-- dump date 20140619_021756 -- class Genbank::misc_feature -- table misc_feature_note -- id note 567106000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 567106000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106000003 Walker A motif; other site 567106000004 ATP binding site [chemical binding]; other site 567106000005 Walker B motif; other site 567106000006 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 567106000007 DnaA box-binding interface [nucleotide binding]; other site 567106000008 DNA polymerase III subunit beta; Validated; Region: PRK05643 567106000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 567106000010 putative DNA binding surface [nucleotide binding]; other site 567106000011 dimer interface [polypeptide binding]; other site 567106000012 beta-clamp/clamp loader binding surface; other site 567106000013 beta-clamp/translesion DNA polymerase binding surface; other site 567106000014 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 567106000015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 567106000016 Mg2+ binding site [ion binding]; other site 567106000017 G-X-G motif; other site 567106000018 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 567106000019 anchoring element; other site 567106000020 dimer interface [polypeptide binding]; other site 567106000021 ATP binding site [chemical binding]; other site 567106000022 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 567106000023 active site 567106000024 putative metal-binding site [ion binding]; other site 567106000025 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 567106000026 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 567106000027 sulfite oxidase; Provisional; Region: PLN00177 567106000028 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 567106000029 Moco binding site; other site 567106000030 metal coordination site [ion binding]; other site 567106000031 dimerization interface [polypeptide binding]; other site 567106000032 Predicted permease [General function prediction only]; Region: COG2056 567106000033 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 567106000034 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 567106000035 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 567106000036 active site 567106000037 dimer interface [polypeptide binding]; other site 567106000038 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 567106000039 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 567106000040 active site 567106000041 FMN binding site [chemical binding]; other site 567106000042 substrate binding site [chemical binding]; other site 567106000043 3Fe-4S cluster binding site [ion binding]; other site 567106000044 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 567106000045 domain interface; other site 567106000046 Protein of unknown function DUF262; Region: DUF262; pfam03235 567106000047 Uncharacterized conserved protein [Function unknown]; Region: COG1479 567106000048 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 567106000049 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 567106000050 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 567106000051 RNA/DNA hybrid binding site [nucleotide binding]; other site 567106000052 active site 567106000053 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 567106000054 Helix-hairpin-helix motif; Region: HHH; pfam00633 567106000055 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 567106000056 non-heme iron binding site [ion binding]; other site 567106000057 dimer interface [polypeptide binding]; other site 567106000058 Rubrerythrin [Energy production and conversion]; Region: COG1592 567106000059 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 567106000060 binuclear metal center [ion binding]; other site 567106000061 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 567106000062 iron binding site [ion binding]; other site 567106000063 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 567106000064 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 567106000065 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 567106000066 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 567106000067 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 567106000068 Ligand Binding Site [chemical binding]; other site 567106000069 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 567106000070 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 567106000071 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 567106000072 dimer interface [polypeptide binding]; other site 567106000073 putative CheW interface [polypeptide binding]; other site 567106000074 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 567106000075 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 567106000076 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 567106000077 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 567106000078 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 567106000079 active site 567106000080 adenylosuccinate lyase; Provisional; Region: PRK08470 567106000081 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 567106000082 tetramer interface [polypeptide binding]; other site 567106000083 active site 567106000084 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 567106000085 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 567106000086 ATP cone domain; Region: ATP-cone; pfam03477 567106000087 Class I ribonucleotide reductase; Region: RNR_I; cd01679 567106000088 active site 567106000089 dimer interface [polypeptide binding]; other site 567106000090 catalytic residues [active] 567106000091 effector binding site; other site 567106000092 R2 peptide binding site; other site 567106000093 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 567106000094 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 567106000095 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 567106000096 CTP synthetase; Validated; Region: pyrG; PRK05380 567106000097 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 567106000098 Catalytic site [active] 567106000099 active site 567106000100 UTP binding site [chemical binding]; other site 567106000101 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 567106000102 active site 567106000103 putative oxyanion hole; other site 567106000104 catalytic triad [active] 567106000105 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 567106000106 DHH family; Region: DHH; pfam01368 567106000107 DHHA1 domain; Region: DHHA1; pfam02272 567106000108 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 567106000109 active site 567106000110 homodimer interface [polypeptide binding]; other site 567106000111 homotetramer interface [polypeptide binding]; other site 567106000112 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 567106000113 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 567106000114 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 567106000115 Methyltransferase domain; Region: Methyltransf_26; pfam13659 567106000116 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 567106000117 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 567106000118 AAA domain; Region: AAA_13; pfam13166 567106000119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 567106000120 ABC transporter signature motif; other site 567106000121 Walker B; other site 567106000122 D-loop; other site 567106000123 H-loop/switch region; other site 567106000124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 567106000125 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 567106000126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106000127 putative substrate translocation pore; other site 567106000128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 567106000129 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 567106000130 Cytochrome c [Energy production and conversion]; Region: COG3258 567106000131 Cytochrome c; Region: Cytochrom_C; pfam00034 567106000132 Cytochrome c; Region: Cytochrom_C; pfam00034 567106000133 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 567106000134 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 567106000135 G1 box; other site 567106000136 putative GEF interaction site [polypeptide binding]; other site 567106000137 GTP/Mg2+ binding site [chemical binding]; other site 567106000138 Switch I region; other site 567106000139 G2 box; other site 567106000140 G3 box; other site 567106000141 Switch II region; other site 567106000142 G4 box; other site 567106000143 G5 box; other site 567106000144 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 567106000145 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 567106000146 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 567106000147 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 567106000148 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 567106000149 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 567106000150 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 567106000151 Protein of unknown function (DUF342); Region: DUF342; pfam03961 567106000152 Hemerythrin; Region: Hemerythrin; cd12107 567106000153 Fe binding site [ion binding]; other site 567106000154 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 567106000155 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 567106000156 Ligand Binding Site [chemical binding]; other site 567106000157 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 567106000158 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 567106000159 putative active site [active] 567106000160 flagellar motor switch protein FliY; Validated; Region: PRK08432 567106000161 flagellar motor switch protein FliN; Region: fliN; TIGR02480 567106000162 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 567106000163 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 567106000164 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 567106000165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 567106000166 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 567106000167 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 567106000168 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 567106000169 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 567106000170 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 567106000171 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 567106000172 catalytic center binding site [active] 567106000173 ATP binding site [chemical binding]; other site 567106000174 Dehydroquinase class II; Region: DHquinase_II; pfam01220 567106000175 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 567106000176 trimer interface [polypeptide binding]; other site 567106000177 active site 567106000178 dimer interface [polypeptide binding]; other site 567106000179 chlorohydrolase; Provisional; Region: PRK08418 567106000180 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 567106000181 active site 567106000182 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 567106000183 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 567106000184 tandem repeat interface [polypeptide binding]; other site 567106000185 oligomer interface [polypeptide binding]; other site 567106000186 active site residues [active] 567106000187 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 567106000188 Hemerythrin family; Region: Hemerythrin-like; cl15774 567106000189 Hemerythrin; Region: Hemerythrin; cd12107 567106000190 Uncharacterized conserved protein [Function unknown]; Region: COG1556 567106000191 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 567106000192 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 567106000193 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 567106000194 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 567106000195 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 567106000196 Cysteine-rich domain; Region: CCG; pfam02754 567106000197 Cysteine-rich domain; Region: CCG; pfam02754 567106000198 L-lactate permease; Region: Lactate_perm; cl00701 567106000199 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 567106000200 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 567106000201 CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081 567106000202 putative catalytic site [active] 567106000203 CdtC interface [polypeptide binding]; other site 567106000204 heterotrimer interface [polypeptide binding]; other site 567106000205 CdtA interface [polypeptide binding]; other site 567106000206 putative metal binding site [ion binding]; other site 567106000207 putative phosphate binding site [ion binding]; other site 567106000208 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 567106000209 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 567106000210 putative sugar binding sites [chemical binding]; other site 567106000211 Q-X-W motif; other site 567106000212 Cytochrome bd-type quinol oxidase, subunit 1 [Energy production and conversion]; Region: CydA; COG1271 567106000213 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 567106000214 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 567106000215 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 567106000216 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 567106000217 aspartate racemase; Region: asp_race; TIGR00035 567106000218 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 567106000219 ligand binding site [chemical binding]; other site 567106000220 active site 567106000221 UGI interface [polypeptide binding]; other site 567106000222 catalytic site [active] 567106000223 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 567106000224 Aspartase; Region: Aspartase; cd01357 567106000225 active sites [active] 567106000226 tetramer interface [polypeptide binding]; other site 567106000227 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 567106000228 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 567106000229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 567106000230 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 567106000231 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 567106000232 putative dimer interface [polypeptide binding]; other site 567106000233 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 567106000234 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 567106000235 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 567106000236 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 567106000237 GTPase CgtA; Reviewed; Region: obgE; PRK12299 567106000238 GTP1/OBG; Region: GTP1_OBG; pfam01018 567106000239 Obg GTPase; Region: Obg; cd01898 567106000240 G1 box; other site 567106000241 GTP/Mg2+ binding site [chemical binding]; other site 567106000242 Switch I region; other site 567106000243 G2 box; other site 567106000244 G3 box; other site 567106000245 Switch II region; other site 567106000246 G4 box; other site 567106000247 G5 box; other site 567106000248 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 567106000249 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 567106000250 nucleotide binding site [chemical binding]; other site 567106000251 homotetrameric interface [polypeptide binding]; other site 567106000252 putative phosphate binding site [ion binding]; other site 567106000253 putative allosteric binding site; other site 567106000254 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 567106000255 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 567106000256 putative active site [active] 567106000257 substrate binding site [chemical binding]; other site 567106000258 putative cosubstrate binding site; other site 567106000259 catalytic site [active] 567106000260 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 567106000261 substrate binding site [chemical binding]; other site 567106000262 biotin--protein ligase; Provisional; Region: PRK08477 567106000263 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 567106000264 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 567106000265 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 567106000266 P-loop; other site 567106000267 Magnesium ion binding site [ion binding]; other site 567106000268 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 567106000269 Magnesium ion binding site [ion binding]; other site 567106000270 ParB-like nuclease domain; Region: ParB; smart00470 567106000271 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 567106000272 F0F1 ATP synthase subunit B'; Validated; Region: PRK08476 567106000273 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 567106000274 F0F1 ATP synthase subunit B; Validated; Region: PRK08475 567106000275 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 567106000276 F0F1 ATP synthase subunit delta; Validated; Region: PRK08474 567106000277 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 567106000278 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 567106000279 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 567106000280 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 567106000281 beta subunit interaction interface [polypeptide binding]; other site 567106000282 Walker A motif; other site 567106000283 ATP binding site [chemical binding]; other site 567106000284 Walker B motif; other site 567106000285 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 567106000286 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 567106000287 core domain interface [polypeptide binding]; other site 567106000288 delta subunit interface [polypeptide binding]; other site 567106000289 epsilon subunit interface [polypeptide binding]; other site 567106000290 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 567106000291 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 567106000292 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 567106000293 alpha subunit interaction interface [polypeptide binding]; other site 567106000294 Walker A motif; other site 567106000295 ATP binding site [chemical binding]; other site 567106000296 Walker B motif; other site 567106000297 inhibitor binding site; inhibition site 567106000298 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 567106000299 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 567106000300 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 567106000301 gamma subunit interface [polypeptide binding]; other site 567106000302 epsilon subunit interface [polypeptide binding]; other site 567106000303 LBP interface [polypeptide binding]; other site 567106000304 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 567106000305 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 567106000306 TolR protein; Region: tolR; TIGR02801 567106000307 TonB C terminal; Region: TonB_2; pfam13103 567106000308 translocation protein TolB; Provisional; Region: tolB; PRK04043 567106000309 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 567106000310 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 567106000311 ligand binding site [chemical binding]; other site 567106000312 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 567106000313 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 567106000314 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 567106000315 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 567106000316 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 567106000317 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 567106000318 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 567106000319 Ligand Binding Site [chemical binding]; other site 567106000320 Isochorismatase family; Region: Isochorismatase; pfam00857 567106000321 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 567106000322 catalytic triad [active] 567106000323 conserved cis-peptide bond; other site 567106000324 putative recombination protein RecO; Provisional; Region: PRK13908 567106000325 metal-binding heat shock protein; Provisional; Region: PRK00016 567106000326 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 567106000327 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 567106000328 FMN binding site [chemical binding]; other site 567106000329 active site 567106000330 catalytic residues [active] 567106000331 substrate binding site [chemical binding]; other site 567106000332 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 567106000333 Uncharacterized conserved protein [Function unknown]; Region: COG1576 567106000334 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 567106000335 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 567106000336 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 567106000337 Putative fructose-1,6-bisphosphatase or related enzymes of inositol monophosphatase family. These are Mg++ dependent phosphatases. Members in this family may have fructose-1,6-bisphosphatase and/or inositol-monophosphatase activity. Fructose-1; Region: Arch_FBPase_2; cd01642 567106000338 putative active site [active] 567106000339 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 567106000340 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 567106000341 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 567106000342 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 567106000343 Surface antigen; Region: Bac_surface_Ag; pfam01103 567106000344 prephenate dehydrogenase; Validated; Region: PRK08507 567106000345 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 567106000346 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 567106000347 Peptidase family M23; Region: Peptidase_M23; pfam01551 567106000348 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 567106000349 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 567106000350 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 567106000351 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 567106000352 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 567106000353 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 567106000354 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 567106000355 translation initiation factor IF-2; Region: IF-2; TIGR00487 567106000356 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 567106000357 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 567106000358 G1 box; other site 567106000359 putative GEF interaction site [polypeptide binding]; other site 567106000360 GTP/Mg2+ binding site [chemical binding]; other site 567106000361 Switch I region; other site 567106000362 G2 box; other site 567106000363 G3 box; other site 567106000364 Switch II region; other site 567106000365 G4 box; other site 567106000366 G5 box; other site 567106000367 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 567106000368 Translation-initiation factor 2; Region: IF-2; pfam11987 567106000369 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 567106000370 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 567106000371 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 567106000372 Sm and related proteins; Region: Sm_like; cl00259 567106000373 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 567106000374 putative oligomer interface [polypeptide binding]; other site 567106000375 putative RNA binding site [nucleotide binding]; other site 567106000376 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 567106000377 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 567106000378 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 567106000379 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 567106000380 dimer interface [polypeptide binding]; other site 567106000381 putative PBP binding regions; other site 567106000382 ABC-ATPase subunit interface; other site 567106000383 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 567106000384 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 567106000385 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 567106000386 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 567106000387 putative metal binding residues [ion binding]; other site 567106000388 Cache domain; Region: Cache_1; pfam02743 567106000389 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 567106000390 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 567106000391 dimer interface [polypeptide binding]; other site 567106000392 putative CheW interface [polypeptide binding]; other site 567106000393 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 567106000394 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 567106000395 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 567106000396 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 567106000397 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 567106000398 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 567106000399 catalytic residues [active] 567106000400 hypothetical protein; Reviewed; Region: PRK12497 567106000401 homoserine dehydrogenase; Provisional; Region: PRK06349 567106000402 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 567106000403 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 567106000404 aspartate aminotransferase; Provisional; Region: PRK08636 567106000405 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 567106000406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106000407 homodimer interface [polypeptide binding]; other site 567106000408 catalytic residue [active] 567106000409 Helix-turn-helix domain; Region: HTH_25; pfam13413 567106000410 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 567106000411 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 567106000412 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 567106000413 Predicted methyltransferases [General function prediction only]; Region: COG0313 567106000414 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 567106000415 putative SAM binding site [chemical binding]; other site 567106000416 putative homodimer interface [polypeptide binding]; other site 567106000417 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 567106000418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 567106000419 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 567106000420 queuosine biosynthesis protein QueD; Region: queuosine_QueD; TIGR03367 567106000421 active site 567106000422 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 567106000423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 567106000424 FeS/SAM binding site; other site 567106000425 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 567106000426 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 567106000427 FeS/SAM binding site; other site 567106000428 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 567106000429 prenyltransferase; Reviewed; Region: ubiA; PRK12874 567106000430 UbiA prenyltransferase family; Region: UbiA; pfam01040 567106000431 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 567106000432 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 567106000433 Predicted membrane protein [Function unknown]; Region: COG1971 567106000434 Domain of unknown function DUF; Region: DUF204; pfam02659 567106000435 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 567106000436 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 567106000437 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 567106000438 potential frameshift: common BLAST hit: gi|222824541|ref|YP_002576115.1| methyltransferase 567106000439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 567106000440 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 567106000441 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 567106000442 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 567106000443 NAD(P) binding pocket [chemical binding]; other site 567106000444 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 567106000445 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 567106000446 Walker A/P-loop; other site 567106000447 ATP binding site [chemical binding]; other site 567106000448 Q-loop/lid; other site 567106000449 ABC transporter signature motif; other site 567106000450 Walker B; other site 567106000451 D-loop; other site 567106000452 H-loop/switch region; other site 567106000453 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 567106000454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106000455 dimer interface [polypeptide binding]; other site 567106000456 conserved gate region; other site 567106000457 putative PBP binding loops; other site 567106000458 ABC-ATPase subunit interface; other site 567106000459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106000460 dimer interface [polypeptide binding]; other site 567106000461 conserved gate region; other site 567106000462 putative PBP binding loops; other site 567106000463 ABC-ATPase subunit interface; other site 567106000464 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 567106000465 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 567106000466 Uncharacterized iron-regulated protein [Function unknown]; Region: PhuW; COG3016 567106000467 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 567106000468 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 567106000469 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 567106000470 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 567106000471 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 567106000472 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 567106000473 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 567106000474 ABC-type long-chain fatty acid transport system, fused permease and ATPase components [Lipid metabolism]; Region: SbmA; COG1133 567106000475 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 567106000476 Domain of unknown function DUF21; Region: DUF21; pfam01595 567106000477 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 567106000478 Transporter associated domain; Region: CorC_HlyC; smart01091 567106000479 Predicted kinase [General function prediction only]; Region: COG4639 567106000480 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 567106000481 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 567106000482 active site 567106000483 metal binding site [ion binding]; metal-binding site 567106000484 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 567106000485 PhnA protein; Region: PhnA; pfam03831 567106000486 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 567106000487 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 567106000488 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 567106000489 active site 567106000490 substrate binding site [chemical binding]; other site 567106000491 cosubstrate binding site; other site 567106000492 catalytic site [active] 567106000493 Uncharacterized conserved protein [Function unknown]; Region: COG0062 567106000494 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 567106000495 putative substrate binding site [chemical binding]; other site 567106000496 putative ATP binding site [chemical binding]; other site 567106000497 Uncharacterized conserved protein [Function unknown]; Region: COG1432 567106000498 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 567106000499 putative metal binding site [ion binding]; other site 567106000500 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 567106000501 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 567106000502 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 567106000503 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 567106000504 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 567106000505 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 567106000506 active site 567106000507 catalytic residues [active] 567106000508 metal binding site [ion binding]; metal-binding site 567106000509 Clp protease; Region: CLP_protease; pfam00574 567106000510 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 567106000511 oligomer interface [polypeptide binding]; other site 567106000512 active site residues [active] 567106000513 trigger factor; Provisional; Region: tig; PRK01490 567106000514 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 567106000515 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 567106000516 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 567106000517 homodecamer interface [polypeptide binding]; other site 567106000518 GTP cyclohydrolase I; Provisional; Region: PLN03044 567106000519 active site 567106000520 putative catalytic site residues [active] 567106000521 zinc binding site [ion binding]; other site 567106000522 GTP-CH-I/GFRP interaction surface; other site 567106000523 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 567106000524 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 567106000525 Walker A motif/ATP binding site; other site 567106000526 Walker B motif; other site 567106000527 amidophosphoribosyltransferase; Provisional; Region: PRK08525 567106000528 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 567106000529 active site 567106000530 tetramer interface [polypeptide binding]; other site 567106000531 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 567106000532 active site 567106000533 dihydrodipicolinate reductase; Provisional; Region: PRK00048 567106000534 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 567106000535 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 567106000536 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 567106000537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106000538 Walker A motif; other site 567106000539 ATP binding site [chemical binding]; other site 567106000540 Walker B motif; other site 567106000541 arginine finger; other site 567106000542 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 567106000543 IS607-like transposase subfamily transposase fragment 567106000544 IS605 family transposase fragment 567106000545 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 567106000546 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 567106000547 G1 box; other site 567106000548 putative GEF interaction site [polypeptide binding]; other site 567106000549 GTP/Mg2+ binding site [chemical binding]; other site 567106000550 Switch I region; other site 567106000551 G2 box; other site 567106000552 G3 box; other site 567106000553 Switch II region; other site 567106000554 G4 box; other site 567106000555 G5 box; other site 567106000556 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 567106000557 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 567106000558 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 567106000559 TnpV fragment 567106000560 Predicted membrane protein [Function unknown]; Region: COG1297 567106000561 putative oligopeptide transporter, OPT family; Region: TIGR00733 567106000562 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 567106000563 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 567106000564 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 567106000565 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 567106000566 active site 567106000567 dimer interface [polypeptide binding]; other site 567106000568 motif 1; other site 567106000569 motif 2; other site 567106000570 motif 3; other site 567106000571 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 567106000572 anticodon binding site; other site 567106000573 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 567106000574 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 567106000575 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 567106000576 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 567106000577 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 567106000578 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 567106000579 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 567106000580 putative acetyltransferase YhhY; Provisional; Region: PRK10140 567106000581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 567106000582 Coenzyme A binding pocket [chemical binding]; other site 567106000583 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 567106000584 feedback inhibition sensing region; other site 567106000585 homohexameric interface [polypeptide binding]; other site 567106000586 nucleotide binding site [chemical binding]; other site 567106000587 N-acetyl-L-glutamate binding site [chemical binding]; other site 567106000588 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 567106000589 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 567106000590 inhibitor-cofactor binding pocket; inhibition site 567106000591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106000592 catalytic residue [active] 567106000593 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 567106000594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106000595 S-adenosylmethionine binding site [chemical binding]; other site 567106000596 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 567106000597 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 567106000598 trimer interface [polypeptide binding]; other site 567106000599 putative metal binding site [ion binding]; other site 567106000600 putative nicotinate phosphoribosyltransferase; Region: NAPRTase_put; TIGR01513 567106000601 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 567106000602 active site 567106000603 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 567106000604 dimer interface [polypeptide binding]; other site 567106000605 putative radical transfer pathway; other site 567106000606 diiron center [ion binding]; other site 567106000607 tyrosyl radical; other site 567106000608 RDD family; Region: RDD; pfam06271 567106000609 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 567106000610 active site 567106000611 ribosome recycling factor; Reviewed; Region: frr; PRK00083 567106000612 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 567106000613 hinge region; other site 567106000614 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 567106000615 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 567106000616 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 567106000617 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 567106000618 active site clefts [active] 567106000619 zinc binding site [ion binding]; other site 567106000620 dimer interface [polypeptide