-- dump date 20140619_021341 -- class Genbank::CDS -- table cds_note -- id note YP_891211.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_891212.1 binds the polymerase to DNA and acts as a sliding clamp YP_891213.1 negatively supercoils closed circular double-stranded DNA YP_891214.1 identified by match to protein family HMM PF00563 YP_891215.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis YP_891218.1 identified by match to protein family HMM PF06429 YP_891219.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod YP_891221.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710 YP_891223.1 identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394 YP_891226.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_891227.1 identified by match to protein family HMM PF04332 YP_891228.1 identified by match to protein family HMM PF00005 YP_891230.1 identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297 YP_891231.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_891232.1 identified by match to protein family HMM PF04095 YP_891234.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR02495 YP_891235.1 identified by match to protein family HMM PF03498 YP_891236.1 identified by match to protein family HMM PF03372 YP_891237.1 identified by match to protein family HMM PF03498 YP_891238.1 identified by match to protein family HMM TIGR02532 YP_891239.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_891240.1 identified by match to protein family HMM PF00795 YP_891241.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins YP_891242.1 identified by match to protein family HMM PF00081; match to protein family HMM PF02777 YP_891243.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_891244.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_891245.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_891246.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_891247.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_891248.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_891249.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_891250.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_891251.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_891252.1 one of the stabilizing components for the large ribosomal subunit YP_891253.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_891254.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_891255.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_891256.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_891257.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_891258.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_891259.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_891260.1 binds 5S rRNA along with protein L5 and L25 YP_891261.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_891262.1 late assembly protein YP_891263.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_891264.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_891265.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_891266.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_891267.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_891268.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_891269.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_891270.1 is a component of the macrolide binding site in the peptidyl transferase center YP_891271.1 identified by match to protein family HMM PF01106 YP_891273.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_891274.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_891275.1 identified by match to protein family HMM PF00015 YP_891276.1 identified by match to protein family HMM PF02575; match to protein family HMM TIGR00103 YP_891278.1 identified by match to protein family HMM PF00348 YP_891279.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_891280.1 NAD-linked YP_891281.1 identified by match to protein family HMM PF04328 YP_891282.1 identified by match to protein family HMM PF02554 YP_891283.1 identified by match to protein family HMM PF02597; match to protein family HMM TIGR01683 YP_891284.1 catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate YP_891285.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_891286.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center YP_891287.1 identified by match to protein family HMM PF01205 YP_891288.1 identified by match to protein family HMM PF00483; match to protein family HMM TIGR01099 YP_891289.1 catalyzes the formation of D-fructose 6-phosphate from D-glucose 6-phosphate YP_891290.1 identified by match to protein family HMM PF00210 YP_891291.1 identified by match to protein family HMM PF04264 YP_891293.1 identified by match to protein family HMM TIGR00347 YP_891295.1 identified by match to protein family HMM PF04301 YP_891296.1 identified by match to protein family HMM PF00155 YP_891298.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_891299.1 catalyzes the modification of U13 in tRNA(Glu) YP_891301.1 flagellin specific chaperone YP_891302.1 Also called hook-associated protein 2; involved in flagellin assembly YP_891303.1 possibly involved in flagella export YP_891305.1 identified by match to protein family HMM PF03602; match to protein family HMM TIGR00095 YP_891306.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_891310.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_891311.1 identified by match to protein family HMM TIGR02757 YP_891312.1 identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880 YP_891313.1 identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM TIGR01479 YP_891314.1 identified by match to protein family HMM PF02568; match to protein family HMM PF06508; match to protein family HMM TIGR00364 YP_891315.1 charges one glutamine molecule and pairs it with tRNA(Gln) YP_891316.1 identified by match to protein family HMM PF02325 YP_891317.1 identified by match to protein family HMM PF01464 YP_891320.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_891321.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_891322.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_891323.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_891324.1 identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001 YP_891325.1 identified by match to protein family HMM PF01547 YP_891326.1 identified by match to protein family HMM PF00528 YP_891327.1 identified by match to protein family HMM PF02321; match to protein family HMM TIGR01845 YP_891328.1 identified by match to protein family HMM PF00873; match to protein family HMM TIGR00915 YP_891329.1 identified by match to protein family HMM PF00529; match to protein family HMM TIGR01730 YP_891330.1 identified by match to protein family HMM PF00440 YP_891331.1 identified by match to protein family HMM PF00037; match to protein family HMM TIGR02745 YP_891332.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_891335.1 identified by match to protein family HMM PF01058 YP_891336.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate YP_891337.1 identified by match to protein family HMM PF00329; match to protein family HMM PF00346 YP_891338.1 identified by match to protein family HMM PF00361 YP_891340.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide YP_891341.1 identified by match to protein family HMM PF00146 YP_891342.1 identified by match to protein family HMM PF00361 YP_891343.1 identified by match to protein family HMM PF00037 YP_891344.1 identified by match to protein family HMM PF00221 YP_891346.1 identified by match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM TIGR01409; match to protein family HMM TIGR01813 YP_891348.1 identified by match to protein family HMM PF03264 YP_891349.1 identified by match to protein family HMM PF02518; match to protein family HMM PF02743 YP_891350.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_891351.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_891354.1 identified by match to protein family HMM PF04214 YP_891355.1 identified by match to protein family HMM PF03605; match to protein family HMM TIGR00770 YP_891356.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope YP_891357.1 identified by match to protein family HMM PF01435 YP_891358.1 identified by match to protein family HMM PF02652; match to protein family HMM TIGR00795 YP_891359.1 identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471 YP_891362.1 identified by match to protein family HMM PF00507 YP_891363.1 identified by match to protein family HMM PF01058; match to protein family HMM TIGR01957 YP_891364.1 identified by match to protein family HMM PF00329; match to protein family HMM PF00346 YP_891365.1 identified by match to protein family HMM PF01257 YP_891366.1 identified by match to protein family HMM PF01512 YP_891367.1 identified by match to protein family HMM PF00111 YP_891368.1 identified by match to protein family HMM PF00146 YP_891369.1 identified by match to protein family HMM PF00037 YP_891370.1 identified by match to protein family HMM PF00499 YP_891371.1 identified by match to protein family HMM PF00420 YP_891372.1 identified by match to protein family HMM PF00361; match to protein family HMM PF00662; match to protein family HMM TIGR01974 YP_891373.1 identified by match to protein family HMM PF00361; match to protein family HMM TIGR01972 YP_891374.1 identified by match to protein family HMM PF00361 YP_891376.1 catalyzes the ATP-dependent transport of cobalt YP_891378.1 identified by match to protein family HMM PF02361 YP_891379.1 identified by match to protein family HMM PF00005; match to protein family HMM PF02463 YP_891380.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_891381.1 catalyzes the formation of biotin from dethiobiotin and sulfur YP_891382.1 identified by match to protein family HMM PF00999 YP_891383.1 identified by match to protein family HMM PF00285; match to protein family HMM TIGR01798 YP_891384.1 identified by match to protein family HMM PF00459 YP_891385.1 identified by match to protein family HMM PF01547; match to protein family HMM TIGR00975 YP_891386.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138 YP_891387.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974 YP_891388.1 identified by match to protein family HMM PF00005; match to protein family HMM TIGR00972 YP_891389.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690 YP_891390.1 identified by match to protein family HMM PF00015 YP_891392.1 identified by match to protein family HMM PF00583 YP_891394.1 identified by match to protein family HMM PF00994; match to protein family HMM PF03453; match to protein family HMM PF03454; match to protein family HMM TIGR00177 YP_891395.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02743 YP_891398.1 identified by match to protein family HMM PF02597 YP_891399.1 identified by match to protein family HMM PF05670 YP_891400.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis YP_891402.1 identified by match to protein family HMM PF02253 YP_891405.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_891406.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_891407.1 identified by match to protein family HMM PF02642 YP_891408.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_891409.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_891413.1 identified by match to protein family HMM PF01148 YP_891414.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_891415.1 identified by match to protein family HMM PF03352 YP_891416.1 identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801 YP_891417.1 identified by match to protein family HMM PF02557; match to protein family HMM TIGR01409 YP_891419.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_891421.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_891422.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin YP_891425.