-- dump date 20140619_021636 -- class Genbank::misc_feature -- table misc_feature_note -- id note 407148000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 407148000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148000003 Walker A motif; other site 407148000004 ATP binding site [chemical binding]; other site 407148000005 Walker B motif; other site 407148000006 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 407148000007 DnaA box-binding interface [nucleotide binding]; other site 407148000008 DNA polymerase III subunit beta; Validated; Region: PRK05643 407148000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 407148000010 putative DNA binding surface [nucleotide binding]; other site 407148000011 dimer interface [polypeptide binding]; other site 407148000012 beta-clamp/clamp loader binding surface; other site 407148000013 beta-clamp/translesion DNA polymerase binding surface; other site 407148000014 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 407148000015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 407148000016 Mg2+ binding site [ion binding]; other site 407148000017 G-X-G motif; other site 407148000018 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 407148000019 anchoring element; other site 407148000020 dimer interface [polypeptide binding]; other site 407148000021 ATP binding site [chemical binding]; other site 407148000022 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 407148000023 active site 407148000024 putative metal-binding site [ion binding]; other site 407148000025 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 407148000026 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 407148000027 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 407148000028 sulfite oxidase; Provisional; Region: PLN00177 407148000029 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 407148000030 Moco binding site; other site 407148000031 metal coordination site [ion binding]; other site 407148000032 dimerization interface [polypeptide binding]; other site 407148000033 Predicted permease [General function prediction only]; Region: COG2056 407148000034 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 407148000035 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 407148000036 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 407148000037 active site 407148000038 dimer interface [polypeptide binding]; other site 407148000039 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 407148000040 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 407148000041 active site 407148000042 FMN binding site [chemical binding]; other site 407148000043 substrate binding site [chemical binding]; other site 407148000044 3Fe-4S cluster binding site [ion binding]; other site 407148000045 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 407148000046 domain interface; other site 407148000047 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 407148000048 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 407148000049 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 407148000050 RNA/DNA hybrid binding site [nucleotide binding]; other site 407148000051 active site 407148000052 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 407148000053 Helix-hairpin-helix motif; Region: HHH; pfam00633 407148000054 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 407148000055 non-heme iron binding site [ion binding]; other site 407148000056 dimer interface [polypeptide binding]; other site 407148000057 Rubrerythrin [Energy production and conversion]; Region: COG1592 407148000058 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 407148000059 binuclear metal center [ion binding]; other site 407148000060 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 407148000061 iron binding site [ion binding]; other site 407148000062 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 407148000063 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 407148000064 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 407148000065 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 407148000066 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 407148000067 Ligand Binding Site [chemical binding]; other site 407148000068 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 407148000069 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 407148000070 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 407148000071 dimer interface [polypeptide binding]; other site 407148000072 putative CheW interface [polypeptide binding]; other site 407148000073 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 407148000074 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 407148000075 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 407148000076 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 407148000077 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 407148000078 active site 407148000079 adenylosuccinate lyase; Provisional; Region: PRK08470 407148000080 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 407148000081 tetramer interface [polypeptide binding]; other site 407148000082 active site 407148000083 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 407148000084 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 407148000085 ATP cone domain; Region: ATP-cone; pfam03477 407148000086 Class I ribonucleotide reductase; Region: RNR_I; cd01679 407148000087 active site 407148000088 dimer interface [polypeptide binding]; other site 407148000089 catalytic residues [active] 407148000090 effector binding site; other site 407148000091 R2 peptide binding site; other site 407148000092 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 407148000093 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 407148000094 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 407148000095 CTP synthetase; Validated; Region: pyrG; PRK05380 407148000096 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 407148000097 Catalytic site [active] 407148000098 active site 407148000099 UTP binding site [chemical binding]; other site 407148000100 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 407148000101 active site 407148000102 putative oxyanion hole; other site 407148000103 catalytic triad [active] 407148000104 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 407148000105 DHH family; Region: DHH; pfam01368 407148000106 DHHA1 domain; Region: DHHA1; pfam02272 407148000107 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 407148000108 active site 407148000109 homotetramer interface [polypeptide binding]; other site 407148000110 homodimer interface [polypeptide binding]; other site 407148000111 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 407148000112 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 407148000113 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 407148000114 heme-binding residues [chemical binding]; other site 407148000115 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 407148000116 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 407148000117 heme-binding residues [chemical binding]; other site 407148000118 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 407148000119 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 407148000120 catalytic residues [active] 407148000121 ResB-like family; Region: ResB; pfam05140 407148000122 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 407148000123 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 407148000124 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 407148000125 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 407148000126 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 407148000127 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 407148000128 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 407148000129 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 407148000130 DNA polymerase III PolC; Validated; Region: polC; PRK00448 407148000131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 407148000132 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 407148000133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148000134 putative substrate translocation pore; other site 407148000135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 407148000136 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 407148000137 Cytochrome c [Energy production and conversion]; Region: COG3258 407148000138 Cytochrome c; Region: Cytochrom_C; pfam00034 407148000139 Cytochrome c; Region: Cytochrom_C; pfam00034 407148000140 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 407148000141 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 407148000142 G1 box; other site 407148000143 putative GEF interaction site [polypeptide binding]; other site 407148000144 GTP/Mg2+ binding site [chemical binding]; other site 407148000145 Switch I region; other site 407148000146 G2 box; other site 407148000147 G3 box; other site 407148000148 Switch II region; other site 407148000149 G4 box; other site 407148000150 G5 box; other site 407148000151 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 407148000152 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 407148000153 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 407148000154 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 407148000155 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 407148000156 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 407148000157 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 407148000158 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 407148000159 Protein of unknown function (DUF342); Region: DUF342; pfam03961 407148000160 Hemerythrin; Region: Hemerythrin; cd12107 407148000161 Fe binding site [ion binding]; other site 407148000162 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 407148000163 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 407148000164 Ligand Binding Site [chemical binding]; other site 407148000165 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 407148000166 flagellar motor switch protein FliY; Validated; Region: PRK08432 407148000167 flagellar motor switch protein FliN; Region: fliN; TIGR02480 407148000168 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 407148000169 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 407148000170 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 407148000171 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 407148000172 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 407148000173 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 407148000174 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 407148000175 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 407148000176 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 407148000177 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 407148000178 catalytic center binding site [active] 407148000179 ATP binding site [chemical binding]; other site 407148000180 Dehydroquinase class II; Region: DHquinase_II; pfam01220 407148000181 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 407148000182 trimer interface [polypeptide binding]; other site 407148000183 active site 407148000184 dimer interface [polypeptide binding]; other site 407148000185 chlorohydrolase; Provisional; Region: PRK08418 407148000186 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 407148000187 active site 407148000188 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 407148000189 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 407148000190 tandem repeat interface [polypeptide binding]; other site 407148000191 oligomer interface [polypeptide binding]; other site 407148000192 active site residues [active] 407148000193 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 407148000194 Hemerythrin; Region: Hemerythrin; cd12107 407148000195 Fe binding site [ion binding]; other site 407148000196 Hemerythrin; Region: Hemerythrin; cd12107 407148000197 Fe binding site [ion binding]; other site 407148000198 Uncharacterized conserved protein [Function unknown]; Region: COG1556 407148000199 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 407148000200 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 407148000201 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 407148000202 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 407148000203 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 407148000204 Cysteine-rich domain; Region: CCG; pfam02754 407148000205 Cysteine-rich domain; Region: CCG; pfam02754 407148000206 L-lactate permease; Region: Lactate_perm; cl00701 407148000207 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 407148000208 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 407148000209 CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081 407148000210 putative catalytic site [active] 407148000211 CdtC interface [polypeptide binding]; other site 407148000212 heterotrimer interface [polypeptide binding]; other site 407148000213 CdtA interface [polypeptide binding]; other site 407148000214 putative metal binding site [ion binding]; other site 407148000215 putative phosphate binding site [ion binding]; other site 407148000216 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 407148000217 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 407148000218 putative sugar binding sites [chemical binding]; other site 407148000219 Q-X-W motif; other site 407148000220 Cytochrome bd-type quinol oxidase, subunit 1 [Energy production and conversion]; Region: CydA; COG1271 407148000221 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 407148000222 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 407148000223 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 407148000224 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 407148000225 aspartate racemase; Region: asp_race; TIGR00035 407148000226 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 407148000227 ligand binding site [chemical binding]; other site 407148000228 active site 407148000229 UGI interface [polypeptide binding]; other site 407148000230 catalytic site [active] 407148000231 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 407148000232 Aspartase; Region: Aspartase; cd01357 407148000233 active sites [active] 407148000234 tetramer interface [polypeptide binding]; other site 407148000235 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 407148000236 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 407148000237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 407148000238 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 407148000239 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 407148000240 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 407148000241 putative dimer interface [polypeptide binding]; other site 407148000242 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 407148000243 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 407148000244 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 407148000245 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 407148000246 GTPase CgtA; Reviewed; Region: obgE; PRK12299 407148000247 GTP1/OBG; Region: GTP1_OBG; pfam01018 407148000248 Obg GTPase; Region: Obg; cd01898 407148000249 G1 box; other site 407148000250 GTP/Mg2+ binding site [chemical binding]; other site 407148000251 Switch I region; other site 407148000252 G2 box; other site 407148000253 G3 box; other site 407148000254 Switch II region; other site 407148000255 G4 box; other site 407148000256 G5 box; other site 407148000257 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 407148000258 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 407148000259 nucleotide binding site [chemical binding]; other site 407148000260 homotetrameric interface [polypeptide binding]; other site 407148000261 putative phosphate binding site [ion binding]; other site 407148000262 putative allosteric binding site; other site 407148000263 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 407148000264 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 407148000265 putative active site [active] 407148000266 substrate binding site [chemical binding]; other site 407148000267 putative cosubstrate binding site; other site 407148000268 catalytic site [active] 407148000269 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 407148000270 substrate binding site [chemical binding]; other site 407148000271 biotin--protein ligase; Provisional; Region: PRK08477 407148000272 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 407148000273 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 407148000274 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 407148000275 P-loop; other site 407148000276 Magnesium ion binding site [ion binding]; other site 407148000277 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 407148000278 Magnesium ion binding site [ion binding]; other site 407148000279 ParB-like nuclease domain; Region: ParB; smart00470 407148000280 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 407148000281 F0F1 ATP synthase subunit B'; Validated; Region: PRK08476 407148000282 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 407148000283 F0F1 ATP synthase subunit B; Validated; Region: PRK08475 407148000284 F0F1 ATP synthase subunit delta; Validated; Region: PRK08474 407148000285 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 407148000286 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 407148000287 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 407148000288 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 407148000289 beta subunit interaction interface [polypeptide binding]; other site 407148000290 Walker A motif; other site 407148000291 ATP binding site [chemical binding]; other site 407148000292 Walker B motif; other site 407148000293 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 407148000294 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 407148000295 core domain interface [polypeptide binding]; other site 407148000296 delta subunit interface [polypeptide binding]; other site 407148000297 epsilon subunit interface [polypeptide binding]; other site 407148000298 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 407148000299 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 407148000300 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 407148000301 alpha subunit interaction interface [polypeptide binding]; other site 407148000302 Walker A motif; other site 407148000303 ATP binding site [chemical binding]; other site 407148000304 Walker B motif; other site 407148000305 inhibitor binding site; inhibition site 407148000306 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 407148000307 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 407148000308 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 407148000309 gamma subunit interface [polypeptide binding]; other site 407148000310 epsilon subunit interface [polypeptide binding]; other site 407148000311 LBP interface [polypeptide binding]; other site 407148000312 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 407148000313 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 407148000314 TolR protein; Region: tolR; TIGR02801 407148000315 TonB C terminal; Region: TonB_2; pfam13103 407148000316 translocation protein TolB; Provisional; Region: tolB; PRK04043 407148000317 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 407148000318 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 407148000319 ligand binding site [chemical binding]; other site 407148000320 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 407148000321 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 407148000322 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 407148000323 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 407148000324 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 407148000325 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 407148000326 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 407148000327 Ligand Binding Site [chemical binding]; other site 407148000328 Isochorismatase family; Region: Isochorismatase; pfam00857 407148000329 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 407148000330 catalytic triad [active] 407148000331 conserved cis-peptide bond; other site 407148000332 putative recombination protein RecO; Provisional; Region: PRK13908 407148000333 metal-binding heat shock protein; Provisional; Region: PRK00016 407148000334 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 407148000335 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 407148000336 FMN binding site [chemical binding]; other site 407148000337 active site 407148000338 catalytic residues [active] 407148000339 substrate binding site [chemical binding]; other site 407148000340 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 407148000341 Uncharacterized conserved protein [Function unknown]; Region: COG1576 407148000342 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 407148000343 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 407148000344 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 407148000345 Putative fructose-1,6-bisphosphatase or related enzymes of inositol monophosphatase family. These are Mg++ dependent phosphatases. Members in this family may have fructose-1,6-bisphosphatase and/or inositol-monophosphatase activity. Fructose-1; Region: Arch_FBPase_2; cd01642 407148000346 putative active site [active] 407148000347 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 407148000348 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 407148000349 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 407148000350 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 407148000351 Surface antigen; Region: Bac_surface_Ag; pfam01103 407148000352 prephenate dehydrogenase; Validated; Region: PRK08507 407148000353 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 407148000354 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 407148000355 Peptidase family M23; Region: Peptidase_M23; pfam01551 407148000356 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 407148000357 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 407148000358 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 407148000359 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 407148000360 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 407148000361 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 407148000362 putative RNA binding cleft [nucleotide binding]; other site 407148000363 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 407148000364 translation initiation factor IF-2; Region: IF-2; TIGR00487 407148000365 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 407148000366 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 407148000367 G1 box; other site 407148000368 putative GEF interaction site [polypeptide binding]; other site 407148000369 GTP/Mg2+ binding site [chemical binding]; other site 407148000370 Switch I region; other site 407148000371 G2 box; other site 407148000372 G3 box; other site 407148000373 Switch II region; other site 407148000374 G4 box; other site 407148000375 G5 box; other site 407148000376 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 407148000377 Translation-initiation factor 2; Region: IF-2; pfam11987 407148000378 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 407148000379 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 407148000380 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 407148000381 Sm and related proteins; Region: Sm_like; cl00259 407148000382 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 407148000383 putative oligomer interface [polypeptide binding]; other site 407148000384 putative RNA binding site [nucleotide binding]; other site 407148000385 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 407148000386 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 407148000387 cofactor binding site; other site 407148000388 DNA binding site [nucleotide binding] 407148000389 substrate interaction site [chemical binding]; other site 407148000390 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 407148000391 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 407148000392 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 407148000393 dimer interface [polypeptide binding]; other site 407148000394 putative PBP binding regions; other site 407148000395 ABC-ATPase subunit interface; other site 407148000396 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 407148000397 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 407148000398 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 407148000399 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 407148000400 putative metal binding residues [ion binding]; other site 407148000401 Cache domain; Region: Cache_1; pfam02743 407148000402 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 407148000403 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 407148000404 dimer interface [polypeptide binding]; other site 407148000405 putative CheW interface [polypeptide binding]; other site 407148000406 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 407148000407 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 407148000408 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 407148000409 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 407148000410 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 407148000411 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 407148000412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 407148000413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 407148000414 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 407148000415 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 407148000416 catalytic residues [active] 407148000417 Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792 407148000418 homoserine dehydrogenase; Provisional; Region: PRK06349 407148000419 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 407148000420 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 407148000421 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 407148000422 aspartate aminotransferase; Provisional; Region: PRK08636 407148000423 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 407148000424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148000425 homodimer interface [polypeptide binding]; other site 407148000426 catalytic residue [active] 407148000427 Helix-turn-helix domain; Region: HTH_25; pfam13413 407148000428 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 407148000429 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 407148000430 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 407148000431 Predicted methyltransferases [General function prediction only]; Region: COG0313 407148000432 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 407148000433 putative SAM binding site [chemical binding]; other site 407148000434 putative homodimer interface [polypeptide binding]; other site 407148000435 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 407148000436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 407148000437 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 407148000438 queuosine biosynthesis protein QueD; Region: queuosine_QueD; TIGR03367 407148000439 active site 407148000440 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 407148000441 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 407148000442 FeS/SAM binding site; other site 407148000443 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 407148000444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 407148000445 FeS/SAM binding site; other site 407148000446 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 407148000447 prenyltransferase; Reviewed; Region: ubiA; PRK12874 407148000448 UbiA prenyltransferase family; Region: UbiA; pfam01040 407148000449 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 407148000450 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 407148000451 Predicted membrane protein [Function unknown]; Region: COG1971 407148000452 Domain of unknown function DUF; Region: DUF204; pfam02659 407148000453 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 407148000454 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 407148000455 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 407148000456 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 407148000457 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 407148000458 NAD(P) binding pocket [chemical binding]; other site 407148000459 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 407148000460 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 407148000461 Walker A/P-loop; other site 407148000462 ATP binding site [chemical binding]; other site 407148000463 Q-loop/lid; other site 407148000464 ABC transporter signature motif; other site 407148000465 Walker B; other site 407148000466 D-loop; other site 407148000467 H-loop/switch region; other site 407148000468 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 407148000469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148000470 dimer interface [polypeptide binding]; other site 407148000471 conserved gate region; other site 407148000472 putative PBP binding loops; other site 407148000473 ABC-ATPase subunit interface; other site 407148000474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148000475 dimer interface [polypeptide binding]; other site 407148000476 conserved gate region; other site 407148000477 putative PBP binding loops; other site 407148000478 ABC-ATPase subunit interface; other site 407148000479 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 407148000480 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 407148000481 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 407148000482 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 407148000483 Domain of unknown function DUF21; Region: DUF21; pfam01595 407148000484 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 407148000485 Transporter associated domain; Region: CorC_HlyC; smart01091 407148000486 Predicted kinase [General function prediction only]; Region: COG4639 407148000487 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 407148000488 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 407148000489 active site 407148000490 metal binding site [ion binding]; metal-binding site 407148000491 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 407148000492 PhnA protein; Region: PhnA; pfam03831 407148000493 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 407148000494 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 407148000495 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 407148000496 active site 407148000497 substrate binding site [chemical binding]; other site 407148000498 cosubstrate binding site; other site 407148000499 catalytic site [active] 407148000500 Uncharacterized conserved protein [Function unknown]; Region: COG0062 407148000501 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 407148000502 putative substrate binding site [chemical binding]; other site 407148000503 putative ATP binding site [chemical binding]; other site 407148000504 Uncharacterized conserved protein [Function unknown]; Region: COG1432 407148000505 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 407148000506 putative metal binding site [ion binding]; other site 407148000507 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 407148000508 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 407148000509 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 407148000510 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 407148000511 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 407148000512 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 407148000513 active site 407148000514 catalytic residues [active] 407148000515 metal binding site [ion binding]; metal-binding site 407148000516 Clp protease; Region: CLP_protease; pfam00574 407148000517 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 407148000518 oligomer interface [polypeptide binding]; other site 407148000519 active site residues [active] 407148000520 trigger factor; Provisional; Region: tig; PRK01490 407148000521 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 407148000522 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 407148000523 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 407148000524 homodecamer interface [polypeptide binding]; other site 407148000525 GTP cyclohydrolase I; Provisional; Region: PLN03044 407148000526 active site 407148000527 putative catalytic site residues [active] 407148000528 zinc binding site [ion binding]; other site 407148000529 GTP-CH-I/GFRP interaction surface; other site 407148000530 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 407148000531 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 407148000532 Walker A motif/ATP binding site; other site 407148000533 Walker B motif; other site 407148000534 amidophosphoribosyltransferase; Provisional; Region: PRK08525 407148000535 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 407148000536 active site 407148000537 tetramer interface [polypeptide binding]; other site 407148000538 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 407148000539 active site 407148000540 dihydrodipicolinate reductase; Provisional; Region: PRK00048 407148000541 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 407148000542 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 407148000543 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 407148000544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148000545 Walker A motif; other site 407148000546 ATP binding site [chemical binding]; other site 407148000547 Walker B motif; other site 407148000548 arginine finger; other site 407148000549 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 407148000550 DNA polymerase III PolC; Validated; Region: polC; PRK00448 407148000551 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 407148000552 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 407148000553 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 407148000554 Citrate transporter; Region: CitMHS; pfam03600 407148000555 Predicted membrane protein [Function unknown]; Region: COG1297 407148000556 putative oligopeptide transporter, OPT family; Region: TIGR00733 407148000557 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 407148000558 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 407148000559 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 407148000560 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 407148000561 active site 407148000562 dimer interface [polypeptide binding]; other site 407148000563 motif 1; other site 407148000564 motif 2; other site 407148000565 motif 3; other site 407148000566 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 407148000567 anticodon binding site; other site 407148000568 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 407148000569 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 407148000570 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 407148000571 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 407148000572 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 407148000573 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 407148000574 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 407148000575 Autotransporter beta-domain; Region: Autotransporter; smart00869 407148000576 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 407148000577 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 407148000578 putative acetyltransferase; Provisional; Region: PRK03624 407148000579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 407148000580 Coenzyme A binding pocket [chemical binding]; other site 407148000581 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 407148000582 feedback inhibition sensing region; other site 407148000583 homohexameric interface [polypeptide binding]; other site 407148000584 nucleotide binding site [chemical binding]; other site 407148000585 N-acetyl-L-glutamate binding site [chemical binding]; other site 407148000586 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 407148000587 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 407148000588 inhibitor-cofactor binding pocket; inhibition site 407148000589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148000590 catalytic residue [active] 407148000591 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 407148000592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148000593 S-adenosylmethionine binding site [chemical binding]; other site 407148000594 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 407148000595 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 407148000596 trimer interface [polypeptide binding]; other site 407148000597 putative metal binding site [ion binding]; other site 407148000598 putative nicotinate phosphoribosyltransferase; Region: NAPRTase_put; TIGR01513 407148000599 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 407148000600 active site 407148000601 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 407148000602 dimer interface [polypeptide binding]; other site 407148000603 putative radical transfer pathway; other site 407148000604 diiron center [ion binding]; other site 407148000605 tyrosyl radical; other site 407148000606 RDD family; Region: RDD; pfam06271 407148000607 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 407148000608 active site 407148000609 ribosome recycling factor; Reviewed; Region: frr; PRK00083 407148000610 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 407148000611 hinge region; other site 407148000612 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 407148000613 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 407148000614 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 407148000615 