binding]; other site 567106000621 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 567106000622 Mechanosensitive ion channel; Region: MS_channel; pfam00924 567106000623 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 567106000624 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 567106000625 trimerization site [polypeptide binding]; other site 567106000626 active site 567106000627 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 567106000628 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 567106000629 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 567106000630 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 567106000631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 567106000632 catalytic residue [active] 567106000633 Hemerythrin; Region: Hemerythrin; cd12107 567106000634 Fe binding site [ion binding]; other site 567106000635 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 567106000636 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 567106000637 23S rRNA binding site [nucleotide binding]; other site 567106000638 L21 binding site [polypeptide binding]; other site 567106000639 L13 binding site [polypeptide binding]; other site 567106000640 FIST C domain; Region: FIST_C; pfam10442 567106000641 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 567106000642 dimer interface [polypeptide binding]; other site 567106000643 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 567106000644 putative CheW interface [polypeptide binding]; other site 567106000645 FIST N domain; Region: FIST; cl10701 567106000646 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 567106000647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106000648 metabolite-proton symporter; Region: 2A0106; TIGR00883 567106000649 putative substrate translocation pore; other site 567106000650 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 567106000651 trimer interface [polypeptide binding]; other site 567106000652 dimer interface [polypeptide binding]; other site 567106000653 putative active site [active] 567106000654 Protein of unknown function (DUF493); Region: DUF493; pfam04359 567106000655 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 567106000656 putative catalytic site [active] 567106000657 putative metal binding site [ion binding]; other site 567106000658 putative phosphate binding site [ion binding]; other site 567106000659 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 567106000660 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 567106000661 Sulfatase; Region: Sulfatase; pfam00884 567106000662 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 567106000663 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 567106000664 active site 567106000665 substrate binding pocket [chemical binding]; other site 567106000666 dimer interface [polypeptide binding]; other site 567106000667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106000668 S-adenosylmethionine binding site [chemical binding]; other site 567106000669 Cache domain; Region: Cache_1; pfam02743 567106000670 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 567106000671 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 567106000672 dimer interface [polypeptide binding]; other site 567106000673 putative CheW interface [polypeptide binding]; other site 567106000674 zinc transporter ZupT; Provisional; Region: PRK04201 567106000675 ZIP Zinc transporter; Region: Zip; pfam02535 567106000676 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 567106000677 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 567106000678 molybdopterin cofactor binding site [chemical binding]; other site 567106000679 substrate binding site [chemical binding]; other site 567106000680 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 567106000681 molybdopterin cofactor binding site; other site 567106000682 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 567106000683 Cytochrome c; Region: Cytochrom_C; cl11414 567106000684 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 567106000685 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 567106000686 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 567106000687 SPFH domain / Band 7 family; Region: Band_7; pfam01145 567106000688 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 567106000689 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 567106000690 homodimer interface [polypeptide binding]; other site 567106000691 substrate-cofactor binding pocket; other site 567106000692 catalytic residue [active] 567106000693 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 567106000694 active site 1 [active] 567106000695 dimer interface [polypeptide binding]; other site 567106000696 hexamer interface [polypeptide binding]; other site 567106000697 active site 2 [active] 567106000698 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 567106000699 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 567106000700 catalytic triad [active] 567106000701 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 567106000702 Ligand Binding Site [chemical binding]; other site 567106000703 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 567106000704 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 567106000705 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 567106000706 active site 567106000707 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 567106000708 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 567106000709 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 567106000710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106000711 Walker A motif; other site 567106000712 ATP binding site [chemical binding]; other site 567106000713 Walker B motif; other site 567106000714 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 567106000715 rod shape-determining protein MreB; Provisional; Region: PRK13927 567106000716 MreB and similar proteins; Region: MreB_like; cd10225 567106000717 nucleotide binding site [chemical binding]; other site 567106000718 Mg binding site [ion binding]; other site 567106000719 putative protofilament interaction site [polypeptide binding]; other site 567106000720 RodZ interaction site [polypeptide binding]; other site 567106000721 rod shape-determining protein MreC; Provisional; Region: PRK13922 567106000722 rod shape-determining protein MreC; Region: MreC; pfam04085 567106000723 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 567106000724 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 567106000725 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 567106000726 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 567106000727 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 567106000728 ATP-grasp domain; Region: ATP-grasp_4; cl17255 567106000729 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 567106000730 IMP binding site; other site 567106000731 dimer interface [polypeptide binding]; other site 567106000732 interdomain contacts; other site 567106000733 partial ornithine binding site; other site 567106000734 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 567106000735 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 567106000736 putative active site [active] 567106000737 transaldolase; Provisional; Region: PRK03903 567106000738 catalytic residue [active] 567106000739 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 567106000740 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 567106000741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 567106000742 motif II; other site 567106000743 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 567106000744 putative CheA interaction surface; other site 567106000745 chemotaxis protein CheA; Provisional; Region: PRK10547 567106000746 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 567106000747 putative binding surface; other site 567106000748 active site 567106000749 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 567106000750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 567106000751 ATP binding site [chemical binding]; other site 567106000752 Mg2+ binding site [ion binding]; other site 567106000753 G-X-G motif; other site 567106000754 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 567106000755 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 567106000756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 567106000757 active site 567106000758 phosphorylation site [posttranslational modification] 567106000759 intermolecular recognition site; other site 567106000760 dimerization interface [polypeptide binding]; other site 567106000761 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 567106000762 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 567106000763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 567106000764 active site 567106000765 phosphorylation site [posttranslational modification] 567106000766 intermolecular recognition site; other site 567106000767 dimerization interface [polypeptide binding]; other site 567106000768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2908 567106000769 active site 567106000770 metal binding site [ion binding]; metal-binding site 567106000771 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 567106000772 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 567106000773 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 567106000774 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 567106000775 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 567106000776 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 567106000777 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 567106000778 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 567106000779 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 567106000780 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 567106000781 ATP binding site [chemical binding]; other site 567106000782 substrate interface [chemical binding]; other site 567106000783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 567106000784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 567106000785 Coenzyme A binding pocket [chemical binding]; other site 567106000786 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 567106000787 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 567106000788 tetramerization interface [polypeptide binding]; other site 567106000789 active site 567106000790 pantoate--beta-alanine ligase; Region: panC; TIGR00018 567106000791 Pantoate-beta-alanine ligase; Region: PanC; cd00560 567106000792 active site 567106000793 ATP-binding site [chemical binding]; other site 567106000794 pantoate-binding site; other site 567106000795 HXXH motif; other site 567106000796 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 567106000797 active site 567106000798 oligomerization interface [polypeptide binding]; other site 567106000799 metal binding site [ion binding]; metal-binding site 567106000800 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 567106000801 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 567106000802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 567106000803 Walker A/P-loop; other site 567106000804 ATP binding site [chemical binding]; other site 567106000805 Q-loop/lid; other site 567106000806 ABC transporter signature motif; other site 567106000807 Walker B; other site 567106000808 D-loop; other site 567106000809 H-loop/switch region; other site 567106000810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106000811 dimer interface [polypeptide binding]; other site 567106000812 conserved gate region; other site 567106000813 putative PBP binding loops; other site 567106000814 ABC-ATPase subunit interface; other site 567106000815 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 567106000816 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 567106000817 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 567106000818 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 567106000819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106000820 S-adenosylmethionine binding site [chemical binding]; other site 567106000821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 567106000822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2830 567106000823 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 567106000824 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 567106000825 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 567106000826 catalytic residue [active] 567106000827 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 567106000828 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 567106000829 inhibitor-cofactor binding pocket; inhibition site 567106000830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106000831 catalytic residue [active] 567106000832 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 567106000833 AAA domain; Region: AAA_26; pfam13500 567106000834 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 567106000835 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 567106000836 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 567106000837 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 567106000838 5S rRNA interface [nucleotide binding]; other site 567106000839 CTC domain interface [polypeptide binding]; other site 567106000840 L16 interface [polypeptide binding]; other site 567106000841 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 567106000842 putative active site [active] 567106000843 catalytic residue [active] 567106000844 Predicted permeases [General function prediction only]; Region: COG0795 567106000845 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 567106000846 diaminopimelate decarboxylase; Region: lysA; TIGR01048 567106000847 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 567106000848 active site 567106000849 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 567106000850 substrate binding site [chemical binding]; other site 567106000851 catalytic residues [active] 567106000852 dimer interface [polypeptide binding]; other site 567106000853 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 567106000854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 567106000855 active site 567106000856 motif I; other site 567106000857 motif II; other site 567106000858 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 567106000859 chorismate mutase domain of proteobacterial P-protein, clade 2; Region: CM_P2; TIGR01807 567106000860 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 567106000861 Prephenate dehydratase; Region: PDT; pfam00800 567106000862 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 567106000863 putative L-Phe binding site [chemical binding]; other site 567106000864 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 567106000865 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 567106000866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106000867 homodimer interface [polypeptide binding]; other site 567106000868 catalytic residue [active] 567106000869 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 567106000870 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 567106000871 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 567106000872 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 567106000873 FliG C-terminal domain; Region: FliG_C; pfam01706 567106000874 flagellar assembly protein H; Validated; Region: fliH; PRK06669 567106000875 Flagellar assembly protein FliH; Region: FliH; pfam02108 567106000876 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 567106000877 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 567106000878 TPP-binding site; other site 567106000879 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 567106000880 PYR/PP interface [polypeptide binding]; other site 567106000881 dimer interface [polypeptide binding]; other site 567106000882 TPP binding site [chemical binding]; other site 567106000883 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 567106000884 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 567106000885 metal binding site 2 [ion binding]; metal-binding site 567106000886 putative DNA binding helix; other site 567106000887 metal binding site 1 [ion binding]; metal-binding site 567106000888 structural Zn2+ binding site [ion binding]; other site 567106000889 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 567106000890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106000891 S-adenosylmethionine binding site [chemical binding]; other site 567106000892 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 567106000893 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 567106000894 generic binding surface II; other site 567106000895 generic binding surface I; other site 567106000896 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 567106000897 homodimer interface [polypeptide binding]; other site 567106000898 substrate-cofactor binding pocket; other site 567106000899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106000900 catalytic residue [active] 567106000901 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 567106000902 homotrimer interaction site [polypeptide binding]; other site 567106000903 putative active site [active] 567106000904 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 567106000905 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 567106000906 dimer interface [polypeptide binding]; other site 567106000907 active site 567106000908 CoA binding pocket [chemical binding]; other site 567106000909 putative phosphate acyltransferase; Provisional; Region: PRK05331 567106000910 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 567106000911 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 567106000912 active site 567106000913 multimer interface [polypeptide binding]; other site 567106000914 Ferredoxin [Energy production and conversion]; Region: COG1146 567106000915 4Fe-4S binding domain; Region: Fer4; cl02805 567106000916 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 567106000917 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 567106000918 dimer interface [polypeptide binding]; other site 567106000919 decamer (pentamer of dimers) interface [polypeptide binding]; other site 567106000920 catalytic triad [active] 567106000921 peroxidatic and resolving cysteines [active] 567106000922 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 567106000923 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 567106000924 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 567106000925 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 567106000926 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 567106000927 ligand binding site [chemical binding]; other site 567106000928 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 567106000929 flagellar motor protein MotA; Validated; Region: PRK08456 567106000930 DNA polymerase I; Provisional; Region: PRK05755 567106000931 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 567106000932 active site 567106000933 metal binding site 1 [ion binding]; metal-binding site 567106000934 putative 5' ssDNA interaction site; other site 567106000935 metal binding site 3; metal-binding site 567106000936 metal binding site 2 [ion binding]; metal-binding site 567106000937 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 567106000938 putative DNA binding site [nucleotide binding]; other site 567106000939 putative metal binding site [ion binding]; other site 567106000940 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 567106000941 active site 567106000942 catalytic site [active] 567106000943 substrate binding site [chemical binding]; other site 567106000944 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 567106000945 active site 567106000946 DNA binding site [nucleotide binding] 567106000947 catalytic site [active] 567106000948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106000949 metabolite-proton symporter; Region: 2A0106; TIGR00883 567106000950 putative substrate translocation pore; other site 567106000951 nuc_hydro_CjNH. Nucleoside hydrolases similar to Campylobacter jejuni nucleoside hydrolase. This group contains eukaryotic and bacterial proteins similar to C. jejuni nucleoside hydrolase. Nucleoside hydrolases cleave the N-glycosidic bond in...; Region: nuc_hydro_CjNH; cd02654 567106000952 active site 567106000953 Predicted membrane protein [Function unknown]; Region: COG1238 567106000954 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 567106000955 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 567106000956 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 567106000957 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 567106000958 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 567106000959 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 567106000960 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 567106000961 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 567106000962 Glutamine amidotransferase class-I; Region: GATase; pfam00117 567106000963 glutamine binding [chemical binding]; other site 567106000964 catalytic triad [active] 567106000965 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 567106000966 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 567106000967 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 567106000968 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 567106000969 active site 567106000970 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 567106000971 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 567106000972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106000973 catalytic residue [active] 567106000974 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 567106000975 substrate binding site [chemical binding]; other site 567106000976 active site 567106000977 catalytic residues [active] 567106000978 heterodimer interface [polypeptide binding]; other site 567106000979 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 567106000980 flagellar motor switch protein; Validated; Region: PRK08433 567106000981 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 567106000982 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 567106000983 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 567106000984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 567106000985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 567106000986 active site 567106000987 phosphorylation site [posttranslational modification] 567106000988 intermolecular recognition site; other site 567106000989 dimerization interface [polypeptide binding]; other site 567106000990 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 567106000991 DNA binding site [nucleotide binding] 567106000992 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 567106000993 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 567106000994 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 567106000995 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 567106000996 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 567106000997 active site 567106000998 substrate binding site [chemical binding]; other site 567106000999 metal binding site [ion binding]; metal-binding site 567106001000 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 567106001001 lipoprotein signal peptidase; Provisional; Region: PRK14787 567106001002 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 567106001003 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 567106001004 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 567106001005 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 567106001006 Protein export membrane protein; Region: SecD_SecF; cl14618 567106001007 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 567106001008 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 567106001009 HlyD family secretion protein; Region: HlyD_3; pfam13437 567106001010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 567106001011 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 567106001012 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 567106001013 4Fe-4S binding domain; Region: Fer4_5; pfam12801 567106001014 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 567106001015 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 567106001016 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 567106001017 hypothetical protein; Provisional; Region: PRK04081 567106001018 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 567106001019 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 567106001020 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 567106001021 putative ligand binding site [chemical binding]; other site 567106001022 putative NAD binding site [chemical binding]; other site 567106001023 catalytic site [active] 567106001024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 567106001025 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 567106001026 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 567106001027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106001028 Walker A motif; other site 567106001029 ATP binding site [chemical binding]; other site 567106001030 Walker B motif; other site 567106001031 arginine finger; other site 567106001032 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 567106001033 TMAO/DMSO reductase; Reviewed; Region: PRK05363 567106001034 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 567106001035 Moco binding site; other site 567106001036 metal coordination site [ion binding]; other site 567106001037 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 567106001038 active site 567106001039 dimer interface [polypeptide binding]; other site 567106001040 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 567106001041 putative RNA binding site [nucleotide binding]; other site 567106001042 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 567106001043 homopentamer interface [polypeptide binding]; other site 567106001044 active site 567106001045 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 567106001046 EamA-like transporter family; Region: EamA; pfam00892 567106001047 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 567106001048 GTP-binding protein Der; Reviewed; Region: PRK00093 567106001049 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 567106001050 G1 box; other site 567106001051 GTP/Mg2+ binding site [chemical binding]; other site 567106001052 Switch I region; other site 567106001053 G2 box; other site 567106001054 Switch II region; other site 567106001055 G3 box; other site 567106001056 G4 box; other site 567106001057 G5 box; other site 567106001058 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 567106001059 GTP/Mg2+ binding site [chemical binding]; other site 567106001060 Switch I region; other site 567106001061 G2 box; other site 567106001062 G3 box; other site 567106001063 Switch II region; other site 567106001064 G4 box; other site 567106001065 G5 box; other site 567106001066 shikimate kinase; Reviewed; Region: aroK; PRK00131 567106001067 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 567106001068 ADP binding site [chemical binding]; other site 567106001069 magnesium binding site [ion binding]; other site 567106001070 putative shikimate binding site; other site 567106001071 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 567106001072 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 567106001073 active site 567106001074 HIGH motif; other site 567106001075 dimer interface [polypeptide binding]; other site 567106001076 KMSKS motif; other site 567106001077 seryl-tRNA synthetase; Provisional; Region: PRK05431 567106001078 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 567106001079 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 567106001080 dimer interface [polypeptide binding]; other site 567106001081 active site 567106001082 motif 1; other site 567106001083 motif 2; other site 567106001084 motif 3; other site 567106001085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 567106001086 binding surface 567106001087 TPR motif; other site 567106001088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 567106001089 TPR motif; other site 567106001090 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 567106001091 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 567106001092 domain interfaces; other site 567106001093 active site 567106001094 Predicted dehydrogenase [General function prediction only]; Region: COG0579 567106001095 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 567106001096 pantothenate kinase; Reviewed; Region: PRK13333 567106001097 PQQ-like domain; Region: PQQ_2; pfam13360 567106001098 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 567106001099 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 567106001100 Colicin V production protein; Region: Colicin_V; pfam02674 567106001101 ferric uptake regulator; Provisional; Region: fur; PRK09462 567106001102 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 567106001103 metal binding site 2 [ion binding]; metal-binding site 567106001104 putative DNA binding helix; other site 567106001105 metal binding site 1 [ion binding]; metal-binding site 567106001106 dimer interface [polypeptide binding]; other site 567106001107 structural Zn2+ binding site [ion binding]; other site 567106001108 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 567106001109 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 567106001110 dimer interface [polypeptide binding]; other site 567106001111 putative anticodon binding site; other site 567106001112 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 567106001113 motif 1; other site 567106001114 active site 567106001115 motif 2; other site 567106001116 motif 3; other site 567106001117 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 567106001118 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 567106001119 dimer interface [polypeptide binding]; other site 567106001120 active site 567106001121 glycine-pyridoxal phosphate binding site [chemical binding]; other site 567106001122 folate binding site [chemical binding]; other site 567106001123 Domain of unknown function (DUF1882); Region: DUF1882; pfam08966 567106001124 Sporulation related domain; Region: SPOR; pfam05036 567106001125 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 567106001126 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 567106001127 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 567106001128 shikimate binding site; other site 567106001129 NAD(P) binding site [chemical binding]; other site 567106001130 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 567106001131 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553 567106001132 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 567106001133 Iron-sulfur protein interface; other site 567106001134 proximal heme binding site [chemical binding]; other site 567106001135 distal heme binding site [chemical binding]; other site 567106001136 dimer interface [polypeptide binding]; other site 567106001137 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 567106001138 L-aspartate oxidase; Provisional; Region: PRK06175 567106001139 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 567106001140 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 567106001141 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 567106001142 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 567106001143 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 567106001144 Dynamin family; Region: Dynamin_N; pfam00350 567106001145 G1 box; other site 567106001146 GTP/Mg2+ binding site [chemical binding]; other site 567106001147 G2 box; other site 567106001148 Switch I region; other site 567106001149 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 567106001150 G3 box; other site 567106001151 Switch II region; other site 567106001152 GTP/Mg2+ binding site [chemical binding]; other site 567106001153 G4 box; other site 567106001154 G5 box; other site 567106001155 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 567106001156 Dynamin family; Region: Dynamin_N; pfam00350 567106001157 G1 box; other site 567106001158 GTP/Mg2+ binding site [chemical binding]; other site 567106001159 G2 box; other site 567106001160 Switch I region; other site 567106001161 G3 box; other site 567106001162 Switch II region; other site 567106001163 G4 box; other site 567106001164 G5 box; other site 567106001165 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 567106001166 Sel1-like repeats; Region: SEL1; smart00671 567106001167 Sel1-like repeats; Region: SEL1; smart00671 567106001168 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 567106001169 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 567106001170 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 567106001171 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 567106001172 SprA-related family; Region: SprA-related; pfam12118 567106001173 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 567106001174 HIT family signature motif; other site 567106001175 catalytic residue [active] 567106001176 Uncharacterized conserved protein [Function unknown]; Region: COG2353 567106001177 Transposase; Region: HTH_Tnp_1; cl17663 567106001178 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 567106001179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 567106001180 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 567106001181 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 567106001182 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 567106001183 ABC transporter; Region: ABC_tran_2; pfam12848 567106001184 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 567106001185 S-layer like family, C-terminal region; Region: S_layer_C; pfam05124 567106001186 Uncharacterized conserved protein [Function unknown]; Region: COG1739 567106001187 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 567106001188 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 567106001189 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 567106001190 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 567106001191 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 567106001192 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 567106001193 Mg++ binding site [ion binding]; other site 567106001194 putative catalytic motif [active] 567106001195 putative substrate binding site [chemical binding]; other site 567106001196 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 567106001197 phosphoglyceromutase; Provisional; Region: PRK05434 567106001198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 567106001199 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 567106001200 NAD(P) binding site [chemical binding]; other site 567106001201 active site 567106001202 Uncharacterized conserved protein [Function unknown]; Region: COG5015 567106001203 L-aspartate oxidase; Provisional; Region: PRK06175 567106001204 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 567106001205 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 567106001206 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 567106001207 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 567106001208 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 567106001209 Cysteine-rich domain; Region: CCG; pfam02754 567106001210 Cysteine-rich domain; Region: CCG; pfam02754 567106001211 Putative transcription activator [Transcription]; Region: TenA; COG0819 567106001212 acyl carrier protein; Provisional; Region: acpP; PRK00982 567106001213 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 567106001214 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 567106001215 dimer interface [polypeptide binding]; other site 567106001216 active site 567106001217 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 567106001218 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 567106001219 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 567106001220 dimer interface [polypeptide binding]; other site 567106001221 ADP-ribose binding site [chemical binding]; other site 567106001222 active site 567106001223 nudix motif; other site 567106001224 metal binding site [ion binding]; metal-binding site 567106001225 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 567106001226 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 567106001227 dimer interface [polypeptide binding]; other site 567106001228 putative CheW interface [polypeptide binding]; other site 567106001229 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 567106001230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 567106001231 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 567106001232 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 567106001233 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 567106001234 substrate binding site [chemical binding]; other site 567106001235 hexamer interface [polypeptide binding]; other site 567106001236 metal binding site [ion binding]; metal-binding site 567106001237 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 567106001238 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 567106001239 active site 567106001240 catalytic site [active] 567106001241 substrate binding site [chemical binding]; other site 567106001242 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 567106001243 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 567106001244 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 567106001245 putative acyl-acceptor binding pocket; other site 567106001246 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 567106001247 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 567106001248 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 567106001249 FeS/SAM binding site; other site 567106001250 TRAM domain; Region: TRAM; pfam01938 567106001251 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 567106001252 NusA N-terminal domain; Region: NusA_N; pfam08529 567106001253 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 567106001254 RNA binding site [nucleotide binding]; other site 567106001255 