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_891426.1 identified by match to protein family HMM PF04055 YP_891427.1 identified by match to protein family HMM PF00465 YP_891431.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_891433.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_891434.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_891435.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_891436.1 identified by match to protein family HMM PF00037 YP_891437.1 identified by match to protein family HMM PF00334 YP_891439.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_891440.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_891441.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_891444.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_891446.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_891447.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518 YP_891448.1 identified by match to protein family HMM PF00037 YP_891449.1 identified by match to protein family HMM PF02541 YP_891451.1 identified by match to protein family HMM PF01207 YP_891453.1 identified by match to protein family HMM PF01258 YP_891454.1 similar to jhp_0883; identified by match to protein family HMM PF02590 YP_891455.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_891456.1 identified by match to protein family HMM PF00578 YP_891458.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_891459.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_891460.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_891462.1 identified by match to protein family HMM PF07158 YP_891464.1 identified by match to protein family HMM PF00005 YP_891465.1 identified by match to protein family HMM PF01061 YP_891466.1 identified by match to protein family HMM PF01061 YP_891467.1 identified by match to protein family HMM PF01475 YP_891468.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_891469.1 binds to and inhibits the function of flagella specific ATPase FliI YP_891470.1 One of three proteins involved in switching the direction of the flagellar rotation YP_891471.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_891472.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_891473.1 identified by match to protein family HMM PF00800; match to protein family HMM PF01817; match to protein family HMM PF01842; match to protein family HMM TIGR01807 YP_891474.1 identified by match to protein family HMM TIGR01460 YP_891475.1 identified by match to protein family HMM PF00278; match to protein family HMM PF02784; match to protein family HMM TIGR01048 YP_891476.1 identified by match to protein family HMM PF03739 YP_891478.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_891479.1 identified by match to protein family HMM PF00296 YP_891480.1 identified by match to protein family HMM PF01497 YP_891481.1 identified by match to protein family HMM PF00950; match to protein family HMM PF01032 YP_891482.1 identified by match to protein family HMM PF00005 YP_891484.1 identified by match to protein family HMM PF01618; match to protein family HMM TIGR02805 YP_891485.1 identified by match to protein family HMM PF02472; match to protein family HMM TIGR02804 YP_891486.1 identified by match to protein family HMM TIGR01352 YP_891487.1 identified by match to protein family HMM PF03435 YP_891489.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_891490.1 identified by match to protein family HMM PF00590; match to protein family HMM TIGR00096 YP_891491.1 identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186 YP_891494.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_891495.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_891496.1 similar to jhp_0762; identified by match to protein family HMM PF02021 YP_891497.1 identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068 YP_891498.1 identified by match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01292 YP_891500.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_891501.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_891504.1 identified by match to protein family HMM PF01502; match to protein family HMM PF01503 YP_891505.1 identified by match to protein family HMM PF01145 YP_891506.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_891507.1 identified by match to protein family HMM PF01381 YP_891512.1 identified by match to protein family HMM PF01361 YP_891513.1 identified by match to protein family HMM PF00578 YP_891514.1 identified by match to protein family HMM PF05359 YP_891515.1 identified by match to protein family HMM PF02677 YP_891516.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_891517.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_891518.1 binds and unfolds substrates as part of the ClpXP protease YP_891519.1 functions in MreBCD complex in some organisms YP_891520.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_891521.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_891522.1 identified by match to protein family HMM PF01729 YP_891524.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00989; match to protein family HMM TIGR00229 YP_891526.1 identified by match to protein family HMM PF00899 YP_891527.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_891528.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_891529.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_891530.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_891532.1 identified by match to protein family HMM PF00072; match to protein family HMM PF01584 YP_891533.1 identified by match to protein family HMM PF00072; match to protein family HMM PF01584; match to protein family HMM PF01627; match to protein family HMM PF02518; match to protein family HMM PF02895 YP_891534.1 identified by match to protein family HMM PF01584 YP_891535.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488 YP_891536.1 Important for the balance of metabolites in the pentose-phosphate pathway YP_891537.1 identified by match to protein family HMM PF00437; match to protein family HMM TIGR01420 YP_891538.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_891539.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_891540.1 identified by match to protein family HMM PF00278; match to protein family HMM TIGR01047 YP_891541.1 identified by match to protein family HMM PF01206 YP_891542.1 identified by match to protein family HMM PF02769; match to protein family HMM TIGR00476 YP_891543.1 identified by match to protein family HMM PF00881 YP_891544.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_891545.1 identified by match to protein family HMM PF00999; match to protein family HMM PF06965; match to protein family HMM TIGR00773 YP_891546.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_891548.1 identified by match to protein family HMM PF00939; match to protein family HMM TIGR00785 YP_891549.1 identified by match to protein family HMM PF01925 YP_891550.1 identified by match to protein family HMM PF01925 YP_891551.1 identified by match to protein family HMM PF03625 YP_891552.1 identified by match to protein family HMM PF00425 YP_891553.1 identified by match to protein family HMM PF00117; match to protein family HMM PF00591; match to protein family HMM TIGR00566; match to protein family HMM TIGR01245 YP_891554.1 identified by match to protein family HMM PF00697 YP_891555.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_891556.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_891558.1 One of three proteins involved in switching the direction of the flagellar rotation YP_891561.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR02141 YP_891562.1 identified by match to protein family HMM PF00005 YP_891564.1 identified by match to protein family HMM PF01547; match to protein family HMM TIGR01256 YP_891565.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03459; match to protein family HMM TIGR00638 YP_891566.1 identified by match to protein family HMM PF04333 YP_891567.1 identified by match to protein family HMM PF05494 YP_891569.1 identified by match to protein family HMM PF04972 YP_891570.1 identified by match to protein family HMM PF00563; match to protein family HMM PF00989; match to protein family HMM PF00990; match to protein family HMM TIGR00229; match to protein family HMM TIGR00254 YP_891571.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_891572.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_891575.1 identified by match to protein family HMM PF04368 YP_891576.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_891578.1 identified by match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM TIGR00229 YP_891579.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_891580.1 CcoN; FixN YP_891581.1 CcoO; FixO YP_891582.1 identified by match to protein family HMM TIGR02736 YP_891583.1 identified by match to protein family HMM PF00034; match to protein family HMM TIGR00782 YP_891588.1 identified by match to protein family HMM PF00580 YP_891589.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_891590.1 forms a direct contact with the tRNA during translation YP_891591.1 identified by match to protein family HMM PF00691 YP_891592.1 identified by match to protein family HMM PF00924 YP_891593.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549 YP_891594.1 identified by match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176 YP_891598.1 identified by match to protein family HMM PF05538 YP_891599.1 identified by match to protein family HMM PF05538 YP_891600.1 identified by match to protein family HMM PF00034 YP_891601.1 identified by match to protein family HMM PF01094 YP_891602.1 identified by match to protein family HMM PF02653 YP_891603.1 identified by match to protein family HMM PF02653 YP_891604.1 identified by match to protein family HMM PF00005 YP_891605.1 identified by match to protein family HMM PF00005 YP_891606.1 identified by match to protein family HMM PF01578 YP_891608.1 identified by match to protein family HMM PF04608 YP_891610.1 identified by match to protein family HMM PF00072 YP_891611.1 bifunctional enzyme involved in formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate and 2-C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP from 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; binds divalent cations YP_891612.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_891615.1 identified by match to protein family HMM PF00005; match to protein family HMM PF02463 YP_891616.1 part of three member fumarate reductase enzyme complex FrdABC which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdC is the cytochrome b-556 subunit; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_891617.1 part of three member fumarate reductase enzyme complex FrdABC which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdC is the cytochrome b-556 subunit; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_891618.1 part of three member fumarate reductase enzyme complex FrdABC which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdC is the cytochrome b-556 subunit YP_891619.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_891621.1 identified by match to protein family HMM PF00817 YP_891623.1 identified by match to protein family HMM PF00583 YP_891624.1 identified by match to protein family HMM PF03222 YP_891625.1 identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033 YP_891626.1 identified by match to protein family HMM PF00160 YP_891627.1 identified by match to protein family HMM PF00375 YP_891628.1 identified by match to protein family HMM PF00375 YP_891629.1 identified by match to protein family HMM PF00027; match to protein family HMM PF00325 YP_891630.