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 407148000616 active site clefts [active] 407148000617 zinc binding site [ion binding]; other site 407148000618 dimer interface [polypeptide binding]; other site 407148000619 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 407148000620 Mechanosensitive ion channel; Region: MS_channel; pfam00924 407148000621 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 407148000622 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 407148000623 trimerization site [polypeptide binding]; other site 407148000624 active site 407148000625 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 407148000626 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 407148000627 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 407148000628 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 407148000629 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 407148000630 catalytic residue [active] 407148000631 Hemerythrin; Region: Hemerythrin; cd12107 407148000632 Fe binding site [ion binding]; other site 407148000633 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 407148000634 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 407148000635 23S rRNA binding site [nucleotide binding]; other site 407148000636 L21 binding site [polypeptide binding]; other site 407148000637 L13 binding site [polypeptide binding]; other site 407148000638 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 407148000639 dimer interface [polypeptide binding]; other site 407148000640 putative CheW interface [polypeptide binding]; other site 407148000641 FIST N domain; Region: FIST; pfam08495 407148000642 FIST C domain; Region: FIST_C; pfam10442 407148000643 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 407148000644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148000645 metabolite-proton symporter; Region: 2A0106; TIGR00883 407148000646 putative substrate translocation pore; other site 407148000647 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 407148000648 trimer interface [polypeptide binding]; other site 407148000649 dimer interface [polypeptide binding]; other site 407148000650 putative active site [active] 407148000651 Protein of unknown function (DUF493); Region: DUF493; pfam04359 407148000652 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 407148000653 putative catalytic site [active] 407148000654 putative metal binding site [ion binding]; other site 407148000655 putative phosphate binding site [ion binding]; other site 407148000656 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 407148000657 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 407148000658 Sulfatase; Region: Sulfatase; pfam00884 407148000659 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 407148000660 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 407148000661 active site 407148000662 substrate binding pocket [chemical binding]; other site 407148000663 dimer interface [polypeptide binding]; other site 407148000664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148000665 S-adenosylmethionine binding site [chemical binding]; other site 407148000666 Cache domain; Region: Cache_1; pfam02743 407148000667 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 407148000668 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 407148000669 dimer interface [polypeptide binding]; other site 407148000670 putative CheW interface [polypeptide binding]; other site 407148000671 zinc transporter ZupT; Provisional; Region: PRK04201 407148000672 ZIP Zinc transporter; Region: Zip; pfam02535 407148000673 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 407148000674 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 407148000675 molybdopterin cofactor binding site [chemical binding]; other site 407148000676 substrate binding site [chemical binding]; other site 407148000677 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 407148000678 molybdopterin cofactor binding site; other site 407148000679 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 407148000680 Cytochrome c; Region: Cytochrom_C; cl11414 407148000681 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 407148000682 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 407148000683 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 407148000684 SPFH domain / Band 7 family; Region: Band_7; pfam01145 407148000685 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 407148000686 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 407148000687 homodimer interface [polypeptide binding]; other site 407148000688 substrate-cofactor binding pocket; other site 407148000689 catalytic residue [active] 407148000690 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 407148000691 active site 1 [active] 407148000692 dimer interface [polypeptide binding]; other site 407148000693 hexamer interface [polypeptide binding]; other site 407148000694 active site 2 [active] 407148000695 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 407148000696 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 407148000697 catalytic triad [active] 407148000698 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 407148000699 Ligand Binding Site [chemical binding]; other site 407148000700 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 407148000701 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 407148000702 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 407148000703 active site 407148000704 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 407148000705 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 407148000706 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 407148000707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148000708 Walker A motif; other site 407148000709 ATP binding site [chemical binding]; other site 407148000710 Walker B motif; other site 407148000711 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 407148000712 rod shape-determining protein MreB; Provisional; Region: PRK13927 407148000713 MreB and similar proteins; Region: MreB_like; cd10225 407148000714 nucleotide binding site [chemical binding]; other site 407148000715 Mg binding site [ion binding]; other site 407148000716 putative protofilament interaction site [polypeptide binding]; other site 407148000717 RodZ interaction site [polypeptide binding]; other site 407148000718 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 407148000719 rod shape-determining protein MreC; Region: MreC; pfam04085 407148000720 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 407148000721 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 407148000722 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 407148000723 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 407148000724 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 407148000725 ATP-grasp domain; Region: ATP-grasp_4; cl17255 407148000726 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 407148000727 IMP binding site; other site 407148000728 dimer interface [polypeptide binding]; other site 407148000729 interdomain contacts; other site 407148000730 partial ornithine binding site; other site 407148000731 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 407148000732 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 407148000733 putative active site [active] 407148000734 transaldolase; Provisional; Region: PRK03903 407148000735 catalytic residue [active] 407148000736 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 407148000737 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 407148000738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 407148000739 motif II; other site 407148000740 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 407148000741 putative CheA interaction surface; other site 407148000742 chemotaxis protein CheA; Provisional; Region: PRK10547 407148000743 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 407148000744 putative binding surface; other site 407148000745 active site 407148000746 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 407148000747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 407148000748 ATP binding site [chemical binding]; other site 407148000749 Mg2+ binding site [ion binding]; other site 407148000750 G-X-G motif; other site 407148000751 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 407148000752 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 407148000753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 407148000754 active site 407148000755 phosphorylation site [posttranslational modification] 407148000756 intermolecular recognition site; other site 407148000757 dimerization interface [polypeptide binding]; other site 407148000758 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 407148000759 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 407148000760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 407148000761 active site 407148000762 phosphorylation site [posttranslational modification] 407148000763 intermolecular recognition site; other site 407148000764 dimerization interface [polypeptide binding]; other site 407148000765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2908 407148000766 active site 407148000767 metal binding site [ion binding]; metal-binding site 407148000768 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 407148000769 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 407148000770 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 407148000771 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 407148000772 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 407148000773 DEAD-like helicases superfamily; Region: DEXDc; smart00487 407148000774 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 407148000775 ATP binding site [chemical binding]; other site 407148000776 putative Mg++ binding site [ion binding]; other site 407148000777 Caspase domain; Region: Peptidase_C14; pfam00656 407148000778 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 407148000779 DNA methylase; Region: N6_N4_Mtase; pfam01555 407148000780 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 407148000781 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 407148000782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148000783 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 407148000784 putative substrate translocation pore; other site 407148000785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148000786 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 407148000787 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 407148000788 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 407148000789 ATP binding site [chemical binding]; other site 407148000790 substrate interface [chemical binding]; other site 407148000791 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 407148000792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 407148000793 Coenzyme A binding pocket [chemical binding]; other site 407148000794 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 407148000795 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 407148000796 tetramerization interface [polypeptide binding]; other site 407148000797 active site 407148000798 pantoate--beta-alanine ligase; Region: panC; TIGR00018 407148000799 Pantoate-beta-alanine ligase; Region: PanC; cd00560 407148000800 active site 407148000801 ATP-binding site [chemical binding]; other site 407148000802 pantoate-binding site; other site 407148000803 HXXH motif; other site 407148000804 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 407148000805 active site 407148000806 oligomerization interface [polypeptide binding]; other site 407148000807 metal binding site [ion binding]; metal-binding site 407148000808 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 407148000809 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 407148000810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 407148000811 Walker A/P-loop; other site 407148000812 ATP binding site [chemical binding]; other site 407148000813 Q-loop/lid; other site 407148000814 ABC transporter signature motif; other site 407148000815 Walker B; other site 407148000816 D-loop; other site 407148000817 H-loop/switch region; other site 407148000818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148000819 dimer interface [polypeptide binding]; other site 407148000820 conserved gate region; other site 407148000821 putative PBP binding loops; other site 407148000822 ABC-ATPase subunit interface; other site 407148000823 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 407148000824 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 407148000825 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 407148000826 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 407148000827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148000828 S-adenosylmethionine binding site [chemical binding]; other site 407148000829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 407148000830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2830 407148000831 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 407148000832 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 407148000833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 407148000834 catalytic residue [active] 407148000835 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 407148000836 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 407148000837 inhibitor-cofactor binding pocket; inhibition site 407148000838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148000839 catalytic residue [active] 407148000840 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 407148000841 AAA domain; Region: AAA_26; pfam13500 407148000842 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 407148000843 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 407148000844 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 407148000845 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 407148000846 5S rRNA interface [nucleotide binding]; other site 407148000847 CTC domain interface [polypeptide binding]; other site 407148000848 L16 interface [polypeptide binding]; other site 407148000849 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 407148000850 putative active site [active] 407148000851 catalytic residue [active] 407148000852 Predicted permeases [General function prediction only]; Region: COG0795 407148000853 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 407148000854 diaminopimelate decarboxylase; Region: lysA; TIGR01048 407148000855 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 407148000856 active site 407148000857 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 407148000858 substrate binding site [chemical binding]; other site 407148000859 catalytic residues [active] 407148000860 dimer interface [polypeptide binding]; other site 407148000861 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 407148000862 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 407148000863 active site 407148000864 motif I; other site 407148000865 motif II; other site 407148000866 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 407148000867 chorismate mutase domain of proteobacterial P-protein, clade 2; Region: CM_P2; TIGR01807 407148000868 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 407148000869 Prephenate dehydratase; Region: PDT; pfam00800 407148000870 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 407148000871 putative L-Phe binding site [chemical binding]; other site 407148000872 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 407148000873 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 407148000874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148000875 homodimer interface [polypeptide binding]; other site 407148000876 catalytic residue [active] 407148000877 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 407148000878 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 407148000879 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 407148000880 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 407148000881 FliG C-terminal domain; Region: FliG_C; pfam01706 407148000882 flagellar assembly protein H; Validated; Region: fliH; PRK06669 407148000883 Flagellar assembly protein FliH; Region: FliH; pfam02108 407148000884 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 407148000885 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 407148000886 TPP-binding site; other site 407148000887 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 407148000888 PYR/PP interface [polypeptide binding]; other site 407148000889 dimer interface [polypeptide binding]; other site 407148000890 TPP binding site [chemical binding]; other site 407148000891 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 407148000892 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 407148000893 metal binding site 2 [ion binding]; metal-binding site 407148000894 putative DNA binding helix; other site 407148000895 metal binding site 1 [ion binding]; metal-binding site 407148000896 structural Zn2+ binding site [ion binding]; other site 407148000897 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 407148000898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148000899 S-adenosylmethionine binding site [chemical binding]; other site 407148000900 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 407148000901 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 407148000902 generic binding surface II; other site 407148000903 generic binding surface I; other site 407148000904 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 407148000905 homodimer interface [polypeptide binding]; other site 407148000906 substrate-cofactor binding pocket; other site 407148000907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148000908 catalytic residue [active] 407148000909 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 407148000910 homotrimer interaction site [polypeptide binding]; other site 407148000911 putative active site [active] 407148000912 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 407148000913 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 407148000914 dimer interface [polypeptide binding]; other site 407148000915 active site 407148000916 CoA binding pocket [chemical binding]; other site 407148000917 putative phosphate acyltransferase; Provisional; Region: PRK05331 407148000918 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 407148000919 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 407148000920 active site 407148000921 multimer interface [polypeptide binding]; other site 407148000922 Ferredoxin [Energy production and conversion]; Region: COG1146 407148000923 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 407148000924 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 407148000925 dimer interface [polypeptide binding]; other site 407148000926 decamer (pentamer of dimers) interface [polypeptide binding]; other site 407148000927 catalytic triad [active] 407148000928 peroxidatic and resolving cysteines [active] 407148000929 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 407148000930 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 407148000931 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 407148000932 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 407148000933 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 407148000934 ligand binding site [chemical binding]; other site 407148000935 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 407148000936 flagellar motor protein MotA; Validated; Region: PRK08456 407148000937 DNA polymerase I; Provisional; Region: PRK05755 407148000938 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 407148000939 active site 407148000940 metal binding site 1 [ion binding]; metal-binding site 407148000941 putative 5' ssDNA interaction site; other site 407148000942 metal binding site 3; metal-binding site 407148000943 metal binding site 2 [ion binding]; metal-binding site 407148000944 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 407148000945 putative DNA binding site [nucleotide binding]; other site 407148000946 putative metal binding site [ion binding]; other site 407148000947 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 407148000948 active site 407148000949 catalytic site [active] 407148000950 substrate binding site [chemical binding]; other site 407148000951 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 407148000952 active site 407148000953 DNA binding site [nucleotide binding] 407148000954 catalytic site [active] 407148000955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148000956 metabolite-proton symporter; Region: 2A0106; TIGR00883 407148000957 putative substrate translocation pore; other site 407148000958 nuc_hydro_CjNH. Nucleoside hydrolases similar to Campylobacter jejuni nucleoside hydrolase. This group contains eukaryotic and bacterial proteins similar to C. jejuni nucleoside hydrolase. Nucleoside hydrolases cleave the N-glycosidic bond in...; Region: nuc_hydro_CjNH; cd02654 407148000959 active site 407148000960 Predicted membrane protein [Function unknown]; Region: COG1238 407148000961 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 407148000962 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 407148000963 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 407148000964 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 407148000965 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 407148000966 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 407148000967 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 407148000968 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 407148000969 Glutamine amidotransferase class-I; Region: GATase; pfam00117 407148000970 glutamine binding [chemical binding]; other site 407148000971 catalytic triad [active] 407148000972 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 407148000973 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 407148000974 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 407148000975 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 407148000976 active site 407148000977 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 407148000978 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 407148000979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148000980 catalytic residue [active] 407148000981 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 407148000982 substrate binding site [chemical binding]; other site 407148000983 active site 407148000984 catalytic residues [active] 407148000985 heterodimer interface [polypeptide binding]; other site 407148000986 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 407148000987 flagellar motor switch protein; Validated; Region: PRK08433 407148000988 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 407148000989 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 407148000990 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 407148000991 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 407148000992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 407148000993 active site 407148000994 phosphorylation site [posttranslational modification] 407148000995 intermolecular recognition site; other site 407148000996 dimerization interface [polypeptide binding]; other site 407148000997 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 407148000998 DNA binding site [nucleotide binding] 407148000999 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 407148001000 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 407148001001 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 407148001002 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 407148001003 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 407148001004 active site 407148001005 substrate binding site [chemical binding]; other site 407148001006 metal binding site [ion binding]; metal-binding site 407148001007 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 407148001008 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 407148001009 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 407148001010 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 407148001011 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 407148001012 Protein export membrane protein; Region: SecD_SecF; cl14618 407148001013 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 407148001014 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 407148001015 HlyD family secretion protein; Region: HlyD_3; pfam13437 407148001016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 407148001017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 407148001018 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 407148001019 4Fe-4S binding domain; Region: Fer4_5; pfam12801 407148001020 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 407148001021 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 407148001022 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 407148001023 hypothetical protein; Provisional; Region: PRK04081 407148001024 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 407148001025 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 407148001026 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 407148001027 putative ligand binding site [chemical binding]; other site 407148001028 putative NAD binding site [chemical binding]; other site 407148001029 catalytic site [active] 407148001030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 407148001031 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 407148001032 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 407148001033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148001034 Walker A motif; other site 407148001035 ATP binding site [chemical binding]; other site 407148001036 Walker B motif; other site 407148001037 arginine finger; other site 407148001038 Predicted membrane protein [Function unknown]; Region: COG2717 407148001039 TMAO/DMSO reductase; Reviewed; Region: PRK05363 407148001040 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 407148001041 Moco binding site; other site 407148001042 metal coordination site [ion binding]; other site 407148001043 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 407148001044 active site 407148001045 dimer interface [polypeptide binding]; other site 407148001046 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 407148001047 putative RNA binding site [nucleotide binding]; other site 407148001048 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 407148001049 homopentamer interface [polypeptide binding]; other site 407148001050 active site 407148001051 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 407148001052 EamA-like transporter family; Region: EamA; pfam00892 407148001053 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 407148001054 GTP-binding protein Der; Reviewed; Region: PRK00093 407148001055 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 407148001056 G1 box; other site 407148001057 GTP/Mg2+ binding site [chemical binding]; other site 407148001058 Switch I region; other site 407148001059 G2 box; other site 407148001060 Switch II region; other site 407148001061 G3 box; other site 407148001062 G4 box; other site 407148001063 G5 box; other site 407148001064 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 407148001065 GTP/Mg2+ binding site [chemical binding]; other site 407148001066 Switch I region; other site 407148001067 G2 box; other site 407148001068 G3 box; other site 407148001069 Switch II region; other site 407148001070 G4 box; other site 407148001071 G5 box; other site 407148001072 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 407148001073 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 407148001074 ADP binding site [chemical binding]; other site 407148001075 magnesium binding site [ion binding]; other site 407148001076 putative shikimate binding site; other site 407148001077 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 407148001078 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 407148001079 active site 407148001080 HIGH motif; other site 407148001081 dimer interface [polypeptide binding]; other site 407148001082 KMSKS motif; other site 407148001083 seryl-tRNA synthetase; Provisional; Region: PRK05431 407148001084 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 407148001085 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 407148001086 dimer interface [polypeptide binding]; other site 407148001087 active site 407148001088 motif 1; other site 407148001089 motif 2; other site 407148001090 motif 3; other site 407148001091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 407148001092 binding surface 407148001093 TPR motif; other site 407148001094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 407148001095 TPR motif; other site 407148001096 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 407148001097 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 407148001098 domain interfaces; other site 407148001099 active site 407148001100 Predicted dehydrogenase [General function prediction only]; Region: COG0579 407148001101 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 407148001102 pantothenate kinase; Reviewed; Region: PRK13333 407148001103 PQQ-like domain; Region: PQQ_2; pfam13360 407148001104 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 407148001105 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 407148001106 Colicin V production protein; Region: Colicin_V; pfam02674 407148001107 ferric uptake regulator; Provisional; Region: fur; PRK09462 407148001108 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 407148001109 metal binding site 2 [ion binding]; metal-binding site 407148001110 putative DNA binding helix; other site 407148001111 metal binding site 1 [ion binding]; metal-binding site 407148001112 dimer interface [polypeptide binding]; other site 407148001113 structural Zn2+ binding site [ion binding]; other site 407148001114 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 407148001115 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 407148001116 dimer interface [polypeptide binding]; other site 407148001117 putative anticodon binding site; other site 407148001118 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 407148001119 motif 1; other site 407148001120 active site 407148001121 motif 2; other site 407148001122 motif 3; other site 407148001123 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 407148001124 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 407148001125 dimer interface [polypeptide binding]; other site 407148001126 active site 407148001127 glycine-pyridoxal phosphate binding site [chemical binding]; other site 407148001128 folate binding site [chemical binding]; other site 407148001129 Domain of unknown function (DUF1882); Region: DUF1882; pfam08966 407148001130 Sporulation related domain; Region: SPOR; pfam05036 407148001131 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 407148001132 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 407148001133 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 407148001134 shikimate binding site; other site 407148001135 NAD(P) binding site [chemical binding]; other site 407148001136 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 407148001137 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553 407148001138 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 407148001139 Iron-sulfur protein interface; other site 407148001140 proximal heme binding site [chemical binding]; other site 407148001141 distal heme binding site [chemical binding]; other site 407148001142 dimer interface [polypeptide binding]; other site 407148001143 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 407148001144 L-aspartate oxidase; Provisional; Region: PRK06175 407148001145 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 407148001146 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 407148001147 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 407148001148 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 407148001149 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 407148001150 Dynamin family; Region: Dynamin_N; pfam00350 407148001151 G1 box; other site 407148001152 GTP/Mg2+ binding site [chemical binding]; other site 407148001153 G2 box; other site 407148001154 Switch I region; other site 407148001155 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 407148001156 G3 box; other site 407148001157 Switch II region; other site 407148001158 GTP/Mg2+ binding site [chemical binding]; other site 407148001159 G4 box; other site 407148001160 G5 box; other site 407148001161 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 407148001162 Dynamin family; Region: Dynamin_N; pfam00350 407148001163 G1 box; other site 407148001164 GTP/Mg2+ binding site [chemical binding]; other site 407148001165 G2 box; other site 407148001166 Switch I region; other site 407148001167 G3 box; other site 407148001168 Switch II region; other site 407148001169 G4 box; other site 407148001170 G5 box; other site 407148001171 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 407148001172 Sel1-like repeats; Region: SEL1; smart00671 407148001173 Sel1 repeat; Region: Sel1; cl02723 407148001174 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 407148001175 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 407148001176 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 407148001177 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 407148001178 SprA-related family; Region: SprA-related; pfam12118 407148001179 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 407148001180 HIT family signature motif; other site 407148001181 catalytic residue [active] 407148001182 Uncharacterized conserved protein [Function unknown]; Region: COG2353 407148001183 Transposase; Region: HTH_Tnp_1; cl17663 407148001184 TM2 domain; Region: TM2; cl00984 407148001185 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 407148001186 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 407148001187 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 407148001188 ABC transporter; Region: ABC_tran_2; pfam12848 407148001189 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 407148001190 S-layer like family, C-terminal region; Region: S_layer_C; pfam05124 407148001191 Uncharacterized conserved protein [Function unknown]; Region: COG1739 407148001192 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 407148001193 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 407148001194 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 407148001195 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 407148001196 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 407148001197 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 407148001198 Mg++ binding site [ion binding]; other site 407148001199 putative catalytic motif [active] 407148001200 putative substrate binding site [chemical binding]; other site 407148001201 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 407148001202 phosphoglyceromutase; Provisional; Region: PRK05434 407148001203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 407148001204 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 407148001205 NAD(P) binding site [chemical binding]; other site 407148001206 active site 407148001207 Uncharacterized conserved protein [Function unknown]; Region: COG5015 407148001208 L-aspartate oxidase; Provisional; Region: PRK06175 407148001209 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 407148001210 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 407148001211 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 407148001212 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 407148001213 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 407148001214 Cysteine-rich domain; Region: CCG; pfam02754 407148001215 Cysteine-rich domain; Region: CCG; pfam02754 407148001216 Putative transcription activator [Transcription]; Region: TenA; COG0819 407148001217 acyl carrier protein; Provisional; Region: acpP; PRK00982 407148001218 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 407148001219 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 407148001220 dimer interface [polypeptide binding]; other site 407148001221 active site 407148001222 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 407148001223 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 407148001224 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 407148001225 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 407148001226 N-terminal plug; other site 407148001227 ligand-binding site [chemical binding]; other site 407148001228 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 407148001229 dimer interface [polypeptide binding]; other site 407148001230 ADP-ribose binding site [chemical binding]; other site 407148001231 active site 407148001232 nudix motif; other site 407148001233 metal binding site [ion binding]; metal-binding site 407148001234 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 407148001235 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 407148001236 dimer interface [polypeptide binding]; other site 407148001237 putative CheW interface [polypeptide binding]; other site 407148001238 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 407148001239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 407148001240 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 407148001241 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 407148001242 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 407148001243 substrate binding site [chemical binding]; other site 407148001244 hexamer interface [polypeptide binding]; other site 407148001245 metal binding site [ion binding]; metal-binding site 407148001246 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 407148001247 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 