unknown function, DUF482; Region: DUF482; pfam04339
99598009211	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
99598009212	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
99598009213	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
99598009214	Repair protein; Region: Repair_PSII; pfam04536
99598009215	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
99598009216	Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370
99598009217	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
99598009218	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
99598009219	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
99598009220	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
99598009221	Bacterial SH3 domain; Region: SH3_3; pfam08239
99598009222	Bacterial SH3 domain; Region: SH3_3; pfam08239
99598009223	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
99598009224	Protein kinase domain; Region: Pkinase; pfam00069
99598009225	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598009226	active site
99598009227	ATP binding site [chemical binding]; other site
99598009228	substrate binding site [chemical binding]; other site
99598009229	activation loop (A-loop); other site
99598009230	AAA ATPase domain; Region: AAA_16; pfam13191
99598009231	Predicted ATPase [General function prediction only]; Region: COG3899
99598009232	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598009233	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598009234	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598009235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598009236	ATP binding site [chemical binding]; other site
99598009237	Mg2+ binding site [ion binding]; other site
99598009238	G-X-G motif; other site
99598009239	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
99598009240	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
99598009241	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
99598009242	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
99598009243	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
99598009244	Fasciclin domain; Region: Fasciclin; pfam02469
99598009245	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
99598009246	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
99598009247	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
99598009248	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
99598009249	TrkA-N domain; Region: TrkA_N; pfam02254
99598009250	TrkA-C domain; Region: TrkA_C; pfam02080
99598009251	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
99598009252	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
99598009253	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
99598009254	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
99598009255	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
99598009256	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
99598009257	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
99598009258	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
99598009259	active site
99598009260	SAM binding site [chemical binding]; other site
99598009261	homodimer interface [polypeptide binding]; other site
99598009262	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
99598009263	Transposase; Region: DEDD_Tnp_IS110; pfam01548
99598009264	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
99598009265	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
99598009266	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
99598009267	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
99598009268	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
99598009269	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
99598009270	active site
99598009271	catalytic triad [active]
99598009272	oxyanion hole [active]
99598009273	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598009274	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598009275	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598009276	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598009277	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598009278	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
99598009279	NMT1-like family; Region: NMT1_2; pfam13379
99598009280	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
99598009281	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598009282	dimer interface [polypeptide binding]; other site
99598009283	conserved gate region; other site
99598009284	putative PBP binding loops; other site
99598009285	ABC-ATPase subunit interface; other site
99598009286	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
99598009287	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
99598009288	Walker A/P-loop; other site
99598009289	ATP binding site [chemical binding]; other site
99598009290	Q-loop/lid; other site
99598009291	ABC transporter signature motif; other site
99598009292	Walker B; other site
99598009293	D-loop; other site
99598009294	H-loop/switch region; other site
99598009295	NMT1-like family; Region: NMT1_2; pfam13379
99598009296	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
99598009297	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
99598009298	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
99598009299	Walker A/P-loop; other site
99598009300	ATP binding site [chemical binding]; other site
99598009301	Q-loop/lid; other site
99598009302	ABC transporter signature motif; other site
99598009303	Walker B; other site
99598009304	D-loop; other site
99598009305	H-loop/switch region; other site
99598009306	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
99598009307	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
99598009308	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
99598009309	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
99598009310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598009311	active site
99598009312	phosphorylation site [posttranslational modification]
99598009313	intermolecular recognition site; other site
99598009314	dimerization interface [polypeptide binding]; other site
99598009315	CheB methylesterase; Region: CheB_methylest; pfam01339
99598009316	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
99598009317	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
99598009318	dimer interface [polypeptide binding]; other site
99598009319	putative CheW interface [polypeptide binding]; other site
99598009320	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
99598009321	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
99598009322	putative binding surface; other site
99598009323	active site
99598009324	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
99598009325	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
99598009326	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598009327	ATP binding site [chemical binding]; other site
99598009328	Mg2+ binding site [ion binding]; other site
99598009329	G-X-G motif; other site
99598009330	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
99598009331	CheW-like domain; Region: CheW; pfam01584
99598009332	Response regulator receiver domain; Region: Response_reg; pfam00072
99598009333	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598009334	active site
99598009335	phosphorylation site [posttranslational modification]
99598009336	intermolecular recognition site; other site
99598009337	dimerization interface [polypeptide binding]; other site
99598009338	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
99598009339	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
99598009340	PAS domain; Region: PAS_9; pfam13426
99598009341	putative active site [active]
99598009342	heme pocket [chemical binding]; other site
99598009343	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598009344	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598009345	dimer interface [polypeptide binding]; other site
99598009346	phosphorylation site [posttranslational modification]
99598009347	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598009348	ATP binding site [chemical binding]; other site
99598009349	Mg2+ binding site [ion binding]; other site
99598009350	G-X-G motif; other site
99598009351	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598009352	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598009353	active site
99598009354	phosphorylation site [posttranslational modification]
99598009355	intermolecular recognition site; other site
99598009356	dimerization interface [polypeptide binding]; other site
99598009357	RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623
99598009358	tRNAHis guanylyltransferase; Region: Thg1; pfam04446
99598009359	Thg1 C terminal domain; Region: Thg1C; pfam14413
99598009360	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
99598009361	active site
99598009362	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
99598009363	phosphoglyceromutase; Provisional; Region: PRK05434
99598009364	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
99598009365	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
99598009366	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598009367	Walker A/P-loop; other site
99598009368	ATP binding site [chemical binding]; other site
99598009369	Q-loop/lid; other site
99598009370	ABC transporter signature motif; other site
99598009371	Walker B; other site
99598009372	D-loop; other site
99598009373	H-loop/switch region; other site
99598009374	ABC transporter; Region: ABC_tran_2; pfam12848
99598009375	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
99598009376	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598009377	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
99598009378	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598009379	sequence-specific DNA binding site [nucleotide binding]; other site
99598009380	salt bridge; other site
99598009381	peptide chain release factor 1; Validated; Region: prfA; PRK00591
99598009382	This domain is found in peptide chain release factors; Region: PCRF; smart00937
99598009383	RF-1 domain; Region: RF-1; pfam00472
99598009384	ribosomal protein L31; Validated; Region: rpl31; CHL00136
99598009385	ribosomal protein S9; Region: rps9; CHL00079
99598009386	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
99598009387	23S rRNA interface [nucleotide binding]; other site
99598009388	L3 interface [polypeptide binding]; other site
99598009389	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
99598009390	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
99598009391	dimerization interface 3.5A [polypeptide binding]; other site
99598009392	active site
99598009393	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
99598009394	RNA polymerase alpha subunit; Region: rpoA; CHL00013
99598009395	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
99598009396	alphaNTD - beta interaction site [polypeptide binding]; other site
99598009397	alphaNTD homodimer interface [polypeptide binding]; other site
99598009398	alphaNTD - beta' interaction site [polypeptide binding]; other site
99598009399	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
99598009400	30S ribosomal protein S11; Validated; Region: PRK05309
99598009401	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
99598009402	30S ribosomal protein S13; Region: bact_S13; TIGR03631
99598009403	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
99598009404	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
99598009405	rRNA binding site [nucleotide binding]; other site
99598009406	predicted 30S ribosome binding site; other site
99598009407	adenylate kinase; Provisional; Region: adk; PRK02496
99598009408	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
99598009409	AMP-binding site [chemical binding]; other site
99598009410	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
99598009411	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
99598009412	SecY translocase; Region: SecY; pfam00344
99598009413	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
99598009414	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
99598009415	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
99598009416	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
99598009417	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
99598009418	5S rRNA interface [nucleotide binding]; other site
99598009419	L27 interface [polypeptide binding]; other site
99598009420	23S rRNA interface [nucleotide binding]; other site
99598009421	L5 interface [polypeptide binding]; other site
99598009422	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
99598009423	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
99598009424	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
99598009425	ribosomal protein S8; Region: rps8; CHL00042
99598009426	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
99598009427	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
99598009428	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
99598009429	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
99598009430	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
99598009431	RNA binding site [nucleotide binding]; other site
99598009432	ribosomal protein L14; Region: rpl14; CHL00057
99598009433	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
99598009434	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
99598009435	23S rRNA interface [nucleotide binding]; other site
99598009436	putative translocon interaction site; other site
99598009437	signal recognition particle (SRP54) interaction site; other site
99598009438	L23 interface [polypeptide binding]; other site
99598009439	trigger factor interaction site; other site
99598009440	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
99598009441	23S rRNA interface [nucleotide binding]; other site
99598009442	5S rRNA interface [nucleotide binding]; other site
99598009443	putative antibiotic binding site [chemical binding]; other site
99598009444	L25 interface [polypeptide binding]; other site
99598009445	L27 interface [polypeptide binding]; other site
99598009446	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
99598009447	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
99598009448	G-X-X-G motif; other site
99598009449	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
99598009450	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
99598009451	putative translocon binding site; other site
99598009452	protein-rRNA interface [nucleotide binding]; other site
99598009453	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
99598009454	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
99598009455	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
99598009456	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
99598009457	ribosomal protein L23; Region: rpl23; CHL00030
99598009458	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
99598009459	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
99598009460	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
99598009461	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
99598009462	active site
99598009463	XisI protein; Region: XisI; pfam08869
99598009464	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
99598009465	putative active site [active]
99598009466	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
99598009467	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
99598009468	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
99598009469	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
99598009470	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
99598009471	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
99598009472	P-loop; other site
99598009473	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
99598009474	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
99598009475	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
99598009476	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
99598009477	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
99598009478	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
99598009479	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
99598009480	putative active site [active]
99598009481	catalytic triad [active]
99598009482	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
99598009483	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
99598009484	metal binding site 2 [ion binding]; metal-binding site
99598009485	putative DNA binding helix; other site
99598009486	metal binding site 1 [ion binding]; metal-binding site
99598009487	dimer interface [polypeptide binding]; other site
99598009488	structural Zn2+ binding site [ion binding]; other site
99598009489	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598009490	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598009491	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598009492	H+ Antiporter protein; Region: 2A0121; TIGR00900
99598009493	putative substrate translocation pore; other site
99598009494	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
99598009495	Recombination protein O N terminal; Region: RecO_N; pfam11967
99598009496	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
99598009497	intersubunit interface [polypeptide binding]; other site
99598009498	active site
99598009499	catalytic residue [active]
99598009500	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
99598009501	G1 box; other site
99598009502	GTP/Mg2+ binding site [chemical binding]; other site
99598009503	G3 box; other site
99598009504	Switch II region; other site
99598009505	G4 box; other site
99598009506	G5 box; other site
99598009507	Domain of unknown function (DUF697); Region: DUF697; pfam05128
99598009508	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
99598009509	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
99598009510	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598009511	non-specific DNA binding site [nucleotide binding]; other site
99598009512	salt bridge; other site
99598009513	sequence-specific DNA binding site [nucleotide binding]; other site
99598009514	L-asparaginase II; Region: Asparaginase_II; cl01842
99598009515	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
99598009516	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
99598009517	putative glycosyl transferase; Provisional; Region: PRK10307
99598009518	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
99598009519	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
99598009520	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
99598009521	Walker A/P-loop; other site
99598009522	ATP binding site [chemical binding]; other site
99598009523	Q-loop/lid; other site
99598009524	ABC transporter signature motif; other site
99598009525	Walker B; other site
99598009526	D-loop; other site
99598009527	H-loop/switch region; other site
99598009528	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598009529	dimer interface [polypeptide binding]; other site
99598009530	conserved gate region; other site
99598009531	putative PBP binding loops; other site
99598009532	ABC-ATPase subunit interface; other site
99598009533	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
99598009534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598009535	dimer interface [polypeptide binding]; other site
99598009536	conserved gate region; other site
99598009537	putative PBP binding loops; other site
99598009538	ABC-ATPase subunit interface; other site
99598009539	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
99598009540	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598009541	substrate binding pocket [chemical binding]; other site
99598009542	membrane-bound complex binding site; other site
99598009543	hinge residues; other site
99598009544	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
99598009545	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
99598009546	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
99598009547	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
99598009548	anti sigma factor interaction site; other site
99598009549	regulatory phosphorylation site [posttranslational modification]; other site
99598009550	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
99598009551	Bacterial sugar transferase; Region: Bac_transf; pfam02397
99598009552	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
99598009553	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
99598009554	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
99598009555	active site
99598009556	substrate binding site [chemical binding]; other site
99598009557	Mg2+ binding site [ion binding]; other site
99598009558	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
99598009559	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
99598009560	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598009561	Coenzyme A binding pocket [chemical binding]; other site
99598009562	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
99598009563	AMIN domain; Region: AMIN; pfam11741
99598009564	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
99598009565	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
99598009566	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
99598009567	Ligand Binding Site [chemical binding]; other site
99598009568	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
99598009569	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
99598009570	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
99598009571	active site
99598009572	catalytic triad [active]
99598009573	oxyanion hole [active]
99598009574	CAAX protease self-immunity; Region: Abi; pfam02517
99598009575	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
99598009576	phosphopeptide binding site; other site
99598009577	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
99598009578	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
99598009579	phosphopeptide binding site; other site
99598009580	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
99598009581	Active_site [active]
99598009582	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
99598009583	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
99598009584	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
99598009585	cofactor binding site; other site
99598009586	DNA binding site [nucleotide binding]
99598009587	substrate interaction site [chemical binding]; other site
99598009588	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
99598009589	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
99598009590	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
99598009591	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
99598009592	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
99598009593	active site
99598009594	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
99598009595	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
99598009596	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
99598009597	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
99598009598	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
99598009599	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
99598009600	Surface antigen; Region: Bac_surface_Ag; pfam01103
99598009601	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
99598009602	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
99598009603	ATP binding site [chemical binding]; other site
99598009604	active site
99598009605	substrate binding site [chemical binding]; other site
99598009606	GAF domain; Region: GAF_2; pfam13185
99598009607	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598009608	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598009609	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598009610	PAS fold; Region: PAS_4; pfam08448
99598009611	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598009612	putative active site [active]
99598009613	heme pocket [chemical binding]; other site
99598009614	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
99598009615	cyclase homology domain; Region: CHD; cd07302
99598009616	nucleotidyl binding site; other site
99598009617	metal binding site [ion binding]; metal-binding site
99598009618	dimer interface [polypeptide binding]; other site
99598009619	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598009620	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
99598009621	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
99598009622	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
99598009623	NAD binding site [chemical binding]; other site
99598009624	substrate binding site [chemical binding]; other site
99598009625	active site
99598009626	Ycf46; Provisional; Region: ycf46; CHL00195
99598009627	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598009628	Walker A motif; other site
99598009629	ATP binding site [chemical binding]; other site
99598009630	Walker B motif; other site
99598009631	arginine finger; other site
99598009632	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
99598009633	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598009634	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598009635	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
99598009636	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
99598009637	Mg2+ binding site [ion binding]; other site
99598009638	G-X-G motif; other site
99598009639	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
99598009640	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
99598009641	interchain domain interface [polypeptide binding]; other site
99598009642	intrachain domain interface; other site
99598009643	Qi binding site; other site
99598009644	Qo binding site; other site
99598009645	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
99598009646	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
99598009647	Qi binding site; other site
99598009648	intrachain domain interface; other site
99598009649	interchain domain interface [polypeptide binding]; other site
99598009650	heme bH binding site [chemical binding]; other site
99598009651	heme bL binding site [chemical binding]; other site
99598009652	Qo binding site; other site
99598009653	carboxyl-terminal processing protease; Provisional; Region: PLN00049
99598009654	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
99598009655	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
99598009656	protein binding site [polypeptide binding]; other site
99598009657	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
99598009658	Catalytic dyad [active]
99598009659	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
99598009660	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
99598009661	Peptidase family M50; Region: Peptidase_M50; pfam02163
99598009662	active site
99598009663	putative substrate binding region [chemical binding]; other site
99598009664	CpeS-like protein; Region: CpeS; pfam09367
99598009665	HEAT repeats; Region: HEAT_2; pfam13646
99598009666	HEAT repeats; Region: HEAT_2; pfam13646
99598009667	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
99598009668	HEAT repeats; Region: HEAT_2; pfam13646
99598009669	tellurite resistance protein terB; Region: terB; cd07176
99598009670	putative metal binding site [ion binding]; other site
99598009671	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
99598009672	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
99598009673	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
99598009674	putative lipid kinase; Reviewed; Region: PRK13057
99598009675	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
99598009676	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
99598009677	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
99598009678	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
99598009679	active site
99598009680	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
99598009681	Uncharacterized conserved protein [Function unknown]; Region: COG1434
99598009682	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
99598009683	putative active site [active]
99598009684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
99598009685	Predicted kinase [General function prediction only]; Region: COG0645
99598009686	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
99598009687	ATP-binding site [chemical binding]; other site
99598009688	Gluconate-6-phosphate binding site [chemical binding]; other site
99598009689	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
99598009690	5S rRNA interface [nucleotide binding]; other site
99598009691	CTC domain interface [polypeptide binding]; other site
99598009692	L16 interface [polypeptide binding]; other site
99598009693	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
99598009694	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
99598009695	GDP-binding site [chemical binding]; other site
99598009696	ACT binding site; other site
99598009697	IMP binding site; other site
99598009698	CHASE3 domain; Region: CHASE3; pfam05227
99598009699	PAS domain S-box; Region: sensory_box; TIGR00229
99598009700	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598009701	putative active site [active]
99598009702	heme pocket [chemical binding]; other site
99598009703	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
99598009704	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598009705	putative active site [active]
99598009706	heme pocket [chemical binding]; other site
99598009707	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598009708	dimer interface [polypeptide binding]; other site
99598009709	phosphorylation site [posttranslational modification]
99598009710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598009711	ATP binding site [chemical binding]; other site
99598009712	Mg2+ binding site [ion binding]; other site
99598009713	G-X-G motif; other site
99598009714	Response regulator receiver domain; Region: Response_reg; pfam00072
99598009715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598009716	active site
99598009717	phosphorylation site [posttranslational modification]
99598009718	intermolecular recognition site; other site
99598009719	dimerization interface [polypeptide binding]; other site
99598009720	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
99598009721	Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443
99598009722	active site
99598009723	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
99598009724	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
99598009725	putative active site [active]
99598009726	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598009727	putative active site [active]
99598009728	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
99598009729	active site residue [active]
99598009730	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
99598009731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598009732	ATP binding site [chemical binding]; other site
99598009733	Mg2+ binding site [ion binding]; other site
99598009734	G-X-G motif; other site
99598009735	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
99598009736	ATP binding site [chemical binding]; other site
99598009737	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
99598009738	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
99598009739	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
99598009740	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
99598009741	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
99598009742	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
99598009743	phytoene desaturase; Region: phytoene_desat; TIGR02731
99598009744	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99598009745	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
99598009746	active site lid residues [active]
99598009747	substrate binding pocket [chemical binding]; other site
99598009748	catalytic residues [active]
99598009749	substrate-Mg2+ binding site; other site
99598009750	aspartate-rich region 1; other site
99598009751	aspartate-rich region 2; other site
99598009752	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
99598009753	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
99598009754	putative ligand binding site [chemical binding]; other site
99598009755	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
99598009756	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
99598009757	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
99598009758	NlpC/P60 family; Region: NLPC_P60; pfam00877
99598009759	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
99598009760	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
99598009761	Putative Catalytic site; other site
99598009762	DXD motif; other site
99598009763	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598009764	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99598009765	putative substrate translocation pore; other site
99598009766	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598009767	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
99598009768	trimer interface [polypeptide binding]; other site
99598009769	dimer interface [polypeptide binding]; other site
99598009770	putative active site [active]
99598009771	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
99598009772	2TM domain; Region: 2TM; pfam13239
99598009773	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
99598009774	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
99598009775	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
99598009776	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
99598009777	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
99598009778	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
99598009779	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
99598009780	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
99598009781	heme binding pocket [chemical binding]; other site
99598009782	heme ligand [chemical binding]; other site
99598009783	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
99598009784	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
99598009785	active site
99598009786	alanine racemase; Reviewed; Region: alr; PRK00053
99598009787	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
99598009788	active site
99598009789	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
99598009790	dimer interface [polypeptide binding]; other site
99598009791	substrate binding site [chemical binding]; other site
99598009792	catalytic residues [active]
99598009793	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
99598009794	Response regulator receiver domain; Region: Response_reg; pfam00072
99598009795	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598009796	active site
99598009797	phosphorylation site [posttranslational modification]
99598009798	intermolecular recognition site; other site
99598009799	dimerization interface [polypeptide binding]; other site
99598009800	Response regulator receiver domain; Region: Response_reg; pfam00072
99598009801	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598009802	active site
99598009803	phosphorylation site [posttranslational modification]
99598009804	intermolecular recognition site; other site
99598009805	dimerization interface [polypeptide binding]; other site
99598009806	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
99598009807	Cache domain; Region: Cache_1; pfam02743
99598009808	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598009809	dimerization interface [polypeptide binding]; other site
99598009810	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598009811	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598009812	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
99598009813	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
99598009814	dimer interface [polypeptide binding]; other site
99598009815	putative CheW interface [polypeptide binding]; other site
99598009816	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
99598009817	putative binding surface; other site
99598009818	active site
99598009819	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
99598009820	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
99598009821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598009822	ATP binding site [chemical binding]; other site
99598009823	Mg2+ binding site [ion binding]; other site
99598009824	G-X-G motif; other site
99598009825	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
99598009826	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598009827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598009828	active site
99598009829	phosphorylation site [posttranslational modification]
99598009830	intermolecular recognition site; other site
99598009831	dimerization interface [polypeptide binding]; other site
99598009832	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598009833	dimerization interface [polypeptide binding]; other site
99598009834	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598009835	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598009836	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
99598009837	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
99598009838	dimer interface [polypeptide binding]; other site
99598009839	putative CheW interface [polypeptide binding]; other site
99598009840	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598009841	dimerization interface [polypeptide binding]; other site
99598009842	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598009843	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598009844	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
99598009845	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
99598009846	dimer interface [polypeptide binding]; other site
99598009847	putative CheW interface [polypeptide binding]; other site
99598009848	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99598009849	RNA binding surface [nucleotide binding]; other site
99598009850	GAF domain; Region: GAF; cl17456
99598009851	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598009852	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598009853	GAF domain; Region: GAF_3; pfam13492
99598009854	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
99598009855	Histidine kinase; Region: HisKA_3; pfam07730
99598009856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598009857	ATP binding site [chemical binding]; other site
99598009858	Mg2+ binding site [ion binding]; other site
99598009859	G-X-G motif; other site
99598009860	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99598009861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598009862	active site
99598009863	phosphorylation site [posttranslational modification]
99598009864	intermolecular recognition site; other site
99598009865	dimerization interface [polypeptide binding]; other site
99598009866	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598009867	DNA binding residues [nucleotide binding]
99598009868	dimerization interface [polypeptide binding]; other site
99598009869	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
99598009870	Thioredoxin; Region: Thioredoxin_4; pfam13462
99598009871	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
99598009872	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
99598009873	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
99598009874	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
99598009875	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
99598009876	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
99598009877	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
99598009878	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
99598009879	FMN binding site [chemical binding]; other site
99598009880	active site
99598009881	substrate binding site [chemical binding]; other site
99598009882	catalytic residue [active]
99598009883	Protein of unknown function, DUF606; Region: DUF606; pfam04657
99598009884	short chain dehydrogenase; Provisional; Region: PRK06172
99598009885	classical (c) SDRs; Region: SDR_c; cd05233
99598009886	NAD(P) binding site [chemical binding]; other site
99598009887	active site
99598009888	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
99598009889	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99598009890	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598009891	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
99598009892	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598009893	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99598009894	putative substrate translocation pore; other site
99598009895	short chain dehydrogenase; Validated; Region: PRK08264
99598009896	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99598009897	NAD(P) binding site [chemical binding]; other site
99598009898	active site
99598009899	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
99598009900	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
99598009901	NAD binding site [chemical binding]; other site
99598009902	homodimer interface [polypeptide binding]; other site
99598009903	active site
99598009904	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
99598009905	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
99598009906	amphipathic channel; other site
99598009907	Asn-Pro-Ala signature motifs; other site
99598009908	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
99598009909	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
99598009910	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
99598009911	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598009912	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598009913	active site
99598009914	ATP binding site [chemical binding]; other site
99598009915	substrate binding site [chemical binding]; other site
99598009916	activation loop (A-loop); other site
99598009917	GUN4-like; Region: GUN4; pfam05419
99598009918	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
99598009919	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
99598009920	putative active site [active]
99598009921	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
99598009922	putative active site [active]
99598009923	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
99598009924	active site
99598009925	SAM binding site [chemical binding]; other site
99598009926	homodimer interface [polypeptide binding]; other site
99598009927	Response regulator receiver domain; Region: Response_reg; pfam00072
99598009928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598009929	active site
99598009930	phosphorylation site [posttranslational modification]
99598009931	intermolecular recognition site; other site
99598009932	dimerization interface [polypeptide binding]; other site
99598009933	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
99598009934	Response regulator receiver domain; Region: Response_reg; pfam00072
99598009935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598009936	active site
99598009937	phosphorylation site [posttranslational modification]
99598009938	intermolecular recognition site; other site
99598009939	dimerization interface [polypeptide binding]; other site
99598009940	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
99598009941	Caspase domain; Region: Peptidase_C14; pfam00656
99598009942	AAA ATPase domain; Region: AAA_16; pfam13191
99598009943	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
99598009944	oligomer interface [polypeptide binding]; other site
99598009945	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598009946	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
99598009947	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598009948	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
99598009949	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99598009950	RNA binding surface [nucleotide binding]; other site
99598009951	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
99598009952	active site
99598009953	Phycobilisome protein; Region: Phycobilisome; cl08227
99598009954	Phycobilisome protein; Region: Phycobilisome; cl08227
99598009955	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
99598009956	CpcD/allophycocyanin linker domain; Region: CpcD; smart01094
99598009957	HEAT repeats; Region: HEAT_2; pfam13646
99598009958	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
99598009959	HEAT repeats; Region: HEAT_2; pfam13646
99598009960	HEAT repeats; Region: HEAT_2; pfam13646
99598009961	Phycobilisome protein; Region: Phycobilisome; cl08227
99598009962	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
99598009963	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
99598009964	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
99598009965	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
99598009966	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
99598009967	HEAT repeats; Region: HEAT_2; pfam13646
99598009968	HEAT repeats; Region: HEAT_2; pfam13646
99598009969	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
99598009970	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
99598009971	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
99598009972	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
99598009973	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
99598009974	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
99598009975	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598009976	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598009977	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99598009978	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598009979	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
99598009980	Walker A/P-loop; other site
99598009981	ATP binding site [chemical binding]; other site
99598009982	Q-loop/lid; other site
99598009983	ABC transporter signature motif; other site
99598009984	Walker B; other site
99598009985	D-loop; other site
99598009986	H-loop/switch region; other site
99598009987	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598009988	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598009989	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
99598009990	Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051
99598009991	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
99598009992	ABC1 family; Region: ABC1; cl17513
99598009993	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
99598009994	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
99598009995	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
99598009996	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
99598009997	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
99598009998	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598009999	Walker A motif; other site
99598010000	ATP binding site [chemical binding]; other site
99598010001	Walker B motif; other site
99598010002	arginine finger; other site
99598010003	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
99598010004	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
99598010005	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
99598010006	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
99598010007	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
99598010008	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
99598010009	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
99598010010	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
99598010011	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
99598010012	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
99598010013	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
99598010014	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
99598010015	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
99598010016	Zn binding site [ion binding]; other site
99598010017	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
99598010018	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
99598010019	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
99598010020	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598010021	S-adenosylmethionine binding site [chemical binding]; other site
99598010022	Protease prsW family; Region: PrsW-protease; cl15823
99598010023	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598010024	putative active site [active]
99598010025	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
99598010026	active site
99598010027	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
99598010028	active site
99598010029	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598010030	putative active site [active]
99598010031	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
99598010032	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99598010033	HSP70 interaction site [polypeptide binding]; other site
99598010034	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
99598010035	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
99598010036	dimer interface [polypeptide binding]; other site
99598010037	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598010038	catalytic residue [active]
99598010039	Predicted transcriptional regulator [Transcription]; Region: COG1959
99598010040	Transcriptional regulator; Region: Rrf2; pfam02082
99598010041	S-layer homology domain; Region: SLH; pfam00395
99598010042	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
99598010043	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
99598010044	aromatic arch; other site
99598010045	DCoH dimer interaction site [polypeptide binding]; other site
99598010046	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
99598010047	DCoH tetramer interaction site [polypeptide binding]; other site
99598010048	substrate binding site [chemical binding]; other site
99598010049	photosystem II protein D2; Region: psbD; CHL00004
99598010050	pheophytin binding site; other site
99598010051	chlorophyll binding site; other site
99598010052	quinone binding site; other site
99598010053	Fe binding site [ion binding]; other site
99598010054	hypothetical protein; Provisional; Region: PRK13683
99598010055	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
99598010056	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
99598010057	Walker A/P-loop; other site
99598010058	ATP binding site [chemical binding]; other site
99598010059	Q-loop/lid; other site
99598010060	ABC transporter signature motif; other site
99598010061	Walker B; other site
99598010062	D-loop; other site
99598010063	H-loop/switch region; other site
99598010064	YacP-like NYN domain; Region: NYN_YacP; cl01491
99598010065	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
99598010066	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
99598010067	TPP-binding site [chemical binding]; other site
99598010068	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
99598010069	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
99598010070	Cytochrome P450; Region: p450; pfam00067
99598010071	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
99598010072	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
99598010073	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
99598010074	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
99598010075	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99598010076	Uncharacterized conserved protein [Function unknown]; Region: COG0398
99598010077	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
99598010078	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
99598010079	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
99598010080	mercuric reductase; Validated; Region: PRK06370
99598010081	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99598010082	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
99598010083	argininosuccinate synthase; Provisional; Region: PRK13820
99598010084	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
99598010085	ANP binding site [chemical binding]; other site
99598010086	Substrate Binding Site II [chemical binding]; other site
99598010087	Substrate Binding Site I [chemical binding]; other site
99598010088	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
99598010089	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
99598010090	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
99598010091	anti sigma factor interaction site; other site
99598010092	regulatory phosphorylation site [posttranslational modification]; other site
99598010093	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
99598010094	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
99598010095	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
99598010096	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
99598010097	chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994
99598010098	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
99598010099	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
99598010100	dimer interface [polypeptide binding]; other site
99598010101	active site
99598010102	glycine-pyridoxal phosphate binding site [chemical binding]; other site
99598010103	folate binding site [chemical binding]; other site
99598010104	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
99598010105	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
99598010106	Mg++ binding site [ion binding]; other site
99598010107	putative catalytic motif [active]
99598010108	substrate binding site [chemical binding]; other site
99598010109	competence damage-inducible protein A; Provisional; Region: PRK00549
99598010110	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
99598010111	putative MPT binding site; other site
99598010112	Competence-damaged protein; Region: CinA; pfam02464
99598010113	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
99598010114	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
99598010115	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
99598010116	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
99598010117	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
99598010118	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
99598010119	putative active site [active]
99598010120	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
99598010121	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
99598010122	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
99598010123	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
99598010124	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
99598010125	NAD binding site [chemical binding]; other site