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR01409 YP_891631.1 identified by match to protein family HMM PF00512; match to protein family HMM PF02518 YP_891632.1 identified by match to protein family HMM PF00072 YP_891635.1 identified by match to protein family HMM PF00593 YP_891636.1 identified by match to protein family HMM PF05935 YP_891637.1 identified by match to protein family HMM PF00350 YP_891638.1 identified by match to protein family HMM PF00350 YP_891640.1 identified by match to protein family HMM PF00116 YP_891643.1 identified by match to protein family HMM PF00037 YP_891646.1 identified by match to protein family HMM PF00037; match to protein family HMM TIGR02163 YP_891647.1 identified by match to protein family HMM PF00005 YP_891650.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672 YP_891651.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_891652.1 identified by match to protein family HMM PF01292 YP_891656.1 identified by match to protein family HMM PF02321 YP_891657.1 identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843 YP_891658.1 identified by match to protein family HMM PF00005; match to protein family HMM TIGR01842 YP_891659.1 identified by match to protein family HMM PF07277 YP_891665.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_891667.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_891668.1 identified by match to protein family HMM PF01594 YP_891669.1 identified by match to protein family HMM PF00005 YP_891670.1 identified by match to protein family HMM PF02470 YP_891672.1 identified by match to protein family HMM PF02130; match to protein family HMM TIGR00043 YP_891674.1 identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385 YP_891677.1 identified by match to protein family HMM PF07804; match to protein family HMM PF07805; match to protein family HMM TIGR03071 YP_891680.1 identified by match to protein family HMM PF01637; match to protein family HMM PF03008 YP_891685.1 identified by match to protein family HMM PF00534 YP_891686.1 identified by match to protein family HMM PF00534 YP_891688.1 identified by match to protein family HMM PF00005 YP_891689.1 identified by match to protein family HMM PF01061 YP_891690.1 identified by match to protein family HMM PF00534 YP_891691.1 identified by match to protein family HMM PF02397; match to protein family HMM TIGR03025 YP_891692.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_891693.1 identified by match to protein family HMM PF00448; match to protein family HMM TIGR00064 YP_891695.1 identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727 YP_891696.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP YP_891700.1 identified by match to protein family HMM PF00633 YP_891701.1 identified by match to protein family HMM PF00015 YP_891702.1 identified by match to protein family HMM PF00202; match to protein family HMM TIGR00508 YP_891703.1 identified by match to protein family HMM PF00730; match to protein family HMM TIGR01083 YP_891704.1 identified by match to protein family HMM PF00639 YP_891705.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_891709.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_891710.1 identified by match to protein family HMM PF00669 YP_891711.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_891712.1 identified by match to protein family HMM PF00460 YP_891713.1 makes up the distal portion of the flagellar basal body rod YP_891714.1 identified by match to protein family HMM PF03239 YP_891716.1 identified by match to protein family HMM PF04945 YP_891717.1 identified by match to protein family HMM PF02687 YP_891718.1 identified by match to protein family HMM PF02687 YP_891719.1 identified by match to protein family HMM PF00005 YP_891721.1 identified by match to protein family HMM PF04371 YP_891722.1 identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297 YP_891723.1 identified by match to protein family HMM PF00795 YP_891724.1 identified by match to protein family HMM PF03616; match to protein family HMM TIGR00210 YP_891725.1 identified by match to protein family HMM PF01863 YP_891726.1 identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797 YP_891727.1 identified by match to protein family HMM PF00512; match to protein family HMM PF02518 YP_891728.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_891729.1 identified by match to protein family HMM PF00083; match to protein family HMM PF07690 YP_891730.1 identified by match to protein family HMM PF00005; match to protein family HMM PF02463 YP_891731.1 identified by match to protein family HMM PF00209 YP_891732.1 identified by match to protein family HMM PF01435 YP_891733.1 identified by match to protein family HMM PF05175; match to protein family HMM TIGR00536 YP_891738.1 identified by match to protein family HMM PF00583 YP_891739.1 identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836 YP_891740.1 identified by match to protein family HMM PF00543 YP_891741.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_891742.1 identified by match to protein family HMM PF00825; match to protein family HMM TIGR00188 YP_891743.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_891745.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_891746.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_891747.1 identified by match to protein family HMM PF00226 YP_891748.1 involved in de novo purine biosynthesis YP_891751.1 identified by match to protein family HMM PF01883 YP_891752.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672 YP_891753.1 identified by match to protein family HMM PF01063 YP_891757.1 identified by match to protein family HMM PF01795; match to protein family HMM TIGR00006 YP_891758.1 identified by match to protein family HMM PF00596 YP_891760.1 identified by match to protein family HMM PF02491; match to protein family HMM TIGR01174 YP_891761.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_891762.1 identified by match to protein family HMM PF00877 YP_891765.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_891766.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_891767.1 identified by match to protein family HMM PF02687 YP_891770.1 identified by match to protein family HMM PF07690 YP_891771.1 identified by match to protein family HMM PF00156 YP_891772.1 identified by match to protein family HMM PF00860; match to protein family HMM PF00916 YP_891773.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR00423 YP_891774.1 identified by match to protein family HMM PF01966 YP_891775.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_891776.1 identified by match to protein family HMM PF04143 YP_891777.1 identified by match to protein family HMM PF01206 YP_891779.1 identified by match to protein family HMM PF01177; match to protein family HMM TIGR00067 YP_891780.1 identified by match to protein family HMM PF01977; match to protein family HMM TIGR00148 YP_891781.1 identified by match to protein family HMM PF00633 YP_891782.1 identified by match to protein family HMM PF00990; match to protein family HMM PF01814; match to protein family HMM TIGR00254; match to protein family HMM TIGR02481 YP_891784.1 identified by match to protein family HMM PF02464; match to protein family HMM TIGR00199 YP_891786.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_891787.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_891788.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_891789.1 identified by match to protein family HMM PF00561; match to protein family HMM TIGR01392 YP_891792.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_891794.1 identified by match to protein family HMM PF00724 YP_891795.1 identified by match to protein family HMM PF00005 YP_891796.1 identified by match to protein family HMM PF00528 YP_891797.1 identified by match to protein family HMM PF03180 YP_891799.1 identified by match to protein family HMM PF02566 YP_891800.1 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange YP_891801.1 identified by match to protein family HMM PF00563; match to protein family HMM PF00990 YP_891802.1 identified by match to protein family HMM PF01810 YP_891803.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_891804.1 identified by match to protein family HMM PF01266; match to protein family HMM PF06039 YP_891806.1 identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064 YP_891807.1 identified by match to protein family HMM PF00675; match to protein family HMM PF05193 YP_891808.1 catalyzes branch migration in Holliday junction intermediates YP_891809.1 identified by match to protein family HMM PF01474; match to protein family HMM TIGR01358 YP_891810.1 identified by match to protein family HMM TIGR00407 YP_891811.1 identified by match to protein family HMM PF00070; match to protein family HMM PF07992 YP_891813.1 identified by match to protein family HMM PF05175 YP_891814.1 identified by match to protein family HMM PF03692 YP_891816.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_891817.1 identified by match to protein family HMM PF01230 YP_891818.1 identified by match to protein family HMM PF03883 YP_891824.1 identified by match to protein family HMM PF03237 YP_891825.1 identified by match to protein family HMM PF04860 YP_891834.1 identified by match to protein family HMM TIGR01877 YP_891837.1 identified by match to protein family HMM TIGR02592; match to protein family HMM TIGR02593 YP_891838.1 identified by match to protein family HMM PF00271; match to protein family HMM TIGR01587 YP_891839.1 identified by match to protein family HMM PF01930 YP_891840.1 identified by match to protein family HMM PF01867; match to protein family HMM TIGR00287 YP_891841.1 identified by match to protein family HMM TIGR01573 YP_891851.1 biotin carboxylase; catalyses the carboxylation of the carrier protein which then transfers the carboxyl group to form malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_891853.1 Conjugates Arg from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate YP_891854.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_891855.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_891856.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_891857.1 identified by match to protein family HMM PF01384 YP_891858.1 identified by match to protein family HMM PF00669 YP_891859.1 identified by match to protein family HMM PF01580 YP_891862.1 identified by match to protein family HMM PF00348 YP_891863.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_891864.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_891866.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_891867.1 identified by match to protein family HMM PF03631; match to protein family HMM TIGR00765 YP_891868.1 identified by match to protein family HMM PF01565; match to protein family HMM PF02913 YP_891871.1 identified by match to protein family HMM PF01551 YP_891872.1 identified by match to protein family HMM PF00571; match to protein family HMM PF01769; match to protein family HMM PF03448; match to protein family HMM TIGR00400 YP_891873.1 identified by match to protein family HMM PF00293; match to protein family HMM TIGR00052 YP_891875.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_891876.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_891877.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_891878.1 identified by match to protein family HMM PF00905; match to protein family HMM PF03717 YP_891879.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_891880.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_891881.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_891882.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_891884.1 identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728 YP_891885.1 identified by match to protein family HMM PF02617 YP_891887.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_891888.