407148001248 active site 407148001249 catalytic site [active] 407148001250 substrate binding site [chemical binding]; other site 407148001251 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 407148001252 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 407148001253 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 407148001254 putative acyl-acceptor binding pocket; other site 407148001255 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 407148001256 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 407148001257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 407148001258 FeS/SAM binding site; other site 407148001259 TRAM domain; Region: TRAM; pfam01938 407148001260 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 407148001261 NusA N-terminal domain; Region: NusA_N; pfam08529 407148001262 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 407148001263 RNA binding site [nucleotide binding]; other site 407148001264 homodimer interface [polypeptide binding]; other site 407148001265 NusA-like KH domain; Region: KH_5; pfam13184 407148001266 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 407148001267 G-X-X-G motif; other site 407148001268 H+ Antiporter protein; Region: 2A0121; TIGR00900 407148001269 hypothetical protein; Provisional; Region: PRK08445 407148001270 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 407148001271 FeS/SAM binding site; other site 407148001272 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 407148001273 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 407148001274 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 407148001275 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 407148001276 generic binding surface II; other site 407148001277 ssDNA binding site; other site 407148001278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 407148001279 ATP binding site [chemical binding]; other site 407148001280 putative Mg++ binding site [ion binding]; other site 407148001281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 407148001282 nucleotide binding region [chemical binding]; other site 407148001283 ATP-binding site [chemical binding]; other site 407148001284 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 407148001285 apolar tunnel; other site 407148001286 heme binding site [chemical binding]; other site 407148001287 dimerization interface [polypeptide binding]; other site 407148001288 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 407148001289 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 407148001290 ligand binding site [chemical binding]; other site 407148001291 flexible hinge region; other site 407148001292 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 407148001293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148001294 dimer interface [polypeptide binding]; other site 407148001295 conserved gate region; other site 407148001296 putative PBP binding loops; other site 407148001297 ABC-ATPase subunit interface; other site 407148001298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148001299 dimer interface [polypeptide binding]; other site 407148001300 conserved gate region; other site 407148001301 putative PBP binding loops; other site 407148001302 ABC-ATPase subunit interface; other site 407148001303 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 407148001304 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 407148001305 Walker A/P-loop; other site 407148001306 ATP binding site [chemical binding]; other site 407148001307 Q-loop/lid; other site 407148001308 ABC transporter signature motif; other site 407148001309 Walker B; other site 407148001310 D-loop; other site 407148001311 H-loop/switch region; other site 407148001312 elongation factor Tu; Reviewed; Region: PRK00049 407148001313 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 407148001314 G1 box; other site 407148001315 GEF interaction site [polypeptide binding]; other site 407148001316 GTP/Mg2+ binding site [chemical binding]; other site 407148001317 Switch I region; other site 407148001318 G2 box; other site 407148001319 G3 box; other site 407148001320 Switch II region; other site 407148001321 G4 box; other site 407148001322 G5 box; other site 407148001323 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 407148001324 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 407148001325 Antibiotic Binding Site [chemical binding]; other site 407148001326 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 407148001327 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 407148001328 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 407148001329 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 407148001330 putative homodimer interface [polypeptide binding]; other site 407148001331 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 407148001332 heterodimer interface [polypeptide binding]; other site 407148001333 homodimer interface [polypeptide binding]; other site 407148001334 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 407148001335 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 407148001336 23S rRNA interface [nucleotide binding]; other site 407148001337 L7/L12 interface [polypeptide binding]; other site 407148001338 putative thiostrepton binding site; other site 407148001339 L25 interface [polypeptide binding]; other site 407148001340 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 407148001341 mRNA/rRNA interface [nucleotide binding]; other site 407148001342 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 407148001343 23S rRNA interface [nucleotide binding]; other site 407148001344 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 407148001345 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 407148001346 L11 interface [polypeptide binding]; other site 407148001347 putative EF-Tu interaction site [polypeptide binding]; other site 407148001348 putative EF-G interaction site [polypeptide binding]; other site 407148001349 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 407148001350 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 407148001351 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 407148001352 RPB11 interaction site [polypeptide binding]; other site 407148001353 RPB12 interaction site [polypeptide binding]; other site 407148001354 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 407148001355 RPB3 interaction site [polypeptide binding]; other site 407148001356 RPB1 interaction site [polypeptide binding]; other site 407148001357 RPB11 interaction site [polypeptide binding]; other site 407148001358 RPB10 interaction site [polypeptide binding]; other site 407148001359 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 407148001360 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 407148001361 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 407148001362 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 407148001363 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 407148001364 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 407148001365 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 407148001366 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 407148001367 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 407148001368 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 407148001369 DNA binding site [nucleotide binding] 407148001370 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 407148001371 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 407148001372 S17 interaction site [polypeptide binding]; other site 407148001373 S8 interaction site; other site 407148001374 16S rRNA interaction site [nucleotide binding]; other site 407148001375 streptomycin interaction site [chemical binding]; other site 407148001376 23S rRNA interaction site [nucleotide binding]; other site 407148001377 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 407148001378 30S ribosomal protein S7; Validated; Region: PRK05302 407148001379 elongation factor G; Reviewed; Region: PRK00007 407148001380 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 407148001381 G1 box; other site 407148001382 putative GEF interaction site [polypeptide binding]; other site 407148001383 GTP/Mg2+ binding site [chemical binding]; other site 407148001384 Switch I region; other site 407148001385 G2 box; other site 407148001386 G3 box; other site 407148001387 Switch II region; other site 407148001388 G4 box; other site 407148001389 G5 box; other site 407148001390 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 407148001391 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 407148001392 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 407148001393 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 407148001394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148001395 S-adenosylmethionine binding site [chemical binding]; other site 407148001396 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 407148001397 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 407148001398 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 407148001399 active site 407148001400 substrate (anthranilate) binding pocket [chemical binding]; other site 407148001401 product (indole) binding pocket [chemical binding]; other site 407148001402 ribulose/triose binding site [chemical binding]; other site 407148001403 phosphate binding site [ion binding]; other site 407148001404 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 407148001405 nucleotide binding site/active site [active] 407148001406 HIT family signature motif; other site 407148001407 catalytic residue [active] 407148001408 Predicted ATPase [General function prediction only]; Region: COG2603 407148001409 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 407148001410 active site residue [active] 407148001411 haemagglutination activity domain; Region: Haemagg_act; pfam05860 407148001412 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 407148001413 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 407148001414 Surface antigen; Region: Bac_surface_Ag; pfam01103 407148001415 ferrochelatase; Reviewed; Region: hemH; PRK00035 407148001416 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 407148001417 C-terminal domain interface [polypeptide binding]; other site 407148001418 active site 407148001419 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 407148001420 active site 407148001421 N-terminal domain interface [polypeptide binding]; other site 407148001422 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 407148001423 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 407148001424 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 407148001425 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 407148001426 inhibitor-cofactor binding pocket; inhibition site 407148001427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148001428 catalytic residue [active] 407148001429 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 407148001430 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 407148001431 motif 1; other site 407148001432 active site 407148001433 motif 2; other site 407148001434 motif 3; other site 407148001435 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 407148001436 DHHA1 domain; Region: DHHA1; pfam02272 407148001437 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 407148001438 Maf-like protein; Region: Maf; pfam02545 407148001439 active site 407148001440 dimer interface [polypeptide binding]; other site 407148001441 Transglycosylase; Region: Transgly; pfam00912 407148001442 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 407148001443 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 407148001444 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 407148001445 Clp amino terminal domain; Region: Clp_N; pfam02861 407148001446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148001447 Walker A motif; other site 407148001448 ATP binding site [chemical binding]; other site 407148001449 Walker B motif; other site 407148001450 arginine finger; other site 407148001451 Protein of unknown function (DUF972); Region: DUF972; pfam06156 407148001452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148001453 Walker A motif; other site 407148001454 ATP binding site [chemical binding]; other site 407148001455 Walker B motif; other site 407148001456 arginine finger; other site 407148001457 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 407148001458 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 407148001459 putative homodimer interface [polypeptide binding]; other site 407148001460 putative homotetramer interface [polypeptide binding]; other site 407148001461 putative metal binding site [ion binding]; other site 407148001462 putative homodimer-homodimer interface [polypeptide binding]; other site 407148001463 putative allosteric switch controlling residues; other site 407148001464 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 407148001465 C-terminal peptidase (prc); Region: prc; TIGR00225 407148001466 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 407148001467 protein binding site [polypeptide binding]; other site 407148001468 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 407148001469 Catalytic dyad [active] 407148001470 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 407148001471 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 407148001472 ATP binding site [chemical binding]; other site 407148001473 active site 407148001474 substrate binding site [chemical binding]; other site 407148001475 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 407148001476 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 407148001477 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 407148001478 putative active site [active] 407148001479 catalytic triad [active] 407148001480 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 407148001481 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 407148001482 putative acyl-acceptor binding pocket; other site 407148001483 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 407148001484 heat shock protein 90; Provisional; Region: PRK05218 407148001485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 407148001486 ATP binding site [chemical binding]; other site 407148001487 Mg2+ binding site [ion binding]; other site 407148001488 G-X-G motif; other site 407148001489 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 407148001490 active site residue [active] 407148001491 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 407148001492 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 407148001493 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 407148001494 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 407148001495 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 407148001496 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 407148001497 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK03907 407148001498 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 407148001499 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 407148001500 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 407148001501 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 407148001502 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 407148001503 YceG-like family; Region: YceG; pfam02618 407148001504 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 407148001505 dimerization interface [polypeptide binding]; other site 407148001506 Protein of unknown function; Region: DUF3971; pfam13116 407148001507 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 407148001508 AsmA-like C-terminal region; Region: AsmA_1; pfam13109 407148001509 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 407148001510 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 407148001511 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 407148001512 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 407148001513 NAD(P) binding site [chemical binding]; other site 407148001514 LDH/MDH dimer interface [polypeptide binding]; other site 407148001515 substrate binding site [chemical binding]; other site 407148001516 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 407148001517 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 407148001518 CoA-ligase; Region: Ligase_CoA; pfam00549 407148001519 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 407148001520 CoA binding domain; Region: CoA_binding; smart00881 407148001521 CoA-ligase; Region: Ligase_CoA; pfam00549 407148001522 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 407148001523 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 407148001524 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 407148001525 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 407148001526 dimer interface [polypeptide binding]; other site 407148001527 PYR/PP interface [polypeptide binding]; other site 407148001528 TPP binding site [chemical binding]; other site 407148001529 substrate binding site [chemical binding]; other site 407148001530 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 407148001531 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 407148001532 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 407148001533 TPP-binding site [chemical binding]; other site 407148001534 2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441 407148001535 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 407148001536 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 407148001537 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 407148001538 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 407148001539 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 407148001540 substrate binding pocket [chemical binding]; other site 407148001541 chain length determination region; other site 407148001542 substrate-Mg2+ binding site; other site 407148001543 catalytic residues [active] 407148001544 aspartate-rich region 1; other site 407148001545 active site lid residues [active] 407148001546 aspartate-rich region 2; other site 407148001547 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 407148001548 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 407148001549 tRNA; other site 407148001550 putative tRNA binding site [nucleotide binding]; other site 407148001551 putative NADP binding site [chemical binding]; other site 407148001552 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 407148001553 prolyl-tRNA synthetase; Provisional; Region: PRK09194 407148001554 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 407148001555 dimer interface [polypeptide binding]; other site 407148001556 motif 1; other site 407148001557 active site 407148001558 motif 2; other site 407148001559 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 407148001560 putative deacylase active site [active] 407148001561 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 407148001562 active site 407148001563 motif 3; other site 407148001564 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 407148001565 anticodon binding site; other site 407148001566 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 407148001567 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 407148001568 domain interfaces; other site 407148001569 active site 407148001570 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 407148001571 flagellar protein FlaG; Provisional; Region: PRK08452 407148001572 flagellar capping protein; Provisional; Region: PRK12765 407148001573 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 407148001574 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 407148001575 flagellar protein FliS; Validated; Region: fliS; PRK05685 407148001576 Predicted GTPase [General function prediction only]; Region: Obg; COG0536 407148001577 elongation factor P; Validated; Region: PRK00529 407148001578 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 407148001579 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 407148001580 RNA binding site [nucleotide binding]; other site 407148001581 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 407148001582 RNA binding site [nucleotide binding]; other site 407148001583 Predicted membrane protein [Function unknown]; Region: COG3819 407148001584 Predicted membrane protein [Function unknown]; Region: COG3817 407148001585 Protein of unknown function (DUF979); Region: DUF979; pfam06166 407148001586 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 407148001587 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 407148001588 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 407148001589 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 407148001590 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 407148001591 active site 407148001592 Predicted membrane protein [Function unknown]; Region: COG1289 407148001593 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 407148001594 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 407148001595 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 407148001596 putative catalytic cysteine [active] 407148001597 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 407148001598 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 407148001599 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 407148001600 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 407148001601 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 407148001602 Protein of unknown function (DUF2860); Region: DUF2860; pfam11059 407148001603 replicative DNA helicase; Provisional; Region: PRK08506 407148001604 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 407148001605 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 407148001606 Walker A motif; other site 407148001607 ATP binding site [chemical binding]; other site 407148001608 Walker B motif; other site 407148001609 DNA binding loops [nucleotide binding] 407148001610 Predicted transcriptional regulator [Transcription]; Region: COG2378 407148001611 HTH domain; Region: HTH_11; pfam08279 407148001612 WYL domain; Region: WYL; pfam13280 407148001613 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 407148001614 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 407148001615 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 407148001616 Uncharacterized conserved protein [Function unknown]; Region: COG1610 407148001617 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527 407148001618 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 407148001619 PYR/PP interface [polypeptide binding]; other site 407148001620 dimer interface [polypeptide binding]; other site 407148001621 TPP binding site [chemical binding]; other site 407148001622 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 407148001623 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 407148001624 TPP-binding site [chemical binding]; other site 407148001625 dimer interface [polypeptide binding]; other site 407148001626 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 407148001627 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 407148001628 putative valine binding site [chemical binding]; other site 407148001629 dimer interface [polypeptide binding]; other site 407148001630 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 407148001631 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 407148001632 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 407148001633 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 407148001634 trimer interface [polypeptide binding]; other site 407148001635 active site 407148001636 UDP-GlcNAc binding site [chemical binding]; other site 407148001637 lipid binding site [chemical binding]; lipid-binding site 407148001638 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 407148001639 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 407148001640 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 407148001641 sec-independent translocase; Provisional; Region: PRK04098 407148001642 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 407148001643 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 407148001644 putative active site [active] 407148001645 Ap4A binding site [chemical binding]; other site 407148001646 nudix motif; other site 407148001647 putative metal binding site [ion binding]; other site 407148001648 aspartate kinase; Reviewed; Region: PRK06635 407148001649 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 407148001650 putative nucleotide binding site [chemical binding]; other site 407148001651 putative catalytic residues [active] 407148001652 putative Mg ion binding site [ion binding]; other site 407148001653 putative aspartate binding site [chemical binding]; other site 407148001654 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 407148001655 putative allosteric regulatory site; other site 407148001656 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 407148001657 DNA replication regulator; Region: HobA; pfam12163 407148001658 DNA polymerase III subunit delta'; Validated; Region: PRK08485 407148001659 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 407148001660 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 407148001661 substrate binding pocket [chemical binding]; other site 407148001662 dimer interface [polypeptide binding]; other site 407148001663 inhibitor binding site; inhibition site 407148001664 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 407148001665 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 407148001666 nucleotide binding pocket [chemical binding]; other site 407148001667 K-X-D-G motif; other site 407148001668 catalytic site [active] 407148001669 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 407148001670 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 407148001671 Dimer interface [polypeptide binding]; other site 407148001672 BRCT sequence motif; other site 407148001673 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 407148001674 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 407148001675 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 407148001676 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 407148001677 active site 407148001678 nucleotide binding site [chemical binding]; other site 407148001679 HIGH motif; other site 407148001680 KMSKS motif; other site 407148001681 Riboflavin kinase; Region: Flavokinase; pfam01687 407148001682 Methyltransferase domain; Region: Methyltransf_31; pfam13847 407148001683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148001684 S-adenosylmethionine binding site [chemical binding]; other site 407148001685 Predicted membrane protein [Function unknown]; Region: COG2860 407148001686 UPF0126 domain; Region: UPF0126; pfam03458 407148001687 UPF0126 domain; Region: UPF0126; pfam03458 407148001688 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 407148001689 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 407148001690 active site 407148001691 substrate binding site [chemical binding]; other site 407148001692 Mg2+ binding site [ion binding]; other site 407148001693 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 407148001694 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 407148001695 minor groove reading motif; other site 407148001696 helix-hairpin-helix signature motif; other site 407148001697 substrate binding pocket [chemical binding]; other site 407148001698 active site 407148001699 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 407148001700 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 407148001701 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 407148001702 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 407148001703 active site 407148001704 intersubunit interface [polypeptide binding]; other site 407148001705 zinc binding site [ion binding]; other site 407148001706 Na+ binding site [ion binding]; other site 407148001707 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 407148001708 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 407148001709 hypothetical protein; Validated; Region: PRK09039 407148001710 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 407148001711 ligand binding site [chemical binding]; other site 407148001712 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 407148001713 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 407148001714 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 407148001715 catalytic residue [active] 407148001716 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 407148001717 Na2 binding site [ion binding]; other site 407148001718 putative substrate binding site 1 [chemical binding]; other site 407148001719 Na binding site 1 [ion binding]; other site 407148001720 putative substrate binding site 2 [chemical binding]; other site 407148001721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 407148001722 MOSC domain; Region: MOSC; pfam03473 407148001723 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 407148001724 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 407148001725 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 407148001726 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 407148001727 DsbD alpha interface [polypeptide binding]; other site 407148001728 catalytic residues [active] 407148001729 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 407148001730 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 407148001731 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 407148001732 metal binding site [ion binding]; metal-binding site 407148001733 dimer interface [polypeptide binding]; other site 407148001734 macrolide transporter subunit MacA; Provisional; Region: PRK11578 407148001735 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 407148001736 HlyD family secretion protein; Region: HlyD_3; pfam13437 407148001737 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 407148001738 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 407148001739 Walker A/P-loop; other site 407148001740 ATP binding site [chemical binding]; other site 407148001741 Q-loop/lid; other site 407148001742 ABC transporter signature motif; other site 407148001743 Walker B; other site 407148001744 D-loop; other site 407148001745 H-loop/switch region; other site 407148001746 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 407148001747 FtsX-like permease family; Region: FtsX; pfam02687 407148001748 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 407148001749 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 407148001750 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 407148001751 active site 407148001752 oxyanion hole [active] 407148001753 catalytic triad [active] 407148001754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2845 407148001755 active site 407148001756 catalytic triad [active] 407148001757 oxyanion hole [active] 407148001758 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 407148001759 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 407148001760 Ferritin-like domain; Region: Ferritin; pfam00210 407148001761 ferroxidase diiron center [ion binding]; other site 407148001762 PBP superfamily domain; Region: PBP_like_2; cl17296 407148001763 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 407148001764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148001765 dimer interface [polypeptide binding]; other site 407148001766 conserved gate region; other site 407148001767 putative PBP binding loops; other site 407148001768 ABC-ATPase subunit interface; other site 407148001769 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 407148001770 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 407148001771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148001772 dimer interface [polypeptide binding]; other site 407148001773 conserved gate region; other site 407148001774 putative PBP binding loops; other site 407148001775 ABC-ATPase subunit interface; other site 407148001776 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14269 407148001777 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 407148001778 Walker A/P-loop; other site 407148001779 ATP binding site [chemical binding]; other site 407148001780 Q-loop/lid; other site 407148001781 ABC transporter signature motif; other site 407148001782 Walker B; other site 407148001783 D-loop; other site 407148001784 H-loop/switch region; other site 407148001785 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 407148001786 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 407148001787 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 407148001788 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 407148001789 Acylphosphatase; Region: Acylphosphatase; pfam00708 407148001790 HypF finger; Region: zf-HYPF; pfam07503 407148001791 HypF finger; Region: zf-HYPF; pfam07503 407148001792 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 407148001793 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 407148001794 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 407148001795 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 407148001796 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 407148001797 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 407148001798 dimerization interface [polypeptide binding]; other site 407148001799 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 407148001800 ATP binding site [chemical binding]; other site 407148001801 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 407148001802 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 407148001803 Uncharacterized conserved protein [Function unknown]; Region: COG4748 407148001804 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 407148001805 DNA polymerase III subunit delta; Validated; Region: PRK08487 407148001806 Exoribonuclease R [Transcription]; Region: VacB; COG0557 407148001807 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 407148001808 RNB domain; Region: RNB; pfam00773 407148001809 ketol-acid reductoisomerase; Provisional; Region: PRK05479 407148001810 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 407148001811 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 407148001812 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 407148001813 NodB motif; other site 407148001814 putative active site [active] 407148001815 putative catalytic site [active] 407148001816 Zn binding site [ion binding]; other site 407148001817 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 407148001818 DNA protecting protein DprA; Region: dprA; TIGR00732 407148001819 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 407148001820 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 407148001821 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 407148001822 methionine sulfoxide reductase A; Provisional; Region: PRK14054 407148001823 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 407148001824 dimer interface [polypeptide binding]; other site 407148001825 substrate binding site [chemical binding]; other site 407148001826 metal binding sites [ion binding]; metal-binding site 407148001827 adenylate kinase; Reviewed; Region: adk; PRK00279 407148001828 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 407148001829 AMP-binding site [chemical binding]; other site 407148001830 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 407148001831 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 407148001832 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 407148001833 dimer interface [polypeptide binding]; other site 407148001834 anticodon binding site; other site 407148001835 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 407148001836 homodimer interface [polypeptide binding]; other site 407148001837 motif 1; other site 407148001838 active site 407148001839 motif 2; other site 407148001840 GAD domain; Region: GAD; pfam02938 407148001841 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 407148001842 active site 407148001843 motif 3; other site 407148001844 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: pnk; PRK14077 407148001845 ATP-NAD kinase; Region: NAD_kinase; pfam01513 407148001846 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 407148001847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 407148001848 Walker A/P-loop; other site 407148001849 ATP binding site [chemical binding]; other site 407148001850 Q-loop/lid; other site 407148001851 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 407148001852 ABC transporter signature motif; other site 407148001853 Walker B; other site 407148001854 D-loop; other site 407148001855 H-loop/switch region; other site 407148001856 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 407148001857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 407148001858 active site 407148001859 phosphorylation site [posttranslational modification] 407148001860 intermolecular recognition site; other site 407148001861 dimerization interface [polypeptide binding]; other site 407148001862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 407148001863 active site 407148001864 phosphorylation site [posttranslational modification] 407148001865 intermolecular recognition site; other site 407148001866 dimerization interface [polypeptide binding]; other site 407148001867 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 407148001868 metal binding site [ion binding]; metal-binding site 407148001869 active site 407148001870 I-site; other site 407148001871 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 407148001872 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 407148001873 active site 407148001874 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 407148001875 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 407148001876 N-acetyl-D-glucosamine binding site [chemical binding]; other site 407148001877 catalytic residue [active] 407148001878 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 407148001879 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 407148001880 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 