homodimer interface [polypeptide binding]; other site 567106001256 NusA-like KH domain; Region: KH_5; pfam13184 567106001257 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 567106001258 G-X-X-G motif; other site 567106001259 H+ Antiporter protein; Region: 2A0121; TIGR00900 567106001260 hypothetical protein; Provisional; Region: PRK08445 567106001261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 567106001262 FeS/SAM binding site; other site 567106001263 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 567106001264 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 567106001265 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 567106001266 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 567106001267 generic binding surface II; other site 567106001268 ssDNA binding site; other site 567106001269 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 567106001270 ATP binding site [chemical binding]; other site 567106001271 putative Mg++ binding site [ion binding]; other site 567106001272 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 567106001273 nucleotide binding region [chemical binding]; other site 567106001274 ATP-binding site [chemical binding]; other site 567106001275 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 567106001276 apolar tunnel; other site 567106001277 heme binding site [chemical binding]; other site 567106001278 dimerization interface [polypeptide binding]; other site 567106001279 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 567106001280 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 567106001281 ligand binding site [chemical binding]; other site 567106001282 flexible hinge region; other site 567106001283 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 567106001284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106001285 dimer interface [polypeptide binding]; other site 567106001286 conserved gate region; other site 567106001287 putative PBP binding loops; other site 567106001288 ABC-ATPase subunit interface; other site 567106001289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106001290 dimer interface [polypeptide binding]; other site 567106001291 conserved gate region; other site 567106001292 putative PBP binding loops; other site 567106001293 ABC-ATPase subunit interface; other site 567106001294 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 567106001295 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 567106001296 Walker A/P-loop; other site 567106001297 ATP binding site [chemical binding]; other site 567106001298 Q-loop/lid; other site 567106001299 ABC transporter signature motif; other site 567106001300 Walker B; other site 567106001301 D-loop; other site 567106001302 H-loop/switch region; other site 567106001303 elongation factor Tu; Reviewed; Region: PRK00049 567106001304 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 567106001305 G1 box; other site 567106001306 GEF interaction site [polypeptide binding]; other site 567106001307 GTP/Mg2+ binding site [chemical binding]; other site 567106001308 Switch I region; other site 567106001309 G2 box; other site 567106001310 G3 box; other site 567106001311 Switch II region; other site 567106001312 G4 box; other site 567106001313 G5 box; other site 567106001314 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 567106001315 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 567106001316 Antibiotic Binding Site [chemical binding]; other site 567106001317 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 567106001318 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 567106001319 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 567106001320 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 567106001321 putative homodimer interface [polypeptide binding]; other site 567106001322 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 567106001323 heterodimer interface [polypeptide binding]; other site 567106001324 homodimer interface [polypeptide binding]; other site 567106001325 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 567106001326 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 567106001327 23S rRNA interface [nucleotide binding]; other site 567106001328 L7/L12 interface [polypeptide binding]; other site 567106001329 putative thiostrepton binding site; other site 567106001330 L25 interface [polypeptide binding]; other site 567106001331 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 567106001332 mRNA/rRNA interface [nucleotide binding]; other site 567106001333 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 567106001334 23S rRNA interface [nucleotide binding]; other site 567106001335 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 567106001336 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 567106001337 L11 interface [polypeptide binding]; other site 567106001338 putative EF-Tu interaction site [polypeptide binding]; other site 567106001339 putative EF-G interaction site [polypeptide binding]; other site 567106001340 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 567106001341 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 567106001342 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 567106001343 RPB11 interaction site [polypeptide binding]; other site 567106001344 RPB12 interaction site [polypeptide binding]; other site 567106001345 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 567106001346 RPB3 interaction site [polypeptide binding]; other site 567106001347 RPB1 interaction site [polypeptide binding]; other site 567106001348 RPB11 interaction site [polypeptide binding]; other site 567106001349 RPB10 interaction site [polypeptide binding]; other site 567106001350 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 567106001351 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 567106001352 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 567106001353 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 567106001354 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 567106001355 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 567106001356 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 567106001357 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 567106001358 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 567106001359 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 567106001360 DNA binding site [nucleotide binding] 567106001361 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 567106001362 Transcriptional regulator [Transcription]; Region: IclR; COG1414 567106001363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 567106001364 putative DNA binding site [nucleotide binding]; other site 567106001365 putative Zn2+ binding site [ion binding]; other site 567106001366 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 567106001367 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 567106001368 inhibitor site; inhibition site 567106001369 active site 567106001370 dimer interface [polypeptide binding]; other site 567106001371 catalytic residue [active] 567106001372 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 567106001373 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 567106001374 potential frameshift: common BLAST hit: gi|218562139|ref|YP_002343918.1| MFS transport protein 567106001375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106001376 putative substrate translocation pore; other site 567106001377 short chain dehydrogenase; Provisional; Region: PRK08628 567106001378 classical (c) SDRs; Region: SDR_c; cd05233 567106001379 NAD(P) binding site [chemical binding]; other site 567106001380 active site 567106001381 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 567106001382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106001383 putative substrate translocation pore; other site 567106001384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106001385 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 567106001386 Amidohydrolase; Region: Amidohydro_2; pfam04909 567106001387 Domain of unknown function (DUF718); Region: DUF718; cl01281 567106001388 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 567106001389 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 567106001390 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 567106001391 NAD binding site [chemical binding]; other site 567106001392 catalytic residues [active] 567106001393 substrate binding site [chemical binding]; other site 567106001394 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 567106001395 S17 interaction site [polypeptide binding]; other site 567106001396 S8 interaction site; other site 567106001397 16S rRNA interaction site [nucleotide binding]; other site 567106001398 streptomycin interaction site [chemical binding]; other site 567106001399 23S rRNA interaction site [nucleotide binding]; other site 567106001400 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 567106001401 30S ribosomal protein S7; Validated; Region: PRK05302 567106001402 elongation factor G; Reviewed; Region: PRK00007 567106001403 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 567106001404 G1 box; other site 567106001405 putative GEF interaction site [polypeptide binding]; other site 567106001406 GTP/Mg2+ binding site [chemical binding]; other site 567106001407 Switch I region; other site 567106001408 G2 box; other site 567106001409 G3 box; other site 567106001410 Switch II region; other site 567106001411 G4 box; other site 567106001412 G5 box; other site 567106001413 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 567106001414 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 567106001415 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 567106001416 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 567106001417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106001418 S-adenosylmethionine binding site [chemical binding]; other site 567106001419 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 567106001420 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 567106001421 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 567106001422 active site 567106001423 substrate (anthranilate) binding pocket [chemical binding]; other site 567106001424 product (indole) binding pocket [chemical binding]; other site 567106001425 ribulose/triose binding site [chemical binding]; other site 567106001426 phosphate binding site [ion binding]; other site 567106001427 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 567106001428 nucleotide binding site/active site [active] 567106001429 HIT family signature motif; other site 567106001430 catalytic residue [active] 567106001431 Predicted ATPase [General function prediction only]; Region: COG2603 567106001432 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 567106001433 active site residue [active] 567106001434 ferrochelatase; Reviewed; Region: hemH; PRK00035 567106001435 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 567106001436 C-terminal domain interface [polypeptide binding]; other site 567106001437 active site 567106001438 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 567106001439 active site 567106001440 N-terminal domain interface [polypeptide binding]; other site 567106001441 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 567106001442 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 567106001443 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 567106001444 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 567106001445 inhibitor-cofactor binding pocket; inhibition site 567106001446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106001447 catalytic residue [active] 567106001448 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 567106001449 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 567106001450 motif 1; other site 567106001451 active site 567106001452 motif 2; other site 567106001453 motif 3; other site 567106001454 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 567106001455 DHHA1 domain; Region: DHHA1; pfam02272 567106001456 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 567106001457 Maf-like protein; Region: Maf; pfam02545 567106001458 active site 567106001459 dimer interface [polypeptide binding]; other site 567106001460 Transglycosylase; Region: Transgly; pfam00912 567106001461 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 567106001462 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 567106001463 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 567106001464 Clp amino terminal domain; Region: Clp_N; pfam02861 567106001465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106001466 Walker A motif; other site 567106001467 ATP binding site [chemical binding]; other site 567106001468 Walker B motif; other site 567106001469 arginine finger; other site 567106001470 Protein of unknown function (DUF972); Region: DUF972; pfam06156 567106001471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106001472 Walker A motif; other site 567106001473 ATP binding site [chemical binding]; other site 567106001474 Walker B motif; other site 567106001475 arginine finger; other site 567106001476 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 567106001477 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 567106001478 putative homodimer interface [polypeptide binding]; other site 567106001479 putative homotetramer interface [polypeptide binding]; other site 567106001480 putative metal binding site [ion binding]; other site 567106001481 putative homodimer-homodimer interface [polypeptide binding]; other site 567106001482 putative allosteric switch controlling residues; other site 567106001483 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 567106001484 C-terminal peptidase (prc); Region: prc; TIGR00225 567106001485 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 567106001486 protein binding site [polypeptide binding]; other site 567106001487 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 567106001488 Catalytic dyad [active] 567106001489 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 567106001490 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 567106001491 ATP binding site [chemical binding]; other site 567106001492 active site 567106001493 substrate binding site [chemical binding]; other site 567106001494 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 567106001495 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 567106001496 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 567106001497 putative active site [active] 567106001498 catalytic triad [active] 567106001499 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 567106001500 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 567106001501 putative acyl-acceptor binding pocket; other site 567106001502 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 567106001503 heat shock protein 90; Provisional; Region: PRK05218 567106001504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 567106001505 ATP binding site [chemical binding]; other site 567106001506 Mg2+ binding site [ion binding]; other site 567106001507 G-X-G motif; other site 567106001508 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 567106001509 active site residue [active] 567106001510 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 567106001511 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 567106001512 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 567106001513 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 567106001514 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 567106001515 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 567106001516 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK03907 567106001517 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 567106001518 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 567106001519 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 567106001520 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 567106001521 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 567106001522 YceG-like family; Region: YceG; pfam02618 567106001523 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 567106001524 dimerization interface [polypeptide binding]; other site 567106001525 Protein of unknown function; Region: DUF3971; pfam13116 567106001526 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 567106001527 AsmA-like C-terminal region; Region: AsmA_1; pfam13109 567106001528 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 567106001529 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 567106001530 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 567106001531 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 567106001532 NAD(P) binding site [chemical binding]; other site 567106001533 LDH/MDH dimer interface [polypeptide binding]; other site 567106001534 substrate binding site [chemical binding]; other site 567106001535 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 567106001536 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 567106001537 CoA-ligase; Region: Ligase_CoA; pfam00549 567106001538 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 567106001539 CoA binding domain; Region: CoA_binding; smart00881 567106001540 CoA-ligase; Region: Ligase_CoA; pfam00549 567106001541 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 567106001542 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 567106001543 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 567106001544 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 567106001545 dimer interface [polypeptide binding]; other site 567106001546 PYR/PP interface [polypeptide binding]; other site 567106001547 TPP binding site [chemical binding]; other site 567106001548 substrate binding site [chemical binding]; other site 567106001549 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 567106001550 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 567106001551 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 567106001552 TPP-binding site [chemical binding]; other site 567106001553 2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441 567106001554 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 567106001555 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 567106001556 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 567106001557 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 567106001558 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 567106001559 substrate binding pocket [chemical binding]; other site 567106001560 chain length determination region; other site 567106001561 substrate-Mg2+ binding site; other site 567106001562 catalytic residues [active] 567106001563 aspartate-rich region 1; other site 567106001564 active site lid residues [active] 567106001565 aspartate-rich region 2; other site 567106001566 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 567106001567 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 567106001568 tRNA; other site 567106001569 putative tRNA binding site [nucleotide binding]; other site 567106001570 putative NADP binding site [chemical binding]; other site 567106001571 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 567106001572 prolyl-tRNA synthetase; Provisional; Region: PRK09194 567106001573 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 567106001574 dimer interface [polypeptide binding]; other site 567106001575 motif 1; other site 567106001576 active site 567106001577 motif 2; other site 567106001578 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 567106001579 putative deacylase active site [active] 567106001580 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 567106001581 active site 567106001582 motif 3; other site 567106001583 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 567106001584 anticodon binding site; other site 567106001585 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 567106001586 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 567106001587 domain interfaces; other site 567106001588 active site 567106001589 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 567106001590 flagellar protein FlaG; Provisional; Region: PRK08452 567106001591 flagellar capping protein; Provisional; Region: PRK12765 567106001592 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 567106001593 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 567106001594 flagellar protein FliS; Validated; Region: fliS; PRK05685 567106001595 elongation factor P; Validated; Region: PRK00529 567106001596 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 567106001597 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 567106001598 RNA binding site [nucleotide binding]; other site 567106001599 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 567106001600 RNA binding site [nucleotide binding]; other site 567106001601 Predicted membrane protein [Function unknown]; Region: COG3819 567106001602 Predicted membrane protein [Function unknown]; Region: COG3817 567106001603 Protein of unknown function (DUF979); Region: DUF979; pfam06166 567106001604 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 567106001605 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 567106001606 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 567106001607 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 567106001608 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 567106001609 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 567106001610 active site 567106001611 Predicted membrane protein [Function unknown]; Region: COG1289 567106001612 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 567106001613 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 567106001614 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 567106001615 putative catalytic cysteine [active] 567106001616 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 567106001617 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 567106001618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 567106001619 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 567106001620 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 567106001621 Protein of unknown function (DUF2860); Region: DUF2860; pfam11059 567106001622 replicative DNA helicase; Provisional; Region: PRK08506 567106001623 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 567106001624 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 567106001625 Walker A motif; other site 567106001626 ATP binding site [chemical binding]; other site 567106001627 Walker B motif; other site 567106001628 DNA binding loops [nucleotide binding] 567106001629 Predicted transcriptional regulator [Transcription]; Region: COG2378 567106001630 HTH domain; Region: HTH_11; pfam08279 567106001631 WYL domain; Region: WYL; pfam13280 567106001632 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 567106001633 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 567106001634 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 567106001635 Uncharacterized conserved protein [Function unknown]; Region: COG1610 567106001636 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527 567106001637 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 567106001638 PYR/PP interface [polypeptide binding]; other site 567106001639 dimer interface [polypeptide binding]; other site 567106001640 TPP binding site [chemical binding]; other site 567106001641 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 567106001642 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 567106001643 TPP-binding site [chemical binding]; other site 567106001644 dimer interface [polypeptide binding]; other site 567106001645 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 567106001646 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 567106001647 putative valine binding site [chemical binding]; other site 567106001648 dimer interface [polypeptide binding]; other site 567106001649 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 567106001650 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 567106001651 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 567106001652 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 567106001653 trimer interface [polypeptide binding]; other site 567106001654 active site 567106001655 UDP-GlcNAc binding site [chemical binding]; other site 567106001656 lipid binding site [chemical binding]; lipid-binding site 567106001657 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 567106001658 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 567106001659 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 567106001660 sec-independent translocase; Provisional; Region: PRK04098 567106001661 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 567106001662 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 567106001663 putative active site [active] 567106001664 Ap4A binding site [chemical binding]; other site 567106001665 nudix motif; other site 567106001666 putative metal binding site [ion binding]; other site 567106001667 aspartate kinase; Reviewed; Region: PRK06635 567106001668 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 567106001669 putative nucleotide binding site [chemical binding]; other site 567106001670 putative catalytic residues [active] 567106001671 putative Mg ion binding site [ion binding]; other site 567106001672 putative aspartate binding site [chemical binding]; other site 567106001673 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 567106001674 putative allosteric regulatory site; other site 567106001675 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 567106001676 DNA replication regulator; Region: HobA; pfam12163 567106001677 DNA polymerase III subunit delta'; Validated; Region: PRK08485 567106001678 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 567106001679 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 567106001680 substrate binding pocket [chemical binding]; other site 567106001681 dimer interface [polypeptide binding]; other site 567106001682 inhibitor binding site; inhibition site 567106001683 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 567106001684 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 567106001685 nucleotide binding pocket [chemical binding]; other site 567106001686 K-X-D-G motif; other site 567106001687 catalytic site [active] 567106001688 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 567106001689 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 567106001690 Dimer interface [polypeptide binding]; other site 567106001691 BRCT sequence motif; other site 567106001692 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 567106001693 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 567106001694 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 567106001695 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 567106001696 active site 567106001697 nucleotide binding site [chemical binding]; other site 567106001698 HIGH motif; other site 567106001699 KMSKS motif; other site 567106001700 Riboflavin kinase; Region: Flavokinase; pfam01687 567106001701 Methyltransferase domain; Region: Methyltransf_31; pfam13847 567106001702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106001703 S-adenosylmethionine binding site [chemical binding]; other site 567106001704 Predicted membrane protein [Function unknown]; Region: COG2860 567106001705 UPF0126 domain; Region: UPF0126; pfam03458 567106001706 UPF0126 domain; Region: UPF0126; pfam03458 567106001707 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 567106001708 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 567106001709 active site 567106001710 substrate binding site [chemical binding]; other site 567106001711 Mg2+ binding site [ion binding]; other site 567106001712 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 567106001713 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 567106001714 minor groove reading motif; other site 567106001715 helix-hairpin-helix signature motif; other site 567106001716 substrate binding pocket [chemical binding]; other site 567106001717 active site 567106001718 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 567106001719 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 567106001720 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 567106001721 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 567106001722 active site 567106001723 intersubunit interface [polypeptide binding]; other site 567106001724 zinc binding site [ion binding]; other site 567106001725 Na+ binding site [ion binding]; other site 567106001726 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 567106001727 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 567106001728 hypothetical protein; Validated; Region: PRK09039 567106001729 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 567106001730 ligand binding site [chemical binding]; other site 567106001731 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 567106001732 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 567106001733 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 567106001734 catalytic residue [active] 567106001735 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 567106001736 Na2 binding site [ion binding]; other site 567106001737 putative substrate binding site 1 [chemical binding]; other site 567106001738 Na binding site 1 [ion binding]; other site 567106001739 putative substrate binding site 2 [chemical binding]; other site 567106001740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 567106001741 MOSC domain; Region: MOSC; pfam03473 567106001742 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 567106001743 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 567106001744 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 567106001745 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 567106001746 DsbD alpha interface [polypeptide binding]; other site 567106001747 catalytic residues [active] 567106001748 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 567106001749 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 567106001750 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 567106001751 metal binding site [ion binding]; metal-binding site 567106001752 dimer interface [polypeptide binding]; other site 567106001753 macrolide transporter subunit MacA; Provisional; Region: PRK11578 567106001754 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 567106001755 HlyD family secretion protein; Region: HlyD_3; pfam13437 567106001756 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 567106001757 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 567106001758 Walker A/P-loop; other site 567106001759 ATP binding site [chemical binding]; other site 567106001760 Q-loop/lid; other site 567106001761 ABC transporter signature motif; other site 567106001762 Walker B; other site 567106001763 D-loop; other site 567106001764 H-loop/switch region; other site 567106001765 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 567106001766 FtsX-like permease family; Region: FtsX; pfam02687 567106001767 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 567106001768 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 567106001769 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 567106001770 active site 567106001771 oxyanion hole [active] 567106001772 catalytic triad [active] 567106001773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2845 567106001774 active site 567106001775 catalytic triad [active] 567106001776 oxyanion hole [active] 567106001777 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 567106001778 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 567106001779 Ferritin-like domain; Region: Ferritin; pfam00210 567106001780 ferroxidase diiron center [ion binding]; other site 567106001781 PBP superfamily domain; Region: PBP_like_2; cl17296 567106001782 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 567106001783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106001784 dimer interface [polypeptide binding]; other site 567106001785 conserved gate region; other site 567106001786 putative PBP binding loops; other site 567106001787 ABC-ATPase subunit interface; other site 567106001788 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 567106001789 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 567106001790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106001791 dimer interface [polypeptide binding]; other site 567106001792 conserved gate region; other site 567106001793 putative PBP binding loops; other site 567106001794 ABC-ATPase subunit interface; other site 567106001795 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14269 567106001796 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 567106001797 Walker A/P-loop; other site 567106001798 ATP binding site [chemical binding]; other site 567106001799 Q-loop/lid; other site 567106001800 ABC transporter signature motif; other site 567106001801 Walker B; other site 567106001802 D-loop; other site 567106001803 H-loop/switch region; other site 567106001804 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 567106001805 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 567106001806 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 567106001807 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 567106001808 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 567106001809 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 567106001810 Acylphosphatase; Region: Acylphosphatase; pfam00708 567106001811 HypF finger; Region: zf-HYPF; pfam07503 567106001812 HypF finger; Region: zf-HYPF; pfam07503 567106001813 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 567106001814 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 567106001815 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 567106001816 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 567106001817 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 567106001818 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 567106001819 dimerization interface [polypeptide binding]; other site 567106001820 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 567106001821 ATP binding site [chemical binding]; other site 567106001822 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 567106001823 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 567106001824 Uncharacterized conserved protein [Function unknown]; Region: COG4748 567106001825 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 567106001826 DNA polymerase III subunit delta; Validated; Region: PRK08487 567106001827 Exoribonuclease R [Transcription]; Region: VacB; COG0557 567106001828 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 567106001829 RNB domain; Region: RNB; pfam00773 567106001830 ketol-acid reductoisomerase; Provisional; Region: PRK05479 567106001831 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 567106001832 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 567106001833 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 567106001834 NodB motif; other site 567106001835 putative active site [active] 567106001836 putative catalytic site [active] 567106001837 Zn binding site [ion binding]; other site 567106001838 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 567106001839 DNA protecting protein DprA; Region: dprA; TIGR00732 567106001840 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 567106001841 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 567106001842 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 567106001843 methionine sulfoxide reductase A; Provisional; Region: PRK14054 567106001844 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 567106001845 dimer interface [polypeptide binding]; other site 567106001846 substrate binding site [chemical binding]; other site 567106001847 metal binding sites [ion binding]; metal-binding site 567106001848 adenylate kinase; Reviewed; Region: adk; PRK00279 567106001849 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 567106001850 AMP-binding site [chemical binding]; other site 567106001851 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 567106001852 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 567106001853 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 567106001854 dimer interface [polypeptide binding]; other site 567106001855 anticodon binding site; other site 567106001856 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 567106001857 homodimer interface [polypeptide binding]; other site 567106001858 motif 1; other site 567106001859 active site 567106001860 motif 2; other site 567106001861 GAD domain; Region: GAD; pfam02938 567106001862 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 567106001863 active site 567106001864 motif 3; other site 567106001865 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: pnk; PRK14077 567106001866 ATP-NAD kinase; Region: NAD_kinase; pfam01513 567106001867 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 567106001868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 567106001869 Walker A/P-loop; other site 567106001870 ATP binding site [chemical binding]; other site 567106001871 Q-loop/lid; other site 567106001872 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 567106001873 ABC transporter signature motif; other site 567106001874 Walker B; other site 567106001875 D-loop; other site 567106001876 H-loop/switch region; other site 567106001877 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 567106001878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 567106001879 active site 567106001880 phosphorylation site [posttranslational modification] 567106001881 intermolecular recognition site; other site 567106001882 dimerization interface [polypeptide binding]; other site 567106001883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 567106001884 active site 567106001885 phosphorylation site [posttranslational modification] 567106001886 intermolecular recognition site; other site 567106001887 dimerization interface [polypeptide binding]; other site 567106001888 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 