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis YP_891889.1 identified by match to protein family HMM PF02599; match to protein family HMM TIGR00202 YP_891890.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_891891.1 identified by match to protein family HMM PF00580 YP_891892.1 identified by match to protein family HMM PF00126 YP_891894.1 identified by match to protein family HMM PF01432 YP_891895.1 involved in the import of serine and threonine coupled with the import of sodium YP_891896.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_891897.1 identified by match to protein family HMM PF01297 YP_891898.1 identified by match to protein family HMM PF00005 YP_891899.1 identified by match to protein family HMM PF00950 YP_891900.1 identified by match to protein family HMM PF00950 YP_891901.1 Transfers the fatty acyl group on membrane lipoproteins YP_891902.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_891903.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_891904.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_891906.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_891908.1 identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254 YP_891909.1 identified by match to protein family HMM TIGR01499 YP_891910.1 identified by match to protein family HMM PF01551 YP_891911.1 identified by match to protein family HMM PF04519 YP_891912.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580 YP_891915.1 identified by match to protein family HMM PF00730 YP_891916.1 identified by match to protein family HMM PF04076 YP_891917.1 identified by match to protein family HMM PF02629 YP_891918.1 catalyzes the formation of 2-oxobutanoate from L-threonine YP_891919.1 identified by match to protein family HMM PF05594; match to protein family HMM PF05860; match to protein family HMM TIGR01901 YP_891920.1 identified by match to protein family HMM PF03865 YP_891922.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_891923.1 identified by match to protein family HMM PF03739 YP_891924.1 identified by match to protein family HMM PF06750 YP_891925.1 identified by match to protein family HMM PF01255; match to protein family HMM TIGR00055 YP_891927.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_891928.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_891929.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_891931.1 identified by match to protein family HMM PF03547 YP_891932.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_891933.1 identified by match to protein family HMM PF00529; match to protein family HMM TIGR01730 YP_891934.1 identified by match to protein family HMM PF00005; match to protein family HMM PF02687 YP_891935.1 identified by match to protein family HMM PF02321 YP_891936.1 identified by match to protein family HMM PF03772; match to protein family HMM TIGR00360 YP_891937.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672 YP_891938.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_891939.1 identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037 YP_891940.1 identified by match to protein family HMM PF00226; match to protein family HMM PF01556 YP_891941.1 identified by match to protein family HMM PF00376 YP_891942.1 identified by match to protein family HMM PF00999; match to protein family HMM PF02254 YP_891943.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_891945.1 identified by match to protein family HMM PF01925 YP_891946.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_891948.1 identified by match to protein family HMM PF02581 YP_891949.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_891950.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_891951.1 identified by match to protein family HMM PF00933 YP_891953.1 identified by match to protein family HMM PF00892; match to protein family HMM TIGR00688 YP_891954.1 identified by match to protein family HMM PF00005 YP_891955.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_891956.1 identified by match to protein family HMM PF00497 YP_891957.1 identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560 YP_891958.1 Acts on the hydroxyl group at position 7 of the steroid frame YP_891959.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_891960.1 identified by match to protein family HMM PF00675; match to protein family HMM PF05193 YP_891961.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_891962.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664 YP_891963.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_891964.1 identified by match to protein family HMM PF03023; match to protein family HMM TIGR01695 YP_891966.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04851 YP_891968.1 identified by match to protein family HMM PF03205; match to protein family HMM TIGR00176 YP_891969.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_891971.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_891973.1 identified by match to protein family HMM PF00027; match to protein family HMM PF00325 YP_891974.1 identified by match to protein family HMM PF03264 YP_891976.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR00423 YP_891978.1 identified by match to protein family HMM PF04332; match to protein family HMM PF07690 YP_891979.1 identified by match to protein family HMM PF01739 YP_891980.1 identified by match to protein family HMM PF01339 YP_891982.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_891983.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_891987.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_891988.1 identified by match to protein family HMM PF01515; match to protein family HMM TIGR00651 YP_891989.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_891990.1 identified by match to protein family HMM PF03713 YP_891991.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine resistant; also known as acetolactate synthase 3 large subunit YP_891992.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_891993.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_891996.1 identified by match to protein family HMM PF01729; match to protein family HMM PF02749; match to protein family HMM TIGR00078 YP_891997.1 identified by match to protein family HMM PF00551; match to protein family HMM TIGR00655 YP_891998.1 identified by match to protein family HMM PF00588 YP_891999.1 identified by match to protein family HMM PF03372 YP_892001.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_892002.1 identified by match to protein family HMM PF02086 YP_892005.1 identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835 YP_892006.1 identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01525 YP_892013.1 identified by match to protein family HMM PF01551 YP_892015.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_892016.1 identified by match to protein family HMM PF00512; match to protein family HMM PF02518 YP_892017.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_892018.1 identified by match to protein family HMM PF00589 YP_892019.1 identified by match to protein family HMM PF01098 YP_892020.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_892021.1 identified by match to protein family HMM PF00216 YP_892022.1 identified by match to protein family HMM PF01618; match to protein family HMM TIGR02805 YP_892023.1 identified by match to protein family HMM PF02472; match to protein family HMM TIGR02804 YP_892024.1 identified by match to protein family HMM PF03544; match to protein family HMM TIGR01352 YP_892025.1 identified by match to protein family HMM PF01479 YP_892026.1 identified by match to protein family HMM PF02367; match to protein family HMM TIGR00150 YP_892027.1 identified by match to protein family HMM PF00005 YP_892028.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_892029.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_892030.1 identified by match to protein family HMM PF00924 YP_892031.1 identified by match to protein family HMM PF00919; match to protein family HMM PF04055; match to protein family HMM TIGR00089; match to protein family HMM TIGR01579 YP_892032.1 identified by match to protein family HMM PF00004; match to protein family HMM PF01434; match to protein family HMM PF06480 YP_892033.1 identified by match to protein family HMM PF00994; match to protein family HMM TIGR00177 YP_892034.1 identified by match to protein family HMM PF01168; match to protein family HMM TIGR00044 YP_892035.1 identified by match to protein family HMM PF02163; match to protein family HMM TIGR00054 YP_892036.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_892037.1 3'-5' exonuclease of DNA polymerase III YP_892038.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_892039.1 identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532 YP_892040.1 identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532 YP_892041.1 identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532 YP_892046.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_892047.1 identified by match to protein family HMM PF03929 YP_892048.1 identified by match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783 YP_892049.1 identified by match to protein family HMM PF01554 YP_892050.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_892052.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_892054.1 identified by match to protein family HMM PF00300 YP_892055.1 identified by match to protein family HMM PF04305 YP_892056.1 identified by match to protein family HMM PF01694 YP_892057.1 identified by match to protein family HMM PF02754 YP_892058.1 identified by match to protein family HMM PF00037; match to protein family HMM TIGR00273 YP_892059.1 identified by match to protein family HMM PF02589 YP_892061.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_892062.1 identified by match to protein family HMM PF00994; match to protein family HMM PF03453; match to protein family HMM TIGR00177 YP_892063.1 required for the assembly of the flagellar basal body P-ring YP_892064.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_892065.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_892066.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_892067.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis YP_892068.1 identified by match to protein family HMM PF00132; match to protein family HMM TIGR01172 YP_892069.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_892070.1 identified by match to protein family HMM PF00535 YP_892071.1 identified by match to protein family HMM PF05787 YP_892072.1 identified by match to protein family HMM PF00258 YP_892074.1 identified by match to protein family HMM PF03401 YP_892076.1 identified by match to protein family HMM PF01558 YP_892077.1 identified by match to protein family HMM PF02775 YP_892078.1 identified by match to protein family HMM PF01855 YP_892079.1 identified by match to protein family HMM PF00037 YP_892080.1 identified by match to protein family HMM PF00549; match to protein family HMM PF02629; match to protein family HMM TIGR01019 YP_892081.1 catalyzes the interconversion of succinyl-CoA and succinate YP_892082.1 identified by match to protein family HMM PF00056; match to protein family HMM PF00070; match to protein family HMM PF02866 YP_892083.1 identified by match to protein family HMM PF03971; match to protein family HMM TIGR00178 YP_892084.1 identified by match to protein family HMM PF03595 YP_892085.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549 YP_892087.1 identified by match to protein family HMM PF00171; match to protein family HMM TIGR01780 YP_892088.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_892089.1 identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326 YP_892090.1 identified by match to protein family HMM PF02082 YP_892091.1 identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139 YP_892092.