407148001881 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 407148001882 Sporulation related domain; Region: SPOR; pfam05036 407148001883 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 407148001884 active site 407148001885 motif I; other site 407148001886 motif II; other site 407148001887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 407148001888 OstA-like protein; Region: OstA; pfam03968 407148001889 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 407148001890 G1 box; other site 407148001891 GTP/Mg2+ binding site [chemical binding]; other site 407148001892 Switch I region; other site 407148001893 G2 box; other site 407148001894 G3 box; other site 407148001895 Switch II region; other site 407148001896 G4 box; other site 407148001897 G5 box; other site 407148001898 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 407148001899 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 407148001900 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 407148001901 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 407148001902 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 407148001903 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 407148001904 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 407148001905 active site 407148001906 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 407148001907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148001908 putative substrate translocation pore; other site 407148001909 POT family; Region: PTR2; cl17359 407148001910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148001911 putative substrate translocation pore; other site 407148001912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148001913 GTPase Era; Reviewed; Region: era; PRK00089 407148001914 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 407148001915 G1 box; other site 407148001916 GTP/Mg2+ binding site [chemical binding]; other site 407148001917 Switch I region; other site 407148001918 G2 box; other site 407148001919 Switch II region; other site 407148001920 G3 box; other site 407148001921 G4 box; other site 407148001922 G5 box; other site 407148001923 KH domain; Region: KH_2; pfam07650 407148001924 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 407148001925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148001926 Walker A motif; other site 407148001927 ATP binding site [chemical binding]; other site 407148001928 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 407148001929 Walker B motif; other site 407148001930 arginine finger; other site 407148001931 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 407148001932 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 407148001933 active site 407148001934 HslU subunit interaction site [polypeptide binding]; other site 407148001935 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 407148001936 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 407148001937 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 407148001938 argininosuccinate synthase; Provisional; Region: PRK13820 407148001939 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 407148001940 ANP binding site [chemical binding]; other site 407148001941 Substrate Binding Site II [chemical binding]; other site 407148001942 Substrate Binding Site I [chemical binding]; other site 407148001943 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis]; Region: COG1188 407148001944 RNA binding surface [nucleotide binding]; other site 407148001945 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 407148001946 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 407148001947 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 407148001948 Walker A/P-loop; other site 407148001949 ATP binding site [chemical binding]; other site 407148001950 Q-loop/lid; other site 407148001951 ABC transporter signature motif; other site 407148001952 Walker B; other site 407148001953 D-loop; other site 407148001954 H-loop/switch region; other site 407148001955 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 407148001956 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 407148001957 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 407148001958 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 407148001959 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 407148001960 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 407148001961 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 407148001962 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 407148001963 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 407148001964 Soluble P-type ATPase [General function prediction only]; Region: COG4087 407148001965 K+-transporting ATPase, c chain; Region: KdpC; cl00944 407148001966 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 407148001967 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 407148001968 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 407148001969 Ligand Binding Site [chemical binding]; other site 407148001970 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 407148001971 GAF domain; Region: GAF_3; pfam13492 407148001972 excinuclease ABC subunit B; Provisional; Region: PRK05298 407148001973 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 407148001974 ATP binding site [chemical binding]; other site 407148001975 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 407148001976 nucleotide binding region [chemical binding]; other site 407148001977 ATP-binding site [chemical binding]; other site 407148001978 Ultra-violet resistance protein B; Region: UvrB; pfam12344 407148001979 primosome assembly protein PriA; Validated; Region: PRK05580 407148001980 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 407148001981 ATP binding site [chemical binding]; other site 407148001982 putative Mg++ binding site [ion binding]; other site 407148001983 helicase superfamily c-terminal domain; Region: HELICc; smart00490 407148001984 ATP-binding site [chemical binding]; other site 407148001985 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 407148001986 active site 407148001987 metal-binding site 407148001988 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 407148001989 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 407148001990 conserved cys residue [active] 407148001991 hypothetical protein; Provisional; Region: PRK05849 407148001992 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 407148001993 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 407148001994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148001995 S-adenosylmethionine binding site [chemical binding]; other site 407148001996 Methyltransferase domain; Region: Methyltransf_31; pfam13847 407148001997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148001998 S-adenosylmethionine binding site [chemical binding]; other site 407148001999 Predicted transcriptional regulator [Transcription]; Region: COG2932 407148002000 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 407148002001 Catalytic site [active] 407148002002 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 407148002003 Domain of unknown function (DUF955); Region: DUF955; pfam06114 407148002004 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 407148002005 Predicted transcriptional regulator [Transcription]; Region: COG2932 407148002006 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 407148002007 Catalytic site [active] 407148002008 Protein of unknown function (DUF2972); Region: DUF2972; pfam11186 407148002009 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 407148002010 AAA domain; Region: AAA_18; pfam13238 407148002011 ligand-binding site [chemical binding]; other site 407148002012 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 407148002013 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 407148002014 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 407148002015 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 407148002016 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 407148002017 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 407148002018 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 407148002019 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 407148002020 propionate/acetate kinase; Provisional; Region: PRK12379 407148002021 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 407148002022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148002023 S-adenosylmethionine binding site [chemical binding]; other site 407148002024 SurA N-terminal domain; Region: SurA_N_3; cl07813 407148002025 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 407148002026 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 407148002027 cell division protein FtsA; Region: ftsA; TIGR01174 407148002028 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 407148002029 nucleotide binding site [chemical binding]; other site 407148002030 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 407148002031 Cell division protein FtsA; Region: FtsA; pfam14450 407148002032 cell division protein FtsZ; Validated; Region: PRK09330 407148002033 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 407148002034 nucleotide binding site [chemical binding]; other site 407148002035 SulA interaction site; other site 407148002036 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 407148002037 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 407148002038 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 407148002039 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 407148002040 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 407148002041 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 407148002042 glutamine synthetase, type I; Region: GlnA; TIGR00653 407148002043 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 407148002044 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 407148002045 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 407148002046 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 407148002047 Peptidase family U32; Region: Peptidase_U32; pfam01136 407148002048 AIR carboxylase; Region: AIRC; smart01001 407148002049 Protein of unknown function (DUF3972); Region: DUF3972; pfam13118 407148002050 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 407148002051 dimer interface [polypeptide binding]; other site 407148002052 motif 1; other site 407148002053 active site 407148002054 motif 2; other site 407148002055 motif 3; other site 407148002056 Uncharacterized conserved protein [Function unknown]; Region: COG0327 407148002057 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 407148002058 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 407148002059 Putative zinc ribbon domain; Region: DUF164; pfam02591 407148002060 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 407148002061 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 407148002062 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 407148002063 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 407148002064 active site 407148002065 signal recognition particle protein; Provisional; Region: PRK10867 407148002066 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 407148002067 P loop; other site 407148002068 GTP binding site [chemical binding]; other site 407148002069 Signal peptide binding domain; Region: SRP_SPB; pfam02978 407148002070 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 407148002071 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 407148002072 KH domain; Region: KH_4; pfam13083 407148002073 G-X-X-G motif; other site 407148002074 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 407148002075 RimM N-terminal domain; Region: RimM; pfam01782 407148002076 PRC-barrel domain; Region: PRC; pfam05239 407148002077 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 407148002078 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 407148002079 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 407148002080 active site 407148002081 homotetramer interface [polypeptide binding]; other site 407148002082 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 407148002083 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 407148002084 ArsC family; Region: ArsC; pfam03960 407148002085 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 407148002086 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 407148002087 active site 407148002088 PHP Thumb interface [polypeptide binding]; other site 407148002089 metal binding site [ion binding]; metal-binding site 407148002090 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 407148002091 generic binding surface I; other site 407148002092 generic binding surface II; other site 407148002093 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 407148002094 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 407148002095 catalytic residue [active] 407148002096 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 407148002097 flagellin; Provisional; Region: PRK12804 407148002098 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 407148002099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148002100 S-adenosylmethionine binding site [chemical binding]; other site 407148002101 Peptidase family M48; Region: Peptidase_M48; pfam01435 407148002102 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 407148002103 MPT binding site; other site 407148002104 trimer interface [polypeptide binding]; other site 407148002105 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 407148002106 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 407148002107 oligomer interface [polypeptide binding]; other site 407148002108 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 407148002109 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 407148002110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 407148002111 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 407148002112 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4132 407148002113 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 407148002114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148002115 dimer interface [polypeptide binding]; other site 407148002116 conserved gate region; other site 407148002117 putative PBP binding loops; other site 407148002118 ABC-ATPase subunit interface; other site 407148002119 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 407148002120 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 407148002121 Walker A/P-loop; other site 407148002122 ATP binding site [chemical binding]; other site 407148002123 Q-loop/lid; other site 407148002124 ABC transporter signature motif; other site 407148002125 Walker B; other site 407148002126 D-loop; other site 407148002127 H-loop/switch region; other site 407148002128 TOBE domain; Region: TOBE_2; pfam08402 407148002129 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 407148002130 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 407148002131 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 407148002132 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 407148002133 substrate binding pocket [chemical binding]; other site 407148002134 membrane-bound complex binding site; other site 407148002135 hinge residues; other site 407148002136 haemagglutination activity domain; Region: Haemagg_act; smart00912 407148002137 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 407148002138 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 407148002139 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 407148002140 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 407148002141 heat-inducible transcription repressor; Provisional; Region: PRK03911 407148002142 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 407148002143 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 407148002144 dimer interface [polypeptide binding]; other site 407148002145 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 407148002146 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 407148002147 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 407148002148 nucleotide binding site [chemical binding]; other site 407148002149 NEF interaction site [polypeptide binding]; other site 407148002150 SBD interface [polypeptide binding]; other site 407148002151 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 407148002152 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 407148002153 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 407148002154 aspartate aminotransferase; Provisional; Region: PRK05764 407148002155 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 407148002156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148002157 homodimer interface [polypeptide binding]; other site 407148002158 catalytic residue [active] 407148002159 serine O-acetyltransferase; Region: cysE; TIGR01172 407148002160 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 407148002161 trimer interface [polypeptide binding]; other site 407148002162 active site 407148002163 substrate binding site [chemical binding]; other site 407148002164 CoA binding site [chemical binding]; other site 407148002165 arginine decarboxylase; Provisional; Region: PRK05354 407148002166 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 407148002167 dimer interface [polypeptide binding]; other site 407148002168 active site 407148002169 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 407148002170 catalytic residues [active] 407148002171 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 407148002172 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 407148002173 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 407148002174 dimer interface [polypeptide binding]; other site 407148002175 motif 1; other site 407148002176 active site 407148002177 motif 2; other site 407148002178 motif 3; other site 407148002179 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 407148002180 anticodon binding site; other site 407148002181 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 407148002182 thymidylate kinase; Validated; Region: tmk; PRK00698 407148002183 TMP-binding site; other site 407148002184 ATP-binding site [chemical binding]; other site 407148002185 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 407148002186 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 407148002187 active site 407148002188 (T/H)XGH motif; other site 407148002189 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 407148002190 Flavoprotein; Region: Flavoprotein; pfam02441 407148002191 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515 407148002192 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 407148002193 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 407148002194 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 407148002195 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 407148002196 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 407148002197 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 407148002198 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 407148002199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148002200 ABC-ATPase subunit interface; other site 407148002201 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 407148002202 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 407148002203 Walker A/P-loop; other site 407148002204 ATP binding site [chemical binding]; other site 407148002205 Q-loop/lid; other site 407148002206 ABC transporter signature motif; other site 407148002207 Walker B; other site 407148002208 D-loop; other site 407148002209 H-loop/switch region; other site 407148002210 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 407148002211 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 407148002212 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 407148002213 active site 407148002214 HIGH motif; other site 407148002215 nucleotide binding site [chemical binding]; other site 407148002216 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 407148002217 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 407148002218 active site 407148002219 KMSKS motif; other site 407148002220 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 407148002221 tRNA binding surface [nucleotide binding]; other site 407148002222 anticodon binding site; other site 407148002223 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 407148002224 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 407148002225 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 407148002226 Part of AAA domain; Region: AAA_19; pfam13245 407148002227 Family description; Region: UvrD_C_2; pfam13538 407148002228 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 407148002229 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 407148002230 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 407148002231 dimer interface [polypeptide binding]; other site 407148002232 catalytic triad [active] 407148002233 peroxidatic and resolving cysteines [active] 407148002234 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 407148002235 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 407148002236 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 407148002237 molybdopterin cofactor binding site; other site 407148002238 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 407148002239 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 407148002240 molybdopterin cofactor binding site; other site 407148002241 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 407148002242 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 407148002243 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 407148002244 4Fe-4S binding domain; Region: Fer4_5; pfam12801 407148002245 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 407148002246 Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043 407148002247 FOG: WD40 repeat [General function prediction only]; Region: COG2319 407148002248 NapD protein; Region: NapD; cl01163 407148002249 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 407148002250 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 407148002251 active site 407148002252 NTP binding site [chemical binding]; other site 407148002253 metal binding triad [ion binding]; metal-binding site 407148002254 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 407148002255 Formyltetrahydrofolate hydrolase [Nucleotide transport and metabolism]; Region: PurU; COG0788 407148002256 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 407148002257 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 407148002258 putative active site [active] 407148002259 putative substrate binding site [chemical binding]; other site 407148002260 putative cosubstrate binding site; other site 407148002261 catalytic site [active] 407148002262 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 407148002263 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 407148002264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 407148002265 catalytic residue [active] 407148002266 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 407148002267 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 407148002268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 407148002269 dimer interface [polypeptide binding]; other site 407148002270 phosphorylation site [posttranslational modification] 407148002271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 407148002272 ATP binding site [chemical binding]; other site 407148002273 Mg2+ binding site [ion binding]; other site 407148002274 G-X-G motif; other site 407148002275 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 407148002276 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 407148002277 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 407148002278 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 407148002279 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 407148002280 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 407148002281 ATP-grasp domain; Region: ATP-grasp_4; cl17255 407148002282 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14601 407148002283 RuvA N terminal domain; Region: RuvA_N; pfam01330 407148002284 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 407148002285 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 407148002286 Protein of unknown function (DUF342); Region: DUF342; pfam03961 407148002287 integral membrane protein MviN; Region: mviN; TIGR01695 407148002288 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 407148002289 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 407148002290 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 407148002291 active site 407148002292 HIGH motif; other site 407148002293 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 407148002294 KMSKS motif; other site 407148002295 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 407148002296 tRNA binding surface [nucleotide binding]; other site 407148002297 anticodon binding site; other site 407148002298 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 407148002299 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 407148002300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 407148002301 Walker A/P-loop; other site 407148002302 ATP binding site [chemical binding]; other site 407148002303 Q-loop/lid; other site 407148002304 ABC transporter signature motif; other site 407148002305 Walker B; other site 407148002306 D-loop; other site 407148002307 H-loop/switch region; other site 407148002308 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 407148002309 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 407148002310 quinone interaction residues [chemical binding]; other site 407148002311 active site 407148002312 catalytic residues [active] 407148002313 FMN binding site [chemical binding]; other site 407148002314 substrate binding site [chemical binding]; other site 407148002315 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 407148002316 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 407148002317 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 407148002318 dihydrodipicolinate synthase; Region: dapA; TIGR00674 407148002319 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 407148002320 dimer interface [polypeptide binding]; other site 407148002321 active site 407148002322 catalytic residue [active] 407148002323 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 407148002324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 407148002325 NAD(P) binding site [chemical binding]; other site 407148002326 active site 407148002327 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 407148002328 NAD synthetase; Provisional; Region: PRK13980 407148002329 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 407148002330 homodimer interface [polypeptide binding]; other site 407148002331 NAD binding pocket [chemical binding]; other site 407148002332 ATP binding pocket [chemical binding]; other site 407148002333 Mg binding site [ion binding]; other site 407148002334 active-site loop [active] 407148002335 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 407148002336 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 407148002337 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 407148002338 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 407148002339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148002340 catalytic residue [active] 407148002341 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 407148002342 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 407148002343 Ligand binding site; other site 407148002344 oligomer interface; other site 407148002345 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 407148002346 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 407148002347 substrate binding pocket [chemical binding]; other site 407148002348 membrane-bound complex binding site; other site 407148002349 hinge residues; other site 407148002350 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 407148002351 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 407148002352 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 407148002353 Substrate binding site; other site 407148002354 Mg++ binding site; other site 407148002355 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 407148002356 active site 407148002357 substrate binding site [chemical binding]; other site 407148002358 CoA binding site [chemical binding]; other site 407148002359 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 407148002360 Flavoprotein; Region: Flavoprotein; pfam02441 407148002361 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 407148002362 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 407148002363 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 407148002364 catalytic residue [active] 407148002365 putative FPP diphosphate binding site; other site 407148002366 putative FPP binding hydrophobic cleft; other site 407148002367 dimer interface [polypeptide binding]; other site 407148002368 putative IPP diphosphate binding site; other site 407148002369 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 407148002370 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 407148002371 Predicted permeases [General function prediction only]; Region: COG0795 407148002372 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 407148002373 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 407148002374 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 407148002375 dimerization interface 3.5A [polypeptide binding]; other site 407148002376 active site 407148002377 threonine dehydratase; Provisional; Region: PRK08526 407148002378 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 407148002379 tetramer interface [polypeptide binding]; other site 407148002380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148002381 catalytic residue [active] 407148002382 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 407148002383 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 407148002384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 407148002385 tRNA (Uracil-5-)-methyltransferase; Region: tRNA_U5-meth_tr; pfam05958 407148002386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148002387 S-adenosylmethionine binding site [chemical binding]; other site 407148002388 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 407148002389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 407148002390 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 407148002391 NAD(P) binding site [chemical binding]; other site 407148002392 active site 407148002393 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 407148002394 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 407148002395 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 407148002396 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 407148002397 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 407148002398 substrate binding site [chemical binding]; other site 407148002399 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 407148002400 substrate binding site [chemical binding]; other site 407148002401 ligand binding site [chemical binding]; other site 407148002402 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 407148002403 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 407148002404 DNA binding site [nucleotide binding] 407148002405 active site 407148002406 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 407148002407 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 407148002408 active site 407148002409 HIGH motif; other site 407148002410 KMSKS motif; other site 407148002411 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 407148002412 tRNA binding surface [nucleotide binding]; other site 407148002413 anticodon binding site; other site 407148002414 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 407148002415 putative tRNA-binding site [nucleotide binding]; other site 407148002416 dimer interface [polypeptide binding]; other site 407148002417 Fructose-1,6-bisphosphatase [Carbohydrate transport and metabolism]; Region: Fbp; COG0158 407148002418 active site 407148002419 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 407148002420 Walker A motif; other site 407148002421 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 407148002422 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 407148002423 N-acetyl-D-glucosamine binding site [chemical binding]; other site 407148002424 catalytic residue [active] 407148002425 YGGT family; Region: YGGT; pfam02325 407148002426 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 407148002427 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 407148002428 active site 407148002429 HIGH motif; other site 407148002430 nucleotide binding site [chemical binding]; other site 407148002431 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 407148002432 active site 407148002433 KMSKS motif; other site 407148002434 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 407148002435 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 407148002436 putative active site [active] 407148002437 putative metal binding site [ion binding]; other site 407148002438 phosphatidylserine decarboxylase; Provisional; Region: PRK03934 407148002439 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 407148002440 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 407148002441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148002442 putative substrate translocation pore; other site 407148002443 Major Facilitator Superfamily; Region: MFS_1; pfam07690 407148002444 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 407148002445 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 407148002446 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 407148002447 inhibitor-cofactor binding pocket; inhibition site 407148002448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148002449 catalytic residue [active] 407148002450 ubiquitin-activating enzyme E1; Region: Ube1; TIGR01408 407148002451 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14166 407148002452 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 407148002453 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 407148002454 homodimer interface [polypeptide binding]; other site 407148002455 NADP binding site [chemical binding]; other site 407148002456 substrate binding site [chemical binding]; other site 407148002457 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 407148002458 Catalytic site [active] 407148002459 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 407148002460 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 407148002461 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 407148002462 dimer interface [polypeptide binding]; other site 407148002463 putative functional site; other site 407148002464 putative MPT binding site; other site 407148002465 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 407148002466 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 407148002467 hinge; other site 407148002468 active site 407148002469 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 407148002470 EamA-like transporter family; Region: EamA; pfam00892 407148002471 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 407148002472 Glutamine amidotransferase class-I; Region: GATase; pfam00117 407148002473 glutamine binding [chemical binding]; other site 407148002474 catalytic triad [active] 407148002475 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 407148002476 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 407148002477 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 407148002478 substrate-cofactor binding pocket; other site 407148002479 homodimer interface [polypeptide binding]; other site 407148002480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148002481 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 407148002482 catalytic residue [active] 407148002483 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 407148002484 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 407148002485 active site 407148002486 DNA binding site [nucleotide binding] 407148002487 Int/Topo IB signature motif; other site 407148002488 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 407148002489 catalytic residues [active] 407148002490 hinge region; other site 407148002491 alpha helical domain; other site 407148002492 putative disulfide oxidoreductase; Provisional; Region: PRK04307 407148002493 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 407148002494 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 407148002495 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 407148002496 catalytic residues [active] 407148002497 hinge region; other site 407148002498 alpha helical domain; other site 407148002499 Cytochrome c [Energy production and conversion]; Region: COG3258 407148002500 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 407148002501 DHH family; Region: DHH; pfam01368 407148002502 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 407148002503 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 407148002504 FHIPEP family; Region: FHIPEP; pfam00771 407148002505 Rrf2 family protein; Region: rrf2_super; TIGR00738 407148002506 Transcriptional regulator; Region: Rrf2; pfam02082 407148002507 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 407148002508 16S/18S rRNA binding site [nucleotide binding]; other site 407148002509 S13e-L30e interaction site [polypeptide binding]; other site 407148002510 25S rRNA binding site [nucleotide binding]; other site 407148002511 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 407148002512 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 407148002513 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 407148002514 lagellar hook-associated protein FlgL; Provisional; Region: PRK14692 407148002515 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 407148002516 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 