567106001889 metal binding site [ion binding]; metal-binding site 567106001890 active site 567106001891 I-site; other site 567106001892 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 567106001893 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 567106001894 active site 567106001895 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 567106001896 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 567106001897 N-acetyl-D-glucosamine binding site [chemical binding]; other site 567106001898 catalytic residue [active] 567106001899 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 567106001900 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 567106001901 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 567106001902 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 567106001903 Sporulation related domain; Region: SPOR; pfam05036 567106001904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 567106001905 active site 567106001906 motif I; other site 567106001907 motif II; other site 567106001908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 567106001909 OstA-like protein; Region: OstA; pfam03968 567106001910 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 567106001911 G1 box; other site 567106001912 GTP/Mg2+ binding site [chemical binding]; other site 567106001913 Switch I region; other site 567106001914 G2 box; other site 567106001915 G3 box; other site 567106001916 Switch II region; other site 567106001917 G4 box; other site 567106001918 G5 box; other site 567106001919 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 567106001920 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 567106001921 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 567106001922 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 567106001923 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 567106001924 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 567106001925 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 567106001926 active site 567106001927 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 567106001928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106001929 putative substrate translocation pore; other site 567106001930 POT family; Region: PTR2; cl17359 567106001931 POT family; Region: PTR2; cl17359 567106001932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106001933 putative substrate translocation pore; other site 567106001934 GTPase Era; Reviewed; Region: era; PRK00089 567106001935 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 567106001936 G1 box; other site 567106001937 GTP/Mg2+ binding site [chemical binding]; other site 567106001938 Switch I region; other site 567106001939 G2 box; other site 567106001940 Switch II region; other site 567106001941 G3 box; other site 567106001942 G4 box; other site 567106001943 G5 box; other site 567106001944 KH domain; Region: KH_2; pfam07650 567106001945 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 567106001946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106001947 Walker A motif; other site 567106001948 ATP binding site [chemical binding]; other site 567106001949 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 567106001950 Walker B motif; other site 567106001951 arginine finger; other site 567106001952 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 567106001953 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 567106001954 active site 567106001955 HslU subunit interaction site [polypeptide binding]; other site 567106001956 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 567106001957 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 567106001958 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 567106001959 argininosuccinate synthase; Provisional; Region: PRK13820 567106001960 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 567106001961 ANP binding site [chemical binding]; other site 567106001962 Substrate Binding Site II [chemical binding]; other site 567106001963 Substrate Binding Site I [chemical binding]; other site 567106001964 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis]; Region: COG1188 567106001965 RNA binding surface [nucleotide binding]; other site 567106001966 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 567106001967 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 567106001968 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 567106001969 Walker A/P-loop; other site 567106001970 ATP binding site [chemical binding]; other site 567106001971 Q-loop/lid; other site 567106001972 ABC transporter signature motif; other site 567106001973 Walker B; other site 567106001974 D-loop; other site 567106001975 H-loop/switch region; other site 567106001976 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 567106001977 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 567106001978 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 567106001979 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 567106001980 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 567106001981 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 567106001982 potential frameshift: common BLAST hit: gi|157414949|ref|YP_001482205.1| potassium-transporting ATPase subunit B 567106001983 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 567106001984 potential frameshift: common BLAST hit: gi|157414949|ref|YP_001482205.1| potassium-transporting ATPase subunit B 567106001985 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 567106001986 Soluble P-type ATPase [General function prediction only]; Region: COG4087 567106001987 K+-transporting ATPase, c chain; Region: KdpC; cl00944 567106001988 potential frameshift: common BLAST hit: gi|218562318|ref|YP_002344097.1| truncated KdpD protein 567106001989 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 567106001990 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 567106001991 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 567106001992 excinuclease ABC subunit B; Provisional; Region: PRK05298 567106001993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 567106001994 ATP binding site [chemical binding]; other site 567106001995 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 567106001996 nucleotide binding region [chemical binding]; other site 567106001997 ATP-binding site [chemical binding]; other site 567106001998 Ultra-violet resistance protein B; Region: UvrB; pfam12344 567106001999 primosome assembly protein PriA; Validated; Region: PRK05580 567106002000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 567106002001 ATP binding site [chemical binding]; other site 567106002002 putative Mg++ binding site [ion binding]; other site 567106002003 helicase superfamily c-terminal domain; Region: HELICc; smart00490 567106002004 ATP-binding site [chemical binding]; other site 567106002005 Protein of unknown function (DUF2972); Region: DUF2972; pfam11186 567106002006 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 567106002007 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 567106002008 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 567106002009 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 567106002010 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 567106002011 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 567106002012 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 567106002013 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 567106002014 propionate/acetate kinase; Provisional; Region: PRK12379 567106002015 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 567106002016 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 567106002017 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 567106002018 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 567106002019 MraW methylase family; Region: Methyltransf_5; cl17771 567106002020 SurA N-terminal domain; Region: SurA_N_3; cl07813 567106002021 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 567106002022 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 567106002023 cell division protein FtsA; Region: ftsA; TIGR01174 567106002024 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 567106002025 nucleotide binding site [chemical binding]; other site 567106002026 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 567106002027 Cell division protein FtsA; Region: FtsA; pfam14450 567106002028 cell division protein FtsZ; Validated; Region: PRK09330 567106002029 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 567106002030 nucleotide binding site [chemical binding]; other site 567106002031 SulA interaction site; other site 567106002032 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 567106002033 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 567106002034 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 567106002035 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 567106002036 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 567106002037 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 567106002038 glutamine synthetase, type I; Region: GlnA; TIGR00653 567106002039 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 567106002040 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 567106002041 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 567106002042 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 567106002043 Peptidase family U32; Region: Peptidase_U32; pfam01136 567106002044 AIR carboxylase; Region: AIRC; smart01001 567106002045 Protein of unknown function (DUF3972); Region: DUF3972; pfam13118 567106002046 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 567106002047 dimer interface [polypeptide binding]; other site 567106002048 motif 1; other site 567106002049 active site 567106002050 motif 2; other site 567106002051 motif 3; other site 567106002052 Uncharacterized conserved protein [Function unknown]; Region: COG0327 567106002053 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 567106002054 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 567106002055 Putative zinc ribbon domain; Region: DUF164; pfam02591 567106002056 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 567106002057 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 567106002058 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 567106002059 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 567106002060 active site 567106002061 signal recognition particle protein; Provisional; Region: PRK10867 567106002062 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 567106002063 P loop; other site 567106002064 GTP binding site [chemical binding]; other site 567106002065 Signal peptide binding domain; Region: SRP_SPB; pfam02978 567106002066 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 567106002067 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 567106002068 KH domain; Region: KH_4; pfam13083 567106002069 G-X-X-G motif; other site 567106002070 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 567106002071 RimM N-terminal domain; Region: RimM; pfam01782 567106002072 PRC-barrel domain; Region: PRC; pfam05239 567106002073 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 567106002074 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 567106002075 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 567106002076 active site 567106002077 homotetramer interface [polypeptide binding]; other site 567106002078 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 567106002079 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 567106002080 ArsC family; Region: ArsC; pfam03960 567106002081 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 567106002082 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 567106002083 active site 567106002084 PHP Thumb interface [polypeptide binding]; other site 567106002085 metal binding site [ion binding]; metal-binding site 567106002086 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 567106002087 generic binding surface I; other site 567106002088 generic binding surface II; other site 567106002089 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 567106002090 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 567106002091 catalytic residue [active] 567106002092 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 567106002093 flagellin; Provisional; Region: PRK12804 567106002094 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 567106002095 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 567106002096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 567106002097 Peptidase family M48; Region: Peptidase_M48; pfam01435 567106002098 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 567106002099 MPT binding site; other site 567106002100 trimer interface [polypeptide binding]; other site 567106002101 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 567106002102 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 567106002103 oligomer interface [polypeptide binding]; other site 567106002104 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 567106002105 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 567106002106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 567106002107 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 567106002108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 567106002109 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 567106002110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106002111 dimer interface [polypeptide binding]; other site 567106002112 conserved gate region; other site 567106002113 putative PBP binding loops; other site 567106002114 ABC-ATPase subunit interface; other site 567106002115 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 567106002116 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 567106002117 Walker A/P-loop; other site 567106002118 ATP binding site [chemical binding]; other site 567106002119 Q-loop/lid; other site 567106002120 ABC transporter signature motif; other site 567106002121 Walker B; other site 567106002122 D-loop; other site 567106002123 H-loop/switch region; other site 567106002124 TOBE domain; Region: TOBE_2; pfam08402 567106002125 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 567106002126 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 567106002127 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 567106002128 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 567106002129 substrate binding pocket [chemical binding]; other site 567106002130 membrane-bound complex binding site; other site 567106002131 hinge residues; other site 567106002132 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 567106002133 haemagglutination activity domain; Region: Haemagg_act; smart00912 567106002134 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 567106002135 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 567106002136 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 567106002137 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 567106002138 N-terminal plug; other site 567106002139 ligand-binding site [chemical binding]; other site 567106002140 heat-inducible transcription repressor; Provisional; Region: PRK03911 567106002141 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 567106002142 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 567106002143 dimer interface [polypeptide binding]; other site 567106002144 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 567106002145 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 567106002146 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 567106002147 nucleotide binding site [chemical binding]; other site 567106002148 NEF interaction site [polypeptide binding]; other site 567106002149 SBD interface [polypeptide binding]; other site 567106002150 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 567106002151 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 567106002152 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 567106002153 aspartate aminotransferase; Provisional; Region: PRK05764 567106002154 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 567106002155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106002156 homodimer interface [polypeptide binding]; other site 567106002157 catalytic residue [active] 567106002158 serine O-acetyltransferase; Region: cysE; TIGR01172 567106002159 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 567106002160 trimer interface [polypeptide binding]; other site 567106002161 active site 567106002162 substrate binding site [chemical binding]; other site 567106002163 CoA binding site [chemical binding]; other site 567106002164 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 567106002165 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 567106002166 dimer interface [polypeptide binding]; other site 567106002167 active site 567106002168 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 567106002169 catalytic residues [active] 567106002170 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 567106002171 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 567106002172 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 567106002173 dimer interface [polypeptide binding]; other site 567106002174 motif 1; other site 567106002175 active site 567106002176 motif 2; other site 567106002177 motif 3; other site 567106002178 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 567106002179 anticodon binding site; other site 567106002180 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 567106002181 thymidylate kinase; Validated; Region: tmk; PRK00698 567106002182 TMP-binding site; other site 567106002183 ATP-binding site [chemical binding]; other site 567106002184 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 567106002185 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 567106002186 active site 567106002187 (T/H)XGH motif; other site 567106002188 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 567106002189 Flavoprotein; Region: Flavoprotein; pfam02441 567106002190 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515 567106002191 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 567106002192 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 567106002193 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 567106002194 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 567106002195 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 567106002196 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 567106002197 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 567106002198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106002199 ABC-ATPase subunit interface; other site 567106002200 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 567106002201 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 567106002202 Walker A/P-loop; other site 567106002203 ATP binding site [chemical binding]; other site 567106002204 Q-loop/lid; other site 567106002205 ABC transporter signature motif; other site 567106002206 Walker B; other site 567106002207 D-loop; other site 567106002208 H-loop/switch region; other site 567106002209 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 567106002210 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 567106002211 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 567106002212 active site 567106002213 HIGH motif; other site 567106002214 nucleotide binding site [chemical binding]; other site 567106002215 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 567106002216 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 567106002217 active site 567106002218 KMSKS motif; other site 567106002219 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 567106002220 tRNA binding surface [nucleotide binding]; other site 567106002221 anticodon binding site; other site 567106002222 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 567106002223 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 567106002224 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 567106002225 Part of AAA domain; Region: AAA_19; pfam13245 567106002226 Family description; Region: UvrD_C_2; pfam13538 567106002227 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 567106002228 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 567106002229 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 567106002230 dimer interface [polypeptide binding]; other site 567106002231 catalytic triad [active] 567106002232 peroxidatic and resolving cysteines [active] 567106002233 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 567106002234 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 567106002235 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 567106002236 molybdopterin cofactor binding site; other site 567106002237 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 567106002238 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 567106002239 molybdopterin cofactor binding site; other site 567106002240 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 567106002241 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 567106002242 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 567106002243 4Fe-4S binding domain; Region: Fer4_5; pfam12801 567106002244 4Fe-4S binding domain; Region: Fer4; cl02805 567106002245 Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043 567106002246 FOG: WD40 repeat [General function prediction only]; Region: COG2319 567106002247 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 567106002248 Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062 567106002249 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 567106002250 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 567106002251 active site 567106002252 NTP binding site [chemical binding]; other site 567106002253 metal binding triad [ion binding]; metal-binding site 567106002254 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 567106002255 Formyltetrahydrofolate hydrolase [Nucleotide transport and metabolism]; Region: PurU; COG0788 567106002256 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 567106002257 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 567106002258 putative active site [active] 567106002259 putative substrate binding site [chemical binding]; other site 567106002260 putative cosubstrate binding site; other site 567106002261 catalytic site [active] 567106002262 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 567106002263 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 567106002264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 567106002265 catalytic residue [active] 567106002266 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 567106002267 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 567106002268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 567106002269 dimer interface [polypeptide binding]; other site 567106002270 phosphorylation site [posttranslational modification] 567106002271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 567106002272 ATP binding site [chemical binding]; other site 567106002273 Mg2+ binding site [ion binding]; other site 567106002274 G-X-G motif; other site 567106002275 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 567106002276 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 567106002277 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 567106002278 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 567106002279 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 567106002280 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 567106002281 ATP-grasp domain; Region: ATP-grasp_4; cl17255 567106002282 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14601 567106002283 RuvA N terminal domain; Region: RuvA_N; pfam01330 567106002284 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 567106002285 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 567106002286 Protein of unknown function (DUF342); Region: DUF342; pfam03961 567106002287 integral membrane protein MviN; Region: mviN; TIGR01695 567106002288 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 567106002289 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 567106002290 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 567106002291 active site 567106002292 HIGH motif; other site 567106002293 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 567106002294 KMSKS motif; other site 567106002295 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 567106002296 tRNA binding surface [nucleotide binding]; other site 567106002297 anticodon binding site; other site 567106002298 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 567106002299 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 567106002300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 567106002301 Walker A/P-loop; other site 567106002302 ATP binding site [chemical binding]; other site 567106002303 Q-loop/lid; other site 567106002304 ABC transporter signature motif; other site 567106002305 Walker B; other site 567106002306 D-loop; other site 567106002307 H-loop/switch region; other site 567106002308 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 567106002309 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 567106002310 quinone interaction residues [chemical binding]; other site 567106002311 active site 567106002312 catalytic residues [active] 567106002313 FMN binding site [chemical binding]; other site 567106002314 substrate binding site [chemical binding]; other site 567106002315 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 567106002316 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 567106002317 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 567106002318 dihydrodipicolinate synthase; Region: dapA; TIGR00674 567106002319 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 567106002320 dimer interface [polypeptide binding]; other site 567106002321 active site 567106002322 catalytic residue [active] 567106002323 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 567106002324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 567106002325 NAD(P) binding site [chemical binding]; other site 567106002326 active site 567106002327 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 567106002328 NAD synthetase; Provisional; Region: PRK13980 567106002329 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 567106002330 homodimer interface [polypeptide binding]; other site 567106002331 NAD binding pocket [chemical binding]; other site 567106002332 ATP binding pocket [chemical binding]; other site 567106002333 Mg binding site [ion binding]; other site 567106002334 active-site loop [active] 567106002335 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 567106002336 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 567106002337 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 567106002338 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 567106002339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106002340 catalytic residue [active] 567106002341 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 567106002342 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 567106002343 Ligand binding site; other site 567106002344 oligomer interface; other site 567106002345 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 567106002346 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 567106002347 substrate binding pocket [chemical binding]; other site 567106002348 membrane-bound complex binding site; other site 567106002349 hinge residues; other site 567106002350 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 567106002351 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 567106002352 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 567106002353 Substrate binding site; other site 567106002354 Mg++ binding site; other site 567106002355 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 567106002356 active site 567106002357 substrate binding site [chemical binding]; other site 567106002358 CoA binding site [chemical binding]; other site 567106002359 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 567106002360 Flavoprotein; Region: Flavoprotein; pfam02441 567106002361 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 567106002362 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 567106002363 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 567106002364 catalytic residue [active] 567106002365 putative FPP diphosphate binding site; other site 567106002366 putative FPP binding hydrophobic cleft; other site 567106002367 dimer interface [polypeptide binding]; other site 567106002368 putative IPP diphosphate binding site; other site 567106002369 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 567106002370 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 567106002371 Predicted permeases [General function prediction only]; Region: COG0795 567106002372 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 567106002373 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 567106002374 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 567106002375 dimerization interface 3.5A [polypeptide binding]; other site 567106002376 active site 567106002377 threonine dehydratase; Provisional; Region: PRK08526 567106002378 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 567106002379 tetramer interface [polypeptide binding]; other site 567106002380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106002381 catalytic residue [active] 567106002382 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 567106002383 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 567106002384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 567106002385 tRNA (Uracil-5-)-methyltransferase; Region: tRNA_U5-meth_tr; pfam05958 567106002386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106002387 S-adenosylmethionine binding site [chemical binding]; other site 567106002388 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 567106002389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 567106002390 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 567106002391 NAD(P) binding site [chemical binding]; other site 567106002392 active site 567106002393 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 567106002394 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 567106002395 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 567106002396 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 567106002397 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 567106002398 substrate binding site [chemical binding]; other site 567106002399 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 567106002400 substrate binding site [chemical binding]; other site 567106002401 ligand binding site [chemical binding]; other site 567106002402 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 567106002403 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 567106002404 DNA binding site [nucleotide binding] 567106002405 active site 567106002406 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 567106002407 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 567106002408 active site 567106002409 HIGH motif; other site 567106002410 KMSKS motif; other site 567106002411 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 567106002412 tRNA binding surface [nucleotide binding]; other site 567106002413 anticodon binding site; other site 567106002414 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 567106002415 putative tRNA-binding site [nucleotide binding]; other site 567106002416 dimer interface [polypeptide binding]; other site 567106002417 Fructose-1,6-bisphosphatase [Carbohydrate transport and metabolism]; Region: Fbp; COG0158 567106002418 active site 567106002419 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 567106002420 Walker A motif; other site 567106002421 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 567106002422 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 567106002423 N-acetyl-D-glucosamine binding site [chemical binding]; other site 567106002424 catalytic residue [active] 567106002425 YGGT family; Region: YGGT; pfam02325 567106002426 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 567106002427 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 567106002428 active site 567106002429 HIGH motif; other site 567106002430 nucleotide binding site [chemical binding]; other site 567106002431 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 567106002432 active site 567106002433 KMSKS motif; other site 567106002434 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 567106002435 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 567106002436 putative active site [active] 567106002437 putative metal binding site [ion binding]; other site 567106002438 phosphatidylserine decarboxylase; Provisional; Region: PRK03934 567106002439 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 567106002440 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 567106002441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106002442 putative substrate translocation pore; other site 567106002443 Major Facilitator Superfamily; Region: MFS_1; pfam07690 567106002444 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 567106002445 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 567106002446 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 567106002447 inhibitor-cofactor binding pocket; inhibition site 567106002448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106002449 catalytic residue [active] 567106002450 ubiquitin-activating enzyme E1; Region: Ube1; TIGR01408 567106002451 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14166 567106002452 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 567106002453 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 567106002454 homodimer interface [polypeptide binding]; other site 567106002455 NADP binding site [chemical binding]; other site 567106002456 substrate binding site [chemical binding]; other site 567106002457 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 567106002458 Catalytic site [active] 567106002459 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 567106002460 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 567106002461 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 567106002462 dimer interface [polypeptide binding]; other site 567106002463 putative functional site; other site 567106002464 putative MPT binding site; other site 567106002465 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 567106002466 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 567106002467 hinge; other site 567106002468 active site 567106002469 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 567106002470 Glutamine amidotransferase class-I; Region: GATase; pfam00117 567106002471 glutamine binding [chemical binding]; other site 567106002472 catalytic triad [active] 567106002473 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 567106002474 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 567106002475 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 567106002476 substrate-cofactor binding pocket; other site 567106002477 homodimer interface [polypeptide binding]; other site 567106002478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106002479 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 567106002480 catalytic residue [active] 567106002481 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 567106002482 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 567106002483 active site 567106002484 DNA binding site [nucleotide binding] 567106002485 Int/Topo IB signature motif; other site 567106002486 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 567106002487 putative disulfide oxidoreductase; Provisional; Region: PRK04307 567106002488 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 567106002489 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 567106002490 catalytic residues [active] 567106002491 hinge region; other site 567106002492 alpha helical domain; other site 567106002493 Cytochrome c [Energy production and conversion]; Region: COG3258 567106002494 Cytochrome c [Energy production and conversion]; Region: COG3258 567106002495 Cytochrome c; Region: Cytochrom_C; pfam00034 567106002496 DHH family; Region: DHH; pfam01368 567106002497 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 567106002498 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 567106002499 FHIPEP family; Region: FHIPEP; pfam00771 567106002500 Rrf2 family protein; Region: rrf2_super; TIGR00738 567106002501 Transcriptional regulator; Region: Rrf2; pfam02082 567106002502 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 567106002503 16S/18S rRNA binding site [nucleotide binding]; other site 567106002504 S13e-L30e interaction site [polypeptide binding]; other site 567106002505 25S rRNA binding site [nucleotide binding]; other site 567106002506 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 567106002507 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 567106002508 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 567106002509 lagellar hook-associated protein FlgL; Provisional; Region: PRK14692 567106002510 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 567106002511 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 567106002512 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 567106002513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 567106002514 Walker A/P-loop; other site 567106002515 ATP binding site [chemical binding]; other site 567106002516 Q-loop/lid; other site 567106002517 ABC transporter signature motif; other site 567106002518 Walker B; other site 567106002519 D-loop; other site 567106002520 H-loop/switch region; other site 567106002521 ABC transporter; Region: ABC_tran_2; pfam12848 567106002522 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 567106002523 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 567106002524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 567106002525 ATP binding site [chemical binding]; other site 567106002526 Mg2+ binding site [ion binding]; other