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_892093.1 interacts with the cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring YP_892094.1 identified by match to protein family HMM PF01557 YP_892095.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_892096.1 identified by match to protein family HMM PF03458 YP_892097.1 identified by match to protein family HMM PF02618 YP_892099.1 identified by match to protein family HMM PF01155 YP_892100.1 identified by match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR02124 YP_892101.1 identified by match to protein family HMM PF01924; match to protein family HMM TIGR00075 YP_892102.1 identified by match to protein family HMM PF01455; match to protein family HMM TIGR00074 YP_892103.1 identified by match to protein family HMM PF02492; match to protein family HMM TIGR00073 YP_892104.1 Inhibits transcription at high concentrations of nickel YP_892105.1 identified by match to protein family HMM PF00708; match to protein family HMM PF01300; match to protein family HMM PF07503; match to protein family HMM TIGR00143 YP_892107.1 identified by match to protein family HMM PF01750; match to protein family HMM TIGR00072 YP_892108.1 identified by match to protein family HMM PF01292; match to protein family HMM TIGR02125 YP_892109.1 identified by match to protein family HMM PF00374 YP_892110.1 identified by match to protein family HMM PF01058; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409 YP_892111.1 identified by match to protein family HMM PF05437 YP_892112.1 identified by match to protein family HMM PF03591 YP_892113.1 identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728 YP_892114.1 identified by match to protein family HMM PF00595; match to protein family HMM PF03572; match to protein family HMM TIGR00225 YP_892115.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_892116.1 identified by match to protein family HMM PF02700; match to protein family HMM TIGR00302 YP_892117.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_892119.1 identified by match to protein family HMM PF01553; match to protein family HMM TIGR00530 YP_892120.1 identified by match to protein family HMM PF02537; match to protein family HMM TIGR00494 YP_892121.1 identified by match to protein family HMM PF03498 YP_892122.1 identified by match to protein family HMM PF03498 YP_892123.1 identified by match to protein family HMM PF03498 YP_892124.1 identified by match to protein family HMM PF03372 YP_892125.1 identified by match to protein family HMM PF03498 YP_892126.1 molecular chaperone YP_892127.1 identified by match to protein family HMM PF00581 YP_892129.1 identified by match to protein family HMM PF00580 YP_892133.1 identified by match to protein family HMM PF00206; match to protein family HMM TIGR00979 YP_892134.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_892135.1 identified by match to protein family HMM PF00005 YP_892136.1 identified by match to protein family HMM PF00528 YP_892137.1 identified by match to protein family HMM TIGR00097 YP_892138.1 identified by match to protein family HMM PF03180 YP_892139.1 required for 70S ribosome assembly YP_892140.1 identified by match to protein family HMM PF02080; match to protein family HMM PF02254; match to protein family HMM PF07885 YP_892141.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_892142.1 identified by match to protein family HMM PF04325 YP_892143.1 identified by match to protein family HMM PF00015 YP_892144.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_892145.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01370 YP_892146.1 identified by match to protein family HMM PF00023 YP_892147.1 identified by match to protein family HMM PF02080 YP_892148.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_892150.1 unwinds double stranded DNA YP_892151.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_892152.1 identified by match to protein family HMM PF01863 YP_892153.1 identified by match to protein family HMM PF04313; match to protein family HMM PF04851; match to protein family HMM TIGR00348 YP_892156.1 identified by match to protein family HMM PF01420 YP_892158.1 identified by match to protein family HMM PF02384; match to protein family HMM TIGR00497 YP_892159.1 identified by match to protein family HMM PF01420 YP_892163.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_892164.1 identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589 YP_892165.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate YP_892166.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_892167.1 heat shock protein involved in degradation of misfolded proteins YP_892168.1 heat shock protein involved in degradation of misfolded proteins YP_892169.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_892173.1 identified by match to protein family HMM PF00263; match to protein family HMM PF07655; match to protein family HMM TIGR02519 YP_892176.1 identified by match to protein family HMM PF00437; match to protein family HMM PF05157 YP_892177.1 identified by match to protein family HMM PF00482 YP_892178.1 identified by match to protein family HMM PF00989; match to protein family HMM TIGR00229 YP_892179.1 identified by match to protein family HMM PF02637 YP_892180.1 identified by match to protein family HMM PF02541 YP_892181.1 identified by match to protein family HMM PF01743 YP_892184.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_892185.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis YP_892186.1 identified by match to protein family HMM PF01810 YP_892187.1 identified by match to protein family HMM PF01810 YP_892189.1 identified by match to protein family HMM PF00710; match to protein family HMM TIGR00520 YP_892190.1 identified by match to protein family HMM PF02646 YP_892191.1 identified by match to protein family HMM PF03547 YP_892192.1 identified by match to protein family HMM PF03831 YP_892193.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_892195.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_892196.1 identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074 YP_892198.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_892199.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_892200.1 identified by match to protein family HMM PF01782; match to protein family HMM PF05239; match to protein family HMM TIGR02273 YP_892202.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_892203.1 identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959 YP_892204.1 identified by match to protein family HMM PF00939; match to protein family HMM PF03600 YP_892205.1 identified by match to protein family HMM PF00015 YP_892206.1 identified by match to protein family HMM PF00849 YP_892207.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_892209.1 identified by match to protein family HMM PF02591 YP_892210.1 identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486 YP_892211.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_892213.1 identified by match to protein family HMM PF00731; match to protein family HMM TIGR01162 YP_892214.1 identified by match to protein family HMM PF01136 YP_892216.1 identified by match to protein family HMM PF02811; match to protein family HMM TIGR01856 YP_892217.1 identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653 YP_892219.1 identified by match to protein family HMM PF00023 YP_892220.1 identified by match to protein family HMM PF00199 YP_892221.1 identified by match to protein family HMM PF00004; match to protein family HMM PF05362; match to protein family HMM PF07728; match to protein family HMM TIGR00763 YP_892223.1 identified by match to protein family HMM PF01614 YP_892224.1 identified by match to protein family HMM PF00701 YP_892225.1 identified by match to protein family HMM PF04292; match to protein family HMM PF04295 YP_892226.1 identified by match to protein family HMM PF00106 YP_892227.1 identified by match to protein family HMM PF07690; match to protein family HMM TIGR00885 YP_892228.1 identified by match to protein family HMM PF04909; match to protein family HMM PF05336 YP_892229.1 binds to flagellin and appears to stabilize flagellin during flagella assembly YP_892230.1 identified by match to protein family HMM TIGR02532 YP_892231.1 identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532 YP_892233.1 identified by match to protein family HMM PF02482; match to protein family HMM TIGR00741 YP_892234.1 identified by match to protein family HMM PF05343; match to protein family HMM PF07687 YP_892236.1 identified by match to protein family HMM PF08003 YP_892238.1 identified by match to protein family HMM PF00753 YP_892239.1 identified by match to protein family HMM PF02540; match to protein family HMM TIGR00552 YP_892240.1 identified by match to protein family HMM PF01041; match to protein family HMM PF01212 YP_892241.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_892242.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_892243.1 identified by match to protein family HMM PF00291; match to protein family HMM PF03091; match to protein family HMM TIGR00260 YP_892244.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_892246.1 identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254 YP_892247.1 identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254 YP_892248.1 identified by match to protein family HMM PF00085; match to protein family HMM PF02683 YP_892249.1 identified by match to protein family HMM PF03976 YP_892250.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_892251.1 identified by match to protein family HMM PF01025 YP_892252.1 Acts as a negative regulator of the grpE-dnaK-dnaJ and groELS class I heat shock operons by preventing heat-shock induction YP_892256.1 membrane protein involved in the flagellar export apparatus YP_892257.1 identified by match to protein family HMM PF02082; match to protein family HMM TIGR00738 YP_892258.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_892259.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine YP_892261.1 identified by match to protein family HMM TIGR01488; match to protein family HMM TIGR01490 YP_892262.1 identified by match to protein family HMM PF00005 YP_892263.1 identified by match to protein family HMM PF00528 YP_892264.1 identified by match to protein family HMM PF00528 YP_892267.1 identified by match to protein family HMM PF02390; match to protein family HMM TIGR00740 YP_892268.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_892269.1 identified by match to protein family HMM PF01479; match to protein family HMM PF01728 YP_892270.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_892271.1 identified by match to protein family HMM PF00809; match to protein family HMM TIGR01496 YP_892272.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_892274.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_892275.1 hydrolyzes diadenosine polyphosphate YP_892276.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_892277.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_892278.1 identified by match to protein family HMM PF00902; match to protein family HMM TIGR00945 YP_892279.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_892281.1 identified by match to protein family HMM PF01189 YP_892282.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_892283.1 identified by match to protein family HMM PF02481 YP_892284.1 identified by match to protein family HMM PF04748 YP_892285.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_892287.1 identified by match to protein family HMM PF00773; match to protein family HMM PF08206 YP_892288.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_892289.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_892290.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_892291.