407148002517 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 407148002518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 407148002519 Walker A/P-loop; other site 407148002520 ATP binding site [chemical binding]; other site 407148002521 Q-loop/lid; other site 407148002522 ABC transporter signature motif; other site 407148002523 Walker B; other site 407148002524 D-loop; other site 407148002525 H-loop/switch region; other site 407148002526 ABC transporter; Region: ABC_tran_2; pfam12848 407148002527 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 407148002528 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 407148002529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 407148002530 ATP binding site [chemical binding]; other site 407148002531 Mg2+ binding site [ion binding]; other site 407148002532 G-X-G motif; other site 407148002533 two-component response regulator; Provisional; Region: PRK11173 407148002534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 407148002535 active site 407148002536 phosphorylation site [posttranslational modification] 407148002537 intermolecular recognition site; other site 407148002538 dimerization interface [polypeptide binding]; other site 407148002539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 407148002540 DNA binding site [nucleotide binding] 407148002541 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 407148002542 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 407148002543 ligand binding site [chemical binding]; other site 407148002544 NAD binding site [chemical binding]; other site 407148002545 dimerization interface [polypeptide binding]; other site 407148002546 catalytic site [active] 407148002547 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 407148002548 putative L-serine binding site [chemical binding]; other site 407148002549 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 407148002550 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 407148002551 RNA binding site [nucleotide binding]; other site 407148002552 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 407148002553 RNA binding site [nucleotide binding]; other site 407148002554 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 407148002555 RNA binding site [nucleotide binding]; other site 407148002556 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 407148002557 RNA binding site [nucleotide binding]; other site 407148002558 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 407148002559 RNA binding site [nucleotide binding]; other site 407148002560 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 407148002561 RNA binding site [nucleotide binding]; other site 407148002562 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 407148002563 LytB protein; Region: LYTB; pfam02401 407148002564 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 407148002565 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 407148002566 hinge; other site 407148002567 active site 407148002568 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 407148002569 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 407148002570 putative tRNA-binding site [nucleotide binding]; other site 407148002571 B3/4 domain; Region: B3_4; pfam03483 407148002572 tRNA synthetase B5 domain; Region: B5; smart00874 407148002573 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 407148002574 dimer interface [polypeptide binding]; other site 407148002575 motif 1; other site 407148002576 motif 3; other site 407148002577 motif 2; other site 407148002578 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 407148002579 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 407148002580 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 407148002581 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 407148002582 dimer interface [polypeptide binding]; other site 407148002583 motif 1; other site 407148002584 active site 407148002585 motif 2; other site 407148002586 motif 3; other site 407148002587 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 407148002588 nucleotide binding site/active site [active] 407148002589 HIT family signature motif; other site 407148002590 catalytic residue [active] 407148002591 DJ-1 family protein; Region: not_thiJ; TIGR01383 407148002592 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 407148002593 conserved cys residue [active] 407148002594 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 407148002595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148002596 dimer interface [polypeptide binding]; other site 407148002597 conserved gate region; other site 407148002598 putative PBP binding loops; other site 407148002599 ABC-ATPase subunit interface; other site 407148002600 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 407148002601 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 407148002602 Walker A/P-loop; other site 407148002603 ATP binding site [chemical binding]; other site 407148002604 Q-loop/lid; other site 407148002605 ABC transporter signature motif; other site 407148002606 Walker B; other site 407148002607 D-loop; other site 407148002608 H-loop/switch region; other site 407148002609 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 407148002610 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 407148002611 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 407148002612 alanine racemase; Reviewed; Region: alr; PRK00053 407148002613 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 407148002614 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 407148002615 catalytic residue [active] 407148002616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 407148002617 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 407148002618 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 407148002619 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 407148002620 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 407148002621 Cu(I) binding site [ion binding]; other site 407148002622 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 407148002623 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 407148002624 dimer interface [polypeptide binding]; other site 407148002625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148002626 catalytic residue [active] 407148002627 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 407148002628 IHF dimer interface [polypeptide binding]; other site 407148002629 IHF - DNA interface [nucleotide binding]; other site 407148002630 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 407148002631 Protein of unknown function (DUF466); Region: DUF466; cl01082 407148002632 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 407148002633 Carbon starvation protein CstA; Region: CstA; pfam02554 407148002634 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 407148002635 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 407148002636 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 407148002637 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 407148002638 active site 407148002639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148002640 dimer interface [polypeptide binding]; other site 407148002641 conserved gate region; other site 407148002642 putative PBP binding loops; other site 407148002643 ABC-ATPase subunit interface; other site 407148002644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148002645 dimer interface [polypeptide binding]; other site 407148002646 conserved gate region; other site 407148002647 putative PBP binding loops; other site 407148002648 ABC-ATPase subunit interface; other site 407148002649 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 407148002650 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 407148002651 substrate binding pocket [chemical binding]; other site 407148002652 membrane-bound complex binding site; other site 407148002653 hinge residues; other site 407148002654 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 407148002655 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 407148002656 Walker A/P-loop; other site 407148002657 ATP binding site [chemical binding]; other site 407148002658 Q-loop/lid; other site 407148002659 ABC transporter signature motif; other site 407148002660 Walker B; other site 407148002661 D-loop; other site 407148002662 H-loop/switch region; other site 407148002663 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 407148002664 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 407148002665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148002666 S-adenosylmethionine binding site [chemical binding]; other site 407148002667 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 407148002668 CheB methylesterase; Region: CheB_methylest; pfam01339 407148002669 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 407148002670 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 407148002671 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 407148002672 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 407148002673 active site 407148002674 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 407148002675 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 407148002676 multifunctional aminopeptidase A; Provisional; Region: PRK00913 407148002677 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 407148002678 interface (dimer of trimers) [polypeptide binding]; other site 407148002679 Substrate-binding/catalytic site; other site 407148002680 Zn-binding sites [ion binding]; other site 407148002681 GTP-binding protein YchF; Reviewed; Region: PRK09601 407148002682 YchF GTPase; Region: YchF; cd01900 407148002683 G1 box; other site 407148002684 GTP/Mg2+ binding site [chemical binding]; other site 407148002685 Switch I region; other site 407148002686 G2 box; other site 407148002687 Switch II region; other site 407148002688 G3 box; other site 407148002689 G4 box; other site 407148002690 G5 box; other site 407148002691 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 407148002692 argininosuccinate lyase; Provisional; Region: PRK00855 407148002693 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 407148002694 active sites [active] 407148002695 tetramer interface [polypeptide binding]; other site 407148002696 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 407148002697 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 407148002698 active site 407148002699 substrate-binding site [chemical binding]; other site 407148002700 metal-binding site [ion binding] 407148002701 ATP binding site [chemical binding]; other site 407148002702 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 407148002703 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 407148002704 active site 407148002705 catalytic residues [active] 407148002706 metal binding site [ion binding]; metal-binding site 407148002707 homodimer binding site [polypeptide binding]; other site 407148002708 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 407148002709 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 407148002710 carboxyltransferase (CT) interaction site; other site 407148002711 biotinylation site [posttranslational modification]; other site 407148002712 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 407148002713 Na2 binding site [ion binding]; other site 407148002714 putative substrate binding site 1 [chemical binding]; other site 407148002715 Na binding site 1 [ion binding]; other site 407148002716 putative substrate binding site 2 [chemical binding]; other site 407148002717 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 407148002718 Na2 binding site [ion binding]; other site 407148002719 putative substrate binding site 1 [chemical binding]; other site 407148002720 Na binding site 1 [ion binding]; other site 407148002721 putative substrate binding site 2 [chemical binding]; other site 407148002722 F0F1 ATP synthase subunit C; Validated; Region: PRK08482 407148002723 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 407148002724 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 407148002725 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 407148002726 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 407148002727 Predicted permeases [General function prediction only]; Region: COG0679 407148002728 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 407148002729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148002730 putative substrate translocation pore; other site 407148002731 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 407148002732 putative acyl-acceptor binding pocket; other site 407148002733 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 407148002734 acyl-activating enzyme (AAE) consensus motif; other site 407148002735 AMP binding site [chemical binding]; other site 407148002736 active site 407148002737 CoA binding site [chemical binding]; other site 407148002738 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 407148002739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148002740 dimer interface [polypeptide binding]; other site 407148002741 conserved gate region; other site 407148002742 putative PBP binding loops; other site 407148002743 ABC-ATPase subunit interface; other site 407148002744 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 407148002745 FtsX-like permease family; Region: FtsX; pfam02687 407148002746 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 407148002747 DEAD/DEAH box helicase; Region: DEAD; pfam00270 407148002748 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 407148002749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 407148002750 nucleotide binding region [chemical binding]; other site 407148002751 ATP-binding site [chemical binding]; other site 407148002752 SEC-C motif; Region: SEC-C; pfam02810 407148002753 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 407148002754 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 407148002755 PIF1-like helicase; Region: PIF1; pfam05970 407148002756 Helicase; Region: Herpes_Helicase; pfam02689 407148002757 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 407148002758 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 407148002759 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 407148002760 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 407148002761 NlpC/P60 family; Region: NLPC_P60; cl17555 407148002762 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 407148002763 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 407148002764 putative active site; other site 407148002765 catalytic triad [active] 407148002766 putative dimer interface [polypeptide binding]; other site 407148002767 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 407148002768 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 407148002769 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957 407148002770 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 407148002771 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 407148002772 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 407148002773 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 407148002774 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 407148002775 dimer interface [polypeptide binding]; other site 407148002776 putative CheW interface [polypeptide binding]; other site 407148002777 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 407148002778 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 407148002779 purine monophosphate binding site [chemical binding]; other site 407148002780 dimer interface [polypeptide binding]; other site 407148002781 putative catalytic residues [active] 407148002782 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 407148002783 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 407148002784 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 407148002785 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 407148002786 putative metal binding site [ion binding]; other site 407148002787 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 407148002788 HSP70 interaction site [polypeptide binding]; other site 407148002789 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 407148002790 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 407148002791 dimerization interface [polypeptide binding]; other site 407148002792 ATP binding site [chemical binding]; other site 407148002793 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 407148002794 dimerization interface [polypeptide binding]; other site 407148002795 ATP binding site [chemical binding]; other site 407148002796 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 407148002797 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 407148002798 trmE is a tRNA modification GTPase; Region: trmE; cd04164 407148002799 G1 box; other site 407148002800 GTP/Mg2+ binding site [chemical binding]; other site 407148002801 Switch I region; other site 407148002802 G2 box; other site 407148002803 Switch II region; other site 407148002804 G3 box; other site 407148002805 G4 box; other site 407148002806 G5 box; other site 407148002807 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 407148002808 membrane protein insertase; Provisional; Region: PRK01318 407148002809 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 407148002810 Uncharacterized conserved protein [Function unknown]; Region: COG0759 407148002811 RNase P protein component [Translation, ribosomal structure and biogenesis]; Region: RnpA; COG0594 407148002812 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 407148002813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 407148002814 Coenzyme A binding pocket [chemical binding]; other site 407148002815 Uracil-DNA glycosylase [DNA replication, recombination, and repair]; Region: COG1573 407148002816 ligand binding site [chemical binding]; other site 407148002817 active site 407148002818 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 407148002819 active site 407148002820 haemagglutination activity domain; Region: Haemagg_act; pfam05860 407148002821 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 407148002822 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 407148002823 Surface antigen; Region: Bac_surface_Ag; pfam01103 407148002824 Hemerythrin; Region: Hemerythrin; cd12107 407148002825 Fe binding site [ion binding]; other site 407148002826 Hemerythrin; Region: Hemerythrin; cd12107 407148002827 Hemerythrin family; Region: Hemerythrin-like; cl15774 407148002828 Methyltransferase domain; Region: Methyltransf_23; pfam13489 407148002829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148002830 S-adenosylmethionine binding site [chemical binding]; other site 407148002831 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 407148002832 active site 1 [active] 407148002833 active site 2 [active] 407148002834 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 407148002835 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 407148002836 Catalytic site; other site 407148002837 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 407148002838 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 407148002839 metal binding site [ion binding]; metal-binding site 407148002840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148002841 metabolite-proton symporter; Region: 2A0106; TIGR00883 407148002842 putative substrate translocation pore; other site 407148002843 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 407148002844 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 407148002845 substrate binding pocket [chemical binding]; other site 407148002846 membrane-bound complex binding site; other site 407148002847 hinge residues; other site 407148002848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3022 407148002849 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 407148002850 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 407148002851 metal binding site [ion binding]; metal-binding site 407148002852 putative dimer interface [polypeptide binding]; other site 407148002853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148002854 Major Facilitator Superfamily; Region: MFS_1; pfam07690 407148002855 putative substrate translocation pore; other site 407148002856 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 407148002857 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 407148002858 Cysteine-rich domain; Region: CCG; pfam02754 407148002859 Cysteine-rich domain; Region: CCG; pfam02754 407148002860 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 407148002861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 407148002862 FeS/SAM binding site; other site 407148002863 HemN C-terminal domain; Region: HemN_C; pfam06969 407148002864 Protein of unknown function (DUF2603); Region: DUF2603; pfam10788 407148002865 ornithine carbamoyltransferase; Provisional; Region: PRK00779 407148002866 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 407148002867 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 407148002868 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 407148002869 dimer interface [polypeptide binding]; other site 407148002870 active site 407148002871 Schiff base residues; other site 407148002872 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 407148002873 dimerization interface [polypeptide binding]; other site 407148002874 active site 407148002875 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 407148002876 16S rRNA (guanine(527)-N(7))-methyltransferase GidB; Region: gidB; TIGR00138 407148002877 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 407148002878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 407148002879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 407148002880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 407148002881 dimerization interface [polypeptide binding]; other site 407148002882 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 407148002883 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 407148002884 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 407148002885 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 407148002886 DNA binding residues [nucleotide binding] 407148002887 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 407148002888 catalytic core [active] 407148002889 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 407148002890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148002891 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 407148002892 Walker A motif; other site 407148002893 ATP binding site [chemical binding]; other site 407148002894 Walker B motif; other site 407148002895 arginine finger; other site 407148002896 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 407148002897 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 407148002898 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 407148002899 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 407148002900 Mechanosensitive ion channel; Region: MS_channel; pfam00924 407148002901 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 407148002902 active site 407148002903 dimer interface [polypeptide binding]; other site 407148002904 metal binding site [ion binding]; metal-binding site 407148002905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 407148002906 TrkA-C domain; Region: TrkA_C; pfam02080 407148002907 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 407148002908 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 407148002909 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 407148002910 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 407148002911 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 407148002912 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 407148002913 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 407148002914 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 407148002915 Walker A/P-loop; other site 407148002916 ATP binding site [chemical binding]; other site 407148002917 Q-loop/lid; other site 407148002918 ABC transporter signature motif; other site 407148002919 Walker B; other site 407148002920 D-loop; other site 407148002921 H-loop/switch region; other site 407148002922 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 407148002923 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 407148002924 Walker A/P-loop; other site 407148002925 ATP binding site [chemical binding]; other site 407148002926 Q-loop/lid; other site 407148002927 ABC transporter signature motif; other site 407148002928 Walker B; other site 407148002929 D-loop; other site 407148002930 H-loop/switch region; other site 407148002931 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 407148002932 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 407148002933 TM-ABC transporter signature motif; other site 407148002934 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 407148002935 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 407148002936 TM-ABC transporter signature motif; other site 407148002937 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 407148002938 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 407148002939 putative ligand binding site [chemical binding]; other site 407148002940 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 407148002941 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 407148002942 putative ligand binding site [chemical binding]; other site 407148002943 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 407148002944 Cytochrome c; Region: Cytochrom_C; cl11414 407148002945 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 407148002946 Predicted membrane protein [Function unknown]; Region: COG2862 407148002947 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 407148002948 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 407148002949 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 407148002950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 407148002951 active site 407148002952 phosphorylation site [posttranslational modification] 407148002953 intermolecular recognition site; other site 407148002954 dimerization interface [polypeptide binding]; other site 407148002955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148002956 Walker A motif; other site 407148002957 ATP binding site [chemical binding]; other site 407148002958 Walker B motif; other site 407148002959 arginine finger; other site 407148002960 LPP20 lipoprotein; Region: LPP20; cl15824 407148002961 DNA gyrase subunit A; Validated; Region: PRK05560 407148002962 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 407148002963 CAP-like domain; other site 407148002964 active site 407148002965 primary dimer interface [polypeptide binding]; other site 407148002966 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 407148002967 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 407148002968 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 407148002969 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 407148002970 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 407148002971 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 407148002972 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 407148002973 active site 407148002974 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 407148002975 GTP-binding protein LepA; Provisional; Region: PRK05433 407148002976 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 407148002977 G1 box; other site 407148002978 putative GEF interaction site [polypeptide binding]; other site 407148002979 GTP/Mg2+ binding site [chemical binding]; other site 407148002980 Switch I region; other site 407148002981 G2 box; other site 407148002982 G3 box; other site 407148002983 Switch II region; other site 407148002984 G4 box; other site 407148002985 G5 box; other site 407148002986 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 407148002987 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 407148002988 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 407148002989 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 407148002990 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 407148002991 HlyD family secretion protein; Region: HlyD_3; pfam13437 407148002992 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 407148002993 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 407148002994 HSP70 interaction site [polypeptide binding]; other site 407148002995 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 407148002996 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 407148002997 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 407148002998 acetyl-CoA carboxylase subunit A; Validated; Region: PRK08463 407148002999 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 407148003000 ATP-grasp domain; Region: ATP-grasp_4; cl17255 407148003001 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 407148003002 cell division protein FtsW; Region: ftsW; TIGR02614 407148003003 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 407148003004 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 407148003005 active site 407148003006 homodimer interface [polypeptide binding]; other site 407148003007 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 407148003008 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 407148003009 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 407148003010 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 407148003011 thiamine phosphate binding site [chemical binding]; other site 407148003012 active site 407148003013 pyrophosphate binding site [ion binding]; other site 407148003014 thiazole biosynthesis protein ThiH; Region: thiH; TIGR02351 407148003015 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 407148003016 FeS/SAM binding site; other site 407148003017 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 407148003018 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 407148003019 ThiS interaction site; other site 407148003020 putative active site [active] 407148003021 tetramer interface [polypeptide binding]; other site 407148003022 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 407148003023 thiamine biosynthesis protein ThiF, family 2; Region: thiF_fam2; TIGR02354 407148003024 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 407148003025 putative ATP binding site [chemical binding]; other site 407148003026 putative substrate interface [chemical binding]; other site 407148003027 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 407148003028 thiS-thiF/thiG interaction site; other site 407148003029 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 407148003030 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 407148003031 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 407148003032 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 407148003033 Methyltransferase domain; Region: Methyltransf_26; pfam13659 407148003034 succinyl-diaminopimelate desuccinylase, proteobacterial clade; Region: dapE_proteo; TIGR01246 407148003035 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 407148003036 metal binding site [ion binding]; metal-binding site 407148003037 dimer interface [polypeptide binding]; other site 407148003038 LysE type translocator; Region: LysE; pfam01810 407148003039 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 407148003040 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 407148003041 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 407148003042 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 407148003043 Methyltransferase domain; Region: Methyltransf_26; pfam13659 407148003044 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 407148003045 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 407148003046 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 407148003047 guanylate kinase; Region: PLN02772 407148003048 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 407148003049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 407148003050 Walker A/P-loop; other site 407148003051 ATP binding site [chemical binding]; other site 407148003052 Q-loop/lid; other site 407148003053 ABC transporter signature motif; other site 407148003054 Walker B; other site 407148003055 D-loop; other site 407148003056 H-loop/switch region; other site 407148003057 Smr domain; Region: Smr; pfam01713 407148003058 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 407148003059 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 407148003060 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 407148003061 Predicted amidohydrolase [General function prediction only]; Region: COG0388 407148003062 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 407148003063 active site 407148003064 catalytic triad [active] 407148003065 dimer interface [polypeptide binding]; other site 407148003066 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 407148003067 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 407148003068 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 407148003069 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 407148003070 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 407148003071 active site 407148003072 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 407148003073 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 407148003074 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 407148003075 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 407148003076 active site 407148003077 HIGH motif; other site 407148003078 nucleotide binding site [chemical binding]; other site 407148003079 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 407148003080 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 407148003081 active site 407148003082 KMSKS motif; other site 407148003083 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 407148003084 tRNA binding surface [nucleotide binding]; other site 407148003085 anticodon binding site; other site 407148003086 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 407148003087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 407148003088 Coenzyme A binding pocket [chemical binding]; other site 407148003089 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 407148003090 FMN binding site [chemical binding]; other site 407148003091 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 407148003092 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 407148003093 dimer interface [polypeptide binding]; other site 407148003094 FMN binding site [chemical binding]; other site 407148003095 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 407148003096 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 407148003097 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 407148003098 active site 407148003099 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 407148003100 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 407148003101 putative substrate binding region [chemical binding]; other site 407148003102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 407148003103 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 407148003104 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 407148003105 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 407148003106 dimer interface [polypeptide binding]; other site 407148003107 ssDNA binding site [nucleotide binding]; other site 407148003108 tetramer (dimer of dimers) interface [polypeptide binding]; other site 407148003109 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 407148003110 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 407148003111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148003112 Walker A motif; other site 407148003113 ATP binding site [chemical binding]; other site 407148003114 Walker B motif; other site 407148003115 arginine finger; other site 407148003116 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 407148003117 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 407148003118 flagellar assembly protein FliW; Provisional; Region: PRK13282 407148003119 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 407148003120 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 407148003121 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 407148003122 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 407148003123 active site 407148003124 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 407148003125 thiamine phosphate binding site [chemical binding]; other site 407148003126 active site 407148003127 pyrophosphate binding site [ion binding]; other site 407148003128 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 407148003129 substrate binding site [chemical binding]; other site 407148003130 dimer interface [polypeptide binding]; other site 407148003131 ATP binding site [chemical binding]; other site 407148003132 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 407148003133 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 407148003134 minor groove reading motif; other site 407148003135 helix-hairpin-helix signature motif; other site 407148003136 active site 407148003137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148003138 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 407148003139 Walker A motif; other site 407148003140 ATP binding site [chemical binding]; other site 407148003141 Walker B motif; other site 407148003142 arginine finger; other site 407148003143 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 407148003144 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 407148003145 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 407148003146 ATP binding site [chemical binding]; other site 407148003147 putative Mg++ binding site [ion binding]; other site 407148003148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 407148003149 nucleotide binding region [chemical binding]; other site 407148003150 ATP-binding site [chemical binding]; other site 407148003151 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 407148003152 