site 567106002527 G-X-G motif; other site 567106002528 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 567106002529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 567106002530 active site 567106002531 phosphorylation site [posttranslational modification] 567106002532 intermolecular recognition site; other site 567106002533 dimerization interface [polypeptide binding]; other site 567106002534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 567106002535 DNA binding site [nucleotide binding] 567106002536 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 567106002537 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 567106002538 ligand binding site [chemical binding]; other site 567106002539 NAD binding site [chemical binding]; other site 567106002540 dimerization interface [polypeptide binding]; other site 567106002541 catalytic site [active] 567106002542 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 567106002543 putative L-serine binding site [chemical binding]; other site 567106002544 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 567106002545 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 567106002546 RNA binding site [nucleotide binding]; other site 567106002547 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 567106002548 RNA binding site [nucleotide binding]; other site 567106002549 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 567106002550 RNA binding site [nucleotide binding]; other site 567106002551 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 567106002552 RNA binding site [nucleotide binding]; other site 567106002553 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 567106002554 RNA binding site [nucleotide binding]; other site 567106002555 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 567106002556 RNA binding site [nucleotide binding]; other site 567106002557 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 567106002558 LytB protein; Region: LYTB; pfam02401 567106002559 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 567106002560 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 567106002561 hinge; other site 567106002562 active site 567106002563 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 567106002564 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 567106002565 putative tRNA-binding site [nucleotide binding]; other site 567106002566 B3/4 domain; Region: B3_4; pfam03483 567106002567 tRNA synthetase B5 domain; Region: B5; smart00874 567106002568 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 567106002569 dimer interface [polypeptide binding]; other site 567106002570 motif 1; other site 567106002571 motif 3; other site 567106002572 motif 2; other site 567106002573 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 567106002574 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 567106002575 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 567106002576 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 567106002577 dimer interface [polypeptide binding]; other site 567106002578 motif 1; other site 567106002579 active site 567106002580 motif 2; other site 567106002581 motif 3; other site 567106002582 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 567106002583 nucleotide binding site/active site [active] 567106002584 HIT family signature motif; other site 567106002585 catalytic residue [active] 567106002586 DJ-1 family protein; Region: not_thiJ; TIGR01383 567106002587 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 567106002588 conserved cys residue [active] 567106002589 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 567106002590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106002591 dimer interface [polypeptide binding]; other site 567106002592 conserved gate region; other site 567106002593 putative PBP binding loops; other site 567106002594 ABC-ATPase subunit interface; other site 567106002595 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 567106002596 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 567106002597 Walker A/P-loop; other site 567106002598 ATP binding site [chemical binding]; other site 567106002599 Q-loop/lid; other site 567106002600 ABC transporter signature motif; other site 567106002601 Walker B; other site 567106002602 D-loop; other site 567106002603 H-loop/switch region; other site 567106002604 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 567106002605 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 567106002606 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 567106002607 alanine racemase; Reviewed; Region: alr; PRK00053 567106002608 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 567106002609 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 567106002610 catalytic residue [active] 567106002611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 567106002612 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 567106002613 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 567106002614 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 567106002615 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 567106002616 Cu(I) binding site [ion binding]; other site 567106002617 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 567106002618 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 567106002619 dimer interface [polypeptide binding]; other site 567106002620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106002621 catalytic residue [active] 567106002622 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 567106002623 IHF dimer interface [polypeptide binding]; other site 567106002624 IHF - DNA interface [nucleotide binding]; other site 567106002625 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 567106002626 Uncharacterized small protein [Function unknown]; Region: COG2879 567106002627 carbon starvation protein A; Provisional; Region: PRK15015 567106002628 Carbon starvation protein CstA; Region: CstA; pfam02554 567106002629 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 567106002630 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 567106002631 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 567106002632 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 567106002633 active site 567106002634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106002635 dimer interface [polypeptide binding]; other site 567106002636 conserved gate region; other site 567106002637 putative PBP binding loops; other site 567106002638 ABC-ATPase subunit interface; other site 567106002639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106002640 dimer interface [polypeptide binding]; other site 567106002641 conserved gate region; other site 567106002642 putative PBP binding loops; other site 567106002643 ABC-ATPase subunit interface; other site 567106002644 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 567106002645 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 567106002646 substrate binding pocket [chemical binding]; other site 567106002647 membrane-bound complex binding site; other site 567106002648 hinge residues; other site 567106002649 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 567106002650 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 567106002651 Walker A/P-loop; other site 567106002652 ATP binding site [chemical binding]; other site 567106002653 Q-loop/lid; other site 567106002654 ABC transporter signature motif; other site 567106002655 Walker B; other site 567106002656 D-loop; other site 567106002657 H-loop/switch region; other site 567106002658 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 567106002659 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 567106002660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106002661 S-adenosylmethionine binding site [chemical binding]; other site 567106002662 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 567106002663 CheB methylesterase; Region: CheB_methylest; pfam01339 567106002664 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 567106002665 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 567106002666 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 567106002667 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 567106002668 active site 567106002669 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 567106002670 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 567106002671 multifunctional aminopeptidase A; Provisional; Region: PRK00913 567106002672 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 567106002673 interface (dimer of trimers) [polypeptide binding]; other site 567106002674 Substrate-binding/catalytic site; other site 567106002675 Zn-binding sites [ion binding]; other site 567106002676 GTP-binding protein YchF; Reviewed; Region: PRK09601 567106002677 YchF GTPase; Region: YchF; cd01900 567106002678 G1 box; other site 567106002679 GTP/Mg2+ binding site [chemical binding]; other site 567106002680 Switch I region; other site 567106002681 G2 box; other site 567106002682 Switch II region; other site 567106002683 G3 box; other site 567106002684 G4 box; other site 567106002685 G5 box; other site 567106002686 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 567106002687 argininosuccinate lyase; Provisional; Region: PRK00855 567106002688 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 567106002689 active sites [active] 567106002690 tetramer interface [polypeptide binding]; other site 567106002691 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 567106002692 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 567106002693 active site 567106002694 substrate-binding site [chemical binding]; other site 567106002695 metal-binding site [ion binding] 567106002696 ATP binding site [chemical binding]; other site 567106002697 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 567106002698 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 567106002699 active site 567106002700 catalytic residues [active] 567106002701 metal binding site [ion binding]; metal-binding site 567106002702 homodimer binding site [polypeptide binding]; other site 567106002703 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 567106002704 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 567106002705 carboxyltransferase (CT) interaction site; other site 567106002706 biotinylation site [posttranslational modification]; other site 567106002707 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 567106002708 putative substrate binding site 2 [chemical binding]; other site 567106002709 putative substrate binding site 1 [chemical binding]; other site 567106002710 Na binding site 1 [ion binding]; other site 567106002711 Na2 binding site [ion binding]; other site 567106002712 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 567106002713 Na2 binding site [ion binding]; other site 567106002714 putative substrate binding site 1 [chemical binding]; other site 567106002715 Na binding site 1 [ion binding]; other site 567106002716 putative substrate binding site 2 [chemical binding]; other site 567106002717 F0F1 ATP synthase subunit C; Validated; Region: PRK08482 567106002718 Predicted permeases [General function prediction only]; Region: COG0679 567106002719 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 567106002720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106002721 putative substrate translocation pore; other site 567106002722 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 567106002723 putative acyl-acceptor binding pocket; other site 567106002724 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 567106002725 acyl-activating enzyme (AAE) consensus motif; other site 567106002726 AMP binding site [chemical binding]; other site 567106002727 active site 567106002728 CoA binding site [chemical binding]; other site 567106002729 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 567106002730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106002731 dimer interface [polypeptide binding]; other site 567106002732 conserved gate region; other site 567106002733 putative PBP binding loops; other site 567106002734 ABC-ATPase subunit interface; other site 567106002735 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 567106002736 FtsX-like permease family; Region: FtsX; pfam02687 567106002737 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 567106002738 DEAD/DEAH box helicase; Region: DEAD; pfam00270 567106002739 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 567106002740 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 567106002741 nucleotide binding region [chemical binding]; other site 567106002742 ATP-binding site [chemical binding]; other site 567106002743 SEC-C motif; Region: SEC-C; pfam02810 567106002744 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 567106002745 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 567106002746 PIF1-like helicase; Region: PIF1; pfam05970 567106002747 Helicase; Region: Herpes_Helicase; pfam02689 567106002748 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 567106002749 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 567106002750 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 567106002751 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 567106002752 NlpC/P60 family; Region: NLPC_P60; cl17555 567106002753 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 567106002754 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 567106002755 putative active site; other site 567106002756 catalytic triad [active] 567106002757 putative dimer interface [polypeptide binding]; other site 567106002758 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 567106002759 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 567106002760 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957 567106002761 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 567106002762 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 567106002763 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 567106002764 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 567106002765 dimer interface [polypeptide binding]; other site 567106002766 putative CheW interface [polypeptide binding]; other site 567106002767 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 567106002768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 567106002769 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 567106002770 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 567106002771 purine monophosphate binding site [chemical binding]; other site 567106002772 dimer interface [polypeptide binding]; other site 567106002773 putative catalytic residues [active] 567106002774 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 567106002775 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 567106002776 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 567106002777 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 567106002778 putative metal binding site [ion binding]; other site 567106002779 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 567106002780 HSP70 interaction site [polypeptide binding]; other site 567106002781 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 567106002782 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 567106002783 dimerization interface [polypeptide binding]; other site 567106002784 ATP binding site [chemical binding]; other site 567106002785 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 567106002786 dimerization interface [polypeptide binding]; other site 567106002787 ATP binding site [chemical binding]; other site 567106002788 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 567106002789 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 567106002790 trmE is a tRNA modification GTPase; Region: trmE; cd04164 567106002791 G1 box; other site 567106002792 GTP/Mg2+ binding site [chemical binding]; other site 567106002793 Switch I region; other site 567106002794 G2 box; other site 567106002795 Switch II region; other site 567106002796 G3 box; other site 567106002797 G4 box; other site 567106002798 G5 box; other site 567106002799 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 567106002800 membrane protein insertase; Provisional; Region: PRK01318 567106002801 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 567106002802 Uncharacterized conserved protein [Function unknown]; Region: COG0759 567106002803 RNase P protein component [Translation, ribosomal structure and biogenesis]; Region: RnpA; COG0594 567106002804 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 567106002805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 567106002806 Coenzyme A binding pocket [chemical binding]; other site 567106002807 Uracil-DNA glycosylase [DNA replication, recombination, and repair]; Region: COG1573 567106002808 ligand binding site [chemical binding]; other site 567106002809 active site 567106002810 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 567106002811 active site 567106002812 potential frameshift: common BLAST hit: gi|121612600|ref|YP_001000204.1| putative periplasmic protein 567106002813 potential frameshift: common BLAST hit: gi|121612600|ref|YP_001000204.1| putative periplasmic protein 567106002814 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 567106002815 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 567106002816 Methyltransferase domain; Region: Methyltransf_23; pfam13489 567106002817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106002818 S-adenosylmethionine binding site [chemical binding]; other site 567106002819 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 567106002820 active site 1 [active] 567106002821 active site 2 [active] 567106002822 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 567106002823 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 567106002824 Catalytic site; other site 567106002825 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 567106002826 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 567106002827 metal binding site [ion binding]; metal-binding site 567106002828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106002829 metabolite-proton symporter; Region: 2A0106; TIGR00883 567106002830 putative substrate translocation pore; other site 567106002831 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 567106002832 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 567106002833 substrate binding pocket [chemical binding]; other site 567106002834 membrane-bound complex binding site; other site 567106002835 hinge residues; other site 567106002836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3022 567106002837 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 567106002838 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 567106002839 metal binding site [ion binding]; metal-binding site 567106002840 putative dimer interface [polypeptide binding]; other site 567106002841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106002842 putative substrate translocation pore; other site 567106002843 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 567106002844 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 567106002845 Cysteine-rich domain; Region: CCG; pfam02754 567106002846 Cysteine-rich domain; Region: CCG; pfam02754 567106002847 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 567106002848 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 567106002849 FeS/SAM binding site; other site 567106002850 HemN C-terminal domain; Region: HemN_C; pfam06969 567106002851 Protein of unknown function (DUF2603); Region: DUF2603; pfam10788 567106002852 ornithine carbamoyltransferase; Provisional; Region: PRK00779 567106002853 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 567106002854 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 567106002855 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 567106002856 dimer interface [polypeptide binding]; other site 567106002857 active site 567106002858 Schiff base residues; other site 567106002859 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 567106002860 dimerization interface [polypeptide binding]; other site 567106002861 active site 567106002862 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 567106002863 16S rRNA (guanine(527)-N(7))-methyltransferase GidB; Region: gidB; TIGR00138 567106002864 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 567106002865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 567106002866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 567106002867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 567106002868 dimerization interface [polypeptide binding]; other site 567106002869 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 567106002870 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 567106002871 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 567106002872 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 567106002873 DNA binding residues [nucleotide binding] 567106002874 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 567106002875 catalytic core [active] 567106002876 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 567106002877 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 567106002878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106002879 Walker A motif; other site 567106002880 ATP binding site [chemical binding]; other site 567106002881 Walker B motif; other site 567106002882 arginine finger; other site 567106002883 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 567106002884 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 567106002885 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 567106002886 Mechanosensitive ion channel; Region: MS_channel; pfam00924 567106002887 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 567106002888 active site 567106002889 dimer interface [polypeptide binding]; other site 567106002890 metal binding site [ion binding]; metal-binding site 567106002891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 567106002892 TrkA-C domain; Region: TrkA_C; pfam02080 567106002893 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 567106002894 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 567106002895 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 567106002896 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 567106002897 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 567106002898 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 567106002899 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 567106002900 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 567106002901 Walker A/P-loop; other site 567106002902 ATP binding site [chemical binding]; other site 567106002903 Q-loop/lid; other site 567106002904 ABC transporter signature motif; other site 567106002905 Walker B; other site 567106002906 D-loop; other site 567106002907 H-loop/switch region; other site 567106002908 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 567106002909 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 567106002910 Walker A/P-loop; other site 567106002911 ATP binding site [chemical binding]; other site 567106002912 Q-loop/lid; other site 567106002913 ABC transporter signature motif; other site 567106002914 Walker B; other site 567106002915 D-loop; other site 567106002916 H-loop/switch region; other site 567106002917 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 567106002918 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 567106002919 TM-ABC transporter signature motif; other site 567106002920 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 567106002921 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 567106002922 TM-ABC transporter signature motif; other site 567106002923 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 567106002924 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 567106002925 putative ligand binding site [chemical binding]; other site 567106002926 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 567106002927 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 567106002928 putative ligand binding site [chemical binding]; other site 567106002929 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 567106002930 Cytochrome c; Region: Cytochrom_C; cl11414 567106002931 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 567106002932 Predicted membrane protein [Function unknown]; Region: COG2862 567106002933 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 567106002934 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 567106002935 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 567106002936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 567106002937 active site 567106002938 phosphorylation site [posttranslational modification] 567106002939 intermolecular recognition site; other site 567106002940 dimerization interface [polypeptide binding]; other site 567106002941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106002942 Walker A motif; other site 567106002943 ATP binding site [chemical binding]; other site 567106002944 Walker B motif; other site 567106002945 arginine finger; other site 567106002946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3018 567106002947 DNA gyrase subunit A; Validated; Region: PRK05560 567106002948 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 567106002949 CAP-like domain; other site 567106002950 active site 567106002951 primary dimer interface [polypeptide binding]; other site 567106002952 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 567106002953 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 567106002954 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 567106002955 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 567106002956 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 567106002957 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 567106002958 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 567106002959 active site 567106002960 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 567106002961 GTP-binding protein LepA; Provisional; Region: PRK05433 567106002962 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 567106002963 G1 box; other site 567106002964 putative GEF interaction site [polypeptide binding]; other site 567106002965 GTP/Mg2+ binding site [chemical binding]; other site 567106002966 Switch I region; other site 567106002967 G2 box; other site 567106002968 G3 box; other site 567106002969 Switch II region; other site 567106002970 G4 box; other site 567106002971 G5 box; other site 567106002972 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 567106002973 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 567106002974 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 567106002975 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 567106002976 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 567106002977 HlyD family secretion protein; Region: HlyD_3; pfam13437 567106002978 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 567106002979 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 567106002980 HSP70 interaction site [polypeptide binding]; other site 567106002981 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 567106002982 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 567106002983 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 567106002984 acetyl-CoA carboxylase subunit A; Validated; Region: PRK08463 567106002985 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 567106002986 ATP-grasp domain; Region: ATP-grasp_4; cl17255 567106002987 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 567106002988 cell division protein FtsW; Region: ftsW; TIGR02614 567106002989 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 567106002990 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 567106002991 active site 567106002992 homodimer interface [polypeptide binding]; other site 567106002993 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 567106002994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106002995 putative substrate translocation pore; other site 567106002996 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 567106002997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 567106002998 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 567106002999 thiamine phosphate binding site [chemical binding]; other site 567106003000 active site 567106003001 pyrophosphate binding site [ion binding]; other site 567106003002 thiazole biosynthesis protein ThiH; Region: thiH; TIGR02351 567106003003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 567106003004 FeS/SAM binding site; other site 567106003005 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 567106003006 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 567106003007 ThiS interaction site; other site 567106003008 putative active site [active] 567106003009 tetramer interface [polypeptide binding]; other site 567106003010 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 567106003011 thiamine biosynthesis protein ThiF, family 2; Region: thiF_fam2; TIGR02354 567106003012 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 567106003013 putative ATP binding site [chemical binding]; other site 567106003014 putative substrate interface [chemical binding]; other site 567106003015 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 567106003016 thiS-thiF/thiG interaction site; other site 567106003017 succinyl-diaminopimelate desuccinylase, proteobacterial clade; Region: dapE_proteo; TIGR01246 567106003018 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 567106003019 metal binding site [ion binding]; metal-binding site 567106003020 dimer interface [polypeptide binding]; other site 567106003021 LysE type translocator; Region: LysE; pfam01810 567106003022 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 567106003023 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 567106003024 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 567106003025 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 567106003026 Methyltransferase domain; Region: Methyltransf_26; pfam13659 567106003027 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 567106003028 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 567106003029 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 567106003030 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 567106003031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 567106003032 Walker A/P-loop; other site 567106003033 ATP binding site [chemical binding]; other site 567106003034 Q-loop/lid; other site 567106003035 ABC transporter signature motif; other site 567106003036 Walker B; other site 567106003037 D-loop; other site 567106003038 H-loop/switch region; other site 567106003039 Smr domain; Region: Smr; pfam01713 567106003040 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 567106003041 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 567106003042 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 567106003043 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 567106003044 Sulfatase; Region: Sulfatase; cl17466 567106003045 Predicted amidohydrolase [General function prediction only]; Region: COG0388 567106003046 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 567106003047 active site 567106003048 catalytic triad [active] 567106003049 dimer interface [polypeptide binding]; other site 567106003050 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 567106003051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 567106003052 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 567106003053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 567106003054 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 567106003055 active site 567106003056 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 567106003057 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 567106003058 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 567106003059 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 567106003060 active site 567106003061 HIGH motif; other site 567106003062 nucleotide binding site [chemical binding]; other site 567106003063 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 567106003064 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 567106003065 active site 567106003066 KMSKS motif; other site 567106003067 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 567106003068 tRNA binding surface [nucleotide binding]; other site 567106003069 anticodon binding site; other site 567106003070 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 567106003071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 567106003072 Coenzyme A binding pocket [chemical binding]; other site 567106003073 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 567106003074 dimer interface [polypeptide binding]; other site 567106003075 FMN binding site [chemical binding]; other site 567106003076 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 567106003077 dimer interface [polypeptide binding]; other site 567106003078 FMN binding site [chemical binding]; other site 567106003079 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 567106003080 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 567106003081 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 567106003082 active site 567106003083 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 567106003084 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 567106003085 putative substrate binding region [chemical binding]; other site 567106003086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 567106003087 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 567106003088 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 567106003089 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 567106003090 dimer interface [polypeptide binding]; other site 567106003091 ssDNA binding site [nucleotide binding]; other site 567106003092 tetramer (dimer of dimers) interface [polypeptide binding]; other site 567106003093 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 567106003094 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 567106003095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106003096 Walker A motif; other site 567106003097 ATP binding site [chemical binding]; other site 567106003098 Walker B motif; other site 567106003099 arginine finger; other site 567106003100 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 567106003101 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 567106003102 flagellar assembly protein FliW; Provisional; Region: PRK13282 567106003103 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 567106003104 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 567106003105 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 567106003106 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 567106003107 active site 567106003108 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 567106003109 thiamine phosphate binding site [chemical binding]; other site 567106003110 active site 567106003111 pyrophosphate binding site [ion binding]; other site 567106003112 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 567106003113 substrate binding site [chemical binding]; other site 567106003114 dimer interface [polypeptide binding]; other site 567106003115 ATP binding site [chemical binding]; other site 567106003116 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 567106003117 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 567106003118 minor groove reading motif; other site 567106003119 helix-hairpin-helix signature motif; other site 567106003120 active site 567106003121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106003122 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 567106003123 Walker A motif; other site 567106003124 ATP binding site [chemical binding]; other site 567106003125 Walker B motif; other site 567106003126 arginine finger; other site 567106003127 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 567106003128 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 567106003129 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 567106003130 ATP binding site [chemical binding]; other site 567106003131 putative Mg++ binding site [ion binding]; other site 567106003132 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 567106003133 nucleotide binding region [chemical binding]; other site 567106003134 ATP-binding site [chemical binding]; other site 567106003135 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 567106003136 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 567106003137 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 567106003138 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 567106003139 Peptidase family M23; Region: Peptidase_M23; pfam01551 567106003140 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 567106003141 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 567106003142 Lipopolysaccharide-assembly; Region: LptE; pfam04390 567106003143 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 567106003144 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 567106003145 HIGH motif; other site 567106003146 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 567106003147 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 567106003148 active site 567106003149 KMSKS motif; other site 567106003150 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 567106003151 tRNA binding surface [nucleotide binding]; other site 567106003152 anticodon binding site; other site 567106003153 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 567106003154 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 567106003155 Protein export membrane protein; Region: SecD_SecF; pfam02355 567106003156 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 567106003157 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 567106003158 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 567106003159 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 567106003160 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 567106003161 active site 567106003162 catalytic triad [active] 567106003163 dimer interface [polypeptide binding]; other site 567106003164 S-adenosylmethionine synthetase; Validated; Region: PRK05250 567106003165 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 567106003166 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 567106003167 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 567106003168 Na+/serine symporter [Amino acid transport and metabolism]; Region: SstT; COG3633 567106003169 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 567106003170 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 567106003171 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 567106003172 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 567106003173 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 567106003174 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 567106003175 active site 567106003176 Zn binding site [ion binding]; other site 567106003177 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 567106003178 Part of AAA domain; Region: AAA_19; pfam13245 567106003179 Family description; Region: UvrD_C_2; pfam13538 567106003180 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04099 567106003181 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 567106003182 active site 567106003183 RNA-binding global regulator CsrA [Signal transduction mechanisms]; Region: CsrA; COG1551 567106003184 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 567106003185 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 567106003186 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 567106003187 SmpB-tmRNA interface; other site 567106003188 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 567106003189 catalytic residues [active] 567106003190 Uncharacterized conserved protein [Function unknown]; Region: COG2127 567106003191 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 567106003192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106003193 Walker A motif; other site 567106003194 ATP binding site [chemical binding]; other site 567106003195 Walker B motif; other site 567106003196 arginine finger; other site 567106003197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106003198 Walker A motif; other site 567106003199 ATP binding site [chemical binding]; other site 567106003200 Walker B motif; other site 567106003201 arginine finger; other site 567106003202 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 567106003203 Leu/Phe-tRNA-protein transferase [Posttranslational modification, protein turnover, chaperones]; Region: Aat; COG2360 567106003204 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 567106003205 methionine sulfoxide reductase B; Provisional; Region: PRK05508 567106003206 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 567106003207 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 567106003208 dinuclear metal binding motif [ion binding]; other site 567106003209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 567106003210 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 567106003211 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 567106003212 Phosphatidylserine decarboxylase [Lipid metabolism]; Region: Psd; COG0688 567106003213 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 567106003214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106003215 Walker A motif; other site 567106003216 ATP binding site [chemical binding]; other site 567106003217 Walker B motif; other site 567106003218 arginine finger; other site 567106003219 Peptidase family M41; Region: Peptidase_M41; pfam01434 567106003220 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 567106003221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106003222 S-adenosylmethionine binding site [chemical binding]; other site 567106003223 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 567106003224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 567106003225 active site 567106003226 phosphorylation site [posttranslational modification] 567106003227 intermolecular recognition site; other site 567106003228 dimerization interface [polypeptide binding]; other site 567106003229 Cache domain; Region: Cache_1; pfam02743 567106003230 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 567106003231 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 567106003232 NAD(P) binding site [chemical binding]; other site 567106003233 homodimer interface [polypeptide binding]; other site 567106003234 substrate binding site [chemical binding]; other site 567106003235 active site 567106003236 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 567106003237 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 567106003238 inhibitor-cofactor binding pocket; inhibition site 567106003239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106003240 catalytic residue [active] 567106003241 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 567106003242 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 567106003243 putative trimer interface [polypeptide binding]; other site 567106003244 putative CoA binding site [chemical binding]; other site 567106003245 Bacterial sugar transferase; Region: Bac_transf; pfam02397 567106003246 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 567106003247 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 567106003248 putative ADP-binding pocket [chemical binding]; other site 567106003249 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 567106003250 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 567106003251 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 567106003252 putative ADP-binding pocket [chemical binding]; other site 567106003253 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 567106003254 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 567106003255 active site 567106003256 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 567106003257 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 567106003258 putative ADP-binding pocket [chemical binding]; other site 567106003259 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 567106003260 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 567106003261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 567106003262 Walker A/P-loop; other site 567106003263 ATP binding site [chemical binding]; other site 567106003264 Q-loop/lid; other site 567106003265 ABC transporter signature motif; other site 567106003266 Walker B; other site 567106003267 D-loop; other site 567106003268 H-loop/switch region; other site 567106003269 UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179 567106003270 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 567106003271 NAD binding site [chemical binding]; other site 567106003272 homodimer interface [polypeptide binding]; other site 567106003273 active site 567106003274 substrate binding site [chemical binding]; other site 567106003275 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 567106003276 active site 567106003277 catalytic site [active] 567106003278 substrate binding site [chemical binding]; other site 567106003279 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 567106003280 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 567106003281 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 567106003282 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 567106003283 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 567106003284 putative active site [active] 567106003285 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 567106003286 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 567106003287 putative acyl-acceptor binding pocket; other site 567106003288 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 567106003289 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 567106003290 putative metal binding site; other site 567106003291 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 567106003292 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 567106003293 Substrate binding site; other site 567106003294 metal-binding site 567106003295 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 567106003296 active site 567106003297 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 567106003298 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 567106003299 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 567106003300 active site 567106003301 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 567106003302 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 567106003303 active site 567106003304 Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002 567106003305 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 567106003306 NeuB family; Region: NeuB; pfam03102 567106003307 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 567106003308 NeuB binding interface [polypeptide binding]; other site 567106003309 putative substrate binding site [chemical binding]; other site 567106003310 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 567106003311 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 567106003312 active site 567106003313 homodimer interface [polypeptide binding]; other site 567106003314 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA); Region: CgtA; pfam06306 567106003315 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 567106003316 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 567106003317 ligand binding site; other site 567106003318 tetramer interface; other site 567106003319 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 567106003320 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 567106003321 active site 567106003322 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 567106003323 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 567106003324 putative active site [active] 567106003325 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 567106003326 dimer interface [polypeptide binding]; other site 567106003327 active site 567106003328 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 567106003329 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 567106003330 putative ribose interaction site [chemical binding]; other site 567106003331 putative ADP binding site [chemical binding]; other site 567106003332 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 567106003333 active site 567106003334 nucleotide binding site [chemical binding]; other site 567106003335 HIGH motif; other site 567106003336 KMSKS motif; other site 567106003337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 567106003338 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 567106003339 NAD(P) binding site [chemical binding]; other site 567106003340 active site 567106003341 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 567106003342 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 567106003343 active site 567106003344 motif I; other site 567106003345 motif II; other site 567106003346 Cytochrome c553 [Energy production and conversion]; Region: COG2863 567106003347 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 567106003348 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 567106003349 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 567106003350 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 567106003351 metal-binding site [ion binding] 567106003352 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 567106003353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 567106003354 motif II; other site 567106003355 transcription termination factor Rho; Provisional; Region: rho; PRK09376 567106003356 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 567106003357 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 567106003358 RNA binding site [nucleotide binding]; other site 567106003359 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 567106003360 multimer interface [polypeptide binding]; other site 567106003361 Walker A motif; other site 567106003362 ATP binding site [chemical binding]; other site 567106003363 Walker B motif; other site 567106003364 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08451 567106003365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106003366 Walker A motif; other site 567106003367 ATP binding site [chemical binding]; other site 567106003368 DNA polymerase III subunit delta'; Validated; Region: PRK08485 567106003369 Walker B motif; other site 567106003370 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 567106003371 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 567106003372 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 567106003373 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 567106003374 metal-binding site [ion binding] 567106003375 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 567106003376 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 567106003377 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 567106003378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 567106003379 Uncharacterized conserved protein [Function unknown]; Region: COG3610 567106003380 Uncharacterized conserved protein [Function unknown]; Region: COG2966 567106003381 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 567106003382 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 567106003383 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 567106003384 NAD binding site [chemical binding]; other site 567106003385 dimer interface [polypeptide binding]; other site 567106003386 tetramer (dimer of dimers) interface [polypeptide binding]; other site 567106003387 substrate binding site [chemical binding]; other site 567106003388 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 567106003389 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 567106003390 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 567106003391 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 567106003392 active site 567106003393 hypothetical protein; Provisional; Region: PRK12378 567106003394 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 567106003395 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 567106003396 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 567106003397 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 567106003398 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 567106003399 active site 567106003400 HIGH motif; other site 567106003401 KMSK motif region; other site 567106003402 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 567106003403 tRNA binding surface [nucleotide binding]; other site 567106003404 anticodon binding site; other site 567106003405 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 567106003406 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 567106003407 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 567106003408 catalytic site [active] 567106003409 G-X2-G-X-G-K; other site 567106003410 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 567106003411 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 567106003412 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 567106003413 Walker A/P-loop; other site 567106003414 ATP binding site [chemical binding]; other site 567106003415 Q-loop/lid; other site 567106003416 ABC transporter signature motif; other site 567106003417 Walker B; other site 567106003418 D-loop; other site 567106003419 H-loop/switch region; other site 567106003420 elongation factor Ts; Provisional; Region: tsf; PRK09377 567106003421 UBA/TS-N domain; Region: UBA; pfam00627 567106003422 Elongation factor TS; Region: EF_TS; pfam00889 567106003423 Elongation factor TS; Region: EF_TS; pfam00889 567106003424 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 567106003425 rRNA interaction site [nucleotide binding]; other site 567106003426 S8 interaction site; other site 567106003427 putative laminin-1 binding site; other site 567106003428 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 567106003429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106003430 S-adenosylmethionine binding site [chemical binding]; other site 567106003431 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 567106003432 Cytochrome c; Region: Cytochrom_C; pfam00034 567106003433 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 567106003434 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 567106003435 intrachain domain interface; other site 567106003436 interchain domain interface [polypeptide binding]; other site 567106003437 heme bH binding site [chemical binding]; other site 567106003438 Qi binding site; other site 567106003439 heme bL binding site [chemical binding]; other site 567106003440 Qo binding site; other site 567106003441 interchain domain interface [polypeptide binding]; other site 567106003442 intrachain domain interface; other site 567106003443 Qi binding site; other site 567106003444 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 567106003445 Qo binding site; other site 567106003446 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 567106003447 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 567106003448 [2Fe-2S] cluster binding site [ion binding]; other site 567106003449 arsenical pump membrane protein; Provisional; Region: PRK15445 567106003450 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 567106003451 transmembrane helices; other site 567106003452 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 567106003453 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 567106003454 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 567106003455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 567106003456 PAS domain; Region: PAS_9; pfam13426 567106003457 putative active site [active] 567106003458 heme pocket [chemical binding]; other site 567106003459 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 567106003460 dimer interface [polypeptide binding]; other site 567106003461 putative CheW interface [polypeptide binding]; other site 567106003462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 567106003463 PAS domain; Region: PAS_9; pfam13426 567106003464 putative active site [active] 567106003465 heme pocket [chemical binding]; other site 567106003466 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 567106003467 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 567106003468 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 567106003469 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 567106003470 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 567106003471 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 567106003472 dihydroorotase; Provisional; Region: PRK08417 567106003473 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 567106003474 active site 567106003475 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 567106003476 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 567106003477 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 567106003478 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 567106003479 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 567106003480 GatB domain; Region: GatB_Yqey; smart00845 567106003481 S-ribosylhomocysteinase; Provisional; Region: PRK02260 567106003482 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 567106003483 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 567106003484 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 567106003485 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 567106003486 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 567106003487 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 567106003488 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 567106003489 THF binding site; other site 567106003490 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 567106003491 substrate binding site [chemical binding]; other site 567106003492 THF binding site; other site 567106003493 zinc-binding site [ion binding]; other site 567106003494 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 567106003495 FAD binding site [chemical binding]; other site 567106003496 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 567106003497 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 567106003498 DNA repair protein RadA; Provisional; Region: PRK11823 567106003499 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 567106003500 Walker A motif; other site 567106003501 ATP binding site [chemical binding]; other site 567106003502 Walker B motif; other site 567106003503 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 567106003504 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 567106003505 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 567106003506 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 567106003507 P loop; other site 567106003508 GTP binding site [chemical binding]; other site 567106003509 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 567106003510 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 567106003511 catalytic residues [active] 567106003512 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 567106003513 phosphodiesterase; Provisional; Region: PRK12704 567106003514 KH domain; Region: KH_1; pfam00013 567106003515 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 567106003516 Zn2+ binding site [ion binding]; other site 567106003517 Mg2+ binding site [ion binding]; other site 567106003518 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 567106003519 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 567106003520 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 567106003521 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 567106003522 FAD binding domain; Region: FAD_binding_4; pfam01565 567106003523 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 567106003524 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 567106003525 Peptidase family M23; Region: Peptidase_M23; pfam01551 567106003526 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 567106003527 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 567106003528 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 567106003529 Lumazine binding domain; Region: Lum_binding; pfam00677 567106003530 Lumazine binding domain; Region: Lum_binding; pfam00677 567106003531 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 567106003532 oligomerisation interface [polypeptide binding]; other site 567106003533 mobile loop; other site 567106003534 roof hairpin; other site 567106003535 chaperonin GroL; Region: GroEL; TIGR02348 567106003536 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 567106003537 ring oligomerisation interface [polypeptide binding]; other site 567106003538 ATP/Mg binding site [chemical binding]; other site 567106003539 stacking interactions; other site 567106003540 hinge regions; other site 567106003541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 567106003542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 567106003543 dimer interface [polypeptide binding]; other site 567106003544 phosphorylation site [posttranslational modification] 567106003545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 567106003546 ATP binding site [chemical binding]; other site 567106003547 Mg2+ binding site [ion binding]; other site 567106003548 G-X-G motif; other site 567106003549 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 567106003550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 567106003551 active site 567106003552 phosphorylation site [posttranslational modification] 567106003553 intermolecular recognition site; other site 567106003554 dimerization interface [polypeptide binding]; other site 567106003555 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 567106003556 DNA binding site [nucleotide binding] 567106003557 Hemerythrin; Region: Hemerythrin; cd12107 567106003558 Fe binding site [ion binding]; other site 567106003559 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 567106003560 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 567106003561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 567106003562 dimer interface [polypeptide binding]; other site 567106003563 phosphorylation site [posttranslational modification] 567106003564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 567106003565 ATP binding site [chemical binding]; other site 567106003566 Mg2+ binding site [ion binding]; other site 567106003567 G-X-G motif; other site 567106003568 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 567106003569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 567106003570 active site 567106003571 phosphorylation site [posttranslational modification] 567106003572 intermolecular recognition site; other site 567106003573 dimerization interface [polypeptide binding]; other site 567106003574 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 567106003575 DNA binding site [nucleotide binding] 567106003576 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 567106003577 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 567106003578 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 567106003579 protein binding site [polypeptide binding]; other site 567106003580 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 567106003581 protein binding site [polypeptide binding]; other site 567106003582 chaperone protein DnaJ; Provisional; Region: PRK14299 567106003583 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 567106003584 HSP70 interaction site [polypeptide binding]; other site 567106003585 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 567106003586 substrate binding site [polypeptide binding]; other site 567106003587 dimer interface [polypeptide binding]; other site 567106003588 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 567106003589 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 567106003590 DNA binding residues [nucleotide binding] 567106003591 putative dimer interface [polypeptide binding]; other site 567106003592 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 567106003593 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 567106003594 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 567106003595 TrkA-N domain; Region: TrkA_N; pfam02254 567106003596 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 567106003597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 567106003598 motif II; other site 567106003599 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 567106003600 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 567106003601 Peptidase family M23; Region: Peptidase_M23; pfam01551 567106003602 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 567106003603 exopolyphosphatase; Region: exo_poly_only; TIGR03706 567106003604 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 567106003605 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 567106003606 active site 567106003607 hydrophilic channel; other site 567106003608 dimerization interface [polypeptide binding]; other site 567106003609 catalytic residues [active] 567106003610 active site lid [active] 567106003611 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946 567106003612 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 567106003613 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 567106003614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106003615 putative substrate translocation pore; other site 567106003616 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 567106003617 substrate binding site [chemical binding]; other site 567106003618 active site 567106003619 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 567106003620 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 567106003621 FeS/SAM binding site; other site 567106003622 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 567106003623 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 567106003624 GIY-YIG motif/motif A; other site 567106003625 active site 567106003626 catalytic site [active] 567106003627 putative DNA binding site [nucleotide binding]; other site 567106003628 metal binding site [ion binding]; metal-binding site 567106003629 UvrB/uvrC motif; Region: UVR; pfam02151 567106003630 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 567106003631 GMP synthase; Reviewed; Region: guaA; PRK00074 567106003632 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 567106003633 AMP/PPi binding site [chemical binding]; other site 567106003634 candidate oxyanion hole; other site 567106003635 catalytic triad [active] 567106003636 potential glutamine specificity residues [chemical binding]; other site 567106003637 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 567106003638 ATP Binding subdomain [chemical binding]; other site 567106003639 Ligand Binding sites [chemical binding]; other site 567106003640 Dimerization subdomain; other site 567106003641 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 567106003642 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 567106003643 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 567106003644 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 567106003645 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 567106003646 Predicted membrane protein/domain [Function unknown]; Region: COG1714 567106003647 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 567106003648 OstA-like protein; Region: OstA; cl00844 567106003649 Organic solvent tolerance protein; Region: OstA_C; pfam04453 567106003650 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 567106003651 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 567106003652 oligomer interface [polypeptide binding]; other site 567106003653 RNA binding site [nucleotide binding]; other site 567106003654 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 567106003655 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 567106003656 RNase E interface [polypeptide binding]; other site 567106003657 trimer interface [polypeptide binding]; other site 567106003658 active site 567106003659 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 567106003660 putative nucleic acid binding region [nucleotide binding]; other site 567106003661 G-X-X-G motif; other site 567106003662 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 567106003663 RNA binding site [nucleotide binding]; other site 567106003664 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 567106003665 putative active site [active] 567106003666 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 567106003667 active site 1 [active] 567106003668 dimer interface [polypeptide binding]; other site 567106003669 hexamer interface [polypeptide binding]; other site 567106003670 active site 2 [active] 567106003671 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 567106003672 drug efflux system protein MdtG; Provisional; Region: PRK09874 567106003673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106003674 putative substrate translocation pore; other site 567106003675 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 567106003676 Low molecular weight phosphatase family; Region: LMWPc; cd00115 567106003677 active site 567106003678 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 567106003679 chaperone protein DnaJ; Provisional; Region: PRK10767 567106003680 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 567106003681 HSP70 interaction site [polypeptide binding]; other site 567106003682 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 567106003683 substrate binding site [polypeptide binding]; other site 567106003684 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 567106003685 Zn binding sites [ion binding]; other site 567106003686 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 567106003687 dimer interface [polypeptide binding]; other site 567106003688 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 567106003689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 567106003690 active site 567106003691 phosphorylation site [posttranslational modification] 567106003692 intermolecular recognition site; other site 567106003693 dimerization interface [polypeptide binding]; other site 567106003694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 567106003695 DNA binding site [nucleotide binding] 567106003696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 567106003697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 567106003698 dimer interface [polypeptide binding]; other site 567106003699 phosphorylation site [posttranslational modification] 567106003700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 567106003701 ATP binding site [chemical binding]; other site 567106003702 Mg2+ binding site [ion binding]; other site 567106003703 G-X-G motif; other site 567106003704 recombination protein RecR; Reviewed; Region: recR; PRK00076 567106003705 RecR protein; Region: RecR; pfam02132 567106003706 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 567106003707 putative active site [active] 567106003708 putative metal-binding site [ion binding]; other site 567106003709 tetramer interface [polypeptide binding]; other site 567106003710 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 567106003711 putative substrate-binding site; other site 567106003712 nickel binding site [ion binding]; other site 567106003713 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 567106003714 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 567106003715 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 567106003716 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 567106003717 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 567106003718 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 567106003719 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 567106003720 Uncharacterized conserved protein [Function unknown]; Region: COG4121 567106003721 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 567106003722 AMIN domain; Region: AMIN; pfam11741 567106003723 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 567106003724 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 567106003725 active site 567106003726 metal binding site [ion binding]; metal-binding site 567106003727 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 567106003728 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 567106003729 FMN binding site [chemical binding]; other site 567106003730 substrate binding site [chemical binding]; other site 567106003731 putative catalytic residue [active] 567106003732 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 567106003733 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 567106003734 active site 567106003735 HIGH motif; other site 567106003736 dimer interface [polypeptide binding]; other site 567106003737 KMSKS motif; other site 567106003738 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 567106003739 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 567106003740 Zn2+ binding site [ion binding]; other site 567106003741 Mg2+ binding site [ion binding]; other site 567106003742 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 567106003743 synthetase active site [active] 567106003744 NTP binding site [chemical binding]; other site 567106003745 metal binding site [ion binding]; metal-binding site 567106003746 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 567106003747 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 567106003748 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 567106003749 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 567106003750 putative nucleotide binding site [chemical binding]; other site 567106003751 uridine monophosphate binding site [chemical binding]; other site 567106003752 homohexameric interface [polypeptide binding]; other site 567106003753 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 567106003754 Peptidase family M23; Region: Peptidase_M23; pfam01551 567106003755 FtsX-like permease family; Region: FtsX; pfam02687 567106003756 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 567106003757 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 567106003758 Walker A/P-loop; other site 567106003759 ATP binding site [chemical binding]; other site 567106003760 Q-loop/lid; other site 567106003761 ABC transporter signature motif; other site 567106003762 Walker B; other site 567106003763 D-loop; other site 567106003764 H-loop/switch region; other site 567106003765 tRNA (guanine-N(7)-)-methyltransferase; Provisional; Region: PRK14121 567106003766 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 567106003767 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 567106003768 Interdomain contacts; other site 567106003769 Cytokine receptor motif; other site 567106003770 Fibronectin type 3 domain; Region: FN3; smart00060 567106003771 Interdomain contacts; other site 567106003772 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 567106003773 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 567106003774 RNA binding surface [nucleotide binding]; other site 567106003775 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 567106003776 active site 567106003777 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 567106003778 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 567106003779 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 567106003780 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 567106003781 TrkA-N domain; Region: TrkA_N; pfam02254 567106003782 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 567106003783 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 567106003784 active site 567106003785 Malic enzyme, N-terminal domain; Region: malic; pfam00390 567106003786 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 567106003787 putative NAD(P) binding site [chemical binding]; other site 567106003788 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 567106003789 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 567106003790 active site 567106003791 HIGH motif; other site 567106003792 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 567106003793 active site 567106003794 KMSKS motif; other site 567106003795 SurA N-terminal domain; Region: SurA_N; pfam09312 567106003796 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 567106003797 biotin carboxylase; Validated; Region: PRK08462 567106003798 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 567106003799 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 567106003800 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 567106003801 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 567106003802 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 567106003803 carboxyltransferase (CT) interaction site; other site 567106003804 biotinylation site [posttranslational modification]; other site 567106003805 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 567106003806 trimer interface [polypeptide binding]; other site 567106003807 active site 567106003808 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 567106003809 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 567106003810 NAD(P) binding site [chemical binding]; other site 567106003811 homodimer interface [polypeptide binding]; other site 567106003812 substrate binding site [chemical binding]; other site 567106003813 active site 567106003814 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 567106003815 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 567106003816 inhibitor-cofactor binding pocket; inhibition site 567106003817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106003818 catalytic residue [active] 567106003819 Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain [General function prediction only]; Region: COG4310 567106003820 M28 Zn-Peptidases; Region: M28_like_3; cd05644 567106003821 active site 567106003822 metal binding site [ion binding]; metal-binding site 567106003823 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 567106003824 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 567106003825 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 567106003826 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 567106003827 Methyltransferase domain; Region: Methyltransf_23; pfam13489 567106003828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106003829 S-adenosylmethionine binding site [chemical binding]; other site 567106003830 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 567106003831 active site 567106003832 metal binding site [ion binding]; metal-binding site 567106003833 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 567106003834 HAD-superfamily phosphatase, subfamily IIIC; Region: HAD-SF-IIIC; TIGR01681 567106003835 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12880 567106003836 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 567106003837 dimer interface [polypeptide binding]; other site 567106003838 active site 567106003839 CoA binding pocket [chemical binding]; other site 567106003840 Phosphopantetheine attachment site; Region: PP-binding; cl09936 567106003841 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 567106003842 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 567106003843 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 567106003844 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 567106003845 acyl-activating enzyme (AAE) consensus motif; other site 567106003846 AMP binding site [chemical binding]; other site 567106003847 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 567106003848 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 567106003849 ligand binding site; other site 567106003850 tetramer interface; other site 567106003851 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 567106003852 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 567106003853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 567106003854 Coenzyme A binding pocket [chemical binding]; other site 567106003855 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 567106003856 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 567106003857 substrate binding site [chemical binding]; other site 567106003858 glutamase interaction surface [polypeptide binding]; other site 567106003859 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 567106003860 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 567106003861 putative active site [active] 567106003862 oxyanion strand; other site 567106003863 catalytic triad [active] 567106003864 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 567106003865 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 567106003866 Ligand Binding Site [chemical binding]; other site 567106003867 pseudaminic acid synthase; Region: PseI; TIGR03586 567106003868 NeuB family; Region: NeuB; pfam03102 567106003869 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 567106003870 NeuB binding interface [polypeptide binding]; other site 567106003871 putative substrate binding site [chemical binding]; other site 567106003872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 567106003873 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 567106003874 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 567106003875 NAD binding site [chemical binding]; other site 567106003876 substrate binding site [chemical binding]; other site 567106003877 active site 567106003878 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 567106003879 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 567106003880 inhibitor-cofactor binding pocket; inhibition site 567106003881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 567106003882 catalytic residue [active] 567106003883 N2227-like protein; Region: N2227; pfam07942 567106003884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106003885 S-adenosylmethionine binding site [chemical binding]; other site 567106003886 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 567106003887 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 567106003888 Ligand Binding Site [chemical binding]; other site 567106003889 Methyltransferase domain; Region: Methyltransf_23; pfam13489 567106003890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106003891 S-adenosylmethionine binding site [chemical binding]; other site 567106003892 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 567106003893 NeuB family; Region: NeuB; pfam03102 567106003894 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 567106003895 NeuB binding interface [polypeptide binding]; other site 567106003896 putative substrate binding site [chemical binding]; other site 567106003897 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 567106003898 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 567106003899 active site 567106003900 homodimer interface [polypeptide binding]; other site 567106003901 FOG: CBS domain [General function prediction only]; Region: COG0517 567106003902 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 567106003903 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 567106003904 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 567106003905 Substrate binding site; other site 567106003906 metal-binding site 567106003907 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 567106003908 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 567106003909 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 567106003910 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 567106003911 ligand binding site; other site 567106003912 tetramer interface; other site 567106003913 flagellin modification protein A; Provisional; Region: PRK09186 567106003914 classical (c) SDR, subgroup 8; Region: SDR_c8; cd08930 567106003915 putative NAD(P) binding site [chemical binding]; other site 567106003916 active site 567106003917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 567106003918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 567106003919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 567106003920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 567106003921 flagellin; Reviewed; Region: PRK08411 567106003922 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 567106003923 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 567106003924 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 567106003925 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 567106003926 flagellin; Reviewed; Region: PRK08411 567106003927 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 567106003928 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 567106003929 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 567106003930 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 567106003931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 567106003932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 567106003933 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 567106003934 UGMP family protein; Validated; Region: PRK09604 567106003935 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 567106003936 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 567106003937 active site 567106003938 Zn binding site [ion binding]; other site 567106003939 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 567106003940 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 567106003941 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 567106003942 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 567106003943 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 567106003944 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 567106003945 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 567106003946 Domain of unknown function (DUF814); Region: DUF814; pfam05670 567106003947 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 567106003948 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 567106003949 GTP binding site; other site 567106003950 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 567106003951 dimerization interface [polypeptide binding]; other site 567106003952 substrate binding site [chemical binding]; other site 567106003953 active site 567106003954 calcium binding site [ion binding]; other site 567106003955 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 567106003956 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 567106003957 ABC-ATPase subunit interface; other site 567106003958 dimer interface [polypeptide binding]; other site 567106003959 putative PBP binding regions; other site 567106003960 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 567106003961 ABC-ATPase subunit interface; other site 567106003962 dimer interface [polypeptide binding]; other site 567106003963 putative PBP binding regions; other site 567106003964 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 567106003965 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 567106003966 Walker A/P-loop; other site 567106003967 ATP binding site [chemical binding]; other site 567106003968 Q-loop/lid; other site 567106003969 ABC transporter signature motif; other site 567106003970 Walker B; other site 567106003971 D-loop; other site 567106003972 H-loop/switch region; other site 567106003973 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 567106003974 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 567106003975 putative ligand binding residues [chemical binding]; other site 567106003976 Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit [Inorganic ion transport and metabolism]; Region: NrfA; COG3303 567106003977 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 567106003978 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 567106003979 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 567106003980 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 567106003981 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 567106003982 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 567106003983 putative domain interface [polypeptide binding]; other site 567106003984 putative active site [active] 567106003985 catalytic site [active] 567106003986 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 567106003987 putative domain interface [polypeptide binding]; other site 567106003988 putative active site [active] 567106003989 catalytic site [active] 567106003990 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 567106003991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106003992 Walker A motif; other site 567106003993 ATP binding site [chemical binding]; other site 567106003994 Walker B motif; other site 567106003995 arginine finger; other site 567106003996 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 567106003997 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 567106003998 Domain of unknown function DUF20; Region: UPF0118; pfam01594 567106003999 fumarate hydratase; Reviewed; Region: fumC; PRK00485 567106004000 Class II fumarases; Region: Fumarase_classII; cd01362 567106004001 active site 567106004002 tetramer interface [polypeptide binding]; other site 567106004003 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 567106004004 catalytic triad [active] 567106004005 putative active site [active] 567106004006 autotransporter-associated beta strand repeat; Region: autotrns_rpt; TIGR02601 567106004007 Autotransporter beta-domain; Region: Autotransporter; pfam03797 567106004008 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 567106004009 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 567106004010 glutaminase active site [active] 567106004011 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 567106004012 dimer interface [polypeptide binding]; other site 567106004013 active site 567106004014 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 567106004015 dimer interface [polypeptide binding]; other site 567106004016 active site 567106004017 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 567106004018 hypothetical protein; Provisional; Region: PRK08444 567106004019 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 567106004020 FeS/SAM binding site; other site 567106004021 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 567106004022 Sulfate transporter family; Region: Sulfate_transp; pfam00916 567106004023 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 567106004024 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 567106004025 active site 567106004026 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 567106004027 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854 567106004028 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 567106004029 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 567106004030 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 567106004031 active site 567106004032 dimerization interface [polypeptide binding]; other site 567106004033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106004034 Major Facilitator Superfamily; Region: MFS_1; pfam07690 567106004035 putative substrate translocation pore; other site 567106004036 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 567106004037 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 567106004038 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 567106004039 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 567106004040 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 567106004041 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 567106004042 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 567106004043 G1 box; other site 567106004044 putative GEF interaction site [polypeptide binding]; other site 567106004045 GTP/Mg2+ binding site [chemical binding]; other site 567106004046 Switch I region; other site 567106004047 G2 box; other site 567106004048 G3 box; other site 567106004049 Switch II region; other site 567106004050 G4 box; other site 567106004051 G5 box; other site 567106004052 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 567106004053 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 567106004054 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 567106004055 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 567106004056 flavodoxin FldA; Validated; Region: PRK09267 567106004057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4378 567106004058 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 567106004059 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 567106004060 tetramer interface [polypeptide binding]; other site 567106004061 heme binding pocket [chemical binding]; other site 567106004062 NADPH binding site [chemical binding]; other site 567106004063 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 567106004064 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 567106004065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 567106004066 YheO-like PAS domain; Region: PAS_6; pfam08348 567106004067 HTH domain; Region: HTH_22; pfam13309 567106004068 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 567106004069 homotrimer interaction site [polypeptide binding]; other site 567106004070 putative active site [active] 567106004071 cystathionine beta-lyase, bacterial; Region: cysta_beta_ly_B; TIGR01324 567106004072 cystathionine beta-lyase, bacterial; Region: cysta_beta_ly_B; TIGR01324 567106004073 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 567106004074 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 567106004075 catalytic residue [active] 567106004076 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 567106004077 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 567106004078 tetramer interface [polypeptide binding]; other site 567106004079 active site 567106004080 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 567106004081 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 567106004082 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 567106004083 G1 box; other site 567106004084 GTP/Mg2+ binding site [chemical binding]; other site 567106004085 Switch I region; other site 567106004086 G2 box; other site 567106004087 G3 box; other site 567106004088 Switch II region; other site 567106004089 G4 box; other site 567106004090 G5 box; other site 567106004091 Nucleoside recognition; Region: Gate; pfam07670 567106004092 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 567106004093 Nucleoside recognition; Region: Gate; pfam07670 567106004094 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 567106004095 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 567106004096 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415 567106004097 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 567106004098 NAD binding site [chemical binding]; other site 567106004099 homotetramer interface [polypeptide binding]; other site 567106004100 homodimer interface [polypeptide binding]; other site 567106004101 substrate binding site [chemical binding]; other site 567106004102 active site 567106004103 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 567106004104 triosephosphate isomerase; Provisional; Region: PRK14565 567106004105 substrate binding site [chemical binding]; other site 567106004106 dimer interface [polypeptide binding]; other site 567106004107 catalytic triad [active] 567106004108 Phosphoglycerate kinase; Region: PGK; pfam00162 567106004109 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 567106004110 substrate binding site [chemical binding]; other site 567106004111 hinge regions; other site 567106004112 ADP binding site [chemical binding]; other site 567106004113 catalytic site [active] 567106004114 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 567106004115 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 567106004116 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 567106004117 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 567106004118 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 567106004119 active site 567106004120 (T/H)XGH motif; other site 567106004121 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 567106004122 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 567106004123 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 567106004124 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 567106004125 active site 567106004126 substrate binding site [chemical binding]; other site 567106004127 metal binding site [ion binding]; metal-binding site 567106004128 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK08455 567106004129 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 567106004130 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 567106004131 Cytochrome P450; Region: p450; cl12078 567106004132 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 567106004133 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 567106004134 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 567106004135 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 567106004136 ligand-binding site [chemical binding]; other site 567106004137 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 567106004138 active site 567106004139 metal-binding site 567106004140 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 567106004141 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 567106004142 conserved cys residue [active] 567106004143 hypothetical protein; Provisional; Region: PRK05849 567106004144 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 567106004145 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 567106004146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106004147 S-adenosylmethionine binding site [chemical binding]; other site 567106004148 Methyltransferase domain; Region: Methyltransf_31; pfam13847 567106004149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106004150 S-adenosylmethionine binding site [chemical binding]; other site 567106004151 Protein of unknown function (DUF2972); Region: DUF2972; pfam11186 567106004152 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 567106004153 Ligand binding site; other site 567106004154 capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689 567106004155 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 567106004156 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 567106004157 Ligand binding site; other site 567106004158 Methyltransferase domain; Region: Methyltransf_23; pfam13489 567106004159 Methyltransferase domain; Region: Methyltransf_11; pfam08241 567106004160 Cupin domain; Region: Cupin_2; cl17218 567106004161 SnoaL-like domain; Region: SnoaL_2; pfam12680 567106004162 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 567106004163 Ligand binding site; other site 567106004164 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 567106004165 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 567106004166 motif II; other site 567106004167 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar2; cd08584 567106004168 putative active site [active] 567106004169 catalytic site [active] 567106004170 Protein of unknown function (DUF2972); Region: DUF2972; pfam11186 567106004171 TPR repeat; Region: TPR_11; pfam13414 567106004172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 567106004173 TPR motif; other site 567106004174 TPR repeat; Region: TPR_11; pfam13414 567106004175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 567106004176 binding surface 567106004177 TPR motif; other site 567106004178 Tetratricopeptide repeat; Region: TPR_12; pfam13424 567106004179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 567106004180 binding surface 567106004181 Tetratricopeptide repeat; Region: TPR_16; pfam13432 567106004182 TPR motif; other site 567106004183 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 567106004184 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 567106004185 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 567106004186 putative ADP-binding pocket [chemical binding]; other site 567106004187 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 567106004188 LicD family; Region: LicD; pfam04991 567106004189 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 567106004190 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 567106004191 active site 567106004192 nucleotide binding site [chemical binding]; other site 567106004193 HIGH motif; other site 567106004194 KMSKS motif; other site 567106004195 KpsF/GutQ family protein; Region: kpsF; TIGR00393 567106004196 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 567106004197 putative active site [active] 567106004198 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 567106004199 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 567106004200 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 567106004201 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 567106004202 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 567106004203 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 567106004204 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 567106004205 Walker A/P-loop; other site 567106004206 ATP binding site [chemical binding]; other site 567106004207 Q-loop/lid; other site 567106004208 ABC transporter signature motif; other site 567106004209 Walker B; other site 567106004210 D-loop; other site 567106004211 H-loop/switch region; other site 567106004212 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 567106004213 ABC-2 type transporter; Region: ABC2_membrane; cl17235 567106004214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 567106004215 dUTPase; Region: dUTPase_2; pfam08761 567106004216 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 567106004217 active site 567106004218 homodimer interface [polypeptide binding]; other site 567106004219 metal binding site [ion binding]; metal-binding site 567106004220 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 567106004221 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 567106004222 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 567106004223 Ligand Binding Site [chemical binding]; other site 567106004224 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 567106004225 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 567106004226 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 567106004227 FeS/SAM binding site; other site 567106004228 peptide chain release factor 2; Validated; Region: prfB; PRK00578 567106004229 This domain is found in peptide chain release factors; Region: PCRF; smart00937 567106004230 RF-1 domain; Region: RF-1; pfam00472 567106004231 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 567106004232 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 567106004233 Permutation of conserved domain; other site 567106004234 active site 567106004235 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 567106004236 thiamine monophosphate kinase; Provisional; Region: PRK05731 567106004237 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 567106004238 ATP binding site [chemical binding]; other site 567106004239 dimerization interface [polypeptide binding]; other site 567106004240 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 567106004241 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 567106004242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 567106004243 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 567106004244 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 567106004245 Rod binding protein; Region: Rod-binding; cl01626 567106004246 FlgN protein; Region: FlgN; pfam05130 567106004247 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 567106004248 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 567106004249 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 567106004250 hypothetical protein; Provisional; Region: PRK10621 567106004251 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 567106004252 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 567106004253 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 567106004254 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 567106004255 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 567106004256 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 567106004257 Walker A motif; other site 567106004258 ATP binding site [chemical binding]; other site 567106004259 Walker B motif; other site 567106004260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 567106004261 AAA domain; Region: AAA_22; pfam13401 567106004262 Walker A motif; other site 567106004263 ATP binding site [chemical binding]; other site 567106004264 Walker B motif; other site 567106004265 arginine finger; other site 567106004266 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 567106004267 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 567106004268 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 567106004269 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 567106004270 dimer interface [polypeptide binding]; other site 567106004271 PYR/PP interface [polypeptide binding]; other site 567106004272 TPP binding site [chemical binding]; other site 567106004273 substrate binding site [chemical binding]; other site 567106004274 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 567106004275 Domain of unknown function; Region: EKR; pfam10371 567106004276 4Fe-4S binding domain; Region: Fer4_6; pfam12837 567106004277 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 567106004278 TPP-binding site [chemical binding]; other site 567106004279 dimer interface [polypeptide binding]; other site 567106004280 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 567106004281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 567106004282 motif II; other site 567106004283 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 567106004284 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 567106004285 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 567106004286 ligand binding site [chemical binding]; other site 567106004287 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 567106004288 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 567106004289 23S rRNA interface [nucleotide binding]; other site 567106004290 L3 interface [polypeptide binding]; other site 567106004291 Part of AAA domain; Region: AAA_19; pfam13245 567106004292 putative recombination protein RecB; Provisional; Region: PRK13909 567106004293 Family description; Region: UvrD_C_2; pfam13538 567106004294 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 567106004295 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 567106004296 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 567106004297 FixH; Region: FixH; pfam05751 567106004298 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 567106004299 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 567106004300 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 567106004301 Cytochrome c; Region: Cytochrom_C; cl11414 567106004302 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 567106004303 cytochrome c oxidase, cbb3-type, CcoQ subunit, epsilon-Proteobacterial; Region: cbb3_Q_epsi; TIGR02736 567106004304 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 567106004305 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 567106004306 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 567106004307 Low-spin heme binding site [chemical binding]; other site 567106004308 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 567106004309 D-pathway; other site 567106004310 Putative water exit pathway; other site 567106004311 Binuclear center (active site) [active] 567106004312 K-pathway; other site 567106004313 Putative proton exit pathway; other site 567106004314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 567106004315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 567106004316 active site 567106004317 phosphorylation site [posttranslational modification] 567106004318 intermolecular recognition site; other site 567106004319 dimerization interface [polypeptide binding]; other site 567106004320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 567106004321 DNA binding site [nucleotide binding] 567106004322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 567106004323 PAS domain; Region: PAS_9; pfam13426 567106004324 putative active site [active] 567106004325 heme pocket [chemical binding]; other site 567106004326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 567106004327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 567106004328 ATP binding site [chemical binding]; other site 567106004329 Mg2+ binding site [ion binding]; other site 567106004330 G-X-G motif; other site 567106004331 Uncharacterized conserved protein [Function unknown]; Region: COG2836 567106004332 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 567106004333 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 567106004334 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 567106004335 catalytic site [active] 567106004336 subunit interface [polypeptide binding]; other site 567106004337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2952 567106004338 Uncharacterized conserved protein [Function unknown]; Region: COG3334 567106004339 Flagellar FliJ protein; Region: FliJ; pfam02050 567106004340 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 567106004341 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 567106004342 GDP-binding site [chemical binding]; other site 567106004343 ACT binding site; other site 567106004344 IMP binding site; other site 567106004345 putative inner membrane protein; Provisional; Region: PRK11099 567106004346 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 567106004347 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 567106004348 CPxP motif; other site 567106004349 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 567106004350 Na binding site [ion binding]; other site 567106004351 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 567106004352 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 567106004353 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 567106004354 Glutamate binding site [chemical binding]; other site 567106004355 NAD binding site [chemical binding]; other site 567106004356 catalytic residues [active] 567106004357 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 567106004358 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 567106004359 dimerization interface [polypeptide binding]; other site 567106004360 putative ATP binding site [chemical binding]; other site 567106004361 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 567106004362 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 567106004363 CPxP motif; other site 567106004364 Cache domain; Region: Cache_1; pfam02743 567106004365 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 567106004366 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 567106004367 dimer interface [polypeptide binding]; other site 567106004368 putative CheW interface [polypeptide binding]; other site 567106004369 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 567106004370 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 567106004371 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 567106004372 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 567106004373 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 567106004374 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 567106004375 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 567106004376 [4Fe-4S] binding site [ion binding]; other site 567106004377 molybdopterin cofactor binding site; other site 567106004378 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 567106004379 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 567106004380 molybdopterin cofactor binding site; other site 567106004381 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 567106004382 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 567106004383 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 567106004384 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 567106004385 dimer interface [polypeptide binding]; other site 567106004386 active site 567106004387 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 567106004388 catalytic residues [active] 567106004389 substrate binding site [chemical binding]; other site 567106004390 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 567106004391 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 567106004392 Multicopper oxidase; Region: Cu-oxidase; pfam00394 567106004393 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 567106004394 ThiS family; Region: ThiS; pfam02597 567106004395 charged pocket; other site 567106004396 hydrophobic patch; other site 567106004397 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 567106004398 MoaE homodimer interface [polypeptide binding]; other site 567106004399 MoaD interaction [polypeptide binding]; other site 567106004400 active site residues [active] 567106004401 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 567106004402 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 567106004403 dimer interface [polypeptide binding]; other site 567106004404 putative functional site; other site 567106004405 putative MPT binding site; other site 567106004406 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 567106004407 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 567106004408 Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513 567106004409 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 567106004410 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 567106004411 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 567106004412 dimerization interface [polypeptide binding]; other site 567106004413 putative ATP binding site [chemical binding]; other site 567106004414 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 567106004415 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 567106004416 CoA-binding site [chemical binding]; other site 567106004417 ATP-binding [chemical binding]; other site 567106004418 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 567106004419 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 567106004420 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 567106004421 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 567106004422 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 567106004423 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 567106004424 AAA domain; Region: AAA_14; pfam13173 567106004425 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 