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_892292.1 identified by match to protein family HMM PF00226; match to protein family HMM PF00684; match to protein family HMM PF01556; match to protein family HMM TIGR02349 YP_892293.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_892294.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672 YP_892295.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_892296.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_892297.1 identified by match to protein family HMM PF05036 YP_892299.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_892300.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_892301.1 identified by match to protein family HMM PF01475 YP_892302.1 identified by match to protein family HMM PF02674 YP_892303.1 identified by match to protein family HMM PF00437; match to protein family HMM TIGR01420 YP_892304.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_892308.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_892309.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_892310.1 identified by match to protein family HMM PF05525; match to protein family HMM TIGR00796 YP_892311.1 identified by match to protein family HMM PF00149 YP_892312.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine YP_892315.1 identified by match to protein family HMM PF00037 YP_892316.1 identified by match to protein family HMM PF03892 YP_892317.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA YP_892318.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway YP_892319.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_892320.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_892321.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_892322.1 PEB1 YP_892323.1 identified by match to protein family HMM PF00005 YP_892324.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_892325.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_892327.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_892329.1 identified by match to protein family HMM PF02502; match to protein family HMM TIGR00689; match to protein family HMM TIGR01120 YP_892330.1 identified by match to protein family HMM PF02163 YP_892331.1 identified by match to protein family HMM PF00717; match to protein family HMM TIGR02227 YP_892332.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_892334.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_892337.1 identified by match to protein family HMM PF07690 YP_892339.1 identified by match to protein family HMM TIGR00789 YP_892340.1 identified by match to protein family HMM PF00905; match to protein family HMM PF03717 YP_892342.1 catalyzes the formation of N-acetyl-L-glutamate from acetyl-CoA and L-glutamate YP_892343.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_892344.1 identified by match to protein family HMM PF03968 YP_892346.1 identified by match to protein family HMM TIGR01670 YP_892347.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_892348.1 identified by match to protein family HMM PF03330; match to protein family HMM PF05036; match to protein family HMM TIGR00413 YP_892349.1 identified by match to protein family HMM PF01464; match to protein family HMM PF01476 YP_892350.1 identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010 YP_892351.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00990; match to protein family HMM TIGR00254 YP_892352.1 identified by match to protein family HMM PF02463 YP_892353.1 catalyzes the phosphorylation of NAD to NADP YP_892354.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_892355.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_892356.1 identified by match to protein family HMM PF00719 YP_892359.1 identified by match to protein family HMM PF00005 YP_892360.1 identified by match to protein family HMM PF01032 YP_892361.1 identified by match to protein family HMM PF01497 YP_892364.1 identified by match to protein family HMM PF00593; match to protein family HMM PF07715 YP_892365.1 identified by match to protein family HMM PF00165 YP_892366.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_892367.1 identified by match to protein family HMM PF01520 YP_892368.1 identified by match to protein family HMM PF03060 YP_892369.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_892370.1 identified by match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691 YP_892371.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_892372.1 Catalyzes the phosphorylation of UMP to UDP YP_892373.1 identified by match to protein family HMM PF01551 YP_892375.1 identified by match to protein family HMM PF00005 YP_892376.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_892377.1 identified by match to protein family HMM PF00041 YP_892378.1 identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00005 YP_892379.1 identified by match to protein family HMM PF01098 YP_892380.1 identified by match to protein family HMM PF02630 YP_892381.1 identified by match to protein family HMM PF00015 YP_892382.1 identified by match to protein family HMM PF01638 YP_892384.1 identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297 YP_892385.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672 YP_892386.1 identified by match to protein family HMM PF00474; match to protein family HMM TIGR00813; match to protein family HMM TIGR02121 YP_892387.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_892388.1 identified by match to protein family HMM PF00005 YP_892389.1 identified by match to protein family HMM PF00497 YP_892390.1 identified by match to protein family HMM PF00497 YP_892391.1 identified by match to protein family HMM PF02581 YP_892392.1 identified by match to protein family HMM PF02673; match to protein family HMM TIGR00753 YP_892393.1 identified by match to protein family HMM PF00266 YP_892394.1 identified by match to protein family HMM PF03008 YP_892395.1 identified by match to protein family HMM PF00512; match to protein family HMM PF02518 YP_892396.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_892397.1 identified by match to protein family HMM PF00076 YP_892398.1 identified by match to protein family HMM PF00171; match to protein family HMM PF01619 YP_892399.1 identified by match to protein family HMM PF00474; match to protein family HMM TIGR00813; match to protein family HMM TIGR02121 YP_892401.1 identified by match to protein family HMM PF02335 YP_892402.1 identified by match to protein family HMM PF01965; match to protein family HMM TIGR01383 YP_892403.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_892404.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_892406.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_892407.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_892408.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_892409.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_892410.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_892411.1 identified by match to protein family HMM PF01230 YP_892413.1 identified by match to protein family HMM PF00013; match to protein family HMM PF00575; match to protein family HMM PF01138; match to protein family HMM PF03725; match to protein family HMM PF03726 YP_892415.1 identified by match to protein family HMM PF04453 YP_892416.1 identified by match to protein family HMM PF06271 YP_892417.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_892418.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis YP_892420.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_892422.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_892424.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518 YP_892425.1 identified by match to protein family HMM PF00072 YP_892430.1 identified by match to protein family HMM PF02690 YP_892432.1 identified by match to protein family HMM PF04341 YP_892433.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake YP_892434.1 identified by match to protein family HMM PF03061 YP_892435.1 identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401 YP_892437.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_892438.1 similar to P. aerophilum YP_892439.1 identified by match to protein family HMM PF00165; match to protein family HMM PF06719 YP_892440.1 identified by match to protein family HMM PF00465 YP_892442.1 identified by match to protein family HMM PF00165 YP_892447.1 identified by match to protein family HMM PF00209 YP_892448.1 identified by match to protein family HMM PF00364; match to protein family HMM PF00682 YP_892449.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_892450.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_892451.1 identified by match to protein family HMM PF04023 YP_892453.1 identified by match to protein family HMM PF02525 YP_892457.1 identified by match to protein family HMM PF00394; match to protein family HMM PF07731; match to protein family HMM PF07732 YP_892458.1 identified by match to protein family HMM PF00015; match to protein family HMM PF02743 YP_892460.1 identified by match to protein family HMM PF00015; match to protein family HMM PF00672; match to protein family HMM PF02743 YP_892463.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_892464.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_892465.2 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_892467.1 identified by match to protein family HMM PF00623; match to protein family HMM PF04983; match to protein family HMM PF04997; match to protein family HMM PF04998; match to protein family HMM PF05000; match to protein family HMM TIGR02386 YP_892468.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_892469.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_892470.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_892471.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_892472.1 binds directly to 23S ribosomal RNA YP_892473.1 Modulates Rho-dependent transcription termination YP_892474.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_892475.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_892476.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_892477.1 identified by match to protein family HMM PF00080 YP_892478.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_892479.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_892480.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_892481.1 identified by match to protein family HMM PF00893 YP_892482.1 identified by match to protein family HMM PF00893 YP_892483.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_892484.1 identified by match to protein family HMM PF00892 YP_892485.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_892486.1 identified by match to protein family HMM PF01202 YP_892487.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_892488.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_892489.1 identified by match to protein family HMM PF00515; match to protein family HMM PF07719 YP_892490.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_892491.1 identified by match to protein family HMM PF01066; match to protein family HMM TIGR00473 YP_892492.1 identified by match to protein family HMM PF02666 YP_892493.1 identified by match to protein family HMM PF00004; match to protein family HMM PF01434; match to protein family HMM PF06480; match to protein family HMM PF07728; match to protein family HMM TIGR01241 YP_892494.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_892495.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_892496.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_892498.1 identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321 YP_892499.1 identified by match to protein family HMM PF01041; match to protein family HMM PF01212 YP_892500.1 identified by match to protein family HMM PF02525 YP_892501.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_892502.