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 407148003153 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 407148003154 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 407148003155 Peptidase family M23; Region: Peptidase_M23; pfam01551 407148003156 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 407148003157 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 407148003158 Lipopolysaccharide-assembly; Region: LptE; pfam04390 407148003159 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 407148003160 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 407148003161 HIGH motif; other site 407148003162 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 407148003163 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 407148003164 active site 407148003165 KMSKS motif; other site 407148003166 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 407148003167 tRNA binding surface [nucleotide binding]; other site 407148003168 anticodon binding site; other site 407148003169 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 407148003170 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 407148003171 Protein export membrane protein; Region: SecD_SecF; pfam02355 407148003172 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 407148003173 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 407148003174 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 407148003175 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 407148003176 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 407148003177 active site 407148003178 catalytic triad [active] 407148003179 S-adenosylmethionine synthetase; Validated; Region: PRK05250 407148003180 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 407148003181 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 407148003182 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 407148003183 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 407148003184 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 407148003185 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 407148003186 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 407148003187 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 407148003188 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 407148003189 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 407148003190 active site 407148003191 Zn binding site [ion binding]; other site 407148003192 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 407148003193 Part of AAA domain; Region: AAA_19; pfam13245 407148003194 Family description; Region: UvrD_C_2; pfam13538 407148003195 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04099 407148003196 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 407148003197 active site 407148003198 RNA-binding global regulator CsrA [Signal transduction mechanisms]; Region: CsrA; COG1551 407148003199 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 407148003200 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 407148003201 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 407148003202 SmpB-tmRNA interface; other site 407148003203 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 407148003204 catalytic residues [active] 407148003205 Uncharacterized conserved protein [Function unknown]; Region: COG2127 407148003206 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 407148003207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148003208 Walker A motif; other site 407148003209 ATP binding site [chemical binding]; other site 407148003210 Walker B motif; other site 407148003211 arginine finger; other site 407148003212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148003213 Walker A motif; other site 407148003214 ATP binding site [chemical binding]; other site 407148003215 Walker B motif; other site 407148003216 arginine finger; other site 407148003217 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 407148003218 Leu/Phe-tRNA-protein transferase [Posttranslational modification, protein turnover, chaperones]; Region: Aat; COG2360 407148003219 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 407148003220 PAS domain; Region: PAS_9; pfam13426 407148003221 putative active site [active] 407148003222 heme pocket [chemical binding]; other site 407148003223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 407148003224 PAS domain; Region: PAS_9; pfam13426 407148003225 putative active site [active] 407148003226 heme pocket [chemical binding]; other site 407148003227 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 407148003228 dimer interface [polypeptide binding]; other site 407148003229 putative CheW interface [polypeptide binding]; other site 407148003230 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 407148003231 methionine sulfoxide reductase B; Provisional; Region: PRK05508 407148003232 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 407148003233 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 407148003234 dinuclear metal binding motif [ion binding]; other site 407148003235 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 407148003236 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 407148003237 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 407148003238 Phosphatidylserine decarboxylase [Lipid metabolism]; Region: Psd; COG0688 407148003239 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 407148003240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148003241 Walker A motif; other site 407148003242 ATP binding site [chemical binding]; other site 407148003243 Walker B motif; other site 407148003244 arginine finger; other site 407148003245 Peptidase family M41; Region: Peptidase_M41; pfam01434 407148003246 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 407148003247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148003248 S-adenosylmethionine binding site [chemical binding]; other site 407148003249 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 407148003250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 407148003251 active site 407148003252 phosphorylation site [posttranslational modification] 407148003253 intermolecular recognition site; other site 407148003254 dimerization interface [polypeptide binding]; other site 407148003255 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 407148003256 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 407148003257 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 407148003258 NAD(P) binding site [chemical binding]; other site 407148003259 homodimer interface [polypeptide binding]; other site 407148003260 substrate binding site [chemical binding]; other site 407148003261 active site 407148003262 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 407148003263 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 407148003264 inhibitor-cofactor binding pocket; inhibition site 407148003265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148003266 catalytic residue [active] 407148003267 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 407148003268 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 407148003269 putative trimer interface [polypeptide binding]; other site 407148003270 putative CoA binding site [chemical binding]; other site 407148003271 Bacterial sugar transferase; Region: Bac_transf; pfam02397 407148003272 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 407148003273 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 407148003274 putative ADP-binding pocket [chemical binding]; other site 407148003275 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 407148003276 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 407148003277 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 407148003278 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 407148003279 putative ADP-binding pocket [chemical binding]; other site 407148003280 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 407148003281 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 407148003282 active site 407148003283 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 407148003284 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 407148003285 putative ADP-binding pocket [chemical binding]; other site 407148003286 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 407148003287 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 407148003288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 407148003289 Walker A/P-loop; other site 407148003290 ATP binding site [chemical binding]; other site 407148003291 Q-loop/lid; other site 407148003292 ABC transporter signature motif; other site 407148003293 Walker B; other site 407148003294 D-loop; other site 407148003295 H-loop/switch region; other site 407148003296 UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179 407148003297 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 407148003298 NAD binding site [chemical binding]; other site 407148003299 homodimer interface [polypeptide binding]; other site 407148003300 active site 407148003301 substrate binding site [chemical binding]; other site 407148003302 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 407148003303 active site 407148003304 catalytic site [active] 407148003305 substrate binding site [chemical binding]; other site 407148003306 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 407148003307 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 407148003308 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 407148003309 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 407148003310 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 407148003311 putative active site [active] 407148003312 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 407148003313 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 407148003314 putative acyl-acceptor binding pocket; other site 407148003315 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 407148003316 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 407148003317 putative metal binding site; other site 407148003318 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 407148003319 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 407148003320 substrate binding site; other site 407148003321 tetramer interface; other site 407148003322 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 407148003323 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 407148003324 NAD binding site [chemical binding]; other site 407148003325 substrate binding site [chemical binding]; other site 407148003326 homodimer interface [polypeptide binding]; other site 407148003327 active site 407148003328 WxcM-like, C-terminal; Region: FdtA; pfam05523 407148003329 WxcM-like, C-terminal; Region: FdtA; pfam05523 407148003330 putative trimer interface [polypeptide binding]; other site 407148003331 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 407148003332 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 407148003333 putative CoA binding site [chemical binding]; other site 407148003334 putative trimer interface [polypeptide binding]; other site 407148003335 putative active site [active] 407148003336 putative substrate binding site [chemical binding]; other site 407148003337 putative CoA binding site [chemical binding]; other site 407148003338 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 407148003339 active site 407148003340 substrate binding site [chemical binding]; other site 407148003341 cosubstrate binding site; other site 407148003342 catalytic site [active] 407148003343 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 407148003344 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 407148003345 active site 407148003346 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 407148003347 active site 407148003348 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 407148003349 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 407148003350 inhibitor-cofactor binding pocket; inhibition site 407148003351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148003352 catalytic residue [active] 407148003353 Protein of unknown function (DUF2972); Region: DUF2972; pfam11186 407148003354 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA); Region: CgtA; pfam06306 407148003355 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 407148003356 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 407148003357 Bacterial protein of unknown function (HtrL_YibB); Region: HtrL_YibB; cl08171 407148003358 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 407148003359 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 407148003360 active site 407148003361 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 407148003362 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 407148003363 putative active site [active] 407148003364 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 407148003365 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 407148003366 dimer interface [polypeptide binding]; other site 407148003367 active site 407148003368 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 407148003369 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 407148003370 putative ribose interaction site [chemical binding]; other site 407148003371 putative ADP binding site [chemical binding]; other site 407148003372 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 407148003373 active site 407148003374 nucleotide binding site [chemical binding]; other site 407148003375 HIGH motif; other site 407148003376 KMSKS motif; other site 407148003377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 407148003378 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 407148003379 NAD(P) binding site [chemical binding]; other site 407148003380 active site 407148003381 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 407148003382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 407148003383 active site 407148003384 motif I; other site 407148003385 motif II; other site 407148003386 Cytochrome c553 [Energy production and conversion]; Region: COG2863 407148003387 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 407148003388 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 407148003389 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 407148003390 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 407148003391 metal-binding site [ion binding] 407148003392 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 407148003393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 407148003394 motif II; other site 407148003395 transcription termination factor Rho; Provisional; Region: rho; PRK09376 407148003396 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 407148003397 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 407148003398 RNA binding site [nucleotide binding]; other site 407148003399 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 407148003400 multimer interface [polypeptide binding]; other site 407148003401 Walker A motif; other site 407148003402 ATP binding site [chemical binding]; other site 407148003403 Walker B motif; other site 407148003404 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08451 407148003405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148003406 Walker A motif; other site 407148003407 ATP binding site [chemical binding]; other site 407148003408 DNA polymerase III subunit delta'; Validated; Region: PRK08485 407148003409 Walker B motif; other site 407148003410 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 407148003411 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 407148003412 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 407148003413 metal-binding site [ion binding] 407148003414 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 407148003415 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 407148003416 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 407148003417 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 407148003418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 407148003419 Uncharacterized conserved protein [Function unknown]; Region: COG3610 407148003420 Uncharacterized conserved protein [Function unknown]; Region: COG2966 407148003421 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 407148003422 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 407148003423 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 407148003424 NAD binding site [chemical binding]; other site 407148003425 dimer interface [polypeptide binding]; other site 407148003426 tetramer (dimer of dimers) interface [polypeptide binding]; other site 407148003427 substrate binding site [chemical binding]; other site 407148003428 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 407148003429 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 407148003430 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 407148003431 TraC-like protein; Region: TraC; cl06725 407148003432 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 407148003433 active site 407148003434 hypothetical protein; Provisional; Region: PRK12378 407148003435 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 407148003436 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 407148003437 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 407148003438 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 407148003439 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 407148003440 active site 407148003441 HIGH motif; other site 407148003442 KMSK motif region; other site 407148003443 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 407148003444 tRNA binding surface [nucleotide binding]; other site 407148003445 anticodon binding site; other site 407148003446 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 407148003447 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 407148003448 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 407148003449 catalytic site [active] 407148003450 G-X2-G-X-G-K; other site 407148003451 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 407148003452 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 407148003453 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 407148003454 Walker A/P-loop; other site 407148003455 ATP binding site [chemical binding]; other site 407148003456 Q-loop/lid; other site 407148003457 ABC transporter signature motif; other site 407148003458 Walker B; other site 407148003459 D-loop; other site 407148003460 H-loop/switch region; other site 407148003461 elongation factor Ts; Provisional; Region: tsf; PRK09377 407148003462 UBA/TS-N domain; Region: UBA; pfam00627 407148003463 Elongation factor TS; Region: EF_TS; pfam00889 407148003464 Elongation factor TS; Region: EF_TS; pfam00889 407148003465 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 407148003466 rRNA interaction site [nucleotide binding]; other site 407148003467 S8 interaction site; other site 407148003468 putative laminin-1 binding site; other site 407148003469 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 407148003470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148003471 S-adenosylmethionine binding site [chemical binding]; other site 407148003472 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 407148003473 Cytochrome c; Region: Cytochrom_C; pfam00034 407148003474 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 407148003475 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 407148003476 intrachain domain interface; other site 407148003477 interchain domain interface [polypeptide binding]; other site 407148003478 heme bH binding site [chemical binding]; other site 407148003479 Qi binding site; other site 407148003480 heme bL binding site [chemical binding]; other site 407148003481 Qo binding site; other site 407148003482 interchain domain interface [polypeptide binding]; other site 407148003483 intrachain domain interface; other site 407148003484 Qi binding site; other site 407148003485 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 407148003486 Qo binding site; other site 407148003487 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 407148003488 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 407148003489 [2Fe-2S] cluster binding site [ion binding]; other site 407148003490 arsenical pump membrane protein; Provisional; Region: PRK15445 407148003491 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 407148003492 transmembrane helices; other site 407148003493 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 407148003494 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 407148003495 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 407148003496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 407148003497 PAS domain; Region: PAS_9; pfam13426 407148003498 putative active site [active] 407148003499 heme pocket [chemical binding]; other site 407148003500 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 407148003501 dimer interface [polypeptide binding]; other site 407148003502 putative CheW interface [polypeptide binding]; other site 407148003503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 407148003504 PAS domain; Region: PAS_9; pfam13426 407148003505 putative active site [active] 407148003506 heme pocket [chemical binding]; other site 407148003507 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 407148003508 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 407148003509 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 407148003510 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 407148003511 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 407148003512 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 407148003513 dihydroorotase; Provisional; Region: PRK08417 407148003514 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 407148003515 active site 407148003516 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 407148003517 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 407148003518 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 407148003519 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 407148003520 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 407148003521 GatB domain; Region: GatB_Yqey; smart00845 407148003522 S-ribosylhomocysteinase; Provisional; Region: PRK02260 407148003523 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 407148003524 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 407148003525 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 407148003526 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 407148003527 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 407148003528 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 407148003529 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 407148003530 THF binding site; other site 407148003531 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 407148003532 substrate binding site [chemical binding]; other site 407148003533 THF binding site; other site 407148003534 zinc-binding site [ion binding]; other site 407148003535 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 407148003536 FAD binding site [chemical binding]; other site 407148003537 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 407148003538 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 407148003539 DNA repair protein RadA; Provisional; Region: PRK11823 407148003540 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 407148003541 Walker A motif; other site 407148003542 ATP binding site [chemical binding]; other site 407148003543 Walker B motif; other site 407148003544 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 407148003545 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 407148003546 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 407148003547 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 407148003548 P loop; other site 407148003549 GTP binding site [chemical binding]; other site 407148003550 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 407148003551 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 407148003552 catalytic residues [active] 407148003553 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 407148003554 phosphodiesterase; Provisional; Region: PRK12704 407148003555 KH domain; Region: KH_1; pfam00013 407148003556 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 407148003557 Zn2+ binding site [ion binding]; other site 407148003558 Mg2+ binding site [ion binding]; other site 407148003559 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 407148003560 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 407148003561 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 407148003562 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 407148003563 FAD binding domain; Region: FAD_binding_4; pfam01565 407148003564 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 407148003565 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 407148003566 Peptidase family M23; Region: Peptidase_M23; pfam01551 407148003567 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 407148003568 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 407148003569 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 407148003570 Lumazine binding domain; Region: Lum_binding; pfam00677 407148003571 Lumazine binding domain; Region: Lum_binding; pfam00677 407148003572 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 407148003573 oligomerisation interface [polypeptide binding]; other site 407148003574 mobile loop; other site 407148003575 roof hairpin; other site 407148003576 chaperonin GroL; Region: GroEL; TIGR02348 407148003577 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 407148003578 ring oligomerisation interface [polypeptide binding]; other site 407148003579 ATP/Mg binding site [chemical binding]; other site 407148003580 stacking interactions; other site 407148003581 hinge regions; other site 407148003582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 407148003583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 407148003584 dimer interface [polypeptide binding]; other site 407148003585 phosphorylation site [posttranslational modification] 407148003586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 407148003587 ATP binding site [chemical binding]; other site 407148003588 Mg2+ binding site [ion binding]; other site 407148003589 G-X-G motif; other site 407148003590 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 407148003591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 407148003592 active site 407148003593 phosphorylation site [posttranslational modification] 407148003594 intermolecular recognition site; other site 407148003595 dimerization interface [polypeptide binding]; other site 407148003596 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 407148003597 DNA binding site [nucleotide binding] 407148003598 Hemerythrin; Region: Hemerythrin; cd12107 407148003599 Fe binding site [ion binding]; other site 407148003600 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 407148003601 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 407148003602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 407148003603 dimer interface [polypeptide binding]; other site 407148003604 phosphorylation site [posttranslational modification] 407148003605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 407148003606 ATP binding site [chemical binding]; other site 407148003607 Mg2+ binding site [ion binding]; other site 407148003608 G-X-G motif; other site 407148003609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 407148003610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 407148003611 active site 407148003612 phosphorylation site [posttranslational modification] 407148003613 intermolecular recognition site; other site 407148003614 dimerization interface [polypeptide binding]; other site 407148003615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 407148003616 DNA binding site [nucleotide binding] 407148003617 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 407148003618 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 407148003619 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 407148003620 protein binding site [polypeptide binding]; other site 407148003621 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 407148003622 protein binding site [polypeptide binding]; other site 407148003623 chaperone protein DnaJ; Provisional; Region: PRK14299 407148003624 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 407148003625 HSP70 interaction site [polypeptide binding]; other site 407148003626 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 407148003627 substrate binding site [polypeptide binding]; other site 407148003628 dimer interface [polypeptide binding]; other site 407148003629 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 407148003630 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 407148003631 DNA binding residues [nucleotide binding] 407148003632 putative dimer interface [polypeptide binding]; other site 407148003633 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 407148003634 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 407148003635 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 407148003636 TrkA-N domain; Region: TrkA_N; pfam02254 407148003637 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 407148003638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 407148003639 motif II; other site 407148003640 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 407148003641 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 407148003642 Peptidase family M23; Region: Peptidase_M23; pfam01551 407148003643 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 407148003644 exopolyphosphatase; Region: exo_poly_only; TIGR03706 407148003645 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 407148003646 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 407148003647 active site 407148003648 hydrophilic channel; other site 407148003649 dimerization interface [polypeptide binding]; other site 407148003650 catalytic residues [active] 407148003651 active site lid [active] 407148003652 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946 407148003653 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 407148003654 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 407148003655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148003656 putative substrate translocation pore; other site 407148003657 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 407148003658 substrate binding site [chemical binding]; other site 407148003659 active site 407148003660 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 407148003661 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 407148003662 FeS/SAM binding site; other site 407148003663 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 407148003664 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 407148003665 GIY-YIG motif/motif A; other site 407148003666 active site 407148003667 catalytic site [active] 407148003668 putative DNA binding site [nucleotide binding]; other site 407148003669 metal binding site [ion binding]; metal-binding site 407148003670 UvrB/uvrC motif; Region: UVR; pfam02151 407148003671 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 407148003672 GMP synthase; Reviewed; Region: guaA; PRK00074 407148003673 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 407148003674 AMP/PPi binding site [chemical binding]; other site 407148003675 candidate oxyanion hole; other site 407148003676 catalytic triad [active] 407148003677 potential glutamine specificity residues [chemical binding]; other site 407148003678 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 407148003679 ATP Binding subdomain [chemical binding]; other site 407148003680 Ligand Binding sites [chemical binding]; other site 407148003681 Dimerization subdomain; other site 407148003682 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 407148003683 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 407148003684 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 407148003685 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 407148003686 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 407148003687 Predicted membrane protein/domain [Function unknown]; Region: COG1714 407148003688 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 407148003689 OstA-like protein; Region: OstA; cl00844 407148003690 Organic solvent tolerance protein; Region: OstA_C; pfam04453 407148003691 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 407148003692 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 407148003693 oligomer interface [polypeptide binding]; other site 407148003694 RNA binding site [nucleotide binding]; other site 407148003695 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 407148003696 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 407148003697 RNase E interface [polypeptide binding]; other site 407148003698 trimer interface [polypeptide binding]; other site 407148003699 active site 407148003700 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 407148003701 putative nucleic acid binding region [nucleotide binding]; other site 407148003702 G-X-X-G motif; other site 407148003703 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 407148003704 RNA binding site [nucleotide binding]; other site 407148003705 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 407148003706 putative active site [active] 407148003707 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 407148003708 dimer interface [polypeptide binding]; other site 407148003709 active site 1 [active] 407148003710 active site 2 [active] 407148003711 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 407148003712 drug efflux system protein MdtG; Provisional; Region: PRK09874 407148003713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148003714 putative substrate translocation pore; other site 407148003715 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 407148003716 Low molecular weight phosphatase family; Region: LMWPc; cd00115 407148003717 active site 407148003718 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 407148003719 chaperone protein DnaJ; Provisional; Region: PRK10767 407148003720 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 407148003721 HSP70 interaction site [polypeptide binding]; other site 407148003722 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 407148003723 substrate binding site [polypeptide binding]; other site 407148003724 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 407148003725 Zn binding sites [ion binding]; other site 407148003726 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 407148003727 dimer interface [polypeptide binding]; other site 407148003728 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 407148003729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 407148003730 active site 407148003731 phosphorylation site [posttranslational modification] 407148003732 intermolecular recognition site; other site 407148003733 dimerization interface [polypeptide binding]; other site 407148003734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 407148003735 DNA binding site [nucleotide binding] 407148003736 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 407148003737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 407148003738 dimer interface [polypeptide binding]; other site 407148003739 phosphorylation site [posttranslational modification] 407148003740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 407148003741 ATP binding site [chemical binding]; other site 407148003742 Mg2+ binding site [ion binding]; other site 407148003743 G-X-G motif; other site 407148003744 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 407148003745 RecR protein; Region: RecR; pfam02132 407148003746 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 407148003747 putative active site [active] 407148003748 putative metal-binding site [ion binding]; other site 407148003749 tetramer interface [polypeptide binding]; other site 407148003750 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 407148003751 putative substrate-binding site; other site 407148003752 nickel binding site [ion binding]; other site 407148003753 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 407148003754 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 407148003755 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 407148003756 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 407148003757 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 407148003758 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 407148003759 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 407148003760 Uncharacterized conserved protein [Function unknown]; Region: COG4121 407148003761 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 407148003762 AMIN domain; Region: AMIN; pfam11741 407148003763 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 407148003764 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 407148003765 active site 407148003766 metal binding site [ion binding]; metal-binding site 407148003767 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 407148003768 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 407148003769 FMN binding site [chemical binding]; other site 407148003770 substrate binding site [chemical binding]; other site 407148003771 putative catalytic residue [active] 407148003772 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 407148003773 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 407148003774 active site 407148003775 HIGH motif; other site 407148003776 dimer interface [polypeptide binding]; other site 407148003777 KMSKS motif; other site 407148003778 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 407148003779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 407148003780 Zn2+ binding site [ion binding]; other site 407148003781 Mg2+ binding site [ion binding]; other site 407148003782 