99598010126	putative substrate binding site 2 [chemical binding]; other site
99598010127	putative substrate binding site 1 [chemical binding]; other site
99598010128	active site
99598010129	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
99598010130	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
99598010131	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
99598010132	Ligand Binding Site [chemical binding]; other site
99598010133	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99598010134	Ligand Binding Site [chemical binding]; other site
99598010135	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
99598010136	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
99598010137	antiporter inner membrane protein; Provisional; Region: PRK11670
99598010138	Domain of unknown function DUF59; Region: DUF59; pfam01883
99598010139	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
99598010140	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
99598010141	hydrophobic ligand binding site; other site
99598010142	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
99598010143	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
99598010144	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
99598010145	anti sigma factor interaction site; other site
99598010146	regulatory phosphorylation site [posttranslational modification]; other site
99598010147	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
99598010148	Thf1-like protein; Reviewed; Region: PRK13266
99598010149	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
99598010150	Predicted membrane protein [Function unknown]; Region: COG1950
99598010151	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
99598010152	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
99598010153	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
99598010154	Uncharacterized conserved protein [Function unknown]; Region: COG3339
99598010155	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598010156	active site
99598010157	GxxExxY protein; Region: GxxExxY; TIGR04256
99598010158	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
99598010159	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
99598010160	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
99598010161	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
99598010162	putative active site [active]
99598010163	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
99598010164	MgtE intracellular N domain; Region: MgtE_N; smart00924
99598010165	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
99598010166	Divalent cation transporter; Region: MgtE; pfam01769
99598010167	Predicted transcriptional regulators [Transcription]; Region: COG1695
99598010168	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
99598010169	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
99598010170	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
99598010171	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
99598010172	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598010173	putative active site [active]
99598010174	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
99598010175	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
99598010176	four helix bundle protein; Region: TIGR02436
99598010177	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
99598010178	Caspase domain; Region: Peptidase_C14; pfam00656
99598010179	GUN4-like; Region: GUN4; pfam05419
99598010180	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
99598010181	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
99598010182	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598010183	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
99598010184	putative metal binding site; other site
99598010185	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598010186	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
99598010187	putative ADP-binding pocket [chemical binding]; other site
99598010188	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
99598010189	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
99598010190	active site
99598010191	dimer interface [polypeptide binding]; other site
99598010192	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
99598010193	Ligand Binding Site [chemical binding]; other site
99598010194	Molecular Tunnel; other site
99598010195	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598010196	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
99598010197	putative ADP-binding pocket [chemical binding]; other site
99598010198	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598010199	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
99598010200	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
99598010201	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598010202	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598010203	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598010204	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
99598010205	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598010206	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598010207	active site
99598010208	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598010209	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598010210	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
99598010211	Methyltransferase domain; Region: Methyltransf_23; pfam13489
99598010212	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598010213	S-adenosylmethionine binding site [chemical binding]; other site
99598010214	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598010215	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598010216	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
99598010217	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598010218	active site
99598010219	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598010220	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
99598010221	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598010222	S-adenosylmethionine binding site [chemical binding]; other site
99598010223	putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325
99598010224	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
99598010225	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
99598010226	inhibitor-cofactor binding pocket; inhibition site
99598010227	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598010228	catalytic residue [active]
99598010229	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
99598010230	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
99598010231	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
99598010232	Walker A/P-loop; other site
99598010233	ATP binding site [chemical binding]; other site
99598010234	Q-loop/lid; other site
99598010235	ABC transporter signature motif; other site
99598010236	Walker B; other site
99598010237	D-loop; other site
99598010238	H-loop/switch region; other site
99598010239	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
99598010240	putative carbohydrate binding site [chemical binding]; other site
99598010241	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
99598010242	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
99598010243	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598010244	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
99598010245	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
99598010246	Chain length determinant protein; Region: Wzz; pfam02706
99598010247	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
99598010248	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
99598010249	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
99598010250	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
99598010251	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
99598010252	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
99598010253	RNA binding site [nucleotide binding]; other site
99598010254	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
99598010255	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99598010256	catalytic loop [active]
99598010257	iron binding site [ion binding]; other site
99598010258	Predicted membrane protein [Function unknown]; Region: COG1950
99598010259	hypothetical protein; Validated; Region: PRK09039
99598010260	cytochrome c6; Provisional; Region: PRK13697
99598010261	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
99598010262	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99598010263	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
99598010264	active site
99598010265	catalytic tetrad [active]
99598010266	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
99598010267	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
99598010268	putative active site [active]
99598010269	XisI protein; Region: XisI; pfam08869
99598010270	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
99598010271	HD domain; Region: HD_3; cl17350
99598010272	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
99598010273	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
99598010274	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
99598010275	Gram-negative bacterial tonB protein; Region: TonB; cl10048
99598010276	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
99598010277	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
99598010278	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
99598010279	ligand binding site [chemical binding]; other site
99598010280	NAD binding site [chemical binding]; other site
99598010281	dimerization interface [polypeptide binding]; other site
99598010282	catalytic site [active]
99598010283	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
99598010284	putative L-serine binding site [chemical binding]; other site
99598010285	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
99598010286	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
99598010287	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
99598010288	active site
99598010289	putative substrate binding pocket [chemical binding]; other site
99598010290	Isochorismatase family; Region: Isochorismatase; pfam00857
99598010291	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
99598010292	catalytic triad [active]
99598010293	conserved cis-peptide bond; other site
99598010294	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
99598010295	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
99598010296	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598010297	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598010298	active site
99598010299	ATP binding site [chemical binding]; other site
99598010300	substrate binding site [chemical binding]; other site
99598010301	activation loop (A-loop); other site
99598010302	gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530
99598010303	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
99598010304	Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636
99598010305	putative active site [active]
99598010306	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
99598010307	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
99598010308	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
99598010309	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
99598010310	NodB motif; other site
99598010311	active site
99598010312	catalytic site [active]
99598010313	metal binding site [ion binding]; metal-binding site
99598010314	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
99598010315	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
99598010316	putative active site [active]
99598010317	putative catalytic site [active]
99598010318	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
99598010319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
99598010320	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
99598010321	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99598010322	catalytic loop [active]
99598010323	iron binding site [ion binding]; other site
99598010324	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
99598010325	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
99598010326	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
99598010327	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
99598010328	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
99598010329	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
99598010330	XdhC Rossmann domain; Region: XdhC_C; pfam13478
99598010331	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
99598010332	Ligand binding site; other site
99598010333	metal-binding site
99598010334	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
99598010335	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
99598010336	Predicted membrane protein [Function unknown]; Region: COG4270
99598010337	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
99598010338	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
99598010339	putative ligand binding site [chemical binding]; other site
99598010340	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
99598010341	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
99598010342	Walker A/P-loop; other site
99598010343	ATP binding site [chemical binding]; other site
99598010344	Q-loop/lid; other site
99598010345	ABC transporter signature motif; other site
99598010346	Walker B; other site
99598010347	D-loop; other site
99598010348	H-loop/switch region; other site
99598010349	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
99598010350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598010351	active site
99598010352	phosphorylation site [posttranslational modification]
99598010353	intermolecular recognition site; other site
99598010354	dimerization interface [polypeptide binding]; other site
99598010355	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
99598010356	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598010357	putative active site [active]
99598010358	heme pocket [chemical binding]; other site
99598010359	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598010360	dimer interface [polypeptide binding]; other site
99598010361	phosphorylation site [posttranslational modification]
99598010362	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598010363	ATP binding site [chemical binding]; other site
99598010364	Mg2+ binding site [ion binding]; other site
99598010365	G-X-G motif; other site
99598010366	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598010367	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598010368	active site
99598010369	phosphorylation site [posttranslational modification]
99598010370	intermolecular recognition site; other site
99598010371	dimerization interface [polypeptide binding]; other site
99598010372	Response regulator receiver domain; Region: Response_reg; pfam00072
99598010373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598010374	active site
99598010375	phosphorylation site [posttranslational modification]
99598010376	intermolecular recognition site; other site
99598010377	dimerization interface [polypeptide binding]; other site
99598010378	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598010379	PAS fold; Region: PAS_3; pfam08447
99598010380	putative active site [active]
99598010381	heme pocket [chemical binding]; other site
99598010382	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598010383	GAF domain; Region: GAF; pfam01590
99598010384	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598010385	PAS fold; Region: PAS_3; pfam08447
99598010386	putative active site [active]
99598010387	heme pocket [chemical binding]; other site
99598010388	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598010389	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598010390	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598010391	dimer interface [polypeptide binding]; other site
99598010392	phosphorylation site [posttranslational modification]
99598010393	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598010394	ATP binding site [chemical binding]; other site
99598010395	Mg2+ binding site [ion binding]; other site
99598010396	G-X-G motif; other site
99598010397	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
99598010398	MoaE homodimer interface [polypeptide binding]; other site
99598010399	MoaD interaction [polypeptide binding]; other site
99598010400	active site residues [active]
99598010401	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
99598010402	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99598010403	Permease; Region: Permease; cl00510
99598010404	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
99598010405	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
99598010406	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
99598010407	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
99598010408	G1 box; other site
99598010409	GTP/Mg2+ binding site [chemical binding]; other site
99598010410	G2 box; other site
99598010411	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
99598010412	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598010413	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598010414	ligand binding site [chemical binding]; other site
99598010415	flexible hinge region; other site
99598010416	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
99598010417	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
99598010418	putative catalytic cysteine [active]
99598010419	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
99598010420	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598010421	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598010422	ligand binding site [chemical binding]; other site
99598010423	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
99598010424	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598010425	DevC protein; Region: devC; TIGR01185
99598010426	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
99598010427	FtsX-like permease family; Region: FtsX; pfam02687
99598010428	DevC protein; Region: devC; TIGR01185
99598010429	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
99598010430	FtsX-like permease family; Region: FtsX; pfam02687
99598010431	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
99598010432	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
99598010433	Walker A/P-loop; other site
99598010434	ATP binding site [chemical binding]; other site
99598010435	Q-loop/lid; other site
99598010436	ABC transporter signature motif; other site
99598010437	Walker B; other site
99598010438	D-loop; other site
99598010439	H-loop/switch region; other site
99598010440	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598010441	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598010442	acyl-CoA synthetase; Validated; Region: PRK05850
99598010443	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
99598010444	acyl-activating enzyme (AAE) consensus motif; other site
99598010445	active site
99598010446	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
99598010447	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
99598010448	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
99598010449	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598010450	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598010451	TPR repeat; Region: TPR_11; pfam13414
99598010452	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598010453	binding surface
99598010454	TPR motif; other site
99598010455	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598010456	binding surface
99598010457	TPR motif; other site
99598010458	TPR repeat; Region: TPR_11; pfam13414
99598010459	NAD synthetase; Provisional; Region: PRK13981
99598010460	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
99598010461	multimer interface [polypeptide binding]; other site
99598010462	active site
99598010463	catalytic triad [active]
99598010464	protein interface 1 [polypeptide binding]; other site
99598010465	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
99598010466	homodimer interface [polypeptide binding]; other site
99598010467	NAD binding pocket [chemical binding]; other site
99598010468	ATP binding pocket [chemical binding]; other site
99598010469	Mg binding site [ion binding]; other site
99598010470	active-site loop [active]
99598010471	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
99598010472	nudix motif; other site
99598010473	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
99598010474	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
99598010475	active site
99598010476	(T/H)XGH motif; other site
99598010477	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
99598010478	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
99598010479	active site
99598010480	Transcriptional regulator [Transcription]; Region: LytR; COG1316
99598010481	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
99598010482	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
99598010483	Domain of unknown function DUF20; Region: UPF0118; pfam01594
99598010484	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
99598010485	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
99598010486	Peptidase family M50; Region: Peptidase_M50; pfam02163
99598010487	active site
99598010488	putative substrate binding region [chemical binding]; other site
99598010489	FOG: CBS domain [General function prediction only]; Region: COG0517
99598010490	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
99598010491	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598010492	non-specific DNA binding site [nucleotide binding]; other site
99598010493	salt bridge; other site
99598010494	sequence-specific DNA binding site [nucleotide binding]; other site
99598010495	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
99598010496	XisH protein; Region: XisH; pfam08814
99598010497	XisI protein; Region: XisI; pfam08869
99598010498	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
99598010499	metal ion-dependent adhesion site (MIDAS); other site
99598010500	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
99598010501	metal ion-dependent adhesion site (MIDAS); other site
99598010502	Predicted transcriptional regulators [Transcription]; Region: COG1733
99598010503	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
99598010504	dimerization interface [polypeptide binding]; other site
99598010505	putative DNA binding site [nucleotide binding]; other site
99598010506	putative Zn2+ binding site [ion binding]; other site
99598010507	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
99598010508	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
99598010509	2TM domain; Region: 2TM; pfam13239
99598010510	Creatinine amidohydrolase; Region: Creatininase; pfam02633
99598010511	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
99598010512	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
99598010513	putative active site [active]
99598010514	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
99598010515	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
99598010516	nucleotide binding site [chemical binding]; other site
99598010517	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
99598010518	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598010519	Walker A/P-loop; other site
99598010520	ATP binding site [chemical binding]; other site
99598010521	Q-loop/lid; other site
99598010522	ABC transporter signature motif; other site
99598010523	Walker B; other site
99598010524	D-loop; other site
99598010525	H-loop/switch region; other site
99598010526	ABC-2 type transporter; Region: ABC2_membrane; cl17235
99598010527	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
99598010528	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
99598010529	Transposase; Region: DEDD_Tnp_IS110; pfam01548
99598010530	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
99598010531	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
99598010532	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
99598010533	catalytic triad [active]
99598010534	cobyric acid synthase; Provisional; Region: PRK00784
99598010535	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99598010536	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99598010537	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
99598010538	catalytic triad [active]
99598010539	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99598010540	catalytic loop [active]
99598010541	iron binding site [ion binding]; other site
99598010542	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598010543	putative active site [active]
99598010544	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
99598010545	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
99598010546	excinuclease ABC subunit B; Provisional; Region: PRK05298
99598010547	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598010548	ATP binding site [chemical binding]; other site
99598010549	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598010550	nucleotide binding region [chemical binding]; other site
99598010551	ATP-binding site [chemical binding]; other site
99598010552	Ultra-violet resistance protein B; Region: UvrB; pfam12344
99598010553	CsbD-like; Region: CsbD; pfam05532
99598010554	cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153
99598010555	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
99598010556	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
99598010557	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
99598010558	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
99598010559	substrate binding site [chemical binding]; other site
99598010560	hexamer interface [polypeptide binding]; other site
99598010561	metal binding site [ion binding]; metal-binding site
99598010562	Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488
99598010563	putative catalytic residues [active]
99598010564	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
99598010565	putative active site [active]
99598010566	serpin-like protein; Provisional; Region: PHA02660
99598010567	SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049
99598010568	reactive center loop; other site
99598010569	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
99598010570	dimerization interface [polypeptide binding]; other site
99598010571	putative DNA binding site [nucleotide binding]; other site
99598010572	putative Zn2+ binding site [ion binding]; other site
99598010573	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
99598010574	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
99598010575	catalytic residues [active]
99598010576	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
99598010577	classical (c) SDRs; Region: SDR_c; cd05233
99598010578	NAD(P) binding site [chemical binding]; other site
99598010579	active site
99598010580	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
99598010581	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
99598010582	FMN binding site [chemical binding]; other site
99598010583	active site
99598010584	substrate binding site [chemical binding]; other site
99598010585	catalytic residue [active]
99598010586	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
99598010587	dimer interface [polypeptide binding]; other site
99598010588	FMN binding site [chemical binding]; other site
99598010589	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598010590	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99598010591	putative substrate translocation pore; other site
99598010592	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99598010593	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
99598010594	NAD(P) binding site [chemical binding]; other site
99598010595	active site
99598010596	Methyltransferase domain; Region: Methyltransf_31; pfam13847
99598010597	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598010598	S-adenosylmethionine binding site [chemical binding]; other site
99598010599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598010600	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
99598010601	putative substrate translocation pore; other site
99598010602	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
99598010603	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
99598010604	C-terminal domain interface [polypeptide binding]; other site
99598010605	GSH binding site (G-site) [chemical binding]; other site
99598010606	dimer interface [polypeptide binding]; other site
99598010607	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
99598010608	N-terminal domain interface [polypeptide binding]; other site
99598010609	putative dimer interface [polypeptide binding]; other site
99598010610	active site
99598010611	Protein of unknown function (DUF1399); Region: DUF1399; pfam07173
99598010612	Peptidase family M48; Region: Peptidase_M48; cl12018
99598010613	Peptidase family M48; Region: Peptidase_M48; cl12018
99598010614	NB-ARC domain; Region: NB-ARC; pfam00931
99598010615	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598010616	TPR motif; other site
99598010617	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598010618	binding surface
99598010619	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598010620	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
99598010621	binding surface
99598010622	TPR motif; other site
99598010623	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598010624	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598010625	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598010626	active site
99598010627	ATP binding site [chemical binding]; other site
99598010628	substrate binding site [chemical binding]; other site
99598010629	activation loop (A-loop); other site
99598010630	TPR repeat; Region: TPR_11; pfam13414
99598010631	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
99598010632	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
99598010633	putative ligand binding site [chemical binding]; other site
99598010634	AAA ATPase domain; Region: AAA_16; pfam13191
99598010635	NACHT domain; Region: NACHT; pfam05729
99598010636	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
99598010637	putative active site [active]
99598010638	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
99598010639	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99598010640	dephospho-CoA kinase; Region: TIGR00152
99598010641	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
99598010642	CoA-binding site [chemical binding]; other site
99598010643	ATP-binding [chemical binding]; other site
99598010644	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
99598010645	active site
99598010646	SAM binding site [chemical binding]; other site
99598010647	homodimer interface [polypeptide binding]; other site
99598010648	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
99598010649	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
99598010650	active site
99598010651	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
99598010652	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
99598010653	active site
99598010654	catalytic residues [active]
99598010655	metal binding site [ion binding]; metal-binding site
99598010656	Predicted membrane protein [Function unknown]; Region: COG3431
99598010657	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
99598010658	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598010659	active site
99598010660	motif I; other site
99598010661	motif II; other site
99598010662	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
99598010663	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
99598010664	active site
99598010665	trimer interface [polypeptide binding]; other site
99598010666	allosteric site; other site
99598010667	active site lid [active]
99598010668	hexamer (dimer of trimers) interface [polypeptide binding]; other site
99598010669	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
99598010670	PAS fold; Region: PAS_4; pfam08448
99598010671	PAS domain S-box; Region: sensory_box; TIGR00229
99598010672	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598010673	putative active site [active]
99598010674	heme pocket [chemical binding]; other site
99598010675	PAS domain S-box; Region: sensory_box; TIGR00229
99598010676	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598010677	putative active site [active]
99598010678	heme pocket [chemical binding]; other site
99598010679	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598010680	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598010681	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598010682	GAF domain; Region: GAF; pfam01590
99598010683	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598010684	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598010685	dimer interface [polypeptide binding]; other site
99598010686	phosphorylation site [posttranslational modification]
99598010687	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598010688	ATP binding site [chemical binding]; other site
99598010689	Mg2+ binding site [ion binding]; other site
99598010690	G-X-G motif; other site
99598010691	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598010692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598010693	active site
99598010694	phosphorylation site [posttranslational modification]
99598010695	intermolecular recognition site; other site
99598010696	dimerization interface [polypeptide binding]; other site
99598010697	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
99598010698	TrkA-N domain; Region: TrkA_N; pfam02254
99598010699	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
99598010700	TrkA-N domain; Region: TrkA_N; pfam02254
99598010701	GxxExxY protein; Region: GxxExxY; TIGR04256
99598010702	BON domain; Region: BON; pfam04972
99598010703	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598010704	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
99598010705	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598010706	putative active site [active]
99598010707	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
99598010708	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
99598010709	Transposase IS200 like; Region: Y1_Tnp; cl00848
99598010710	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598010711	oligomeric interface; other site
99598010712	putative active site [active]
99598010713	homodimer interface [polypeptide binding]; other site
99598010714	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
99598010715	Protein of unknown function (DUF499); Region: DUF499; pfam04465
99598010716	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069
99598010717	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598010718	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598010719	dimer interface [polypeptide binding]; other site
99598010720	phosphorylation site [posttranslational modification]
99598010721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598010722	ATP binding site [chemical binding]; other site
99598010723	Mg2+ binding site [ion binding]; other site
99598010724	G-X-G motif; other site
99598010725	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
99598010726	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
99598010727	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
99598010728	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
99598010729	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
99598010730	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598010731	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598010732	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598010733	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598010734	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
99598010735	NADH(P)-binding; Region: NAD_binding_10; pfam13460
99598010736	NAD(P) binding site [chemical binding]; other site
99598010737	putative active site [active]
99598010738	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
99598010739	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
99598010740	putative dimer interface [polypeptide binding]; other site
99598010741	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
99598010742	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
99598010743	cyclase homology domain; Region: CHD; cd07302
99598010744	nucleotidyl binding site; other site
99598010745	metal binding site [ion binding]; metal-binding site
99598010746	dimer interface [polypeptide binding]; other site
99598010747	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
99598010748	Protein of unknown function (DUF433); Region: DUF433; cl01030
99598010749	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598010750	structural tetrad; other site
99598010751	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598010752	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598010753	structural tetrad; other site
99598010754	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598010755	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
99598010756	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
99598010757	putative active site [active]
99598010758	putative hydrolase; Provisional; Region: PRK11460
99598010759	Predicted esterase [General function prediction only]; Region: COG0400
99598010760	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
99598010761	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
99598010762	Flavoprotein; Region: Flavoprotein; pfam02441
99598010763	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
99598010764	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
99598010765	Peptidase family M50; Region: Peptidase_M50; pfam02163
99598010766	active site
99598010767	putative substrate binding region [chemical binding]; other site
99598010768	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
99598010769	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
99598010770	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
99598010771	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
99598010772	active site
99598010773	substrate binding site [chemical binding]; other site
99598010774	FMN binding site [chemical binding]; other site
99598010775	putative catalytic residues [active]
99598010776	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
99598010777	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
99598010778	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
99598010779	hinge; other site
99598010780	active site
99598010781	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
99598010782	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
99598010783	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
99598010784	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
99598010785	active site
99598010786	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
99598010787	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
99598010788	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
99598010789	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
99598010790	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
99598010791	generic binding surface I; other site
99598010792	generic binding surface II; other site
99598010793	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
99598010794	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
99598010795	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
99598010796	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99598010797	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
99598010798	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598010799	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598010800	Walker A/P-loop; other site
99598010801	ATP binding site [chemical binding]; other site
99598010802	Q-loop/lid; other site
99598010803	ABC transporter signature motif; other site
99598010804	Walker B; other site
99598010805	D-loop; other site
99598010806	H-loop/switch region; other site
99598010807	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
99598010808	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
99598010809	putative active site [active]
99598010810	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598010811	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598010812	Walker A/P-loop; other site
99598010813	ATP binding site [chemical binding]; other site
99598010814	Q-loop/lid; other site
99598010815	ABC transporter signature motif; other site
99598010816	Walker B; other site
99598010817	D-loop; other site
99598010818	H-loop/switch region; other site
99598010819	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
99598010820	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99598010821	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598010822	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598010823	bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896
99598010824	ligand binding site [chemical binding]; other site
99598010825	flexible hinge region; other site
99598010826	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598010827	ligand binding site [chemical binding]; other site
99598010828	flexible hinge region; other site
99598010829	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99598010830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598010831	active site
99598010832	phosphorylation site [posttranslational modification]
99598010833	intermolecular recognition site; other site
99598010834	dimerization interface [polypeptide binding]; other site
99598010835	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598010836	DNA binding residues [nucleotide binding]
99598010837	dimerization interface [polypeptide binding]; other site
99598010838	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
99598010839	Histidine kinase; Region: HisKA_3; pfam07730
99598010840	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598010841	ATP binding site [chemical binding]; other site
99598010842	Mg2+ binding site [ion binding]; other site
99598010843	G-X-G motif; other site
99598010844	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598010845	non-specific DNA binding site [nucleotide binding]; other site
99598010846	salt bridge; other site
99598010847	sequence-specific DNA binding site [nucleotide binding]; other site
99598010848	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
99598010849	sequence-specific DNA binding site [nucleotide binding]; other site
99598010850	salt bridge; other site
99598010851	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598010852	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598010853	active site
99598010854	ATP binding site [chemical binding]; other site
99598010855	substrate binding site [chemical binding]; other site
99598010856	activation loop (A-loop); other site
99598010857	XisI protein; Region: XisI; pfam08869
99598010858	XisH protein; Region: XisH; pfam08814
99598010859	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
99598010860	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
99598010861	substrate binding site [chemical binding]; other site
99598010862	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
99598010863	substrate binding site [chemical binding]; other site
99598010864	ligand binding site [chemical binding]; other site
99598010865	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
99598010866	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99598010867	catalytic loop [active]
99598010868	iron binding site [ion binding]; other site
99598010869	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
99598010870	CAAX protease self-immunity; Region: Abi; pfam02517
99598010871	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
99598010872	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
99598010873	active site
99598010874	substrate binding site [chemical binding]; other site
99598010875	cosubstrate binding site; other site
99598010876	catalytic site [active]
99598010877	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
99598010878	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
99598010879	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
99598010880	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
99598010881	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598010882	FeS/SAM binding site; other site
99598010883	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
99598010884	Yip1 domain; Region: Yip1; pfam04893
99598010885	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
99598010886	Double zinc ribbon; Region: DZR; pfam12773
99598010887	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
99598010888	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
99598010889	putative NAD(P) binding site [chemical binding]; other site
99598010890	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
99598010891	2-isopropylmalate synthase; Validated; Region: PRK03739
99598010892	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
99598010893	active site
99598010894	catalytic residues [active]
99598010895	metal binding site [ion binding]; metal-binding site
99598010896	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
99598010897	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
99598010898	putative active site pocket [active]
99598010899	dimerization interface [polypeptide binding]; other site
99598010900	putative catalytic residue [active]
99598010901	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
99598010902	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
99598010903	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
99598010904	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598010905	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598010906	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598010907	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598010908	O-Antigen ligase; Region: Wzy_C; cl04850
99598010909	light-harvesting-like protein 3; Provisional; Region: PLN00014
99598010910	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
99598010911	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99598010912	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
99598010913	Domain of unknown function DUF20; Region: UPF0118; pfam01594
99598010914	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
99598010915	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
99598010916	active site
99598010917	Na/Ca binding site [ion binding]; other site
99598010918	catalytic site [active]
99598010919	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
99598010920	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
99598010921	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
99598010922	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
99598010923	putative substrate binding pocket [chemical binding]; other site
99598010924	catalytic triad [active]
99598010925	AB domain interface; other site
99598010926	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
99598010927	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
99598010928	putative active site [active]
99598010929	oxyanion strand; other site
99598010930	catalytic triad [active]
99598010931	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
99598010932	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598010933	S-adenosylmethionine binding site [chemical binding]; other site
99598010934	cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665
99598010935	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
99598010936	Cytochrome c; Region: Cytochrom_C; pfam00034
99598010937	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
99598010938	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
99598010939	active site
99598010940	Zn binding site [ion binding]; other site
99598010941	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
99598010942	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598010943	binding surface
99598010944	TPR motif; other site
99598010945	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598010946	binding surface
99598010947	TPR motif; other site
99598010948	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
99598010949	haemagglutination activity domain; Region: Haemagg_act; pfam05860
99598010950	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
99598010951	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
99598010952	Radical SAM superfamily; Region: Radical_SAM; pfam04055
99598010953	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598010954	FeS/SAM binding site; other site
99598010955	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
99598010956	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
99598010957	RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911
99598010958	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
99598010959	putative active site [active]
99598010960	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
99598010961	haemagglutination activity domain; Region: Haemagg_act; pfam05860
99598010962	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
99598010963	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
99598010964	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
99598010965	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598010966	ligand binding site [chemical binding]; other site
99598010967	flexible hinge region; other site
99598010968	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
99598010969	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
99598010970	putative active site [active]
99598010971	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598010972	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598010973	Walker A/P-loop; other site
99598010974	ATP binding site [chemical binding]; other site
99598010975	Q-loop/lid; other site
99598010976	ABC transporter signature motif; other site
99598010977	Walker B; other site
99598010978	D-loop; other site
99598010979	H-loop/switch region; other site
99598010980	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
99598010981	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
99598010982	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598010983	haemagglutination activity domain; Region: Haemagg_act; pfam05860
99598010984	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
99598010985	CHAT domain; Region: CHAT; cl17868
99598010986	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
99598010987	CHASE2 domain; Region: CHASE2; pfam05226
99598010988	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
99598010989	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598010990	Radical SAM superfamily; Region: Radical_SAM; pfam04055
99598010991	FeS/SAM binding site; other site
99598010992	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
99598010993	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598010994	FeS/SAM binding site; other site
99598010995	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
99598010996	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
99598010997	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
99598010998	putative NADP binding site [chemical binding]; other site
99598010999	putative substrate binding site [chemical binding]; other site
99598011000	active site
99598011001	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
99598011002	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
99598011003	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
99598011004	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
99598011005	Protein of unknown function DUF58; Region: DUF58; pfam01882
99598011006	MoxR-like ATPases [General function prediction only]; Region: COG0714
99598011007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598011008	Walker A motif; other site
99598011009	ATP binding site [chemical binding]; other site
99598011010	Walker B motif; other site
99598011011	arginine finger; other site
99598011012	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
99598011013	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
99598011014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236
99598011015	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598011016	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598011017	Phytochrome region; Region: PHY; pfam00360
99598011018	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598011019	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598011020	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598011021	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598011022	dimer interface [polypeptide binding]; other site
99598011023	phosphorylation site [posttranslational modification]
99598011024	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598011025	ATP binding site [chemical binding]; other site
99598011026	Mg2+ binding site [ion binding]; other site
99598011027	G-X-G motif; other site
99598011028	LabA_like proteins; Region: LabA_like; cd06167
99598011029	putative metal binding site [ion binding]; other site
99598011030	Uncharacterized conserved protein [Function unknown]; Region: COG1432
99598011031	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
99598011032	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
99598011033	dimerization interface [polypeptide binding]; other site
99598011034	active site
99598011035	metal binding site [ion binding]; metal-binding site
99598011036	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
99598011037	dsRNA binding site [nucleotide binding]; other site
99598011038	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
99598011039	Transposase; Region: DEDD_Tnp_IS110; pfam01548
99598011040	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
99598011041	urea carboxylase; Region: urea_carbox; TIGR02712
99598011042	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
99598011043	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
99598011044	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
99598011045	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
99598011046	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
99598011047	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
99598011048	carboxyltransferase (CT) interaction site; other site
99598011049	biotinylation site [posttranslational modification]; other site
99598011050	tocopherol O-methyltransferase; Region: PLN02244
99598011051	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598011052	S-adenosylmethionine binding site [chemical binding]; other site
99598011053	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
99598011054	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
99598011055	Predicted metal-binding protein [Function unknown]; Region: COG5469
99598011056	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
99598011057	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99598011058	N-terminal plug; other site
99598011059	ligand-binding site [chemical binding]; other site
99598011060	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
99598011061	dimer interface [polypeptide binding]; other site
99598011062	[2Fe-2S] cluster binding site [ion binding]; other site
99598011063	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
99598011064	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
99598011065	putative ligand binding site [chemical binding]; other site
99598011066	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
99598011067	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
99598011068	ABC-ATPase subunit  interface; other site
99598011069	dimer interface [polypeptide binding]; other site
99598011070	putative PBP binding regions; other site
99598011071	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
99598011072	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
99598011073	Walker A/P-loop; other site
99598011074	ATP binding site [chemical binding]; other site
99598011075	Q-loop/lid; other site
99598011076	ABC transporter signature motif; other site
99598011077	Walker B; other site
99598011078	D-loop; other site
99598011079	H-loop/switch region; other site
99598011080	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
99598011081	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
99598011082	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
99598011083	ligand binding site; other site
99598011084	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598011085	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
99598011086	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
99598011087	Walker A/P-loop; other site
99598011088	ATP binding site [chemical binding]; other site
99598011089	Q-loop/lid; other site
99598011090	ABC transporter signature motif; other site
99598011091	Walker B; other site
99598011092	D-loop; other site
99598011093	H-loop/switch region; other site
99598011094	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
99598011095	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
99598011096	DNA methylase; Region: N6_N4_Mtase; pfam01555
99598011097	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
99598011098	putative active site [active]
99598011099	YdjC motif; other site
99598011100	Mg binding site [ion binding]; other site
99598011101	putative homodimer interface [polypeptide binding]; other site
99598011102	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
99598011103	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
99598011104	B12 binding site [chemical binding]; other site
99598011105	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598011106	FeS/SAM binding site; other site
99598011107	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
99598011108	substrate binding pocket [chemical binding]; other site
99598011109	substrate-Mg2+ binding site; other site
99598011110	aspartate-rich region 1; other site
99598011111	aspartate-rich region 2; other site
99598011112	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598011113	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598011114	putative active site [active]
99598011115	heme pocket [chemical binding]; other site
99598011116	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598011117	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598011118	GAF domain; Region: GAF; pfam01590
99598011119	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598011120	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598011121	dimer interface [polypeptide binding]; other site
99598011122	phosphorylation site [posttranslational modification]
99598011123	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598011124	ATP binding site [chemical binding]; other site
99598011125	Mg2+ binding site [ion binding]; other site
99598011126	G-X-G motif; other site
99598011127	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598011128	Response regulator receiver domain; Region: Response_reg; pfam00072
99598011129	active site
99598011130	phosphorylation site [posttranslational modification]
99598011131	intermolecular recognition site; other site
99598011132	dimerization interface [polypeptide binding]; other site
99598011133	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99598011134	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598011135	DNA binding residues [nucleotide binding]
99598011136	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
99598011137	DNA polymerase III subunit delta; Validated; Region: PRK07452
99598011138	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
99598011139	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
99598011140	Predicted membrane protein/domain [Function unknown]; Region: COG1714
99598011141	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
99598011142	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
99598011143	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
99598011144	dinuclear metal binding motif [ion binding]; other site
99598011145	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598011146	putative active site [active]
99598011147	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
99598011148	Glucose inhibited division protein A; Region: GIDA; pfam01134
99598011149	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598011150	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
99598011151	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
99598011152	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
99598011153	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
99598011154	active site
99598011155	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
99598011156	active site 1 [active]
99598011157	dimer interface [polypeptide binding]; other site
99598011158	hexamer interface [polypeptide binding]; other site
99598011159	active site 2 [active]
99598011160	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99598011161	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99598011162	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
99598011163	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
99598011164	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
99598011165	dimer interface [polypeptide binding]; other site
99598011166	active site
99598011167	metal binding site [ion binding]; metal-binding site
99598011168	Nitrogen regulatory protein P-II; Region: P-II; cl00412
99598011169	Domain of unknown function (DUF897); Region: DUF897; pfam05982
99598011170	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598011171	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
99598011172	dimer interface [polypeptide binding]; other site
99598011173	phosphorylation site [posttranslational modification]
99598011174	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598011175	ATP binding site [chemical binding]; other site
99598011176	Mg2+ binding site [ion binding]; other site
99598011177	G-X-G motif; other site
99598011178	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99598011179	HSP70 interaction site [polypeptide binding]; other site
99598011180	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598011181	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598011182	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598011183	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598011184	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13398
99598011185	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
99598011186	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
99598011187	MutS domain I; Region: MutS_I; pfam01624
99598011188	MutS domain II; Region: MutS_II; pfam05188
99598011189	MutS domain III; Region: MutS_III; pfam05192
99598011190	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
99598011191	Walker A/P-loop; other site
99598011192	ATP binding site [chemical binding]; other site
99598011193	Q-loop/lid; other site
99598011194	ABC transporter signature motif; other site
99598011195	Walker B; other site
99598011196	D-loop; other site
99598011197	H-loop/switch region; other site
99598011198	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
99598011199	Domain of unknown function DUF20; Region: UPF0118; pfam01594
99598011200	bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500
99598011201	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
99598011202	active site
99598011203	dimer interface [polypeptide binding]; other site
99598011204	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99598011205	active site
99598011206	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
99598011207	heterotetramer interface [polypeptide binding]; other site
99598011208	active site pocket [active]
99598011209	cleavage site
99598011210	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598011211	putative active site [active]
99598011212	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
99598011213	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
99598011214	putative ligand binding site [chemical binding]; other site
99598011215	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598011216	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598011217	dimerization interface [polypeptide binding]; other site
99598011218	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
99598011219	phosphorylation site [posttranslational modification]
99598011220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598011221	ATP binding site [chemical binding]; other site
99598011222	Mg2+ binding site [ion binding]; other site
99598011223	G-X-G motif; other site
99598011224	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
99598011225	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
99598011226	ATP adenylyltransferase; Region: ATP_transf; pfam09830
99598011227	Uncharacterized conserved protein [Function unknown]; Region: COG2442
99598011228	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
99598011229	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
99598011230	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99598011231	catalytic residue [active]
99598011232	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
99598011233	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
99598011234	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
99598011235	FMN binding site [chemical binding]; other site
99598011236	active site
99598011237	catalytic residues [active]
99598011238	substrate binding site [chemical binding]; other site
99598011239	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
99598011240	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
99598011241	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
99598011242	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
99598011243	vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461
99598011244	metal ion-dependent adhesion site (MIDAS); other site
99598011245	choline dehydrogenase; Validated; Region: PRK02106
99598011246	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
99598011247	Restriction endonuclease BamHI; Region: BamHI; pfam02923
99598011248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598011249	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
99598011250	DNA methylase; Region: N6_N4_Mtase; pfam01555
99598011251	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
99598011252	Helix-turn-helix domain; Region: HTH_17; pfam12728
99598011253	NB-ARC domain; Region: NB-ARC; pfam00931
99598011254	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
99598011255	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
99598011256	NAD(P) binding site [chemical binding]; other site
99598011257	catalytic residues [active]
99598011258	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582
99598011259	Predicted amidohydrolase [General function prediction only]; Region: COG0388
99598011260	putative active site [active]
99598011261	catalytic triad [active]
99598011262	putative dimer interface [polypeptide binding]; other site
99598011263	Red chlorophyll catabolite reductase (RCC reductase); Region: RCC_reductase; cl05747
99598011264	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
99598011265	NADP binding site [chemical binding]; other site
99598011266	active site
99598011267	regulatory binding site [polypeptide binding]; other site
99598011268	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
99598011269	active site
99598011270	putative DNA-binding cleft [nucleotide binding]; other site
99598011271	dimer interface [polypeptide binding]; other site
99598011272	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
99598011273	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
99598011274	phosphate binding site [ion binding]; other site
99598011275	putative substrate binding pocket [chemical binding]; other site
99598011276	dimer interface [polypeptide binding]; other site
99598011277	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
99598011278	dihydroorotase; Provisional; Region: PRK07575
99598011279	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
99598011280	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
99598011281	active site
99598011282	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
99598011283	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
99598011284	Catalytic site [active]
99598011285	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
99598011286	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
99598011287	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
99598011288	Catalytic site [active]
99598011289	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
99598011290	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
99598011291	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
99598011292	MOSC domain; Region: MOSC; pfam03473
99598011293	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598011294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598011295	dimer interface [polypeptide binding]; other site
99598011296	phosphorylation site [posttranslational modification]
99598011297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598011298	ATP binding site [chemical binding]; other site
99598011299	Mg2+ binding site [ion binding]; other site
99598011300	G-X-G motif; other site
99598011301	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598011302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598011303	active site
99598011304	phosphorylation site [posttranslational modification]
99598011305	intermolecular recognition site; other site
99598011306	dimerization interface [polypeptide binding]; other site
99598011307	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598011308	Response regulator receiver domain; Region: Response_reg; pfam00072
99598011309	active site
99598011310	phosphorylation site [posttranslational modification]
99598011311	intermolecular recognition site; other site
99598011312	dimerization interface [polypeptide binding]; other site
99598011313	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
99598011314	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99598011315	metal binding site [ion binding]; metal-binding site
99598011316	active site
99598011317	I-site; other site
99598011318	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99598011319	Response regulator receiver domain; Region: Response_reg; pfam00072
99598011320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598011321	active site
99598011322	phosphorylation site [posttranslational modification]
99598011323	intermolecular recognition site; other site
99598011324	dimerization interface [polypeptide binding]; other site
99598011325	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
99598011326	dimer interface [polypeptide binding]; other site
99598011327	phosphorylation site [posttranslational modification]
99598011328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598011329	ATP binding site [chemical binding]; other site
99598011330	Mg2+ binding site [ion binding]; other site
99598011331	G-X-G motif; other site
99598011332	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
99598011333	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
99598011334	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
99598011335	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
99598011336	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598011337	Walker A motif; other site
99598011338	ATP binding site [chemical binding]; other site
99598011339	Walker B motif; other site
99598011340	negative regulator GrlR; Provisional; Region: PRK14051
99598011341	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
99598011342	RxxxH motif; other site
99598011343	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598011344	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598011345	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99598011346	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598011347	DNA binding residues [nucleotide binding]
99598011348	dimerization interface [polypeptide binding]; other site
99598011349	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
99598011350	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
99598011351	Family description; Region: UvrD_C_2; pfam13538
99598011352	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
99598011353	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
99598011354	NADP binding site [chemical binding]; other site
99598011355	active site
99598011356	putative substrate binding site [chemical binding]; other site
99598011357	Lysozyme family protein [General function prediction only]; Region: COG5526
99598011358	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598011359	binding surface
99598011360	TPR repeat; Region: TPR_11; pfam13414
99598011361	TPR motif; other site
99598011362	TPR repeat; Region: TPR_11; pfam13414
99598011363	TPR repeat; Region: TPR_11; pfam13414
99598011364	Uncharacterized conserved protein [Function unknown]; Region: COG0393
99598011365	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
99598011366	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
99598011367	putative DNA binding site [nucleotide binding]; other site
99598011368	putative Zn2+ binding site [ion binding]; other site
99598011369	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
99598011370	putative ABC transporter; Region: ycf24; CHL00085
99598011371	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
99598011372	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
99598011373	Walker A/P-loop; other site
99598011374	ATP binding site [chemical binding]; other site
99598011375	Q-loop/lid; other site
99598011376	ABC transporter signature motif; other site
99598011377	Walker B; other site
99598011378	D-loop; other site
99598011379	H-loop/switch region; other site
99598011380	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
99598011381	FeS assembly protein SufD; Region: sufD; TIGR01981
99598011382	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
99598011383	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
99598011384	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99598011385	catalytic residue [active]
99598011386	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598011387	putative active site [active]
99598011388	AAA ATPase domain; Region: AAA_16; pfam13191
99598011389	NACHT domain; Region: NACHT; pfam05729
99598011390	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598011391	structural tetrad; other site
99598011392	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598011393	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598011394	structural tetrad; other site
99598011395	FEZ-like protein; Region: FEZ; pfam07763
99598011396	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
99598011397	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
99598011398	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
99598011399	TPR repeat; Region: TPR_11; pfam13414
99598011400	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598011401	binding surface
99598011402	TPR motif; other site
99598011403	TPR repeat; Region: TPR_11; pfam13414
99598011404	TPR repeat; Region: TPR_11; pfam13414
99598011405	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598011406	binding surface
99598011407	TPR motif; other site
99598011408	TPR repeat; Region: TPR_11; pfam13414
99598011409	TPR repeat; Region: TPR_11; pfam13414
99598011410	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598011411	binding surface
99598011412	TPR motif; other site
99598011413	TPR repeat; Region: TPR_11; pfam13414
99598011414	Protein of unknown function (DUF1625); Region: DUF1625; pfam07787
99598011415	CAAX protease self-immunity; Region: Abi; pfam02517
99598011416	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
99598011417	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
99598011418	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
99598011419	metal-binding site [ion binding]
99598011420	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99598011421	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598011422	motif II; other site
99598011423	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
99598011424	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
99598011425	phosphopeptide binding site; other site
99598011426	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
99598011427	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
99598011428	putative NAD(P) binding site [chemical binding]; other site
99598011429	putative active site [active]
99598011430	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598011431	binding surface
99598011432	TPR motif; other site
99598011433	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
99598011434	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
99598011435	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99598011436	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
99598011437	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
99598011438	putative hydrophobic ligand binding site [chemical binding]; other site
99598011439	Lipoprotein NlpI, contains TPR repeats [General function prediction only]; Region: NlpI; COG4785
99598011440	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598011441	binding surface
99598011442	TPR motif; other site
99598011443	MEKHLA domain; Region: MEKHLA; pfam08670
99598011444	glycogen synthase; Provisional; Region: glgA; PRK00654
99598011445	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
99598011446	ADP-binding pocket [chemical binding]; other site
99598011447	homodimer interface [polypeptide binding]; other site
99598011448	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
99598011449	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
99598011450	domain interfaces; other site
99598011451	active site
99598011452	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
99598011453	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
99598011454	GUN4-like; Region: GUN4; pfam05419
99598011455	CHAT domain; Region: CHAT; cl17868
99598011456	putative lipid kinase; Reviewed; Region: PRK00861
99598011457	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
99598011458	PEGA domain; Region: PEGA; pfam08308
99598011459	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
99598011460	active site
99598011461	metal binding site [ion binding]; metal-binding site
99598011462	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
99598011463	BON domain; Region: BON; pfam04972
99598011464	Response regulator receiver domain; Region: Response_reg; pfam00072
99598011465	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598011466	active site
99598011467	phosphorylation site [posttranslational modification]
99598011468	intermolecular recognition site; other site
99598011469	dimerization interface [polypeptide binding]; other site
99598011470	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598011471	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598011472	ATP binding site [chemical binding]; other site
99598011473	Mg2+ binding site [ion binding]; other site
99598011474	G-X-G motif; other site
99598011475	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
99598011476	CHASE2 domain; Region: CHASE2; pfam05226
99598011477	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598011478	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598011479	dimer interface [polypeptide binding]; other site
99598011480	phosphorylation site [posttranslational modification]
99598011481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598011482	ATP binding site [chemical binding]; other site
99598011483	Mg2+ binding site [ion binding]; other site
99598011484	G-X-G motif; other site
99598011485	Response regulator receiver domain; Region: Response_reg; pfam00072
99598011486	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598011487	active site
99598011488	phosphorylation site [posttranslational modification]
99598011489	intermolecular recognition site; other site
99598011490	dimerization interface [polypeptide binding]; other site
99598011491	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
99598011492	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598011493	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598011494	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
99598011495	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598011496	GAF domain; Region: GAF_3; pfam13492
99598011497	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598011498	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598011499	dimer interface [polypeptide binding]; other site
99598011500	phosphorylation site [posttranslational modification]
99598011501	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598011502	ATP binding site [chemical binding]; other site
99598011503	Mg2+ binding site [ion binding]; other site
99598011504	G-X-G motif; other site
99598011505	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
99598011506	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598011507	active site
99598011508	phosphorylation site [posttranslational modification]
99598011509	intermolecular recognition site; other site
99598011510	dimerization interface [polypeptide binding]; other site
99598011511	PAS fold; Region: PAS_4; pfam08448
99598011512	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598011513	putative active site [active]
99598011514	heme pocket [chemical binding]; other site
99598011515	PAS domain S-box; Region: sensory_box; TIGR00229
99598011516	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598011517	PAS fold; Region: PAS_3; pfam08447
99598011518	putative active site [active]
99598011519	heme pocket [chemical binding]; other site
99598011520	PAS fold; Region: PAS_4; pfam08448
99598011521	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598011522	putative active site [active]
99598011523	heme pocket [chemical binding]; other site
99598011524	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598011525	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598011526	putative active site [active]
99598011527	heme pocket [chemical binding]; other site
99598011528	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598011529	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598011530	dimer interface [polypeptide binding]; other site
99598011531	phosphorylation site [posttranslational modification]
99598011532	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598011533	ATP binding site [chemical binding]; other site
99598011534	Mg2+ binding site [ion binding]; other site
99598011535	G-X-G motif; other site
99598011536	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598011537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598011538	active site
99598011539	phosphorylation site [posttranslational modification]
99598011540	intermolecular recognition site; other site
99598011541	dimerization interface [polypeptide binding]; other site
99598011542	Caspase domain; Region: Peptidase_C14; pfam00656
99598011543	AAA ATPase domain; Region: AAA_16; pfam13191
99598011544	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598011545	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598011546	structural tetrad; other site
99598011547	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598011548	structural tetrad; other site
99598011549	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598011550	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598011551	TPR motif; other site
99598011552	Transcriptional regulators [Transcription]; Region: MarR; COG1846
99598011553	MarR family; Region: MarR_2; pfam12802
99598011554	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
99598011555	4Fe-4S binding domain; Region: Fer4; pfam00037
99598011556	SCP-2 sterol transfer family; Region: SCP2; pfam02036
99598011557	Uncharacterized conserved protein [Function unknown]; Region: COG5464
99598011558	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598011559	Protein kinase domain; Region: Pkinase; pfam00069
99598011560	active site
99598011561	substrate binding site [chemical binding]; other site
99598011562	ATP binding site [chemical binding]; other site
99598011563	activation loop (A-loop); other site
99598011564	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
99598011565	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
99598011566	putative ligand binding site [chemical binding]; other site
99598011567	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
99598011568	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
99598011569	DDE superfamily endonuclease; Region: DDE_5; cl17874
99598011570	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
99598011571	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
99598011572	NACHT domain; Region: NACHT; pfam05729
99598011573	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
99598011574	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
99598011575	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
99598011576	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
99598011577	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879
99598011578	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
99598011579	Transposase; Region: DEDD_Tnp_IS110; pfam01548
99598011580	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
99598011581	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
99598011582	DDE superfamily endonuclease; Region: DDE_5; cl17874
99598011583	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
99598011584	Protein of unknown function (DUF433); Region: DUF433; cl01030
99598011585	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
99598011586	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
99598011587	PYR/PP interface [polypeptide binding]; other site
99598011588	dimer interface [polypeptide binding]; other site
99598011589	TPP binding site [chemical binding]; other site
99598011590	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
99598011591	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
99598011592	TPP-binding site [chemical binding]; other site
99598011593	dimer interface [polypeptide binding]; other site
99598011594	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
99598011595	H+ Antiporter protein; Region: 2A0121; TIGR00900
99598011596	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
99598011597	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
99598011598	C-terminal domain interface [polypeptide binding]; other site
99598011599	active site
99598011600	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
99598011601	active site
99598011602	N-terminal domain interface [polypeptide binding]; other site
99598011603	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598011604	putative active site [active]
99598011605	Predicted flavoprotein [General function prediction only]; Region: COG0431
99598011606	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
99598011607	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
99598011608	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598011609	Walker A motif; other site
99598011610	ATP binding site [chemical binding]; other site
99598011611	Walker B motif; other site
99598011612	arginine finger; other site
99598011613	Peptidase family M41; Region: Peptidase_M41; pfam01434
99598011614	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
99598011615	Peptidase family M23; Region: Peptidase_M23; pfam01551
99598011616	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
99598011617	Cytochrome c; Region: Cytochrom_C; cl11414
99598011618	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
99598011619	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
99598011620	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
99598011621	heme bL binding site [chemical binding]; other site
99598011622	interchain domain interface [polypeptide binding]; other site
99598011623	intrachain domain interface; other site
99598011624	heme bH binding site [chemical binding]; other site
99598011625	Qo binding site; other site
99598011626	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
99598011627	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
99598011628	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
99598011629	TrkA-N domain; Region: TrkA_N; pfam02254
99598011630	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
99598011631	putative hydrophobic ligand binding site [chemical binding]; other site
99598011632	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598011633	GAF domain; Region: GAF; pfam01590
99598011634	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598011635	GAF domain; Region: GAF; pfam01590
99598011636	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598011637	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598011638	dimer interface [polypeptide binding]; other site
99598011639	phosphorylation site [posttranslational modification]
99598011640	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598011641	ATP binding site [chemical binding]; other site
99598011642	Mg2+ binding site [ion binding]; other site
99598011643	G-X-G motif; other site
99598011644	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
99598011645	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
99598011646	active site
99598011647	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
99598011648	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
99598011649	NodB motif; other site
99598011650	active site
99598011651	catalytic site [active]
99598011652	metal binding site [ion binding]; metal-binding site
99598011653	Uncharacterized conserved protein [Function unknown]; Region: COG3334
99598011654	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
99598011655	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
99598011656	dimerization interface [polypeptide binding]; other site
99598011657	DPS ferroxidase diiron center [ion binding]; other site
99598011658	ion pore; other site
99598011659	ChaB; Region: ChaB; pfam06150
99598011660	Protein of unknown function (DUF2393); Region: DUF2393; pfam09624
99598011661	TIGR02588 family protein; Region: TIGR02588
99598011662	Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622
99598011663	CsbD-like; Region: CsbD; cl17424
99598011664	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
99598011665	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
99598011666	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
99598011667	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
99598011668	G1 box; other site
99598011669	GTP/Mg2+ binding site [chemical binding]; other site
99598011670	G2 box; other site
99598011671	Switch I region; other site
99598011672	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
99598011673	G3 box; other site
99598011674	Switch II region; other site
99598011675	G4 box; other site
99598011676	KGK domain; Region: KGK; pfam08872
99598011677	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
99598011678	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
99598011679	active site
99598011680	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
99598011681	Subunit I/III interface [polypeptide binding]; other site
99598011682	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
99598011683	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
99598011684	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
99598011685	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
99598011686	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
99598011687	Predicted membrane protein [Function unknown]; Region: COG4244
99598011688	Predicted membrane protein [Function unknown]; Region: COG4244
99598011689	Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229
99598011690	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
99598011691	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
99598011692	TAP-like protein; Region: Abhydrolase_4; pfam08386
99598011693	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
99598011694	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598011695	putative substrate translocation pore; other site
99598011696	AMIN domain; Region: AMIN; pfam11741
99598011697	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
99598011698	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99598011699	N-terminal plug; other site
99598011700	ligand-binding site [chemical binding]; other site
99598011701	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
99598011702	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
99598011703	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
99598011704	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
99598011705	DNA photolyase; Region: DNA_photolyase; pfam00875
99598011706	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
99598011707	Lipoxygenase; Region: Lipoxygenase; pfam00305
99598011708	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
99598011709	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
99598011710	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
99598011711	Core-2/I-Branching enzyme; Region: Branch; pfam02485
99598011712	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598011713	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598011714	active site
99598011715	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
99598011716	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598011717	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598011718	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598011719	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
99598011720	putative ADP-binding pocket [chemical binding]; other site
99598011721	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
99598011722	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
99598011723	Chain length determinant protein; Region: Wzz; pfam02706
99598011724	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
99598011725	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
99598011726	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99598011727	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
99598011728	Uncharacterized conserved protein [Function unknown]; Region: COG4748
99598011729	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
99598011730	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
99598011731	putative active site [active]
99598011732	ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187
99598011733	ATP-grasp domain; Region: ATP-grasp_4; cl17255
99598011734	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
99598011735	diiron binding motif [ion binding]; other site
99598011736	TM2 domain; Region: TM2; cl00984
99598011737	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
99598011738	Exonuclease VII small subunit [DNA replication, recombination, and repair]; Region: XseB; COG1722
99598011739	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
99598011740	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
99598011741	generic binding surface II; other site
99598011742	generic binding surface I; other site
99598011743	recombinase A; Provisional; Region: recA; PRK09354
99598011744	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
99598011745	hexamer interface [polypeptide binding]; other site
99598011746	Walker A motif; other site
99598011747	ATP binding site [chemical binding]; other site
99598011748	Walker B motif; other site
99598011749	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
99598011750	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
99598011751	phosphopeptide binding site; other site
99598011752	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598011753	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598011754	active site
99598011755	ATP binding site [chemical binding]; other site
99598011756	substrate binding site [chemical binding]; other site
99598011757	activation loop (A-loop); other site
99598011758	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598011759	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598011760	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598011761	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
99598011762	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
99598011763	inhibitor-cofactor binding pocket; inhibition site
99598011764	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598011765	catalytic residue [active]
99598011766	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
99598011767	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
99598011768	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
99598011769	metal binding site [ion binding]; metal-binding site
99598011770	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
99598011771	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
99598011772	NAD binding site [chemical binding]; other site
99598011773	dimerization interface [polypeptide binding]; other site
99598011774	product binding site; other site
99598011775	substrate binding site [chemical binding]; other site
99598011776	zinc binding site [ion binding]; other site
99598011777	catalytic residues [active]
99598011778	TPR repeat; Region: TPR_11; pfam13414
99598011779	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598011780	binding surface
99598011781	TPR motif; other site
99598011782	TPR repeat; Region: TPR_11; pfam13414
99598011783	TPR repeat; Region: TPR_11; pfam13414
99598011784	manganese transport protein MntH; Reviewed; Region: PRK00701
99598011785	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
99598011786	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
99598011787	putative DNA binding site [nucleotide binding]; other site
99598011788	dimerization interface [polypeptide binding]; other site
99598011789	putative Zn2+ binding site [ion binding]; other site
99598011790	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
99598011791	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
99598011792	metal-binding site [ion binding]
99598011793	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
99598011794	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
99598011795	metal-binding site [ion binding]
99598011796	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99598011797	Soluble P-type ATPase [General function prediction only]; Region: COG4087
99598011798	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
99598011799	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
99598011800	Walker A motif; other site
99598011801	ATP binding site [chemical binding]; other site
99598011802	Walker B motif; other site
99598011803	Response regulator receiver domain; Region: Response_reg; pfam00072
99598011804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598011805	active site
99598011806	phosphorylation site [posttranslational modification]
99598011807	intermolecular recognition site; other site
99598011808	dimerization interface [polypeptide binding]; other site
99598011809	NB-ARC domain; Region: NB-ARC; pfam00931
99598011810	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598011811	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598011812	TPR motif; other site
99598011813	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598011814	binding surface
99598011815	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598011816	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598011817	binding surface
99598011818	TPR motif; other site
99598011819	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598011820	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
99598011821	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
99598011822	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
99598011823	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
99598011824	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
99598011825	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
99598011826	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
99598011827	beta-phosphoglucomutase; Region: bPGM; TIGR01990
99598011828	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598011829	S-layer homology domain; Region: SLH; pfam00395
99598011830	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
99598011831	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
99598011832	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
99598011833	Walker A/P-loop; other site
99598011834	ATP binding site [chemical binding]; other site
99598011835	Q-loop/lid; other site
99598011836	ABC transporter signature motif; other site
99598011837	Walker B; other site
99598011838	D-loop; other site
99598011839	H-loop/switch region; other site
99598011840	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
99598011841	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
99598011842	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598011843	dimer interface [polypeptide binding]; other site
99598011844	conserved gate region; other site
99598011845	ABC-ATPase subunit interface; other site
99598011846	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
99598011847	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99598011848	DNA-binding site [nucleotide binding]; DNA binding site
99598011849	UTRA domain; Region: UTRA; pfam07702
99598011850	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
99598011851	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625
99598011852	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
99598011853	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598011854	Coenzyme A binding pocket [chemical binding]; other site
99598011855	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
99598011856	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
99598011857	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
99598011858	active site
99598011859	metal binding site [ion binding]; metal-binding site
99598011860	Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454
99598011861	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
99598011862	active site
99598011863	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
99598011864	Zn2+ binding site [ion binding]; other site
99598011865	Mg2+ binding site [ion binding]; other site
99598011866	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
99598011867	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
99598011868	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99598011869	Walker A/P-loop; other site
99598011870	ATP binding site [chemical binding]; other site
99598011871	Q-loop/lid; other site
99598011872	ABC transporter signature motif; other site
99598011873	Walker B; other site
99598011874	D-loop; other site
99598011875	H-loop/switch region; other site
99598011876	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
99598011877	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
99598011878	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598011879	Walker A/P-loop; other site
99598011880	ATP binding site [chemical binding]; other site
99598011881	Q-loop/lid; other site
99598011882	ABC transporter signature motif; other site
99598011883	Walker B; other site
99598011884	D-loop; other site
99598011885	H-loop/switch region; other site
99598011886	Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454
99598011887	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
99598011888	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
99598011889	active site
99598011890	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
99598011891	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
99598011892	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598011893	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598011894	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598011895	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598011896	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598011897	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598011898	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
99598011899	putative hexamer interface [polypeptide binding]; other site
99598011900	putative hexagonal pore; other site
99598011901	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
99598011902	Hexamer interface [polypeptide binding]; other site
99598011903	Hexagonal pore residue; other site
99598011904	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
99598011905	GIY-YIG motif/motif A; other site
99598011906	active site
99598011907	catalytic site [active]
99598011908	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
99598011909	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598011910	Protein of unknown function (DUF3137); Region: DUF3137; pfam11335
99598011911	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
99598011912	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598011913	substrate binding pocket [chemical binding]; other site
99598011914	membrane-bound complex binding site; other site
99598011915	hinge residues; other site
99598011916	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
99598011917	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
99598011918	Chromate transporter; Region: Chromate_transp; pfam02417
99598011919	Putative phosphatase (DUF442); Region: DUF442; cl17385
99598011920	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
99598011921	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
99598011922	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
99598011923	N-terminal domain interface [polypeptide binding]; other site
99598011924	dimer interface [polypeptide binding]; other site
99598011925	substrate binding pocket (H-site) [chemical binding]; other site
99598011926	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
99598011927	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598011928	membrane-bound complex binding site; other site
99598011929	hinge residues; other site
99598011930	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99598011931	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
99598011932	active site
99598011933	catalytic tetrad [active]
99598011934	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
99598011935	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598011936	membrane-bound complex binding site; other site
99598011937	hinge residues; other site
99598011938	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
99598011939	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
99598011940	dimer interface [polypeptide binding]; other site
99598011941	active site
99598011942	non-prolyl cis peptide bond; other site
99598011943	insertion regions; other site
99598011944	RRXRR protein; Region: RRXRR; pfam14239
99598011945	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
99598011946	hypothetical protein; Provisional; Region: PRK06208
99598011947	intersubunit interface [polypeptide binding]; other site
99598011948	active site
99598011949	Zn2+ binding site [ion binding]; other site
99598011950	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
99598011951	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598011952	substrate binding pocket [chemical binding]; other site
99598011953	membrane-bound complex binding site; other site
99598011954	hinge residues; other site
99598011955	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
99598011956	dimer interface [polypeptide binding]; other site
99598011957	FMN binding site [chemical binding]; other site
99598011958	NADPH bind site [chemical binding]; other site
99598011959	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
99598011960	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
99598011961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99598011962	NAD(P) binding site [chemical binding]; other site
99598011963	active site
99598011964	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
99598011965	substrate binding site [chemical binding]; other site
99598011966	active site
99598011967	ornithine carbamoyltransferase; Provisional; Region: PRK00779
99598011968	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
99598011969	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
99598011970	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
99598011971	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
99598011972	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
99598011973	Catalytic site [active]
99598011974	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
99598011975	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598011976	ATP binding site [chemical binding]; other site
99598011977	putative Mg++ binding site [ion binding]; other site
99598011978	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598011979	nucleotide binding region [chemical binding]; other site
99598011980	ATP-binding site [chemical binding]; other site
99598011981	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
99598011982	active site
99598011983	catalytic residues [active]
99598011984	DNA binding site [nucleotide binding]
99598011985	Int/Topo IB signature motif; other site
99598011986	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
99598011987	Transposase; Region: DEDD_Tnp_IS110; pfam01548
99598011988	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598011989	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
99598011990	Walker A/P-loop; other site
99598011991	ATP binding site [chemical binding]; other site
99598011992	Nucleoporin complex subunit 54; Region: Nup54; pfam13874
99598011993	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598011994	Walker B; other site
99598011995	D-loop; other site
99598011996	H-loop/switch region; other site
99598011997	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
99598011998	Cadmium resistance transporter; Region: Cad; pfam03596
99598011999	S-layer homology domain; Region: SLH; pfam00395
99598012000	S-layer homology domain; Region: SLH; pfam00395
99598012001	S-layer homology domain; Region: SLH; pfam00395
99598012002	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
99598012003	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598012004	putative active site [active]
99598012005	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598012006	putative active site [active]
99598012007	dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062
99598012008	DNA-sulfur modification-associated; Region: DndB; pfam14072
99598012009	DGQHR domain; Region: DGQHR; TIGR03187
99598012010	DNA-sulfur modification-associated; Region: DndB; cl17621
99598012011	hypothetical protein; Provisional; Region: PRK06850
99598012012	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
99598012013	Active Sites [active]
99598012014	Transposase IS200 like; Region: Y1_Tnp; pfam01797
99598012015	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
99598012016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598012017	Walker A/P-loop; other site
99598012018	ATP binding site [chemical binding]; other site
99598012019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598012020	ABC transporter signature motif; other site
99598012021	Walker B; other site
99598012022	D-loop; other site
99598012023	H-loop/switch region; other site
99598012024	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
99598012025	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
99598012026	muropeptide transporter; Validated; Region: ampG; cl17669
99598012027	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99598012028	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
99598012029	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598012030	Coenzyme A binding pocket [chemical binding]; other site
99598012031	HEAT repeats; Region: HEAT_2; pfam13646
99598012032	HEAT repeats; Region: HEAT_2; pfam13646
99598012033	HEAT repeats; Region: HEAT_2; pfam13646
99598012034	Cupin domain; Region: Cupin_2; cl17218
99598012035	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
99598012036	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
99598012037	CHAT domain; Region: CHAT; pfam12770
99598012038	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
99598012039	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598012040	binding surface
99598012041	TPR motif; other site
99598012042	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598012043	binding surface
99598012044	TPR motif; other site
99598012045	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598012046	binding surface
99598012047	TPR motif; other site
99598012048	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598012049	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598012050	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598012051	binding surface
99598012052	TPR motif; other site
99598012053	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598012054	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598012055	putative active site [active]
99598012056	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
99598012057	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
99598012058	protein-splicing catalytic site; other site
99598012059	thioester formation/cholesterol transfer; other site
99598012060	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
99598012061	Homing endonuclease; Region: Hom_end; pfam05204
99598012062	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
99598012063	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
99598012064	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
99598012065	protein-splicing catalytic site; other site
99598012066	thioester formation/cholesterol transfer; other site
99598012067	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
99598012068	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
99598012069	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
99598012070	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
99598012071	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
99598012072	AMP binding site [chemical binding]; other site
99598012073	metal binding site [ion binding]; metal-binding site
99598012074	active site
99598012075	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
99598012076	putative active site [active]
99598012077	transaldolase; Provisional; Region: PRK03903
99598012078	catalytic residue [active]
99598012079	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
99598012080	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
99598012081	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
99598012082	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
99598012083	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598012084	Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
99598012085	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
99598012086	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
99598012087	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99598012088	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
99598012089	catalytic triad [active]
99598012090	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
99598012091	Isochorismatase family; Region: Isochorismatase; pfam00857
99598012092	catalytic triad [active]
99598012093	conserved cis-peptide bond; other site
99598012094	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
99598012095	XisI protein; Region: XisI; pfam08869
99598012096	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598012097	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598012098	ligand binding site [chemical binding]; other site
99598012099	flexible hinge region; other site
99598012100	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
99598012101	hypothetical protein; Provisional; Region: PRK02509
99598012102	Uncharacterized conserved protein [Function unknown]; Region: COG1615
99598012103	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
99598012104	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
99598012105	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
99598012106	photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056
99598012107	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
99598012108	glutaminase; Provisional; Region: PRK00971
99598012109	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
99598012110	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
99598012111	EF-hand domain pair; Region: EF_hand_5; pfam13499
99598012112	Ca2+ binding site [ion binding]; other site
99598012113	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
99598012114	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
99598012115	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
99598012116	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
99598012117	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
99598012118	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
99598012119	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
99598012120	tartrate dehydrogenase; Region: TTC; TIGR02089
99598012121	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
99598012122	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
99598012123	homotetramer interface [polypeptide binding]; other site
99598012124	ligand binding site [chemical binding]; other site
99598012125	catalytic site [active]
99598012126	NAD binding site [chemical binding]; other site
99598012127	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
99598012128	Mechanosensitive ion channel; Region: MS_channel; pfam00924
99598012129	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598012130	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598012131	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598012132	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598012133	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
99598012134	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598012135	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598012136	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
99598012137	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
99598012138	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
99598012139	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
99598012140	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
99598012141	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598012142	Coenzyme A binding pocket [chemical binding]; other site
99598012143	amidase; Provisional; Region: PRK09201
99598012144	Amidase; Region: Amidase; cl11426
99598012145	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
99598012146	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
99598012147	KGK domain; Region: KGK; pfam08872
99598012148	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
99598012149	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
99598012150	catalytic residues [active]
99598012151	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598012152	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598012153	binding surface
99598012154	TPR motif; other site
99598012155	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598012156	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598012157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
99598012158	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
99598012159	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
99598012160	CHAT domain; Region: CHAT; cl17868
99598012161	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
99598012162	CHASE2 domain; Region: CHASE2; pfam05226
99598012163	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
99598012164	16S rRNA methyltransferase B; Provisional; Region: PRK14901
99598012165	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
99598012166	putative RNA binding site [nucleotide binding]; other site
99598012167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598012168	S-adenosylmethionine binding site [chemical binding]; other site
99598012169	tellurium resistance terB-like protein; Region: terB_like; cd07177
99598012170	metal binding site [ion binding]; metal-binding site
99598012171	Transglycosylase; Region: Transgly; pfam00912
99598012172	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
99598012173	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
99598012174	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
99598012175	catalytic center binding site [active]
99598012176	ATP binding site [chemical binding]; other site
99598012177	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
99598012178	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
99598012179	dimer interface [polypeptide binding]; other site
99598012180	ADP-ribose binding site [chemical binding]; other site
99598012181	active site
99598012182	nudix motif; other site
99598012183	metal binding site [ion binding]; metal-binding site
99598012184	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
99598012185	active site
99598012186	nucleophile elbow; other site
99598012187	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
99598012188	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
99598012189	E3 interaction surface; other site
99598012190	lipoyl attachment site [posttranslational modification]; other site
99598012191	e3 binding domain; Region: E3_binding; pfam02817
99598012192	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
99598012193	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
99598012194	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
99598012195	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
99598012196	acyl-activating enzyme (AAE) consensus motif; other site
99598012197	putative AMP binding site [chemical binding]; other site
99598012198	putative active site [active]
99598012199	putative CoA binding site [chemical binding]; other site
99598012200	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598012201	putative active site [active]
99598012202	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
99598012203	active site
99598012204	putative homodimer interface [polypeptide binding]; other site
99598012205	SAM binding site [chemical binding]; other site
99598012206	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
99598012207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598012208	S-adenosylmethionine binding site [chemical binding]; other site
99598012209	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
99598012210	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
99598012211	nucleotide binding pocket [chemical binding]; other site
99598012212	K-X-D-G motif; other site
99598012213	catalytic site [active]
99598012214	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
99598012215	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
99598012216	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
99598012217	Dimer interface [polypeptide binding]; other site
99598012218	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
99598012219	Fasciclin domain; Region: Fasciclin; pfam02469
99598012220	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
99598012221	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
99598012222	23S rRNA binding site [nucleotide binding]; other site
99598012223	L21 binding site [polypeptide binding]; other site
99598012224	L13 binding site [polypeptide binding]; other site
99598012225	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
99598012226	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598012227	substrate binding pocket [chemical binding]; other site
99598012228	membrane-bound complex binding site; other site
99598012229	hinge residues; other site
99598012230	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
99598012231	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
99598012232	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
99598012233	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
99598012234	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598012235	binding surface
99598012236	TPR repeat; Region: TPR_11; pfam13414
99598012237	TPR motif; other site
99598012238	TPR repeat; Region: TPR_11; pfam13414
99598012239	tyramine oxidase; Provisional; Region: tynA; PRK11504
99598012240	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
99598012241	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
99598012242	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
99598012243	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
99598012244	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99598012245	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
99598012246	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
99598012247	protein binding site [polypeptide binding]; other site
99598012248	polyphosphate kinase; Provisional; Region: PRK05443
99598012249	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
99598012250	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
99598012251	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
99598012252	putative domain interface [polypeptide binding]; other site
99598012253	putative active site [active]
99598012254	catalytic site [active]
99598012255	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
99598012256	putative domain interface [polypeptide binding]; other site
99598012257	putative active site [active]
99598012258	catalytic site [active]
99598012259	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
99598012260	putative active site [active]
99598012261	putative metal binding residues [ion binding]; other site
99598012262	signature motif; other site
99598012263	putative dimer interface [polypeptide binding]; other site
99598012264	putative phosphate binding site [ion binding]; other site
99598012265	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
99598012266	XisI protein; Region: XisI; pfam08869
99598012267	phosphoenolpyruvate synthase; Validated; Region: PRK06464
99598012268	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
99598012269	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
99598012270	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
99598012271	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
99598012272	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
99598012273	active site
99598012274	catalytic site [active]
99598012275	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467
99598012276	starch-binding site 2 [chemical binding]; other site
99598012277	starch-binding site 1 [chemical binding]; other site
99598012278	triacylglycerol lipase; Region: PLN02571
99598012279	tellurite resistance protein terB; Region: terB; cd07176
99598012280	putative metal binding site [ion binding]; other site
99598012281	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
99598012282	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598012283	Coenzyme A binding pocket [chemical binding]; other site
99598012284	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
99598012285	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
99598012286	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
99598012287	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
99598012288	generic binding surface II; other site
99598012289	ssDNA binding site; other site
99598012290	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598012291	ATP binding site [chemical binding]; other site
99598012292	putative Mg++ binding site [ion binding]; other site
99598012293	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598012294	nucleotide binding region [chemical binding]; other site
99598012295	ATP-binding site [chemical binding]; other site
99598012296	elongation factor Ts; Provisional; Region: tsf; PRK09377
99598012297	UBA/TS-N domain; Region: UBA; pfam00627
99598012298	Elongation factor TS; Region: EF_TS; pfam00889
99598012299	Elongation factor TS; Region: EF_TS; pfam00889
99598012300	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
99598012301	rRNA interaction site [nucleotide binding]; other site
99598012302	S8 interaction site; other site
99598012303	putative laminin-1 binding site; other site
99598012304	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
99598012305	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
99598012306	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
99598012307	Probable Catalytic site; other site
99598012308	metal-binding site
99598012309	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
99598012310	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598012311	binding surface
99598012312	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598012313	TPR motif; other site
99598012314	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598012315	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598012316	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598012317	binding surface
99598012318	TPR motif; other site
99598012319	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598012320	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598012321	binding surface
99598012322	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598012323	TPR motif; other site
99598012324	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598012325	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99598012326	active site
99598012327	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
99598012328	Fe-S cluster binding site [ion binding]; other site
99598012329	active site
99598012330	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
99598012331	active site
99598012332	dimer interface [polypeptide binding]; other site
99598012333	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
99598012334	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
99598012335	active site
99598012336	HIGH motif; other site
99598012337	dimer interface [polypeptide binding]; other site
99598012338	KMSKS motif; other site
99598012339	Transglycosylase; Region: Transgly; pfam00912
99598012340	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
99598012341	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
99598012342	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
99598012343	Protein kinase domain; Region: Pkinase; pfam00069
99598012344	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598012345	active site
99598012346	ATP binding site [chemical binding]; other site
99598012347	substrate binding site [chemical binding]; other site
99598012348	activation loop (A-loop); other site
99598012349	AAA ATPase domain; Region: AAA_16; pfam13191
99598012350	Predicted ATPase [General function prediction only]; Region: COG3899
99598012351	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598012352	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598012353	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598012354	ATP binding site [chemical binding]; other site
99598012355	Mg2+ binding site [ion binding]; other site
99598012356	G-X-G motif; other site
99598012357	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
99598012358	Short C-terminal domain; Region: SHOCT; pfam09851
99598012359	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
99598012360	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
99598012361	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
99598012362	Catalytic site [active]
99598012363	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
99598012364	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
99598012365	catalytic triad [active]
99598012366	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598012367	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598012368	active site
99598012369	ATP binding site [chemical binding]; other site
99598012370	substrate binding site [chemical binding]; other site
99598012371	activation loop (A-loop); other site
99598012372	RDD family; Region: RDD; pfam06271
99598012373	RDD family; Region: RDD; pfam06271
99598012374	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
99598012375	putative active cleft [active]
99598012376	dimerization interface [polypeptide binding]; other site
99598012377	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598012378	putative active site [active]
99598012379	Phosphotransferase enzyme family; Region: APH; pfam01636
99598012380	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
99598012381	active site
99598012382	substrate binding site [chemical binding]; other site
99598012383	ATP binding site [chemical binding]; other site
99598012384	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
99598012385	putative heme binding site [chemical binding]; other site
99598012386	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
99598012387	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598012388	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
99598012389	TPR motif; other site
99598012390	binding surface
99598012391	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
99598012392	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
99598012393	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
99598012394	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
99598012395	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598012396	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598012397	active site
99598012398	ATP binding site [chemical binding]; other site
99598012399	substrate binding site [chemical binding]; other site
99598012400	activation loop (A-loop); other site
99598012401	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598012402	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598012403	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598012404	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598012405	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598012406	putative active site [active]
99598012407	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
99598012408	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
99598012409	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
99598012410	lipoyl attachment site [posttranslational modification]; other site
99598012411	glycine dehydrogenase; Provisional; Region: PRK05367
99598012412	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
99598012413	tetramer interface [polypeptide binding]; other site
99598012414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598012415	catalytic residue [active]
99598012416	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
99598012417	tetramer interface [polypeptide binding]; other site
99598012418	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598012419	catalytic residue [active]
99598012420	Predicted integral membrane protein [Function unknown]; Region: COG5652
99598012421	Vinculin family; Region: Vinculin; pfam01044
99598012422	Tic20-like protein; Region: Tic20; pfam09685
99598012423	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
99598012424	putative active site [active]
99598012425	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
99598012426	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
99598012427	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
99598012428	motif 1; other site
99598012429	active site
99598012430	motif 2; other site
99598012431	motif 3; other site
99598012432	putative membrane fusion protein; Region: TIGR02828
99598012433	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
99598012434	GTP-binding protein YchF; Reviewed; Region: PRK09601
99598012435	YchF GTPase; Region: YchF; cd01900
99598012436	G1 box; other site
99598012437	GTP/Mg2+ binding site [chemical binding]; other site
99598012438	Switch I region; other site
99598012439	G2 box; other site
99598012440	Switch II region; other site
99598012441	G3 box; other site
99598012442	G4 box; other site
99598012443	G5 box; other site
99598012444	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
99598012445	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
99598012446	putative active site [active]
99598012447	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598012448	putative active site [active]
99598012449	XisI protein; Region: XisI; pfam08869
99598012450	XisH protein; Region: XisH; pfam08814
99598012451	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
99598012452	DNA-sulfur modification-associated; Region: DndB; pfam14072
99598012453	DGQHR domain; Region: DGQHR; TIGR03187
99598012454	magnesium chelatase subunit H; Provisional; Region: PRK12493
99598012455	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
99598012456	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
99598012457	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
99598012458	active site
99598012459	catalytic triad [active]
99598012460	oxyanion hole [active]
99598012461	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
99598012462	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
99598012463	Ligand Binding Site [chemical binding]; other site
99598012464	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598012465	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598012466	dimer interface [polypeptide binding]; other site
99598012467	phosphorylation site [posttranslational modification]
99598012468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598012469	ATP binding site [chemical binding]; other site
99598012470	Mg2+ binding site [ion binding]; other site
99598012471	G-X-G motif; other site
99598012472	Response regulator receiver domain; Region: Response_reg; pfam00072
99598012473	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598012474	active site
99598012475	phosphorylation site [posttranslational modification]
99598012476	intermolecular recognition site; other site
99598012477	dimerization interface [polypeptide binding]; other site
99598012478	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
99598012479	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
99598012480	TM-ABC transporter signature motif; other site
99598012481	PsaX family; Region: PsaX; pfam08078
99598012482	lipoyl synthase; Provisional; Region: PRK12928
99598012483	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598012484	FeS/SAM binding site; other site
99598012485	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598012486	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598012487	active site
99598012488	phosphorylation site [posttranslational modification]
99598012489	intermolecular recognition site; other site
99598012490	dimerization interface [polypeptide binding]; other site
99598012491	Protein kinase domain; Region: Pkinase; pfam00069
99598012492	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598012493	active site
99598012494	ATP binding site [chemical binding]; other site
99598012495	substrate binding site [chemical binding]; other site
99598012496	activation loop (A-loop); other site
99598012497	AAA ATPase domain; Region: AAA_16; pfam13191
99598012498	Predicted ATPase [General function prediction only]; Region: COG3899
99598012499	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598012500	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598012501	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598012502	dimer interface [polypeptide binding]; other site
99598012503	phosphorylation site [posttranslational modification]
99598012504	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598012505	ATP binding site [chemical binding]; other site
99598012506	Mg2+ binding site [ion binding]; other site
99598012507	G-X-G motif; other site
99598012508	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
99598012509	Cytochrome P450; Region: p450; pfam00067
99598012510	Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687
99598012511	substrate binding pocket [chemical binding]; other site
99598012512	substrate-Mg2+ binding site; other site
99598012513	aspartate-rich region 1; other site
99598012514	active site lid residues [active]
99598012515	aspartate-rich region 2; other site
99598012516	Cache domain; Region: Cache_1; pfam02743
99598012517	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598012518	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598012519	dimerization interface [polypeptide binding]; other site
99598012520	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598012521	dimer interface [polypeptide binding]; other site
99598012522	phosphorylation site [posttranslational modification]
99598012523	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598012524	ATP binding site [chemical binding]; other site
99598012525	Mg2+ binding site [ion binding]; other site
99598012526	G-X-G motif; other site
99598012527	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598012528	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598012529	active site
99598012530	phosphorylation site [posttranslational modification]
99598012531	intermolecular recognition site; other site
99598012532	dimerization interface [polypeptide binding]; other site
99598012533	Response regulator receiver domain; Region: Response_reg; pfam00072
99598012534	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598012535	active site
99598012536	phosphorylation site [posttranslational modification]
99598012537	intermolecular recognition site; other site
99598012538	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598012539	dimerization interface [polypeptide binding]; other site
99598012540	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598012541	dimer interface [polypeptide binding]; other site
99598012542	phosphorylation site [posttranslational modification]
99598012543	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598012544	ATP binding site [chemical binding]; other site
99598012545	Mg2+ binding site [ion binding]; other site
99598012546	G-X-G motif; other site
99598012547	Uncharacterized conserved protein [Function unknown]; Region: COG3287
99598012548	FIST N domain; Region: FIST; pfam08495
99598012549	FIST C domain; Region: FIST_C; pfam10442
99598012550	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598012551	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
99598012552	dimer interface [polypeptide binding]; other site
99598012553	phosphorylation site [posttranslational modification]
99598012554	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598012555	ATP binding site [chemical binding]; other site
99598012556	Mg2+ binding site [ion binding]; other site
99598012557	G-X-G motif; other site
99598012558	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598012559	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598012560	dimer interface [polypeptide binding]; other site
99598012561	phosphorylation site [posttranslational modification]
99598012562	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598012563	ATP binding site [chemical binding]; other site
99598012564	Mg2+ binding site [ion binding]; other site
99598012565	G-X-G motif; other site
99598012566	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
99598012567	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
99598012568	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
99598012569	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
99598012570	active site
99598012571	interdomain interaction site; other site
99598012572	putative metal-binding site [ion binding]; other site
99598012573	nucleotide binding site [chemical binding]; other site
99598012574	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
99598012575	domain I; other site
99598012576	phosphate binding site [ion binding]; other site
99598012577	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
99598012578	domain II; other site
99598012579	domain III; other site
99598012580	nucleotide binding site [chemical binding]; other site
99598012581	DNA binding groove [nucleotide binding]
99598012582	catalytic site [active]
99598012583	domain IV; other site
99598012584	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
99598012585	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
99598012586	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
99598012587	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
99598012588	Dehydroquinase class II; Region: DHquinase_II; pfam01220
99598012589	trimer interface [polypeptide binding]; other site
99598012590	active site
99598012591	dimer interface [polypeptide binding]; other site
99598012592	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
99598012593	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
99598012594	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
99598012595	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
99598012596	Zn2+ binding site [ion binding]; other site
99598012597	Mg2+ binding site [ion binding]; other site
99598012598	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598012599	putative active site [active]
99598012600	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99598012601	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99598012602	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
99598012603	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
99598012604	iron-sulfur cluster [ion binding]; other site
99598012605	[2Fe-2S] cluster binding site [ion binding]; other site
99598012606	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598012607	putative active site [active]
99598012608	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
99598012609	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
99598012610	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598012611	S-adenosylmethionine binding site [chemical binding]; other site
99598012612	Response regulator receiver domain; Region: Response_reg; pfam00072
99598012613	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598012614	active site
99598012615	phosphorylation site [posttranslational modification]
99598012616	intermolecular recognition site; other site
99598012617	dimerization interface [polypeptide binding]; other site
99598012618	GAF domain; Region: GAF; pfam01590
99598012619	GAF domain; Region: GAF_2; pfam13185
99598012620	haemagglutination activity domain; Region: Haemagg_act; pfam05860
99598012621	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
99598012622	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
99598012623	haemagglutination activity domain; Region: Haemagg_act; pfam05860
99598012624	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
99598012625	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
99598012626	haemagglutination activity domain; Region: Haemagg_act; pfam05860
99598012627	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
99598012628	haemagglutination activity domain; Region: Haemagg_act; pfam05860
99598012629	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
99598012630	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
99598012631	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
99598012632	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
99598012633	Surface antigen; Region: Bac_surface_Ag; pfam01103
99598012634	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
99598012635	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598012636	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598012637	TPR repeat; Region: TPR_11; pfam13414
99598012638	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598012639	TPR motif; other site
99598012640	binding surface
99598012641	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99598012642	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99598012643	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
99598012644	substrate binding pocket [chemical binding]; other site
99598012645	dimerization interface [polypeptide binding]; other site
99598012646	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
99598012647	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
99598012648	NADP binding site [chemical binding]; other site
99598012649	substrate binding site [chemical binding]; other site
99598012650	active site
99598012651	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
99598012652	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
99598012653	TROVE domain; Region: TROVE; pfam05731
99598012654	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
99598012655	metal ion-dependent adhesion site (MIDAS); other site
99598012656	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
99598012657	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
99598012658	quinone interaction residues [chemical binding]; other site
99598012659	active site
99598012660	catalytic residues [active]
99598012661	FMN binding site [chemical binding]; other site
99598012662	substrate binding site [chemical binding]; other site
99598012663	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598012664	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598012665	GAF domain; Region: GAF; pfam01590
99598012666	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598012667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598012668	ATP binding site [chemical binding]; other site
99598012669	Mg2+ binding site [ion binding]; other site
99598012670	G-X-G motif; other site
99598012671	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
99598012672	Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514
99598012673	active site
99598012674	dimer interface [polypeptide binding]; other site
99598012675	catalytic nucleophile [active]
99598012676	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598012677	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
99598012678	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
99598012679	Substrate binding site; other site
99598012680	Mg++ binding site; other site
99598012681	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
99598012682	active site
99598012683	substrate binding site [chemical binding]; other site
99598012684	CoA binding site [chemical binding]; other site
99598012685	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
99598012686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598012687	active site
99598012688	phosphorylation site [posttranslational modification]
99598012689	intermolecular recognition site; other site
99598012690	dimerization interface [polypeptide binding]; other site
99598012691	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
99598012692	Zn2+ binding site [ion binding]; other site
99598012693	Mg2+ binding site [ion binding]; other site
99598012694	Uncharacterized conserved protein [Function unknown]; Region: COG4121
99598012695	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
99598012696	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
99598012697	active site residue [active]
99598012698	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
99598012699	active site residue [active]
99598012700	FecR protein; Region: FecR; pfam04773
99598012701	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
99598012702	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
99598012703	histidinol-phosphate aminotransferase; Provisional; Region: PRK02610
99598012704	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99598012705	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598012706	homodimer interface [polypeptide binding]; other site
99598012707	catalytic residue [active]
99598012708	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
99598012709	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598012710	Coenzyme A binding pocket [chemical binding]; other site
99598012711	Response regulator receiver domain; Region: Response_reg; pfam00072
99598012712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598012713	active site
99598012714	phosphorylation site [posttranslational modification]
99598012715	intermolecular recognition site; other site
99598012716	dimerization interface [polypeptide binding]; other site
99598012717	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598012718	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598012719	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598012720	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598012721	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598012722	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598012723	dimer interface [polypeptide binding]; other site
99598012724	phosphorylation site [posttranslational modification]
99598012725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598012726	ATP binding site [chemical binding]; other site
99598012727	Mg2+ binding site [ion binding]; other site
99598012728	G-X-G motif; other site
99598012729	Response regulator receiver domain; Region: Response_reg; pfam00072
99598012730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598012731	active site
99598012732	phosphorylation site [posttranslational modification]
99598012733	intermolecular recognition site; other site
99598012734	dimerization interface [polypeptide binding]; other site
99598012735	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
99598012736	cyclase homology domain; Region: CHD; cd07302
99598012737	nucleotidyl binding site; other site
99598012738	metal binding site [ion binding]; metal-binding site
99598012739	dimer interface [polypeptide binding]; other site
99598012740	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
99598012741	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
99598012742	Walker A/P-loop; other site
99598012743	ATP binding site [chemical binding]; other site
99598012744	Q-loop/lid; other site
99598012745	ABC transporter signature motif; other site
99598012746	Walker B; other site
99598012747	D-loop; other site
99598012748	H-loop/switch region; other site
99598012749	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
99598012750	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598012751	dimer interface [polypeptide binding]; other site
99598012752	conserved gate region; other site
99598012753	putative PBP binding loops; other site
99598012754	ABC-ATPase subunit interface; other site
99598012755	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
99598012756	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598012757	dimer interface [polypeptide binding]; other site
99598012758	conserved gate region; other site
99598012759	putative PBP binding loops; other site
99598012760	ABC-ATPase subunit interface; other site
99598012761	PBP superfamily domain; Region: PBP_like_2; cl17296
99598012762	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
99598012763	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
99598012764	lipoprotein signal peptidase; Provisional; Region: PRK14787
99598012765	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
99598012766	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
99598012767	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
99598012768	phosphopeptide binding site; other site
99598012769	Transglycosylase; Region: Transgly; pfam00912
99598012770	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
99598012771	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
99598012772	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
99598012773	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
99598012774	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99598012775	active site
99598012776	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
99598012777	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598012778	dimer interface [polypeptide binding]; other site
99598012779	conserved gate region; other site
99598012780	putative PBP binding loops; other site
99598012781	ABC-ATPase subunit interface; other site
99598012782	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598012783	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
99598012784	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598012785	putative active site [active]
99598012786	amidophosphoribosyltransferase; Provisional; Region: PRK07349
99598012787	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
99598012788	active site
99598012789	tetramer interface [polypeptide binding]; other site
99598012790	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99598012791	active site
99598012792	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
99598012793	dimerization interface [polypeptide binding]; other site
99598012794	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
99598012795	thioester formation/cholesterol transfer; other site
99598012796	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
99598012797	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
99598012798	ATP binding site [chemical binding]; other site
99598012799	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
99598012800	dimerization interface [polypeptide binding]; other site
99598012801	ATP binding site [chemical binding]; other site
99598012802	Phycobilisome protein; Region: Phycobilisome; cl08227
99598012803	TRAM domain; Region: TRAM; pfam01938
99598012804	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
99598012805	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598012806	S-adenosylmethionine binding site [chemical binding]; other site
99598012807	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
99598012808	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
99598012809	ATP binding site [chemical binding]; other site
99598012810	Mg2+ binding site [ion binding]; other site
99598012811	G-X-G motif; other site
99598012812	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
99598012813	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
99598012814	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
99598012815	putative dimer interface [polypeptide binding]; other site
99598012816	putative anticodon binding site; other site
99598012817	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
99598012818	homodimer interface [polypeptide binding]; other site
99598012819	motif 1; other site
99598012820	motif 2; other site
99598012821	active site
99598012822	motif 3; other site
99598012823	transcriptional regulator SlyA; Provisional; Region: PRK03573
99598012824	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
99598012825	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99598012826	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598012827	active site
99598012828	phosphorylation site [posttranslational modification]
99598012829	intermolecular recognition site; other site
99598012830	dimerization interface [polypeptide binding]; other site
99598012831	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598012832	DNA binding residues [nucleotide binding]
99598012833	dimerization interface [polypeptide binding]; other site
99598012834	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
99598012835	oligomerisation interface [polypeptide binding]; other site
99598012836	mobile loop; other site
99598012837	roof hairpin; other site
99598012838	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
99598012839	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
99598012840	ring oligomerisation interface [polypeptide binding]; other site
99598012841	ATP/Mg binding site [chemical binding]; other site
99598012842	stacking interactions; other site
99598012843	hinge regions; other site
99598012844	AAA domain; Region: AAA_31; pfam13614
99598012845	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
99598012846	P-loop; other site
99598012847	Magnesium ion binding site [ion binding]; other site
99598012848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598012849	S-adenosylmethionine binding site [chemical binding]; other site
99598012850	Ubiquitin-like proteins; Region: UBQ; cl00155
99598012851	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
99598012852	putative active site [active]
99598012853	Response regulator receiver domain; Region: Response_reg; pfam00072
99598012854	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598012855	active site
99598012856	phosphorylation site [posttranslational modification]
99598012857	intermolecular recognition site; other site
99598012858	dimerization interface [polypeptide binding]; other site
99598012859	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598012860	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598012861	dimer interface [polypeptide binding]; other site
99598012862	phosphorylation site [posttranslational modification]
99598012863	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598012864	ATP binding site [chemical binding]; other site
99598012865	Mg2+ binding site [ion binding]; other site
99598012866	G-X-G motif; other site
99598012867	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
99598012868	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
99598012869	NAD(P) binding site [chemical binding]; other site
99598012870	catalytic residues [active]
99598012871	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
99598012872	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
99598012873	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
99598012874	Moco binding site; other site
99598012875	metal coordination site [ion binding]; other site
99598012876	ribosomal protein L32; Validated; Region: rpl32; CHL00152
99598012877	Caspase domain; Region: Peptidase_C14; pfam00656
99598012878	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
99598012879	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
99598012880	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
99598012881	transmembrane helices; other site
99598012882	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
99598012883	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
99598012884	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
99598012885	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
99598012886	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
99598012887	dihydrodipicolinate synthase; Region: dapA; TIGR00674
99598012888	dimer interface [polypeptide binding]; other site
99598012889	active site
99598012890	catalytic residue [active]
99598012891	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
99598012892	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
99598012893	trigger factor; Provisional; Region: tig; PRK01490
99598012894	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
99598012895	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
99598012896	Clp protease; Region: CLP_protease; pfam00574
99598012897	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
99598012898	oligomer interface [polypeptide binding]; other site
99598012899	active site residues [active]
99598012900	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
99598012901	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
99598012902	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
99598012903	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598012904	Walker A motif; other site
99598012905	ATP binding site [chemical binding]; other site
99598012906	Walker B motif; other site
99598012907	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
99598012908	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
99598012909	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
99598012910	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598012911	putative active site [active]
99598012912	Predicted transcriptional regulators [Transcription]; Region: COG1725
99598012913	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99598012914	DNA-binding site [nucleotide binding]; DNA binding site
99598012915	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
99598012916	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
99598012917	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
99598012918	RNA binding site [nucleotide binding]; other site
99598012919	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
99598012920	RNA binding site [nucleotide binding]; other site
99598012921	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
99598012922	RNA binding site [nucleotide binding]; other site
99598012923	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
99598012924	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598012925	oligomeric interface; other site
99598012926	putative active site [active]
99598012927	homodimer interface [polypeptide binding]; other site
99598012928	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
99598012929	putative active site [active]
99598012930	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598012931	oligomeric interface; other site
99598012932	putative active site [active]
99598012933	homodimer interface [polypeptide binding]; other site
99598012934	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
99598012935	putative active site [active]
99598012936	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
99598012937	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
99598012938	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
99598012939	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598012940	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
99598012941	Family description; Region: UvrD_C_2; pfam13538
99598012942	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
99598012943	putative active site [active]
99598012944	homotetrameric interface [polypeptide binding]; other site
99598012945	metal binding site [ion binding]; metal-binding site
99598012946	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
99598012947	DDE superfamily endonuclease; Region: DDE_5; cl17874
99598012948	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
99598012949	Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397
99598012950	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
99598012951	putative active site [active]
99598012952	putative metal binding site [ion binding]; other site
99598012953	quinolinate synthetase; Provisional; Region: PRK09375
99598012954	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
99598012955	aromatic amino acid transport protein; Region: araaP; TIGR00837
99598012956	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
99598012957	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99598012958	NAD(P) binding site [chemical binding]; other site
99598012959	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
99598012960	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
99598012961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99598012962	active site
99598012963	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
99598012964	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
99598012965	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
99598012966	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
99598012967	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
99598012968	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598012969	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598012970	active site
99598012971	Methyltransferase domain; Region: Methyltransf_11; pfam08241
99598012972	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
99598012973	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
99598012974	dimer interface [polypeptide binding]; other site
99598012975	catalytic triad [active]
99598012976	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704
99598012977	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598012978	HEAT repeats; Region: HEAT_2; pfam13646
99598012979	HEAT repeats; Region: HEAT_2; pfam13646
99598012980	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
99598012981	EamA-like transporter family; Region: EamA; pfam00892
99598012982	EamA-like transporter family; Region: EamA; pfam00892
99598012983	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
99598012984	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
99598012985	HD domain; Region: HD; pfam01966
99598012986	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870
99598012987	UbiA prenyltransferase family; Region: UbiA; pfam01040
99598012988	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
99598012989	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
99598012990	active site
99598012991	Zn binding site [ion binding]; other site
99598012992	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598012993	Methyltransferase domain; Region: Methyltransf_31; pfam13847
99598012994	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
99598012995	dimer interface [polypeptide binding]; other site
99598012996	motif 1; other site
99598012997	active site
99598012998	motif 2; other site
99598012999	motif 3; other site
99598013000	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
99598013001	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598013002	putative active site [active]
99598013003	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
99598013004	G1 box; other site
99598013005	GTP/Mg2+ binding site [chemical binding]; other site
99598013006	G2 box; other site
99598013007	Switch I region; other site
99598013008	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598013009	non-specific DNA binding site [nucleotide binding]; other site
99598013010	salt bridge; other site
99598013011	sequence-specific DNA binding site [nucleotide binding]; other site
99598013012	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
99598013013	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
99598013014	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
99598013015	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
99598013016	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99598013017	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598013018	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
99598013019	Walker A/P-loop; other site
99598013020	ATP binding site [chemical binding]; other site
99598013021	Q-loop/lid; other site
99598013022	ABC transporter signature motif; other site
99598013023	Walker B; other site
99598013024	D-loop; other site
99598013025	H-loop/switch region; other site
99598013026	nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933
99598013027	Probable zinc-binding domain; Region: zf-trcl; pfam13451
99598013028	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
99598013029	EVE domain; Region: EVE; cl00728
99598013030	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598013031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598013032	active site
99598013033	phosphorylation site [posttranslational modification]
99598013034	intermolecular recognition site; other site
99598013035	dimerization interface [polypeptide binding]; other site
99598013036	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99598013037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598013038	active site
99598013039	phosphorylation site [posttranslational modification]
99598013040	intermolecular recognition site; other site
99598013041	dimerization interface [polypeptide binding]; other site
99598013042	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99598013043	DNA binding site [nucleotide binding]
99598013044	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
99598013045	putative binding surface; other site
99598013046	active site
99598013047	Response regulator receiver domain; Region: Response_reg; pfam00072
99598013048	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598013049	active site
99598013050	phosphorylation site [posttranslational modification]
99598013051	intermolecular recognition site; other site
99598013052	dimerization interface [polypeptide binding]; other site
99598013053	Response regulator receiver domain; Region: Response_reg; pfam00072
99598013054	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598013055	active site
99598013056	phosphorylation site [posttranslational modification]
99598013057	intermolecular recognition site; other site
99598013058	dimerization interface [polypeptide binding]; other site
99598013059	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
99598013060	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598013061	putative active site [active]
99598013062	heme pocket [chemical binding]; other site
99598013063	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598013064	dimer interface [polypeptide binding]; other site
99598013065	phosphorylation site [posttranslational modification]
99598013066	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598013067	ATP binding site [chemical binding]; other site
99598013068	Mg2+ binding site [ion binding]; other site
99598013069	G-X-G motif; other site
99598013070	Response regulator receiver domain; Region: Response_reg; pfam00072
99598013071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598013072	active site
99598013073	phosphorylation site [posttranslational modification]
99598013074	intermolecular recognition site; other site
99598013075	dimerization interface [polypeptide binding]; other site
99598013076	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598013077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598013078	active site
99598013079	phosphorylation site [posttranslational modification]
99598013080	intermolecular recognition site; other site
99598013081	dimerization interface [polypeptide binding]; other site
99598013082	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99598013083	Ligand Binding Site [chemical binding]; other site
99598013084	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
99598013085	nickel binding site [ion binding]; other site
99598013086	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
99598013087	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
99598013088	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
99598013089	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
99598013090	substrate-cofactor binding pocket; other site
99598013091	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598013092	catalytic residue [active]
99598013093	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
99598013094	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99598013095	catalytic loop [active]
99598013096	iron binding site [ion binding]; other site
99598013097	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
99598013098	Catalytic site; other site
99598013099	Staphylococcal nuclease homologue; Region: SNase; pfam00565
99598013100	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
99598013101	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
99598013102	active site
99598013103	dimerization interface [polypeptide binding]; other site
99598013104	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
99598013105	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99598013106	HSP70 interaction site [polypeptide binding]; other site
99598013107	TPR repeat; Region: TPR_11; pfam13414
99598013108	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013109	binding surface
99598013110	TPR motif; other site
99598013111	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598013112	GAF domain; Region: GAF; pfam01590
99598013113	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598013114	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598013115	dimer interface [polypeptide binding]; other site
99598013116	phosphorylation site [posttranslational modification]
99598013117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598013118	ATP binding site [chemical binding]; other site
99598013119	Mg2+ binding site [ion binding]; other site
99598013120	G-X-G motif; other site
99598013121	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598013122	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598013123	putative active site [active]
99598013124	heme pocket [chemical binding]; other site
99598013125	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598013126	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598013127	putative active site [active]
99598013128	heme pocket [chemical binding]; other site
99598013129	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598013130	putative active site [active]
99598013131	heme pocket [chemical binding]; other site
99598013132	PAS domain S-box; Region: sensory_box; TIGR00229
99598013133	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598013134	putative active site [active]
99598013135	heme pocket [chemical binding]; other site
99598013136	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
99598013137	PAS domain; Region: PAS; smart00091
99598013138	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598013139	dimer interface [polypeptide binding]; other site
99598013140	phosphorylation site [posttranslational modification]
99598013141	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598013142	ATP binding site [chemical binding]; other site
99598013143	Mg2+ binding site [ion binding]; other site
99598013144	G-X-G motif; other site
99598013145	Response regulator receiver domain; Region: Response_reg; pfam00072
99598013146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598013147	active site
99598013148	phosphorylation site [posttranslational modification]
99598013149	intermolecular recognition site; other site
99598013150	dimerization interface [polypeptide binding]; other site
99598013151	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598013152	phosphorylation site [posttranslational modification]
99598013153	Response regulator receiver domain; Region: Response_reg; pfam00072
99598013154	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598013155	active site
99598013156	phosphorylation site [posttranslational modification]
99598013157	intermolecular recognition site; other site
99598013158	dimerization interface [polypeptide binding]; other site
99598013159	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598013160	putative active site [active]
99598013161	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
99598013162	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
99598013163	dimer interface [polypeptide binding]; other site
99598013164	motif 1; other site
99598013165	active site
99598013166	motif 2; other site
99598013167	motif 3; other site
99598013168	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
99598013169	putative active site [active]
99598013170	heme pocket [chemical binding]; other site
99598013171	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
99598013172	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
99598013173	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
99598013174	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
99598013175	Walker A/P-loop; other site
99598013176	ATP binding site [chemical binding]; other site
99598013177	Q-loop/lid; other site
99598013178	ABC transporter signature motif; other site
99598013179	Walker B; other site
99598013180	D-loop; other site
99598013181	H-loop/switch region; other site
99598013182	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
99598013183	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
99598013184	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
99598013185	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
99598013186	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99598013187	catalytic residue [active]
99598013188	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
99598013189	proposed catalytic triad [active]
99598013190	active site nucleophile [active]
99598013191	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598013192	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598013193	GTP-binding protein LepA; Provisional; Region: PRK05433
99598013194	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
99598013195	G1 box; other site
99598013196	putative GEF interaction site [polypeptide binding]; other site
99598013197	GTP/Mg2+ binding site [chemical binding]; other site
99598013198	Switch I region; other site
99598013199	G2 box; other site
99598013200	G3 box; other site
99598013201	Switch II region; other site
99598013202	G4 box; other site
99598013203	G5 box; other site
99598013204	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
99598013205	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
99598013206	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
99598013207	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598013208	GAF domain; Region: GAF_3; pfam13492
99598013209	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598013210	dimer interface [polypeptide binding]; other site
99598013211	phosphorylation site [posttranslational modification]
99598013212	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598013213	ATP binding site [chemical binding]; other site
99598013214	Mg2+ binding site [ion binding]; other site
99598013215	G-X-G motif; other site
99598013216	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
99598013217	NifU-like domain; Region: NifU; pfam01106
99598013218	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
99598013219	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
99598013220	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
99598013221	putative active site [active]
99598013222	catalytic site [active]
99598013223	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598013224	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598013225	active site
99598013226	ATP binding site [chemical binding]; other site
99598013227	substrate binding site [chemical binding]; other site
99598013228	activation loop (A-loop); other site
99598013229	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598013230	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598013231	active site
99598013232	ATP binding site [chemical binding]; other site
99598013233	substrate binding site [chemical binding]; other site
99598013234	activation loop (A-loop); other site
99598013235	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598013236	structural tetrad; other site
99598013237	PQQ-like domain; Region: PQQ_2; pfam13360
99598013238	M28 Zn-Peptidases; Region: M28_like_1; cd05640
99598013239	Peptidase family M28; Region: Peptidase_M28; pfam04389
99598013240	metal binding site [ion binding]; metal-binding site
99598013241	Uncharacterized conserved protein [Function unknown]; Region: COG2836
99598013242	Predicted membrane protein [Function unknown]; Region: COG2717
99598013243	YtkA-like; Region: YtkA; pfam13115
99598013244	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
99598013245	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
99598013246	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
99598013247	NAD binding site [chemical binding]; other site
99598013248	homodimer interface [polypeptide binding]; other site
99598013249	active site
99598013250	substrate binding site [chemical binding]; other site
99598013251	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99598013252	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598013253	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598013254	Walker A/P-loop; other site
99598013255	ATP binding site [chemical binding]; other site
99598013256	Q-loop/lid; other site
99598013257	ABC transporter signature motif; other site
99598013258	Walker B; other site
99598013259	D-loop; other site
99598013260	H-loop/switch region; other site
99598013261	flavoprotein, HI0933 family; Region: TIGR00275
99598013262	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
99598013263	Rubredoxin [Energy production and conversion]; Region: COG1773
99598013264	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
99598013265	iron binding site [ion binding]; other site
99598013266	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
99598013267	hydrophobic ligand binding site; other site
99598013268	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
99598013269	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
99598013270	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
99598013271	nudix motif; other site
99598013272	Domain of unknown function DUF59; Region: DUF59; pfam01883
99598013273	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
99598013274	HEAT repeats; Region: HEAT_2; pfam13646
99598013275	HEAT repeats; Region: HEAT_2; pfam13646
99598013276	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
99598013277	protein binding surface [polypeptide binding]; other site
99598013278	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
99598013279	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
99598013280	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
99598013281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
99598013282	putative oxidoreductase; Provisional; Region: PRK08275
99598013283	L-aspartate oxidase; Provisional; Region: PRK06175
99598013284	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
99598013285	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598013286	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598013287	active site
99598013288	phosphorylation site [posttranslational modification]
99598013289	intermolecular recognition site; other site
99598013290	dimerization interface [polypeptide binding]; other site
99598013291	PAS domain S-box; Region: sensory_box; TIGR00229
99598013292	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598013293	putative active site [active]
99598013294	heme pocket [chemical binding]; other site
99598013295	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598013296	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598013297	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598013298	GAF domain; Region: GAF; pfam01590
99598013299	PAS domain S-box; Region: sensory_box; TIGR00229
99598013300	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598013301	putative active site [active]
99598013302	heme pocket [chemical binding]; other site
99598013303	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598013304	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598013305	PAS fold; Region: PAS_3; pfam08447
99598013306	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598013307	putative active site [active]
99598013308	heme pocket [chemical binding]; other site
99598013309	PAS fold; Region: PAS_4; pfam08448
99598013310	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598013311	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598013312	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598013313	dimer interface [polypeptide binding]; other site
99598013314	phosphorylation site [posttranslational modification]
99598013315	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598013316	ATP binding site [chemical binding]; other site
99598013317	Mg2+ binding site [ion binding]; other site
99598013318	G-X-G motif; other site
99598013319	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598013320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598013321	active site
99598013322	phosphorylation site [posttranslational modification]
99598013323	intermolecular recognition site; other site
99598013324	dimerization interface [polypeptide binding]; other site
99598013325	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
99598013326	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
99598013327	RNase E interface [polypeptide binding]; other site
99598013328	trimer interface [polypeptide binding]; other site
99598013329	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
99598013330	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
99598013331	RNase E interface [polypeptide binding]; other site
99598013332	trimer interface [polypeptide binding]; other site
99598013333	active site
99598013334	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
99598013335	putative nucleic acid binding region [nucleotide binding]; other site
99598013336	G-X-X-G motif; other site
99598013337	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
99598013338	RNA binding site [nucleotide binding]; other site
99598013339	domain interface; other site
99598013340	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
99598013341	SNF2 Helicase protein; Region: DUF3670; pfam12419
99598013342	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
99598013343	thioester formation/cholesterol transfer; other site
99598013344	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
99598013345	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
99598013346	protein-splicing catalytic site; other site
99598013347	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
99598013348	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598013349	putative Mg++ binding site [ion binding]; other site
99598013350	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598013351	nucleotide binding region [chemical binding]; other site
99598013352	ATP-binding site [chemical binding]; other site
99598013353	AAA ATPase domain; Region: AAA_16; pfam13191
99598013354	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013355	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013356	TPR motif; other site
99598013357	binding surface
99598013358	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013359	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013360	TIR domain; Region: TIR_2; pfam13676
99598013361	Uncharacterized conserved protein [Function unknown]; Region: COG4279
99598013362	photosystem II 44 kDa protein; Region: psbC; CHL00035
99598013363	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
99598013364	photosystem II protein D2; Region: psbD; CHL00004
99598013365	pheophytin binding site; other site
99598013366	chlorophyll binding site; other site
99598013367	quinone binding site; other site
99598013368	Fe binding site [ion binding]; other site
99598013369	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
99598013370	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598013371	putative active site [active]
99598013372	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
99598013373	active site
99598013374	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
99598013375	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
99598013376	dimer interface [polypeptide binding]; other site
99598013377	active site
99598013378	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
99598013379	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
99598013380	CHASE2 domain; Region: CHASE2; pfam05226
99598013381	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
99598013382	cyclase homology domain; Region: CHD; cd07302
99598013383	nucleotidyl binding site; other site
99598013384	metal binding site [ion binding]; metal-binding site
99598013385	dimer interface [polypeptide binding]; other site
99598013386	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598013387	putative active site [active]
99598013388	TPR repeat; Region: TPR_11; pfam13414
99598013389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013390	binding surface
99598013391	TPR motif; other site
99598013392	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
99598013393	putative chaperone; Provisional; Region: PRK11678
99598013394	nucleotide binding site [chemical binding]; other site
99598013395	putative NEF/HSP70 interaction site [polypeptide binding]; other site
99598013396	SBD interface [polypeptide binding]; other site
99598013397	HNH endonuclease; Region: HNH_2; pfam13391
99598013398	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
99598013399	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
99598013400	DnaJ domain; Region: DnaJ; pfam00226
99598013401	HSP70 interaction site [polypeptide binding]; other site
99598013402	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013403	binding surface
99598013404	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598013405	TPR motif; other site
99598013406	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
99598013407	TPR repeat; Region: TPR_11; pfam13414
99598013408	TPR motif; other site
99598013409	binding surface
99598013410	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598013411	BT1 family; Region: BT1; pfam03092
99598013412	putative substrate translocation pore; other site
99598013413	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
99598013414	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
99598013415	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
99598013416	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
99598013417	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
99598013418	NAD(P) binding site [chemical binding]; other site
99598013419	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
99598013420	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598013421	FeS/SAM binding site; other site
99598013422	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
99598013423	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
99598013424	ATP-grasp domain; Region: ATP-grasp_4; cl17255
99598013425	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99598013426	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598013427	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598013428	Walker A/P-loop; other site
99598013429	ATP binding site [chemical binding]; other site
99598013430	Q-loop/lid; other site
99598013431	ABC transporter signature motif; other site
99598013432	Walker B; other site
99598013433	D-loop; other site
99598013434	H-loop/switch region; other site
99598013435	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
99598013436	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
99598013437	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598013438	ATP binding site [chemical binding]; other site
99598013439	putative Mg++ binding site [ion binding]; other site
99598013440	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598013441	nucleotide binding region [chemical binding]; other site
99598013442	ATP-binding site [chemical binding]; other site
99598013443	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99598013444	active site
99598013445	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
99598013446	DNA protecting protein DprA; Region: dprA; TIGR00732
99598013447	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598013448	PemK-like protein; Region: PemK; pfam02452
99598013449	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
99598013450	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598013451	Coenzyme A binding pocket [chemical binding]; other site
99598013452	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
99598013453	septum formation inhibitor; Reviewed; Region: minC; PRK00513
99598013454	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
99598013455	septum site-determining protein MinD; Region: minD_bact; TIGR01968
99598013456	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
99598013457	Switch I; other site
99598013458	Switch II; other site
99598013459	cell division topological specificity factor MinE; Provisional; Region: PRK13988
99598013460	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
99598013461	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
99598013462	putative active site [active]
99598013463	substrate binding site [chemical binding]; other site
99598013464	putative cosubstrate binding site; other site
99598013465	catalytic site [active]
99598013466	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
99598013467	substrate binding site [chemical binding]; other site
99598013468	photosystem I subunit VII; Region: psaC; CHL00065
99598013469	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
99598013470	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
99598013471	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
99598013472	glutaminase active site [active]
99598013473	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
99598013474	dimer interface [polypeptide binding]; other site
99598013475	active site
99598013476	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
99598013477	dimer interface [polypeptide binding]; other site
99598013478	active site
99598013479	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598013480	putative active site [active]
99598013481	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
99598013482	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
99598013483	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598013484	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598013485	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
99598013486	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598013487	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598013488	active site
99598013489	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
99598013490	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598013491	active site
99598013492	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598013493	putative active site [active]
99598013494	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598013495	putative active site [active]
99598013496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598013497	S-adenosylmethionine binding site [chemical binding]; other site
99598013498	UbiA prenyltransferase family; Region: UbiA; pfam01040
99598013499	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382
99598013500	TPR repeat; Region: TPR_11; pfam13414
99598013501	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013502	binding surface
99598013503	TPR motif; other site
99598013504	TPR repeat; Region: TPR_11; pfam13414
99598013505	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598013506	putative active site [active]
99598013507	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598013508	putative active site [active]
99598013509	XisI protein; Region: XisI; pfam08869
99598013510	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
99598013511	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
99598013512	active site
99598013513	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
99598013514	AMP-binding enzyme; Region: AMP-binding; pfam00501
99598013515	acyl-activating enzyme (AAE) consensus motif; other site
99598013516	AMP binding site [chemical binding]; other site
99598013517	Phosphopantetheine attachment site; Region: PP-binding; cl09936
99598013518	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
99598013519	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99598013520	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598013521	oligomeric interface; other site
99598013522	putative active site [active]
99598013523	homodimer interface [polypeptide binding]; other site
99598013524	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
99598013525	E3 interaction surface; other site
99598013526	lipoyl attachment site [posttranslational modification]; other site
99598013527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013528	TPR motif; other site
99598013529	TPR repeat; Region: TPR_11; pfam13414
99598013530	binding surface
99598013531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598013532	S-adenosylmethionine binding site [chemical binding]; other site
99598013533	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382
99598013534	UbiA prenyltransferase family; Region: UbiA; pfam01040
99598013535	TPR repeat; Region: TPR_11; pfam13414
99598013536	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013537	binding surface
99598013538	TPR motif; other site
99598013539	TPR repeat; Region: TPR_11; pfam13414
99598013540	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598013541	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598013542	Methyltransferase domain; Region: Methyltransf_24; pfam13578
99598013543	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
99598013544	active site
99598013545	oxyanion hole [active]
99598013546	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
99598013547	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
99598013548	TPR repeat; Region: TPR_11; pfam13414
99598013549	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013550	binding surface
99598013551	TPR motif; other site
99598013552	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
99598013553	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013554	TPR motif; other site
99598013555	TPR repeat; Region: TPR_11; pfam13414
99598013556	binding surface
99598013557	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013558	binding surface
99598013559	TPR repeat; Region: TPR_11; pfam13414
99598013560	TPR motif; other site
99598013561	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
99598013562	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
99598013563	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
99598013564	Walker A/P-loop; other site
99598013565	ATP binding site [chemical binding]; other site
99598013566	Q-loop/lid; other site
99598013567	ABC transporter signature motif; other site
99598013568	Walker B; other site
99598013569	D-loop; other site
99598013570	H-loop/switch region; other site
99598013571	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
99598013572	putative carbohydrate binding site [chemical binding]; other site
99598013573	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
99598013574	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598013575	active site
99598013576	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598013577	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598013578	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
99598013579	ligand-binding site [chemical binding]; other site
99598013580	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598013581	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598013582	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598013583	active site
99598013584	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
99598013585	putative hydrophobic ligand binding site [chemical binding]; other site
99598013586	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
99598013587	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
99598013588	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
99598013589	B12 binding site [chemical binding]; other site
99598013590	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598013591	FeS/SAM binding site; other site
99598013592	Uncharacterized conserved protein [Function unknown]; Region: COG4095
99598013593	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598013594	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
99598013595	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
99598013596	Tetramer interface [polypeptide binding]; other site
99598013597	active site
99598013598	FMN-binding site [chemical binding]; other site
99598013599	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
99598013600	protein I interface; other site
99598013601	D2 interface; other site
99598013602	protein T interface; other site
99598013603	chlorophyll binding site; other site
99598013604	beta carotene binding site; other site
99598013605	pheophytin binding site; other site
99598013606	manganese-stabilizing polypeptide interface; other site
99598013607	CP43 interface; other site
99598013608	protein L interface; other site
99598013609	oxygen evolving complex binding site; other site
99598013610	bromide binding site; other site
99598013611	quinone binding site; other site
99598013612	Fe binding site [ion binding]; other site
99598013613	core light harvesting interface; other site
99598013614	cytochrome b559 alpha subunit interface; other site
99598013615	cytochrome c-550 interface; other site
99598013616	protein J interface; other site
99598013617	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
99598013618	nucleotide binding site/active site [active]
99598013619	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
99598013620	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
99598013621	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598013622	Walker A motif; other site
99598013623	ATP binding site [chemical binding]; other site
99598013624	Walker B motif; other site
99598013625	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
99598013626	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598013627	oligomeric interface; other site
99598013628	putative active site [active]
99598013629	homodimer interface [polypeptide binding]; other site
99598013630	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
99598013631	Predicted membrane protein [Function unknown]; Region: COG2323
99598013632	adenylosuccinate lyase; Provisional; Region: PRK07380
99598013633	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
99598013634	tetramer interface [polypeptide binding]; other site
99598013635	active site
99598013636	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
99598013637	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
99598013638	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
99598013639	Ferrochelatase; Region: Ferrochelatase; pfam00762
99598013640	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
99598013641	active site
99598013642	C-terminal domain interface [polypeptide binding]; other site
99598013643	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
99598013644	active site
99598013645	N-terminal domain interface [polypeptide binding]; other site
99598013646	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598013647	S-adenosylmethionine binding site [chemical binding]; other site
99598013648	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598013649	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
99598013650	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
99598013651	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
99598013652	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
99598013653	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
99598013654	AAA domain; Region: AAA_17; pfam13207
99598013655	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
99598013656	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
99598013657	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
99598013658	B12 binding site [chemical binding]; other site
99598013659	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598013660	FeS/SAM binding site; other site
99598013661	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
99598013662	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
99598013663	heterotetramer interface [polypeptide binding]; other site
99598013664	active site pocket [active]
99598013665	cleavage site
99598013666	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
99598013667	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
99598013668	GatB domain; Region: GatB_Yqey; smart00845
99598013669	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013670	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013671	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013672	binding surface
99598013673	TPR motif; other site
99598013674	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013675	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013676	TPR motif; other site
99598013677	binding surface
99598013678	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013679	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013680	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013681	binding surface
99598013682	TPR motif; other site
99598013683	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013684	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013685	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013686	binding surface
99598013687	TPR motif; other site
99598013688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
99598013689	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
99598013690	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
99598013691	active site residue [active]
99598013692	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
99598013693	active site residue [active]
99598013694	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
99598013695	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
99598013696	putative acyl-acceptor binding pocket; other site
99598013697	Putative phosphatase (DUF442); Region: DUF442; cl17385
99598013698	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
99598013699	Fasciclin domain; Region: Fasciclin; pfam02469
99598013700	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
99598013701	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
99598013702	CheB methylesterase; Region: CheB_methylest; pfam01339
99598013703	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
99598013704	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
99598013705	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598013706	S-adenosylmethionine binding site [chemical binding]; other site
99598013707	PAS fold; Region: PAS_4; pfam08448
99598013708	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598013709	putative active site [active]
99598013710	heme pocket [chemical binding]; other site
99598013711	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598013712	PAS domain; Region: PAS_9; pfam13426
99598013713	putative active site [active]
99598013714	heme pocket [chemical binding]; other site
99598013715	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598013716	oligomeric interface; other site
99598013717	putative active site [active]
99598013718	homodimer interface [polypeptide binding]; other site
99598013719	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
99598013720	transketolase; Region: PLN02790
99598013721	TPP-binding site [chemical binding]; other site
99598013722	dimer interface [polypeptide binding]; other site
99598013723	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
99598013724	PYR/PP interface [polypeptide binding]; other site
99598013725	dimer interface [polypeptide binding]; other site
99598013726	TPP binding site [chemical binding]; other site
99598013727	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
99598013728	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
99598013729	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
99598013730	dimer interface [polypeptide binding]; other site
99598013731	active site
99598013732	acyl carrier protein; Provisional; Region: acpP; PRK00982
99598013733	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
99598013734	Cysteine-rich domain; Region: CCG; pfam02754
99598013735	Cysteine-rich domain; Region: CCG; pfam02754
99598013736	CHAT domain; Region: CHAT; pfam12770
99598013737	AAA ATPase domain; Region: AAA_16; pfam13191
99598013738	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013739	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013740	TPR motif; other site
99598013741	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013742	binding surface
99598013743	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013744	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013745	Tetratricopeptide repeat; Region: TPR_10; pfam13374
99598013746	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013747	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013748	binding surface
99598013749	TPR motif; other site
99598013750	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013751	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013752	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013753	binding surface
99598013754	TPR motif; other site
99598013755	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013756	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013757	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013758	binding surface
99598013759	TPR motif; other site
99598013760	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013761	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013762	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598013763	oligomeric interface; other site
99598013764	putative active site [active]
99598013765	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
99598013766	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
99598013767	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
99598013768	trimer interface [polypeptide binding]; other site
99598013769	active site
99598013770	UDP-GlcNAc binding site [chemical binding]; other site
99598013771	lipid binding site [chemical binding]; lipid-binding site
99598013772	agmatinase; Region: agmatinase; TIGR01230
99598013773	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
99598013774	putative active site [active]
99598013775	Mn binding site [ion binding]; other site
99598013776	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
99598013777	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99598013778	metal binding site [ion binding]; metal-binding site
99598013779	active site
99598013780	I-site; other site
99598013781	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99598013782	Leucine rich repeat; Region: LRR_8; pfam13855
99598013783	Leucine rich repeat; Region: LRR_8; pfam13855
99598013784	Leucine rich repeat; Region: LRR_8; pfam13855
99598013785	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
99598013786	threonine dehydratase; Reviewed; Region: PRK09224
99598013787	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
99598013788	tetramer interface [polypeptide binding]; other site
99598013789	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598013790	catalytic residue [active]
99598013791	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
99598013792	putative Ile/Val binding site [chemical binding]; other site
99598013793	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
99598013794	putative Ile/Val binding site [chemical binding]; other site
99598013795	Helix-turn-helix domain; Region: HTH_18; pfam12833
99598013796	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
99598013797	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
99598013798	DNA binding site [nucleotide binding]
99598013799	active site
99598013800	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
99598013801	putative heme binding pocket [chemical binding]; other site
99598013802	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
99598013803	hypothetical protein; Provisional; Region: PRK07236
99598013804	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99598013805	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598013806	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
99598013807	Walker A/P-loop; other site
99598013808	ATP binding site [chemical binding]; other site
99598013809	Q-loop/lid; other site
99598013810	ABC transporter signature motif; other site
99598013811	Walker B; other site
99598013812	D-loop; other site
99598013813	H-loop/switch region; other site
99598013814	Uncharacterized conserved protein [Function unknown]; Region: COG5464
99598013815	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
99598013816	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
99598013817	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99598013818	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99598013819	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598013820	Walker A/P-loop; other site
99598013821	ATP binding site [chemical binding]; other site
99598013822	Q-loop/lid; other site
99598013823	ABC transporter signature motif; other site
99598013824	Walker B; other site
99598013825	D-loop; other site
99598013826	H-loop/switch region; other site
99598013827	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
99598013828	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
99598013829	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
99598013830	glycogen binding site [chemical binding]; other site
99598013831	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
99598013832	active site
99598013833	catalytic site [active]
99598013834	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
99598013835	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
99598013836	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
99598013837	cyanophycin synthetase; Provisional; Region: PRK14016
99598013838	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
99598013839	NurA nuclease; Region: NurA; smart00933
99598013840	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
99598013841	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
99598013842	PAS domain S-box; Region: sensory_box; TIGR00229
99598013843	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598013844	putative active site [active]
99598013845	heme pocket [chemical binding]; other site
99598013846	GAF domain; Region: GAF; cl17456
99598013847	GAF domain; Region: GAF_2; pfam13185
99598013848	PAS domain S-box; Region: sensory_box; TIGR00229
99598013849	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598013850	putative active site [active]
99598013851	heme pocket [chemical binding]; other site
99598013852	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
99598013853	cyclase homology domain; Region: CHD; cd07302
99598013854	nucleotidyl binding site; other site
99598013855	metal binding site [ion binding]; metal-binding site
99598013856	dimer interface [polypeptide binding]; other site
99598013857	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
99598013858	deoxyhypusine synthase-like protein; Provisional; Region: PRK00770
99598013859	deoxyhypusine synthase; Region: dhys; TIGR00321
99598013860	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
99598013861	putative ADP-ribose binding site [chemical binding]; other site
99598013862	putative active site [active]
99598013863	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
99598013864	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
99598013865	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
99598013866	homodimer interface [polypeptide binding]; other site
99598013867	Walker A motif; other site
99598013868	ATP binding site [chemical binding]; other site
99598013869	hydroxycobalamin binding site [chemical binding]; other site
99598013870	Walker B motif; other site
99598013871	PRC-barrel domain; Region: PRC; pfam05239
99598013872	PRC-barrel domain; Region: PRC; pfam05239
99598013873	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
99598013874	Walker A/P-loop; other site
99598013875	ATP binding site [chemical binding]; other site
99598013876	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
99598013877	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
99598013878	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
99598013879	ABC transporter signature motif; other site
99598013880	Walker B; other site
99598013881	D-loop; other site
99598013882	H-loop/switch region; other site
99598013883	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598013884	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598013885	active site
99598013886	ATP binding site [chemical binding]; other site
99598013887	substrate binding site [chemical binding]; other site
99598013888	activation loop (A-loop); other site
99598013889	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013890	binding surface
99598013891	TPR motif; other site
99598013892	TPR repeat; Region: TPR_11; pfam13414
99598013893	TPR repeat; Region: TPR_11; pfam13414
99598013894	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013895	binding surface
99598013896	TPR motif; other site
99598013897	TPR repeat; Region: TPR_11; pfam13414
99598013898	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013899	binding surface
99598013900	TPR motif; other site
99598013901	TPR repeat; Region: TPR_11; pfam13414
99598013902	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013903	binding surface
99598013904	TPR motif; other site
99598013905	TPR repeat; Region: TPR_11; pfam13414
99598013906	aspartate kinase; Reviewed; Region: PRK06635
99598013907	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
99598013908	putative catalytic residues [active]
99598013909	putative nucleotide binding site [chemical binding]; other site
99598013910	putative aspartate binding site [chemical binding]; other site
99598013911	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
99598013912	putative allosteric regulatory site; other site
99598013913	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
99598013914	putative allosteric regulatory residue; other site
99598013915	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
99598013916	putative allosteric regulatory site; other site
99598013917	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
99598013918	putative allosteric regulatory residue; other site
99598013919	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
99598013920	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
99598013921	phosphopeptide binding site; other site
99598013922	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598013923	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598013924	dimerization interface [polypeptide binding]; other site
99598013925	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598013926	ATP binding site [chemical binding]; other site
99598013927	Mg2+ binding site [ion binding]; other site
99598013928	G-X-G motif; other site
99598013929	Archaeal flavoproteins [Energy production and conversion]; Region: COG1036
99598013930	Protein kinase domain; Region: Pkinase; pfam00069
99598013931	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598013932	active site
99598013933	ATP binding site [chemical binding]; other site
99598013934	substrate binding site [chemical binding]; other site
99598013935	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
99598013936	substrate binding site [chemical binding]; other site
99598013937	activation loop (A-loop); other site
99598013938	activation loop (A-loop); other site
99598013939	AAA ATPase domain; Region: AAA_16; pfam13191
99598013940	Predicted ATPase [General function prediction only]; Region: COG3899
99598013941	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598013942	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598013943	GAF domain; Region: GAF; pfam01590
99598013944	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598013945	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598013946	ATP binding site [chemical binding]; other site
99598013947	Mg2+ binding site [ion binding]; other site
99598013948	G-X-G motif; other site
99598013949	Response regulator receiver domain; Region: Response_reg; pfam00072
99598013950	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598013951	active site
99598013952	phosphorylation site [posttranslational modification]
99598013953	intermolecular recognition site; other site
99598013954	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598013955	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598013956	dimer interface [polypeptide binding]; other site
99598013957	phosphorylation site [posttranslational modification]
99598013958	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598013959	ATP binding site [chemical binding]; other site
99598013960	Mg2+ binding site [ion binding]; other site
99598013961	G-X-G motif; other site
99598013962	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
99598013963	nudix motif; other site
99598013964	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598013965	putative active site [active]
99598013966	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
99598013967	active site
99598013968	dimer interface [polypeptide binding]; other site
99598013969	metal binding site [ion binding]; metal-binding site
99598013970	Circadian oscillating protein COP23; Region: COP23; pfam14218
99598013971	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
99598013972	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
99598013973	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
99598013974	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013975	TPR motif; other site
99598013976	TPR repeat; Region: TPR_11; pfam13414
99598013977	binding surface
99598013978	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013979	TPR motif; other site
99598013980	binding surface
99598013981	TPR repeat; Region: TPR_11; pfam13414
99598013982	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
99598013983	protein binding site [polypeptide binding]; other site
99598013984	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
99598013985	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013986	binding surface
99598013987	TPR motif; other site
99598013988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013989	binding surface
99598013990	TPR motif; other site
99598013991	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598013992	binding surface
99598013993	TPR motif; other site
99598013994	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598013995	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598013996	active site
99598013997	ATP binding site [chemical binding]; other site
99598013998	substrate binding site [chemical binding]; other site
99598013999	activation loop (A-loop); other site
99598014000	biotin synthase; Region: bioB; TIGR00433
99598014001	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598014002	FeS/SAM binding site; other site
99598014003	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
99598014004	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
99598014005	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
99598014006	hypothetical protein; Validated; Region: PRK00029
99598014007	Uncharacterized conserved protein [Function unknown]; Region: COG0397
99598014008	Predicted kinase [General function prediction only]; Region: COG4240
99598014009	active site
99598014010	Protein of unknown function (DUF565); Region: DUF565; pfam04483
99598014011	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
99598014012	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
99598014013	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
99598014014	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
99598014015	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
99598014016	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598014017	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598014018	dimer interface [polypeptide binding]; other site
99598014019	phosphorylation site [posttranslational modification]
99598014020	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598014021	ATP binding site [chemical binding]; other site
99598014022	Mg2+ binding site [ion binding]; other site
99598014023	G-X-G motif; other site
99598014024	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598014025	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598014026	active site
99598014027	phosphorylation site [posttranslational modification]
99598014028	intermolecular recognition site; other site
99598014029	dimerization interface [polypeptide binding]; other site
99598014030	KaiA domain; Region: KaiA; pfam07688
99598014031	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
99598014032	tetramer interface [polypeptide binding]; other site
99598014033	dimer interface [polypeptide binding]; other site
99598014034	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
99598014035	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
99598014036	Walker A motif; other site
99598014037	ATP binding site [chemical binding]; other site
99598014038	Walker B motif; other site
99598014039	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
99598014040	ATP binding site [chemical binding]; other site
99598014041	Walker B motif; other site
99598014042	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
99598014043	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
99598014044	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99598014045	RNA binding surface [nucleotide binding]; other site
99598014046	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
99598014047	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99598014048	NAD(P) binding site [chemical binding]; other site
99598014049	active site
99598014050	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
99598014051	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
99598014052	putative active site; other site
99598014053	catalytic residue [active]
99598014054	Protein of unknown function (DUF433); Region: DUF433; cl01030
99598014055	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
99598014056	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598014057	dimer interface [polypeptide binding]; other site
99598014058	conserved gate region; other site
99598014059	putative PBP binding loops; other site
99598014060	ABC-ATPase subunit interface; other site
99598014061	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598014062	Walker A/P-loop; other site
99598014063	ATP binding site [chemical binding]; other site
99598014064	ABC transporter; Region: ABC_tran; pfam00005
99598014065	Q-loop/lid; other site
99598014066	ABC transporter signature motif; other site
99598014067	Walker B; other site
99598014068	D-loop; other site
99598014069	H-loop/switch region; other site
99598014070	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
99598014071	Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279
99598014072	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
99598014073	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
99598014074	catalytic motif [active]
99598014075	Zn binding site [ion binding]; other site
99598014076	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598014077	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598014078	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598014079	Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346
99598014080	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
99598014081	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
99598014082	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
99598014083	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
99598014084	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
99598014085	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
99598014086	tandem repeat interface [polypeptide binding]; other site
99598014087	oligomer interface [polypeptide binding]; other site
99598014088	active site residues [active]
99598014089	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
99598014090	tandem repeat interface [polypeptide binding]; other site
99598014091	oligomer interface [polypeptide binding]; other site
99598014092	active site residues [active]
99598014093	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
99598014094	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
99598014095	homotetramer interface [polypeptide binding]; other site
99598014096	FMN binding site [chemical binding]; other site
99598014097	homodimer contacts [polypeptide binding]; other site
99598014098	putative active site [active]
99598014099	putative substrate binding site [chemical binding]; other site
99598014100	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99598014101	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99598014102	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
99598014103	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
99598014104	Fatty acid desaturase; Region: FA_desaturase; pfam00487
99598014105	Di-iron ligands [ion binding]; other site
99598014106	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598014107	oligomeric interface; other site
99598014108	putative active site [active]
99598014109	homodimer interface [polypeptide binding]; other site
99598014110	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
99598014111	catalytic site [active]
99598014112	putative active site [active]
99598014113	putative substrate binding site [chemical binding]; other site
99598014114	TPR repeat; Region: TPR_11; pfam13414
99598014115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598014116	binding surface
99598014117	TPR motif; other site
99598014118	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598014119	binding surface
99598014120	TPR motif; other site
99598014121	TPR repeat; Region: TPR_11; pfam13414
99598014122	TPR repeat; Region: TPR_11; pfam13414
99598014123	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598014124	binding surface
99598014125	TPR motif; other site
99598014126	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598014127	PIN domain; Region: PIN_3; pfam13470
99598014128	DNA binding domain, excisionase family; Region: excise; TIGR01764
99598014129	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99598014130	active site
99598014131	Protein of unknown function (DUF1688); Region: DUF1688; pfam07958
99598014132	hypothetical protein; Validated; Region: PRK07198
99598014133	GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471
99598014134	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
99598014135	dimerization interface [polypeptide binding]; other site
99598014136	active site
99598014137	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598014138	binding surface
99598014139	TPR motif; other site
99598014140	TPR repeat; Region: TPR_11; pfam13414
99598014141	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
99598014142	FAD binding domain; Region: FAD_binding_4; pfam01565
99598014143	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
99598014144	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
99598014145	putative active site [active]
99598014146	adenylation catalytic residue [active]
99598014147	conserved hypothetical protein; Region: TIGR02231
99598014148	TIR domain; Region: TIR_2; pfam13676
99598014149	TIR domain; Region: TIR_2; pfam13676
99598014150	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
99598014151	catalytic triad [active]
99598014152	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
99598014153	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
99598014154	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
99598014155	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
99598014156	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
99598014157	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598014158	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598014159	active site
99598014160	ATP binding site [chemical binding]; other site
99598014161	substrate binding site [chemical binding]; other site
99598014162	activation loop (A-loop); other site
99598014163	Bacterial SH3 domain; Region: SH3_3; pfam08239
99598014164	Protein of unknown function (DUF433); Region: DUF433; pfam04255
99598014165	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
99598014166	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
99598014167	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
99598014168	Right handed beta helix region; Region: Beta_helix; pfam13229
99598014169	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
99598014170	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
99598014171	ligand binding site [chemical binding]; other site
99598014172	Domain of unknown function DUF11; Region: DUF11; pfam01345
99598014173	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
99598014174	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
99598014175	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
99598014176	P loop; other site
99598014177	Nucleotide binding site [chemical binding]; other site
99598014178	DTAP/Switch II; other site
99598014179	chlorophyll synthase, ChlG; Region: ChlG; TIGR02056
99598014180	UbiA prenyltransferase family; Region: UbiA; pfam01040
99598014181	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242
99598014182	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
99598014183	putative NAD(P) binding site [chemical binding]; other site
99598014184	catalytic Zn binding site [ion binding]; other site
99598014185	structural Zn binding site [ion binding]; other site
99598014186	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
99598014187	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
99598014188	active site
99598014189	PUCC protein; Region: PUCC; pfam03209
99598014190	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99598014191	putative substrate translocation pore; other site
99598014192	Predicted transcriptional regulator [Transcription]; Region: COG2944
99598014193	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598014194	non-specific DNA binding site [nucleotide binding]; other site
99598014195	salt bridge; other site
99598014196	sequence-specific DNA binding site [nucleotide binding]; other site
99598014197	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
99598014198	putative active site [active]
99598014199	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
99598014200	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
99598014201	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99598014202	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
99598014203	active site
99598014204	catalytic tetrad [active]
99598014205	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
99598014206	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
99598014207	ATP binding site [chemical binding]; other site
99598014208	Mg++ binding site [ion binding]; other site
99598014209	motif III; other site
99598014210	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598014211	nucleotide binding region [chemical binding]; other site
99598014212	ATP-binding site [chemical binding]; other site
99598014213	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
99598014214	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
99598014215	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598014216	FeS/SAM binding site; other site
99598014217	TRAM domain; Region: TRAM; cl01282
99598014218	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722
99598014219	phosphate binding site [ion binding]; other site
99598014220	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
99598014221	putative active site [active]
99598014222	substrate binding site [chemical binding]; other site
99598014223	redox center [active]
99598014224	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
99598014225	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
99598014226	CHASE2 domain; Region: CHASE2; pfam05226
99598014227	PAS fold; Region: PAS_4; pfam08448
99598014228	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598014229	putative active site [active]
99598014230	heme pocket [chemical binding]; other site
99598014231	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
99598014232	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99598014233	metal binding site [ion binding]; metal-binding site
99598014234	active site
99598014235	I-site; other site
99598014236	L-aspartate oxidase; Provisional; Region: PRK07395
99598014237	L-aspartate oxidase; Provisional; Region: PRK06175
99598014238	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
99598014239	Photosystem II 12 kDa extrinsic protein (PsbU); Region: PsbU; pfam06514
99598014240	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
99598014241	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
99598014242	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
99598014243	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
99598014244	Protein of unknown function (DUF512); Region: DUF512; pfam04459
99598014245	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
99598014246	FOG: CBS domain [General function prediction only]; Region: COG0517
99598014247	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
99598014248	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598014249	PAS domain; Region: PAS_9; pfam13426
99598014250	putative active site [active]
99598014251	heme pocket [chemical binding]; other site
99598014252	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598014253	GAF domain; Region: GAF; pfam01590
99598014254	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598014255	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598014256	putative active site [active]
99598014257	heme pocket [chemical binding]; other site
99598014258	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598014259	putative active site [active]
99598014260	heme pocket [chemical binding]; other site
99598014261	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
99598014262	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598014263	putative active site [active]
99598014264	heme pocket [chemical binding]; other site
99598014265	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598014266	dimer interface [polypeptide binding]; other site
99598014267	phosphorylation site [posttranslational modification]
99598014268	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598014269	ATP binding site [chemical binding]; other site
99598014270	Mg2+ binding site [ion binding]; other site
99598014271	G-X-G motif; other site
99598014272	Response regulator receiver domain; Region: Response_reg; pfam00072
99598014273	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598014274	active site
99598014275	phosphorylation site [posttranslational modification]
99598014276	intermolecular recognition site; other site
99598014277	dimerization interface [polypeptide binding]; other site
99598014278	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99598014279	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
99598014280	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
99598014281	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
99598014282	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598014283	putative active site [active]
99598014284	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598014285	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598014286	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
99598014287	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598014288	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
99598014289	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99598014290	NAD(P) binding site [chemical binding]; other site
99598014291	active site
99598014292	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598014293	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
99598014294	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
99598014295	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598014296	S-adenosylmethionine binding site [chemical binding]; other site
99598014297	S-adenosylmethionine binding site [chemical binding]; other site
99598014298	Methyltransferase domain; Region: Methyltransf_11; pfam08241
99598014299	Methyltransferase domain; Region: Methyltransf_23; pfam13489
99598014300	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
99598014301	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
99598014302	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
99598014303	Walker A/P-loop; other site
99598014304	ATP binding site [chemical binding]; other site
99598014305	Q-loop/lid; other site
99598014306	ABC transporter signature motif; other site
99598014307	Walker B; other site
99598014308	D-loop; other site
99598014309	H-loop/switch region; other site
99598014310	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
99598014311	putative carbohydrate binding site [chemical binding]; other site
99598014312	Methyltransferase domain; Region: Methyltransf_24; pfam13578
99598014313	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
99598014314	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
99598014315	trimer interface [polypeptide binding]; other site
99598014316	active site
99598014317	substrate binding site [chemical binding]; other site
99598014318	CoA binding site [chemical binding]; other site
99598014319	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
99598014320	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
99598014321	putative active site [active]
99598014322	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
99598014323	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
99598014324	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
99598014325	Ligand binding site; other site
99598014326	oligomer interface; other site
99598014327	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
99598014328	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
99598014329	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
99598014330	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598014331	active site
99598014332	motif I; other site
99598014333	motif II; other site
99598014334	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
99598014335	S-adenosylmethionine binding site [chemical binding]; other site
99598014336	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598014337	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
99598014338	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
99598014339	Probable Catalytic site; other site
99598014340	metal-binding site
99598014341	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
99598014342	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598014343	pyruvate kinase; Provisional; Region: PRK06354
99598014344	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
99598014345	domain interfaces; other site
99598014346	active site
99598014347	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
99598014348	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
99598014349	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
99598014350	putative di-iron ligands [ion binding]; other site
99598014351	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
99598014352	Transposase; Region: DEDD_Tnp_IS110; pfam01548
99598014353	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
99598014354	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
99598014355	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
99598014356	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598014357	active site
99598014358	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
99598014359	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
99598014360	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
99598014361	Transposase; Region: DEDD_Tnp_IS110; pfam01548
99598014362	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
99598014363	Core-2/I-Branching enzyme; Region: Branch; pfam02485
99598014364	Protein of unknown function (DUF563); Region: DUF563; pfam04577
99598014365	O-Antigen ligase; Region: Wzy_C; pfam04932
99598014366	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
99598014367	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598014368	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598014369	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
99598014370	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
99598014371	DXD motif; other site
99598014372	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598014373	putative acyl transferase; Provisional; Region: PRK10191
99598014374	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
99598014375	trimer interface [polypeptide binding]; other site
99598014376	active site
99598014377	substrate binding site [chemical binding]; other site
99598014378	CoA binding site [chemical binding]; other site
99598014379	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
99598014380	Chain length determinant protein; Region: Wzz; pfam02706
99598014381	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
99598014382	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
99598014383	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99598014384	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
99598014385	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
99598014386	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598014387	S-adenosylmethionine binding site [chemical binding]; other site
99598014388	Bacterial SH3 domain; Region: SH3_3; pfam08239
99598014389	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
99598014390	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
99598014391	active site
99598014392	metal binding site [ion binding]; metal-binding site
99598014393	CTP synthetase; Validated; Region: pyrG; PRK05380
99598014394	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
99598014395	Catalytic site [active]
99598014396	active site
99598014397	UTP binding site [chemical binding]; other site
99598014398	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
99598014399	active site
99598014400	putative oxyanion hole; other site
99598014401	catalytic triad [active]
99598014402	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
99598014403	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
99598014404	nucleotide binding site [chemical binding]; other site
99598014405	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
99598014406	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598014407	dimer interface [polypeptide binding]; other site
99598014408	conserved gate region; other site
99598014409	ABC-ATPase subunit interface; other site
99598014410	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
99598014411	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99598014412	TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949
99598014413	catalytic residues [active]
99598014414	Uncharacterized conserved protein [Function unknown]; Region: COG5464
99598014415	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
99598014416	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598014417	putative active site [active]
99598014418	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
99598014419	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598014420	TPR repeat; Region: TPR_11; pfam13414
99598014421	binding surface
99598014422	TPR motif; other site
99598014423	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
99598014424	XisH protein; Region: XisH; pfam08814
99598014425	XisI protein; Region: XisI; pfam08869
99598014426	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
99598014427	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598014428	active site
99598014429	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
99598014430	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598014431	pseudaminic acid synthase; Region: PseI; TIGR03586
99598014432	NeuB family; Region: NeuB; pfam03102
99598014433	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
99598014434	NeuB binding interface [polypeptide binding]; other site
99598014435	putative substrate binding site [chemical binding]; other site
99598014436	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
99598014437	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
99598014438	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
99598014439	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598014440	Methyltransferase domain; Region: Methyltransf_23; pfam13489
99598014441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598014442	S-adenosylmethionine binding site [chemical binding]; other site
99598014443	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
99598014444	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
99598014445	Ligand Binding Site [chemical binding]; other site
99598014446	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
99598014447	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
99598014448	glutamase interaction surface [polypeptide binding]; other site
99598014449	substrate binding site [chemical binding]; other site
99598014450	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
99598014451	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
99598014452	putative active site [active]
99598014453	oxyanion strand; other site
99598014454	catalytic triad [active]
99598014455	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
99598014456	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
99598014457	ligand binding site; other site
99598014458	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
99598014459	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
99598014460	inhibitor-cofactor binding pocket; inhibition site
99598014461	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598014462	catalytic residue [active]
99598014463	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
99598014464	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
99598014465	NAD(P) binding site [chemical binding]; other site
99598014466	homodimer interface [polypeptide binding]; other site
99598014467	substrate binding site [chemical binding]; other site
99598014468	active site
99598014469	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
99598014470	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
99598014471	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
99598014472	phosphopeptide binding site; other site
99598014473	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598014474	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598014475	active site
99598014476	ATP binding site [chemical binding]; other site
99598014477	substrate binding site [chemical binding]; other site
99598014478	activation loop (A-loop); other site
99598014479	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
99598014480	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
99598014481	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
99598014482	active site
99598014483	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598014484	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598014485	putative active site [active]
99598014486	heme pocket [chemical binding]; other site
99598014487	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598014488	putative active site [active]
99598014489	heme pocket [chemical binding]; other site
99598014490	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598014491	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598014492	dimer interface [polypeptide binding]; other site
99598014493	phosphorylation site [posttranslational modification]
99598014494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598014495	ATP binding site [chemical binding]; other site
99598014496	Mg2+ binding site [ion binding]; other site
99598014497	G-X-G motif; other site
99598014498	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
99598014499	pseudouridine synthase; Region: TIGR00093
99598014500	active site
99598014501	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
99598014502	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598014503	Putative restriction endonuclease; Region: Uma2; pfam05685
99598014504	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
99598014505	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
99598014506	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
99598014507	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99598014508	active site
99598014509	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
99598014510	Domain of unknown function DUF21; Region: DUF21; pfam01595
99598014511	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
99598014512	Transporter associated domain; Region: CorC_HlyC; smart01091
99598014513	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
99598014514	Ligand Binding Site [chemical binding]; other site
99598014515	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
99598014516	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
99598014517	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
99598014518	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
99598014519	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
99598014520	Mg binding site [ion binding]; other site
99598014521	nucleotide binding site [chemical binding]; other site
99598014522	putative protofilament interface [polypeptide binding]; other site
99598014523	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
99598014524	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598014525	putative active site [active]
99598014526	heme pocket [chemical binding]; other site
99598014527	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598014528	dimer interface [polypeptide binding]; other site
99598014529	phosphorylation site [posttranslational modification]
99598014530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598014531	ATP binding site [chemical binding]; other site
99598014532	Mg2+ binding site [ion binding]; other site
99598014533	G-X-G motif; other site
99598014534	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598014535	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598014536	active site
99598014537	phosphorylation site [posttranslational modification]
99598014538	intermolecular recognition site; other site
99598014539	dimerization interface [polypeptide binding]; other site
99598014540	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
99598014541	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
99598014542	active site
99598014543	substrate binding site [chemical binding]; other site
99598014544	metal binding site [ion binding]; metal-binding site
99598014545	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
99598014546	active site
99598014547	dimerization interface [polypeptide binding]; other site
99598014548	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
99598014549	Nitrogen regulatory protein P-II; Region: P-II; smart00938
99598014550	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
99598014551	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
99598014552	substrate binding site [chemical binding]; other site
99598014553	dimer interface [polypeptide binding]; other site
99598014554	ATP binding site [chemical binding]; other site
99598014555	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
99598014556	active site
99598014557	catalytic triad [active]
99598014558	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
99598014559	CHAT domain; Region: CHAT; pfam12770
99598014560	Caspase domain; Region: Peptidase_C14; pfam00656
99598014561	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598014562	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598014563	structural tetrad; other site
99598014564	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598014565	putative active site [active]
99598014566	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
99598014567	Dynamin family; Region: Dynamin_N; pfam00350
99598014568	G1 box; other site
99598014569	GTP/Mg2+ binding site [chemical binding]; other site
99598014570	G2 box; other site
99598014571	Switch I region; other site
99598014572	G3 box; other site
99598014573	Switch II region; other site
99598014574	G4 box; other site
99598014575	G5 box; other site
99598014576	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
99598014577	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
99598014578	Dynamin family; Region: Dynamin_N; pfam00350
99598014579	G1 box; other site
99598014580	GTP/Mg2+ binding site [chemical binding]; other site
99598014581	G2 box; other site
99598014582	Switch I region; other site
99598014583	G3 box; other site
99598014584	Switch II region; other site
99598014585	G4 box; other site
99598014586	G5 box; other site
99598014587	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
99598014588	Dynamin family; Region: Dynamin_N; pfam00350
99598014589	G1 box; other site
99598014590	GTP/Mg2+ binding site [chemical binding]; other site
99598014591	G2 box; other site
99598014592	Switch I region; other site
99598014593	G3 box; other site
99598014594	Switch II region; other site
99598014595	G4 box; other site
99598014596	G5 box; other site
99598014597	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
99598014598	Dynamin family; Region: Dynamin_N; pfam00350
99598014599	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
99598014600	G1 box; other site
99598014601	GTP/Mg2+ binding site [chemical binding]; other site
99598014602	Switch I region; other site
99598014603	G2 box; other site
99598014604	Switch II region; other site
99598014605	G3 box; other site
99598014606	G4 box; other site
99598014607	G5 box; other site
99598014608	Domain of unknown function (DUF697); Region: DUF697; pfam05128
99598014609	DDHD domain; Region: DDHD; pfam02862
99598014610	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
99598014611	Amidinotransferase; Region: Amidinotransf; cl12043
99598014612	Uncharacterized conserved protein [Function unknown]; Region: COG1915
99598014613	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
99598014614	homodimer interface [polypeptide binding]; other site
99598014615	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598014616	Coenzyme A binding pocket [chemical binding]; other site
99598014617	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598014618	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598014619	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
99598014620	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
99598014621	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
99598014622	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
99598014623	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99598014624	NAD(P) binding site [chemical binding]; other site
99598014625	active site
99598014626	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
99598014627	putative ADP-binding pocket [chemical binding]; other site
99598014628	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598014629	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
99598014630	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598014631	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
99598014632	putative metal binding site; other site
99598014633	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598014634	TPR motif; other site
99598014635	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598014636	binding surface
99598014637	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598014638	binding surface
99598014639	TPR repeat; Region: TPR_11; pfam13414
99598014640	TPR motif; other site
99598014641	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598014642	aspartate aminotransferase; Provisional; Region: PRK05764
99598014643	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99598014644	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598014645	homodimer interface [polypeptide binding]; other site
99598014646	catalytic residue [active]
99598014647	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
99598014648	glutaminase A; Region: Gln_ase; TIGR03814
99598014649	Uncharacterized conserved protein [Function unknown]; Region: COG1801
99598014650	Putative restriction endonuclease; Region: Uma2; pfam05685
99598014651	Uncharacterized conserved protein [Function unknown]; Region: COG3349
99598014652	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99598014653	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598014654	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598014655	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598014656	ligand binding site [chemical binding]; other site
99598014657	flexible hinge region; other site
99598014658	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
99598014659	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
99598014660	Peptidase family M23; Region: Peptidase_M23; pfam01551
99598014661	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
99598014662	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
99598014663	CHAT domain; Region: CHAT; pfam12770
99598014664	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598014665	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598014666	binding surface
99598014667	TPR motif; other site
99598014668	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598014669	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598014670	binding surface
99598014671	TPR motif; other site
99598014672	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598014673	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598014674	recombination protein RecR; Region: recR; TIGR00615
99598014675	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
99598014676	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
99598014677	YCII-related domain; Region: YCII; cl00999
99598014678	Uncharacterized conserved protein [Function unknown]; Region: COG3937
99598014679	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
99598014680	c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177
99598014681	ResB-like family; Region: ResB; pfam05140
99598014682	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
99598014683	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
99598014684	PemK-like protein; Region: PemK; pfam02452
99598014685	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
99598014686	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
99598014687	dimer interface [polypeptide binding]; other site
99598014688	PYR/PP interface [polypeptide binding]; other site
99598014689	TPP binding site [chemical binding]; other site
99598014690	substrate binding site [chemical binding]; other site
99598014691	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
99598014692	Domain of unknown function; Region: EKR; pfam10371
99598014693	4Fe-4S binding domain; Region: Fer4_6; pfam12837
99598014694	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
99598014695	TPP-binding site [chemical binding]; other site
99598014696	dimer interface [polypeptide binding]; other site
99598014697	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
99598014698	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
99598014699	homodimer interface [polypeptide binding]; other site
99598014700	active site
99598014701	TDP-binding site; other site
99598014702	acceptor substrate-binding pocket; other site
99598014703	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
99598014704	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
99598014705	putative rRNA binding site [nucleotide binding]; other site
99598014706	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
99598014707	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
99598014708	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598014709	catalytic residue [active]
99598014710	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
99598014711	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
99598014712	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
99598014713	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
99598014714	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
99598014715	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
99598014716	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
99598014717	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
99598014718	catalytic site [active]
99598014719	putative active site [active]
99598014720	putative substrate binding site [chemical binding]; other site
99598014721	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
99598014722	active site residue [active]
99598014723	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99598014724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598014725	active site
99598014726	phosphorylation site [posttranslational modification]
99598014727	intermolecular recognition site; other site
99598014728	dimerization interface [polypeptide binding]; other site
99598014729	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99598014730	DNA binding site [nucleotide binding]
99598014731	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
99598014732	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
99598014733	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
99598014734	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
99598014735	cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876
99598014736	Ycf39; Provisional; Region: ycf39; CHL00194
99598014737	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
99598014738	NAD(P) binding site [chemical binding]; other site
99598014739	putative active site [active]
99598014740	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
99598014741	ATP-NAD kinase; Region: NAD_kinase; pfam01513
99598014742	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99598014743	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598014744	active site
99598014745	phosphorylation site [posttranslational modification]
99598014746	intermolecular recognition site; other site
99598014747	dimerization interface [polypeptide binding]; other site
99598014748	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99598014749	DNA binding site [nucleotide binding]
99598014750	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
99598014751	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
99598014752	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
99598014753	homodimer interface [polypeptide binding]; other site
99598014754	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598014755	catalytic residue [active]
99598014756	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
99598014757	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
99598014758	Walker A/P-loop; other site
99598014759	ATP binding site [chemical binding]; other site
99598014760	Q-loop/lid; other site
99598014761	ABC transporter signature motif; other site
99598014762	Walker B; other site
99598014763	D-loop; other site
99598014764	H-loop/switch region; other site
99598014765	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598014766	dimer interface [polypeptide binding]; other site
99598014767	ABC-ATPase subunit interface; other site
99598014768	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
99598014769	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
99598014770	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
99598014771	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
99598014772	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
99598014773	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
99598014774	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
99598014775	active site
99598014776	ribulose/triose binding site [chemical binding]; other site
99598014777	phosphate binding site [ion binding]; other site
99598014778	substrate (anthranilate) binding pocket [chemical binding]; other site
99598014779	product (indole) binding pocket [chemical binding]; other site
99598014780	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
99598014781	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99598014782	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
99598014783	Uncharacterized conserved protein [Function unknown]; Region: COG4715
99598014784	Cut8; Region: Cut8; pfam08559
99598014785	sucrose synthase; Region: sucr_synth; TIGR02470
99598014786	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
99598014787	putative ADP-binding pocket [chemical binding]; other site
99598014788	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598014789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598014790	active site
99598014791	phosphorylation site [posttranslational modification]
99598014792	intermolecular recognition site; other site
99598014793	dimerization interface [polypeptide binding]; other site
99598014794	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
99598014795	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99598014796	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99598014797	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598014798	PAS fold; Region: PAS_3; pfam08447
99598014799	putative active site [active]
99598014800	heme pocket [chemical binding]; other site
99598014801	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598014802	GAF domain; Region: GAF; pfam01590
99598014803	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598014804	PAS fold; Region: PAS_3; pfam08447
99598014805	putative active site [active]
99598014806	heme pocket [chemical binding]; other site
99598014807	PAS domain S-box; Region: sensory_box; TIGR00229
99598014808	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598014809	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598014810	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
99598014811	Histidine kinase; Region: HisKA_2; pfam07568
99598014812	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598014813	ATP binding site [chemical binding]; other site
99598014814	Mg2+ binding site [ion binding]; other site
99598014815	G-X-G motif; other site
99598014816	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598014817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598014818	active site
99598014819	phosphorylation site [posttranslational modification]
99598014820	intermolecular recognition site; other site
99598014821	dimerization interface [polypeptide binding]; other site
99598014822	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598014823	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598014824	dimer interface [polypeptide binding]; other site
99598014825	phosphorylation site [posttranslational modification]
99598014826	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598014827	ATP binding site [chemical binding]; other site
99598014828	Mg2+ binding site [ion binding]; other site
99598014829	G-X-G motif; other site
99598014830	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
99598014831	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
99598014832	putative ligand binding site [chemical binding]; other site
99598014833	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
99598014834	Predicted flavoprotein [General function prediction only]; Region: COG0431
99598014835	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
99598014836	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598014837	putative active site [active]
99598014838	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598014839	putative active site [active]
99598014840	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
99598014841	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
99598014842	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
99598014843	active site
99598014844	catalytic site [active]
99598014845	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
99598014846	calcium/proton exchanger (cax); Region: cax; TIGR00378
99598014847	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
99598014848	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
99598014849	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598014850	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99598014851	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
99598014852	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
99598014853	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
99598014854	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
99598014855	N- and C-terminal domain interface [polypeptide binding]; other site
99598014856	active site
99598014857	MgATP binding site [chemical binding]; other site
99598014858	catalytic site [active]
99598014859	metal binding site [ion binding]; metal-binding site
99598014860	glycerol binding site [chemical binding]; other site
99598014861	homotetramer interface [polypeptide binding]; other site
99598014862	homodimer interface [polypeptide binding]; other site
99598014863	FBP binding site [chemical binding]; other site
99598014864	protein IIAGlc interface [polypeptide binding]; other site
99598014865	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
99598014866	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
99598014867	Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541
99598014868	Protein of unknown function (DUF423); Region: DUF423; pfam04241
99598014869	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
99598014870	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598014871	S-adenosylmethionine binding site [chemical binding]; other site
99598014872	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
99598014873	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
99598014874	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
99598014875	dimer interface [polypeptide binding]; other site
99598014876	putative metal binding site [ion binding]; other site
99598014877	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
99598014878	Resolvase, N terminal domain; Region: Resolvase; smart00857
99598014879	catalytic residues [active]
99598014880	Recombinase; Region: Recombinase; pfam07508
99598014881	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
99598014882	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99598014883	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
99598014884	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99598014885	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
99598014886	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
99598014887	tetramer interface [polypeptide binding]; other site
99598014888	heme binding pocket [chemical binding]; other site
99598014889	NADPH binding site [chemical binding]; other site
99598014890	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
99598014891	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
99598014892	cofactor binding site; other site
99598014893	DNA binding site [nucleotide binding]
99598014894	substrate interaction site [chemical binding]; other site
99598014895	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
99598014896	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
99598014897	putative acyl-acceptor binding pocket; other site
99598014898	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
99598014899	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
99598014900	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
99598014901	Response regulator receiver domain; Region: Response_reg; pfam00072
99598014902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598014903	active site
99598014904	phosphorylation site [posttranslational modification]
99598014905	intermolecular recognition site; other site
99598014906	dimerization interface [polypeptide binding]; other site
99598014907	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598014908	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
99598014909	dimer interface [polypeptide binding]; other site
99598014910	phosphorylation site [posttranslational modification]
99598014911	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598014912	ATP binding site [chemical binding]; other site
99598014913	Mg2+ binding site [ion binding]; other site
99598014914	G-X-G motif; other site
99598014915	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
99598014916	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
99598014917	acyl-activating enzyme (AAE) consensus motif; other site
99598014918	AMP binding site [chemical binding]; other site
99598014919	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
99598014920	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
99598014921	thioester reductase domain; Region: Thioester-redct; TIGR01746
99598014922	putative NAD(P) binding site [chemical binding]; other site
99598014923	active site
99598014924	putative substrate binding site [chemical binding]; other site
99598014925	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598014926	dimerization interface [polypeptide binding]; other site
99598014927	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598014928	dimer interface [polypeptide binding]; other site
99598014929	phosphorylation site [posttranslational modification]
99598014930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598014931	ATP binding site [chemical binding]; other site
99598014932	Mg2+ binding site [ion binding]; other site
99598014933	G-X-G motif; other site
99598014934	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598014935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598014936	active site
99598014937	phosphorylation site [posttranslational modification]
99598014938	intermolecular recognition site; other site
99598014939	dimerization interface [polypeptide binding]; other site
99598014940	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
99598014941	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
99598014942	TM-ABC transporter signature motif; other site
99598014943	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
99598014944	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
99598014945	TM-ABC transporter signature motif; other site
99598014946	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598014947	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
99598014948	putative ADP-binding pocket [chemical binding]; other site
99598014949	translation initiation factor IF-3; Region: infC; TIGR00168
99598014950	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
99598014951	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
99598014952	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
99598014953	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
99598014954	Phycobilisome protein; Region: Phycobilisome; cl08227
99598014955	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598014956	nitrogenase reductase; Reviewed; Region: PRK13236
99598014957	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
99598014958	Nucleotide-binding sites [chemical binding]; other site
99598014959	Walker A motif; other site
99598014960	Switch I region of nucleotide binding site; other site
99598014961	Fe4S4 binding sites [ion binding]; other site
99598014962	Switch II region of nucleotide binding site; other site
99598014963	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598014964	binding surface
99598014965	TPR repeat; Region: TPR_11; pfam13414
99598014966	TPR motif; other site
99598014967	TPR repeat; Region: TPR_11; pfam13414
99598014968	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
99598014969	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99598014970	active site
99598014971	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
99598014972	Predicted transcriptional regulator [Transcription]; Region: COG1959
99598014973	Transcriptional regulator; Region: Rrf2; cl17282
99598014974	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
99598014975	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
99598014976	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
99598014977	Cl- selectivity filter; other site
99598014978	Cl- binding residues [ion binding]; other site
99598014979	pore gating glutamate residue; other site
99598014980	dimer interface [polypeptide binding]; other site
99598014981	FOG: CBS domain [General function prediction only]; Region: COG0517
99598014982	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593
99598014983	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
99598014984	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
99598014985	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
99598014986	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
99598014987	[2Fe-2S] cluster binding site [ion binding]; other site
99598014988	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
99598014989	DNA binding residues [nucleotide binding]
99598014990	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
99598014991	dimer interface [polypeptide binding]; other site
99598014992	metal binding site [ion binding]; metal-binding site
99598014993	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
99598014994	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
99598014995	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99598014996	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
99598014997	Uncharacterized conserved protein [Function unknown]; Region: COG4925
99598014998	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
99598014999	short chain dehydrogenase; Provisional; Region: PRK06172
99598015000	classical (c) SDRs; Region: SDR_c; cd05233
99598015001	NAD(P) binding site [chemical binding]; other site
99598015002	active site
99598015003	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
99598015004	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
99598015005	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
99598015006	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
99598015007	putative NAD(P) binding site [chemical binding]; other site
99598015008	putative substrate binding site [chemical binding]; other site
99598015009	catalytic Zn binding site [ion binding]; other site
99598015010	structural Zn binding site [ion binding]; other site
99598015011	dimer interface [polypeptide binding]; other site
99598015012	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99598015013	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
99598015014	active site
99598015015	catalytic tetrad [active]
99598015016	Plastocyanin domain containing protein [General function prediction only]; Region: COG4633
99598015017	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
99598015018	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
99598015019	metal-binding site [ion binding]
99598015020	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99598015021	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598015022	motif II; other site
99598015023	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
99598015024	metal-binding site [ion binding]
99598015025	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
99598015026	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
99598015027	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
99598015028	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
99598015029	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
99598015030	putative NAD(P) binding site [chemical binding]; other site
99598015031	active site
99598015032	putative substrate binding site [chemical binding]; other site
99598015033	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
99598015034	FMN binding site [chemical binding]; other site
99598015035	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
99598015036	substrate binding site [chemical binding]; other site
99598015037	putative catalytic residue [active]
99598015038	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
99598015039	active site
99598015040	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
99598015041	Acyl transferase domain; Region: Acyl_transf_1; cl08282
99598015042	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
99598015043	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
99598015044	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
99598015045	active site
99598015046	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
99598015047	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
99598015048	putative NADP binding site [chemical binding]; other site
99598015049	active site
99598015050	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
99598015051	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
99598015052	active site
99598015053	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
99598015054	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
99598015055	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99598015056	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
99598015057	ParB-like nuclease domain; Region: ParB; smart00470
99598015058	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
99598015059	DNA methylase; Region: N6_N4_Mtase; cl17433
99598015060	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
99598015061	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
99598015062	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598015063	DevC protein; Region: devC; TIGR01185
99598015064	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
99598015065	FtsX-like permease family; Region: FtsX; pfam02687
99598015066	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
99598015067	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99598015068	NAD(P) binding site [chemical binding]; other site
99598015069	active site
99598015070	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704
99598015071	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
99598015072	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
99598015073	DXD motif; other site
99598015074	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598015075	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
99598015076	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
99598015077	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
99598015078	[2Fe-2S] cluster binding site [ion binding]; other site
99598015079	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
99598015080	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
99598015081	Protein of unknown function (DUF1625); Region: DUF1625; pfam07787
99598015082	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598015083	non-specific DNA binding site [nucleotide binding]; other site
99598015084	salt bridge; other site
99598015085	sequence-specific DNA binding site [nucleotide binding]; other site
99598015086	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
99598015087	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
99598015088	Peptidase family M50; Region: Peptidase_M50; pfam02163
99598015089	active site
99598015090	putative substrate binding region [chemical binding]; other site
99598015091	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
99598015092	FOG: CBS domain [General function prediction only]; Region: COG0517
99598015093	intracellular protease, PfpI family; Region: PfpI; TIGR01382
99598015094	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
99598015095	proposed catalytic triad [active]
99598015096	conserved cys residue [active]
99598015097	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
99598015098	dinuclear metal binding motif [ion binding]; other site
99598015099	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
99598015100	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
99598015101	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
99598015102	GIY-YIG motif/motif A; other site
99598015103	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598015104	dimer interface [polypeptide binding]; other site
99598015105	conserved gate region; other site
99598015106	putative PBP binding loops; other site
99598015107	ABC-ATPase subunit interface; other site
99598015108	Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425
99598015109	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
99598015110	active site
99598015111	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
99598015112	homodecamer interface [polypeptide binding]; other site
99598015113	GTP cyclohydrolase I; Provisional; Region: PLN03044
99598015114	active site
99598015115	putative catalytic site residues [active]
99598015116	zinc binding site [ion binding]; other site
99598015117	GTP-CH-I/GFRP interaction surface; other site
99598015118	short chain dehydrogenase; Provisional; Region: PRK07454
99598015119	classical (c) SDRs; Region: SDR_c; cd05233
99598015120	NAD(P) binding site [chemical binding]; other site
99598015121	active site
99598015122	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
99598015123	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
99598015124	acyl-ACP reductase; Provisional; Region: PRK14982
99598015125	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
99598015126	NAD(P) binding pocket [chemical binding]; other site
99598015127	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
99598015128	dinuclear metal binding motif [ion binding]; other site
99598015129	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
99598015130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598015131	dimer interface [polypeptide binding]; other site
99598015132	conserved gate region; other site
99598015133	putative PBP binding loops; other site
99598015134	ABC-ATPase subunit interface; other site
99598015135	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598015136	putative active site [active]
99598015137	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598015138	putative active site [active]
99598015139	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
99598015140	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598015141	FeS/SAM binding site; other site
99598015142	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
99598015143	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
99598015144	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
99598015145	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99598015146	RNA binding surface [nucleotide binding]; other site
99598015147	heterocyst differentiation control protein; Reviewed; Region: hetR; PRK13245
99598015148	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598015149	binding surface
99598015150	TPR repeat; Region: TPR_11; pfam13414
99598015151	TPR motif; other site
99598015152	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
99598015153	EamA-like transporter family; Region: EamA; pfam00892
99598015154	EamA-like transporter family; Region: EamA; pfam00892
99598015155	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
99598015156	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
99598015157	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
99598015158	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
99598015159	putative NAD(P) binding site [chemical binding]; other site
99598015160	catalytic Zn binding site [ion binding]; other site
99598015161	DNA binding domain, excisionase family; Region: excise; TIGR01764
99598015162	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
99598015163	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
99598015164	dinuclear metal binding motif [ion binding]; other site
99598015165	glutamine synthetase, type I; Region: GlnA; TIGR00653
99598015166	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
99598015167	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
99598015168	allophycocyanin, beta subunit; Region: apcB; TIGR01337
99598015169	XisH protein; Region: XisH; pfam08814
99598015170	XisI protein; Region: XisI; pfam08869
99598015171	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
99598015172	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99598015173	RNA binding surface [nucleotide binding]; other site
99598015174	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
99598015175	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598015176	CP12 domain; Region: CP12; pfam02672
99598015177	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99598015178	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99598015179	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
99598015180	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99598015181	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598015182	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
99598015183	Protein export membrane protein; Region: SecD_SecF; cl14618
99598015184	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
99598015185	Transposase; Region: DEDD_Tnp_IS110; pfam01548
99598015186	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
99598015187	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
99598015188	Cadmium resistance transporter; Region: Cad; pfam03596
99598015189	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
99598015190	iron-sulfur cluster [ion binding]; other site
99598015191	[2Fe-2S] cluster binding site [ion binding]; other site
99598015192	Pheophorbide a oxygenase; Region: PaO; pfam08417
99598015193	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
99598015194	MoaE interaction surface [polypeptide binding]; other site
99598015195	MoeB interaction surface [polypeptide binding]; other site
99598015196	thiocarboxylated glycine; other site
99598015197	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
99598015198	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
99598015199	Walker A/P-loop; other site
99598015200	ATP binding site [chemical binding]; other site
99598015201	Q-loop/lid; other site
99598015202	ABC transporter signature motif; other site
99598015203	Walker B; other site
99598015204	D-loop; other site
99598015205	H-loop/switch region; other site
99598015206	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
99598015207	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
99598015208	ABC-ATPase subunit  interface; other site
99598015209	dimer interface [polypeptide binding]; other site
99598015210	putative PBP binding regions; other site
99598015211	S-layer homology domain; Region: SLH; pfam00395
99598015212	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
99598015213	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
99598015214	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
99598015215	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
99598015216	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
99598015217	Predicted membrane protein [Function unknown]; Region: COG3431
99598015218	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
99598015219	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
99598015220	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
99598015221	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
99598015222	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
99598015223	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
99598015224	Walker A/P-loop; other site
99598015225	ATP binding site [chemical binding]; other site
99598015226	Q-loop/lid; other site
99598015227	ABC transporter signature motif; other site
99598015228	Walker B; other site
99598015229	D-loop; other site
99598015230	H-loop/switch region; other site
99598015231	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
99598015232	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
99598015233	FtsX-like permease family; Region: FtsX; pfam02687
99598015234	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
99598015235	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
99598015236	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598015237	SnoaL-like domain; Region: SnoaL_2; pfam12680
99598015238	short chain dehydrogenase; Provisional; Region: PRK06500
99598015239	classical (c) SDRs; Region: SDR_c; cd05233
99598015240	NAD(P) binding site [chemical binding]; other site
99598015241	active site
99598015242	Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897
99598015243	Cupin domain; Region: Cupin_2; pfam07883
99598015244	SnoaL-like domain; Region: SnoaL_2; pfam12680
99598015245	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
99598015246	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
99598015247	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
99598015248	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99598015249	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
99598015250	Soluble P-type ATPase [General function prediction only]; Region: COG4087
99598015251	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
99598015252	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
99598015253	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
99598015254	chaperone protein DnaJ; Provisional; Region: PRK14299
99598015255	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99598015256	HSP70 interaction site [polypeptide binding]; other site
99598015257	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
99598015258	substrate binding site [polypeptide binding]; other site
99598015259	dimer interface [polypeptide binding]; other site
99598015260	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
99598015261	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
99598015262	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
99598015263	dimer interface [polypeptide binding]; other site
99598015264	pyruvate kinase; Validated; Region: PRK08187
99598015265	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
99598015266	domain interfaces; other site
99598015267	active site
99598015268	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
99598015269	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
99598015270	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
99598015271	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99598015272	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
99598015273	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99598015274	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
99598015275	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
99598015276	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
99598015277	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
99598015278	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
99598015279	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
99598015280	active site
99598015281	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598015282	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598015283	structural tetrad; other site
99598015284	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598015285	structural tetrad; other site
99598015286	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598015287	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598015288	structural tetrad; other site
99598015289	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
99598015290	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
99598015291	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598015292	FeS/SAM binding site; other site
99598015293	TRAM domain; Region: TRAM; pfam01938
99598015294	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598015295	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598015296	active site
99598015297	ATP binding site [chemical binding]; other site
99598015298	substrate binding site [chemical binding]; other site
99598015299	activation loop (A-loop); other site
99598015300	Uncharacterized conserved protein [Function unknown]; Region: COG1262
99598015301	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
99598015302	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
99598015303	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
99598015304	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598015305	ATP binding site [chemical binding]; other site
99598015306	ATP binding site [chemical binding]; other site
99598015307	putative Mg++ binding site [ion binding]; other site
99598015308	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598015309	nucleotide binding region [chemical binding]; other site
99598015310	ATP-binding site [chemical binding]; other site
99598015311	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
99598015312	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
99598015313	pyrroline-5-carboxylate reductase; Region: PLN02688
99598015314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
99598015315	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
99598015316	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
99598015317	catalytic residue [active]
99598015318	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
99598015319	anthranilate synthase component I-like protein; Validated; Region: PRK05940
99598015320	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
99598015321	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
99598015322	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
99598015323	GTP-binding protein Der; Reviewed; Region: PRK00093
99598015324	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
99598015325	G1 box; other site
99598015326	GTP/Mg2+ binding site [chemical binding]; other site
99598015327	Switch I region; other site
99598015328	G2 box; other site
99598015329	Switch II region; other site
99598015330	G3 box; other site
99598015331	G4 box; other site
99598015332	G5 box; other site
99598015333	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
99598015334	G1 box; other site
99598015335	GTP/Mg2+ binding site [chemical binding]; other site
99598015336	Switch I region; other site
99598015337	G2 box; other site
99598015338	G3 box; other site
99598015339	Switch II region; other site
99598015340	G4 box; other site
99598015341	G5 box; other site
99598015342	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598015343	putative active site [active]
99598015344	membrane protein; Provisional; Region: PRK14419
99598015345	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
99598015346	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
99598015347	Permease; Region: Permease; cl00510
99598015348	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
99598015349	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
99598015350	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
99598015351	tandem repeat interface [polypeptide binding]; other site
99598015352	oligomer interface [polypeptide binding]; other site
99598015353	active site residues [active]
99598015354	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
99598015355	homotrimer interaction site [polypeptide binding]; other site
99598015356	active site
99598015357	PBP superfamily domain; Region: PBP_like_2; cl17296
99598015358	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
99598015359	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598015360	active site
99598015361	ATP binding site [chemical binding]; other site
99598015362	substrate binding site [chemical binding]; other site
99598015363	activation loop (A-loop); other site
99598015364	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
99598015365	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
99598015366	Fasciclin domain; Region: Fasciclin; pfam02469
99598015367	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
99598015368	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
99598015369	C-terminal domain interface [polypeptide binding]; other site
99598015370	GSH binding site (G-site) [chemical binding]; other site
99598015371	dimer interface [polypeptide binding]; other site
99598015372	C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193
99598015373	putative N-terminal domain interface [polypeptide binding]; other site
99598015374	HAS barrel domain; Region: HAS-barrel; pfam09378
99598015375	HerA helicase [Replication, recombination, and repair]; Region: COG0433
99598015376	Domain of unknown function DUF87; Region: DUF87; pfam01935
99598015377	RNA polymerase sigma factor; Validated; Region: PRK05949
99598015378	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
99598015379	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99598015380	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
99598015381	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99598015382	DNA binding residues [nucleotide binding]
99598015383	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
99598015384	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
99598015385	Caspase domain; Region: Peptidase_C14; pfam00656
99598015386	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598015387	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598015388	structural tetrad; other site
99598015389	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598015390	structural tetrad; other site
99598015391	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
99598015392	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
99598015393	active site
99598015394	ribulose/triose binding site [chemical binding]; other site
99598015395	phosphate binding site [ion binding]; other site
99598015396	substrate (anthranilate) binding pocket [chemical binding]; other site
99598015397	product (indole) binding pocket [chemical binding]; other site
99598015398	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598015399	putative active site [active]
99598015400	heme pocket [chemical binding]; other site
99598015401	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598015402	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598015403	dimer interface [polypeptide binding]; other site
99598015404	phosphorylation site [posttranslational modification]
99598015405	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598015406	ATP binding site [chemical binding]; other site
99598015407	Mg2+ binding site [ion binding]; other site
99598015408	G-X-G motif; other site
99598015409	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598015410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598015411	active site
99598015412	phosphorylation site [posttranslational modification]
99598015413	intermolecular recognition site; other site
99598015414	dimerization interface [polypeptide binding]; other site
99598015415	Helix-turn-helix domain; Region: HTH_18; pfam12833
99598015416	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99598015417	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
99598015418	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
99598015419	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
99598015420	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
99598015421	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
99598015422	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598015423	S-adenosylmethionine binding site [chemical binding]; other site
99598015424	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
99598015425	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
99598015426	putative active site [active]
99598015427	putative nucleic acid binding site [nucleotide binding]; other site
99598015428	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
99598015429	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598015430	putative active site [active]
99598015431	PAS fold; Region: PAS_4; pfam08448
99598015432	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598015433	putative active site [active]
99598015434	heme pocket [chemical binding]; other site
99598015435	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598015436	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598015437	putative active site [active]
99598015438	heme pocket [chemical binding]; other site
99598015439	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598015440	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598015441	putative active site [active]
99598015442	heme pocket [chemical binding]; other site
99598015443	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598015444	putative active site [active]
99598015445	heme pocket [chemical binding]; other site
99598015446	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598015447	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598015448	dimer interface [polypeptide binding]; other site
99598015449	phosphorylation site [posttranslational modification]
99598015450	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598015451	ATP binding site [chemical binding]; other site
99598015452	Mg2+ binding site [ion binding]; other site
99598015453	G-X-G motif; other site
99598015454	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
99598015455	active site
99598015456	catalytic residues [active]
99598015457	DNA binding site [nucleotide binding]
99598015458	Int/Topo IB signature motif; other site
99598015459	TSC-22/dip/bun family; Region: TSC22; pfam01166
99598015460	Sporulation and spore germination; Region: Germane; cl11253
99598015461	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
99598015462	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
99598015463	P-loop; other site
99598015464	Magnesium ion binding site [ion binding]; other site
99598015465	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
99598015466	Transposase; Region: DEDD_Tnp_IS110; pfam01548
99598015467	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
99598015468	NIL domain; Region: NIL; pfam09383
99598015469	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
99598015470	putative acetyltransferase; Provisional; Region: PRK03624
99598015471	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598015472	Coenzyme A binding pocket [chemical binding]; other site
99598015473	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
99598015474	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
99598015475	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598015476	dimer interface [polypeptide binding]; other site
99598015477	conserved gate region; other site
99598015478	putative PBP binding loops; other site
99598015479	ABC-ATPase subunit interface; other site
99598015480	5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128
99598015481	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
99598015482	hinge; other site
99598015483	active site
99598015484	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
99598015485	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
99598015486	dimer interface [polypeptide binding]; other site
99598015487	motif 1; other site
99598015488	active site
99598015489	motif 2; other site
99598015490	motif 3; other site
99598015491	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
99598015492	anticodon binding site; other site
99598015493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293
99598015494	S-layer homology domain; Region: SLH; pfam00395
99598015495	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
99598015496	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
99598015497	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
99598015498	TM-ABC transporter signature motif; other site
99598015499	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
99598015500	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
99598015501	Walker A/P-loop; other site
99598015502	ATP binding site [chemical binding]; other site
99598015503	Q-loop/lid; other site
99598015504	ABC transporter signature motif; other site
99598015505	Walker B; other site
99598015506	D-loop; other site
99598015507	H-loop/switch region; other site
99598015508	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
99598015509	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
99598015510	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
99598015511	putative ligand binding site [chemical binding]; other site
99598015512	Transcriptional regulators [Transcription]; Region: PurR; COG1609
99598015513	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99598015514	DNA binding site [nucleotide binding]
99598015515	domain linker motif; other site
99598015516	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
99598015517	dimerization interface [polypeptide binding]; other site
99598015518	ligand binding site [chemical binding]; other site
99598015519	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
99598015520	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
99598015521	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
99598015522	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
99598015523	Walker A/P-loop; other site
99598015524	ATP binding site [chemical binding]; other site
99598015525	Q-loop/lid; other site
99598015526	ABC transporter signature motif; other site
99598015527	Walker B; other site
99598015528	D-loop; other site
99598015529	H-loop/switch region; other site
99598015530	plastocyanin; Provisional; Region: PRK02710
99598015531	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
99598015532	cytochrome c-550; Provisional; Region: psbV; PRK13618
99598015533	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
99598015534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598015535	dimer interface [polypeptide binding]; other site
99598015536	conserved gate region; other site
99598015537	putative PBP binding loops; other site
99598015538	ABC-ATPase subunit interface; other site
99598015539	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99598015540	dimer interface [polypeptide binding]; other site
99598015541	conserved gate region; other site
99598015542	putative PBP binding loops; other site
99598015543	ABC-ATPase subunit interface; other site
99598015544	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99598015545	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99598015546	DNA binding residues [nucleotide binding]
99598015547	dimerization interface [polypeptide binding]; other site
99598015548	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
99598015549	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
99598015550	hypothetical protein; Provisional; Region: PRK09256
99598015551	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
99598015552	Condensation domain; Region: Condensation; pfam00668
99598015553	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
99598015554	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
99598015555	acyl-activating enzyme (AAE) consensus motif; other site
99598015556	AMP binding site [chemical binding]; other site
99598015557	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
99598015558	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
99598015559	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598015560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598015561	active site
99598015562	phosphorylation site [posttranslational modification]
99598015563	intermolecular recognition site; other site
99598015564	dimerization interface [polypeptide binding]; other site
99598015565	PAS fold; Region: PAS_4; pfam08448
99598015566	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598015567	putative active site [active]
99598015568	heme pocket [chemical binding]; other site
99598015569	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
99598015570	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598015571	putative active site [active]
99598015572	heme pocket [chemical binding]; other site
99598015573	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598015574	dimer interface [polypeptide binding]; other site
99598015575	phosphorylation site [posttranslational modification]
99598015576	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598015577	ATP binding site [chemical binding]; other site
99598015578	Mg2+ binding site [ion binding]; other site
99598015579	G-X-G motif; other site
99598015580	Response regulator receiver domain; Region: Response_reg; pfam00072
99598015581	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598015582	active site
99598015583	phosphorylation site [posttranslational modification]
99598015584	intermolecular recognition site; other site
99598015585	dimerization interface [polypeptide binding]; other site
99598015586	Response regulator receiver domain; Region: Response_reg; pfam00072
99598015587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598015588	active site
99598015589	phosphorylation site [posttranslational modification]
99598015590	intermolecular recognition site; other site
99598015591	dimerization interface [polypeptide binding]; other site
99598015592	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598015593	GAF domain; Region: GAF; pfam01590
99598015594	PAS fold; Region: PAS_4; pfam08448
99598015595	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598015596	putative active site [active]
99598015597	heme pocket [chemical binding]; other site
99598015598	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598015599	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598015600	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598015601	dimer interface [polypeptide binding]; other site
99598015602	phosphorylation site [posttranslational modification]
99598015603	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598015604	ATP binding site [chemical binding]; other site
99598015605	Mg2+ binding site [ion binding]; other site
99598015606	G-X-G motif; other site
99598015607	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
99598015608	structural tetrad; other site
99598015609	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
99598015610	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
99598015611	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
99598015612	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
99598015613	shikimate binding site; other site
99598015614	NAD(P) binding site [chemical binding]; other site
99598015615	hydrolase, alpha/beta fold family protein; Region: PLN02824
99598015616	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
99598015617	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
99598015618	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
99598015619	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99598015620	catalytic residue [active]
99598015621	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
99598015622	endonuclease III; Region: ENDO3c; smart00478
99598015623	minor groove reading motif; other site
99598015624	helix-hairpin-helix signature motif; other site
99598015625	substrate binding pocket [chemical binding]; other site
99598015626	active site
99598015627	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
99598015628	Predicted transcriptional regulator [Transcription]; Region: COG1959
99598015629	Transcriptional regulator; Region: Rrf2; pfam02082
99598015630	Transcriptional regulator; Region: Rrf2; cl17282
99598015631	RDD family; Region: RDD; pfam06271
99598015632	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
99598015633	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598015634	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598015635	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598015636	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598015637	Putative addiction module component; Region: Unstab_antitox; cl09921
99598015638	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
99598015639	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598015640	putative active site [active]
99598015641	Archaeal ATPase; Region: Arch_ATPase; pfam01637
99598015642	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
99598015643	Predicted metal-binding protein [Function unknown]; Region: COG5469
99598015644	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
99598015645	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
99598015646	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
99598015647	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
99598015648	Uncharacterized conserved protein [Function unknown]; Region: COG1565
99598015649	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
99598015650	active site
99598015651	metal binding site [ion binding]; metal-binding site
99598015652	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
99598015653	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99598015654	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598015655	Walker A/P-loop; other site
99598015656	ATP binding site [chemical binding]; other site
99598015657	Q-loop/lid; other site
99598015658	ABC transporter signature motif; other site
99598015659	Walker B; other site
99598015660	D-loop; other site
99598015661	H-loop/switch region; other site
99598015662	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
99598015663	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
99598015664	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598015665	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598015666	active site
99598015667	substrate binding site [chemical binding]; other site
99598015668	ATP binding site [chemical binding]; other site
99598015669	activation loop (A-loop); other site
99598015670	Uncharacterized conserved protein [Function unknown]; Region: COG5464
99598015671	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
99598015672	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
99598015673	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
99598015674	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598015675	Walker A/P-loop; other site
99598015676	ATP binding site [chemical binding]; other site
99598015677	Q-loop/lid; other site
99598015678	ABC transporter signature motif; other site
99598015679	Walker B; other site
99598015680	D-loop; other site
99598015681	H-loop/switch region; other site
99598015682	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
99598015683	ABC1 family; Region: ABC1; cl17513
99598015684	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
99598015685	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
99598015686	Substrate binding site; other site
99598015687	Cupin domain; Region: Cupin_2; cl17218
99598015688	Transcriptional regulator [Transcription]; Region: LytR; COG1316
99598015689	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
99598015690	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
99598015691	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598015692	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99598015693	Chorismate mutase type II; Region: CM_2; cl00693
99598015694	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
99598015695	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
99598015696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
99598015697	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
99598015698	short chain dehydrogenase; Validated; Region: PRK06182
99598015699	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
99598015700	NADP binding site [chemical binding]; other site
99598015701	active site
99598015702	steroid binding site; other site
99598015703	PBP superfamily domain; Region: PBP_like_2; cl17296
99598015704	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
99598015705	Mechanosensitive ion channel; Region: MS_channel; pfam00924
99598015706	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598015707	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598015708	ligand binding site [chemical binding]; other site
99598015709	flexible hinge region; other site
99598015710	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598015711	dimerization interface [polypeptide binding]; other site
99598015712	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
99598015713	cyclase homology domain; Region: CHD; cd07302
99598015714	nucleotidyl binding site; other site
99598015715	metal binding site [ion binding]; metal-binding site
99598015716	dimer interface [polypeptide binding]; other site
99598015717	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
99598015718	heme-binding site [chemical binding]; other site
99598015719	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598015720	TPR motif; other site
99598015721	binding surface
99598015722	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598015723	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598015724	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598015725	binding surface
99598015726	TPR motif; other site
99598015727	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598015728	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598015729	binding surface
99598015730	TPR motif; other site
99598015731	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598015732	Tetratricopeptide repeat; Region: TPR_12; pfam13424
99598015733	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
99598015734	OmpW family; Region: OmpW; cl17427
99598015735	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
99598015736	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99598015737	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598015738	DevC protein; Region: devC; TIGR01185
99598015739	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
99598015740	FtsX-like permease family; Region: FtsX; pfam02687
99598015741	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
99598015742	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
99598015743	Walker A/P-loop; other site
99598015744	ATP binding site [chemical binding]; other site
99598015745	Q-loop/lid; other site
99598015746	ABC transporter signature motif; other site
99598015747	Walker B; other site
99598015748	D-loop; other site
99598015749	H-loop/switch region; other site
99598015750	Predicted permeases [General function prediction only]; Region: COG0679
99598015751	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
99598015752	Peptidase family M23; Region: Peptidase_M23; pfam01551
99598015753	Late competence development protein ComFB; Region: ComFB; pfam10719
99598015754	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
99598015755	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
99598015756	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
99598015757	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99598015758	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99598015759	DNA binding residues [nucleotide binding]
99598015760	Putative zinc-finger; Region: zf-HC2; pfam13490
99598015761	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
99598015762	putative active site pocket [active]
99598015763	dimerization interface [polypeptide binding]; other site
99598015764	putative catalytic residue [active]
99598015765	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
99598015766	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
99598015767	HIGH motif; other site
99598015768	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
99598015769	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
99598015770	active site
99598015771	KMSKS motif; other site
99598015772	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
99598015773	tRNA binding surface [nucleotide binding]; other site
99598015774	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598015775	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
99598015776	active site
99598015777	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
99598015778	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
99598015779	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
99598015780	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
99598015781	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
99598015782	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598015783	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598015784	active site
99598015785	ATP binding site [chemical binding]; other site
99598015786	substrate binding site [chemical binding]; other site
99598015787	activation loop (A-loop); other site
99598015788	Right handed beta helix region; Region: Beta_helix; pfam13229
99598015789	Right handed beta helix region; Region: Beta_helix; pfam13229
99598015790	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
99598015791	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
99598015792	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
99598015793	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
99598015794	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
99598015795	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
99598015796	C-terminal domain interface [polypeptide binding]; other site
99598015797	glycogen branching enzyme; Provisional; Region: PRK05402
99598015798	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
99598015799	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
99598015800	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
99598015801	active site
99598015802	catalytic site [active]
99598015803	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
99598015804	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99598015805	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
99598015806	active site
99598015807	catalytic tetrad [active]
99598015808	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
99598015809	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
99598015810	active site
99598015811	non-prolyl cis peptide bond; other site
99598015812	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
99598015813	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
99598015814	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
99598015815	Predicted esterase [General function prediction only]; Region: COG0400
99598015816	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
99598015817	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
99598015818	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99598015819	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
99598015820	active site
99598015821	catalytic tetrad [active]
99598015822	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
99598015823	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
99598015824	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99598015825	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598015826	Walker A/P-loop; other site
99598015827	ATP binding site [chemical binding]; other site
99598015828	Q-loop/lid; other site
99598015829	ABC transporter signature motif; other site
99598015830	Walker B; other site
99598015831	D-loop; other site
99598015832	H-loop/switch region; other site
99598015833	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
99598015834	active site
99598015835	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
99598015836	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
99598015837	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
99598015838	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99598015839	catalytic loop [active]
99598015840	iron binding site [ion binding]; other site
99598015841	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
99598015842	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99598015843	catalytic loop [active]
99598015844	iron binding site [ion binding]; other site
99598015845	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
99598015846	Stage II sporulation protein; Region: SpoIID; pfam08486
99598015847	ParB-like nuclease domain; Region: ParBc; cl02129
99598015848	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
99598015849	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
99598015850	dimerization interface [polypeptide binding]; other site
99598015851	DPS ferroxidase diiron center [ion binding]; other site
99598015852	ion pore; other site
99598015853	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
99598015854	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
99598015855	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
99598015856	PAS fold; Region: PAS_4; pfam08448
99598015857	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598015858	putative active site [active]
99598015859	heme pocket [chemical binding]; other site
99598015860	PAS domain S-box; Region: sensory_box; TIGR00229
99598015861	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598015862	putative active site [active]
99598015863	heme pocket [chemical binding]; other site
99598015864	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598015865	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598015866	putative active site [active]
99598015867	heme pocket [chemical binding]; other site
99598015868	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598015869	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598015870	dimer interface [polypeptide binding]; other site
99598015871	phosphorylation site [posttranslational modification]
99598015872	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598015873	ATP binding site [chemical binding]; other site
99598015874	Mg2+ binding site [ion binding]; other site
99598015875	G-X-G motif; other site
99598015876	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
99598015877	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
99598015878	anti sigma factor interaction site; other site
99598015879	regulatory phosphorylation site [posttranslational modification]; other site
99598015880	Response regulator receiver domain; Region: Response_reg; pfam00072
99598015881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598015882	active site
99598015883	phosphorylation site [posttranslational modification]
99598015884	intermolecular recognition site; other site
99598015885	dimerization interface [polypeptide binding]; other site
99598015886	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
99598015887	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
99598015888	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
99598015889	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598015890	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598015891	active site
99598015892	ATP binding site [chemical binding]; other site
99598015893	substrate binding site [chemical binding]; other site
99598015894	activation loop (A-loop); other site
99598015895	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
99598015896	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598015897	dimerization interface [polypeptide binding]; other site
99598015898	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
99598015899	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99598015900	membrane-bound complex binding site; other site
99598015901	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
99598015902	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
99598015903	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598015904	putative active site [active]
99598015905	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99598015906	oligomeric interface; other site
99598015907	putative active site [active]
99598015908	homodimer interface [polypeptide binding]; other site
99598015909	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
99598015910	PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744
99598015911	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598015912	putative active site [active]
99598015913	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598015914	non-specific DNA binding site [nucleotide binding]; other site
99598015915	salt bridge; other site
99598015916	sequence-specific DNA binding site [nucleotide binding]; other site
99598015917	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
99598015918	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
99598015919	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
99598015920	Walker A/P-loop; other site
99598015921	ATP binding site [chemical binding]; other site
99598015922	Q-loop/lid; other site
99598015923	ABC transporter signature motif; other site
99598015924	Walker B; other site
99598015925	D-loop; other site
99598015926	H-loop/switch region; other site
99598015927	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598015928	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598015929	active site
99598015930	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598015931	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
99598015932	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
99598015933	inhibitor-cofactor binding pocket; inhibition site
99598015934	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598015935	catalytic residue [active]
99598015936	Methyltransferase domain; Region: Methyltransf_31; pfam13847
99598015937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598015938	S-adenosylmethionine binding site [chemical binding]; other site
99598015939	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598015940	GNT-I family; Region: GNT-I; pfam03071
99598015941	Methyltransferase domain; Region: Methyltransf_23; pfam13489
99598015942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99598015943	S-adenosylmethionine binding site [chemical binding]; other site
99598015944	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598015945	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
99598015946	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598015947	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598015948	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
99598015949	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598015950	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598015951	active site
99598015952	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99598015953	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598015954	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598015955	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598015956	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99598015957	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598015958	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99598015959	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99598015960	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
99598015961	Protein of unknown function (DUF563); Region: DUF563; pfam04577
99598015962	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
99598015963	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598015964	ATP binding site [chemical binding]; other site
99598015965	putative Mg++ binding site [ion binding]; other site
99598015966	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598015967	nucleotide binding region [chemical binding]; other site
99598015968	ATP-binding site [chemical binding]; other site
99598015969	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
99598015970	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
99598015971	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99598015972	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
99598015973	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
99598015974	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598015975	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
99598015976	Walker A motif; other site
99598015977	ATP binding site [chemical binding]; other site
99598015978	Walker B motif; other site
99598015979	arginine finger; other site
99598015980	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
99598015981	metal ion-dependent adhesion site (MIDAS); other site
99598015982	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
99598015983	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99598015984	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
99598015985	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99598015986	DNA binding residues [nucleotide binding]
99598015987	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
99598015988	peptide chain release factor 2; Validated; Region: prfB; PRK00578
99598015989	This domain is found in peptide chain release factors; Region: PCRF; smart00937
99598015990	RF-1 domain; Region: RF-1; pfam00472
99598015991	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
99598015992	metal-binding heat shock protein; Provisional; Region: PRK00016
99598015993	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
99598015994	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
99598015995	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
99598015996	glutamine binding [chemical binding]; other site
99598015997	catalytic triad [active]
99598015998	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
99598015999	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
99598016000	Family description; Region: VCBS; pfam13517
99598016001	Family description; Region: VCBS; pfam13517
99598016002	Family description; Region: VCBS; pfam13517
99598016003	Family description; Region: VCBS; pfam13517
99598016004	proline aminopeptidase P II; Provisional; Region: PRK10879
99598016005	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
99598016006	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
99598016007	active site
99598016008	SnoaL-like domain; Region: SnoaL_2; pfam12680
99598016009	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598016010	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598016011	structural tetrad; other site
99598016012	FOG: WD40 repeat [General function prediction only]; Region: COG2319
99598016013	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
99598016014	structural tetrad; other site
99598016015	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
99598016016	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99598016017	non-specific DNA binding site [nucleotide binding]; other site
99598016018	salt bridge; other site
99598016019	sequence-specific DNA binding site [nucleotide binding]; other site
99598016020	AAA ATPase domain; Region: AAA_16; pfam13191
99598016021	DNA polymerase III subunit delta'; Validated; Region: PRK07940
99598016022	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
99598016023	cell division protein; Validated; Region: ftsH; CHL00176
99598016024	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99598016025	Walker A motif; other site
99598016026	ATP binding site [chemical binding]; other site
99598016027	Walker B motif; other site
99598016028	arginine finger; other site
99598016029	Peptidase family M41; Region: Peptidase_M41; pfam01434
99598016030	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
99598016031	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
99598016032	HIGH motif; other site
99598016033	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
99598016034	active site
99598016035	KMSKS motif; other site
99598016036	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
99598016037	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598016038	active site
99598016039	ATP binding site [chemical binding]; other site
99598016040	substrate binding site [chemical binding]; other site
99598016041	activation loop (A-loop); other site
99598016042	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
99598016043	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598016044	active site
99598016045	ATP binding site [chemical binding]; other site
99598016046	substrate binding site [chemical binding]; other site
99598016047	activation loop (A-loop); other site
99598016048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
99598016049	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
99598016050	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
99598016051	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
99598016052	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598016053	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
99598016054	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
99598016055	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
99598016056	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99598016057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598016058	active site
99598016059	phosphorylation site [posttranslational modification]
99598016060	intermolecular recognition site; other site
99598016061	dimerization interface [polypeptide binding]; other site
99598016062	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99598016063	DNA binding site [nucleotide binding]
99598016064	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
99598016065	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598016066	dimer interface [polypeptide binding]; other site
99598016067	phosphorylation site [posttranslational modification]
99598016068	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598016069	ATP binding site [chemical binding]; other site
99598016070	Mg2+ binding site [ion binding]; other site
99598016071	G-X-G motif; other site
99598016072	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
99598016073	RNase_H superfamily; Region: RNase_H_2; pfam13482
99598016074	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
99598016075	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
99598016076	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99598016077	catalytic residue [active]
99598016078	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598016079	putative active site [active]
99598016080	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
99598016081	Uncharacterized conserved protein [Function unknown]; Region: COG0432
99598016082	TIR domain; Region: TIR_2; pfam13676
99598016083	Uncharacterized conserved protein [Function unknown]; Region: COG1262
99598016084	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
99598016085	Uncharacterized conserved protein [Function unknown]; Region: COG0327
99598016086	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
99598016087	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
99598016088	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
99598016089	NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180
99598016090	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
99598016091	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
99598016092	ATP binding site [chemical binding]; other site
99598016093	Mg++ binding site [ion binding]; other site
99598016094	motif III; other site
99598016095	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598016096	nucleotide binding region [chemical binding]; other site
99598016097	ATP-binding site [chemical binding]; other site
99598016098	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99598016099	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
99598016100	HSP70 interaction site [polypeptide binding]; other site
99598016101	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598016102	Clp protease; Region: CLP_protease; pfam00574
99598016103	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
99598016104	oligomer interface [polypeptide binding]; other site
99598016105	active site residues [active]
99598016106	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
99598016107	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
99598016108	oligomer interface [polypeptide binding]; other site
99598016109	active site residues [active]
99598016110	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
99598016111	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
99598016112	metal ion-dependent adhesion site (MIDAS); other site
99598016113	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
99598016114	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
99598016115	metal ion-dependent adhesion site (MIDAS); other site
99598016116	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
99598016117	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
99598016118	putative metal binding site [ion binding]; other site
99598016119	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
99598016120	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99598016121	Coenzyme A binding pocket [chemical binding]; other site
99598016122	Uncharacterized conserved protein [Function unknown]; Region: COG5464
99598016123	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
99598016124	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
99598016125	putative active site [active]
99598016126	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
99598016127	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99598016128	FeS/SAM binding site; other site
99598016129	HemN C-terminal domain; Region: HemN_C; pfam06969
99598016130	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
99598016131	PemK-like protein; Region: PemK; pfam02452
99598016132	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
99598016133	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
99598016134	diaminopimelate epimerase; Region: PLN02536
99598016135	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
99598016136	Sm and related proteins; Region: Sm_like; cl00259
99598016137	heptamer interface [polypeptide binding]; other site
99598016138	Sm1 motif; other site
99598016139	hexamer interface [polypeptide binding]; other site
99598016140	RNA binding site [nucleotide binding]; other site
99598016141	Sm2 motif; other site
99598016142	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
99598016143	putative cation:proton antiport protein; Provisional; Region: PRK10669
99598016144	TrkA-N domain; Region: TrkA_N; pfam02254
99598016145	TrkA-C domain; Region: TrkA_C; pfam02080
99598016146	TrkA-C domain; Region: TrkA_C; pfam02080
99598016147	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
99598016148	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
99598016149	putative ADP-binding pocket [chemical binding]; other site
99598016150	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
99598016151	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
99598016152	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402
99598016153	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99598016154	HSP70 interaction site [polypeptide binding]; other site
99598016155	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
99598016156	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
99598016157	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
99598016158	tetramer interface [polypeptide binding]; other site
99598016159	TPP-binding site [chemical binding]; other site
99598016160	heterodimer interface [polypeptide binding]; other site
99598016161	phosphorylation loop region [posttranslational modification]
99598016162	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
99598016163	active site
99598016164	catalytic residues [active]
99598016165	EamA-like transporter family; Region: EamA; pfam00892
99598016166	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
99598016167	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
99598016168	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
99598016169	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
99598016170	G1 box; other site
99598016171	GTP/Mg2+ binding site [chemical binding]; other site
99598016172	Switch I region; other site
99598016173	G2 box; other site
99598016174	Switch II region; other site
99598016175	G3 box; other site
99598016176	G4 box; other site
99598016177	G5 box; other site
99598016178	Domain of unknown function (DUF697); Region: DUF697; pfam05128
99598016179	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598016180	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598016181	active site
99598016182	ATP binding site [chemical binding]; other site
99598016183	substrate binding site [chemical binding]; other site
99598016184	activation loop (A-loop); other site
99598016185	Protein kinase domain; Region: Pkinase; pfam00069
99598016186	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598016187	active site
99598016188	ATP binding site [chemical binding]; other site
99598016189	substrate binding site [chemical binding]; other site
99598016190	activation loop (A-loop); other site
99598016191	TPR repeat; Region: TPR_11; pfam13414
99598016192	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598016193	binding surface
99598016194	TPR motif; other site
99598016195	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
99598016196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598016197	binding surface
99598016198	TPR motif; other site
99598016199	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598016200	binding surface
99598016201	TPR motif; other site
99598016202	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598016203	binding surface
99598016204	TPR motif; other site
99598016205	HD domain; Region: HD_4; pfam13328
99598016206	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
99598016207	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
99598016208	dimerization interface [polypeptide binding]; other site
99598016209	active site
99598016210	DNA-directed RNA polymerase subunit A' Region: RNA_pol_rpoA1; TIGR02390
99598016211	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
99598016212	metal ion-dependent adhesion site (MIDAS); other site
99598016213	ThiF family; Region: ThiF; pfam00899
99598016214	ATP binding site [chemical binding]; other site
99598016215	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598016216	putative active site [active]
99598016217	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
99598016218	arginine-tRNA ligase; Region: PLN02286
99598016219	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
99598016220	active site
99598016221	HIGH motif; other site
99598016222	KMSK motif region; other site
99598016223	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
99598016224	tRNA binding surface [nucleotide binding]; other site
99598016225	anticodon binding site; other site
99598016226	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
99598016227	homotrimer interface [polypeptide binding]; other site
99598016228	Walker A motif; other site
99598016229	GTP binding site [chemical binding]; other site
99598016230	Walker B motif; other site
99598016231	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
99598016232	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99598016233	active site
99598016234	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99598016235	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
99598016236	putative metal binding site; other site
99598016237	putative acyl transferase; Provisional; Region: PRK10502
99598016238	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
99598016239	putative trimer interface [polypeptide binding]; other site
99598016240	putative active site [active]
99598016241	putative substrate binding site [chemical binding]; other site
99598016242	putative CoA binding site [chemical binding]; other site
99598016243	Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899
99598016244	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598016245	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99598016246	ligand binding site [chemical binding]; other site
99598016247	flexible hinge region; other site
99598016248	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
99598016249	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
99598016250	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
99598016251	4Fe-4S binding domain; Region: Fer4_5; pfam12801
99598016252	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
99598016253	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
99598016254	putative ADP-binding pocket [chemical binding]; other site
99598016255	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
99598016256	Domain of unknown function (DUF814); Region: DUF814; pfam05670
99598016257	S-layer homology domain; Region: SLH; pfam00395
99598016258	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
99598016259	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
99598016260	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
99598016261	intersubunit interface [polypeptide binding]; other site
99598016262	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
99598016263	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
99598016264	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
99598016265	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
99598016266	ABC-ATPase subunit  interface; other site
99598016267	dimer interface [polypeptide binding]; other site
99598016268	putative PBP binding regions; other site
99598016269	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
99598016270	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
99598016271	homodimer interface [polypeptide binding]; other site
99598016272	substrate-cofactor binding pocket; other site
99598016273	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598016274	catalytic residue [active]
99598016275	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
99598016276	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
99598016277	dimer interface [polypeptide binding]; other site
99598016278	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598016279	catalytic residue [active]
99598016280	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
99598016281	aminotransferase family protein; Provisional; Region: PLN00175
99598016282	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99598016283	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99598016284	homodimer interface [polypeptide binding]; other site
99598016285	catalytic residue [active]
99598016286	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
99598016287	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
99598016288	uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792
99598016289	Uncharacterized conserved protein [Function unknown]; Region: COG3937
99598016290	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
99598016291	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
99598016292	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598016293	dimer interface [polypeptide binding]; other site
99598016294	phosphorylation site [posttranslational modification]
99598016295	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
99598016296	Mg2+ binding site [ion binding]; other site
99598016297	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
99598016298	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598016299	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
99598016300	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
99598016301	NAD(P) binding site [chemical binding]; other site
99598016302	putative active site [active]
99598016303	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
99598016304	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
99598016305	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
99598016306	putative acyl-acceptor binding pocket; other site
99598016307	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
99598016308	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
99598016309	active site
99598016310	HIGH motif; other site
99598016311	KMSKS motif; other site
99598016312	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
99598016313	anticodon binding site; other site
99598016314	tRNA binding surface [nucleotide binding]; other site
99598016315	Uncharacterized conserved protein [Function unknown]; Region: COG1432
99598016316	LabA_like proteins; Region: LabA; cd10911
99598016317	putative metal binding site [ion binding]; other site
99598016318	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
99598016319	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
99598016320	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
99598016321	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
99598016322	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
99598016323	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
99598016324	catalytic residues [active]
99598016325	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
99598016326	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
99598016327	active site
99598016328	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
99598016329	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
99598016330	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
99598016331	MutS domain III; Region: MutS_III; pfam05192
99598016332	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99598016333	Walker A/P-loop; other site
99598016334	ATP binding site [chemical binding]; other site
99598016335	Q-loop/lid; other site
99598016336	ABC transporter signature motif; other site
99598016337	Walker B; other site
99598016338	D-loop; other site
99598016339	H-loop/switch region; other site
99598016340	Smr domain; Region: Smr; pfam01713
99598016341	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
99598016342	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
99598016343	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4298
99598016344	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
99598016345	Ycf35; Provisional; Region: ycf35; CHL00193
99598016346	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
99598016347	Cupin domain; Region: Cupin_2; cl17218
99598016348	Domain of unknown function DUF29; Region: DUF29; pfam01724
99598016349	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598016350	putative active site [active]
99598016351	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
99598016352	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
99598016353	Walker A motif; other site
99598016354	ATP binding site [chemical binding]; other site
99598016355	Walker B motif; other site
99598016356	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
99598016357	Protein of unknown function DUF58; Region: DUF58; pfam01882
99598016358	ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165
99598016359	Domain of unknown function (DUF309); Region: DUF309; pfam03745
99598016360	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
99598016361	OstA-like protein; Region: OstA; cl00844
99598016362	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
99598016363	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
99598016364	Walker A/P-loop; other site
99598016365	ATP binding site [chemical binding]; other site
99598016366	Q-loop/lid; other site
99598016367	ABC transporter signature motif; other site
99598016368	Walker B; other site
99598016369	D-loop; other site
99598016370	H-loop/switch region; other site
99598016371	Predicted permeases [General function prediction only]; Region: COG0795
99598016372	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
99598016373	FOG: CBS domain [General function prediction only]; Region: COG0517
99598016374	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
99598016375	CP12 domain; Region: CP12; pfam02672
99598016376	Predicted integral membrane protein [Function unknown]; Region: COG3548
99598016377	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
99598016378	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
99598016379	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
99598016380	putative active site [active]
99598016381	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
99598016382	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
99598016383	Protein of unknown function (DUF433); Region: DUF433; pfam04255
99598016384	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
99598016385	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
99598016386	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99598016387	ATP binding site [chemical binding]; other site
99598016388	putative Mg++ binding site [ion binding]; other site
99598016389	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99598016390	nucleotide binding region [chemical binding]; other site
99598016391	ATP-binding site [chemical binding]; other site
99598016392	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
99598016393	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
99598016394	Domain of unknown function DUF21; Region: DUF21; pfam01595
99598016395	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
99598016396	Transporter associated domain; Region: CorC_HlyC; smart01091
99598016397	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
99598016398	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99598016399	active site
99598016400	catalytic tetrad [active]
99598016401	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
99598016402	NAD(P) binding pocket [chemical binding]; other site
99598016403	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
99598016404	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
99598016405	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
99598016406	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
99598016407	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
99598016408	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
99598016409	CHAT domain; Region: CHAT; cl17868
99598016410	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
99598016411	CHASE2 domain; Region: CHASE2; pfam05226
99598016412	MFS/sugar transport protein; Region: MFS_2; pfam13347
99598016413	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
99598016414	Heme NO binding; Region: HNOB; pfam07700
99598016415	Heme NO binding associated; Region: HNOBA; pfam07701
99598016416	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598016417	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598016418	dimer interface [polypeptide binding]; other site
99598016419	phosphorylation site [posttranslational modification]
99598016420	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598016421	ATP binding site [chemical binding]; other site
99598016422	Mg2+ binding site [ion binding]; other site
99598016423	G-X-G motif; other site
99598016424	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
99598016425	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
99598016426	Walker A/P-loop; other site
99598016427	ATP binding site [chemical binding]; other site
99598016428	Q-loop/lid; other site
99598016429	ABC transporter signature motif; other site
99598016430	Walker B; other site
99598016431	D-loop; other site
99598016432	H-loop/switch region; other site
99598016433	TOBE domain; Region: TOBE_2; pfam08402
99598016434	Protein of unknown function (DUF497); Region: DUF497; pfam04365
99598016435	GUN4-like; Region: GUN4; pfam05419
99598016436	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
99598016437	isocitrate dehydrogenase; Validated; Region: PRK07362
99598016438	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
99598016439	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
99598016440	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
99598016441	Protein kinase domain; Region: Pkinase; pfam00069
99598016442	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598016443	active site
99598016444	ATP binding site [chemical binding]; other site
99598016445	substrate binding site [chemical binding]; other site
99598016446	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
99598016447	substrate binding site [chemical binding]; other site
99598016448	activation loop (A-loop); other site
99598016449	activation loop (A-loop); other site
99598016450	AAA ATPase domain; Region: AAA_16; pfam13191
99598016451	Predicted ATPase [General function prediction only]; Region: COG3899
99598016452	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598016453	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598016454	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598016455	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598016456	ATP binding site [chemical binding]; other site
99598016457	Mg2+ binding site [ion binding]; other site
99598016458	G-X-G motif; other site
99598016459	Protein kinase domain; Region: Pkinase; pfam00069
99598016460	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598016461	active site
99598016462	ATP binding site [chemical binding]; other site
99598016463	substrate binding site [chemical binding]; other site
99598016464	substrate binding site [chemical binding]; other site
99598016465	activation loop (A-loop); other site
99598016466	activation loop (A-loop); other site
99598016467	AAA ATPase domain; Region: AAA_16; pfam13191
99598016468	Predicted ATPase [General function prediction only]; Region: COG3899
99598016469	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598016470	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598016471	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598016472	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598016473	dimer interface [polypeptide binding]; other site
99598016474	phosphorylation site [posttranslational modification]
99598016475	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598016476	ATP binding site [chemical binding]; other site
99598016477	Mg2+ binding site [ion binding]; other site
99598016478	G-X-G motif; other site
99598016479	Protein kinase domain; Region: Pkinase; pfam00069
99598016480	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598016481	active site
99598016482	ATP binding site [chemical binding]; other site
99598016483	substrate binding site [chemical binding]; other site
99598016484	substrate binding site [chemical binding]; other site
99598016485	activation loop (A-loop); other site
99598016486	activation loop (A-loop); other site
99598016487	AAA ATPase domain; Region: AAA_16; pfam13191
99598016488	Predicted ATPase [General function prediction only]; Region: COG3899
99598016489	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598016490	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598016491	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598016492	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598016493	ATP binding site [chemical binding]; other site
99598016494	Mg2+ binding site [ion binding]; other site
99598016495	G-X-G motif; other site
99598016496	Protein kinase domain; Region: Pkinase; pfam00069
99598016497	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598016498	active site
99598016499	ATP binding site [chemical binding]; other site
99598016500	substrate binding site [chemical binding]; other site
99598016501	activation loop (A-loop); other site
99598016502	AAA ATPase domain; Region: AAA_16; pfam13191
99598016503	Predicted ATPase [General function prediction only]; Region: COG3899
99598016504	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598016505	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598016506	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
99598016507	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598016508	putative active site [active]
99598016509	heme pocket [chemical binding]; other site
99598016510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598016511	ATP binding site [chemical binding]; other site
99598016512	Mg2+ binding site [ion binding]; other site
99598016513	G-X-G motif; other site
99598016514	Protein kinase domain; Region: Pkinase; pfam00069
99598016515	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598016516	active site
99598016517	ATP binding site [chemical binding]; other site
99598016518	substrate binding site [chemical binding]; other site
99598016519	substrate binding site [chemical binding]; other site
99598016520	activation loop (A-loop); other site
99598016521	activation loop (A-loop); other site
99598016522	AAA ATPase domain; Region: AAA_16; pfam13191
99598016523	Predicted ATPase [General function prediction only]; Region: COG3899
99598016524	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
99598016525	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598016526	GAF domain; Region: GAF; pfam01590
99598016527	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598016528	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598016529	dimer interface [polypeptide binding]; other site
99598016530	phosphorylation site [posttranslational modification]
99598016531	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598016532	ATP binding site [chemical binding]; other site
99598016533	Mg2+ binding site [ion binding]; other site
99598016534	G-X-G motif; other site
99598016535	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
99598016536	Catalytic domain of Protein Kinases; Region: PKc; cd00180
99598016537	active site
99598016538	ATP binding site [chemical binding]; other site
99598016539	substrate binding site [chemical binding]; other site
99598016540	activation loop (A-loop); other site
99598016541	AAA ATPase domain; Region: AAA_16; pfam13191
99598016542	Predicted ATPase [General function prediction only]; Region: COG3899
99598016543	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
99598016544	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99598016545	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99598016546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598016547	ATP binding site [chemical binding]; other site
99598016548	Mg2+ binding site [ion binding]; other site
99598016549	G-X-G motif; other site
99598016550	Uncharacterized conserved protein [Function unknown]; Region: COG3287
99598016551	FIST N domain; Region: FIST; pfam08495
99598016552	FIST C domain; Region: FIST_C; pfam10442
99598016553	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
99598016554	dimer interface [polypeptide binding]; other site
99598016555	phosphorylation site [posttranslational modification]
99598016556	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598016557	ATP binding site [chemical binding]; other site
99598016558	Mg2+ binding site [ion binding]; other site
99598016559	G-X-G motif; other site
99598016560	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
99598016561	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
99598016562	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
99598016563	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
99598016564	Walker A/P-loop; other site
99598016565	ATP binding site [chemical binding]; other site
99598016566	Q-loop/lid; other site
99598016567	ABC transporter signature motif; other site
99598016568	Walker B; other site
99598016569	D-loop; other site
99598016570	H-loop/switch region; other site
99598016571	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
99598016572	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99598016573	TPR motif; other site
99598016574	binding surface
99598016575	Tetratricopeptide repeat; Region: TPR_16; pfam13432
99598016576	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
99598016577	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
99598016578	nudix motif; other site
99598016579	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
99598016580	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
99598016581	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
99598016582	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
99598016583	Probable transposase; Region: OrfB_IS605; pfam01385
99598016584	Protein of unknown function (DUF4090); Region: DUF4090; pfam13319
99598016585	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
99598016586	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
99598016587	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
99598016588	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
99598016589	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
99598016590	protein I interface; other site
99598016591	D2 interface; other site
99598016592	protein T interface; other site
99598016593	chlorophyll binding site; other site
99598016594	beta carotene binding site; other site
99598016595	pheophytin binding site; other site
99598016596	manganese-stabilizing polypeptide interface; other site
99598016597	CP43 interface; other site
99598016598	protein L interface; other site
99598016599	oxygen evolving complex binding site; other site
99598016600	bromide binding site; other site
99598016601	quinone binding site; other site
99598016602	Fe binding site [ion binding]; other site
99598016603	core light harvesting interface; other site
99598016604	cytochrome b559 alpha subunit interface; other site
99598016605	cytochrome c-550 interface; other site
99598016606	protein J interface; other site
99598016607	PsbP; Region: PsbP; pfam01789
99598016608	Maf-like protein; Region: Maf; pfam02545
99598016609	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
99598016610	active site
99598016611	dimer interface [polypeptide binding]; other site
99598016612	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
99598016613	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
99598016614	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99598016615	HlyD family secretion protein; Region: HlyD_3; pfam13437
99598016616	DevC protein; Region: devC; TIGR01185
99598016617	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
99598016618	FtsX-like permease family; Region: FtsX; pfam02687
99598016619	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
99598016620	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
99598016621	Walker A/P-loop; other site
99598016622	ATP binding site [chemical binding]; other site
99598016623	Q-loop/lid; other site
99598016624	ABC transporter signature motif; other site
99598016625	Walker B; other site
99598016626	D-loop; other site
99598016627	H-loop/switch region; other site
99598016628	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
99598016629	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99598016630	active site
99598016631	motif I; other site
99598016632	motif II; other site
99598016633	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
99598016634	putative active site [active]
99598016635	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
99598016636	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
99598016637	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
99598016638	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99598016639	dimerization interface [polypeptide binding]; other site
99598016640	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
99598016641	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
99598016642	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99598016643	putative active site [active]
99598016644	heme pocket [chemical binding]; other site
99598016645	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99598016646	dimer interface [polypeptide binding]; other site
99598016647	phosphorylation site [posttranslational modification]
99598016648	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99598016649	ATP binding site [chemical binding]; other site
99598016650	Mg2+ binding site [ion binding]; other site
99598016651	G-X-G motif; other site
99598016652	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
99598016653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99598016654	active site
99598016655	phosphorylation site [posttranslational modification]
99598016656	intermolecular recognition site; other site
99598016657	dimerization interface [polypeptide binding]; other site
99598016658	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99598016659	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
99598016660	putative switch regulator; other site
99598016661	non-specific DNA interactions [nucleotide binding]; other site
99598016662	DNA binding site [nucleotide binding]
99598016663	sequence specific DNA binding site [nucleotide binding]; other site
99598016664	putative cAMP binding site [chemical binding]; other site
99598016665	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
99598016666	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
99598016667	metal binding site 2 [ion binding]; metal-binding site
99598016668	putative DNA binding helix; other site
99598016669	metal binding site 1 [ion binding]; metal-binding site
99598016670	dimer interface [polypeptide binding]; other site
99598016671	structural Zn2+ binding site [ion binding]; other site
99598016672	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
99598016673	catalytic triad [active]
99598016674	dimer interface [polypeptide binding]; other site
99598016675	glutathione reductase; Validated; Region: PRK06116
99598016676	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
99598016677	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99598016678	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
99598016679	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
99598016680	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
99598016681	active site
99598016682	catalytic residues [active]
99598016683	metal binding site [ion binding]; metal-binding site
99598016684	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
99598016685	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
99598016686	protein binding site [polypeptide binding]; other site