567106004426 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 567106004427 dimerization interface [polypeptide binding]; other site 567106004428 DPS ferroxidase diiron center [ion binding]; other site 567106004429 ion pore; other site 567106004430 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 567106004431 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 567106004432 active site 567106004433 dimer interface [polypeptide binding]; other site 567106004434 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 567106004435 dimer interface [polypeptide binding]; other site 567106004436 active site 567106004437 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 567106004438 active site 567106004439 tetramer interface; other site 567106004440 acetyl-CoA synthetase; Provisional; Region: PRK00174 567106004441 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 567106004442 active site 567106004443 CoA binding site [chemical binding]; other site 567106004444 acyl-activating enzyme (AAE) consensus motif; other site 567106004445 AMP binding site [chemical binding]; other site 567106004446 acetate binding site [chemical binding]; other site 567106004447 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 567106004448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 567106004449 Walker A/P-loop; other site 567106004450 ATP binding site [chemical binding]; other site 567106004451 Q-loop/lid; other site 567106004452 ABC transporter signature motif; other site 567106004453 Walker B; other site 567106004454 D-loop; other site 567106004455 H-loop/switch region; other site 567106004456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106004457 dimer interface [polypeptide binding]; other site 567106004458 conserved gate region; other site 567106004459 putative PBP binding loops; other site 567106004460 ABC-ATPase subunit interface; other site 567106004461 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 567106004462 PBP superfamily domain; Region: PBP_like_2; pfam12849 567106004463 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 567106004464 putative active site [active] 567106004465 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 567106004466 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 567106004467 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 567106004468 EamA-like transporter family; Region: EamA; pfam00892 567106004469 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 567106004470 Predicted transcriptional regulators [Transcription]; Region: COG1733 567106004471 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 567106004472 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 567106004473 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 567106004474 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 567106004475 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 567106004476 putative NAD(P) binding site [chemical binding]; other site 567106004477 putative substrate binding site [chemical binding]; other site 567106004478 catalytic Zn binding site [ion binding]; other site 567106004479 structural Zn binding site [ion binding]; other site 567106004480 dimer interface [polypeptide binding]; other site 567106004481 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 567106004482 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 567106004483 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 567106004484 ATP binding site [chemical binding]; other site 567106004485 putative Mg++ binding site [ion binding]; other site 567106004486 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 567106004487 AAA domain; Region: AAA_21; pfam13304 567106004488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 567106004489 ABC transporter signature motif; other site 567106004490 Walker B; other site 567106004491 D-loop; other site 567106004492 H-loop/switch region; other site 567106004493 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 567106004494 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 567106004495 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 567106004496 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 567106004497 Divergent AAA domain; Region: AAA_4; pfam04326 567106004498 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 567106004499 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 567106004500 HsdM N-terminal domain; Region: HsdM_N; pfam12161 567106004501 Methyltransferase domain; Region: Methyltransf_26; pfam13659 567106004502 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 567106004503 NADH(P)-binding; Region: NAD_binding_10; pfam13460 567106004504 NAD binding site [chemical binding]; other site 567106004505 substrate binding site [chemical binding]; other site 567106004506 putative active site [active] 567106004507 Predicted transcriptional regulators [Transcription]; Region: COG1733 567106004508 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 567106004509 dimerization interface [polypeptide binding]; other site 567106004510 putative DNA binding site [nucleotide binding]; other site 567106004511 putative Zn2+ binding site [ion binding]; other site 567106004512 potential frameshift: common BLAST hit: gi|57238573|ref|YP_179704.1| permease 567106004513 Predicted permeases [General function prediction only]; Region: COG0701 567106004514 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 567106004515 dimerization interface [polypeptide binding]; other site 567106004516 putative DNA binding site [nucleotide binding]; other site 567106004517 putative Zn2+ binding site [ion binding]; other site 567106004518 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 567106004519 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 567106004520 DNA binding residues [nucleotide binding] 567106004521 putative dimer interface [polypeptide binding]; other site 567106004522 Cache domain; Region: Cache_1; pfam02743 567106004523 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 567106004524 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 567106004525 dimer interface [polypeptide binding]; other site 567106004526 putative CheW interface [polypeptide binding]; other site 567106004527 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15490 567106004528 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 567106004529 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 567106004530 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 567106004531 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 567106004532 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 567106004533 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 567106004534 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 567106004535 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713 567106004536 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 567106004537 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 567106004538 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 567106004539 4Fe-4S binding domain; Region: Fer4; cl02805 567106004540 4Fe-4S binding domain; Region: Fer4; pfam00037 567106004541 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 567106004542 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 567106004543 NADH dehydrogenase subunit G; Validated; Region: PRK08493 567106004544 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 567106004545 catalytic loop [active] 567106004546 iron binding site [ion binding]; other site 567106004547 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 567106004548 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 567106004549 NADH dehydrogenase subunit D; Validated; Region: PRK06075 567106004550 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 567106004551 NADH dehydrogenase subunit C; Provisional; Region: PRK08491 567106004552 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 567106004553 NADH dehydrogenase subunit B; Validated; Region: PRK06411 567106004554 NADH dehydrogenase subunit A; Validated; Region: PRK08489 567106004555 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 567106004556 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 567106004557 Walker A/P-loop; other site 567106004558 ATP binding site [chemical binding]; other site 567106004559 Q-loop/lid; other site 567106004560 ABC transporter signature motif; other site 567106004561 Walker B; other site 567106004562 D-loop; other site 567106004563 H-loop/switch region; other site 567106004564 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 567106004565 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 567106004566 Walker A/P-loop; other site 567106004567 ATP binding site [chemical binding]; other site 567106004568 Q-loop/lid; other site 567106004569 ABC transporter signature motif; other site 567106004570 Walker B; other site 567106004571 D-loop; other site 567106004572 H-loop/switch region; other site 567106004573 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 567106004574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 567106004575 putative PBP binding loops; other site 567106004576 ABC-ATPase subunit interface; other site 567106004577 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 567106004578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 567106004579 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 567106004580 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 567106004581 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 567106004582 FAD binding domain; Region: FAD_binding_4; pfam01565 567106004583 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 567106004584 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 567106004585 heme-binding site [chemical binding]; other site 567106004586 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 567106004587 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 567106004588 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 567106004589 Walker A/P-loop; other site 567106004590 ATP binding site [chemical binding]; other site 567106004591 Q-loop/lid; other site 567106004592 ABC transporter signature motif; other site 567106004593 Walker B; other site 567106004594 D-loop; other site 567106004595 H-loop/switch region; other site 567106004596 metabolite-proton symporter; Region: 2A0106; TIGR00883 567106004597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106004598 putative substrate translocation pore; other site 567106004599 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 567106004600 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 567106004601 rRNA binding site [nucleotide binding]; other site 567106004602 predicted 30S ribosome binding site; other site 567106004603 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 567106004604 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 567106004605 30S ribosomal protein S13; Region: bact_S13; TIGR03631 567106004606 30S ribosomal protein S11; Validated; Region: PRK05309 567106004607 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 567106004608 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 567106004609 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 567106004610 RNA binding surface [nucleotide binding]; other site 567106004611 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 567106004612 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 567106004613 alphaNTD homodimer interface [polypeptide binding]; other site 567106004614 alphaNTD - beta interaction site [polypeptide binding]; other site 567106004615 alphaNTD - beta' interaction site [polypeptide binding]; other site 567106004616 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 567106004617 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 567106004618 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 567106004619 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 567106004620 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 567106004621 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 567106004622 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 567106004623 NAD binding site [chemical binding]; other site 567106004624 dimerization interface [polypeptide binding]; other site 567106004625 product binding site; other site 567106004626 substrate binding site [chemical binding]; other site 567106004627 zinc binding site [ion binding]; other site 567106004628 catalytic residues [active] 567106004629 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 567106004630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 567106004631 active site 567106004632 motif I; other site 567106004633 motif II; other site 567106004634 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 567106004635 putative active site pocket [active] 567106004636 4-fold oligomerization interface [polypeptide binding]; other site 567106004637 metal binding residues [ion binding]; metal-binding site 567106004638 3-fold/trimer interface [polypeptide binding]; other site 567106004639 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 567106004640 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 567106004641 putative active site [active] 567106004642 oxyanion strand; other site 567106004643 catalytic triad [active] 567106004644 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 567106004645 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 567106004646 catalytic residues [active] 567106004647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2958 567106004648 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 567106004649 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 567106004650 substrate binding site [chemical binding]; other site 567106004651 glutamase interaction surface [polypeptide binding]; other site 567106004652 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 567106004653 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 567106004654 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 567106004655 metal binding site [ion binding]; metal-binding site 567106004656 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 567106004657 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 567106004658 putative trimer interface [polypeptide binding]; other site 567106004659 putative CoA binding site [chemical binding]; other site 567106004660 antiporter inner membrane protein; Provisional; Region: PRK11670 567106004661 Domain of unknown function DUF59; Region: DUF59; pfam01883 567106004662 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 567106004663 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 567106004664 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 567106004665 substrate binding site; other site 567106004666 dimer interface; other site 567106004667 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 567106004668 homotrimer interaction site [polypeptide binding]; other site 567106004669 zinc binding site [ion binding]; other site 567106004670 CDP-binding sites; other site 567106004671 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 567106004672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 567106004673 active site 567106004674 intermolecular recognition site; other site 567106004675 dimerization interface [polypeptide binding]; other site 567106004676 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046 567106004677 ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747 567106004678 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 567106004679 tetramer interfaces [polypeptide binding]; other site 567106004680 binuclear metal-binding site [ion binding]; other site 567106004681 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 567106004682 peptide chain release factor 1; Validated; Region: prfA; PRK00591 567106004683 This domain is found in peptide chain release factors; Region: PCRF; smart00937 567106004684 RF-1 domain; Region: RF-1; pfam00472 567106004685 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 567106004686 heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109 567106004687 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 567106004688 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 567106004689 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 567106004690 N-terminal plug; other site 567106004691 ligand-binding site [chemical binding]; other site 567106004692 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 567106004693 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 567106004694 ABC-ATPase subunit interface; other site 567106004695 dimer interface [polypeptide binding]; other site 567106004696 putative PBP binding regions; other site 567106004697 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 567106004698 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 567106004699 Walker A/P-loop; other site 567106004700 ATP binding site [chemical binding]; other site 567106004701 Q-loop/lid; other site 567106004702 ABC transporter signature motif; other site 567106004703 Walker B; other site 567106004704 D-loop; other site 567106004705 H-loop/switch region; other site 567106004706 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 567106004707 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 567106004708 putative binding site residues; other site 567106004709 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 567106004710 FeS/SAM binding site; other site 567106004711 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 567106004712 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 567106004713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106004714 putative substrate translocation pore; other site 567106004715 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 567106004716 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 567106004717 minor groove reading motif; other site 567106004718 helix-hairpin-helix signature motif; other site 567106004719 substrate binding pocket [chemical binding]; other site 567106004720 active site 567106004721 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 567106004722 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 567106004723 catalytic motif [active] 567106004724 Zn binding site [ion binding]; other site 567106004725 RibD C-terminal domain; Region: RibD_C; cl17279 567106004726 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 567106004727 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 567106004728 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 567106004729 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 567106004730 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 567106004731 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 567106004732 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 567106004733 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 567106004734 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 567106004735 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 567106004736 TonB system transport protein ExbD, group 2; Region: ExbD_2; TIGR02804 567106004737 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 567106004738 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 567106004739 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 567106004740 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 567106004741 Ligand Binding Site [chemical binding]; other site 567106004742 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 567106004743 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 567106004744 Tetramer interface [polypeptide binding]; other site 567106004745 active site 567106004746 FMN-binding site [chemical binding]; other site 567106004747 ribonuclease III; Reviewed; Region: rnc; PRK00102 567106004748 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 567106004749 dimerization interface [polypeptide binding]; other site 567106004750 active site 567106004751 metal binding site [ion binding]; metal-binding site 567106004752 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 567106004753 dsRNA binding site [nucleotide binding]; other site 567106004754 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 567106004755 RNA/DNA hybrid binding site [nucleotide binding]; other site 567106004756 active site 567106004757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 567106004758 TPR motif; other site 567106004759 binding surface 567106004760 Tetratricopeptide repeat; Region: TPR_16; pfam13432 567106004761 Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have...; Region: ZZ; cl00295 567106004762 Zinc-binding sites [ion binding]; other site 567106004763 zinc cluster 1 [ion binding]; other site 567106004764 putative charged binding surface; other site 567106004765 putative hydrophobic binding surface; other site 567106004766 zinc cluster 2 [ion binding]; other site 567106004767 DNA primase, catalytic core; Region: dnaG; TIGR01391 567106004768 CHC2 zinc finger; Region: zf-CHC2; pfam01807 567106004769 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 567106004770 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 567106004771 active site 567106004772 metal binding site [ion binding]; metal-binding site 567106004773 interdomain interaction site; other site 567106004774 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 567106004775 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 567106004776 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 567106004777 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 567106004778 hypothetical protein; Provisional; Region: PRK03762 567106004779 PDZ domain; Region: PDZ_2; pfam13180 567106004780 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 567106004781 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 567106004782 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 567106004783 substrate binding pocket [chemical binding]; other site 567106004784 chain length determination region; other site 567106004785 substrate-Mg2+ binding site; other site 567106004786 catalytic residues [active] 567106004787 aspartate-rich region 1; other site 567106004788 active site lid residues [active] 567106004789 aspartate-rich region 2; other site 567106004790 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 567106004791 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 567106004792 TPP-binding site [chemical binding]; other site 567106004793 dimer interface [polypeptide binding]; other site 567106004794 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 567106004795 PYR/PP interface [polypeptide binding]; other site 567106004796 dimer interface [polypeptide binding]; other site 567106004797 TPP binding site [chemical binding]; other site 567106004798 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 567106004799 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 567106004800 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 567106004801 Permease; Region: Permease; pfam02405 567106004802 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 567106004803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 567106004804 Walker A/P-loop; other site 567106004805 ATP binding site [chemical binding]; other site 567106004806 Q-loop/lid; other site 567106004807 ABC transporter signature motif; other site 567106004808 Walker B; other site 567106004809 D-loop; other site 567106004810 H-loop/switch region; other site 567106004811 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 567106004812 mce related protein; Region: MCE; pfam02470 567106004813 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 567106004814 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 567106004815 active site 567106004816 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 567106004817 NlpC/P60 family; Region: NLPC_P60; pfam00877 567106004818 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 567106004819 Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004 567106004820 Putative motility protein; Region: YjfB_motility; pfam14070 567106004821 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 567106004822 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 567106004823 Predicted membrane protein [Function unknown]; Region: COG4393 567106004824 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 567106004825 Uncharacterized conserved protein [Function unknown]; Region: COG3350 567106004826 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 567106004827 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 567106004828 FtsX-like permease family; Region: FtsX; pfam02687 567106004829 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 567106004830 FtsX-like permease family; Region: FtsX; pfam02687 567106004831 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 567106004832 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 567106004833 Walker A/P-loop; other site 567106004834 ATP binding site [chemical binding]; other site 567106004835 Q-loop/lid; other site 567106004836 ABC transporter signature motif; other site 567106004837 Walker B; other site 567106004838 D-loop; other site 567106004839 H-loop/switch region; other site 567106004840 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 567106004841 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 567106004842 catalytic residues [active] 567106004843 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 567106004844 Predicted metal-binding protein [General function prediction only]; Region: COG3019 567106004845 DNA ligase; Provisional; Region: PRK09125 567106004846 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 567106004847 DNA binding site [nucleotide binding] 567106004848 active site 567106004849 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 567106004850 DNA binding site [nucleotide binding] 567106004851 AMIN domain; Region: AMIN; pfam11741 567106004852 enolase; Provisional; Region: eno; PRK00077 567106004853 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 567106004854 dimer interface [polypeptide binding]; other site 567106004855 metal binding site [ion binding]; metal-binding site 567106004856 substrate binding pocket [chemical binding]; other site 567106004857 recombinase A; Provisional; Region: recA; PRK09354 567106004858 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 567106004859 hexamer interface [polypeptide binding]; other site 567106004860 Walker A motif; other site 567106004861 ATP binding site [chemical binding]; other site 567106004862 Walker B motif; other site 567106004863 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 567106004864 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 567106004865 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 567106004866 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 567106004867 Autotransporter beta-domain; Region: Autotransporter; smart00869 567106004868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 567106004869 binding surface 567106004870 TPR motif; other site 567106004871 TPR repeat; Region: TPR_11; pfam13414 567106004872 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 567106004873 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 567106004874 active site 567106004875 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 567106004876 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 567106004877 dimer interface [polypeptide binding]; other site 567106004878 active site 567106004879 citrylCoA binding site [chemical binding]; other site 567106004880 NADH binding [chemical binding]; other site 567106004881 cationic pore residues; other site 567106004882 oxalacetate/citrate binding site [chemical binding]; other site 567106004883 coenzyme A binding site [chemical binding]; other site 567106004884 catalytic triad [active] 567106004885 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 567106004886 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 567106004887 biotin synthase; Provisional; Region: PRK08508 567106004888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 567106004889 FeS/SAM binding site; other site 567106004890 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 567106004891 DNA topoisomerase I; Validated; Region: PRK05582 567106004892 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 567106004893 active site 567106004894 interdomain interaction site; other site 567106004895 putative metal-binding site [ion binding]; other site 567106004896 nucleotide binding site [chemical binding]; other site 567106004897 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 567106004898 domain I; other site 567106004899 DNA binding groove [nucleotide binding] 567106004900 phosphate binding site [ion binding]; other site 567106004901 domain II; other site 567106004902 domain III; other site 567106004903 nucleotide binding site [chemical binding]; other site 567106004904 catalytic site [active] 567106004905 domain IV; other site 567106004906 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 567106004907 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 567106004908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 567106004909 putative substrate translocation pore; other site 567106004910 Major Facilitator Superfamily; Region: MFS_1; pfam07690 567106004911 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 567106004912 SecY translocase; Region: SecY; pfam00344 567106004913 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 567106004914 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 567106004915 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 567106004916 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 567106004917 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 567106004918 5S rRNA interface [nucleotide binding]; other site 567106004919 23S rRNA interface [nucleotide binding]; other site 567106004920 L5 interface [polypeptide binding]; other site 567106004921 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 567106004922 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 567106004923 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 567106004924 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 567106004925 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 567106004926 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 567106004927 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 567106004928 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 567106004929 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 567106004930 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 567106004931 RNA binding site [nucleotide binding]; other site 567106004932 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 567106004933 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 567106004934 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 567106004935 putative translocon interaction site; other site 567106004936 23S rRNA interface [nucleotide binding]; other site 567106004937 signal recognition particle (SRP54) interaction site; other site 567106004938 L23 interface [polypeptide binding]; other site 567106004939 trigger factor interaction site; other site 567106004940 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 567106004941 23S rRNA interface [nucleotide binding]; other site 567106004942 5S rRNA interface [nucleotide binding]; other site 567106004943 putative antibiotic binding site [chemical binding]; other site 567106004944 L25 interface [polypeptide binding]; other site 567106004945 L27 interface [polypeptide binding]; other site 567106004946 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 567106004947 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 567106004948 G-X-X-G motif; other site 567106004949 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 567106004950 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 567106004951 putative translocon binding site; other site 567106004952 protein-rRNA interface [nucleotide binding]; other site 567106004953 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 567106004954 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 567106004955 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 567106004956 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 567106004957 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 567106004958 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 567106004959 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 567106004960 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 567106004961 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 567106004962 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 567106004963 RNA binding surface [nucleotide binding]; other site 567106004964 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 567106004965 active site 567106004966 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 567106004967 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 567106004968 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 567106004969 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 567106004970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 567106004971 S-adenosylmethionine binding site [chemical binding]; other site 567106004972 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 567106004973 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 567106004974 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 567106004975 FeS/SAM binding site; other site 567106004976 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 567106004977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 567106004978 Coenzyme A binding pocket [chemical binding]; other site 567106004979 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 567106004980 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 567106004981 substrate binding site [chemical binding]; other site 567106004982 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 567106004983 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 567106004984 substrate binding site [chemical binding]; other site 567106004985 ligand binding site [chemical binding]; other site 567106004986 tartrate dehydrogenase; Region: TTC; TIGR02089 567106004987 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 567106004988 2-isopropylmalate synthase; Validated; Region: PRK00915 567106004989 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 567106004990 active site 567106004991 catalytic residues [active] 567106004992 metal binding site [ion binding]; metal-binding site 567106004993 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 567106004994 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 567106004995 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 567106004996 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 567106004997 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 567106004998 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 567106004999 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 567106005000 active site 567106005001 putative DNA-binding cleft [nucleotide binding]; other site 567106005002 dimer interface [polypeptide binding]; other site 567106005003 VirB8 protein; Region: VirB8; cl01500 567106005004 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 567106005005 VirB7 interaction site; other site 567106005006 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 567106005007 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 567106005008 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 567106005009 Walker A motif; other site 567106005010 hexamer interface [polypeptide binding]; other site 567106005011 ATP binding site [chemical binding]; other site 567106005012 Walker B motif; other site 567106005013 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 567106005014 Protein of unknown function (DUF418); Region: DUF418; pfam04235 567106005015 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 567106005016 Walker A motif; other site 567106005017 ATP binding site [chemical binding]; other site 567106005018 Walker B motif; other site 567106005019 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 567106005020 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 567106005021 TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028 567106005022 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 567106005023 active site 567106005024 interdomain interaction site; other site 567106005025 putative metal-binding site [ion binding]; other site 567106005026 nucleotide binding site [chemical binding]; other site 567106005027 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 567106005028 domain I; other site 567106005029 DNA binding groove [nucleotide binding] 567106005030 phosphate binding site [ion binding]; other site 567106005031 domain II; other site 567106005032 domain III; other site 567106005033 nucleotide binding site [chemical binding]; other site 567106005034 catalytic site [active] 567106005035 domain IV; other site 567106005036 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 567106005037 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 567106005038 dimer interface [polypeptide binding]; other site 567106005039 ssDNA binding site [nucleotide binding]; other site 567106005040 tetramer (dimer of dimers) interface [polypeptide binding]; other site 567106005041 YopX protein; Region: YopX; cl09859 567106005042 ParA-like protein; Provisional; Region: PHA02518 567106005043 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 567106005044 P-loop; other site 567106005045 Magnesium ion binding site [ion binding]; other site 567106005046 Initiator Replication protein; Region: Rep_3; pfam01051 567106005047 TrbM; Region: TrbM; pfam07424 567106005048 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 567106005049 Toprim-like; Region: Toprim_2; pfam13155 567106005050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 567106005051 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 567106005052 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 567106005053 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 567106005054 AAA domain; Region: AAA_17; pfam13207 567106005055 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 567106005056 Walker B motif; other site