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 407148003783 synthetase active site [active] 407148003784 NTP binding site [chemical binding]; other site 407148003785 metal binding site [ion binding]; metal-binding site 407148003786 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 407148003787 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 407148003788 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 407148003789 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 407148003790 putative nucleotide binding site [chemical binding]; other site 407148003791 uridine monophosphate binding site [chemical binding]; other site 407148003792 homohexameric interface [polypeptide binding]; other site 407148003793 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 407148003794 Peptidase family M23; Region: Peptidase_M23; pfam01551 407148003795 FtsX-like permease family; Region: FtsX; pfam02687 407148003796 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 407148003797 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 407148003798 Walker A/P-loop; other site 407148003799 ATP binding site [chemical binding]; other site 407148003800 Q-loop/lid; other site 407148003801 ABC transporter signature motif; other site 407148003802 Walker B; other site 407148003803 D-loop; other site 407148003804 H-loop/switch region; other site 407148003805 tRNA (guanine-N(7)-)-methyltransferase; Provisional; Region: PRK14121 407148003806 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 407148003807 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 407148003808 Interdomain contacts; other site 407148003809 Cytokine receptor motif; other site 407148003810 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 407148003811 Interdomain contacts; other site 407148003812 Cytokine receptor motif; other site 407148003813 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 407148003814 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 407148003815 RNA binding surface [nucleotide binding]; other site 407148003816 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 407148003817 active site 407148003818 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 407148003819 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 407148003820 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 407148003821 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 407148003822 TrkA-N domain; Region: TrkA_N; pfam02254 407148003823 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 407148003824 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 407148003825 active site 407148003826 Malic enzyme, N-terminal domain; Region: malic; pfam00390 407148003827 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 407148003828 putative NAD(P) binding site [chemical binding]; other site 407148003829 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 407148003830 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 407148003831 active site 407148003832 HIGH motif; other site 407148003833 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 407148003834 active site 407148003835 KMSKS motif; other site 407148003836 SurA N-terminal domain; Region: SurA_N; pfam09312 407148003837 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 407148003838 biotin carboxylase; Validated; Region: PRK08462 407148003839 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 407148003840 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 407148003841 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 407148003842 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 407148003843 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 407148003844 carboxyltransferase (CT) interaction site; other site 407148003845 biotinylation site [posttranslational modification]; other site 407148003846 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 407148003847 trimer interface [polypeptide binding]; other site 407148003848 active site 407148003849 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 407148003850 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 407148003851 NAD(P) binding site [chemical binding]; other site 407148003852 homodimer interface [polypeptide binding]; other site 407148003853 substrate binding site [chemical binding]; other site 407148003854 active site 407148003855 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 407148003856 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 407148003857 inhibitor-cofactor binding pocket; inhibition site 407148003858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 407148003859 catalytic residue [active] 407148003860 Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain [General function prediction only]; Region: COG4310 407148003861 M28 Zn-Peptidases; Region: M28_like_3; cd05644 407148003862 active site 407148003863 metal binding site [ion binding]; metal-binding site 407148003864 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 407148003865 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 407148003866 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 407148003867 acyl-activating enzyme (AAE) consensus motif; other site 407148003868 AMP binding site [chemical binding]; other site 407148003869 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 407148003870 active site 407148003871 cosubstrate binding site; other site 407148003872 substrate binding site [chemical binding]; other site 407148003873 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 407148003874 catalytic site [active] 407148003875 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 407148003876 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 407148003877 ligand binding site; other site 407148003878 tetramer interface; other site 407148003879 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 407148003880 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 407148003881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 407148003882 Coenzyme A binding pocket [chemical binding]; other site 407148003883 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 407148003884 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 407148003885 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 407148003886 substrate binding site [chemical binding]; other site 407148003887 glutamase interaction surface [polypeptide binding]; other site 407148003888 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 407148003889 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 407148003890 putative active site [active] 407148003891 oxyanion strand; other site 407148003892 catalytic triad [active] 407148003893 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 407148003894 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 407148003895 Ligand Binding Site [chemical binding]; other site 407148003896 pseudaminic acid synthase; Region: PseI; TIGR03586 407148003897 NeuB family; Region: NeuB; pfam03102 407148003898 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 407148003899 NeuB binding interface [polypeptide binding]; other site 407148003900 putative substrate binding site [chemical binding]; other site 407148003901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 407148003902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 407148003903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 407148003904 flagellin; Provisional; Region: PRK13589 407148003905 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 407148003906 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 407148003907 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 407148003908 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 407148003909 flagellin; Reviewed; Region: PRK08411 407148003910 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 407148003911 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 407148003912 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 407148003913 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 407148003914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 407148003915 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 407148003916 UGMP family protein; Validated; Region: PRK09604 407148003917 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 407148003918 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 407148003919 active site 407148003920 Zn binding site [ion binding]; other site 407148003921 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 407148003922 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 407148003923 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 407148003924 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 407148003925 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 407148003926 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 407148003927 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 407148003928 Domain of unknown function (DUF814); Region: DUF814; pfam05670 407148003929 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 407148003930 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 407148003931 GTP binding site; other site 407148003932 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 407148003933 dimerization interface [polypeptide binding]; other site 407148003934 substrate binding site [chemical binding]; other site 407148003935 active site 407148003936 calcium binding site [ion binding]; other site 407148003937 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 407148003938 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 407148003939 ABC-ATPase subunit interface; other site 407148003940 dimer interface [polypeptide binding]; other site 407148003941 putative PBP binding regions; other site 407148003942 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 407148003943 ABC-ATPase subunit interface; other site 407148003944 dimer interface [polypeptide binding]; other site 407148003945 putative PBP binding regions; other site 407148003946 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 407148003947 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 407148003948 Walker A/P-loop; other site 407148003949 ATP binding site [chemical binding]; other site 407148003950 Q-loop/lid; other site 407148003951 ABC transporter signature motif; other site 407148003952 Walker B; other site 407148003953 D-loop; other site 407148003954 H-loop/switch region; other site 407148003955 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 407148003956 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 407148003957 putative ligand binding residues [chemical binding]; other site 407148003958 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 407148003959 Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit [Inorganic ion transport and metabolism]; Region: NrfA; COG3303 407148003960 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 407148003961 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 407148003962 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 407148003963 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 407148003964 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 407148003965 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 407148003966 putative domain interface [polypeptide binding]; other site 407148003967 putative active site [active] 407148003968 catalytic site [active] 407148003969 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 407148003970 putative domain interface [polypeptide binding]; other site 407148003971 putative active site [active] 407148003972 catalytic site [active] 407148003973 Autotransporter beta-domain; Region: Autotransporter; smart00869 407148003974 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 407148003975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148003976 Walker A motif; other site 407148003977 ATP binding site [chemical binding]; other site 407148003978 Walker B motif; other site 407148003979 arginine finger; other site 407148003980 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 407148003981 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 407148003982 Domain of unknown function DUF20; Region: UPF0118; pfam01594 407148003983 fumarate hydratase; Reviewed; Region: fumC; PRK00485 407148003984 Class II fumarases; Region: Fumarase_classII; cd01362 407148003985 active site 407148003986 tetramer interface [polypeptide binding]; other site 407148003987 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 407148003988 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 407148003989 glutaminase active site [active] 407148003990 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 407148003991 dimer interface [polypeptide binding]; other site 407148003992 active site 407148003993 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 407148003994 dimer interface [polypeptide binding]; other site 407148003995 active site 407148003996 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 407148003997 hypothetical protein; Provisional; Region: PRK08444 407148003998 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 407148003999 FeS/SAM binding site; other site 407148004000 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 407148004001 Sulfate transporter family; Region: Sulfate_transp; pfam00916 407148004002 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 407148004003 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 407148004004 active site 407148004005 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 407148004006 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854 407148004007 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 407148004008 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 407148004009 active site 407148004010 dimerization interface [polypeptide binding]; other site 407148004011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148004012 Major Facilitator Superfamily; Region: MFS_1; pfam07690 407148004013 putative substrate translocation pore; other site 407148004014 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 407148004015 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 407148004016 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 407148004017 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 407148004018 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 407148004019 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 407148004020 G1 box; other site 407148004021 putative GEF interaction site [polypeptide binding]; other site 407148004022 GTP/Mg2+ binding site [chemical binding]; other site 407148004023 Switch I region; other site 407148004024 G2 box; other site 407148004025 G3 box; other site 407148004026 Switch II region; other site 407148004027 G4 box; other site 407148004028 G5 box; other site 407148004029 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 407148004030 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 407148004031 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 407148004032 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 407148004033 flavodoxin FldA; Validated; Region: PRK09267 407148004034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4378 407148004035 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 407148004036 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 407148004037 tetramer interface [polypeptide binding]; other site 407148004038 heme binding pocket [chemical binding]; other site 407148004039 NADPH binding site [chemical binding]; other site 407148004040 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 407148004041 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 407148004042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 407148004043 YheO-like PAS domain; Region: PAS_6; pfam08348 407148004044 HTH domain; Region: HTH_22; pfam13309 407148004045 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 407148004046 homotrimer interaction site [polypeptide binding]; other site 407148004047 putative active site [active] 407148004048 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 407148004049 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 407148004050 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 407148004051 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 407148004052 catalytic residue [active] 407148004053 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 407148004054 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 407148004055 tetramer interface [polypeptide binding]; other site 407148004056 active site 407148004057 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 407148004058 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 407148004059 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 407148004060 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 407148004061 G1 box; other site 407148004062 GTP/Mg2+ binding site [chemical binding]; other site 407148004063 Switch I region; other site 407148004064 G2 box; other site 407148004065 G3 box; other site 407148004066 Switch II region; other site 407148004067 G4 box; other site 407148004068 G5 box; other site 407148004069 Nucleoside recognition; Region: Gate; pfam07670 407148004070 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 407148004071 Nucleoside recognition; Region: Gate; pfam07670 407148004072 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 407148004073 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 407148004074 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415 407148004075 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 407148004076 NAD binding site [chemical binding]; other site 407148004077 homotetramer interface [polypeptide binding]; other site 407148004078 homodimer interface [polypeptide binding]; other site 407148004079 substrate binding site [chemical binding]; other site 407148004080 active site 407148004081 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 407148004082 triosephosphate isomerase; Provisional; Region: PRK14565 407148004083 substrate binding site [chemical binding]; other site 407148004084 dimer interface [polypeptide binding]; other site 407148004085 catalytic triad [active] 407148004086 Phosphoglycerate kinase; Region: PGK; pfam00162 407148004087 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 407148004088 substrate binding site [chemical binding]; other site 407148004089 hinge regions; other site 407148004090 ADP binding site [chemical binding]; other site 407148004091 catalytic site [active] 407148004092 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 407148004093 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 407148004094 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 407148004095 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 407148004096 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 407148004097 active site 407148004098 (T/H)XGH motif; other site 407148004099 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 407148004100 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 407148004101 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 407148004102 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 407148004103 active site 407148004104 substrate binding site [chemical binding]; other site 407148004105 metal binding site [ion binding]; metal-binding site 407148004106 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK08455 407148004107 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 407148004108 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 407148004109 Cytochrome P450; Region: p450; cl12078 407148004110 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 407148004111 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 407148004112 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 407148004113 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182 407148004114 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 407148004115 putative active site [active] 407148004116 metal binding site [ion binding]; metal-binding site 407148004117 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 407148004118 PYR/PP interface [polypeptide binding]; other site 407148004119 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 407148004120 dimer interface [polypeptide binding]; other site 407148004121 TPP binding site [chemical binding]; other site 407148004122 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 407148004123 TPP-binding site [chemical binding]; other site 407148004124 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 407148004125 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 407148004126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 407148004127 active site 407148004128 nucleotide binding site [chemical binding]; other site 407148004129 HIGH motif; other site 407148004130 KMSKS motif; other site 407148004131 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 407148004132 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 407148004133 ligand binding site; other site 407148004134 tetramer interface; other site 407148004135 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 407148004136 ligand-binding site [chemical binding]; other site 407148004137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 407148004138 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 407148004139 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u2_5s; cd10971 407148004140 putative active site [active] 407148004141 putative metal binding site [ion binding]; other site 407148004142 Protein of unknown function (DUF2972); Region: DUF2972; pfam11186 407148004143 Oligosaccharyltransferase 48 kDa subunit beta; Region: DDOST_48kD; pfam03345 407148004144 Methyltransferase domain; Region: Methyltransf_23; pfam13489 407148004145 Methyltransferase domain; Region: Methyltransf_11; pfam08241 407148004146 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 407148004147 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 407148004148 active site 407148004149 homodimer interface [polypeptide binding]; other site 407148004150 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 407148004151 NeuB family; Region: NeuB; pfam03102 407148004152 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 407148004153 NeuB binding interface [polypeptide binding]; other site 407148004154 putative substrate binding site [chemical binding]; other site 407148004155 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 407148004156 active site 407148004157 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 407148004158 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 407148004159 Ligand binding site; other site 407148004160 metal-binding site 407148004161 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 407148004162 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 407148004163 Ligand binding site; other site 407148004164 metal-binding site 407148004165 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 407148004166 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 407148004167 UDP-galactopyranose mutase; Region: GLF; pfam03275 407148004168 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 407148004169 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 407148004170 NAD binding site [chemical binding]; other site 407148004171 homodimer interface [polypeptide binding]; other site 407148004172 active site 407148004173 substrate binding site [chemical binding]; other site 407148004174 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 407148004175 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 407148004176 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 407148004177 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 407148004178 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 407148004179 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 407148004180 NAD binding site [chemical binding]; other site 407148004181 putative substrate binding site 2 [chemical binding]; other site 407148004182 putative substrate binding site 1 [chemical binding]; other site 407148004183 active site 407148004184 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 407148004185 active site 407148004186 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 407148004187 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 407148004188 active site 407148004189 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 407148004190 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 407148004191 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 407148004192 KpsF/GutQ family protein; Region: kpsF; TIGR00393 407148004193 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 407148004194 putative active site [active] 407148004195 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 407148004196 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 407148004197 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 407148004198 SLBB domain; Region: SLBB; pfam10531 407148004199 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 407148004200 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 407148004201 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 407148004202 Walker A/P-loop; other site 407148004203 ATP binding site [chemical binding]; other site 407148004204 Q-loop/lid; other site 407148004205 ABC transporter signature motif; other site 407148004206 Walker B; other site 407148004207 D-loop; other site 407148004208 H-loop/switch region; other site 407148004209 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 407148004210 ABC-2 type transporter; Region: ABC2_membrane; cl17235 407148004211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787 407148004212 dUTPase; Region: dUTPase_2; pfam08761 407148004213 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 407148004214 active site 407148004215 homodimer interface [polypeptide binding]; other site 407148004216 metal binding site [ion binding]; metal-binding site 407148004217 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 407148004218 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 407148004219 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 407148004220 Ligand Binding Site [chemical binding]; other site 407148004221 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 407148004222 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 407148004223 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 407148004224 FeS/SAM binding site; other site 407148004225 peptide chain release factor 2; Validated; Region: prfB; PRK00578 407148004226 This domain is found in peptide chain release factors; Region: PCRF; smart00937 407148004227 RF-1 domain; Region: RF-1; pfam00472 407148004228 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 407148004229 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 407148004230 Permutation of conserved domain; other site 407148004231 active site 407148004232 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 407148004233 thiamine monophosphate kinase; Provisional; Region: PRK05731 407148004234 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 407148004235 ATP binding site [chemical binding]; other site 407148004236 dimerization interface [polypeptide binding]; other site 407148004237 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 407148004238 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 407148004239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 407148004240 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 407148004241 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 407148004242 Rod binding protein; Region: Rod-binding; cl01626 407148004243 FlgN protein; Region: FlgN; pfam05130 407148004244 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 407148004245 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 407148004246 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 407148004247 hypothetical protein; Provisional; Region: PRK10621 407148004248 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 407148004249 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 407148004250 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 407148004251 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 407148004252 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 407148004253 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 407148004254 Walker A motif; other site 407148004255 ATP binding site [chemical binding]; other site 407148004256 Walker B motif; other site 407148004257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 407148004258 AAA domain; Region: AAA_22; pfam13401 407148004259 Walker A motif; other site 407148004260 ATP binding site [chemical binding]; other site 407148004261 Walker B motif; other site 407148004262 arginine finger; other site 407148004263 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 407148004264 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 407148004265 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 407148004266 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 407148004267 dimer interface [polypeptide binding]; other site 407148004268 PYR/PP interface [polypeptide binding]; other site 407148004269 TPP binding site [chemical binding]; other site 407148004270 substrate binding site [chemical binding]; other site 407148004271 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 407148004272 Domain of unknown function; Region: EKR; pfam10371 407148004273 4Fe-4S binding domain; Region: Fer4_6; pfam12837 407148004274 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 407148004275 TPP-binding site [chemical binding]; other site 407148004276 dimer interface [polypeptide binding]; other site 407148004277 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 407148004278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 407148004279 motif II; other site 407148004280 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 407148004281 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 407148004282 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 407148004283 ligand binding site [chemical binding]; other site 407148004284 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 407148004285 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 407148004286 23S rRNA interface [nucleotide binding]; other site 407148004287 L3 interface [polypeptide binding]; other site 407148004288 Part of AAA domain; Region: AAA_19; pfam13245 407148004289 putative recombination protein RecB; Provisional; Region: PRK13909 407148004290 Family description; Region: UvrD_C_2; pfam13538 407148004291 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 407148004292 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 407148004293 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 407148004294 FixH; Region: FixH; pfam05751 407148004295 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 407148004296 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 407148004297 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 407148004298 Cytochrome c; Region: Cytochrom_C; cl11414 407148004299 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 407148004300 cytochrome c oxidase, cbb3-type, CcoQ subunit, epsilon-Proteobacterial; Region: cbb3_Q_epsi; TIGR02736 407148004301 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 407148004302 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 407148004303 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 407148004304 Low-spin heme binding site [chemical binding]; other site 407148004305 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 407148004306 D-pathway; other site 407148004307 Putative water exit pathway; other site 407148004308 Binuclear center (active site) [active] 407148004309 K-pathway; other site 407148004310 Putative proton exit pathway; other site 407148004311 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 407148004312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 407148004313 active site 407148004314 phosphorylation site [posttranslational modification] 407148004315 intermolecular recognition site; other site 407148004316 dimerization interface [polypeptide binding]; other site 407148004317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 407148004318 DNA binding site [nucleotide binding] 407148004319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 407148004320 PAS domain; Region: PAS_9; pfam13426 407148004321 putative active site [active] 407148004322 heme pocket [chemical binding]; other site 407148004323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 407148004324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 407148004325 ATP binding site [chemical binding]; other site 407148004326 Mg2+ binding site [ion binding]; other site 407148004327 G-X-G motif; other site 407148004328 Uncharacterized conserved protein [Function unknown]; Region: COG2836 407148004329 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 407148004330 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 407148004331 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 407148004332 catalytic site [active] 407148004333 subunit interface [polypeptide binding]; other site 407148004334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2952 407148004335 Uncharacterized conserved protein [Function unknown]; Region: COG3334 407148004336 Flagellar FliJ protein; Region: FliJ; pfam02050 407148004337 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 407148004338 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 407148004339 GDP-binding site [chemical binding]; other site 407148004340 ACT binding site; other site 407148004341 IMP binding site; other site 407148004342 putative inner membrane protein; Provisional; Region: PRK11099 407148004343 Sulphur transport; Region: Sulf_transp; pfam04143 407148004344 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 407148004345 Sulphur transport; Region: Sulf_transp; pfam04143 407148004346 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 407148004347 CPxP motif; other site 407148004348 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 407148004349 Na binding site [ion binding]; other site 407148004350 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 407148004351 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 407148004352 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 407148004353 Glutamate binding site [chemical binding]; other site 407148004354 NAD binding site [chemical binding]; other site 407148004355 catalytic residues [active] 407148004356 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 407148004357 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 407148004358 dimerization interface [polypeptide binding]; other site 407148004359 putative ATP binding site [chemical binding]; other site 407148004360 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 407148004361 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 407148004362 CPxP motif; other site 407148004363 Cache domain; Region: Cache_1; pfam02743 407148004364 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 407148004365 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 407148004366 dimer interface [polypeptide binding]; other site 407148004367 putative CheW interface [polypeptide binding]; other site 407148004368 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 407148004369 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 407148004370 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 407148004371 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 407148004372 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 407148004373 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 407148004374 molybdopterin cofactor binding site; other site 407148004375 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 407148004376 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 407148004377 molybdopterin cofactor binding site; other site 407148004378 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 407148004379 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 407148004380 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 407148004381 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 407148004382 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 407148004383 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 407148004384 dimer interface [polypeptide binding]; other site 407148004385 active site 407148004386 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 407148004387 catalytic residues [active] 407148004388 substrate binding site [chemical binding]; other site 407148004389 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 407148004390 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 407148004391 Multicopper oxidase; Region: Cu-oxidase; pfam00394 407148004392 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 407148004393 ThiS family; Region: ThiS; pfam02597 407148004394 charged pocket; other site 407148004395 hydrophobic patch; other site 407148004396 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 407148004397 MoaE homodimer interface [polypeptide binding]; other site 407148004398 MoaD interaction [polypeptide binding]; other site 407148004399 active site residues [active] 407148004400 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 407148004401 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 407148004402 dimer interface [polypeptide binding]; other site 407148004403 putative functional site; other site 407148004404 putative MPT binding site; other site 407148004405 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 407148004406 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 407148004407 Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513 407148004408 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 407148004409 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 407148004410 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 407148004411 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 407148004412 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 407148004413 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 407148004414 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 407148004415 dimerization interface [polypeptide binding]; other site 407148004416 putative ATP binding site [chemical binding]; other site 407148004417 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 407148004418 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 407148004419 CoA-binding site [chemical binding]; other site 407148004420 ATP-binding [chemical binding]; other site 407148004421 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 407148004422 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 407148004423 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 407148004424 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 407148004425 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 407148004426 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 407148004427 AAA domain; Region: AAA_14; pfam13173 407148004428 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 407148004429 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 407148004430 dimerization interface [polypeptide binding]; other site 407148004431 DPS ferroxidase diiron center [ion binding]; other site 407148004432 ion pore; other site 407148004433 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 407148004434 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 407148004435 active site 407148004436 dimer interface [polypeptide binding]; other site 407148004437 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 407148004438 dimer interface [polypeptide binding]; other site 407148004439 active site 407148004440 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 407148004441 active site 407148004442 tetramer interface; other site 407148004443 acetyl-CoA synthetase; Provisional; Region: PRK00174 407148004444 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 407148004445 active site 407148004446 CoA binding site [chemical binding]; other site 407148004447 acyl-activating enzyme (AAE) consensus motif; other site 407148004448 AMP binding site [chemical binding]; other site 407148004449 acetate binding site [chemical binding]; other site 407148004450 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 407148004451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 407148004452 Walker A/P-loop; other site 407148004453 ATP binding site [chemical binding]; other site 407148004454 Q-loop/lid; other site 407148004455 ABC transporter signature motif; other site 407148004456 Walker B; other site 407148004457 D-loop; other site 407148004458 H-loop/switch region; other site 407148004459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148004460 dimer interface [polypeptide binding]; other site 407148004461 conserved gate region; other site 407148004462 putative PBP binding loops; other site 407148004463 ABC-ATPase subunit interface; other site 407148004464 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 407148004465 PBP superfamily domain; Region: PBP_like_2; pfam12849 407148004466 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 407148004467 putative active site [active] 407148004468 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 407148004469 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 407148004470 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 407148004471 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 407148004472 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 407148004473 Predicted transcriptional regulators [Transcription]; Region: COG1733 407148004474 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 407148004475 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 407148004476 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 407148004477 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 407148004478 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 407148004479 putative NAD(P) binding site [chemical binding]; other site 407148004480 putative substrate binding site [chemical binding]; other site 407148004481 catalytic Zn binding site [ion binding]; other site 407148004482 structural Zn binding site [ion binding]; other site 407148004483 dimer interface [polypeptide binding]; other site 407148004484 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 407148004485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 407148004486 DEAD-like helicases superfamily; Region: DEXDc; smart00487 407148004487 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 407148004488 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 407148004489 putative Mg++ binding site [ion binding]; other site 407148004490 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 407148004491 AAA domain; Region: AAA_21; pfam13304 407148004492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 407148004493 Q-loop/lid; other site 407148004494 ABC transporter signature motif; other site 407148004495 Walker B; other site 407148004496 D-loop; other site 407148004497 H-loop/switch region; other site 407148004498 RloB-like protein; Region: RloB; pfam13707 407148004499 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 407148004500 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 407148004501 HsdM N-terminal domain; Region: HsdM_N; pfam12161 407148004502 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 407148004503 Methyltransferase domain; Region: Methyltransf_26; pfam13659 407148004504 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 407148004505 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 407148004506 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 407148004507 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 407148004508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148004509 putative substrate translocation pore; other site 407148004510 Predicted permease; Region: DUF318; cl17795 407148004511 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 407148004512 dimerization interface [polypeptide binding]; other site 407148004513 putative DNA binding site [nucleotide binding]; other site 407148004514 putative Zn2+ binding site [ion binding]; other site 407148004515 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 407148004516 Low molecular weight phosphatase family; Region: LMWPc; cl00105 407148004517 active site 407148004518 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 407148004519 Sodium Bile acid symporter family; Region: SBF; cl17470 407148004520 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 407148004521 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 407148004522 DNA binding residues [nucleotide binding] 407148004523 putative dimer interface [polypeptide binding]; other site 407148004524 Cache domain; Region: Cache_1; pfam02743 407148004525 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 407148004526 dimer interface [polypeptide binding]; other site 407148004527 putative CheW interface [polypeptide binding]; other site 407148004528 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15490 407148004529 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 407148004530 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 407148004531 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 407148004532 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 407148004533 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 407148004534 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 407148004535 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 407148004536 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713 407148004537 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 407148004538 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 407148004539 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 407148004540 4Fe-4S binding domain; Region: Fer4; cl02805 407148004541 4Fe-4S binding domain; Region: Fer4; pfam00037 407148004542 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 407148004543 NADH dehydrogenase subunit G; Validated; Region: PRK08493 407148004544 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 407148004545 catalytic loop [active] 407148004546 iron binding site [ion binding]; other site 407148004547 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 407148004548 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 407148004549 NADH dehydrogenase subunit D; Validated; Region: PRK06075 407148004550 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 407148004551 NADH dehydrogenase subunit C; Provisional; Region: PRK08491 407148004552 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 407148004553 NADH dehydrogenase subunit B; Validated; Region: PRK06411 407148004554 NADH dehydrogenase subunit A; Validated; Region: PRK08489 407148004555 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 407148004556 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 407148004557 Walker A/P-loop; other site 407148004558 ATP binding site [chemical binding]; other site 407148004559 Q-loop/lid; other site 407148004560 ABC transporter signature motif; other site 407148004561 Walker B; other site 407148004562 D-loop; other site 407148004563 H-loop/switch region; other site 407148004564 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 407148004565 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 407148004566 Walker A/P-loop; other site 407148004567 ATP binding site [chemical binding]; other site 407148004568 Q-loop/lid; other site 407148004569 ABC transporter signature motif; other site 407148004570 Walker B; other site 407148004571 D-loop; other site 407148004572 H-loop/switch region; other site 407148004573 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 407148004574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148004575 putative PBP binding loops; other site 407148004576 ABC-ATPase subunit interface; other site 407148004577 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 407148004578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 407148004579 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 407148004580 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 407148004581 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 407148004582 molybdopterin cofactor binding site; other site 407148004583 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 407148004584 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 407148004585 molybdopterin cofactor binding site; other site 407148004586 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 407148004587 4Fe-4S binding domain; Region: Fer4; pfam00037 407148004588 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 407148004589 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 407148004590 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 407148004591 heme-binding site [chemical binding]; other site 407148004592 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 407148004593 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 407148004594 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 407148004595 Walker A/P-loop; other site 407148004596 ATP binding site [chemical binding]; other site 407148004597 Q-loop/lid; other site 407148004598 ABC transporter signature motif; other site 407148004599 Walker B; other site 407148004600 D-loop; other site 407148004601 H-loop/switch region; other site 407148004602 metabolite-proton symporter; Region: 2A0106; TIGR00883 407148004603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148004604 putative substrate translocation pore; other site 407148004605 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 407148004606 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 407148004607 rRNA binding site [nucleotide binding]; other site 407148004608 predicted 30S ribosome binding site; other site 407148004609 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 407148004610 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 407148004611 30S ribosomal protein S13; Region: bact_S13; TIGR03631 407148004612 30S ribosomal protein S11; Validated; Region: PRK05309 407148004613 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 407148004614 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 407148004615 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 407148004616 RNA binding surface [nucleotide binding]; other site 407148004617 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 407148004618 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 407148004619 alphaNTD homodimer interface [polypeptide binding]; other site 407148004620 alphaNTD - beta interaction site [polypeptide binding]; other site 407148004621 alphaNTD - beta' interaction site [polypeptide binding]; other site 407148004622 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 407148004623 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 407148004624 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 407148004625 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 407148004626 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 407148004627 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 407148004628 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 407148004629 NAD binding site [chemical binding]; other site 407148004630 dimerization interface [polypeptide binding]; other site 407148004631 product binding site; other site 407148004632 substrate binding site [chemical binding]; other site 407148004633 zinc binding site [ion binding]; other site 407148004634 catalytic residues [active] 407148004635 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 407148004636 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 407148004637 active site 407148004638 motif I; other site 407148004639 motif II; other site 407148004640 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 407148004641 putative active site pocket [active] 407148004642 4-fold oligomerization interface [polypeptide binding]; other site 407148004643 metal binding residues [ion binding]; metal-binding site 407148004644 3-fold/trimer interface [polypeptide binding]; other site 407148004645 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 407148004646 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 407148004647 putative active site [active] 407148004648 oxyanion strand; other site 407148004649 catalytic triad [active] 407148004650 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 407148004651 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 407148004652 catalytic residues [active] 407148004653 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 407148004654 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 407148004655 substrate binding site [chemical binding]; other site 407148004656 glutamase interaction surface [polypeptide binding]; other site 407148004657 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 407148004658 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 407148004659 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 407148004660 metal binding site [ion binding]; metal-binding site 407148004661 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 407148004662 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 407148004663 putative trimer interface [polypeptide binding]; other site 407148004664 putative CoA binding site [chemical binding]; other site 407148004665 antiporter inner membrane protein; Provisional; Region: PRK11670 407148004666 Domain of unknown function DUF59; Region: DUF59; pfam01883 407148004667 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 407148004668 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 407148004669 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 407148004670 substrate binding site; other site 407148004671 dimer interface; other site 407148004672 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 407148004673 homotrimer interaction site [polypeptide binding]; other site 407148004674 zinc binding site [ion binding]; other site 407148004675 CDP-binding sites; other site 407148004676 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 407148004677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 407148004678 active site 407148004679 intermolecular recognition site; other site 407148004680 dimerization interface [polypeptide binding]; other site 407148004681 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046 407148004682 ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747 407148004683 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 407148004684 tetramer interfaces [polypeptide binding]; other site 407148004685 binuclear metal-binding site [ion binding]; other site 407148004686 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 407148004687 peptide chain release factor 1; Validated; Region: prfA; PRK00591 407148004688 This domain is found in peptide chain release factors; Region: PCRF; smart00937 407148004689 RF-1 domain; Region: RF-1; pfam00472 407148004690 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 407148004691 heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109 407148004692 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 407148004693 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 407148004694 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 407148004695 N-terminal plug; other site 407148004696 ligand-binding site [chemical binding]; other site 407148004697 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 407148004698 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 407148004699 ABC-ATPase subunit interface; other site 407148004700 dimer interface [polypeptide binding]; other site 407148004701 putative PBP binding regions; other site 407148004702 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 407148004703 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 407148004704 Walker A/P-loop; other site 407148004705 ATP binding site [chemical binding]; other site 407148004706 Q-loop/lid; other site 407148004707 ABC transporter signature motif; other site 407148004708 Walker B; other site 407148004709 D-loop; other site 407148004710 H-loop/switch region; other site 407148004711 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 407148004712 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 407148004713 putative binding site residues; other site 407148004714 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 407148004715 FeS/SAM binding site; other site 407148004716 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 407148004717 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 407148004718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148004719 putative substrate translocation pore; other site 407148004720 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 407148004721 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 407148004722 minor groove reading motif; other site 407148004723 helix-hairpin-helix signature motif; other site 407148004724 substrate binding pocket [chemical binding]; other site 407148004725 active site 407148004726 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 407148004727 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 407148004728 nudix motif; other site 407148004729 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 407148004730 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 407148004731 catalytic motif [active] 407148004732 Zn binding site [ion binding]; other site 407148004733 RibD C-terminal domain; Region: RibD_C; cl17279 407148004734 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 407148004735 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 407148004736 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 407148004737 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 407148004738 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 407148004739 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 407148004740 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 407148004741 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 407148004742 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 407148004743 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 407148004744 TonB system transport protein ExbD, group 2; Region: ExbD_2; TIGR02804 407148004745 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 407148004746 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 407148004747 Protein of unknown function (DUF3135); Region: DUF3135; pfam11333 407148004748 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 407148004749 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 407148004750 Ligand Binding Site [chemical binding]; other site 407148004751 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 407148004752 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 407148004753 Tetramer interface [polypeptide binding]; other site 407148004754 active site 407148004755 FMN-binding site [chemical binding]; other site 407148004756 ribonuclease III; Reviewed; Region: rnc; PRK00102 407148004757 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 407148004758 dimerization interface [polypeptide binding]; other site 407148004759 active site 407148004760 metal binding site [ion binding]; metal-binding site 407148004761 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 407148004762 dsRNA binding site [nucleotide binding]; other site 407148004763 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 407148004764 RNA/DNA hybrid binding site [nucleotide binding]; other site 407148004765 active site 407148004766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 407148004767 TPR motif; other site 407148004768 binding surface 407148004769 Tetratricopeptide repeat; Region: TPR_16; pfam13432 407148004770 Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have...; Region: ZZ; cl00295 407148004771 Zinc-binding sites [ion binding]; other site 407148004772 zinc cluster 1 [ion binding]; other site 407148004773 putative charged binding surface; other site 407148004774 putative hydrophobic binding surface; other site 407148004775 zinc cluster 2 [ion binding]; other site 407148004776 DNA primase, catalytic core; Region: dnaG; TIGR01391 407148004777 CHC2 zinc finger; Region: zf-CHC2; pfam01807 407148004778 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 407148004779 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 407148004780 active site 407148004781 metal binding site [ion binding]; metal-binding site 407148004782 interdomain interaction site; other site 407148004783 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 407148004784 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 407148004785 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 407148004786 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 407148004787 hypothetical protein; Provisional; Region: PRK03762 407148004788 PDZ domain; Region: PDZ_2; pfam13180 407148004789 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 407148004790 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 407148004791 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 407148004792 substrate binding pocket [chemical binding]; other site 407148004793 chain length determination region; other site 407148004794 substrate-Mg2+ binding site; other site 407148004795 catalytic residues [active] 407148004796 aspartate-rich region 1; other site 407148004797 active site lid residues [active] 407148004798 aspartate-rich region 2; other site 407148004799 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 407148004800 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 407148004801 TPP-binding site [chemical binding]; other site 407148004802 dimer interface [polypeptide binding]; other site 407148004803 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 407148004804 PYR/PP interface [polypeptide binding]; other site 407148004805 dimer interface [polypeptide binding]; other site 407148004806 TPP binding site [chemical binding]; other site 407148004807 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 407148004808 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 407148004809 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 407148004810 Permease; Region: Permease; pfam02405 407148004811 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 407148004812 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 407148004813 Walker A/P-loop; other site 407148004814 ATP binding site [chemical binding]; other site 407148004815 Q-loop/lid; other site 407148004816 ABC transporter signature motif; other site 407148004817 Walker B; other site 407148004818 D-loop; other site 407148004819 H-loop/switch region; other site 407148004820 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 407148004821 mce related protein; Region: MCE; pfam02470 407148004822 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 407148004823 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 407148004824 active site 407148004825 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 407148004826 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 407148004827 NlpC/P60 family; Region: NLPC_P60; pfam00877 407148004828 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 407148004829 Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004 407148004830 Putative motility protein; Region: YjfB_motility; pfam14070 407148004831 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 407148004832 Predicted membrane protein [Function unknown]; Region: COG4280 407148004833 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 407148004834 Predicted membrane protein [Function unknown]; Region: COG4393 407148004835 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 407148004836 Uncharacterized conserved protein [Function unknown]; Region: COG3350 407148004837 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 407148004838 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 407148004839 FtsX-like permease family; Region: FtsX; pfam02687 407148004840 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 407148004841 FtsX-like permease family; Region: FtsX; pfam02687 407148004842 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 407148004843 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 407148004844 Walker A/P-loop; other site 407148004845 ATP binding site [chemical binding]; other site 407148004846 Q-loop/lid; other site 407148004847 ABC transporter signature motif; other site 407148004848 Walker B; other site 407148004849 D-loop; other site 407148004850 H-loop/switch region; other site 407148004851 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 407148004852 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 407148004853 catalytic residues [active] 407148004854 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 407148004855 Predicted metal-binding protein [General function prediction only]; Region: COG3019 407148004856 DNA ligase; Provisional; Region: PRK09125 407148004857 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 407148004858 DNA binding site [nucleotide binding] 407148004859 active site 407148004860 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 407148004861 DNA binding site [nucleotide binding] 407148004862 AMIN domain; Region: AMIN; pfam11741 407148004863 enolase; Provisional; Region: eno; PRK00077 407148004864 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 407148004865 dimer interface [polypeptide binding]; other site 407148004866 metal binding site [ion binding]; metal-binding site 407148004867 substrate binding pocket [chemical binding]; other site 407148004868 recombinase A; Provisional; Region: recA; PRK09354 407148004869 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 407148004870 hexamer interface [polypeptide binding]; other site 407148004871 Walker A motif; other site 407148004872 ATP binding site [chemical binding]; other site 407148004873 Walker B motif; other site 407148004874 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 407148004875 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 407148004876 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 407148004877 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 407148004878 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 407148004879 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 407148004880 active site 407148004881 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 407148004882 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 407148004883 dimer interface [polypeptide binding]; other site 407148004884 active site 407148004885 citrylCoA binding site [chemical binding]; other site 407148004886 NADH binding [chemical binding]; other site 407148004887 cationic pore residues; other site 407148004888 oxalacetate/citrate binding site [chemical binding]; other site 407148004889 coenzyme A binding site [chemical binding]; other site 407148004890 catalytic triad [active] 407148004891 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 407148004892 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 407148004893 biotin synthase; Provisional; Region: PRK08508 407148004894 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 407148004895 FeS/SAM binding site; other site 407148004896 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 407148004897 DNA topoisomerase I; Validated; Region: PRK05582 407148004898 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 407148004899 active site 407148004900 interdomain interaction site; other site 407148004901 putative metal-binding site [ion binding]; other site 407148004902 nucleotide binding site [chemical binding]; other site 407148004903 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 407148004904 domain I; other site 407148004905 DNA binding groove [nucleotide binding] 407148004906 phosphate binding site [ion binding]; other site 407148004907 domain II; other site 407148004908 domain III; other site 407148004909 nucleotide binding site [chemical binding]; other site 407148004910 catalytic site [active] 407148004911 domain IV; other site 407148004912 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 407148004913 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 407148004914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 407148004915 putative substrate translocation pore; other site 407148004916 Major Facilitator Superfamily; Region: MFS_1; pfam07690 407148004917 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 407148004918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 407148004919 Walker A/P-loop; other site 407148004920 ATP binding site [chemical binding]; other site 407148004921 Q-loop/lid; other site 407148004922 ABC transporter signature motif; other site 407148004923 Walker B; other site 407148004924 D-loop; other site 407148004925 H-loop/switch region; other site 407148004926 TOBE domain; Region: TOBE_2; pfam08402 407148004927 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 407148004928 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 407148004929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 407148004930 dimer interface [polypeptide binding]; other site 407148004931 conserved gate region; other site 407148004932 putative PBP binding loops; other site 407148004933 ABC-ATPase subunit interface; other site 407148004934 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 407148004935 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 407148004936 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 407148004937 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 407148004938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 407148004939 motif I; other site 407148004940 active site 407148004941 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 407148004942 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 407148004943 active site 407148004944 metal binding site [ion binding]; metal-binding site 407148004945 hexamer interface [polypeptide binding]; other site 407148004946 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 407148004947 SecY translocase; Region: SecY; pfam00344 407148004948 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 407148004949 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 407148004950 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 407148004951 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 407148004952 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 407148004953 5S rRNA interface [nucleotide binding]; other site 407148004954 23S rRNA interface [nucleotide binding]; other site 407148004955 L5 interface [polypeptide binding]; other site 407148004956 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 407148004957 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 407148004958 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 407148004959 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 407148004960 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 407148004961 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 407148004962 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 407148004963 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 407148004964 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 407148004965 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 407148004966 RNA binding site [nucleotide binding]; other site 407148004967 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 407148004968 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 407148004969 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 407148004970 putative translocon interaction site; other site 407148004971 23S rRNA interface [nucleotide binding]; other site 407148004972 signal recognition particle (SRP54) interaction site; other site 407148004973 L23 interface [polypeptide binding]; other site 407148004974 trigger factor interaction site; other site 407148004975 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 407148004976 23S rRNA interface [nucleotide binding]; other site 407148004977 5S rRNA interface [nucleotide binding]; other site 407148004978 putative antibiotic binding site [chemical binding]; other site 407148004979 L25 interface [polypeptide binding]; other site 407148004980 L27 interface [polypeptide binding]; other site 407148004981 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 407148004982 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 407148004983 G-X-X-G motif; other site 407148004984 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 407148004985 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 407148004986 putative translocon binding site; other site 407148004987 protein-rRNA interface [nucleotide binding]; other site 407148004988 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 407148004989 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 407148004990 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 407148004991 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 407148004992 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 407148004993 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 407148004994 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 407148004995 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 407148004996 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 407148004997 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 407148004998 RNA binding surface [nucleotide binding]; other site 407148004999 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 407148005000 active site 407148005001 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 407148005002 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 407148005003 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 407148005004 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 407148005005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 407148005006 S-adenosylmethionine binding site [chemical binding]; other site 407148005007 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 407148005008 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 407148005009 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 407148005010 FeS/SAM binding site; other site 407148005011 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 407148005012 FeS/SAM binding site; other site 407148005013 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 407148005014 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 407148005015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 407148005016 Coenzyme A binding pocket [chemical binding]; other site 407148005017 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 407148005018 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 407148005019 substrate binding site [chemical binding]; other site 407148005020 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 407148005021 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 407148005022 substrate binding site [chemical binding]; other site 407148005023 ligand binding site [chemical binding]; other site 407148005024 tartrate dehydrogenase; Region: TTC; TIGR02089 407148005025 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 407148005026 2-isopropylmalate synthase; Validated; Region: PRK00915 407148005027 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 407148005028 active site 407148005029 catalytic residues [active] 407148005030 metal binding site [ion binding]; metal-binding site 407148005031 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 407148005032 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 407148005033 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 407148005034 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 407148005035 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 407148005036 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 407148005037 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 407148005038 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 407148005039 active site 407148005040 putative DNA-binding cleft [nucleotide binding]; other site 407148005041 dimer interface [polypeptide binding]; other site