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_892503.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_892504.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_892505.1 carries the fatty acid chain in fatty acid biosynthesis YP_892506.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_892507.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_892510.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_892511.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_892512.1 identified by match to protein family HMM PF00919; match to protein family HMM PF04055; match to protein family HMM TIGR00089; match to protein family HMM TIGR01125 YP_892513.1 identified by match to protein family HMM PF01171; match to protein family HMM TIGR02432 YP_892517.1 identified by match to protein family HMM PF04028 YP_892518.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_892520.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_892521.1 identified by match to protein family HMM PF00132 YP_892522.1 identified by match to protein family HMM PF02397 YP_892523.1 identified by match to protein family HMM PF00534 YP_892524.1 identified by match to protein family HMM PF02516 YP_892525.1 identified by match to protein family HMM PF00534 YP_892526.1 identified by match to protein family HMM PF00534 YP_892527.1 identified by match to protein family HMM PF00534 YP_892528.1 identified by match to protein family HMM PF01943 YP_892529.1 identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026 YP_892530.1 identified by match to protein family HMM PF00535 YP_892532.1 identified by match to protein family HMM PF04138 YP_892533.1 identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01179 YP_892534.1 identified by match to protein family HMM PF01420; match to protein family HMM PF02384 YP_892536.1 catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA YP_892537.1 identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF07993 YP_892538.1 identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026 YP_892540.1 identified by match to protein family HMM PF01075; match to protein family HMM TIGR02193 YP_892541.1 acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; essential for survival; plays a role in cell responses to environmental changes YP_892542.1 identified by match to protein family HMM PF00535 YP_892543.1 identified by match to protein family HMM PF01075 YP_892544.1 identified by match to protein family HMM PF01522 YP_892545.1 identified by match to protein family HMM PF00534 YP_892548.1 identified by match to protein family HMM PF00534 YP_892549.1 identified by match to protein family HMM PF01075; match to protein family HMM TIGR02195 YP_892550.1 identified by match to protein family HMM PF01380; match to protein family HMM TIGR00441 YP_892551.1 identified by match to protein family HMM PF01177; match to protein family HMM TIGR00035 YP_892552.1 identified by match to protein family HMM PF00294; match to protein family HMM PF01467; match to protein family HMM TIGR00125; match to protein family HMM TIGR02198; match to protein family HMM TIGR02199 YP_892553.1 identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR02197 YP_892554.1 identified by match to protein family HMM TIGR00213; match to protein family HMM TIGR01656; match to protein family HMM TIGR01662 YP_892555.1 identified by match to protein family HMM PF00034 YP_892556.1 identified by match to protein family HMM PF00082; match to protein family HMM PF03797; match to protein family HMM TIGR01414; match to protein family HMM TIGR02601 YP_892557.1 identified by match to protein family HMM PF00034 YP_892558.1 identified by match to protein family HMM PF03597; match to protein family HMM TIGR00847 YP_892559.1 identified by match to protein family HMM PF00122; match to protein family HMM PF00403; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525 YP_892560.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_892561.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_892565.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_892566.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_892567.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_892568.1 identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534 YP_892569.1 identified by match to protein family HMM PF01467; match to protein family HMM TIGR00482 YP_892570.1 identified by match to protein family HMM PF02410; match to protein family HMM TIGR00090 YP_892571.1 identified by match to protein family HMM PF03601; match to protein family HMM TIGR00698 YP_892572.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_892573.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_892574.1 identified by match to protein family HMM PF02416; match to protein family HMM TIGR01411 YP_892575.1 Essential for recycling GMP and indirectly, cGMP YP_892577.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_892578.1 identified by match to protein family HMM PF00593; match to protein family HMM PF07715; match to protein family HMM TIGR01783 YP_892579.1 identified by match to protein family HMM PF00005 YP_892580.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_892581.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_892583.1 identified by match to protein family HMM PF02578; match to protein family HMM TIGR00726 YP_892584.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_892585.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_892587.1 identified by match to protein family HMM PF00355; match to protein family HMM TIGR01409; match to protein family HMM TIGR01416 YP_892588.1 identified by match to protein family HMM PF00032; match to protein family HMM PF00033 YP_892591.1 identified by match to protein family HMM PF04055 YP_892592.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_892593.1 identified by match to protein family HMM PF03350 YP_892594.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_892595.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00158 YP_892597.1 identified by match to protein family HMM PF04164 YP_892598.1 negatively supercoils closed circular double-stranded DNA YP_892601.1 identified by match to protein family HMM PF00583 YP_892602.1 identified by match to protein family HMM PF00501 YP_892606.1 identified by match to protein family HMM PF01361; match to protein family HMM TIGR00013 YP_892607.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_892608.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_892609.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_892610.1 identified by match to protein family HMM PF01979; match to protein family HMM TIGR00857 YP_892614.1 identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532 YP_892616.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_892617.1 identified by match to protein family HMM TIGR01583 YP_892619.1 identified by match to protein family HMM PF03641; match to protein family HMM TIGR00730 YP_892620.1 identified by match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01318 YP_892621.1 identified by match to protein family HMM PF00310; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898 YP_892622.1 identified by match to protein family HMM PF00383; match to protein family HMM TIGR00326 YP_892625.1 similar to Tmden_0678; identified by match to protein family HMM PF02576 YP_892626.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_892627.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_892629.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_892631.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_892632.1 identified by match to protein family HMM PF02567; match to protein family HMM TIGR00654 YP_892633.1 identified by match to protein family HMM PF01551 YP_892634.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate YP_892635.1 identified by match to protein family HMM PF01103; match to protein family HMM PF07244 YP_892636.1 identified by match to protein family HMM PF03473 YP_892637.1 identified by match to protein family HMM PF01343; match to protein family HMM TIGR00706 YP_892638.1 Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline YP_892639.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_892640.1 identified by match to protein family HMM PF00557 YP_892641.1 identified by match to protein family HMM PF01288; match to protein family HMM TIGR01498 YP_892642.1 positive regulator of class III flagellar genes YP_892643.1 identified by match to protein family HMM PF01656 YP_892645.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes YP_892646.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_892647.1 One of three proteins involved in switching the direction of the flagellar rotation YP_892648.1 identified by match to protein family HMM PF01171; match to protein family HMM PF06508 YP_892649.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_892650.1 identified by match to protein family HMM TIGR00128 YP_892651.1 identified by match to protein family HMM PF00254 YP_892652.1 identified by match to protein family HMM PF07719 YP_892653.1 identified by match to protein family HMM PF00691 YP_892654.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_892656.1 identified by match to protein family HMM PF02472 YP_892657.1 identified by match to protein family HMM PF01618 YP_892658.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_892659.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_892660.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_892661.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_892662.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The delta subunit is part of the catalytic core of the ATP synthase complex YP_892663.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_892664.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B' is part of the membrane proton channel. YP_892665.1 identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180 YP_892666.1 identified by match to protein family HMM PF01656 YP_892667.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_892668.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_892669.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_892670.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_892671.1 involved in the peptidyltransferase reaction during translation YP_892672.1 identified by match to protein family HMM PF00829; match to protein family HMM TIGR00061 YP_892673.1 identified by match to protein family HMM PF03150 YP_892674.1 identified by match to protein family HMM PF00037 YP_892675.1 identified by match to protein family HMM PF00384; match to protein family HMM PF01568 YP_892676.1 identified by match to protein family HMM TIGR01409 YP_892678.1 identified by match to protein family HMM PF00037 YP_892679.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_892680.1 identified by match to protein family HMM PF00009; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR00475 YP_892682.1 identified by match to protein family HMM PF02348 YP_892683.1 identified by match to protein family HMM PF01261 YP_892689.1 identified by match to protein family HMM PF01354; match to protein family HMM PF03102 YP_892690.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_892691.1 identified by match to protein family HMM PF02621 YP_892692.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_892693.1 identified by match to protein family HMM PF00390; match to protein family HMM PF03949 YP_892694.1 identified by match to protein family HMM PF01047 YP_892695.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_892697.1 biotin carboxylase; biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA; catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_892698.1 identified by match to protein family HMM PF00364; match to protein family HMM TIGR00531 YP_892699.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_892700.1 identified by match to protein family HMM PF01041; match to protein family HMM PF01212 YP_892701.1 identified by match to protein family HMM PF00037; match to protein family HMM PF02754 YP_892702.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_892704.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_892706.1 identified by match to protein family HMM PF00185; match to protein family HMM PF02729; match to protein family HMM TIGR00658 YP_892707.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_892708.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_892709.1 identified by match to protein family HMM PF02527; match to protein family HMM TIGR00138 YP_892712.1 identified by match to protein family HMM PF01435 YP_892713.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_892716.1 identified by match to protein family HMM PF04314 YP_892718.1 identified by match to protein family HMM PF04055 YP_892719.1 identified by match to protein family HMM PF04055 YP_892720.1 identified by match to protein family HMM PF00456 YP_892721.1 identified by match to protein family HMM TIGR01444 YP_892722.1 identified by match to protein family HMM PF02779; match to protein family HMM PF02780 YP_892724.1 identified by match to protein family HMM PF01596 YP_892725.1 identified by match to protein family HMM PF04055 YP_892726.1 identified by match to protein family HMM PF04055 YP_892733.1 identified by match to protein family HMM PF04055 YP_892734.1 identified by match to protein family HMM PF03275 YP_892741.1 identified by match to protein family HMM PF00310; match to protein family HMM PF00733; match to protein family HMM TIGR01536 YP_892742.1 identified by match to protein family HMM PF00534 YP_892745.1 identified by match to protein family HMM PF00534 YP_892746.1 identified by match to protein family HMM PF00310; match to protein family HMM PF00733; match to protein family HMM TIGR01536 YP_892747.1 identified by match to protein family HMM PF04007 YP_892756.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis YP_892759.1 identified by match to protein family HMM PF00117 YP_892760.1 identified by match to protein family HMM PF00483 YP_892761.1 identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF07993 YP_892762.1 identified by match to protein family HMM PF00583 YP_892763.1 FlaB; structural flagella protein; in Helicobacter flagella are composed of flagellin A and flagellin B; the amounts of each seem to be controlled by environmental conditions YP_892764.1 FlaB; structural flagella protein; in Helicobacter flagella are composed of flagellin A and flagellin B; the amounts of each seem to be controlled by environmental conditions YP_892766.1 identified by match to protein family HMM PF01973 YP_892768.1 identified by match to protein family HMM PF01594 YP_892769.1 identified by match to protein family HMM PF02386; match to protein family HMM TIGR00933 YP_892770.1 identified by match to protein family HMM PF02254 YP_892771.1 catalyzes the formation of fumarate from aspartate YP_892772.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_892773.1 identified by match to protein family HMM PF00015 YP_892774.1 identified by match to protein family HMM PF02600 YP_892776.1 identified by match to protein family HMM PF00593; match to protein family HMM PF07715 YP_892777.1 identified by match to protein family HMM PF01618; match to protein family HMM TIGR02805 YP_892778.1 identified by match to protein family HMM PF02472; match to protein family HMM TIGR02804 YP_892779.1 identified by match to protein family HMM PF03544; match to protein family HMM TIGR01352 YP_892780.1 identified by match to protein family HMM PF00496 YP_892781.1 identified by match to protein family HMM PF00528 YP_892782.1 identified by match to protein family HMM PF00528 YP_892783.1 identified by match to protein family HMM PF00005 YP_892784.1 identified by match to protein family HMM PF02040; match to protein family HMM PF03600 YP_892788.1 identified by match to protein family HMM PF03738 YP_892789.1 identified by match to protein family HMM PF02441; match to protein family HMM TIGR00421 YP_892790.1 Involved in the metabolism of aromatic amino acids YP_892791.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_892793.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_892794.1 identified by match to protein family HMM PF00004 YP_892795.1 activates fatty acids by binding to coenzyme A YP_892796.1 identified by match to protein family HMM PF03349 YP_892797.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_892802.1 identified by match to protein family HMM PF03787 YP_892806.1 identified by match to protein family HMM PF03741 YP_892807.1 identified by match to protein family HMM PF00551; match to protein family HMM TIGR00639 YP_892808.1 similar to N-terminus; identified by match to protein family HMM PF01256; match to protein family HMM PF03853; match to protein family HMM TIGR00196; match to protein family HMM TIGR00197 YP_892809.1 identified by match to protein family HMM PF01078; match to protein family HMM PF07728; match to protein family HMM TIGR00368 YP_892810.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_892811.1 identified by match to protein family HMM PF00990; match to protein family HMM TIGR00254 YP_892812.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_892813.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_892814.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_892815.1 involved in type III protein export during flagellum assembly YP_892816.1 identified by match to protein family HMM PF00266; match to protein family HMM PF01212 YP_892817.1 identified by match to protein family HMM PF01106; match to protein family HMM PF01592; match to protein family HMM PF04324 YP_892818.1 identified by match to protein family HMM PF00015; match to protein family HMM PF02743 YP_892819.1 identified by match to protein family HMM PF01814; match to protein family HMM TIGR02481 YP_892820.1 identified by match to protein family HMM PF05154 YP_892821.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_892822.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_892825.1 identified by match to protein family HMM PF05016 YP_892830.1 identified by match to protein family HMM PF00589 YP_892832.1 identified by match to protein family HMM PF03653 YP_892833.1 identified by match to protein family HMM PF05154 YP_892834.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_892835.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_892836.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_892837.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_892838.1 identified by match to protein family HMM PF04237 YP_892839.1 identified by match to protein family HMM PF00857 YP_892840.1 identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633 YP_892841.1 identified by match to protein family HMM PF00884; match to protein family HMM PF08019 YP_892842.1 identified by match to protein family HMM PF01219 YP_892844.1 identified by match to protein family HMM PF02659 YP_892845.1 identified by match to protein family HMM PF00892 YP_892846.1 identified by match to protein family HMM PF00950; match to protein family HMM PF01032 YP_892847.1 identified by match to protein family HMM PF00005 YP_892848.1 identified by match to protein family HMM PF03824 YP_892849.1 identified by match to protein family HMM PF01297 YP_892852.1 identified by match to protein family HMM PF03150 YP_892853.1 identified by match to protein family HMM PF00563; match to protein family HMM PF00989; match to protein family HMM PF00990; match to protein family HMM TIGR00229 YP_892854.1 identified by match to protein family HMM PF00484 YP_892855.1 identified by match to protein family HMM PF00924 YP_892859.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_892860.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_892861.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_892862.1 identified by match to protein family HMM PF07719 YP_892863.1 synthesizes RNA primers at the replication forks YP_892864.1 identified by match to protein family HMM PF00764 YP_892866.1 identified by match to protein family HMM PF04402 YP_892867.1 identified by match to protein family HMM PF03553; match to protein family HMM PF03600; match to protein family HMM PF06808 YP_892869.1 identified by match to protein family HMM PF03062 YP_892870.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_892871.1 identified by match to protein family HMM PF00149; match to protein family HMM PF02872 YP_892872.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_892873.1 identified by match to protein family HMM PF01368; match to protein family HMM PF02272; match to protein family HMM TIGR00644 YP_892874.1 identified by match to protein family HMM PF06965; match to protein family HMM TIGR00773 YP_892875.1 identified by match to protein family HMM PF00005 YP_892876.1 identified by match to protein family HMM PF01243 YP_892878.1 identified by match to protein family HMM PF00593; match to protein family HMM PF07715 YP_892879.1 identified by match to protein family HMM PF01032 YP_892880.1 identified by match to protein family HMM PF00005 YP_892881.1 identified by match to protein family HMM PF01497 YP_892884.1 the hook connects flagellar basal body to the flagellar filament YP_892885.1 identified by match to protein family HMM PF01832 YP_892886.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_892887.1 identified by match to protein family HMM PF01121; match to protein family HMM TIGR00152 YP_892888.1 identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004 YP_892889.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_892890.1 identified by match to protein family HMM PF01734 YP_892891.1 identified by match to protein family HMM PF00004 YP_892892.1 identified by match to protein family HMM PF00892 YP_892893.1 identified by match to protein family HMM PF00578 YP_892894.1 identified by match to protein family HMM PF06271 YP_892895.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_892896.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_892897.1 identified by match to protein family HMM PF01522 YP_892898.1 identified by match to protein family HMM PF03840; match to protein family HMM TIGR00810 YP_892899.1 identified by match to protein family HMM PF01027 YP_892901.1 identified by match to protein family HMM PF00082; match to protein family HMM PF03797 YP_892902.1 identified by match to protein family HMM PF02525 YP_892908.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor YP_892909.1 identified by match to protein family HMM PF00732 YP_892911.1 identified by match to protein family HMM PF07681 YP_892913.1 identified by match to protein family HMM PF00881 YP_892916.1 identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093 YP_892917.1 identified by match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393 YP_892918.1 identified by match to protein family HMM PF00753; match to protein family HMM PF07521; match to protein family HMM TIGR00649 YP_892919.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_892920.1 identified by match to protein family HMM PF05977; match to protein family HMM PF07690 YP_892921.1 identified by match to protein family HMM PF00977; match to protein family HMM TIGR00735 YP_892923.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_892924.1 identified by match to protein family HMM PF04993 YP_892925.1 similar to jhp_0321; identified by match to protein family HMM PF00849 YP_892926.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_892927.1 Catalyzes the rate-limiting step in dNTP synthesis YP_892928.1 identified by match to protein family HMM PF00324 YP_892929.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity