-- dump date 20120504_140605 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_002343473.1 218561694 904342 1..1323 1 NC_002163.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1323 dnaA 904342 dnaA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 chromosomal replication initiation protein YP_002343473.1 1 D 192222 CDS YP_002343474.1 218561695 904340 1483..2550 1 NC_002163.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2550 dnaN 904340 dnaN Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA polymerase III subunit beta YP_002343474.1 1483 D 192222 CDS YP_002343475.1 218561696 904343 2579..4888 1 NC_002163.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 4888 gyrB 904343 gyrB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA gyrase subunit B YP_002343475.1 2579 D 192222 CDS YP_002343476.1 218561697 904344 complement(4916..5257) 1 NC_002163.1 Original (2000) note: Cj0004c, possible periplasmic protein, len: 113 aa. No Hp match. Contains possible N-terminal signal sequence; Updated (2006) note: NCTC11168 Cj0004c encodes a monohaem cytochrome C (PMID:15632441). Together with Cj0005 (molybdopterin oxidoreductase), they are homologous to sulphite:cytochrome C oxidoreductase (SOR) of Starkeya novella (PMID:11557133). Cj0004 mutants showed wild-type rates of formate-dependent respiration but were unable to respire with sulphite or metabisulphite as electron donors. Periplasmic extracts of wild-type NCTC11168 showed a symmetrical absorption peak (552nm) after addition of sulphite, demonstrating the reduction of cytochrome C. No cytochrome C reduction was observed after addition of sulphite to periplasmic extracts of the Cj0004c mutant (PMID:15632441). Characterised within Campylobacter jejuni, so not added to product function. Functional classification - Energy metabolism -Respiration - Electron transport; PMID:15632441; monohaem cytochrome C 5257 904344 Cj0004c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 monohaem cytochrome C YP_002343476.1 4916 R 192222 CDS YP_002343477.1 218561698 904345 complement(5260..6498) 1 NC_002163.1 Original (2000) note: Cj0005c, possible molybdenum containing oxidoreductase, len: 412 aa; similar to many eukaryotic oxidoreductases e.g. SUOX_HUMAN sulfite oxidase precursor (488 aa), fasta scores; opt: 543 z-score: 338.2 E(): 1.4e-11, 29.8% identity in 372 aa overlap and NIA_PETHY nitrate reductase from Petunia hybrida (909 aa),fasta scores; opt: 281 z-score: 312.5 E(): 3.8e-10, 28.9% identity in 395 aa overlap. No Hp match. Contains Pfam match to entry PF00174 oxidored_molyb, Oxidoreductase molybdopterin binding domain, score 45.20, E-value 1e-12; Updated (2006) note: Pfam domain PF03404 Mo-co oxidoreductase dimerisation domain identified within CDS. One probable transmembrane helix predicted by TMHMM2.0. Further support given to product function. Supporting paper identified showing interaction with Cj0004c (PMID:15632441). Product function modified to more specific family member based on characterisation paper. Functional classification - Misc; PMID:15632441; molydopterin containing oxidoreductase 6498 904345 Cj0005c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molydopterin containing oxidoreductase YP_002343477.1 5260 R 192222 CDS YP_002343478.1 218561699 904346 6703..8010 1 NC_002163.1 Original (2000) note: Cj0006, probable integral membrane protein, len: 435 aa; similar to e.g. Y325_HAEIN hypothetical protein HI0325 (450 aa), fasta scores; opt: 757 z-score: 1654.9 E(): 0, 44.0% identity in 450 aa overlap. 47.2% identity to HP0758; Updated (2006) note: Pfam domain PF03553 Na+/H+ antiporter family identified within CDS. Product modified to more specific family member due to motif match. Also,eleven probable transmembrane helices predicted by TMHMM2.0 giving further support to product function. No specific characterisation with acceptable identity score has been carried out yet. Thus, kept within product function. Functional classification -Transport/binding proteins - Cations; Na+/H+ antiporter family protein 8010 904346 Cj0006 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Na+/H+ antiporter family protein YP_002343478.1 6703 D 192222 CDS YP_002343479.1 218561700 904339 8144..12634 1 NC_002163.1 Original (2000) note: Cj0007, gltB, probable glutamate synthase (NADPH) large subunit, len: 1496 aa; similar to many e.g. GLTB_ECOLI glutamate synthase (NADPH) large chain (1517 aa), fasta scores; opt: 3846 z-score: 3828.3 E(): 0, 42.5% identity in 1488 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF00310 Glutamine amidotransferases class-II, PF04898 Glutamate synthase central domain, PF01645 Conserved region in glutamate synthase and PF01493 GXGXG motif were all identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with acceptable identity score. Thus, not added to product function. Functional classification - Central intermediary metabolism - General; PMID:2548995, PMID:11029411; glutamate synthase large subunit 12634 gltB 904339 gltB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glutamate synthase large subunit YP_002343479.1 8144 D 192222 CDS YP_002343480.1 218561701 904337 12644..14395 1 NC_002163.1 Original (2000) note: Cj0008, unknown, len: 583 aa; similar to Y686_METJA hypothetical protein MJ0686 (580 aa), fasta scores; opt: 171 z-score: 228.3 E(): 1.9e-05,22.8% identity in 609 aa overlap. 37.5% identity in N-term to HP0938, 30.0% identity in C-term to HP0937; Updated (2006) note: Pfam PF03235 Protein of unknown function (DUF262), was present within CDS. Conserved added to product function as motif was identified. Functional classification - Conserved hypothetical proteins; hypothetical protein 14395 904337 Cj0008 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343480.1 12644 D 192222 CDS YP_002343481.1 218561702 904336 14398..15843 1 NC_002163.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 15843 gltD 904336 gltD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glutamate synthase subunit beta YP_002343481.1 14398 D 192222 CDS YP_002343482.1 218561703 904334 complement(15844..16419) 1 NC_002163.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 16419 rnhB 904334 rnhB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribonuclease HII YP_002343482.1 15844 R 192222 CDS YP_002343483.1 218561704 904332 complement(16452..16691) 1 NC_002163.1 Updated (2006) note: Characterisation work carried out within Bacillus subtilis, however, sequence alignment was only partial. kept within product function; Original (2000) note: Cj0011c, possible non-specific DNA binding protein, len: 79 aa; similar to the C-terminus of CME1_BACSU comE operon protein 1 (comeA) (205 aa), fasta scores; opt: 223 z-score: 359.5 E(): 9e-13, 56.9% identity in 65 aa overlap. No Hp match. Contains Pfam match to entry PF00633 HHH,Helix-hairpin-helix motif., score 31.80, E-value 1.6e-05; PMID:7968523, PMID:7768800; non-specific DNA binding protein 16691 904332 Cj0011c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 non-specific DNA binding protein YP_002343483.1 16452 R 192222 CDS YP_002343484.1 218561705 904330 complement(16756..17403) 1 NC_002163.1 Original (2000) note: Cj0012c, non-haem iron protein, len: 215 aa; has three possible iron-binding domains; C-terminus is similar to rubrerythrins e.g. RUBY_DESVH rubrerythrin (191 aa), fasta scores; opt: 454 z-score: 746.8 E(): 0, 39.5% identity in 190 aa overlap,with the iron-binding residues of both the rubredoxin-like center non-sulfur oxo-bridged di-iron center conserved. N-terminal 33 aa are simialar to the iron-bindingdomain of desulfoferrodoxins e.g. DESR_DESVH desulfoferrodoxin (125 aa), fasta scores; opt: 161 z-score: 275.8 E(): 4.2e-08,68.8% identity in 32 aa overlap, with the iron-binding residues conserved. No Hp match; Updated (2006) note: Pfam domains PF00301 Rubredoxin, PF02915 Rubrerythrin and PF06397 Desulfoferrodoxin, N-terminal domain were all identified within CDS. Further support given to product function. Characterisation paper within Campylobacter also identified allowing gene name to be designated as Rrc (Rbo/Rbr-like protein of C. jejuni) protein. Thus, not added to product function. Functional classification - Transport/binding proteins - Cations; PMID:15158262; non-haem iron protein 17403 rrc 904330 rrc Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 non-haem iron protein YP_002343484.1 16756 R 192222 CDS YP_002343485.1 218561706 904349 17563..19239 1 NC_002163.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 19239 ilvD 904349 ilvD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dihydroxy-acid dehydratase YP_002343485.1 17563 D 192222 CDS YP_002343486.1 218561707 904347 complement(19251..19775) 1 NC_002163.1 Original (2000) note: Cj0014c, probable integral membrane protein, len: 174 aa; similar to YAGU_ECOLI hypothetical 23.0 kd protein in intF-eaeH intergenic region (204 aa), fasta scores; opt: 402 z-score: 821.6 E(): 0, 45.1% identity in 184 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF07274 Protein of unknown function (DUF1440) identified within CDS. Also,three probable transmembrane helices identified by TMHMM2.0. Further support given to product function. No specific characterisation has been carried out yet. Thus, kept within product function. Functional classification - Central intermediary metabolism -General; integral membrane protein 19775 904347 Cj0014c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343486.1 19251 R 192222 CDS YP_002343487.1 218561708 904352 complement(19867..21093) 1 NC_002163.1 Original (2000) note: Cj0015c, unknown, len: 408 aa; 35.4% identity to HP0711; Updated (2006) note: Literature search identified paper (PMID:15647906) giving potential clues to product functionality. Functional classification - Conserved hypothetical proteins; PMID:15647906; hypothetical protein 21093 904352 Cj0015c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343487.1 19867 R 192222 CDS YP_002343488.1 218561709 904353 21159..21833 1 NC_002163.1 Original (2000) note: Cj0016, possible transcriptional regulatory protein, len: 224 aa; similar to many hypothetical proteins and to TR:Q52925 (EMBL:Z50189) Rhizobium meliloti succinoglycan biosynthesis regulator exsB (234 aa), fasta scores; opt: 284 z-score: 395.5 E(): 9e-15, 33.5% identity in 191 aa overlap. 33.9% identity to HP0639 conserved hypothetical protein; Updated (2006) note: Pfam domain PF06508 ExsB identified within CDS. Further support given to product function. Characterisation work carried out within Pseudomonas aeruginosa, however, identity scores were not acceptable. Thus, kept within product function. Functional classification - Broad regulatory functions; PMID:9045825, PMID:8544814; transcriptional regulatory protein 21833 904353 Cj0016 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcriptional regulatory protein YP_002343488.1 21159 D 192222 CDS YP_002343489.1 218561710 904354 complement(21854..23380) 1 NC_002163.1 Original (2000) note: Cj0017c, probable ATP/GTP binding protein, len: 508 aa; 37.4% identity to HP0595 hypothetical protein. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Pfam domain PF02600 Disulfide bond formation protein DsbB identified within CDS. Gram negative bacterial cells have disulfide bond formation occuring in the oxidative environment of the periplasm and are catalysed by Dsb (disulfide bond) proteins found in the periplasm and in the inner membrane. Supporting paper (PMID:15632440) demonstrates via deletion and complementation that Cj0017c is part of the DsbB family and has been designated as dsbI. There is also strong evidence that Cj0017c and upstream ORF Cj0018c are co-transcribed (PMID:15632440). This information along with motif identification has led to a new product function designation. In addition, this coding sequence has 100% amino acid identity with DsbI from C. jejuni 81-176 (CJJ81-176_0044). Characterisation paper within Campylobacter jejuni has led to being removed from product function. Functional classification -Synthesis and modification of macromolecules - Protein translation and modification; PMID:15632440; disulphide bond formation protein 23380 dsbI 904354 dsbI Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 disulphide bond formation protein YP_002343489.1 21854 R 192222 CDS YP_002343490.1 218561711 904356 complement(23392..23559) 1 NC_002163.1 Original (2000) note: Cj0018c, small hydrophobic protein, len: 55 aa; similar to TR:E1314390 (EMBL:AL031184) small hydrophobic protein SC2A11.18 from Streptomyces coelicolor (55 aa), fasta scores; opt: 72 z-score: 141.4 E(): 1.3, 32.7% identity in 49 aa overlap. 49.1% identity to HP0594 hypothetical protein; Updated (2006) note: Gram negative bacterial cells have disulfide bond formation occuring in the oxidative environment of the periplasm and are catalysed by Dsb (disulfide bond) proteins found in the periplasm and in the inner membrance. Supporting paper (PMID:15632440) speculates Dba has a supportive role as dba is co-transcribed with dsbI. This information has led to a new product function designation. Dba has 100% amino acid identity with Dba from 81-176 (CJJ81176_0045). Characterisation paper within Campylobacter jejuni has led to being removed from product function. Functional classification - Synthesis and modification of macromolecules - Protein translation and modification; PMID:15632440; disulphide bond formation protein 23559 dba 904356 dba Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 disulphide bond formation protein YP_002343490.1 23392 R 192222 CDS YP_002343491.1 218561712 904357 complement(23665..25443) 1 NC_002163.1 Original (2000) note: Cj0019c, probable MCP-domain signal transduction protein, len: 592 aa; similar to other proteins containing the MCP domain e.g. HLYB_VIBCH hemolysin secretion protein precursor (548 aa), fasta scores; opt: 418 z-score: 492.5 E(): 3.5e-20, 22.7% identity in 565 aa overlap, and AER_ECOLI aerotaxis receptor (506 aa), fasta scores; opt: 299 z-score: 391.2 E(): 1.6e-14, 25.5% identity in 357 aa overlap. 27.5% identity to HP0103. Contains N-terminal signal sequence and transmembrane anchor around aa 250. Also contains Pfam match to entry PF00015 MCPsignal, Methyl-accepting chemotaxis protein (MCP) signaling domain, score 104.90,E-value 1.7e-28; Updated (2006) note: Pfam domain PF00672 HAMP domain identified within CDS. Two probable transmembrace helices identified by TMHMM2.0. Further support given to product function. No specific characterisation with acceptable identity scores has yet been carried out. Thus, kept within product function. Functional classification - Signal transduction; MCP-domain signal transduction protein 25443 904357 Cj0019c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MCP-domain signal transduction protein YP_002343491.1 23665 R 192222 CDS YP_002343492.1 218561713 904360 complement(25433..26347) 1 NC_002163.1 Original (2000) note: Cj0020c, probable cytochrome C551 peroxidase, len: 304 aa; similar to CCPR_PSEAE cytochrome C551 peroxidase precursor (EC 1.11.1.5) (346 aa), fasta scores; opt: 775 z-score: 1167.7 E(): 0, 42.3% identity in 298 aa overlap. No Hp ortholog. Contains 2x PS00190 Cytochrome c family heme-binding site signature and probable N-terminal signal sequence; Updated (2006) note: Characterisation has been carried out within Pseudomonas aeruginosa with acceptable identity score. Appropriate motifs also identified. not added to product function. Functional classification - Cell processes - Detoxification; PMID:7781769, PMID:8591033, PMID:1657179; cytochrome C551 peroxidase 26347 904360 Cj0020c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytochrome C551 peroxidase YP_002343492.1 25433 R 192222 CDS YP_002343493.1 218561714 904361 complement(26411..27289) 1 NC_002163.1 Original (2000) note: Cj0021c, unknown, len: 292 aa; similar to hypothetical proteins e.g. TR:O06724 (EMBL:Z99109) B. subtilis yisK (301 aa), fasta scores; opt: 665 z-score: 1018.0 E(): 0, 43.1% identity in 255 aa overlap, and to C-terminal half of HPCE_ECOLI 2-hydroxyhepta-2,4-diene-1,7-dioate isomeraase/5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (405 aa), fasta scores; opt: 328 z-score: 381.2 E(): 5.6e-14, 31.2% identity in 199 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF01557 Fumarylacetoacetate (FAA) hydrolase family identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity score has been carried out yet. Thus, kept within product function. Functional classification - Misc; fumarylacetoacetate (FAA) hydrolase family protein 27289 904361 Cj0021c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 fumarylacetoacetate (FAA) hydrolase family protein YP_002343493.1 26411 R 192222 CDS YP_002343494.1 218561715 904362 complement(27402..28304) 1 NC_002163.1 Original (2000) note: Cj0022c, possible ribosomal pseudouridine synthase, len: 300 aa; similar to e.g. RLUD_ECOLI ribosomal large subunit pseudouridine synthase D (EC 4.2.1.70) (326 aa), fasta scores; opt: 344 z-score: 412.1 E(): 1.2e-15, 29.6% identity in 243 aa overlap. 41.1% identity to HP0347. Contains PS01129 Hypothetical yabO/yceC/sfhB family signature and Pfam match to entry PF00849 YABO, Hypothetical yabO/yceC/sfhB family, score 182.90, E-value 5e-51. Also similar to Cj1280c (31.0% identity) and Cj0708 (28.0% identity); Updated (2006) note: Characterisation has been carried out within Escherichia coli, however, identity score was marginal. Pfam domain PF00849 RNA pseudouridylate synthase was identified within CDS. This Pfam motif has been updated from the previous designation. Further support given to product function. kept within product function. Functional classification -Synthesis and modification of macromolecules - Ribosome maturation and modification; PMID:11453071, PMID:11087118, PMID:9814761,PMID:14501142; ribosomal pseudouridine synthase 28304 904362 Cj0022c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribosomal pseudouridine synthase YP_002343494.1 27402 R 192222 CDS YP_002343495.1 218561716 904425 28382..29710 1 NC_002163.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 29710 purB 904425 purB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 adenylosuccinate lyase YP_002343495.1 28382 D 192222 CDS YP_002343496.1 218561717 904363 29726..32095 1 NC_002163.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 32095 nrdA 904363 nrdA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribonucleotide-diphosphate reductase subunit alpha YP_002343496.1 29726 D 192222 CDS YP_002343497.1 218561718 904364 complement(32134..33519) 1 NC_002163.1 Original (2000) note: Cj0025c, probable transmembrane symporter (possibly glutamate), len: 461 aa; similar to many e.g. YB54_HAEIN hypothetical symporter HI1154 (440 aa), fasta scores; opt: 650 z-score: 890.6 E(): 0, 33.7% identity in 454 aa overlap, and TR:Q46202 (EMBL:X86516) Clostridium perfringens gluT-R gene (fragment) (132 aa), fasta scores; opt: 406 z-score: 569.0 E(): 1.9e-24, 49.6% identity in 119 aa overlap. No Hp match. Contains Pfam match to entry PF00375 SDF,Sodium:dicarboxylate symporter family, score 142.20,E-value 9.4e-39; Updated (2006) note: Pfam domain PF00375 Sodium:dicarboxylate symporter family identified within CDS. Eleven probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity score has been carried out yet. Thus, kept within product function. Functional classification - Transport/binding proteins - Other; sodium:dicarboxylate family transmembrane symporter 33519 904364 Cj0025c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sodium:dicarboxylate family transmembrane symporter YP_002343497.1 32134 R 192222 CDS YP_002343498.1 218561719 904365 complement(33639..34262) 1 NC_002163.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase 34262 thyX 904365 thyX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 FAD-dependent thymidylate synthase YP_002343498.1 33639 R 192222 CDS YP_002343499.1 218561720 904367 34382..36013 1 NC_002163.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 36013 pyrG 904367 pyrG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CTP synthetase YP_002343499.1 34382 D 192222 CDS YP_002343500.1 218561721 904450 36000..37571 1 NC_002163.1 Original (2000) note: Cj0028, recJ, probable single-stranded-DNA-specific exonuclease, len: 523 aa; similar to e.g. RECJ_ECOLI single-stranded-DNA-specific exonuclease (EC 3.1.-.-) (577 aa), fasta scores; opt: 385 z-score: 861.6 E(): 0, 29.8% identity in 526 aa overlap. 39.0% identity to HP0348; Updated (2006) note: Pfam domain HMMPfam PF01368 DHH family and HMMPfam PF02272 DHHA1 domain were identified within CDS. Further support given to product function. Characterised within Escherichia coli, however,marginal identity score was obtained. kept within product function. Functional classification - Synthesis and modification of macromolecules - DNA replication,restriction/modification, recombination and repair; PMID:2649886; single-stranded-DNA-specific exonuclease 37571 recJ 904450 recJ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 single-stranded-DNA-specific exonuclease YP_002343500.1 36000 D 192222 CDS YP_002343501.1 218561722 904872 37667..38662 1 NC_002163.1 Original (2000) note: Cj0029, ansA, probable cytoplasmic L-asparaginase, len: 331 aa; similar to many e.g. ASG2_ECOLI L-asparaginase II precursor (EC 3.5.1.1) (348 aa), fasta scores; opt: 1044 z-score: 1510.6 E(): 0,52.0% identity in 327 aa overlap, but with no signal sequence. 45.8% identity to HP0723. Contains PS00144 and PS00917 Asparaginase/glutaminase active site signatures 1 and 2 and Pfam match to entry PF00710 Asparaginase,Asparaginase, score 449.90, E-value 2.2e-131; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Thus, not added to product function. Functional classification - Degradation - Amino acids; PMID:2407723, PMID:1287659, PMID:8706862; cytoplasmic L-asparaginase 38662 ansA 904872 ansA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytoplasmic L-asparaginase YP_002343501.1 37667 D 192222 CDS YP_002343502.1 218561723 904369 44966..46363 1 NC_002163.1 Original (2000) note: Cj0030, unknown, len: 465 aa. No Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 46363 904369 Cj0030 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343502.1 44966 D 192222 CDS YP_002343503.1 218561724 904370 join(46424..49000,49002..50156) 1 NC_002163.1 Original (2000) note: Cj0031, probable DNA restriction/modification enzyme, N-terminal half, len: 867 aa; similar to N-terminus of T257_ECOLI type IIS restriction enzyme Eco57I (which contains an adenine-specific methyltransferase activity) (997 aa),fasta scores; opt: 126 z-score: 218.0 E(): 6.9e-05, 24.0% identity in 516 aa overlap. 40.9% identity to N-terminus of HP1517. Some similarity to N-terminus of Cj0690c (24.8% identity in 858 aa overlap). Contains PS00092 N-6 Adenine-specific DNA methylases signature. Note that there is a polymorphic poly-G tract at the C-terminus of this ORF with 8, 9, or 10 bases. G10 (the most common in our shotgun) causes a termination here, G9 causes a termination 6 aa earlier. G8 allows translation to continue into Cj0032; Original (2000) note: Cj0032, probable DNA restriction/modification enzyme, C-terminal half, len: 867 aa; similar to C-terminus of MTB3_BACAR modification methylase BanIII (580 aa), fasta scores; opt: 132 z-score: 220.8 E(): 4.9e-05, 24.6% identity in 402 aa overlap. 47.4% identity to C-terminus of HP1517. Note that there is a polymorphic poly-G tract at the N-terminus of this ORF with 8, 9, or 10 bases. G10 (the most common in our shotgun) or G9 will not allow translation into this ORF,G8 allows translation to continue from Cj0031. Alternative downstram start at 49059; Updated (2006) note: Coding sequences have been merged to reflect the complete amino acid sequence for this gene regardless of phase. Previous annotation gave N-terminal and C-terminal portions as seperate CDS. Merging of these CDSs has lead to loss of the downstream CDS. Functional classification - Synthesis and modification of macromolecules - DNA replication,restriction/modification, recombination and repair; type IIS restriction/modification enzyme 50156 904370 Cj0031 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 type IIS restriction/modification enzyme YP_002343503.1 46424 D 192222 CDS YP_002343504.1 218561725 904331 50156..51937 1 NC_002163.1 Original (2000) note: Cj0033, probable integral membrane protein, len: 593 aa; contains 6 possible transmembrane domains in C-terminal half. No Hp match. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 51937 904331 Cj0033 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343504.1 50156 D 192222 CDS YP_002343505.1 218561726 904372 complement(51967..52668) 1 NC_002163.1 Original (2000) note: Cj0034c, probable periplasmic protein, len: 233 aa; similar to e.g. TR:O50817 (EMBL:AE000788) Borrelia burgdorferi conserved hypothetical protein BBK13 (238 aa), fasta scores; opt: 306 z-score: 257.5 E(): 4.4e-07, 28.1% identity in 231 aa overlap. No Hp match. Contains possible N-terminal signal sequence. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 52668 904372 Cj0034c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343505.1 51967 R 192222 CDS YP_002343506.1 218561727 904517 complement(52665..53867) 1 NC_002163.1 Original (2000) note: Cj0035c, possible efflux protein, len: 400 aa; similar to many members of the bcr/cmlA subfamily of the major facilitator family e.g. BCR_ECOLI bicyclomycin resistance protein (396 aa), fasta scores; opt: 717 z-score: 1046.3 E(): 0, 28.1% identity in 398 aa overlap. No Hp ortholog. Contains 12 possible transmembrane domains. Also similar to Cj1375 (25.5% identity in 373 aa overlap); Updated (2006) note: Pfam domain PF07690 Major Facilitator Superfamily was identified within CDS. Further support given to product function. Some characterisation work within different bacteria, however, identity scores were marginal. Thus, kept within product function. Functional classification - Antibiotic resistance; PMID:2694948, PMID:8486276; efflux protein 53867 904517 Cj0035c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 efflux protein YP_002343506.1 52665 R 192222 CDS YP_002343507.1 218561728 904813 53970..55319 1 NC_002163.1 Original (2000) note: Cj0036, unknown, len: 449 aa; 37.8% identity to HP1143 hypothetical protein. Functional classification - Conserved hypothetical proteins; hypothetical protein 55319 904813 Cj0036 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343507.1 53970 D 192222 CDS YP_002343508.1 218561729 904547 complement(55343..56386) 1 NC_002163.1 Original (2000) note: Cj0037c, possible cytochrome C, len: 347 aa; weak simlarity to e.g. TR:O69780 (EMBL:U76906) di-heme cytochrome c (fixP) from Rhizobium etli (287 aa), fasta scores; opt: 97 z-score: 205.7 E(): 0.00034, 27.2% identity in 151 aa overlap. No Hp match. Contains 2x PS00190 Cytochrome c family heme-binding site signature and Pfam match to entry PF00034 cytochrome_c,Cytochrome c, score 5.90, E-value 0.11; Updated (2006) note: No specific characterisation with acceptable identity scores has been carried out yet. Thus, kept within product function. Functional classification - Energy metabolism - Respiration -Electron transport; cytochrome C 56386 904547 Cj0037c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytochrome C YP_002343508.1 55343 R 192222 CDS YP_002343509.1 218561730 904373 complement(56564..57211) 1 NC_002163.1 Original (2000) note: Cj0038c, possible membrane protein, len: 215 aa; no HP match. Contains two possible transmembrane domains at the N-terminus; Updated (2006) note: Pfam domain PF01743 Poly A polymerase family identified within CDS by carrying out own Pfam search. This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase,which adds the poly(A) tail to mRNA (EC:2.7.7.19). This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA (EC:2.7.7.25). Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet. Thus, kept within product function. Functional classification - Synthesis and modification of macromolecules - DNA replication,restriction/modification, recombination and repair; poly(A) polymerase family protein 57211 904373 Cj0038c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 poly(A) polymerase family protein YP_002343509.1 56564 R 192222 CDS YP_002343510.1 218561731 904374 complement(57211..59019) 1 NC_002163.1 Original (2000) note: Cj0039c, typA, GTP-binding protein typA homolog, len: 602 aa; similar to TYPA_ECOLI GTP-binding protein typA/bipA (591 aa), fasta scores; opt: 2145 z-score: 2659.1 E(): 0, 54.2% identity in 592 aa overlap, and to many EF-G proteins e.g. EFG_AGRTU elongation factor G (EF-G) (699 aa), fasta scores; opt: 344 z-score: 797.3 E(): 0, 26.2% identity in 715 aa overlap. 77.3% identity to HP0480. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00301 GTP-binding elongation factors signature and Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family (contains ATP/GTP binding P-loop), score 282.90, E-value 4e-81; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Thus, not added to product function. Homolog designation kept within product function. Functional classification - Synthesis and modification of macromolecules - Protein translation and modification; PMID:7783627, PMID:9642082, PMID:14560797; GTP-binding protein TypA 59019 typA 904374 typA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GTP-binding protein TypA YP_002343510.1 57211 R 192222 CDS YP_002343511.1 218561732 904375 59154..59477 1 NC_002163.1 Original (2000) note: Cj0040, unknown, len: 107 aa; no Hp match; Updated (2006) note: Literature search identified paper giving clues to product function. Functional classification - Unknown; PMID:14985343; hypothetical protein 59477 904375 Cj0040 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343511.1 59154 D 192222 CDS YP_002343512.1 218561733 904378 59493..61289 1 NC_002163.1 Original (2000) note: Cj0041, unknown, len: 598 aa; 25.2% identity to HP0906, but shorter at N-term; Updated (2006) note: Literature search identified papers linking product function to be involved in motility and invasion. Unpublished observation by N.Kamal & C. Penn have predicted this CDS to be fliK. Literature search identified work carried out in Campylobacter jejuni,Helicobacter pylori and Escherichia coli. Product function modified to more specific family member. was kept in product function as not fully characterised. Functional classification - Surface structures; PMID:12379703, PMID:14985343, PMID:15812042,PMID:11895937, PMID:16077121, PMID:15276839; flagellar hook-length control protein 61289 fliK 904378 fliK Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar hook-length control protein YP_002343512.1 59493 D 192222 CDS YP_002343513.1 218561734 904379 61343..62227 1 NC_002163.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; flagellar basal body rod modification protein 62227 flgD 904379 flgD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar basal body rod modification protein YP_002343513.1 61343 D 192222 CDS YP_002343514.1 218561735 906016 62231..63868 1 NC_002163.1 Original (2000) note: Cj0043, flgE, probable flagellar hook protein, len: 545 aa; similar to e.g. FLGE_BORBU flagellar hook protein flgE (442 aa), fasta scores; opt: 350 z-score: 665.8 E(): 7.9e-30, 27.5% identity in 553 aa overlap. 24.5% identity to HP0908. Contains PS00588 Flagella basal body rod proteins signature and Pfam match to entry PF00460 flg_bb_rod,Flagella basal body rod proteins, score 37.00, E-value 6.7e-08; Updated (2006) note: Characterised within Borrilia burgdorferi and also some work within Campylobacter jejuni. Identity scores were marginal. Appropriate motifs were present and alignments covered full length of sequence. Thus, not added to product function. Functional classification - Surface structures; PMID:9658019, PMID:9244248, PMID:9079915; flagellar hook protein 63868 flgE 906016 flgE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar hook protein YP_002343514.1 62231 D 192222 CDS YP_002343515.1 218561736 904380 complement(63872..65743) 1 NC_002163.1 Original (2000) note: Cj0044c, unknown, len: 623 aa; no Hp ortholog, Also similar to Cj0800c (28.5% identity in 625 aa overlap). Preceeded by a C(9-11) polymorphic region; C11 would allow the translation of Cj0045c to extend by another 15aa, overlapping the start of this CDS; C9 and C10 (consensus) have no effect; Updated (2006) note: Literature search identified paper giving further clues to product function. Functional classification - Conserved hypothetical proteins; PMID:14985343; hypothetical protein 65743 904380 Cj0044c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343515.1 63872 R 192222 CDS YP_002343516.1 218561737 904381 complement(65744..66466) 1 NC_002163.1 Original (2000) note: Cj0045c, possible iron-binding protein, len: 240 aa; weak similarity to members of the eukaryotic iron-binding hemerythrin family,e.g. HEMT_LINUN hemerythrin alpha chain (117 aa), fasta scores; opt: 105 z-score: 137.1 E(): 2.5, 23.8% identity in 122 aa overlap. Note that all of the iron-binding residues are conserved. No Hp match, similar to Cj0072c (pseudogene), Cj0241c (30.9% identity in 123 aa overlap) and Cj1224 (27.7% identity in 202 aa overlap). Contains a C(9-11) polymorphic region at the N-terminus; C11 would allow the translation of this CDS to extend by another 15aa, overlapping the start of Cj0044c; C9 and C10 (consensus) have little effect; Updated (2006) note: Pfam domain PF01814 Hemerythrin HHE cation binding domain identified within CDS. No specific characterisation with acceptable identity score has been carried out yet. Thus, kept within product function. Literature search identified paper giving further clues to product function. Functional classification - Transport/binding proteins - Cations; PMID:14985343; iron-binding protein 66466 904381 Cj0045c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 iron-binding protein YP_002343516.1 65744 R 192222 CDS YP_002343517.1 218561738 904383 complement(68532..69548) 1 NC_002163.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 69548 mnmA 904383 mnmA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tRNA-specific 2-thiouridylase MnmA YP_002343517.1 68532 R 192222 CDS YP_002343518.1 218561739 904384 complement(69548..70153) 1 NC_002163.1 Original (2000) note: Cj0054c, unknown, len: 201 aa; similar to hypothetical proteins e.g. TR:Q46063 (EMBL:X81379) Corynebacterium glutamicum hypothetucal protein (211 aa), fasta scores; opt: 426 z-score: 696.2 E(): 1.6e-31, 44.2% identity in 156 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03641 possible lysine decarboxylase family identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity score has been carried out yet. Thus, kept within product function. Functional classification -Misc; lysine decarboxylase family protein 70153 904384 Cj0054c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lysine decarboxylase family protein YP_002343518.1 69548 R 192222 CDS YP_002343519.1 218561740 904386 complement(70274..71098) 1 NC_002163.1 Original (2000) note: Cj0055c, unknown, len: 274 aa; no Hp match, similar in C-terminus to Cj0122 (46.6% identity in 148 aa overlap); Updated (2006) note: Contains Prosite match PS01164 COPPER_AMINE_OXID, Copper amine oxidase. Amine oxidases are enzymes that catalyze the oxidation of different biogenic amines e.g. neurotransmitters. Copper-containing amine oxidases are found in bacteria. This particular form binds one copper ion per subunit as well as a 2,4,5-trihydroxyphenylalanine quinone (or topaquinone) (TPQ) cofactor (PMID:8591028). Functional classification -Unknown; PMID:8591028; hypothetical protein 71098 904386 Cj0055c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343519.1 70274 R 192222 CDS YP_002343520.1 218561741 904387 complement(71155..71571) 1 NC_002163.1 Original (2000) note: Cj0056c, unknown, len: 138 aa. No Hp match; Updated (2006) note: Literature search identified paper giving clues to product function. Functional classification - Unknown; PMID:14702320; hypothetical protein 71571 904387 Cj0056c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343520.1 71155 R 192222 CDS YP_002343521.1 218561742 904388 72005..72859 1 NC_002163.1 Original (2000) note: Cj0057, possible periplasmic protein, len: 284 aa; no Hp match. Contains possible N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 72859 904388 Cj0057 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343521.1 72005 D 192222 CDS YP_002343522.1 218561743 904390 72844..73443 1 NC_002163.1 Original (2000) note: Cj0058, possible periplasmic protein, len: 199 aa; no Hp match. Contains possible N-terminal signal sequence; Updated (2006) note: Pfam domain PF03412 Peptidase C39 family identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation with acceptable identity scores carried out yet. Thus, kept within product function. Functional classification - Degradation of macromolecules - Proteins, peptides and glycopeptides; peptidase C39 family protein 73443 904390 Cj0058 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptidase C39 family protein YP_002343522.1 72844 D 192222 CDS YP_002343523.1 218561744 904391 complement(73492..74334) 1 NC_002163.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliY 74334 fliY 904391 fliY Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar motor switch protein FliY YP_002343523.1 73492 R 192222 CDS YP_002343524.1 218561745 904392 complement(74331..75410) 1 NC_002163.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 75410 fliM 904392 fliM Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar motor switch protein FliM YP_002343524.1 74331 R 192222 CDS YP_002343525.1 218561746 904393 complement(75410..76126) 1 NC_002163.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 76126 fliA 904393 fliA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar biosynthesis sigma factor YP_002343525.1 75410 R 192222 CDS YP_002343526.1 218561747 904394 complement(76083..76439) 1 NC_002163.1 Original (2000) note: Cj0062c, probable integral membrane protein, len: 118 aa; no Hp match. Contains two possible transmembrane domains. Functional classification - Cell envelope - Membranes, lipoproteins and porins; integral membrane protein 76439 904394 Cj0062c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343526.1 76083 R 192222 CDS YP_002343527.1 218561748 904395 complement(76458..77324) 1 NC_002163.1 Original (2000) note: Cj0063c, probable ATP-binding protein, len: 288 aa; similar to hypothetical proteins in other flagellar operons e.g. YLXH_BACSU hypothetical 33.2 kd protein in flhF-cheB intergenic region (298 aa), fasta scores; opt: 390 z-score: 493.5 E(): 3.1e-20, 29.0% identity in 293 aa overlap, and to cell division proteins e.g. MIND_BACSU septum site-determining protein minD (268 aa), fasta scores; opt: 323 z-score: 417.6 E(): 5.3e-16,32.9% identity in 249 aa overlap. 45.7% identity to HP1034. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry PF00991 ParA, ParA family ATPase, score 34.80, E-value 1.3e-06; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. Thus, kept within product function. Functional classification - Cell envelope - Surface structures; ATP-binding protein 77324 904395 Cj0063c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP-binding protein YP_002343527.1 76458 R 192222 CDS YP_002343528.1 218561749 904464 complement(77317..78771) 1 NC_002163.1 positive regulator of class III flagellar genes; flagellar biosynthesis regulator FlhF 78771 flhF 904464 flhF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar biosynthesis regulator FlhF YP_002343528.1 77317 R 192222 CDS YP_002343529.1 218561750 904396 complement(78781..79254) 1 NC_002163.1 Original (2000) note: Cj0065c, folK, possible 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, len: 157 aa, similar to e.g. HPPK_BACSU 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (167 aa), fasta scores; opt: 194 z-score: 370.0 E(): 2.4e-13, 28.7% identity in 129 aa overlap. 35.6% identity to HP1036. Contains Pfam match to entry PF01288 HPPK,7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK), score 4.10, E-value 1.1e-06; Updated (2006) note: Characterised within Bacillus subtilis and Escherichia coli, however, identity scores were marginal. Thus, kept within product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Folic acid; PMID:1325970; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 79254 folK 904396 folK Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_002343529.1 78781 R 192222 CDS YP_002343530.1 218561751 904397 complement(79257..79736) 1 NC_002163.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 79736 aroQ 904397 aroQ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 3-dehydroquinate dehydratase YP_002343530.1 79257 R 192222 CDS YP_002343531.1 218561752 904398 79827..81056 1 NC_002163.1 Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline; chlorohydrolase 81056 904398 Cj0067 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 chlorohydrolase YP_002343531.1 79827 D 192222 CDS YP_002343532.1 218561753 905251 81044..81940 1 NC_002163.1 Original (2000) note: Cj0068, pspA, probable protease required for pilus-like appendage formation, len: 298 aa; almost identical to TR:P71127 (EMBL:U38524) pspA (298 aa) (99.0% identity in 298 aa overlap) and similar to the C-terminus of e.g. SPPA_ECOLI protease IV (618 aa),fasta scores; opt: 285 z-score: 266.8 E(): 1.3e-07, 24.7% identity in 251 aa overlap. 42.0% identity to HP1435; Updated (2006) note: Pfam domain PF01343 Peptidase family S49 identified within CDS. Product function based on direct submission with paper (PMID:8793884). not added to product function due to characterisation work within Campylobacter jejuni. Functional classification -Degradation of macromolecules - Surface structures; PMID:8793884, PMID:3522590; protease 81940 pspA 905251 pspA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 protease YP_002343532.1 81044 D 192222 CDS YP_002343533.1 218561754 905192 82019..83050 1 NC_002163.1 Original (2000) note: Cj0069, unknown, len: 343 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Literature search identified paper giving further clues to product function. Functional classification - Unknown; PMID:14702320; hypothetical protein 83050 905192 Cj0069 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343533.1 82019 D 192222 CDS YP_002343534.1 218561755 904429 complement(83047..83205) 1 NC_002163.1 Original (2000) note: Cj0070c, questionable CDS,len: 52 aa; no Hp match; Updated (2006) note: Similar to proteins in other bacteria. Functional classification - Unknown; hypothetical protein 83205 904429 Cj0070c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343534.1 83047 R 192222 CDS YP_002343535.1 218561756 904400 complement(84087..84743) 1 NC_002163.1 Original (2000) note: Cj0073c, unknown, len: 218 aa; similar to hypothetical proteins e.g. YKGG_ECOLI (282 aa), fasta scores; opt: 215 z-score: 231.0 E(): 1.3e-05,32.2% identity in 146 aa overlap. 41.8% identity to HP0137; Updated (2006) note: Pfam domain PF02589 Uncharacterized ACR, YkgG family COG1556 identified within CDS. Conserved added to product function. Literature search identified paper giving further clues to product function. Functional classification - Conserved hypothetical proteins; PMID:15773975; hypothetical protein 84743 904400 Cj0073c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343535.1 84087 R 192222 CDS YP_002343536.1 218561757 904401 complement(84736..86175) 1 NC_002163.1 Original (2000) note: Cj0074c, probable iron-sulfur protein, len: 479 aa; similar to hypothetical proteins e.g. YKGF_ECOLI (475 aa), fasta scores; opt: 1142 z-score: 1335.9 E(): 0, 38.3% identity in 462 aa overlap. 58.1% identity to HP0138. Contains 2x PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature and 2x Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains., scores 13.80, E-value 0.0095, and 12.30, E-value 0.026; Updated (2006) note: No specific characterisation with acceptable identity scores. Thus, kept within product function. Functional classification -Energy metabolism - Electron transport; PMID:15773975; iron-sulfur protein 86175 904401 Cj0074c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 iron-sulfur protein YP_002343536.1 84736 R 192222 CDS YP_002343537.1 218561758 904402 complement(86172..86912) 1 NC_002163.1 Original (2000) note: Cj0075c, possible oxidoreductase iron-sulfur subunit, len: 246 aa; similar to hypothetical proteins and to the C-terminus of e.g. TR:O53142 (EMBL:AJ000942) Methanobacterium thermoautotrophicum strain Marburg, Thiol:fumarate reductase subunit B (488 aa), fasta scores; opt: 217 z-score: 476.0 E(): 3e-1, 24.3% identity in 235 aa overlap. 60.7% identity to HP0139; Updated (2006) note: Pfam domain x2 PF02754 Cysteine-rich domain identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score. Thus, kept within product function. Functional classification - Energy metabolism - Electron transport; PMID:15773975; oxidoreductase iron-sulfur subunit 86912 904402 Cj0075c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 oxidoreductase iron-sulfur subunit YP_002343537.1 86172 R 192222 CDS YP_002343538.1 218561759 904403 complement(87036..88718) 1 NC_002163.1 Original (2000) note: Cj0076c, lctP, probable L-lactate permease, len: 560 aa; highly similar to many e.g. LLDP_ECOLI L-lactate permease (551 aa), fasta scores; opt: 1957 z-score: 2614.5 E(): 0, 54.0% identity in 556 aa overlap. 61.2% identity to HP0141 and 60.6% identity to HP0140; Updated (2006) note: Pfam domain PF02652 L-lactate permease identified within CDS. Thirteen probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. Thus, not added to product function. Functional classification - Transport/binding proteins -Carbohydrates, organic acids and alcohols; PMID:8407843, PMID:11283302, PMID:11785976; L-lactate permease 88718 lctP 904403 lctP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 L-lactate permease YP_002343538.1 87036 R 192222 CDS YP_002343539.1 218561760 904404 complement(88890..89459) 1 NC_002163.1 Original (2000) note: Cj0077c, cdtC, cytolethal distending toxin, len: 189 aa, identical to TR:Q46102 (EMBL:U51121) cdtC (189 aa). No Hp match. Contains N-terminal signal sequence; Updated (2006) note: Pfam domain PF03499 Cytolethal distending toxin C identified within CDS. Product modified to more specific family member due to motif match. Characterised within Campylobacter jejuni, so not added to product function. Functional classification -Pathogenicity; PMID:10688204, PMID:8675309, PMID:11083762; cytolethal distending toxin C 89459 cdtC 904404 cdtC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytolethal distending toxin C YP_002343539.1 88890 R 192222 CDS YP_002343540.1 218561761 904405 complement(89470..90267) 1 NC_002163.1 Original (2000) note: Cj0078c, cdtB, cytolethal distending toxin, len: 265 aa; identical toTR:Q46101 (EMBL:U51121) cdtB (265 aa) and similar to e.g. TR:Q47089 (EMBL:U03293) Escherichia coli cdtB (273 aa), fasta scores; opt: 946 z-score: 1533.6 E(): 0, 55.2% identity in 268 aa overlap. No Hp match. Contains N-terminal signal sequence; Updated (2006) note: Prosite domain PRO1388 CDTOXINB, Cytolethal distending toxin B signature identified within CDS. Product modified to more specific family member due to motif match. Characterised within Campylobacter jejuni, so not added to product function. Functional classification - Pathogenicity; PMID:10688204, PMID:8675309, PMID:11083762; cytolethal distending toxin B 90267 cdtB 904405 cdtB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytolethal distending toxin B YP_002343540.1 89470 R 192222 CDS YP_002343541.1 218561762 904406 complement(90264..91070) 1 NC_002163.1 Original (2000) note: Cj0079c, cdtA, cytolethal distending toxin, len: 268 aa; identical to TR:Q46100 (EMBL:U51121) cdtB (268 aa) and similar to e.g. TR:Q47088 (EMBL:U03293) Escherichia coli cdtA (237 aa), fasta scores; opt: 310 z-score: 408.0 E(): 1.8e-15, 32.7% identity in 159 aa overlap. No Hp match. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Pfam domain PF03498 Cytolethal distending toxin A identified within CDS. Product modified to more specific family member due to motif match. Characterised within Campylobacter jejuni, so not added to product function. Functional classification -Pathogenicity; PMID:10688204, PMID:8675309, PMID:11083762; cytolethal distending toxin A 91070 cdtA 904406 cdtA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytolethal distending toxin A YP_002343541.1 90264 R 192222 CDS YP_002343542.1 218561763 904407 91147..91416 1 NC_002163.1 Original (2000) note: Cj0080, possible membrane protein, len: 267 aa; no Hp match; Contains one possible transmembrane domain; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0; hypothetical protein 91416 904407 Cj0080 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343542.1 91147 D 192222 CDS YP_002343543.1 218561764 904408 91417..92979 1 NC_002163.1 Original (2000) note: Cj0081, cydA, probable cytochrome bd oxidase subunit I, len: 520 aa;similar to many e.g. APPC_ECOLI cytochrome bd-ii oxidase subunit I (EC 1.10.3.-) (514 aa), fasta scores; opt: 1412 z-score: 1888.2 E(): 0, 45.7% identity in 530 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF01654 Bacterial Cytochrome Ubiquinol Oxidase identified within CDS. Also,nine probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. Thus, not added to product function. Functional classification - Energy metabolism - Electron transport; PMID:8626304, PMID:9068659, PMID:9852001; cytochrome bd oxidase subunit I 92979 cydA 904408 cydA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytochrome bd oxidase subunit I YP_002343543.1 91417 D 192222 CDS YP_002343544.1 218561765 904409 92979..94103 1 NC_002163.1 Original (2000) note: Cj0082, cydB, probable cytochrome bd oxidase subunit II, len: 520 aa;similar to many e.g. CYDB_ECOLI cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-) (379 aa), fasta scores; opt: 466 z-score: 449.6 E(): 8.7e-18, 27.7% identity in 386 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02322 Cytochrome oxidase subunit II identified within CDS. Also, nine probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised within Escherichia coli with marginal identity score. not added to product function. Functional classification - Energy metabolism - Electron transport; PMID:8626304, PMID:9068659, PMID:9852001,PMID:15470119; cytochrome bd oxidase subunit II 94103 cydB 904409 cydB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytochrome bd oxidase subunit II YP_002343544.1 92979 D 192222 CDS YP_002343545.1 218561766 904410 complement(94297..94992) 1 NC_002163.1 Original (2000) note: Cj0085c, probable amino acid recemase, len: 231 aa; similar to members of the aspartate/glutamate racemases family e.g. YGEA_ECOLI (230 aa), fasta scores; opt: 667 z-score: 1155.6 E(): 0, 46.7% identity in 225 aa overlap, and RACD_STRTR aspartate racemase (243 aa), fasta scores; opt: 254 z-score: 230.9 E(): 1.3e-05, 25.4% identity in 232 aa overlap. No Hp match. Contains PS00924 Aspartate and glutamate racemases signature 2 andPfam match to entry PF01177 Asp_Glu_race,Aspartate / glutamate racemase, score 108.40, E-value 1.3e-28; Updated (2006) note: Pfam domain PF01177 Asp/Glu/Hydantoin racemase identified within CDS. No specific characterisation with acceptable identity score identified. Thus, kept within product function. Functional classification - Misc; amino acid recemase 94992 904410 Cj0085c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amino acid recemase YP_002343545.1 94297 R 192222 CDS YP_002343546.1 218561767 904411 complement(95108..95803) 1 NC_002163.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 95803 ung 904411 ung Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 uracil-DNA glycosylase YP_002343546.1 95108 R 192222 CDS YP_002343547.1 218561768 904412 96074..97480 1 NC_002163.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 97480 aspA 904412 aspA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aspartate ammonia-lyase YP_002343547.1 96074 D 192222 CDS YP_002343548.1 218561769 904413 97496..98833 1 NC_002163.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 98833 dcuA 904413 dcuA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 anaerobic C4-dicarboxylate transporter YP_002343548.1 97496 D 192222 CDS YP_002343549.1 218561770 904416 98941..100302 1 NC_002163.1 Original (2000) note: Cj0089, probable lipoprotein,len: 453 aa; 27.4% identity to HP0018. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification - Membranes, lipoproteins and porins; lipoprotein 100302 904416 Cj0089 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002343549.1 98941 D 192222 CDS YP_002343550.1 218561771 904418 100312..100680 1 NC_002163.1 Original (2000) note: Cj0090, probable lipoprotein,len: 122 aa; no Hp match. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification - Membranes, lipoproteins and porins; lipoprotein 100680 904418 Cj0090 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002343550.1 100312 D 192222 CDS YP_002343551.1 218561772 904419 100704..101327 1 NC_002163.1 Original (2000) note: Cj0091, probable lipoprotein,len: 207 aa; 33.5% identity to HP1457. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification - Membranes, lipoproteins and porins; lipoprotein 101327 904419 Cj0091 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002343551.1 100704 D 192222 CDS YP_002343552.1 218561773 904420 101410..102747 1 NC_002163.1 Original (2000) note: Cj0092, probable periplasmic protein, len: 445 aa; no Hp match. Contains probable N-terminal signal sequence and PS00017 ATP/GTP-binding site motif A (P-loop). Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 102747 904420 Cj0092 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343552.1 101410 D 192222 CDS YP_002343553.1 218561774 904421 102757..103959 1 NC_002163.1 Original (2000) note: Cj0093, probable periplasmic protein, len: 400 aa; no Hp match. Contains probable N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 103959 904421 Cj0093 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343553.1 102757 D 192222 CDS YP_002343554.1 218561775 904422 104118..104426 1 NC_002163.1 Original (2000) note: Cj0094, rplU, 50S ribosomal protein L21, len: 102 aa; similar to many e.g. RL21_ECOLI 50S ribosomal protein L21 (103 aa), fasta scores; opt: 268 z-score: 457.7 E(): 3.1e-18, 40.8% identity in 103 aa overlap. 58.8% identity to HP0296. Contains PS01169 Ribosomal protein L21 signature and Pfam match to entry PF00829 Ribosomal_L21p, Ribosomal prokaryotic L21 protein,score 152.80, E-value 5.7e-42; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Thus, not added to product function. Functional classification - Ribosomal protein synthesis and modification; PMID:378941, 8312607; 50S ribosomal protein L21 104426 rplU 904422 rplU Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L21 YP_002343554.1 104118 D 192222 CDS YP_002343555.1 218561776 904423 104437..104691 1 NC_002163.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 104691 rpmA 904423 rpmA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L27 YP_002343555.1 104437 D 192222 CDS YP_002343556.1 218561777 905891 104798..105850 1 NC_002163.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 105850 obgE 905891 obgE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GTPase ObgE YP_002343556.1 104798 D 192222 CDS YP_002343557.1 218561778 904426 105955..106710 1 NC_002163.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 106710 proB 904426 proB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 gamma-glutamyl kinase YP_002343557.1 105955 D 192222 CDS YP_002343558.1 218561779 904427 106784..107701 1 NC_002163.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 107701 fmt 904427 fmt Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methionyl-tRNA formyltransferase YP_002343558.1 106784 D 192222 CDS YP_002343559.1 218561780 904428 107664..108317 1 NC_002163.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 108317 birA 904428 birA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 biotin--protein ligase YP_002343559.1 107664 D 192222 CDS YP_002343560.1 218561781 904430 108314..109099 1 NC_002163.1 Original (2000) note: Cj0100, parA family protein, len: 261 aa; similar to members of the parA family e.g. SOJ_BACSU soj protein (253 aa) fasta scores; opt: 762 z-score: 1251.6 E(): 0, 46.3% identity in 259 aa overlap. 61.1% identity to HP1139. Contains Pfam match to entry PF00991 ParA, ParA family ATPase, score 118.40,E-value 1.3e-31; Updated (2006) note: Pfam domain PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain identified within CDS. This family consists of cobyrinic acid a,c-diamide synthases family protein. Some characterisation work within Bacillus subtilis with acceptable identity score. not added to product function. Functional classification - Cell division; PMID:8071208; parA family protein 109099 904430 Cj0100 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 parA family protein YP_002343560.1 108314 D 192222 CDS YP_002343561.1 218561782 904366 109105..109941 1 NC_002163.1 Original (2000) note: Cj0101, parB family protein, len: 278 aa; similar to members of the parB family e.g.SP0J_BACSU stage 0 sporulation protein J (282 aa), fasta scores; opt: 563 z-score: 842.8 E(): 0, 36.1% identity in 288 aa overlap. 41.7% identity to HP1138 plasmid replication-partition related protein. Contains helix-turn-helix motif (Score 1486, +4.25 SD); Updated (2006) note: Pfam domain PF02195 ParB-like nuclease domain identified within CDS. Some characterisation within Bacillus subtilis with acceptable identity score. not added to product function. Functional classification - Cell division; PMID:1900505, PMID:8071208; parB family protein 109941 904366 Cj0101 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 parB family protein YP_002343561.1 109105 D 192222 CDS YP_002343562.1 218561783 904431 110002..110427 1 NC_002163.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B' is part of the membrane proton channel.; F0F1 ATP synthase subunit B' 110427 atpF' 904431 atpF' Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 F0F1 ATP synthase subunit B' YP_002343562.1 110002 D 192222 CDS YP_002343563.1 218561784 904432 110438..110950 1 NC_002163.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 110950 atpF 904432 atpF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 F0F1 ATP synthase subunit B YP_002343563.1 110438 D 192222 CDS YP_002343564.1 218561785 904434 110953..111474 1 NC_002163.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 111474 atpH 904434 atpH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 F0F1 ATP synthase subunit delta YP_002343564.1 110953 D 192222 CDS YP_002343565.1 218561786 904435 111488..112993 1 NC_002163.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 112993 atpA 904435 atpA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 F0F1 ATP synthase subunit alpha YP_002343565.1 111488 D 192222 CDS YP_002343566.1 218561787 904436 113002..113886 1 NC_002163.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 113886 atpG 904436 atpG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 F0F1 ATP synthase subunit gamma YP_002343566.1 113002 D 192222 CDS YP_002343567.1 218561788 904437 113912..115309 1 NC_002163.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 115309 atpD 904437 atpD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 F0F1 ATP synthase subunit beta YP_002343567.1 113912 D 192222 CDS YP_002343568.1 218561789 904438 115313..115702 1 NC_002163.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 115702 atpC 904438 atpC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 F0F1 ATP synthase subunit epsilon YP_002343568.1 115313 D 192222 CDS YP_002343569.1 218561790 904439 115702..116256 1 NC_002163.1 Original (2000) note: Cj0109, exbB3, probable exbB/tolQ family transport protein, len: 184 aa; similar to members of the exbB/tolQ family, e.g. EXBB_ECOLI biopolymer transport exbB protein (244 aa), fasta scores; opt: 208 z-score: 287.0 E(): 9.9e-09, 33.6% identity in 128 aa overlap, and TOLQ_ECOLI tolQ protein (230 aa),fasta scores; opt: 187 z-score: 280.1 E(): 2.4e-08, 48.4% identity in 62 aa overlap. 42.6% identity to HP1130. Also similar to Cj0179 (30.6% identity in 186 aa overlap) and Cj1628 (44.4% identity in 81 aa overlap); Updated (2006) note: Pfam domain PF01618,MotA/TolQ/ExbB proton channel family identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet. Thus, kept within product function. Functional classification - Transport/binding proteins - Other; PMID:8437515, PMID:9371459; MotA/TolQ/ExbB proton channel family protein 116256 exbB3 904439 exbB3 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MotA/TolQ/ExbB proton channel family protein YP_002343569.1 115702 D 192222 CDS YP_002343570.1 218561791 904440 116265..116654 1 NC_002163.1 Original (2000) note: Cj0110, exbD3, probable exbD/tolR family transport protein, len: 129 aa; similar to members of the exbD/tolR family, e.g. EXBD_ECOLI biopolymer transport exbD protein (141 aa), fasta scores; opt: 225 z-score: 240.1 E(): 4e-06, 31.1% identity in 132 aa overlap, and TOLR_ECOLI tolR protein (142 aa), fasta scores; opt: 191 z-score: 240.1 E(): 4.1e-06, 27.7% identity in 130 aa overlap. 46.8% identity to HP1129. Also similar to Cj0180 (34.1% identity in 126 aa overlap) and Cj1629 (26.4% identity in 121 aa overlap); Updated (2006) note: Pfam domain PF02472 Biopolymer transport protein ExbD/TolR identified within CDS. Further support given to product function. No specific characterisation with acceptable identity scores were identified. Thus, kept within product function. Functional classification - Transport/binding proteins -Other; PMID:9371459; exbD/tolR family transport protein 116654 exbD3 904440 exbD3 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 exbD/tolR family transport protein YP_002343570.1 116265 D 192222 CDS YP_002343571.1 218561792 904442 116657..117436 1 NC_002163.1 Original (2000) note: Cj0111, possible periplasmic protein, len: 259 aa; no Hp match. Contains possible N-terminal signal sequence; Updated (2006) note: Literature search identified paper (PMID:15231804) suggesting a number of differentially expressed genes (e.g. Cj0111) in microarray experiments may be co-trasncribed. Cj0111 seems to be iron induced and based on RT-PCR seems to be co-transcribed with Cj1658. Functional classification - Miscellaneous periplasmic proteins; PMID:15231804; periplasmic protein 117436 904442 Cj0111 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343571.1 116657 D 192222 CDS YP_002343572.1 218561793 904443 117446..118654 1 NC_002163.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 118654 tolB 904443 tolB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 translocation protein TolB YP_002343572.1 117446 D 192222 CDS YP_002343573.1 218561794 904444 118731..119228 1 NC_002163.1 Original (2000) note: Cj0113, pal, peptidoglycan associated lipoprotein (omp18), len: 165 aa; identical to TR:Q46123 (EMBL:X83374) precursor of peptidoglycan associated lipoprotein (165 aa), almost identical to TR:Q46099 omp18 (165 aa) (93.9% identity). Similar to e.g. PAL_ECOLI peptidoglycan-associated lipoprotein precursor (173 aa), fasta scores; opt: 322 z-score: 491.5 E(): 4e-20, 38.5% identity in 169 aa overlap. 42.2% identity (in 109 aa overlap) to HP1125. Contains N-terminal signal sequence with appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and Pfam match to entry PF00691 OmpA, OmpA family, score 100.60, E-value 3.2e-26; Updated (2006) note: Characterised within Campylobacter jejuni (PMID:8576327). not added to product function. Functional classification - Membranes,lipoproteins and porins; PMID:8576327; peptidoglycan associated lipoprotein 119228 pal 904444 pal Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptidoglycan associated lipoprotein YP_002343573.1 118731 D 192222 CDS YP_002343574.1 218561795 904445 119232..120179 1 NC_002163.1 Original (2000) note: Cj0114, possible periplasmic protein, len: 315 aa; similar to hypothetical protein YBGF_ECOLI hypothetical 28.2 kd protein in pal-lysT intergenic region (263 aa), fasta scores; opt: 144 z-score: 238.8 E(): 4.8e-06, 21.3% identity in 249 aa overlap. 28.6% identity to HP1124. Contains possible N-terminal signal sequence; Updated (2006) note: Prosite PS50005 TPR_REPEAT,Tetratricopeptide region identified within CDS. Supporting paper identifies protein as a glycoprotein. Functional classification - Miscellaneous periplasmic proteins; PMID:12186869; periplasmic protein 120179 904445 Cj0114 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343574.1 119232 D 192222 CDS YP_002343575.1 218561796 904446 120194..120763 1 NC_002163.1 Original (2000) note: Cj0115, slyD, probable peptidyl-prolyl cis-trans isomerase, len: 189 aa; similar to many of the FKBP-type e.g. SLYD_ECOLI FKBP-type peptidyl-prolyl cis-trans isomerase (196 aa), fasta scores; opt: 478 z-score: 296.9 E(): 2.8e-09, 38.5% identity in 200 aa overlap. 39.2% identity to HP1123; Updated (2006) note: Prosite PS50059 FKBP_PPIASE,Peptidylprolyl isomerase, FKBP-type domain identified within CDS. Product modified to more specific family member due to motif match. Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Protein translation and modification; PMID:9188461; FKBP-type peptidyl-prolyl cis-trans isomerase 120763 slyD 904446 slyD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 FKBP-type peptidyl-prolyl cis-trans isomerase YP_002343575.1 120194 D 192222 CDS YP_002343576.1 218561797 904447 120763..121683 1 NC_002163.1 Original (2000) note: Cj0116, fabD, probable malonyl CoA-acyl carrier protein transacylase, len: 306 aa; similar to many e.g. FABD_ECOLI malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) (308 aa), fasta scores; opt: 555 z-score: 655.2 E(): 3.1e-29, 36.1% identity in 296 aa overlap. 49.5% identity to HP0090. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain, score 58.10, E-value 1.9e-13; Updated (2006) note: Characterised within Escherichia coli with acceptable identity scores. Thus, not added to product function. Functional classification - Fatty acid biosynthesis; PMID:1339356, PMID:7768883, PMID:8759840; malonyl CoA-acyl carrier protein transacylase 121683 fabD 904447 fabD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 malonyl CoA-acyl carrier protein transacylase YP_002343576.1 120763 D 192222 CDS YP_002343577.1 218561798 904448 121680..122369 1 NC_002163.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 122369 pfs 904448 pfs Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_002343577.1 121680 D 192222 CDS YP_002343578.1 218561799 904449 122366..123121 1 NC_002163.1 Original (2000) note: Cj0118, unknown, len: 251 aa; similar to hypothetical proteins from many organisms e.g. YDAO_ECOLI (311 aa), fasta scores; opt: 447 z-score: 465.6 E(): 1.1e-18, 32.5% identity in 240 aa overlap. 49.4% identity to HP1182. Contains Pfam match to entry PF01171 UPF0021, Uncharacterized protein family UPF0021, score -88.80, E-value 9.9e-05; Updated (2006) note: Pfam domain PF01171 PP-loop family identified within CDS. No specific characterisation has been carried out. Thus, kept within product function. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 123121 904449 Cj0118 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343578.1 122366 D 192222 CDS YP_002343579.1 218561800 904451 123126..123647 1 NC_002163.1 Original (2000) note: Cj0119, unknown, len: 173 aa; similar to a hypothetical protein from B. subtilis TR:O32091 (EMBL:Z99120) YUEJ protein (183 aa), fasta scores; opt: 172 z-score: 282.5 E(): 1.8e-08, 29.5% identity in 166 aa overlap. No Hp match; Updated (2006) note: Motif match (IPR000868) identified link to hydrolase. Product modified to more specific family member based on motif match. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Misc; hydrolase 123647 904451 Cj0119 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hydrolase YP_002343579.1 123126 D 192222 CDS YP_002343580.1 218561801 904452 123647..124261 1 NC_002163.1 Original (2000) note: Cj0120, unknown, len: 204 aa; 41.7% identity to HP0951. Functional classification -Conserved hypothetical proteins; recombination protein RecO 124261 904452 Cj0120 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 recombination protein RecO YP_002343580.1 123647 D 192222 CDS YP_002343581.1 218561802 904453 124258..124665 1 NC_002163.1 Original (2000) note: Cj0121, unknown, len: 135 aa; similar to hypothetical proteins from many organisms e.g. YBEY_ECOLI (155 aa) fasta scores; opt: 218 z-score: 353.9 E(): 1.9e-12, 37.8% identity in 111 aa overlap. 59.8% identity to HP1160; Updated (2006) note: Pfam PF02130 Uncharacterized protein family UPF0054 was present within CDS. Conserved added to product function. Functional classification -Conserved hypothetical proteins; metalloprotease 124665 904453 Cj0121 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 metalloprotease YP_002343581.1 124258 D 192222 CDS YP_002343582.1 218561803 904454 124789..125478 1 NC_002163.1 Original (2000) note: Cj0122, unknown, len: 229 aa; no Hp match. Similar in C-terminus to Cj0055c (46.6% identity in 148 aa overlap), and in N-terminus to Cj0416 (88.2% identity in 34 aa overlap); Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 125478 904454 Cj0122 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343582.1 124789 D 192222 CDS YP_002343583.1 218561804 904455 complement(125503..126429) 1 NC_002163.1 Original (2000) note: Cj0123c, possible transcriptional regulator, len: 308 aa; similar to hypothetical proteins e.g. YACF_BACSU (333 aa), fasta scores; opt: 566 z-score: 916.8 E(): 0, 37.2% identity in 312 aa overlap, and to e.g. NIR3_RHOCA nitrogen regulation protein nifR3 (324 aa), fasta scores; opt: 517 z-score: 616.2 E(): 4.6e-27, 34.4% identity in 317 aa overlap. 49.5% identity to HP0727. Contains Pfam match to entry PF01207 UPF0034, Uncharacterized protein family UPF0034,score 260.90, E-value 1.7e-74; Updated (2006) note: Pfam domain PF01207 Dihydrouridine synthase (Dus) identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity scores carried out yet. Thus, kept within product function. Functional classification - Misc; tRNA-dihydrouridine synthase 126429 904455 Cj0123c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tRNA-dihydrouridine synthase YP_002343583.1 125503 R 192222 CDS YP_002343584.1 218561805 904457 complement(126426..127412) 1 NC_002163.1 Original (2000) note: Cj0124c, probable membrane protein, len: 328 aa; 21.1% identity to HP0948. Contains two possible transmembrane domains. Functional classification - Membranes, lipoproteins and porins; hypothetical protein 127412 904457 Cj0124c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343584.1 126426 R 192222 CDS YP_002343585.1 218561806 904459 complement(127402..127764) 1 NC_002163.1 Original (2000) note: Cj0125c, unknown, len: 120 aa; some similarity to e.g. DKSA_ECOLI dnaK suppressor protein (151 aa), fasta scores; opt: 186 z-score: 276.6 E(): 3.8e-08, 26.3% identity in 118 aa overlap. No Hp match. Contains PS01102 Prokaryotic dksA/traR C4-type zinc finger and Pfam match to entry PF01258 zf_dskA_traR,Prokaryotic dksA/traR C4-type zinc finger, score 39.20,E-value 9.7e-08; Updated (2006) note: No specific characterisation has been carried out yet. Functional classification -Conserved hypothetical proteins; hypothetical protein 127764 904459 Cj0125c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343585.1 127402 R 192222 CDS YP_002343586.1 218561807 904460 complement(127776..128237) 1 NC_002163.1 Original (2000) note: Cj0126c, unknown, len: 153 aa; similar to hypotheticals e.g. YBEA_ECOLI (155 aa),fasta scores; opt: 189 z-score: 288.6 E(): 8.1e-09, 28.1% identity in 153 aa overlap. 37.2% identity to HP0949; Updated (2006) note: Pfam PF02590 Uncharacterized ACR family was present within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 128237 904460 Cj0126c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343586.1 127776 R 192222 CDS YP_002343587.1 218561808 904461 complement(128227..129069) 1 NC_002163.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 129069 accD 904461 accD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetyl-CoA carboxylase subunit beta YP_002343587.1 128227 R 192222 CDS YP_002343588.1 218561809 904462 complement(129078..129800) 1 NC_002163.1 Original (2000) note: Cj0128c, unknown, len: 240 aa; some similarity to e.g. SUHB_ECOLI extragenic suppressor protein suhB (267 aa), fasta scores; opt: 168 z-score: 229.0 E(): 1.7e-05, 29.9% identity in 134 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF00459 Inositol monophosphatase family identified within CDS. Product modified to more specific family member due to motif match. Characterised within Escherichia coli, however,identity scores were not acceptable. Functional classification - Misc; PMID:10747806, PMID:8002619; inositol monophosphatase family protein 129800 904462 Cj0128c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 inositol monophosphatase family protein YP_002343588.1 129078 R 192222 CDS YP_002343589.1 218561810 904463 complement(129800..132019) 1 NC_002163.1 Original (2000) note: Cj0129c, probable outer membrane protein, len: 739 aa; similar to e.g. TR:O30912 (EMBL:AF021245) Neisseria meningitidis outer membrane protein omp85 (797 aa), fasta scores; opt: 643 z-score: 886.3 E(): 0, 25.3% identity in 782 aa overlap, and D152_HAEIN protective surface antigen d15 precursor (795 aa), fasta scores; opt: 523 z-score: 548.2 E(): 2.8e-23,24.3% identity in 807 aa overlap. 34.2% identity to HP0655. Contains N-terminbal signal sequence and Pfam match to entry PF01103 Bac_suface_Ag, Bacterial surface antigen, score 404.10, E-value 1.3e-117; Updated (2006) note: Pfam domains PF01103 Surface antigen and x5 PF07244 Surface antigen variable number repeat were identified within CDS. Further support given to product function. Literature search identified papers giving further clues to product function. Characterisation has been carried out within Escherichia coli, however,identity scores were marginal. Appropriate motifs were present. not added to product function. Functional classification - Membranes, lipoproteins and porins; PMID:11422558, PMID:16102012; outer membrane protein 132019 904463 Cj0129c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 outer membrane protein YP_002343589.1 129800 R 192222 CDS YP_002343590.1 218561811 904465 132096..132923 1 NC_002163.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 132923 tyrA 904465 tyrA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 prephenate dehydrogenase YP_002343590.1 132096 D 192222 CDS YP_002343591.1 218561812 904466 133003..134376 1 NC_002163.1 Original (2000) note: Cj0131, probable periplasmic protein, len: 457 aa; similar to hypothetical proteins e.g.TR:O25694 (EMBL:AE000754) Aquifex aeolicus AQ_1743 (422 aa), fasta scores; opt: 401 z-score: 635.2 E(): 4e-28, 30.0% identity in 420 aa overlap. 30.0% identity to HP1054. Contains probable N-terminal signal sequence. Also similar in C-terminus to Cj1235 (30.2% identity in 222 aa overlap); Updated (2006) note: Pfam domain PF01551 Peptidase family M23 identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity scores identified yet. Thus, kept within product function. Functional classification - Degradation of macromolecules - Proteins, peptides and glycopeptides; peptidase M23 family protein 134376 904466 Cj0131 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptidase M23 family protein YP_002343591.1 133003 D 192222 CDS YP_002343592.1 218561813 904467 134376..135260 1 NC_002163.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 135260 lpxC 904467 lpxC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_002343592.1 134376 D 192222 CDS YP_002343593.1 218561814 904469 135299..135700 1 NC_002163.1 Original (2000) note: Cj0133, unknown, len: 133 aa; 33.6% identity to HP1051; Updated (2006) note: Pfam domain PF00814 Glycoprotease family identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification - Degradation of macromolecules - Proteins,peptides and glycopeptides; glycoprotease family protein 135700 904469 Cj0133 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glycoprotease family protein YP_002343593.1 135299 D 192222 CDS YP_002343594.1 218561815 904490 135709..136587 1 NC_002163.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 136587 thrB 904490 thrB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 homoserine kinase YP_002343594.1 135709 D 192222 CDS YP_002343595.1 218561816 904470 136612..136869 1 NC_002163.1 Original (2000) note: Cj0135, unknown, len: 85 aa; 44.6% identity to HP1049; Updated (2006) note: Pfam PF04296 Protein of unknown function (DUF448) was present within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 136869 904470 Cj0135 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343595.1 136612 D 192222 CDS YP_002343596.1 218561817 904471 136856..139471 1 NC_002163.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 139471 infB 904471 infB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 translation initiation factor IF-2 YP_002343596.1 136856 D 192222 CDS YP_002343597.1 218561818 904468 139468..139830 1 NC_002163.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 139830 rbfA 904468 rbfA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribosome-binding factor A YP_002343597.1 139468 D 192222 CDS YP_002343598.1 218561819 904546 139820..140242 1 NC_002163.1 Original (2000) note: Cj0138, unknown, len: 140 aa; similar to hypothetical proteins e.g. YHBC_ECOLI (152 aa),fasta scores; opt: 272 z-score: 436.7 E(): 4.5e-17, 41.4% identity in 116 aa overlap. 38.9% identity to HP1046; Updated (2006) note: Pfam PF02576 Uncharacterised BCR, YhbC family was present within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 140242 904546 Cj0138 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343598.1 139820 D 192222 CDS YP_002343599.1 218561820 904929 140289..142640 1 NC_002163.1 Original (2000) note: Cj0139, possible endonuclease, len: 783 aa; similar in part to MCRB_ECOLI 5-methylcytosine-specific restriction enzyme B (465 aa),fasta scores; opt: 305 z-score: 505.4 E(): 6.7e-21, 40.9% identity in 186 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF07728 ATPase family associated with various cellular activities was identified within CDS. Characterised within Eschereichia coli with acceptable identity scores. Sequence alignment was only partial. Thus, kept within product function. Functional classification - DNA replication,restriction/modification, recombination and repair; PMID:7781618; endonuclease 142640 904929 Cj0139 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 endonuclease YP_002343599.1 140289 D 192222 CDS YP_002343600.1 218561821 904472 142633..143964 1 NC_002163.1 Original (2000) note: Cj0140, unknown, len: 443 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 143964 904472 Cj0140 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343600.1 142633 D 192222 CDS YP_002343601.1 218561822 904473 complement(143953..144756) 1 NC_002163.1 Original (2000) note: Cj0141c, ABC transporter integral membrane protein, len: 267 aa; similar to many e.g. MNTB_SYNY3 manganese transport system membrane protein (306 aa), fasta scores; opt: 425 z-score: 449.6 E(): 8.7e-18, 25.8% identity in 264 aa overlap. No Hp match. Contains Pfam match to entry PF00950 ABC-3, ABC 3 transport family, score 276.20, E-value 4.3e-79; Updated (2006) note: Seven probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. No specific characterisation with acceptable identity score identified. Thus, added to product function. Functional classification -Transport/binding proteins - Other; ABC transporter integral membrane protein 144756 904473 Cj0141c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter integral membrane protein YP_002343601.1 143953 R 192222 CDS YP_002343602.1 218561823 904475 complement(144749..145603) 1 NC_002163.1 Original (2000) note: Cj0142c, ABC transporter ATP-binding protein, len: 284 aa; simlar to many e.g. MNTA_SYNY3 manganese transport system ATP-binding protein (260 aa), fasta scores; opt: 417 z-score: 613.7 E(): 6.2e-27, 32.9% identity in 252 aa overlap. No Hp ortholog but 30.4% identity to HP0250 oligopeptide ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop),PS00211 ABC transporters family signature and Pfam match to entry PF00005 ABC_tran, ABC transporters, score 165.90,E-value 6.9e-46; Updated (2006) note: Some characterisation within Bacillus subtilis with acceptable identity score. Sequence alignment was only partial. Thus, added to product function. Functional classification -Transport/binding proteins - Other; PMID:10760146; ABC transporter ATP-binding protein 145603 904475 Cj0142c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter ATP-binding protein YP_002343602.1 144749 R 192222 CDS YP_002343603.1 218561824 904476 complement(145616..146506) 1 NC_002163.1 Original (2000) note: Cj0143c, probable periplasmic solute binding protein for ABC transport system, len: 296 aa; similar to e.g. ZNUA_ECOLI high-affinity zinc uptake system protein znuA (328 aa), fasta scores; opt: 386 z-score: 471.6 E(): 5.2e-19, 26.4% identity in 288 aa overlap. No Hp match. Contains probable N-terminal signal sequence and Pfam match to entry PF01297 Lipoprotein_4,score 133.20, E-value 4.6e-36; Updated (2006) note: Pfam domain PPF01297 Periplasmic solute binding protein identified within CDS. Further support given to product function. Some characterisation within Eschericia coli, however, identity score was marginal. Thus, kept within product function. Paper identified linking protein to glycoprotein (PMID:12186869). Also, found to have adhesin family signature. Functional classification - Transport/binding proteins - Other; PMID:9680209, PMID:12186869; periplasmic solute binding protein 146506 904476 Cj0143c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic solute binding protein YP_002343603.1 145616 R 192222 CDS YP_002343604.1 218561825 904478 146705..148684 1 NC_002163.1 Original (2000) note: Cj0144, probable methyl-accepting chemotaxis signal transduction protein,len: 659 aa; similar to mnay e.g. MCPS_ENTAE methyl-accepting chemotaxis serine transducer (557 aa),fasta scores; opt: 297 z-score: 493.4 E(): 3.2e-20, 28.6% identity in 377 aa overlap. No Hp ortholog. C-terminus contains repeat1, and is identical to the other repeat 1-containing genes Cj0262c and Cj1564. Contains N-terminal signal sequence and transmembrane anchor around aa 300. Also contains Pfam match to entry PF00015 MCPsignal,Methyl-accepting chemotaxis protein (MCP) signaling domain, score 110.60, E-value 4.1e-30; Updated (2006) note: Some characterisation work within Bacillus subtilis and Escherichia coli, however,identity scores were unnacceptable. Thus, kept within product function. Functional classification -Chemotaxis and mobility; PMID:6213619, PMID:7921238; methyl-accepting chemotaxis signal transduction protein 148684 904478 Cj0144 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methyl-accepting chemotaxis signal transduction protein YP_002343604.1 146705 D 192222 CDS YP_002343605.1 218561826 904480 148819..150600 1 NC_002163.1 Original (2000) note: Cj0145, unknown, len: 593 aa; some similarity to a hypothetical protein from Streptomyces coelicolor TR:O69840 (EMBL:AL023517) SC1B5.12C (465 aa), fasta scores; opt: 124 z-score: 327.1 E(): 5.8e-11, 23.0% identity in 574 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF05787 Bacterial protein of unknown function (DUF83), identified within CDS. TIGRFAM TIGR01409 TAT_signal_seq, Tat (twin-arginine translocation) pathway signal sequence identified within CDS. Product modified to more specific family member based on motif search results. No specific characterisation with acceptable identity scores carried out yet. Thus, kept within product function. Functional classification -Misc; PMID:10766774; TAT (Twin-Arginine Translocation) pathway signal sequence domain protein 150600 904480 Cj0145 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 TAT (Twin-Arginine Translocation) pathway signal sequence domain protein YP_002343605.1 148819 D 192222 CDS YP_002343606.1 218561827 904481 complement(150638..151576) 1 NC_002163.1 Original (2000) note: Cj0146c, trxB, probable thioredoxin reductase, len: 312 aa; similar to many e.g. TRXB_LISMO thioredoxin reductase (EC 1.6.4.5) (319 aa),fasta scores; opt: 749 z-score: 926.7 E(): 0, 38.0% identity in 313 aa overlap. 64.2% identity to HP0825. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site; Updated (2006) note: Pfam domain PF00070 Pyridine nucleotide-disulphide oxidoreductase identified within CDS. Further support given to product function. Characterised within Listeria monocytogenes with acceptable identity scores. Appropriate motifs identified. Thus, not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Thioredoxin; PMID:2644268, PMID:15358361; thioredoxin reductase 151576 trxB 904481 trxB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 thioredoxin reductase YP_002343606.1 150638 R 192222 CDS YP_002343607.1 218561828 904479 complement(151710..152024) 1 NC_002163.1 Original (2000) note: Cj0147c, trxA, thioredoxin,len: 104 aa; highly similar to many e.g. THIO_ECOLI thioredoxin 1 (108 aa), fasta scores; opt: 344 z-score: 590.5 E(): 1.2e-25, 45.7% identity in 105 aa overlap. 68.6% identity to HP0824. Contains PS00194 Thioredoxin family active site and Pfam match to entry PF00085 thiored, Thioredoxins, score 144.20, E-value 3.6e-42; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Thus, not added to product function. Appropiate motifs present. Paper identified linking protein to glycoprotein. Functional classification - Biosynthesis of cofactors,prosthetic groups and carriers - Thioredoxin; PMID:12186869, PMID:15358361; thioredoxin 152024 trxA 904479 trxA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 thioredoxin YP_002343607.1 151710 R 192222 CDS YP_002343608.1 218561829 904489 complement(152081..152419) 1 NC_002163.1 Original (2000) note: Cj0148c, unknown, len: 112 aa; similar to hypothetical proteins e.g. TR:G3323225 (EMBL:AE001259) Treponema pallidum TP0913 (126 aa), fasta scores; opt: 156 z-score: 253.1 E(): 7.6e-07, 31.0% identity in 100 aa overlap. 47.1% identity to HP0823; Updated (2006) note: Pfam PF02021 Uncharacterised protein family was present within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 152419 904489 Cj0148c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343608.1 152081 R 192222 CDS YP_002343609.1 218561830 904482 complement(152419..153666) 1 NC_002163.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 153666 hom 904482 hom Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 homoserine dehydrogenase YP_002343609.1 152419 R 192222 CDS YP_002343610.1 218561831 904483 complement(153670..154872) 1 NC_002163.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 154872 904483 Cj0150c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aspartate aminotransferase YP_002343610.1 153670 R 192222 CDS YP_002343611.1 218561832 904484 complement(154884..155690) 1 NC_002163.1 Original (2000) note: Cj0151c, possible periplasmic protein, len: 268 aa; 26.0% identity to HP0555. Contains possible N-terminal signal sequence. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 155690 904484 Cj0151c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343611.1 154884 R 192222 CDS YP_002343612.1 218561833 904485 complement(155684..156622) 1 NC_002163.1 Original (2000) note: Cj0152c, possible membrane protein, len: 312 aa; 25.0% identity to HP0554. Contains one probable transmembrane domain around aa 110. Functional classification - Membranes, lipoproteins and porins; hypothetical protein 156622 904485 Cj0152c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343612.1 155684 R 192222 CDS YP_002343613.1 218561834 904486 complement(156615..157298) 1 NC_002163.1 Original (2000) note: Cj0153c, probable rRNA methylase, len: 227 aa; similar to members of the spoU family e.g. NHS_STRAS 23S rRNA methyltransferase (274 aa), fasta scores; opt: 197 z-score: 247.9 E(): 1.5e-06,29.9% identity in 157 aa overlap. 42.7% identity to HP0553. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family, score 106.90,E-value 3.8e-28; Updated (2006) note: Characterised within Escherichia coli with marginal identity score. kept within product function. Functional classification -RNA synthesis, RNA modification and DNA transcription; PMID:11698387; rRNA methylase 157298 904486 Cj0153c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 rRNA methylase YP_002343613.1 156615 R 192222 CDS YP_002343614.1 218561835 904487 complement(157312..158136) 1 NC_002163.1 Original (2000) note: Cj0154c, possible methylase,len: 274 aa; similar to hypotehtical proteins e.g. YABC_BACSU (292 aa), fasta scores; opt: 453 z-score: 741.0 E(): 0, 32.9% identity in 289 aa overlap. 42.3% identity to HP0552. Contains PS01296 Uncharacterized protein family UPF0011 signature and Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases.,score 81.20, E-value 2.2e-20; Updated (2006) note: Pfam domain PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylase was identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity score has yet been carried out. Thus, kept within product function. Functional classification - Misc; tetrapyrrole methylase family protein 158136 904487 Cj0154c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tetrapyrrole methylase family protein YP_002343614.1 157312 R 192222 CDS YP_002343615.1 218561836 904488 complement(158139..158339) 1 NC_002163.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 158339 rpmE 904488 rpmE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L31 YP_002343615.1 158139 R 192222 CDS YP_002343616.1 218561837 904493 complement(158418..159074) 1 NC_002163.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 159074 904493 Cj0156c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 16S ribosomal RNA methyltransferase RsmE YP_002343616.1 158418 R 192222 CDS YP_002343617.1 218561838 904494 complement(159076..159483) 1 NC_002163.1 Original (2000) note: Cj0157c, probable integral membrane protein, len: 135 aa; no Hp match. Contains four probable transmembrane domains. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 159483 904494 Cj0157c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343617.1 159076 R 192222 CDS YP_002343618.1 218561839 904474 complement(159483..159908) 1 NC_002163.1 Original (2000) note: Cj0158c, possible haem-binding lipoprotein, len: 141 aa; no Hp match. Contains N-terminal signal sequence with appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site, PS00190 Cytochrome c family heme-binding site signature, and Pfam match to entry PF00034 cytochrome_c, Cytochrome c, score -3.00, E-value 0.87; Updated (2006) note: No specific characterisation with acceptable identity scores identified yet. kept within product function. Functional classification -Membranes, lipoproteins and porins; heme-binding lipoprotein 159908 904474 Cj0158c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 heme-binding lipoprotein YP_002343618.1 159483 R 192222 CDS YP_002343619.1 218561840 904501 complement(159908..160489) 1 NC_002163.1 Original (2000) note: Cj0159c, unknown, len: 193 aa; similar in N-terminus to hypothetical proteins e.g.TR:O27296 (EMBL:AE000890) Methanobacterium thermoautotrophicum MTH1228 (161 aa), fasta scores; opt: 140 z-score: 234.0 E(): 8.9e-06, 37.9% identity in 66 aa overlap. 35.8% identity to HP0933; Updated (2006) note: Pfam domain PF01242 6-pyruvoyl tetrahydropterin synthase was identified within CDS. Product modified to more specific family member due to motif match with own search. No specific characterisation with acceptable identity scores carried out yet. Thus, kept within product function. Functional classification - Misc; 6-pyruvoyl tetrahydropterin synthase 160489 904501 Cj0159c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 6-pyruvoyl tetrahydropterin synthase YP_002343619.1 159908 R 192222 CDS YP_002343620.1 218561841 904496 complement(160486..161229) 1 NC_002163.1 Original (2000) note: Cj0160c, unknown, len: 247 aa; similar to hypothetical proteins e.g. TR:O67826 (EMBL:AE000769) Aquifex aeolicus AQ_2035 (219 aa), fasta scores; opt: 130 z-score: 282.9 E(): 1.7e-08, 28.8% identity in 233 aa overlap. 43.1% identity to HP0934; Updated (2006) note: Pfam domain PF04055 Radical SAM superfamily was identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation carried out yet, so kept within product function. Functional classification - Misc; radical SAM domain protein 161229 904496 Cj0160c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 radical SAM domain protein YP_002343620.1 160486 R 192222 CDS YP_002343621.1 218561842 904499 complement(161232..162194) 1 NC_002163.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 162194 moaA 904499 moaA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molybdenum cofactor biosynthesis protein A YP_002343621.1 161232 R 192222 CDS YP_002343622.1 218561843 904500 complement(162207..162722) 1 NC_002163.1 Original (2000) note: Cj0162c, probable periplasmic protein, len: 171 aa; no Hp match. Contains probable N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 162722 904500 Cj0162c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343622.1 162207 R 192222 CDS YP_002343623.1 218561844 904502 complement(162719..163216) 1 NC_002163.1 Original (2000) note: Cj0163c, unknown, len: 165 aa; no Hp match. Functional classification - Unknown; hypothetical protein 163216 904502 Cj0163c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343623.1 162719 R 192222 CDS YP_002343624.1 218561845 904503 complement(163207..164091) 1 NC_002163.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; prenyltransferase 164091 ubiA 904503 ubiA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 prenyltransferase YP_002343624.1 163207 R 192222 CDS YP_002343625.1 218561846 904521 164162..165031 1 NC_002163.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 165031 miaA 904521 miaA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tRNA delta(2)-isopentenylpyrophosphate transferase YP_002343625.1 164162 D 192222 CDS YP_002343626.1 218561847 904504 complement(165017..165580) 1 NC_002163.1 Original (2000) note: Cj0167c, probable integral membrane protein, len: 187 aa; similar to hypothetical proteins e.g. YEBN_ECOLI (206 aa), fasta scores; opt: 451 z-score: 792.0 E(): 0, 38.1% identity in 197 aa overlap. No Hp match; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Also, Pfam domains x2 PF02659 Domain of unknown function DUF were identified within CDS. This family consists of hypothetical transmembrane proteins with unknown function. Further support given to product function. No specific characterisation yet, so included in product function. Functional classification - Membranes,lipoproteins and porins; integral membrane protein 165580 904504 Cj0167c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343626.1 165017 R 192222 CDS YP_002343627.1 218561848 904507 complement(165938..166105) 1 NC_002163.1 Original (2000) note: Cj0168c, probable periplasmic protein, len: 55 aa; No Hp ortholog. Some similarity in C-term to Cj0909 (35.0% identity in 40 aa overlap). Contains probable N-terminal signal sequence; Updated (2006) note: Literature search identified paper giving further support to product function. N-terminal matches to Yersinia pestis, acid shock protein 2 precursor. Functional classification - Miscellaneous periplasmic proteins; PMID:15632442; periplasmic protein 166105 904507 Cj0168c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343627.1 165938 R 192222 CDS YP_002343628.1 218561849 904414 166373..167035 1 NC_002163.1 Original (2000) note: Cj0169, sodB, superoxide dismutase (Fe), len: 220 aa; 99.1% identical to SODF_CAMJE, and highly simlar to many e.g. SODF_ECOLI superoxide dismutase (Fe) (EC 1.15.1.1) (192 aa), fasta scores; opt: 740 z-score: 1209.9 E(): 0, 57.9% identity in 195 aa overlap. 61.6% identity to HP0389. Contains PS00088 Manganese and iron superoxide dismutases signature and Pfam match to entry PF00081 sodfe, Iron/manganese superoxide dismutases (SODM), score 275.90, E-value 5.2e-79; Updated (2006) note: Characterised within Campylobacter jejuni, so not added. Paper identified linking protein to glycoprotein (PMID:12186869). Functional classification -Detoxification; PMID:12186869, PMID:8025686, PMID:8005660; superoxide dismutase 167035 sodB 904414 sodB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 superoxide dismutase YP_002343628.1 166373 D 192222 CDS YP_002343629.1 218561850 904508 join(167050..167295,167297..167794) 1 NC_002163.1 Original (2000) note: Cj0171, unknown, len: 166 aa; no Hp match. Contains polyporphic sequence G(9,11) at N-terminus; G11 allows translation from the upstream CDS Cj0170, G9 (consensus) would only allow this CDS to start at aa 47. Similar to Cj1326 (51.9% identity in 135 aa overlap), which also contains a polymorphic sequence allowing possible translation from Cj1325; Original (2000) note: Cj0170, unknown, len: 90 aa; no Hp match. Contains polyporphic sequence G(9,11) at C-terminus; G9 (consensus) gives this translation stop,G11 allows translation into the downstream CDS Cj0171. Similar to Cj1325 (73.8% identity in 61 aa overlap), which also contains a polymorphic sequence allowing possible translation into Cj1326; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Coding sequences have been merged to reflect the complete amino acid sequence for this gene regardless of phase. Previous annotation gave Cj0170 and Cj0171 as seperate CDS. Merging of these CDSs has lead to loss of the downstream CDS. Functional classification - Unknown; hypothetical protein 167794 904508 Cj0170 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343629.1 167050 D 192222 CDS YP_002343630.1 218561851 904510 complement(167807..169012) 1 NC_002163.1 Original (2000) note: Cj0172c, unknown, len: 401 aa; similar to hypothetical proteins e.g. TR:Q55131 (EMBL:D64001) Synechocystis sp. SLR0049 (398 aa), fasta scores; opt: 1534 z-score: 2324.2 E(): 0, 55.7% identity in 397 aa overlap. 63.8% identity to HP1507 conserved hypothetical ATP-binding protein; Updated (2006) note: Pfam domain PF03435 Saccharopine dehydrogenase was identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation has yet been carried out. kept within product function. Functional classification - Misc; saccharopine dehydrogenase 169012 904510 Cj0172c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 saccharopine dehydrogenase YP_002343630.1 167807 R 192222 CDS YP_002343631.1 218561852 904511 complement(169054..169962) 1 NC_002163.1 Original (2000) note: Cj0173c, possible iron-uptake ABC transport system ATP-binding protein, len: 302 aa; similar to many e.g. HITC_HAEIN iron(iii)-transport ATP-binding protein hitC (356 aa), fasta scores; opt: 389 z-score: 783.2 E(): 0, 38.0% identity in 250 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop),PS00211 ABC transporters family signature and Pfam match to entry PF00005 ABC_tran, ABC transporters, score 163.10,E-value 4.9e-45. No Hp ortholog; Updated (2006) note: Literature search identified many supporting papers within Campylobacter jejuni (PMID:12069882) and also paper carrying out the original work within Serratia marcescens. Designated as Campylobacter ferric binding protein (Cfbp) system. Characterisation with acceptable identity score yet to be carried out. Thus, kept within product function. Functional classification - Transport/binding proteins -Cations; PMID:15231804, PMID:12069882, PMID:15731081,PMID:2644190, PMID:7927717; iron-uptake ABC transporter ATP-binding protein 169962 cfbpC 904511 cfbpC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 iron-uptake ABC transporter ATP-binding protein YP_002343631.1 169054 R 192222 CDS YP_002343632.1 218561853 904512 complement(169946..171562) 1 NC_002163.1 Original (2000) note: Cj0174c, possible iron-uptake ABC transport system permease, len: 538 aa; similar to e.g. SFUB_SERMA iron(iii)-transport system permease (527 aa), fasta scores; opt: 333 z-score: 335.6 E(): 1.9e-11, 21.5% identity in 522 aa overlap. No Hp match. Contains Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component, score 27.90, E-value 0.00024; Updated (2006) note: Literature search identified many supporting papers within Campylobacter jejuni (PMID:12069882) and also paper carrying out the original work within Serratia marcescens. Designated as Campylobacter ferric binding protein (Cfbp) system. Characterisation with acceptable identity score yet to be carried out. Thus, kept within product function. Functional classification - Transport/binding proteins -Cations; PMID:15231804, PMID:12069882, PMID:15731081,PMID:2644190, PMID:7927717; iron-uptake ABC transporter permease 171562 cfbpB 904512 cfbpB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 iron-uptake ABC transporter permease YP_002343632.1 169946 R 192222 CDS YP_002343633.1 218561854 904513 complement(171562..172566) 1 NC_002163.1 Original (2000) note: Cj0175c, possible iron-uptake ABC transport system periplasmic iron-binding protein,len: 334 aa; similar to e.g. HITA_HAEIN iron-utilization periplasmic protein precursor (332 aa), fasta scores; opt: 466 z-score: 500.8 E(): 1.2e-20, 29.8% identity in 332 aa overlap. No Hp match. Contains N-terminal signal sequence; Updated (2006) note: Pfam domain PF01547 Bacterial extracellular solute-binding protein identified within CDS. Further support given to product function. Literature search identified many supporting papers within Campylobacter jejuni (PMID:12069882) and also paper carrying out the original work within Serratia marcescens. Designated as Campylobacter ferric binding protein (Cfbp) system. Characterisation with acceptable identity score yet to be carried out. Thus, kept within product function. Paper identified linked protein to glycoprotein (PMID:15231804). Functional classification -Transport/binding proteins - Cations; PMID:15613474, PMID:15231804, PMID:12069882,PMID:12186869, PMID:2644190; iron-uptake ABC transporter,periplasmic iron-binding protein 172566 cfbpA 904513 cfbpA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 iron-uptake ABC transporter,periplasmic iron-binding protein YP_002343633.1 171562 R 192222 CDS YP_002343634.1 218561855 904515 complement(172563..172694) 1 NC_002163.1 Original (2000) note: Cj0176c, probable lipoprotein, len: 43 aa; no Hp match. Contains N-terminal signal sequence with appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Literature search identified papers giving further clues to product function. Functional classification - Membranes, lipoproteins and porins; lipoprotein 172694 904515 Cj0176c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002343634.1 172563 R 192222 CDS YP_002343635.1 218561856 904516 172916..173767 1 NC_002163.1 Original (2000) note: Cj0177, probable lipoprotein,len: 283 aa; simlar to TR:O68876 (EMBL:AF055999) hypothetical protein PhuW from Pseudomonas aeruginosa hemin uptake locus (295 aa), fasta scores; opt: 375 z-score: 307.6 E(): 7.1e-10, 31.3% identity in 246 aa overlap. No Hp match. Contains N-terminal signal sequence with appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Pfam domain PF04187 Protein of unknown function, DUF399 identified within CDS. Literature search identified papers giving further clues to product function. Product function modified to iron transport protein based on information from literature. No specific characterisation with acceptable identity scores has been carried out yet. Thus, kept within product function. Functional classification -Transport/binding proteins - Cations; PMID:12069882, PMID:15231804, PMID:15231804; iron transport protein 173767 904516 Cj0177 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 iron transport protein YP_002343635.1 172916 D 192222 CDS YP_002343636.1 218561857 904518 173764..176031 1 NC_002163.1 Original (2000) note: Cj0178, possible outer membrane siderophore receptor, len: 755 aa; similar to e.g. YC17_HAEIN probable tonB-dependent receptor HI1217 (913 aa), fasta scores; opt: 440 z-score: 1818.4 E(): 0,32.7% identity in 912 aa overlap, and TR:O68881 (EMBL:AF055999) outer membrane hemin receptor PhuR from Pseudomonas aeruginosa (764 aa), fasta scores; opt: 145 z-score: 207.4 E(): 0.00027 22.3% identity in 806 aa overlap. No Hp match. Contains N-terminal signal sequence; Updated (2006) note: Pfam domains PF07715 TonB-dependent Receptor Plug Domain and PF00593 TonB dependent receptor identified within CDS. Literature search identified papers giving further clues to product function. Product function modified to more specific family member. No specific characterisation with acceptable identity scores has been carried out yet. Thus, kept within product function. Functional classification - Transport/binding proteins - Cations; PMID:15731081, PMID:15632442, PMID:15231804,PMID:12069882; TonB-denpendent outer membrane receptor 176031 904518 Cj0178 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 TonB-denpendent outer membrane receptor YP_002343636.1 173764 D 192222 CDS YP_002343637.1 218561858 904520 176043..176804 1 NC_002163.1 Original (2000) note: Cj0179, exbB1, biopolymer transport protein, len: 253 aa; highly similar to e.g. EXBB_ECOLI biopolymer transport exbB protein (244 aa),fasta scores; opt: 537 z-score: 811.2 E(): 0, 46.3% identity in 216 aa overlap. No Hp ortholog; Updated (2006) note: Pfam domain PF01618 MotA/TolQ/ExbB proton channel family identified within CDS. Also, three probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. Thus, not added. Cj0179-Cj0181 (exbB1, exbD1, tonB1) function as an outer-membrane energy transducer system. Functional classification -Transport/binding proteins - Other; PMID:7642501, PMID:8437515, PMID:15632442,PMID:12069882; biopolymer transport protein 176804 exbB1 904520 exbB1 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 biopolymer transport protein YP_002343637.1 176043 D 192222 CDS YP_002343638.1 218561859 904523 176791..177201 1 NC_002163.1 Original (2000) note: Cj0180, exbD1, biopolymer transport protein, len: 136 aa; highly similar to e.g. EXBD_ECOLI biopolymer transport exbD protein (141 aa),fasta scores; opt: 356 z-score: 629.2 E(): 8.7e-28, 42.9% identity in 119 aa overlap. No Hp ortholog; Updated (2006) note: Pfam domain PF02472 Biopolymer transport protein ExbD/TolR identified within CDS. Also,one probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised within Escherichia coli with acceptable identity scores. Thus, not added. Cj0179-Cj0181 (exbB1, exbD1,tonB1) function as an outer-membrane energy transducer system. Functional classification - Transport/binding proteins - Other; PMID:7642501, PMID:8437515, PMID:15632442,PMID:12069882; biopolymer transport protein 177201 exbD1 904523 exbD1 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 biopolymer transport protein YP_002343638.1 176791 D 192222 CDS YP_002343639.1 218561860 904524 177203..177949 1 NC_002163.1 Original (2000) note: Cj0181, tonB1, possible tonB transport protein, len 248 aa; similar to e.g. TONB_PSEPU tonB protein (243 aa), fasta scores; opt: 220 z-score: 317.2 E(): 2.1e-10, 29.5% identity in 149 aa overlap. No Hp match; Updated (2006) note: One probable transmembrane helices predicted by TMHMM2.0. Characterised within Pseudomonas putida with marginal identity score. not added. Cj0179-Cj0181 (exbB1, exbD1, tonB1) function as an outer-membrane energy transducer system. Functional classification - Transport/binding proteins - Other; PMID:7642501, PMID:8437515, PMID:15632442,PMID:12069882; TonB transport protein 177949 tonB1 904524 tonB1 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 TonB transport protein YP_002343639.1 177203 D 192222 CDS YP_002343640.1 218561861 904525 177995..179200 1 NC_002163.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transporter 179200 904525 Cj0182 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transporter YP_002343640.1 177995 D 192222 CDS YP_002343641.1 218561862 904526 179299..180657 1 NC_002163.1 Original (2000) note: Cj0183, probable integral membrane protein with haemolysin domain, len: 452 aa; similar to many members of the UPF0053 family e.g. YUGS_BACSU (434 aa), fasta scores; opt: 999 z-score: 1508.9 E(): 0, 38.1% identity in 430 aa overlap. Also similar in C-terminal half to haemolysins e.g. HLYC_TREHY Treponema hyodysenteriae hemolysin C (268 aa), fasta scores; opt: 447 z-score: 468.1 E(): 8.1e-19, 32.5% identity in 237 aa overlap. 54.3% identity to HP1490. Contains 2x Pfam match to entry PF00571 CBS, CBS domain,scores 26.10, E-value 0.00082 and 40.50, E-value 3.7e-08; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. No specific characterisation with acceptable identity scores identified yet. Thus, kept within product function. Functional classification - Pathogenicity; integral membrane protein 180657 904526 Cj0183 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343641.1 179299 D 192222 CDS YP_002343642.1 218561863 904527 complement(180702..181856) 1 NC_002163.1 Original (2000) note: Cj0184c, possible serine/threonine protein phosphatase, len: 384 aa; similar in part to many eukarotic serine/threonine protein phosphatases e.g. PP12_SCHPO serine/threonine protein phosphatase PP1-2 (322 aa), fasta scores; opt: 140 z-score: 290.0 E(): 6.8e-09, 31.3% identity in 131 aa overlap. No Hp match. Contains Pfam match to entry PF00149 STphosphatase, Ser/Thr protein phosphatases, score 6.90,E-value 0.39; Updated (2006) note: Pfam domain PF00149 STphosphatase was changed in Pfam database to Calcineurin-like phosphoesterase. Characterisation work has been carried out mainly in eukaryotes with marginal identity scores. Possible was changed to . Functional classification - Signal transduction; serine/threonine protein phosphatase 181856 904527 Cj0184c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 serine/threonine protein phosphatase YP_002343642.1 180702 R 192222 CDS YP_002343643.1 218561864 904528 complement(181866..182075) 1 NC_002163.1 Original (2000) note: Cj0185c, unknown, len: 69 aa; similar to part of phnA proteins (involved in alkylphosphonate uptake) from several organisms e.g. PHNA_ECOLI phnA protein (111 aa), fasta scores; opt: 238 z-score: 482.4 E(): 1.3e-19, 55.9% identity in 68 aa overlap. 45.6% identity in 68 aa overlap to HP0872 (109 aa); Updated (2006) note: Pfam domain PF03831 PhnA protein was identified within CDS. Characterisation work within Escherichia coli has been carried out with acceptable identity scores. However, sequence alignment was only partial. Product changed from phnA-like protein to phnA domain protein. Functional classification - Transport/binding proteins - Other; PMID:9300819; phnA domain protein 182075 904528 Cj0185c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phnA domain protein YP_002343643.1 181866 R 192222 CDS YP_002343644.1 218561865 904529 complement(182068..182787) 1 NC_002163.1 Original (2000) note: Cj0186c, probable integral membrane protein, len: 239 aa; similar to many hypothetical proteins e.g. YGDQ_HAEIN HI0056 (237 aa),fasta scores; opt: 964 z-score: 1727.7 E(): 0, 64.3% identity in 230 aa overlap. 50.0% identity to HP1343; Updated (2006) note: Pfam domain PF03741 Integral membrane protein TerC family was identified within CDS. Seven probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Product modified to more specific family member based on motif match. No specific characterisation with acceptable identity scores has been carried out yet. Thus, kept within product function. Functional classification -Membranes, lipoproteins and porins; TerC family integral membrane protein 182787 904529 Cj0186c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 TerC family integral membrane protein YP_002343644.1 182068 R 192222 CDS YP_002343645.1 218561866 904530 complement(182859..183425) 1 NC_002163.1 Original (2000) note: Cj0187c, purN, probable phosphoribosylglycinamide formyltransferase, len: 188 aa; similar to e.g. PUR3_ECOLI phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (212 aa), fasta scores; opt: 406 z-score: 654.6 E(): 3.3e-29, 38.6% identity in 189 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00551 formyl_transf, Formyl transferase, score 177.90, E-value 4.4e-50; Updated (2006) note: Characterised within Escherichia coli with acceptable identity scores. not added to product function. Functional classification -Purine ribonucleotide biosynthesis; PMID:3301838; phosphoribosylglycinamide formyltransferase 183425 purN 904530 purN Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoribosylglycinamide formyltransferase YP_002343645.1 182859 R 192222 CDS YP_002343646.1 218561867 904531 complement(183416..184786) 1 NC_002163.1 Original (2000) note: Cj0188c, unknown, len: 456 aa; similar to members of the UPF0031 family e.g. YJEF_ECOLI (515 aa), fasta scores; opt: 267 z-score: 441.8 E(): 2.4e-17, 29.9% identity in 418 aa overlap. 35.9% identity to HP1363. Contains PS01050 Uncharacterized protein family UPF0031 signature 2 and Pfam match to entry PF01256 UPF0031, Uncharacterized protein family UPF0031,score 96.30, E-value 6e-25; Updated (2006) note: Previous uncharacterised Pfam motifs have now been designated as PF01256 Carbohydrate kinase and PF03853 YjeF-related protein N-terminus. Product modified to more specific family member based on motif match. No specific characterisation has yet been carried out. kept within product function. Functional classification - Misc; kinase 184786 904531 Cj0188c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 kinase YP_002343646.1 183416 R 192222 CDS YP_002343647.1 218561868 904532 complement(184770..185468) 1 NC_002163.1 Original (2000) note: Cj0189c, unknown, len: 232 aa; similar to hypothetical proteins e.g. TR:P73622 (EMBL:D90908) Synechocystis sp. (249 aa), fasta scores; opt: 351 z-score: 629.7 E(): 8.1e-28, 30.1% identity in 246 aa overlap. No Hp match; Updated (2006) note: Pfam PF01936 Protein of unknown function (DUF88) was present within CDS. Conserved added to product function. Functional classification -Conserved hypothetical proteins; hypothetical protein 185468 904532 Cj0189c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343647.1 184770 R 192222 CDS YP_002343648.1 218561869 904533 complement(185470..186975) 1 NC_002163.1 Original (2000) note: Cj0190c, unknown, len: 501 aa; similar to prokaryotic hypothetical proteins e.g. YIFB_ECOLI (516 aa), fasta scores; opt: 670 z-score: 1088.3 E(): 0, 34.0% identity in 497 aa overlap, and more distantly to members of the eukaryotic MCM family of DNA replication regulatory factors e.g. MCM6_RAT DNA replication licensing factor MCM6 (509 aa), fasta scores; opt: 152 z-score: 247.8 E(): 1.5e-06, 23.5% identity in 345 aa overlap. 47.7% identity to HP0792 (anotated as sigma-54 interacting protein). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry PF01078 Mg_chelatase, Magnesium chelatase, subunit ChlI, score 127.80, E-value 2e-34. Functional classification - Misc; hypothetical protein 186975 904533 Cj0190c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343648.1 185470 R 192222 CDS YP_002343649.1 218561870 904534 complement(186972..187499) 1 NC_002163.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 187499 def 904534 def Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptide deformylase YP_002343649.1 186972 R 192222 CDS YP_002343650.1 218561871 906014 complement(187535..188119) 1 NC_002163.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 188119 clpP 906014 clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP-dependent Clp protease proteolytic subunit YP_002343650.1 187535 R 192222 CDS YP_002343651.1 218561872 904535 complement(188119..189453) 1 NC_002163.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 189453 tig 904535 tig Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 trigger factor YP_002343651.1 188119 R 192222 CDS YP_002343652.1 218561873 904536 189596..190168 1 NC_002163.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 190168 folE 904536 folE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GTP cyclohydrolase I YP_002343652.1 189596 D 192222 CDS YP_002343653.1 218561874 904537 190168..191553 1 NC_002163.1 involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 191553 fliI 904537 fliI Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellum-specific ATP synthase YP_002343653.1 190168 D 192222 CDS YP_002343654.1 218561875 904538 complement(191556..192893) 1 NC_002163.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 192893 purF 904538 purF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amidophosphoribosyltransferase YP_002343654.1 191556 R 192222 CDS YP_002343655.1 218561876 904539 complement(192895..193623) 1 NC_002163.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 193623 dapB 904539 dapB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dihydrodipicolinate reductase YP_002343655.1 192895 R 192222 CDS YP_002343656.1 218561877 904540 complement(193686..194867) 1 NC_002163.1 Original (2000) note: Cj0198c, unknown, len: 393 aa; similar to hypothetical proteins e.g. YCAJ_ECOLI (447 aa), fasta scores; opt: 339 z-score: 796.4 E(): 0, 32.8% identity in 381 aa overlap, and less strongly to several helicases e.g. RUVB_HELPY holliday junction DNA helicase ruvB (336 aa), fasta scores; opt: 204 z-score: 280.5 E(): 2.3e-08, 28.8% identity in 278 aa overlap. 49.9% identity to HP1026. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Pfam domain PF00004 ATPase family associated with various cellular activities (AAA),was identified within CDS. Further support given to product function. No specific characterisation has been carried out yet. Product function unchanged. Functional classification - DNA replication,restriction/modification, recombination and repair; recombination factor protein RarA 194867 904540 Cj0198c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 recombination factor protein RarA YP_002343656.1 193686 R 192222 CDS YP_002343657.1 218561878 904542 complement(194867..195988) 1 NC_002163.1 Original (2000) note: Cj0199c, probable periplasmic protein, len: 373 aa; no Hp match. Contains N-terminal signal sequence. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 195988 904542 Cj0199c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343657.1 194867 R 192222 CDS YP_002343658.1 218561879 904543 complement(196123..196470) 1 NC_002163.1 Original (2000) note: Cj0200c, probable periplasmic protein, len: 115 aa; no Hp match. Contains N-terminal signal sequence; Updated (2006) note: Literature search papers giving further clues to product function. Paper (PMID:12186869) links protein to glycoprotein. Functional classification - Miscellaneous periplasmic proteins; PMID:15554967, PMID:12186869; periplasmic protein 196470 904543 Cj0200c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343658.1 196123 R 192222 CDS YP_002343659.1 218561880 904544 complement(196534..197139) 1 NC_002163.1 Original (2000) note: Cj0201c, probable integral membrane protein, len: 201 aa; no Hp match. Contains possible transmembrane domain at N-terminus and PS00216 Sugar transport proteins signature 1. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 197139 904544 Cj0201c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343659.1 196534 R 192222 CDS YP_002343660.1 218561881 906013 complement(197123..197464) 1 NC_002163.1 Original (2000) note: Cj0202c, unknown, len: 113 aa. No Hp match. Functional classification - Unknown; hypothetical protein 197464 906013 Cj0202c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343660.1 197123 R 192222 CDS YP_002343661.1 218561882 904545 197707..199053 1 NC_002163.1 Original (2000) note: Cj0203, probable transmembrane transport protein, len: 448 aa; some similarity to e.g. CITM_BACSU Mg2+/citrate complex secondary transporter (433 aa), fasta scores; opt: 702 z-score: 964.3 E(): 0, 28.7% identity in 449 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03600 Citrate transporter was identified within CDS. Twelve probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member due to motif match. Some characterisation work has been carried out within Bacillus subtilis, however, identity scores were marginal. kept within product function. Functional classification - Transport/binding proteins -Other; PMID:8892821; citrate transporter 199053 904545 Cj0203 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 citrate transporter YP_002343661.1 197707 D 192222 CDS YP_002343662.1 218561883 904548 199236..201233 1 NC_002163.1 Original (2000) note: Cj0204, probable integral membrane protein, len: 665 aa; 98.9% identity in 369 aa overlap to TR:Q46110 (EMBL:X76062) C. jejuni ORF CJO1.1 (381 aa). Similar to hypothetical proteins e.g. Y561_HAEIN HI0561/560 (633 aa), fasta scores; opt: 2119 z-score: 1501.8 E(): 0, 53.6% identity in 640 aa overlap, and in C-terminus to TR:Q51156 (EMBL:L09189) Neisseria meningitidis ORF associated with capsule gene complex (282 aa), fasta scores; opt: 880 z-score: 1097.6 E(): 0, 51.3% identity in 273 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03169 OPT oligopeptide transporter protein was identified within CDS. Sixteen probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member due to motif match. kept within product function. Functional classification - Transport/binding proteins -Other; PMID:7489896; oligopeptide transporter, OPT family 201233 904548 Cj0204 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 oligopeptide transporter, OPT family YP_002343662.1 199236 D 192222 CDS YP_002343663.1 218561884 904549 201307..202110 1 NC_002163.1 Original (2000) note: Cj0205, bacA, possible undecaprenol kinase (bacitracin resistance protein), len: 267 aa; 98.6% identity in 138 aa overlap to TR:Q46111 C. jejuni ORF CJO1.2 (138 aa). Simlar to e.g. BACA_ECOLI bacitracin resistance protein ( undecaprenol kinase) (273 aa), fasta scores; opt: 483 z-score: 947.5 E(): 0, 43.7% identity in 270 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02673 Bacitracin resistance protein BacA was identified within CDS. Seven probable transmembrane helices predicted by TMHMM2.0. Literature search identified characterisation papers within Escherichia coli that show further specification with product functionality (PMID:15778224). Product function modified to more specific family member. Identity scores were acceptable. Thus, not added to product function. Functional classification -Drug/analogue sensitivity; PMID:7489896, PMID:8389741, PMID:15138271,PMID:15778224; UDP-diphosphatase 202110 uppP 904549 uppP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-diphosphatase YP_002343663.1 201307 D 192222 CDS YP_002343664.1 218561885 904952 202241..204049 1 NC_002163.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 204049 thrS 904952 thrS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 threonyl-tRNA synthetase YP_002343664.1 202241 D 192222 CDS YP_002343665.1 218561886 904550 204046..204564 1 NC_002163.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 204564 infC 904550 infC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 translation initiation factor IF-3 YP_002343665.1 204046 D 192222 CDS YP_002343666.1 218561887 904551 204603..205694 1 NC_002163.1 Original (2000) note: Cj0208, probable DNA modification methylase (adenine-specific methyltransferase), len: 363 aa; similar to many e.g. MTN3_NEILA modification methylase NlaIII (EC 2.1.1.72) (334 aa), fasta scores; opt: 215 z-score: 401.1 E(): 4.4e-15, 31.7% identity in 366 aa overlap. 29.6% identity to HP1208 ulcer associated adenine specific DNA methyltransferase. Contains PS00092 N-6 Adenine-specific DNA methylases signature; Updated (2006) note: Pfam domain PF02086 D12 class N6 adenine-specific DNA methyltransferase was identified within CDS. Further support given to product function. Characterised within Neisseria lactamica with marginal identity scores. kept within product function. Functional classification - DNA replication,restriction/modification, recombination and repair; PMID:2277628; DNA modification methylase 205694 904551 Cj0208 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA modification methylase YP_002343666.1 204603 D 192222 CDS YP_002343667.1 218561888 906012 209279..210307 1 NC_002163.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 210307 argC 906012 argC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 N-acetyl-gamma-glutamyl-phosphate reductase YP_002343667.1 209279 D 192222 CDS YP_002343668.1 218561889 904553 210317..210763 1 NC_002163.1 Original (2000) note: Cj0225, probable acetyltransferase, len: 148 aa; some simlarity to STA_ECOLI streptothricin acetyltransferase (plasmid borne)(EC 2.3.-.-) (174 aa), fasta scores; opt: 118 z-score: 186.2 E(): 0.0041, 27.3% identity in 110 aa overlap. No Hp match. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 57.00, E-value 4.1e-13; Updated (2006) note: Characterisation carried out within Escherichia coil, however, identity score was marginal. kept within product function. Functional classification - Misc; PMID:2157196; acetyltransferase 210763 904553 Cj0225 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetyltransferase YP_002343668.1 210317 D 192222 CDS YP_002343669.1 218561890 904554 210767..211612 1 NC_002163.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 211612 argB 904554 argB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetylglutamate kinase YP_002343669.1 210767 D 192222 CDS YP_002343670.1 218561891 904555 211616..212803 1 NC_002163.1 Original (2000) note: Cj0227, argD, probable acetylornithine aminotransferase, len: 395 aa; simlar to many e.g. ARGD_ECOLI acetylornithine aminotransferase (EC 2.6.1.11) (406 aa), fasta scores; opt: 921 z-score: 1042.0 E(): 0, 36.6% identity in 385 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00202 aminotran_3,Aminotransferases class-III pyridoxal-phosphate, score 378.20, E-value 5.1e-131; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Based on current literature, product function has been modified and additional EC number has been added. kept within product function. Functional classification - Amino acid biosynthesis - Glutamate family; PMID:10588044, PMID:10074354; acetylornithine/succinyldiaminopimelate aminotransferase 212803 argD 904555 argD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetylornithine/succinyldiaminopimelate aminotransferase YP_002343670.1 211616 D 192222 CDS YP_002343671.1 218561892 906010 complement(212822..213451) 1 NC_002163.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 213451 pcm 906010 pcm Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 protein-L-isoaspartate O-methyltransferase YP_002343671.1 212822 R 192222 CDS YP_002343672.1 218561893 904556 213540..214088 1 NC_002163.1 Original (2000) note: Cj0229, possible acetyltransferase, len: 182 aa; similar to e.g. CAIE_ECOLI carnitine operon protein caiE (203 aa), fasta scores; opt: 251 z-score: 517.5 E(): 1.4e-21, 33.1% identity in 169 aa overlap. No Hp ortholog. Contains 3x Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats), scores 16.60, E-value 0.0071; 9.10, E-value 0.97 and 24.70, E-value 3.7e-05; Updated (2006) note: Some characterisation work within Escherichia coli, however, identity score was marginal. kept within product function. Functional classification - Misc; PMID:7815937; acetyltransferase 214088 904556 Cj0229 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetyltransferase YP_002343672.1 213540 D 192222 CDS YP_002343673.1 218561894 904557 complement(214057..215430) 1 NC_002163.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 215430 904557 Cj0230c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 nicotinate phosphoribosyltransferase YP_002343673.1 214057 R 192222 CDS YP_002343674.1 218561895 904558 complement(215417..216439) 1 NC_002163.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 216439 nrdF 904558 nrdF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribonucleotide-diphosphate reductase subunit beta YP_002343674.1 215417 R 192222 CDS YP_002343675.1 218561896 904559 complement(216453..216863) 1 NC_002163.1 Original (2000) note: Cj0232c, probable integral membrane protein, len: 136 aa; 37.9% identity to HP1258 (called conserved hypothetical mitochondrial protein 4). Contains three possible transmembrane domains; Updated (2006) note: Pfam domain PF06271 RDD family was identified within CDS. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 216863 904559 Cj0232c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343675.1 216453 R 192222 CDS YP_002343676.1 218561897 904560 complement(216864..217472) 1 NC_002163.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 217472 pyrE 904560 pyrE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 orotate phosphoribosyltransferase YP_002343676.1 216864 R 192222 CDS YP_002343677.1 218561898 904561 complement(217475..218038) 1 NC_002163.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 218038 frr 904561 frr Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribosome recycling factor YP_002343677.1 217475 R 192222 CDS YP_002343678.1 218561899 904562 complement(218048..218419) 1 NC_002163.1 Original (2000) note: Cj0235c, secG, possible protein-export membrane protein, len: 123 aa; similar to e.g. SECG_PSESY protein-export membrane protein secG (126 aa), fasta scores; opt: 157 z-score: 210.5 E(): 0.00018,25.2% identity in 119 aa overlap. 48.8% identity to HP1255; Updated (2006) note: Pfam domain PF03840 Preprotein translocase SecG subunit was identified within CDS. Also,two probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. No specific characterisation with acceptable identity scores have been carried out yet. kept within product function. Functional classification - Protein and peptide secretion; preprotein translocase subunit SecG 218419 secG 904562 secG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 preprotein translocase subunit SecG YP_002343678.1 218048 R 192222 CDS YP_002343679.1 218561900 904563 complement(218523..219218) 1 NC_002163.1 Original (2000) note: Cj0236c, probable integral membrane protein, len: 231 aa similar to members of the UPF0005 family e.g. YCCA_PSEAE (222 aa), fasta scores; opt: 377 z-score: 628.9 E(): 8.9e-28, 37.7% identity in 207 aa overlap. 49.1% identity to HP0920. Contains Pfam match to entry PF01027 UPF0005, Uncharacterized protein family, score 128.30, E-value 1.4e-34; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 219218 904563 Cj0236c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343679.1 218523 R 192222 CDS YP_002343680.1 218561901 904564 219378..220013 1 NC_002163.1 Original (2000) note: Cj0237, cynT, probable carbonic anyhydrase, len: 211 aa; similar to e.g. CYNT_ECOLI carbonic anhydrase (EC 4.2.1.1) (219 aa), fasta scores; opt: 541 z-score: 776.7 E(): 0, 41.2% identity in 204 aa overlap. 43.5% identity to HP0004. Contains PS00704 and PS00705 Prokaryotic-type carbonic anhydrases signatures 1 and 2, and Pfam match to entry PF00484 Pro_CA, Prokaryotic-type carbonic anhydrases, score 208.10, E-value 2.7e-59; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Central intermediary metabolism - General; PMID:1740425, PMID:14563877; carbonic anyhydrase 220013 cynT 904564 cynT Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 carbonic anyhydrase YP_002343680.1 219378 D 192222 CDS YP_002343681.1 218561902 904565 220010..221893 1 NC_002163.1 Original (2000) note: Cj0238, probable integral membrane protein, len: 627 aa; similar in C-terminus to many hypothetical proteins, e.g. YB43_METJA MJ1143 (361 aa), fasta scores; opt: 413 z-score: 535.7 E(): 1.4e-22,23.9% identity in 372 aa overlap. 36.3% identity in 608 aa overlap to HP0415. Contains Pfam match to entry PF00924 UPF0003, Uncharacterized protein family UPF0003, score 145.90, E-value 6.9e-40; Updated (2006) note: Pfam domain PF00924 Mechanosensitive ion channel was identified within CDS. Product modified to more specific family member due to motif match. Paper identified linking protein to glycoprotein. No specific characterisation has been carried out yet, so kept within product function. Functional classification - Transport/binding proteins -Other; mechanosensitive ion channel family protein 221893 904565 Cj0238 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 mechanosensitive ion channel family protein YP_002343681.1 220010 D 192222 CDS YP_002343682.1 218561903 904566 complement(221916..222887) 1 NC_002163.1 Original (2000) note: Cj0239c, nifU protein homolog, len: 323 aa; similar to many e.g. NIFU_AZOVI nifU protein (312 aa), fasta scores; opt: 627 z-score: 910.4 E(): 0, 37.0% identity in 330 aa overlap. 68.8% identity to HP0221. Also similar in C-terminus to Cj1639 (38.2% identity in 76 aa overlap). Contains Pfam match to entry PF01106 NifU-like, NifU-like domain, score 100.40, E-value 3.5e-26; Updated (2006) note: Pfam domains PF01592 NifU-like N terminal domain and PF04324 which is a BFD-like [2Fe-2S] binding domain identified within CDS. Further support given to product function. Functional classification -Conserved hypothetical proteins; PMID:7947754, PMID:10819462; NifU protein 222887 904566 Cj0239c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NifU protein YP_002343682.1 221916 R 192222 CDS YP_002343683.1 218561904 904567 complement(222897..224078) 1 NC_002163.1 Original (2000) note: Cj0240c, probable aminotransferase (nifS protein homolog), len: 393 aa; similar to many e.g. NIFS_KLEPN nifS protein (397 aa),fasta scores; opt: 1067 z-score: 1533.6 E(): 0, 47.0% identity in 383 aa overlap. 62.8% identity to HP0220. Contains PS00132 Zinc carboxypeptidases, zinc-binding region 1 signature, PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site, and Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V,score 358.80, E-value 5.9e-104; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Product modified to more specific family member based on characterisation papers. not added to product function. Functional classification - Misc; PMID:10908675, PMID:10781607, PMID:12860127,PMID:3040672, PMID:8464885; cysteine desulfurase 224078 iscS 904567 iscS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cysteine desulfurase YP_002343683.1 222897 R 192222 CDS YP_002343684.1 218561905 904568 complement(224256..224657) 1 NC_002163.1 Original (2000) note: Cj0241c, possible iron-binding protein, len: 133 aa; Weak similarity to members of the eukaryotic iron-binding hemerythrin family,e.g. HEMT_LINUN hemerythrin alpha chain (117 aa), fasta scores; opt: 93 z-score: 135.4 E(): 3.1, 27.3% identity in 77 aa overlap. Note that all of the iron-binding residues are conserved. No Hp match. Also similar to Cj1224 (34.7% identity in 118 aa overlap), Cj0072c (40.5% identity in 79 aa overlap) and Cj0045c (30.9% identity in 123 aa overlap); Updated (2006) note: Pfam domain PF01814 Hemerythrin HHE cation binding domain identified within CDS. No specific characterisation with acceptable identity score has been carried out yet. Thus, kept within product function. Functional classification -Transport/binding proteins - Cations; iron-binding protein 224657 904568 Cj0241c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 iron-binding protein YP_002343684.1 224256 R 192222 CDS YP_002343685.1 218561906 904569 complement(224794..225960) 1 NC_002163.1 Original (2000) note: Cj0243c, unknown, len: 388 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 225960 904569 Cj0243c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343685.1 224794 R 192222 CDS YP_002343686.1 218561907 904570 226116..226307 1 NC_002163.1 Original (2000) note: Cj0244, rpmI, 50s ribosomal protein L35, len: 63 aa; similar to many e.g. RL35_ECOLI 50s ribosomal protein L35 (64 aa), fasta scores; opt: 133 z-score: 282.3 E(): 1.8e-08. 45.6% identity in 57 aa overlap. 60.7% identity to HP0125; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Ribosomal protein synthesis and modification; PMID:16272117; 50S ribosomal protein L35 226307 rpmI 904570 rpmI Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L35 YP_002343686.1 226116 D 192222 CDS YP_002343687.1 218561908 904571 226401..226754 1 NC_002163.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 226754 rplT 904571 rplT Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L20 YP_002343687.1 226401 D 192222 CDS YP_002343688.1 218561909 904572 complement(226807..227934) 1 NC_002163.1 Original (2000) note: Cj0246c, probable MCP-domain signal transduction protein, len: 375 aa; similar in C-terminus to many MCP-domain containing proteins e.g. MCPA_BACSU methyl-accepting chemotaxis protein mcpA (661 aa), fasta scores; opt: 257 z-score: 408.0 E(): 1.8e-15,33.2% identity in 205 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00015 MCPsignal, Methyl-accepting chemotaxis protein (MCP) signaling domain, score 93.20,E-value 3.9e-25; Updated (2006) note: Characterisation within Bacillus subtilis, however, identity score was marginal. kept within product function. Functional classification - Signal transduction; PMID:8188684; MCP-domain signal transduction protein 227934 904572 Cj0246c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MCP-domain signal transduction protein YP_002343688.1 226807 R 192222 CDS YP_002343689.1 218561910 904573 complement(227910..228443) 1 NC_002163.1 Original (2000) note: Cj0247c, unknown, len: 177 aa; no Hp match; Updated (2006) note: Similar to proteins from other bacteria. Functional classification - Unknown; hypothetical protein 228443 904573 Cj0247c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343689.1 227910 R 192222 CDS YP_002343690.1 218561911 904574 228946..229803 1 NC_002163.1 Original (2000) note: Cj0248, unknown, len: 285 aa; no Hp match; Updated (2006) note: Similar to proteins from other bacteria. Literature search identified papers giving structural characterisation and clues to product function. Currently unknown function but may be some kind of hydrolase or signal-transduction protein. Cj0248 has been implicated as a virulence factor and has been shown to play a role in motility. Functional classification -Unknown; PMID:16287129, PMID:15066034, PMID:11298288; hypothetical protein 229803 904574 Cj0248 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343690.1 228946 D 192222 CDS YP_002343691.1 218561912 904575 229831..230310 1 NC_002163.1 Original (2000) note: Cj0249, unknown, len: 159 aa; no Hp match. Functional classification - Unknown; hypothetical protein 230310 904575 Cj0249 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343691.1 229831 D 192222 CDS YP_002343692.1 218561913 904576 complement(230279..231589) 1 NC_002163.1 Original (2000) note: Cj0250c, probable transmembrane transport protein, len: 436 aa; similar to many members of the sugar transport protein family, e.g. PROP_ECOLI proline/betaine transporter (500 aa), fasta scores; opt: 602 z-score: 791.3 E(): 0, 31.7% identity in 394 aa overlapCIT1_SALTY citrate-proton symport (citrate transporter) (434 aa), fasta scores; opt: 580 z-score: 734.9 E(): 0, 28.0% identity in 396 aa overlap. 50.9% identity to HP0936. Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporters, score 93.10,E-value 5.5e-24; Updated (2006) note: Pfam domain PF07690 Major Facilitator Superfamily was identified within CDS in addition to previous PF0083. Prosite domain PS50850 MFS,Major facilitator superfamily was also identified. Also,twelve probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member due to motif match. kept within product function. Functional classification - Transport/binding proteins -Other; MFS transport protein 231589 904576 Cj0250c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MFS transport protein YP_002343692.1 230279 R 192222 CDS YP_002343693.1 218561914 904577 complement(231592..231747) 1 NC_002163.1 Original (2000) note: Cj0251c, highly acidic protein, len: 51 aa; 47.9% identity to HP0756. Functional classification - Conserved hypothetical proteins; highly acidic protein 231747 904577 Cj0251c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 highly acidic protein YP_002343693.1 231592 R 192222 CDS YP_002343694.1 218561915 904578 231840..232313 1 NC_002163.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 232313 moaC 904578 moaC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molybdenum cofactor biosynthesis protein MoaC YP_002343694.1 231840 D 192222 CDS YP_002343695.1 218561916 904579 232291..232554 1 NC_002163.1 Original (2000) note: Cj0253, unknown, len: 87 aa; 33.8% identity to HP0495. Functional classification -Conserved hypothetical proteins; hypothetical protein 232554 904579 Cj0253 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343695.1 232291 D 192222 CDS YP_002343696.1 218561917 904580 232544..233704 1 NC_002163.1 Original (2000) note: Cj0254, unknown, len: 386 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 233704 904580 Cj0254 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343696.1 232544 D 192222 CDS YP_002343697.1 218561918 904581 complement(233723..234481) 1 NC_002163.1 Original (2000) note: Cj0255c, probable exodeoxyribonuclease, len: 252 aa; similar to many e.g. EXOA_BACSU exodeoxyribonuclease (EC 3.1.11.2)(252 aa),fasta scores; opt: 676 z-score: 868.1 E(): 0, 40.5% identity in 259 aa overlap. 41.1% identity to HP1526. Contains Pfam match to entry PF01260 AP_endonulease1, AP endonucleases family 1, score 282.10, E-value 7.3e-81; Updated (2006) note: Pfam domain PF03372,Endonuclease/Exonuclease/phosphatase family identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with acceptable identity score. not added to product function. Functional classification - DNA replication,restriction/modification, recombination and repair; PMID:10540738; exodeoxyribonuclease 234481 exoA 904581 exoA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 exodeoxyribonuclease YP_002343697.1 233723 R 192222 CDS YP_002343698.1 218561919 904582 234599..236137 1 NC_002163.1 Original (2000) note: Cj0256, probable integral membrane protein, len: 512 aa; similar to hypothetical proteins e.g. YJDB_ECOLI (547 aa), fasta scores; opt: 646 z-score: 1169.8 E(): 0, 38.9% identity in 530 aa overlap. 34.1% identity to HP0022; Updated (2006) note: Pfam domain PF00884 Sulfatase identified within CDS. Also, five probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member based on motif match. No specific characterisation has been carried out yet, so kept within product function. Literature search identified paper giving further clues to product function. Functional classification - Misc; PMID:11895937; sulfatase family protein 236137 904582 Cj0256 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sulfatase family protein YP_002343698.1 234599 D 192222 CDS YP_002343699.1 218561920 904583 236134..236490 1 NC_002163.1 Original (2000) note: Cj0257, dgkA, probale diacylglycerol kinase, len: 118 aa; similar to many e.g. KDGL_ECOLI diacylglycerol kinase (EC 2.7.1.107) (121 aa),fasta scores; opt: 263 z-score: 425.4 E(): 1.9e-16, 41.7% identity in 108 aa overlap. 38.7% identity to HP0700. Contains PS01069 Prokaryotic diacylglycerol kinase signature and Pfam match to entry PF01219 DAGK_prokar,Prokaryotic diacylglycerol kinase, score 114.40, E-value 2.2e-30; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Synthesis and modification of macromolecules -Phospholipids; PMID:2984194, PMID:3015952; diacylglycerol kinase 236490 dgkA 904583 dgkA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 diacylglycerol kinase YP_002343699.1 236134 D 192222 CDS YP_002343700.1 218561921 904584 236487..236732 1 NC_002163.1 Original (2000) note: Cj0258, possible DNA binding protein, len: 81 aa; no Hp match. Contains probable helix-turn-helix motif at aa 35-56 (Score 1128, +3.03 SD); Updated (2006) note: Pfam domain PF01022 Bacterial regulatory protein, arsR family was identified within CDS. This was found by carrying out own Pfam search. Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet, so kept within product function. Literature search identified paper with some additional information. Functional classification - Broad regulatory functions; PMID:15231810; ArsR family transcriptional regulator 236732 904584 Cj0258 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ArsR family transcriptional regulator YP_002343700.1 236487 D 192222 CDS YP_002343701.1 218561922 904585 236722..237729 1 NC_002163.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 237729 pyrC 904585 pyrC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dihydroorotase YP_002343701.1 236722 D 192222 CDS YP_002343702.1 218561923 904586 complement(237761..237976) 1 NC_002163.1 Original (2000) note: Cj0260c, unknown, len: 71 aa; no Hp match, very hydrophobic; Updated (2006) note: Two probable transmembrane helices identified by TMHMM2.0. Functional classification - Unknown; hypothetical protein 237976 904586 Cj0260c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343702.1 237761 R 192222 CDS YP_002343703.1 218561924 904587 complement(238032..238751) 1 NC_002163.1 Original (2000) note: Cj0261c, unknown, len: 239 aa; some similarity in N-terminus to YC73_HAEIN hypothetical protein HI1273 (268 aa), fasta scores; opt: 208 z-score: 260.9 E(): 2.8e-07, 29.0% identity in 176 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF08241 and PF08242 Methyltransferase domains were identified within CDS. ProfileScan also identified PS50193 SAM_BIND domain. Members from methyltransferase family are SAM dependent methyltransferases. This was found by carrying out own Pfam search. Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet, so kept within product function. Functional classification - Misc; SAM-dependent methyltransferase 238751 904587 Cj0261c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 SAM-dependent methyltransferase YP_002343703.1 238032 R 192222 CDS YP_002343704.1 218561925 904377 complement(238832..240829) 1 NC_002163.1 Original (2000) note: Cj0262c, probable methyl-accepting chemotaxis signal transduction protein,len: 665 aa; similar to many e.g. TR:O32443 (EMBL:D86947) Pseudomonas aeruginosa chemotactic transducer (629 aa),fasta scores; opt: 283 z-score: 635.0 E(): 4.1e-28, 25.3% identity in 667 aa overlap, and MCP1_ECOLI methyl-accepting chemotaxis protein I (551 aa), fasta scores; opt: 280 z-score: 519.1 E(): 1.2e-21. 29.1% identity in 302 aa overlap. No Hp ortholog. C-terminus contains repeat1, and is identical to the other repeat 1-containing genes Cj0262c and Cj1564. Contains N-terminal signal sequence and transmembrane anchor around aa 300. Also contains Pfam match to entry PF00015 MCPsignal,Methyl-accepting chemotaxis protein (MCP) signaling domain, score 110.60, E-value 4.1e-30; Updated (2006) note: Pfam motifs PF05581 Vibrio chemotaxis protein N terminus, PF02743 Cache domain and PF00672 HAMP domain were identified within CDS. Further support given to product function. Literature search identified supporting papers giving further clues to product function. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Chemotaxis and mobility; PMID:14985343, PMID:15066034; methyl-accepting chemotaxis signal transduction protein 240829 904377 Cj0262c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methyl-accepting chemotaxis signal transduction protein YP_002343704.1 238832 R 192222 CDS YP_002343705.1 218561926 904588 241022..241897 1 NC_002163.1 Original (2000) note: Cj0263, probable integral membrane protein, len: 291 aa; similar to hypothetical proteins e.g. YGIE_ECOLI (257 aa), fasta scores; opt: 498 z-score: 952.9 E(): 0, 40.0% identity in 280 aa overlap and GUFA_MYXXA (254 aa), fasta scores; opt: 252 z-score: 298.8 E(): 2.2e-09, 26.3% identity in 285 aa overlap. No Hp match. Contains PS00107 Protein kinases ATP-binding region signature; Updated (2006) note: Pfam domain PF02535 ZIP Zinc transporter was identified within CDS. Eight probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member due to motif match. Characterised within Escherichia coli with acceptable identity score. Thus, not added. Functional classification - Transport/binding proteins -Other; PMID:11790762, PMID:15716430; zinc transporter ZupT 241897 904588 Cj0263 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 zinc transporter ZupT YP_002343705.1 241022 D 192222 CDS YP_002343706.1 218561927 904589 complement(241921..244437) 1 NC_002163.1 Original (2000) note: Cj0264c, probable molybdopterin-containing oxidoreductase, len: 838 aa; highly similar to many e.g. DMSA_RHOSH dimethyl sulfoxide reductase precursor (822 aa), fasta scores; opt: 1343 z-score: 2990.1 E(): 0, 46.8% identity in 842 aa overlap,and BISC_ECOLI biotin sulfoxide reductase 1 (739 aa),fasta scores; opt: 1263 z-score: 2612.9 E(): 0, 46.7% identity in 766 aa overlap. 40.9% identity to HP0407. Contains PS00017 ATP/GTP-binding site motif A (P-loop),PS00932 Prokaryotic molybdopterin oxidoreductases signature 3, Pfam match to entry PF00384 molybdopterin,Prokaryotic molybdopterin oxidoreductases, score 110.50,E-value 9.4e-35 and N-terminal signal sequence; Updated (2006) note: Characterisation work in more than one species with acceptable identity scores. Characterisation work within Campylobacter jejuni shows that Cj0264c is responsible for both trimethylamine-N-oxide (TMAO) and dimethyl sulfoxide (DMSO) reduction. not added to product function. Functional classification - Misc; PMID:12107136, PMID:11004177, PMID:8645727; molybdopterin containing oxidoreductase 244437 904589 Cj0264c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molybdopterin containing oxidoreductase YP_002343706.1 241921 R 192222 CDS YP_002343707.1 218561928 904590 complement(244448..245023) 1 NC_002163.1 Original (2000) note: Cj0265c, probable cytochrome C-type haem-binding periplasmic protein, len: 191 aa; possibly part of electron-transport chain for oxidoreductase Cj0264c. Similar to C-terminus of many e.g. YECK_ECOLI probable cytochrome C-TYPE protein in bisZ-cutC intergenic region (366 aa), fasta scores; opt: 208 z-score: 216.4 E(): 8.5e-05, 27.0% identity in 163 aa overlap, and TORC_ECOLI cytochrome C-type protein torC (390 aa), fasta scores; opt: 264 z-score: 216.0 E(): 8.9e-05, 26.4% identity in 178 aa overlap. No Hp match. Contains N-terminal signal sequence and PS00190 Cytochrome c family heme-binding site signature; Updated (2006) note: Characterised within Escherichia coli, however, identity score was marginal. kept within product function. Functional classification - Energy metabolism - Electron transport; PMID:11562502, PMID:11056172; cytochrome C-type haem-binding periplasmic protein 245023 904590 Cj0265c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytochrome C-type haem-binding periplasmic protein YP_002343707.1 244448 R 192222 CDS YP_002343708.1 218561929 904591 complement(245504..246013) 1 NC_002163.1 Original (2000) note: Cj0266c, probable integral membrane protein, len: 169 aa; no Hp match; Updated (2006) note: Two probable transmembrane helices identified by TMHMM2.0. Prosite PS00430 TONB_DEPENDENT_REC_1, TonB box, N-terminal also identified. No specific characterisation has been carried out yet. kept within product function. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 246013 904591 Cj0266c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343708.1 245504 R 192222 CDS YP_002343709.1 218561930 904592 complement(246013..246543) 1 NC_002163.1 Original (2000) note: Cj0267c, probable integral membrane protein, len: 176 aa; no Hp match; Updated (2006) note: Two probable transmembrane helices identified by TMHMM2.0. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 246543 904592 Cj0267c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343709.1 246013 R 192222 CDS YP_002343710.1 218561931 904593 complement(246555..247643) 1 NC_002163.1 Original (2000) note: Cj0268c, probable transmembrane protein, len: 362 aa; 55.9% identity to HP0248. Contains one transmembrane domain around aa 60; Updated (2006) note: Pfam domain PF01145 SPFH domain / Band was identified within CDS. FPrintScan PR00679 Prohibitin was also identified. The FPrintScan identified is a child of the Pfam protein. No specific characherisation with acceptable identity scores have been carried out yet. kept within product function. Functional classification - Membranes, lipoproteins and porins; transmembrane protein 247643 904593 Cj0268c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transmembrane protein YP_002343710.1 246555 R 192222 CDS YP_002343711.1 218561932 904594 complement(247656..248570) 1 NC_002163.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 248570 ilvE 904594 ilvE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 branched-chain amino acid aminotransferase YP_002343711.1 247656 R 192222 CDS YP_002343712.1 218561933 904595 248747..248953 1 NC_002163.1 Original (2000) note: Cj0270, possible isomerase,len: 68 aa; some similarity hypothetical proteins and to to e.g. DMPI_PSESP 4-oxalocrotonate tautomerase (EC 5.3.2.-) ( (62 aa), fasta scores; opt: 91 z-score: 182.5 E(): 0.0066, 28.0% identity in 50 aa overlap, and XYLH_PSEPU 4-oxalocrotonate tautomerase (62 aa), fasta scores; opt: 86 z-score: 164.7 E(): 0.064, 25.8% identity in 62 aa overlap. No Hp ortholog, but 37.3% identity to HP0924. Also similar to Cj1255 (37.7% identity in 69 aa overlap); Updated (2006) note: Pfam domain PF01361 Tautomerase enzyme was identified within CDS. Product modified to more specific family member due to motif match. Some characterisation has been carried out within Pseudomonas species, however, identity scores were marginal. kept within product function. Functional classification - Misc; tautomerase family protein 248953 904595 Cj0270 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tautomerase family protein YP_002343712.1 248747 D 192222 CDS YP_002343713.1 218561934 904596 248950..249405 1 NC_002163.1 Original (2000) note: Cj0271, bacterioferritin comigratory protein homolog, len: 151 aa; similar to many e.g. BCP_ECOLI bacterioferritin comigratory protein (156 aa), fasta scores; opt: 390 z-score: 675.8 E(): 2.2e-30,39.6% identity in 149 aa overlap. 57.0% identity to HP0136. Contains Pfam match to entry PF00578 AhpC-TSA,AhpC/TSA family, score 146.30, E-value 5.4e-40; Updated (2006) note: Some characterisation work within Escherichia coli shows Cj0271 to be peroxiredoxin; bcp. Literature search also identified work within Helicobacter pylori. Product function kept the same. Functional classification - Misc; PMID:15618175, PMID:12576586, PMID:14506251; bacterioferritin comigratory protein 249405 904596 Cj0271 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bacterioferritin comigratory protein YP_002343713.1 248950 D 192222 CDS YP_002343714.1 218561935 904597 249405..250496 1 NC_002163.1 Original (2000) note: Cj0272, unknown, len: 363 aa; similar to hypothetical proteins e.g. TR:O66919 (EMBL:) Aquifex aeolicus AQ_701 (413 aa), fasta scores; opt: 830 z-score: 1296.8 E(): 0, 48.0% identity in 254 aa overlap. 37.4% identity to HP0100; Updated (2006) note: Pfam PF02677 Uncharacterized BCR was present within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 250496 904597 Cj0272 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343714.1 249405 D 192222 CDS YP_002343715.1 218561936 904598 250590..251030 1 NC_002163.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 251030 fabZ 904598 fabZ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 (3R)-hydroxymyristoyl-ACP dehydratase YP_002343715.1 250590 D 192222 CDS YP_002343716.1 218561937 904599 251030..251821 1 NC_002163.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 251821 lpxA 904599 lpxA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-N-acetylglucosamine acyltransferase YP_002343716.1 251030 D 192222 CDS YP_002343717.1 218561938 904600 251784..253037 1 NC_002163.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 253037 clpX 904600 clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP-dependent protease ATP-binding subunit ClpX YP_002343717.1 251784 D 192222 CDS YP_002343718.1 218561939 904601 253049..254089 1 NC_002163.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 254089 mreB 904601 mreB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 rod shape-determining protein MreB YP_002343718.1 253049 D 192222 CDS YP_002343719.1 218561940 904602 254079..254828 1 NC_002163.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 254828 mreC 904602 mreC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 rod shape-determining protein MreC YP_002343719.1 254079 D 192222 CDS YP_002343720.1 218561941 904603 255089..258358 1 NC_002163.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 258358 carB 904603 carB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 carbamoyl phosphate synthase large subunit YP_002343720.1 255089 D 192222 CDS YP_002343721.1 218561942 904604 258355..258777 1 NC_002163.1 Original (2000) note: Cj0280, unknown, len: 140 aa; 52.8% identity to HP0918. Functional classification -Conserved hypothetical proteins; hypothetical protein 258777 904604 Cj0280 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343721.1 258355 D 192222 CDS YP_002343722.1 218561943 904605 complement(258778..259755) 1 NC_002163.1 Important for the balance of metabolites in the pentose-phosphate pathway; transaldolase 259755 tal 904605 tal Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transaldolase YP_002343722.1 258778 R 192222 CDS YP_002343723.1 218561944 904606 complement(259755..260378) 1 NC_002163.1 Original (2000) note: Cj0282c, serB, possible phosphoserine phosphatase, len: 207 aa; similar to C-terminus of SERB_ECOLI phosphoserine phosphatase (EC 3.1.3.3) (322 aa), fasta scores; opt: 361 z-score: 572.4 E(): 1.3e-24, 34.3% identity in 204 aa overlap. 48.8% identity to HP0652; Updated (2006) note: Pfam domain PF00702 haloacid dehalogenase-like hydrolase were identified within CDS. TIGRFAM motif TIGR00338, serB phosphoserine phosphatase identified along with TIGR01488 HAD-SF-IB: HAD-superfamily hydrolase within CDS. Further support for product function. Characterised within Escherichia coli with acceptable identity scores, however, alignment was only partial. kept in product function. Functional classification - Amino acid biosynthesis - Serine family; PMID:2997734; phosphoserine phosphatase 260378 serB 904606 serB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoserine phosphatase YP_002343723.1 259755 R 192222 CDS YP_002343724.1 218561945 904607 complement(260378..260899) 1 NC_002163.1 Original (2000) note: Cj0283c, cheW, probable chemotaxis protein, len: 173 aa; similar to many e.g. CHEW_ECOLI purine-binding chemotaxis protein (167 aa),fasta scores; opt: 236 z-score: 304.4 E(): 1.1e-09, 32.4% identity in 139 aa overlap. 51.4% identity to HP0391; Updated (2006) note: Pfam domain PF01584 CheW-like domain identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score. not added to product function. Functional classification - Chemotaxis and mobility; PMID:2068106, PMID:3510184; chemotaxis protein 260899 cheW 904607 cheW Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 chemotaxis protein YP_002343724.1 260378 R 192222 CDS YP_002343725.1 218561946 904608 complement(260904..263213) 1 NC_002163.1 Original (2000) note: Cj0284c, cheA, probable chemotaxis histidine kinase, len: 769 aa; similar to many e.g. CHEA_ECOLI chemotaxis protein cheA (EC 2.7.3.-) (654 aa), fasta scores; opt: 1022 z-score: 1416.0 E(): 0, 35.7% identity in 658 aa overlap. 64.6% identity to HP0392. Contains Pfam matches to entry PF00072 response_reg,Response regulator receiver domain, score 103.80, E-value 3.4e-27 and to entry PF00512 signal, Signal carboxyl-terminal domain, score -12.30, E-value 0.00013; Updated (2006) note: Characterised within Escherichia coli with marginal identity scores. not added to product function. Functional classification -Chemotaxis and mobility; PMID:1938941, PMID:2068106; chemotaxis histidine kinase 263213 cheA 904608 cheA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 chemotaxis histidine kinase YP_002343725.1 260904 R 192222 CDS YP_002343726.1 218561947 904609 complement(263217..264173) 1 NC_002163.1 Original (2000) note: Cj0285c, cheV, probable chemotaxis protein cheV, len: 318 aa; similar to e.g. CHEV_BACSU chemotaxis cheV protein (EC 2.7.3.-) (303 aa),fasta scores; opt: 414 z-score: 344.9 E(): 5.9e-12, 28.2% identity in 309 aa overlap. 50.8% identity to HP0393. Contains Pfam match to entry PF00072 response_reg,Response regulator receiver domain, score 50.70, E-value 3.1e-11; Updated (2006) note: Pfam domain PF01584 CheW-like domain identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with marginal identity score. not added to product function. Functional classification - Chemotaxis and mobility; PMID:8169223, PMID:8169224; chemotaxis protein 264173 cheV 904609 cheV Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 chemotaxis protein YP_002343726.1 263217 R 192222 CDS YP_002343727.1 218561948 904610 complement(264166..264783) 1 NC_002163.1 Original (2000) note: Cj0286c, unknown, len: 205 aa; 28.4% identity to HP0394 (252 aa). Functional classification - Conserved hypothetical proteins; hypothetical protein 264783 904610 Cj0286c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343727.1 264166 R 192222 CDS YP_002343728.1 218561949 904611 complement(264934..265419) 1 NC_002163.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 265419 greA 904611 greA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcription elongation factor GreA YP_002343728.1 264934 R 192222 CDS YP_002343729.1 218561950 904612 complement(265431..266525) 1 NC_002163.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; ipid-A-disaccharide synthase 266525 lpxB 904612 lpxB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ipid-A-disaccharide synthase YP_002343729.1 265431 R 192222 CDS YP_002343730.1 218561951 904613 complement(266622..267374) 1 NC_002163.1 Original (2000) note: Cj0289c, peb3, major antigenic peptide PEB3, len: 250 aa; 94.9% identical to TR:G234575, sequenced by direct peptide sequencing; see: Pei at al. J. Biol. Chem. 266:16363-16369 (1991). Also similar to TR:Q57410 (EMBL:U39068) Vibrio cholerae accessory colonization factor acfC (253 aa), fasta scores; opt: 855 z-score: 1301.2 E(): 0, 53.6% identity in 239 aa overlap and TR:P96759 (EMBL:U82533) anm (E. coli 045 attachment and effacement negative mutant) (251 aa), fasta scores; opt: 849 z-score: 824.0 E(): 0, 51.8% identity in 251 aa overlap. No Hp match. Also similar to Cj0778 (peb2) (32.4% identity in 256 aa overlap). Contains N-terminal signal sequence; Updated (2006) note: Characterised within Campylobacter jejuni. Paper identified linking protein to glycoprotein (PMID:12186869). Functional classification -Miscellaneous periplasmic proteins; PMID:1885571, PMID:12186869; major antigenic peptide PEB3 267374 peb3 904613 peb3 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 major antigenic peptide PEB3 YP_002343730.1 266622 R 192222 CDS YP_002343731.1 218561952 904617 269064..269840 1 NC_002163.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 269840 surE 904617 surE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 stationary phase survival protein SurE YP_002343731.1 269064 D 192222 CDS YP_002343732.1 218561953 904618 269830..270489 1 NC_002163.1 Original (2000) note: Cj0294, unknown, len: 219 aa; similar to members of the hesA/moeB/thiF family, e.g. YGDL_ECOLI (268 aa), fasta scores; opt: 219 z-score: 563.3 E(): 4e-24, 33.5% identity in 254 aa overlap. 48.3% identity to HP0755 (described as moeB). Contains Pfam match to entry PF00899 ThiF_family, ThiF family, score 33.10, E-value 2e-07. Also similar to Cj1046c (33.6% identity in 146 aa overlap); Updated (2006) note: No specific characterisation with acceptable identity scores carried out yet. kept within product function. Functional classification -Misc; MoeB/ThiF family protein 270489 904618 Cj0294 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MoeB/ThiF family protein YP_002343732.1 269830 D 192222 CDS YP_002343733.1 218561954 904619 270473..270931 1 NC_002163.1 Original (2000) note: Cj0295, possible acetyltransferase, len: 152 aa; similar to hypothetical proteins e.g. YAFP_ECOLI (150 aa), fasta scores; opt: 246 z-score: 340.4 E(): 1.1e-11, 27.8% identity in 144 aa overlap. No Hp match. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 20.20, E-value 0.011; Updated (2006) note: Some characterisation within Escherichia coli with marginal identity score. kept within product function. Functional classification -Misc; acetyltransferase 270931 904619 Cj0295 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetyltransferase YP_002343733.1 270473 D 192222 CDS YP_002343734.1 218561955 904620 complement(271041..271421) 1 NC_002163.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 271421 panD 904620 panD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aspartate alpha-decarboxylase YP_002343734.1 271041 R 192222 CDS YP_002343735.1 218561956 904621 complement(271418..272266) 1 NC_002163.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 272266 panC 904621 panC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 pantoate--beta-alanine ligase YP_002343735.1 271418 R 192222 CDS YP_002343736.1 218561957 904622 complement(272277..273101) 1 NC_002163.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 273101 panB 904622 panB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_002343736.1 272277 R 192222 CDS YP_002343737.1 218561958 904623 273321..274094 1 NC_002163.1 Original (2000) note: Cj0299, possible periplasmic beta-lactamase, len: 257 aa; similar to members of the class-D beta-lactamase family e.g. BLL1_PSEAE BETA-LACTAMASE LCR-1 PRECURSOR (EC 3.5.2.6) (Pseudomonas aeruginosa plasmid PMG76) (260 aa), fasta scores; opt: 423 z-score: 305.2 E(): 9.6e-10, 33.7% identity in 255 aa overlap. No Hp match. Contains N-terminal signal sequence; Updated (2006) note: Some characterisation work within Pseudomonas aeruginosa and Escherichia coli with marginal identity scores. kept within product function. Functional classification - Antibiotic resistance; PMID:11188693, PMID:7574536; periplasmic beta-lactamase 274094 904623 Cj0299 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic beta-lactamase YP_002343737.1 273321 D 192222 CDS YP_002343738.1 218561959 904624 complement(274179..275063) 1 NC_002163.1 Original (2000) note: Cj0300c, modC, probable molybdenum transport ATP-binding protein, len: 294 aa; similar to many ABC-transporter ATP binding proteins, and to MODC_ECOLI molybdenum transport ATP-binding protein (352 aa), fasta scores; opt: 487 z-score: 700.9 E(): 8.7e-32, 34.8% identity in 270 aa overlap. Identification as modC is based on presence of probable molybdenum-specific permease and periplasmic binding proteins upstream. 46.8% identity to HP0475. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature and Pfam match to entry PF00005 ABC_tran, ABC transporters, score 214.40, E-value 1.7e-60; Updated (2006) note: Characterised more than once within Escherichia coli with marginal identity scores. kept within product function. Functional classification - Transport/binding proteins - Anions; PMID:2188958, PMID:7665461, PMID:7665460; molybdenum transport ATP-binding protein 275063 modC 904624 modC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molybdenum transport ATP-binding protein YP_002343738.1 274179 R 192222 CDS YP_002343739.1 218561960 904625 complement(275060..275734) 1 NC_002163.1 Original (2000) note: Cj0301c, modB, probable molybdenum transport system permease, len: 224 aa; similar to e.g. MODC_AZOVI molybdenum transport system permease (226 aa), fasta scores; opt: 562 z-score: 889.7 E(): 0, 43.3% identity in 210 aa overlap and MODB_ECOLI (229 aa), fasta scores; opt: 390 z-score: 537.4 E(): 1.1e-22, 32.8% identity in 183 aa overlap. 55.2% identity to HP0474. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 43.10, E-value 6.1e-09; Updated (2006) note: Characterised in many e.g. Rhodobacter capsulatus and Azotobacter vinelandii with acceptable identity scores. kept within product function. Functional classification - Transport/binding proteins - Anions; PMID:8384683, PMID:8491722; molybdenum transport system permease 275734 modB 904625 modB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molybdenum transport system permease YP_002343739.1 275060 R 192222 CDS YP_002343740.1 218561961 904626 complement(275727..276128) 1 NC_002163.1 Original (2000) note: Cj0302c, unknonw, len: 133 aa; no Hp match; Updated (2006) note: Pfam domain PF03459 TOBE domain identified within CDS. TOBE (Transport-associated OB) has had work carried out within Esherichia coli where it has been shown to be involved in the recognition of small ligands such as molybdenum. TOBE has been found in ABC transporters immediately after the ATPase domain. A child process of this family is Molybdenum-pterin binding protein. Product modified to more specific family member based on motif match. Some characterisation work within Clostridium pasteurianum, however, identity scores were marginal and full length sequence alignment was not achieved. Functional classification - Miscellaneous periplasmic proteins; PMID:3540853, PMID:2820842; molybdenum-pterin binding protein 276128 904626 Cj0302c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molybdenum-pterin binding protein YP_002343740.1 275727 R 192222 CDS YP_002343741.1 218561962 904627 complement(276125..276874) 1 NC_002163.1 Original (2000) note: Cj0303c, modA, probable molybdate-binding lipoprotein, len: 249 aa; similar to e.g. MODA_RHOCA molybdate-binding periplasmic protein precursor (252 aa), fasta scores; opt: 354 z-score: 449.0 E(): 9.4e-18, 30.8% identity in 224 aa overlap, and MODA_ECOLI (257 aa), fasta scores; opt: 220 z-score: 245.4 E(): 2.1e-06, 25.0% identity in 232 aa overlap. 42.3% identity to HP0473. Contains probable N-terminal signal sequence with appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Pfam domain PF01547 Bacterial extracellular solute-binding protein was identified within CDS. Further support given to product function. Characterised in more than one genus e.g. Rhodobacter capsulatus, Azotobacter vinelandii and Escherichia coli. Identity scores were marginal and sequence alignment was not full length. kept within product function. Functional classification - Transport/binding proteins -Anions; PMID:8491722, PMID:8384683, PMID:8564363; molybdate-binding lipoprotein 276874 modA 904627 modA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molybdate-binding lipoprotein YP_002343741.1 276125 R 192222 CDS YP_002343742.1 218561963 904628 complement(276925..277611) 1 NC_002163.1 Original (2000) note: Cj0304c, bioC, possible biotin synthesis protein, len: 228 aa; similar to BIOC_HAEIN biotin synthesis protein bioC (260 aa), fasta scores; opt: 342 z-score: 595.7 E(): 6.4e-26,34.0% identity in 238 aa overlap. Also some similarity to BIOC_ECOLI (251 aa), wublastp scores; E= 0.00028, 24% identity in 193 aa overlap. No Hp match; Updated (2006) note: Some characterisation within Bacillus subtilis and Escherichia coli, however, identity scores were unnacceptable. kept within product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Biotin; PMID:3058702, PMID:8763940; biotin synthesis protein 277611 bioC 904628 bioC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 biotin synthesis protein YP_002343742.1 276925 R 192222 CDS YP_002343743.1 218561964 904629 complement(277608..278219) 1 NC_002163.1 Original (2000) note: Cj0305c, unknown, len: 203 aa; similar to a hypothetical protein from H. infuenzae YF52_HAEIN HI1552 (215 aa), fasta scores; opt: 297 z-score: 372.7 E(): 1.7e-13, 29.8% identity in 215 aa overlap. No Hp match; Updated (2006) note: Pfam PF04301, Protein of unknown function (DUF452) was present within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 278219 904629 Cj0305c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343743.1 277608 R 192222 CDS YP_002343744.1 218561965 904630 complement(278216..279358) 1 NC_002163.1 Original (2000) note: Cj0306c, bioF, probable 8-amino-7-oxononanoate synthase, len: 380 aa; similar to many e.g. BIOF_ECOLI 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (384 aa), fasta scores; opt: 525 z-score: 550.3 E(): 2.1e-23, 28.9% identity in 387 aa overlap. 29.0% identity to HP0598. Contains PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site and Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, score 196.30, E-value 4.7e-55; Updated (2006) note: Characterised within Escherichia coli with marginal identity scores. not added to product function. Functional classification -Biosynthesis of cofactors, prosthetic groups and carriers - Biotin; PMID:9813126, PMID:1575677, PMID:1575677,PMID:3058702; 8-amino-7-oxononanoate synthase 279358 bioF 904630 bioF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 8-amino-7-oxononanoate synthase YP_002343744.1 278216 R 192222 CDS YP_002343745.1 218561966 904631 279426..280709 1 NC_002163.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 280709 bioA 904631 bioA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_002343745.1 279426 D 192222 CDS YP_002343746.1 218561967 904632 complement(280696..281301) 1 NC_002163.1 Original (2000) note: Cj0308c, bioD, possible dethiobiotin synthetase, len: 201 aa; some similarity to many e.g. BIOD_BACSH dethiobiotin synthetase (EC 6.3.3.3) (234 aa), fasta scores; opt: 206 z-score: 260.4 E(): 3e-07, 29.8% identity in 215 aa overlap. 31.8% identity in 66 aa overlap to HP0029; Updated (2006) note: Some characterisation within Bacillus sphaericus, however, identity score was marginal. kept within product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Biotin; PMID:2110099, PMID:3058702, PMID:10455485; dethiobiotin synthetase 281301 bioD 904632 bioD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dethiobiotin synthetase YP_002343746.1 280696 R 192222 CDS YP_002343747.1 218561968 904633 complement(281311..281625) 1 NC_002163.1 Original (2000) note: Cj0309c, probable efflux protein, len: 104 aa; similar to many membrane protein of known and unknown function e.g. TR:O34690 (EMBL:AJ002571) Bacillus subtilis YKKD (105 aa), fasta scores; opt: 303 z-score: 547.1 E(): 3.2e-23, 44.2% identity in 104 aa overlap, and EBR_STAAU ethidium bromide resistance protein (multidrug resistance protein) (107 aa), fasta scores; opt: 187 z-score: 272.5 E(): 6.4e-08, 27.2% identity in 103 aa overlap. No Hp match. Also similar to upstream CDS Cj0310c (32.4% identity in 105 aa overlap), and to Cj1174 (28.7% identity in 94 aa overlap) and Cj1173 (24.7% identity in 93 aa overlap). Contains Pfam match to entry PF00893 DUF7, Integral membrane protein, score 109.20,E-value 7.7e-29, and four possible transmembrane domains; Updated (2006) note: Pfam domain PF00893 Small Multidrug Resistance (Smr) protein identified within CDS. Previously this was an uncharacterised Pfam domain. Smr proteins are a family of efflux proteins that confer resistance to a wide range of toxic compounds by removing them from the cells. Further support given to product function. kept within product function. Functional classification - Drug/analogue sensitivity; PMID:10735877, PMID:11566977; efflux protein 281625 904633 Cj0309c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 efflux protein YP_002343747.1 281311 R 192222 CDS YP_002343748.1 218561969 904634 complement(281629..281967) 1 NC_002163.1 Original (2000) note: Cj0310c, possible efflux protein, len: 104 aa; similar to many membrane proteins of known and unknown function e.g. YKKC_BACSU (112 aa), fasta scores; opt: 273 z-score: 458.2 E(): 2.9e-18, 40.8% identity in 103 aa overlap, and EBR_STAAU ethidium bromide resistance protein (107 aa), fasta scores; opt: 135 z-score: 198.9 E(): 0.00088, 27.4% identity in 84 aa overlap. No Hp match. Also similar to downstream CDS Cj0309c (32.4% identity in 105 aa overlap) and to Cj1173 (27.1% identity in 107 aa overlap). Contains Pfam match to entry PF00893 DUF7, Integral membrane protein, score 51.40, E-value 2e-11, and four possible transmembrane domains; Updated (2006) note: Pfam domain PF00893 Small Multidrug Resistance (Smr family) protein identified within CDS. Previously this was an uncharacterised Pfam domain. Smr proteins are a family of efflux proteins that confer resistance to a wide range of toxic compounds by removing them from the cells. Further support given to product function. kept within product function. Functional classification - Drug/analogue sensitivity; PMID:10735877, PMID:11948170; efflux protein 281967 904634 Cj0310c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 efflux protein YP_002343748.1 281629 R 192222 CDS YP_002343749.1 218561970 904635 282101..282637 1 NC_002163.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 282637 904635 Cj0311 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L25 YP_002343749.1 282101 D 192222 CDS YP_002343750.1 218561971 904636 282634..283179 1 NC_002163.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 283179 pth 904636 pth Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptidyl-tRNA hydrolase YP_002343750.1 282634 D 192222 CDS YP_002343751.1 218561972 904637 283181..284239 1 NC_002163.1 Original (2000) note: Cj0313, probable integral membrane protein, len: 352 aa; 35.9% identity to HP1498; Updated (2006) note: Pfam domains PF03739 Predicted permease YjgP/YjgQ family were identified. Members of this family are predicted integral membrane proteins of unknown function. They are about 350 amino acids long and contain about 6 transmembrane regions. They are predicted to be permeases although there is no verification of this. Six probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 284239 904637 Cj0313 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343751.1 283181 D 192222 CDS YP_002343752.1 218561973 904638 284283..285491 1 NC_002163.1 Original (2000) note: Cj0314, lysA, probable diaminopimelate decarboxylase, len: 402 aa; highly similar to mnay e.g. DCDA_PSEAE diaminopimelate decarboxylase (EC 4.1.1.20) (415 aa), fasta scores; opt: 1077 z-score: 968.8 E(): 0, 44.7% identity in 394 aa overlap. 60.4% identity to HP0290. Contains Pfam match to entry PF00278 Orn_DAP_Arg_deC, Pyridoxal-dependent decarboxylase, score 381.60, E-value 2.3e-113; Updated (2006) note: Characterised within Pseudomonas aeruginosa with acceptable identity score. not added to product function. Functional classification - Amino acid biosynthesis - Aspartate family; PMID:3143046; diaminopimelate decarboxylase 285491 lysA 904638 lysA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 diaminopimelate decarboxylase YP_002343752.1 284283 D 192222 CDS YP_002343753.1 218561974 904639 285493..286260 1 NC_002163.1 Original (2000) note: Cj0315, unknown, len: 255 aa; similar to the hypothetical proteins TR:O59622 (EMBL:AB009530) Pyrococcus horikoshii PHBR011 (263 aa),fasta scores; opt: 185 z-score: 375.5 E(): 1.2e-13, 28.1% identity in 267 aa overlapNAGD_ECOLI nagD protein (250 aa), fasta scores; opt: 259 z-score: 266.1 E(): 1.4e-07,26.0% identity in 250 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF00702 haloacid dehalogenase-like hydrolase, PF02142 MGS-like domain and PF03558 TBSV core protein P21/P22 were identified with separate Pfam search. This family is a member of the HAD superfamily which includes L-2-haloacid dehalogenase,epoxide hydrolases and phosphatases. Previous matches to nagD protein are also members of this family. Product function modified to more specific family member based on motif match. No specific characterisation has been carried out yet. kept within product function. Functional classification - Misc; HAD-superfamily hydrolase 286260 904639 Cj0315 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 HAD-superfamily hydrolase YP_002343753.1 285493 D 192222 CDS YP_002343754.1 218561975 904640 286248..287321 1 NC_002163.1 Original (2000) note: Cj0316, pheA, probable chorismate mutase/prephenate dehydratase, len: 357 aa; similar to many e.g. PHEA_ECOLI chorismate mutase (EC 5.4.99.5)/prephenate dehydratase (EC 4.2.1.51) (386 aa),fasta scores; opt: 482 z-score: 733.8 E(): 0, 33.1% identity in 366 aa overlap. Similar in N-term to possible truncated pheA in Hp; HP0291 hypothetical protein (96 aa) 35.8% identity in 81 aa overlap. Contains PS00857 and PS00858 Prephenate dehydratase signatures 1 and 2, and Pfam match to entry PF00800 PDT, Prephenate dehydratase,score 268.20, E-value 1.1e-76; Updated (2006) note: Pfam domains PF01817 Chorismate mutase type II and PF01842 ACT domainn were identified. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification - Amino acid biosynthesis -Aromatic amino acid family; PMID:9497350; chorismate mutase/prephenate dehydratase 287321 pheA 904640 pheA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 chorismate mutase/prephenate dehydratase YP_002343754.1 286248 D 192222 CDS YP_002343755.1 218561976 904641 287311..288405 1 NC_002163.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 288405 hisC 904641 hisC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 histidinol-phosphate aminotransferase YP_002343755.1 287311 D 192222 CDS YP_002343756.1 218561977 904642 288457..290139 1 NC_002163.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 290139 fliF 904642 fliF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar MS-ring protein YP_002343756.1 288457 D 192222 CDS YP_002343757.1 218561978 904643 290139..291167 1 NC_002163.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 291167 fliG 904643 fliG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar motor switch protein G YP_002343757.1 290139 D 192222 CDS YP_002343758.1 218561979 904644 291175..292005 1 NC_002163.1 binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 292005 fliH 904644 fliH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar assembly protein H YP_002343758.1 291175 D 192222 CDS YP_002343759.1 218561980 904645 291998..293845 1 NC_002163.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 293845 dxs 904645 dxs Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 1-deoxy-D-xylulose-5-phosphate synthase YP_002343759.1 291998 D 192222 CDS YP_002343760.1 218561981 904646 293931..294341 1 NC_002163.1 Original (2000) note: Cj0322, perR, regulator of peroxide stress regulon, len: 136 aa; similar to many members of the furR family e.g. FUR3_BACSU ferric uptake regulation protein homolog 3 (145 aa), fasta scores; opt: 258 z-score: 379.6 E(): 6.9e-14, 32.6% identity in 135 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF01475 Ferric uptake regulator family was identified within CDS. Further support given to product function. Marginal identity scores were obtained with many. Appropriate motifs present. not added to product function. Functional classification - Broad regulatory functions; PMID:9701813, PMID:12100544; peroxide stress regulator 294341 perR 904646 perR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peroxide stress regulator YP_002343760.1 293931 D 192222 CDS YP_002343761.1 218561982 904647 294387..295583 1 NC_002163.1 Original (2000) note: Cj0323, unknown, len: 398 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 295583 904647 Cj0323 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343761.1 294387 D 192222 CDS YP_002343762.1 218561983 904648 295586..296293 1 NC_002163.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 296293 ubiE 904648 ubiE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ubiquinone/menaquinone biosynthesis methyltransferase YP_002343762.1 295586 D 192222 CDS YP_002343763.1 218561984 904649 296290..297453 1 NC_002163.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 297453 xseA 904649 xseA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 exodeoxyribonuclease VII large subunit YP_002343763.1 296290 D 192222 CDS YP_002343764.1 218561985 904650 297463..298539 1 NC_002163.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 298539 serC 904650 serC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoserine aminotransferase YP_002343764.1 297463 D 192222 CDS YP_002343765.1 218561986 904651 298536..298886 1 NC_002163.1 Original (2000) note: Cj0327, unknown, len: 116 aa; similar to hypothetical proteins e.g. YABJ_BACSU (125 aa),fasta scores; opt: 211 z-score: 261.9 E(): 2.5e-07, 33.0% identity in 109 aa overlap, and to e.g. UK14_HUMAN 14.5 kd translational inhibitor protein (137 aa), fasta scores; opt: 173 z-score: 249.5 E(): 1.2e-06, 29.2% identity in 106 aa overlap. No Hp ortholog. Also similar to Cj1388 (33.3% identity in 96 aa overlap). Contains Pfam match to entry PF01042 DUF10, Domain of unknown function, score 69.30, E-value 8.4e-17; Updated (2006) note: Pfam domain PF01042 Endoribonuclease L-PSP identified within CDS (previously uncharacterised). Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet. kept within product fucntion. Functional classification - Degradation of macromolecules - DNA; endoribonuclease L-PSP family protein 298886 904651 Cj0327 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 endoribonuclease L-PSP family protein YP_002343765.1 298536 D 192222 CDS YP_002343766.1 218561987 904652 complement(298883..299857) 1 NC_002163.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 299857 fabH 904652 fabH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 3-oxoacyl-ACP synthase YP_002343766.1 298883 R 192222 CDS YP_002343767.1 218561988 904653 complement(299850..300836) 1 NC_002163.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 300836 plsX 904653 plsX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glycerol-3-phosphate acyltransferase PlsX YP_002343767.1 299850 R 192222 CDS YP_002343768.1 218561989 904654 complement(300842..300988) 1 NC_002163.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 300988 rpmF 904654 rpmF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L32 YP_002343768.1 300842 R 192222 CDS YP_002343769.1 218561990 904655 complement(301012..301365) 1 NC_002163.1 Original (2000) note: Cj0331c, unknown, len: 117 aa; 34.7% identity to HP0199. Functional classification -Conserved hypothetical proteins; hypothetical protein 301365 904655 Cj0331c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343769.1 301012 R 192222 CDS YP_002343770.1 218561991 904656 complement(301366..301779) 1 NC_002163.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 301779 ndk 904656 ndk Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 nucleoside diphosphate kinase YP_002343770.1 301366 R 192222 CDS YP_002343771.1 218561992 904657 complement(301892..302176) 1 NC_002163.1 Original (2000) note: Cj0333c, fdxA, probable ferredoxin, len: 94 aa; similar to many e.g. FER_CLOTM ferredoxin (55 aa), fasta scores; opt: 142 z-score: 311.2 E(): 4.5e-10, 45.8% identity in 59 aa overlap. No Hp ortholog. Also similar to Cj0354c (38.8% identity in 67 aa overlap). Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains., score 51.80, E-value 8.8e-14; Updated (2006) note: Similar to many e.g. Clostridium sp. with acceptable identity scores. not added to product function. Functional classification -Energy metabolism - Electron transport; PMID:4433520; ferredoxin 302176 fdxA 904657 fdxA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ferredoxin YP_002343771.1 301892 R 192222 CDS YP_002343772.1 218561993 904658 302383..302979 1 NC_002163.1 Original (2000) note: Cj0334, ahpC, probable alkyl hydroperoxide reductase, len: 198 aa; highly simlar to e.g. TDX1_HUMAN thioredoxin peroxidase 1 (198 aa), fasta scores; opt: 615 z-score: 915.3 E(): 0, 46.1% identity in 193 aa overlap, and to e.g. AHPC_ECOLI P26427 alkyl hydroperoxide reductase C22 protein (EC 1.6.4.-) (186 aa),wublastp scores E= 8.9e-23, 34% identity in 149 aa overlap. 67.7% identity to HP1563 (Hp 26 kD antigen). Contains Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family, score 208.20, E-value 1.2e-58; Updated (2006) note: Characterised within Campylobacter jejuni. not added to product function. Literature search identified paper linking protein to glycoprotein (PMID:12186869). Functional classification - Detoxification; PMID:10438747, PMID:10515927, PMID:12186869; alkyl hydroperoxide reductase 302979 ahpC 904658 ahpC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 alkyl hydroperoxide reductase YP_002343772.1 302383 D 192222 CDS YP_002343773.1 218561994 904659 303098..304186 1 NC_002163.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 304186 flhB 904659 flhB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar biosynthesis protein FlhB YP_002343773.1 303098 D 192222 CDS YP_002343774.1 218561995 904660 complement(304192..304935) 1 NC_002163.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 304935 motB 904660 motB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar motor protein MotB YP_002343774.1 304192 R 192222 CDS YP_002343775.1 218561996 904661 complement(304938..305714) 1 NC_002163.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 305714 motA 904661 motA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar motor protein MotA YP_002343775.1 304938 R 192222 CDS YP_002343776.1 218561997 904662 complement(305730..308369) 1 NC_002163.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 308369 polA 904662 polA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA polymerase I YP_002343776.1 305730 R 192222 CDS YP_002343777.1 218561998 904663 308533..309894 1 NC_002163.1 Original (2000) note: Cj0339, probable transmembrane transport protein, len: 453 aa; similar to e.g. YDFJ_ECOLI hypothetical metabolite transport protein (427 aa), fasta scores; opt: 1214 z-score: 1428.6 E(): 0,42.5% identity in 416 aa overlap, and SHIA_ECOLI shikimate transporter (438 aa), fasta scores; opt: 876 z-score: 1104.0 E(): 0, 32.3% identity in 421 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00083 sugar_tr,Sugar (and other) transporters, score 123.20, E-value 4.9e-33; Updated (2006) note: Ten probable transmembrace helices identified by TMHMM2.0 within CDS. Pfam domain PF07690 Major Facilitator Superfamily protein identified within CDS. Prosite PS50850 MFS, Major facilitator superfamily also identifed within CDS. Product modified to new family member based on motif match. No specific characterisation has been carried out yet. kept within product function. Functional classification -Transport/binding proteins - Other; PMID:15919996; MFS transport protein 309894 904663 Cj0339 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MFS transport protein YP_002343777.1 308533 D 192222 CDS YP_002343778.1 218561999 904664 309891..310898 1 NC_002163.1 Original (2000) note: Cj0340, possible nucleoside hydrolase, len: 335 aa; similar to hypothetical proteins e.g. YAAF_ECOLI (304 aa), fasta scores; opt: 252 z-score: 377.2 E(): 9.4e-14, 25.9% identity in 309 aa overlap, and to the eukaryotic IUNH_CRIFA inosine-uridine preferring nucleoside hydrolase (314 aa), fasta scores; opt: 261 z-score: 363.4 E(): 5.5e-13, 25.3% identity in 296 aa overlap. No Hp match. Contains Pfam match to entry PF01156 IU_nuc_hydro, Inosine-uridine preferring nucleoside hydrolase, score -11.20, E-value 4.8e-12; Updated (2006) note: No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Salvage of nucleosides and nucleotides; PMID:10409664; nucleoside hydrolase 310898 904664 Cj0340 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 nucleoside hydrolase YP_002343778.1 309891 D 192222 CDS YP_002343779.1 218562000 904665 complement(310854..311297) 1 NC_002163.1 Original (2000) note: Cj0341c, possible integral membrane protein, len: 147 aa; similar to hypothetical membrane proteins e.g. Y489_HAEIN HI0489 (157 aa), fasta scores; opt: 252 z-score: 350.5 E(): 2.9e-12, 34.0% identity in 159 aa overlap. No Hp match; Updated (2006) note: Four probable transmembrace helices identified by TMHMM2.0 within CDS. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 311297 904665 Cj0341c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343779.1 310854 R 192222 CDS YP_002343780.1 218562001 904666 complement(311302..314127) 1 NC_002163.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 314127 uvrA 904666 uvrA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 excinuclease ABC subunit A YP_002343780.1 311302 R 192222 CDS YP_002343781.1 218562002 904667 complement(314200..314985) 1 NC_002163.1 Original (2000) note: Cj0343c, probable integral membrane protein, len: 261 aa; similar to many hypothetical membrane proteins e.g. Y441_METJA MJ0441 (267 aa), fasta scores; opt: 152 z-score: 301.8 E(): 1.5e-09,30.7% identity in 257 aa overlap. 45.1% identity to HP0677 and 44.0% identity to HP0226; Updated (2006) note: Nine probable transmembrace helices identified by TMHMM2.0 within CDS. Pfam PF01925 Domain of unknown function (DUF81) protein identified within CDS. Further support given to product function. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 314985 904667 Cj0343c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343781.1 314200 R 192222 CDS YP_002343782.1 218562003 904668 315108..315233 1 NC_002163.1 Original (2000) note: Cj0344, unknown, len: 41 aa; no Hp match. Functional classification - Unknown; hypothetical protein 315233 904668 Cj0344 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343782.1 315108 D 192222 CDS YP_002343783.1 218562004 904669 315398..316648 1 NC_002163.1 Original (2000) note: Cj0345, trpE, possible anthranilate synthase component I, len: 416 aa; similar in C-terminal half to many e.g. TRPE_CLOTM anthranilate synthase component I (EC 4.1.3.27) (494 aa), fasta scores; opt: 784 z-score: 1209.9 E(): 0, 47.0% identity in 281 aa overlap. 35.6% identity in 365 aa overlap to HP1282. Contains Pfam match to entry PF00425 chorismate_bind,chorismate binding enzyme, score 309.50, E-value 3.9e-89; Updated (2006) note: Characterised within Clostridium thermocellum with acceptable identity score,however, sequence alignment was only partial. Thus, kept within product function. Functional classification - Amino acid biosynthesis - Aromatic amino acid family; PMID:2732211, PMID:789357; anthranilate synthase component I 316648 trpE 904669 trpE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 anthranilate synthase component I YP_002343783.1 315398 D 192222 CDS YP_002343784.1 218562005 904670 316645..318246 1 NC_002163.1 Original (2000) note: Cj0346, trpD (trpGD),probable anthranilate synthase component II, len: 533 aa; (contains glutamine amidotransferase and anthranilate phosphoribosyltransferase) similar to many e.g. TRPG_ECOLI anthranilate synthase component II (EC 4.1.3.27) (530 aa),fasta scores; opt: 866 z-score: 781.3 E(): 0, 32.6% identity in 528 aa overlap. N-terminus has 34.6% identity to HP1281, C-terminus is 33.2% identity to HP1280. Contains PS00442 Glutamine amidotransferases class-I active site and Pfam matches to entry PF00117 GATase,Glutamine amidotransferases class-I, score 252.00, E-value 8.4e-72 and to entry PF00591 Glycos_transf_3, glycosyl transferase family, score 138.60, E-value 1.1e-37; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Amino acid biosynthesis - Aromatic amino acid family; PMID:6283099, PMID:4594441, PMID:789357; anthranilate synthase component II 318246 trpD 904670 trpD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 anthranilate synthase component II YP_002343784.1 316645 D 192222 CDS YP_002343785.1 218562006 904671 318233..318832 1 NC_002163.1 Original (2000) note: Cj0347, trpF, probable N-(5'-phosphoribosyl)anthranilate isomerase, len: 199 aa; similar to many trpF e.g. TRPF_LACCA N-(5'-phosphoribosyl)anthranilate isomerase (199 aa) (EC 5.3.1.24), fasta scores; opt: 271 z-score: 352.4 E(): 2.3e-12, 31.0% identity in 200 aa overlap, and to the trpF domain of many trpC proteins e.g. TRPC_SALTY indole-3-glycerol phosphate synthase, fasta scores; opt: 307 z-score: 394.5 E(): 1e-14, 30.8% identity in 201 aa overlap. 38.2% identity to C-terminus of HP1279 (trpC) Conatains Pfam match to entry PF00697 PRAI,N-(5'phosphoribosyl)antranilate (PRA) isomerase, score 102.30, E-value 9.5e-27; Updated (2006) note: Search results match to more than one isomerase with marginal identity scores. not added to product function. Functional classification -Amino acid biosynthesis - Aromatic amino acid family; PMID:2299982, PMID:2184433, PMID:789357; N-(5'-phosphoribosyl)anthranilate isomerase 318832 trpF 904671 trpF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 N-(5'-phosphoribosyl)anthranilate isomerase YP_002343785.1 318233 D 192222 CDS YP_002343786.1 218562007 904672 318829..320007 1 NC_002163.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 320007 trpB 904672 trpB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tryptophan synthase subunit beta YP_002343786.1 318829 D 192222 CDS YP_002343787.1 218562008 904673 320000..320749 1 NC_002163.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 320749 trpA 904673 trpA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tryptophan synthase subunit alpha YP_002343787.1 320000 D 192222 CDS YP_002343788.1 218562009 904674 320820..321242 1 NC_002163.1 Original (2000) note: Cj0350, unknown, len: 140 aa; no Hp match. . Functional classification - Unknown; hypothetical protein 321242 904674 Cj0350 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343788.1 320820 D 192222 CDS YP_002343789.1 218562010 904675 321242..321550 1 NC_002163.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein 321550 fliN 904675 fliN Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar motor switch protein YP_002343789.1 321242 D 192222 CDS YP_002343790.1 218562011 904676 321551..322348 1 NC_002163.1 Original (2000) note: Cj0352, probable transmembrane protein, len: 265 aa; 99.6% identity to TR:O32371 (EMBL:AJ000400). No Hp match. Contains probable N-terminal signal sequence and transmembrane domain around aa 160; Updated (2006) note: Two probable transmembrane helices identified by TMHMM2.0 within CDS. Literature search identified paper linking CDS with potential new functional assignment as FliO flagellar protein. Functional classification - Membranes, lipoproteins and porins; PMID:15817382, PMID:9894591; transmembrane protein 322348 904676 Cj0352 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transmembrane protein YP_002343790.1 321551 D 192222 CDS YP_002343791.1 218562012 904677 complement(322345..323805) 1 NC_002163.1 Original (2000) note: Cj0353c, probable phosphatase, len: 486 aa; similar to e.g. GPPA_ECOLI guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC 3.6.1.40) (494 aa), fasta scores; opt: 368 z-score: 272.7 E(): 6.2e-08, 25.8% identity in 480 aa overlap, and to PPX_ECOLI EXOPOLYPHOSPHATASE (EC 3.6.1.11) (512 aa),fasta scores; opt: 340 z-score: 350.9 E(): 2.7e-12, 23.8% identity in 441 aa overlap. 41.0% identity to HP0278; Updated (2006) note: Pfam domain PF02541 Ppx/GppA phosphatase family identified within CDS. Further support given to product function. Similar to many different annotated phosphatases. not added to product function. Functional classification - Misc; PMID:8394006; phosphatase 323805 904677 Cj0353c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphatase YP_002343791.1 322345 R 192222 CDS YP_002343792.1 218562013 904678 complement(323805..324050) 1 NC_002163.1 Original (2000) note: Cj0354c, fdxB, probable ferredoxin, len: 81 aa; similar to many e.g. FER_CHRVI ferredoxin (82 aa), fasta scores; opt: 282 z-score: 445.5 E(): 1.5e-17, 45.3% identity in 75 aa overlap. 58.4% identity to HP0277. Also similar to Cj0333c (fdx); 38.8% identity in 67 aa overlap. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains., score 39.00,E-value 4.8e-10; Updated (2006) note: Characterised within Chromatium vinosum with acceptable identity scores. Appropriate motifs also present. not added to product function. Functional classification - Energy metabolism - Electron transport; PMID:8765743; ferredoxin 324050 fdxB 904678 fdxB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ferredoxin YP_002343792.1 323805 R 192222 CDS YP_002343793.1 218562014 904679 complement(324163..324834) 1 NC_002163.1 Original (2000) note: Cj0355c, probable two-component regulator, len: 223 aa; similar to many e.g. CZCR_ALCEU transcriptional activator protein CZCR (225 aa), fasta scores; opt: 375 z-score: 570.8 E(): 1.5e-24,31.7% identity in 218 aa overlap. 59.9% identity to HP1043. Contains Pfam match to entry PF00072 response_reg,Response regulator receiver domain, score 70.70, E-value 3.1e-17 and Pfam match to entry PF00486 trans_reg_C,Transcriptional regulatory protein, C terminal, score 56.60, E-value 1.5e-15; Updated (2006) note: Characterisation work within many e.g. Ralstonia metallidurans and Escherichia coli with marginal identity scores. Appropriate motifs also present. not added to product function. Literature search identified paper giving further clues to product function (PMID:15901688). Functional classification - Signal transduction; PMID:9044283, PMID:15901688; two-component regulator 324834 904679 Cj0355c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 two-component regulator YP_002343793.1 324163 R 192222 CDS YP_002343794.1 218562015 904680 complement(324913..325230) 1 NC_002163.1 Original (2000) note: Cj0356c, unknown, len: 105 aa; 31.0% identity to HP1510; Updated (2006) note: Pfam domain PF02152 FolB Dihydroneopterin aldolase was identified within CDS. This enzyme catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate. This was found by carrying out own Pfam search. Product modified to new family member due to motif match. No specific characterisation has been carried out yet. kept within product function. Functional classification - Misc; dihydroneopterin aldolase 325230 folB 904680 folB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dihydroneopterin aldolase YP_002343794.1 324913 R 192222 CDS YP_002343795.1 218562016 904681 complement(325215..325823) 1 NC_002163.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 325823 904681 Cj0357c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glycerol-3-phosphate acyltransferase PlsY YP_002343795.1 325215 R 192222 CDS YP_002343796.1 218562017 904682 326024..327049 1 NC_002163.1 Original (2000) note: Cj0358, probable cytochrome C551 peroxidase, len: 341 aa; similar to e.g. CCPR_PSEAE cytochrome C551 peroxidase precursor (EC 1.11.1.5) (346 aa), fasta scores; opt: 281 z-score: 1028.0 E(): 0, 48.9% identity in 313 aa overlap. 58.5% identity to HP1461. Also similar to Cj0020c (45.4% identity in 273 aa overlap). Contains 2x PS00190 Cytochrome c family heme-binding site signature and probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF03150 Di-haem cytochrome c peroxidase identified within CDS. Further support given to product function. Characterised within Pseudomonas aeruginosa with acceptable identity score,however, only partial sequence alignment was achieved. kept within product function. Functional classification - Detoxification; PMID:7781769, PMID:8591033; cytochrome C551 peroxidase 327049 904682 Cj0358 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytochrome C551 peroxidase YP_002343796.1 326024 D 192222 CDS YP_002343797.1 218562018 904683 327143..328480 1 NC_002163.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 328480 glmM 904683 glmM Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoglucosamine mutase YP_002343797.1 327143 D 192222 CDS YP_002343798.1 218562019 904684 328473..328943 1 NC_002163.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 328943 lspA 904684 lspA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein signal peptidase YP_002343798.1 328473 D 192222 CDS YP_002343799.1 218562020 904685 328927..329379 1 NC_002163.1 Original (2000) note: Cj0362, probable integral membrane protein, len: 150 aa; similar to hypothetical proteins e.g. TR:Q53231 (EMBL:L76097) from Rhodobacter sphaeroides (154 aa), fasta scores; opt: 301 z-score: 419.6 E(): 4.1e-16, 34.2% identity in 149 aa overlap. 47.6% identity to HP1484; Updated (2006) note: Four probable transmembrace helices identified by TMHMM2.0 within CDS. Pfam domain PF03653 Uncharacterised protein family (UPF0093) identified within CDS. Further support given to product function. Functional classification - Membranes,lipoproteins and porins; integral membrane protein 329379 904685 Cj0362 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343799.1 328927 D 192222 CDS YP_002343800.1 218562021 904686 complement(329376..330722) 1 NC_002163.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 330722 904686 Cj0363c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 coproporphyrinogen III oxidase YP_002343800.1 329376 R 192222 CDS YP_002343801.1 218562022 904687 330851..331102 1 NC_002163.1 Original (2000) note: Cj0364, unknown, len: 83 aa; no Hp match; Updated (2006) note: Literature search identified paper giving further clues to product function. Functional classification - Unknown; hypothetical protein 331102 904687 Cj0364 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343801.1 330851 D 192222 CDS YP_002343802.1 218562023 904688 complement(331125..332603) 1 NC_002163.1 Original (2000) note: Cj0365c, possible outer membrane channel protein, len: 492 aa; similar to members of the nodT/fusA family e.g. TR:O31101 (EMBL:AF029405) Pseudomonas putida outer membrane channel protein SRPC (470 aa), fasta scores; opt: 645 z-score: 834.4 E(): 0,29.2% identity in 465 aa overlap. and TR:Q51006 (EMBL:X95635) Neisseria gonorrhoeae mtrE gene (467 aa,fasta scores; opt: 663 z-score: 829.8 E(): 0, 31.1% identity in 476 aa overlap. No Hp match. Also some similarity to Cj0608 (28.6% identity in 455 aa overlap). Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Pfam domains x2 PF02321 Outer membrane efflux proteins were identified within CDS. Further support given to product function. Characterised within Campylobacter jejuni. Part of the CmeABC multidrug efflux system. Functional classification - Antibiotic resistance; PMID:12069964, PMID:15728904, PMID:16359189; outer membrane channel protein CmeC 332603 cmeC 904688 cmeC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 outer membrane channel protein CmeC YP_002343802.1 331125 R 192222 CDS YP_002343803.1 218562024 904689 complement(332596..335718) 1 NC_002163.1 Original (2000) note: Cj0366c, probable transmembrane efflux protein, len: 1040 aa; similar to e.g. TR:P95422 (EMBL:X99514) Pseudomonas aeruginosa mexF (antibiotic efflux system protein) (1062 aa), fasta scores; opt: 1584 z-score: 3208.4 E(): 0, 41.2% identity in 1056 aa overlap, and ACRB_ECOLI acriflavin resistance protein B (1049 aa), fasta scores; opt: 2739 z-score: 3055.6 E(): 0, 41.7% identity in 1031 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00873 ACR_tran,AcrB/AcrD/AcrF family, score 1415.10, E-value 0; Updated (2006) note: Thirteen probable transmembrace helices identified by TMHMM2.0 within CDS. Prosite domain PS50156 SSD, Sterol-sensing 5TM box also identified within CDS. Further support given to product function. Characterised within Campylobacter jejuni. Part of the CmeABC multidrug efflux system. Functional classification - Antibiotic resistance; PMID:12069964, PMID:11814661, PMID:15728904,PMID:16359189, PMID:15201231; inner membrane efflux transporter CmeB 335718 cmeB 904689 cmeB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 inner membrane efflux transporter CmeB YP_002343803.1 332596 R 192222 CDS YP_002343804.1 218562025 904690 complement(335718..336821) 1 NC_002163.1 Original (2000) note: Cj0367c, possible membrane fusion component of efflux system, len: 367 aa; similar to e.g. MTRC_NEIGO membrane fusion protein MTRC precursor (412 aa), fasta scores; opt: 592 z-score: 692.4 E(): 2.6e-31, 29.9% identity in 358 aa overlap, and TR:P95421 (EMBL:X99514) Pseudomonas aeruginosa mexE (antibiotic efflux system protein) (414 aa), fasta scores; opt: 460 z-score: 570.0 E(): 1.7e-24, 26.9% identity in 357 aa overlap. No Hp ortholog. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Pfam domain PF00529 HlyD family secretion protein identified within CDS. Further support given to product function. Part of the CmeABC multidrug efflux system. Functional classification -Antibiotic resistance; PMID:12069964, PMID:15728904, PMID:16359189; periplasmic fusion protein CmeA 336821 cmeA 904690 cmeA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic fusion protein CmeA YP_002343804.1 335718 R 192222 CDS YP_002343805.1 218562026 904691 complement(336916..337548) 1 NC_002163.1 Original (2000) note: Cj0368c, probable transcriptional regulatory protein, len: 210 aa; similar to members of the tetR family e.g. TR:G3327947 (EMBL:AF053772) Staphylococcus aureus transcriptional regulator qacR (regulator of multidrug efflux protein QacB) (188 aa), fasta scores; opt: 162 z-score: 285.0 E(): 1.3e-08, 29.3% identity in 198 aa overlap, and MTRR_NEIGO regulatory protein MTRR (210 aa), fasta scores; opt: 137 z-score: 210.6 E(): 0.00018, 31.3% identity in 83 aa overlap. No Hp match. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 24.00, E-value 6.4e-05; Updated (2006) note: Characterised within Campylobacter jejuni. Product function modified to more speicific family member. Characterisation paper shows that CmeR is a transcriptional repressor for the downstream CmeABC operon. Functional classification - Broad regulatory functions; PMID:15728904; transcriptional regulator CmeR 337548 cmeR 904691 cmeR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcriptional regulator CmeR YP_002343805.1 336916 R 192222 CDS YP_002343806.1 218562027 904692 complement(337535..338911) 1 NC_002163.1 Original (2000) note: Cj0369c, ferredoxin domain-containing integral membrane protein, len: 458 aa; some similarity to e.g. RDXA_RHOSH RDXA protein (469 aa),fasta scores; opt: 474 z-score: 657.7 E(): 2.2e-29, 24.9% identity in 402 aa overlap, and FIXG_RHIME nitrogen fixation protein FIXG (524 aa), fasta scores; opt: 476 z-score: 533.8 E(): 1.8e-22, 28.7% identity in 296 aa overlap. 45.7% identity to HP1508. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains., score 17.10,E-value 0.0011; Updated (2006) note: Five probable transmembrace helices identified by TMHMM2.0 within CDS. Further support given to product function. No specific characterisation with acceptable identity scores identified yet. kept within product function. Functional classification -Energy metabolism - Electron transport; ferredoxin domain-containing integral membrane protein 338911 904692 Cj0369c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ferredoxin domain-containing integral membrane protein YP_002343806.1 337535 R 192222 CDS YP_002343807.1 218562028 904693 339071..339283 1 NC_002163.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 339283 rpsU 904693 rpsU Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S21 YP_002343807.1 339071 D 192222 CDS YP_002343808.1 218562029 904694 339403..340008 1 NC_002163.1 Original (2000) note: Cj0371, probable lipoprotein,len: 201 aa; similar to H. pylori gene fragment reported to be involved in flagellar motility TR:Q48273 (EMBL:Z68311) (122 aa), fasta scores; opt: 322 z-score: 449.5 E(): 8.8e-18, 46.1% identity in 115 aa overlap. 46.4% identity to HP0232. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: One probable transmembrace helices identified by TMHMM2.0 within CDS. Some similarity to Helicobacter pylori gene fragment. kept within product function. Functional classification - Surface structures; PMID:8733234; hypothetical protein 340008 904694 Cj0371 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343808.1 339403 D 192222 CDS YP_002343809.1 218562030 904695 340018..341187 1 NC_002163.1 Original (2000) note: Cj0372, unknown, len: 389 aa; similar to hypothetical proteins e.g. YGIC_ECOLI (386 aa),fasta scores; opt: 552 z-score: 508.4 E(): 4.6e-21, 31.3% identity in 383 aa overlap. Also similar to N-terminus of GSP_ECOLI glutathionylspermidine synthase (619 aa), fasta scores; opt: 314 z-score: 248.3 E(): 1.4e-06, 24.4% identity in 381 aa overlap. 60.5% identity to HP0233; Updated (2006) note: Pfam domain PF03738 Glutathionylspermidine synthase identified within CDS. Characterised within Escherichia coli with marginal identity score. Amidase component is most likely not present due to absence at N-terminal end when aligned to Escherichia coli. Product modified to more specific family member based on motif match and characterisation. kept within product function. Functional classification -Misc; PMID:7775463, PMID:9398217; glutathionylspermidine synthase 341187 904695 Cj0372 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glutathionylspermidine synthase YP_002343809.1 340018 D 192222 CDS YP_002343810.1 218562031 904696 341190..342125 1 NC_002163.1 Involved in the metabolism of aromatic amino acids; 2-hydroxyacid dehydrogenase 342125 904696 Cj0373 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 2-hydroxyacid dehydrogenase YP_002343810.1 341190 D 192222 CDS YP_002343811.1 218562032 904697 342115..342606 1 NC_002163.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 342606 904697 Cj0374 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 nucleotide-binding protein YP_002343811.1 342115 D 192222 CDS YP_002343812.1 218562033 904698 342615..343091 1 NC_002163.1 Original (2000) note: Cj0375, probable lipoprotein,len: 158 aa; no Hp match. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification -Membranes, lipoproteins and porins; lipoprotein 343091 904698 Cj0375 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002343812.1 342615 D 192222 CDS YP_002343813.1 218562034 904699 343102..343926 1 NC_002163.1 Original (2000) note: Cj0376, possible periplasmic protein, len: 274 aa; no Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Literature search identified paper linking protein to glycoprotein. Functional classification - Miscellaneous periplasmic proteins; PMID:12186869; periplasmic protein 343926 904699 Cj0376 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343813.1 343102 D 192222 CDS YP_002343814.1 218562035 904700 343926..345638 1 NC_002163.1 Original (2000) note: Cj0377, probable ATPase, len: 570 aa; weak similarity to many members of the AAA family e.g. TR:O28182 (EMBL:O28182) cell division control protein 48 (Archaeoglobus fulgidus AF2098) (811 aa), fasta scores; opt: 341 z-score: 312.6 E(): 3.7e-10, 26.4% identity in 435 aa overlap. No Hp match. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA), score 106.20, E-value 6.3e-28; Updated (2006) note: Probable changed to . No specific characterisation with acceptable identity scores carried out yet. Functional classification - Misc; AAA family ATPase 345638 904700 Cj0377 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 AAA family ATPase YP_002343814.1 343926 D 192222 CDS YP_002343815.1 218562036 904701 complement(345635..346174) 1 NC_002163.1 Original (2000) note: Cj0378c, probable integral membrane protein, len: 179 aa; no Hp match; Updated (2006) note: Pfam domain PF01794 ferric reductase like transmembrane component identified within CDS. This was from a separate Pfam search. Pfam domain PF05252 Uncharacterised protein family (UPF0191) identified within CDS. Six probable transmembrace helices identified by TMHMM2.0 within CDS. Product functionality changed due to motif match. Literature search identified paper giving further support to product function. No specific characterisation has been carried out yet. kept within product function; PMID:15632442; ferric reductase-like transmembrane protein 346174 904701 Cj0378c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ferric reductase-like transmembrane protein YP_002343815.1 345635 R 192222 CDS YP_002343816.1 218562037 904702 complement(346174..347067) 1 NC_002163.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY 347067 904702 Cj0379c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sulfite oxidase subunit YedY YP_002343816.1 346174 R 192222 CDS YP_002343817.1 218562038 904703 complement(347123..347908) 1 NC_002163.1 Original (2000) note: Cj0380c, unknonw, len: 261 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 347908 904703 Cj0380c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343817.1 347123 R 192222 CDS YP_002343818.1 218562039 904704 complement(347905..348744) 1 NC_002163.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 348744 pyrF 904704 pyrF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 orotidine 5'-phosphate decarboxylase YP_002343818.1 347905 R 192222 CDS YP_002343819.1 218562040 904705 complement(348741..349139) 1 NC_002163.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 349139 nusB 904705 nusB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcription antitermination protein NusB YP_002343819.1 348741 R 192222 CDS YP_002343820.1 218562041 904706 complement(349139..349603) 1 NC_002163.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 349603 ribH 904706 ribH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 6,7-dimethyl-8-ribityllumazine synthase YP_002343820.1 349139 R 192222 CDS YP_002343821.1 218562042 904707 complement(349600..350415) 1 NC_002163.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 350415 kdsA 904707 kdsA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 2-dehydro-3-deoxyphosphooctonate aldolase YP_002343821.1 349600 R 192222 CDS YP_002343822.1 218562043 904708 complement(350412..351344) 1 NC_002163.1 Original (2000) note: Cj0385c, probable integral membrane protein, len: 310 aa; similar to many hypothetical integral membrane proteins e.g. TR:O29973 (EMBL:AE001087) Archaeoglobus fulgidus AF0266 (276 aa),fasta scores; opt: 155 z-score: 221.8 E(): 4.5e-05, 26.9% identity in 279 aa overlap. 30.8% identity to HP1234. Contains Pfam match to entry PF00892 DUF6, Integral membrane protein, score 29.90, E-value 5.9e-05; Updated (2006) note: Pfam domain PF00892 Integral membrane protein DUF6 identified within CDS. Ten probable transmembrace helices identified by TMHMM2.0 within CDS. Further support given to product function. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 351344 904708 Cj0385c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343822.1 350412 R 192222 CDS YP_002343823.1 218562044 904709 351446..352828 1 NC_002163.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 352828 engA 904709 engA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GTP-binding protein EngA YP_002343823.1 351446 D 192222 CDS YP_002343824.1 218562045 904710 352815..353312 1 NC_002163.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 353312 aroK 904710 aroK Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 shikimate kinase YP_002343824.1 352815 D 192222 CDS YP_002343825.1 218562046 904711 353309..354268 1 NC_002163.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 354268 trpS 904711 trpS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tryptophanyl-tRNA synthetase YP_002343825.1 353309 D 192222 CDS YP_002343826.1 218562047 904712 354279..355514 1 NC_002163.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 355514 serS 904712 serS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 seryl-tRNA synthetase YP_002343826.1 354279 D 192222 CDS YP_002343827.1 218562048 904713 355524..357986 1 NC_002163.1 Original (2000) note: Cj0390, possible transmembrane protein, len: 820 aa; 28.7% identity in 703 aa overlap to HP1479. Contains possible transmembrane domain around aa 100 and Pfam match to entry PF00515 TPR,TPR Domain, score 26.90, E-value 0.00047; Updated (2006) note: Pfam domains x4 PF07719 Tetratricopeptide repeat were identified within CDS. Functional classification - Membranes, lipoproteins and porins; transmembrane protein 357986 904713 Cj0390 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transmembrane protein YP_002343827.1 355524 D 192222 CDS YP_002343828.1 218562049 904714 complement(358017..358652) 1 NC_002163.1 Original (2000) note: Cj0391c, unknown, len: 211 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Literature search identified paper giving further clues to product function. Functional classification - Unknown; hypothetical protein 358652 904714 Cj0391c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343828.1 358017 R 192222 CDS YP_002343829.1 218562050 904715 complement(358750..360192) 1 NC_002163.1 Original (2000) note: Cj0392c, pyk, probable pyruvate kinase, len: 480 aa; similar to e.g. KPYK_BACSU pyruvate kinase (EC 2.7.1.40) (585 aa), fasta scores; opt: 1111 z-score: 1494.8 E(): 0, 41.8% identity in 476 aa overlap. No Hp match. Contains PS00659 Glycosyl hydrolases family 5 signature and Pfam match to entry PF00224 PK,Pyruvate kinase, score 523.20, E-value 1.8e-153; Updated (2006) note: Pfam domain PF02887 Pyruvate kinase, alpha/beta domain protein was identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with acceptable identity score. not added to product function. Functional classification - Energy metabolism -Glycolysis; PMID:10932722; pyruvate kinase 360192 pyk 904715 pyk Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 pyruvate kinase YP_002343829.1 358750 R 192222 CDS YP_002343830.1 218562051 904716 complement(360241..361587) 1 NC_002163.1 Original (2000) note: Cj0393c, possible oxidoreductase, len: 448 aa; some simlarity to MQO_ECOLI probable malate:quinone oxidoreductase (548 aa), fasta scores; opt: 121 z-score: 223.1 E(): 3.8e-05, 24.6% identity in 455 aa overlap. 49.3% identity to HP0086. Contains PS00110 Pyruvate kinase active site signature; Updated (2006) note: Pfam domain PF06039 Malate:quinone oxidoreductase (Mqo) protein was identified within CDS. Characterised within Helicobacter pylori with acceptable identity score. Product modified to more specific family member due to motif match and characterisation work. kept within product function. Functional classification - Misc; PMID:10809701; malate:quinone oxidoreductase 361587 mqo 904716 mqo Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 malate:quinone oxidoreductase YP_002343830.1 360241 R 192222 CDS YP_002343831.1 218562052 904717 complement(361706..362335) 1 NC_002163.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 362335 904717 Cj0394c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 pantothenate kinase YP_002343831.1 361706 R 192222 CDS YP_002343832.1 218562053 904718 complement(362322..362612) 1 NC_002163.1 Original (2000) note: Cj0395c, unknown, len: 96 aa; no Hp match. Functional classification - Unknown; hypothetical protein 362612 904718 Cj0395c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343832.1 362322 R 192222 CDS YP_002343833.1 218562054 904719 complement(362609..363607) 1 NC_002163.1 Original (2000) note: Cj0396c, probable lipoprotein, len: 332 aa; 28.9% identity to HP0863. Conatins N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification - Membranes, lipoproteins and porins; lipoprotein 363607 904719 Cj0396c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002343833.1 362609 R 192222 CDS YP_002343834.1 218562055 904720 complement(363604..364182) 1 NC_002163.1 Original (2000) note: Cj0397c, unknown, len: 192 aa; almost identical to C. jejuni hypothetical protein fragment TR:Q46096 (EMBL:U27272), 28.5% identity to HP0864; Updated (2006) note: One probable transmembrace helices identified by TMHMM2.0 within CDS. Literature serach identified paper giving further clues about product function. Functional classification - Conserved hypothetical proteins; PMID:10913692; hypothetical protein 364182 904720 Cj0397c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343834.1 363604 R 192222 CDS YP_002343835.1 218562056 904721 364326..364610 1 NC_002163.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 364610 gatC 904721 gatC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aspartyl/glutamyl-tRNA amidotransferase subunit C YP_002343835.1 364326 D 192222 CDS YP_002343836.1 218562057 904722 364678..365241 1 NC_002163.1 Original (2000) note: Cj0399, probable integral membrane protein, len: 187 aa; identical to C. jejuni hypothetical protein fragment TR:O68605 (EMBL:AF052056) (123 aa). 26.9% identity in 171 aa overlap to HP0181 (224 aa); Updated (2006) note: Four probable transmembrace helices identified by TMHMM2.0 within CDS. Pfam domain PF02674 Colicin V production protein identified within CDS. Product modified to more speicific family member based on motif matches. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Misc; colicin V production protein 365241 904722 Cj0399 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 colicin V production protein YP_002343836.1 364678 D 192222 CDS YP_002343837.1 218562058 904724 365243..365716 1 NC_002163.1 Original (2000) note: Cj0400, fur, ferric uptake regulator, len: 157 aa; identical to FUR_CAMJE ferric uptake regulation protein, and highly simliar to many others e.g. FUR_BORPE (139 aa), fasta scores; opt: 354 z-score: 552.9 E(): 1.7e-23 41.6% identity in 137 aa overlap. 40.8% identity to HP1027; Updated (2006) note: Pfam domain PF01475 Ferric uptake regulator family was identified within CDS. Characterised within Campylobacter jejuni. not added to product function. Functional classification -Broad regulatory functions; PMID:8083178, PMID:7590316, PMID:9765558; ferric uptake regulator 365716 fur 904724 fur Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ferric uptake regulator YP_002343837.1 365243 D 192222 CDS YP_002343838.1 218562059 904725 365717..367222 1 NC_002163.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 367222 lysS 904725 lysS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lysyl-tRNA synthetase YP_002343838.1 365717 D 192222 CDS YP_002343839.1 218562060 904726 367219..368463 1 NC_002163.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 368463 glyA 904726 glyA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 serine hydroxymethyltransferase YP_002343839.1 367219 D 192222 CDS YP_002343840.1 218562061 904727 368460..369005 1 NC_002163.1 Original (2000) note: Cj0403, unknown, len: 181 aa; 57.8% identity to HP0184; Updated (2006) note: Literature search identified paper giving further clues to product function. Functional classification - Conserved hypothetical proteins; PMID:12595250; hypothetical protein 369005 904727 Cj0403 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343840.1 368460 D 192222 CDS YP_002343841.1 218562062 904728 369019..369855 1 NC_002163.1 Original (2000) note: Cj0404, probable transmembrane protein, len: 278 aa; no Hp match. Contains probable transmembrane domain around 40 aa; Updated (2006) note: Literature search identified paper giving further clues to product function. Functional classification - Membranes, lipoproteins and porins; PMID:12595250; transmembrane protein 369855 904728 Cj0404 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transmembrane protein YP_002343841.1 369019 D 192222 CDS YP_002343842.1 218562063 904729 369852..370640 1 NC_002163.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 370640 aroE 904729 aroE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 shikimate 5-dehydrogenase YP_002343842.1 369852 D 192222 CDS YP_002343843.1 218562064 904730 complement(370715..371614) 1 NC_002163.1 Original (2000) note: Cj0406c, probable lipoprotein, len: 299 aa; no Hp match. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification - Membranes, lipoproteins and porins; lipoprotein 371614 904730 Cj0406c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002343843.1 370715 R 192222 CDS YP_002343844.1 218562065 904731 371704..372519 1 NC_002163.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 372519 lgt 904731 lgt Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 prolipoprotein diacylglyceryl transferase YP_002343844.1 371704 D 192222 CDS YP_002343845.1 218562066 904732 372589..373371 1 NC_002163.1 part of three member fumarate reductase enzyme complex FrdABC which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdC is the cytochrome b-556 subunit; fumarate reductase cytochrome b-556 subunit 373371 frdC 904732 frdC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 fumarate reductase cytochrome b-556 subunit YP_002343845.1 372589 D 192222 CDS YP_002343846.1 218562067 904733 373355..375346 1 NC_002163.1 part of three member fumarate reductase enzyme complex FrdABC which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdC is the cytochrome b-556 subunit; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 375346 frdA 904733 frdA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 fumarate reductase flavoprotein subunit YP_002343846.1 373355 D 192222 CDS YP_002343847.1 218562068 904734 375339..376064 1 NC_002163.1 part of three member fumarate reductase enzyme complex FrdABC which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdC is the cytochrome b-556 subunit; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 376064 frdB 904734 frdB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 fumarate reductase iron-sulfur subunit YP_002343847.1 375339 D 192222 CDS YP_002343848.1 218562069 904735 376092..378278 1 NC_002163.1 Original (2000) note: Cj0411, probable ATP/GTP binding protein, len: 728 aa; some similarity in C-term to YOR6_CALSR hypothetical protein (402 aa), fasta scores; opt: 220 z-score: 284.9 E(): 1.4e-08, 25.2% identity in 425 aa overlap, and to C-term of YPBR_BACSU hypothetical protein (1193 aa), fasta scores; opt: 173 z-score: 275.1 E(): 5e-08, 20.1% identity in 722 aa overlap. No Hp match. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Pfam domain PF00350 Dynamin family protein was identified within CDS. Dynamin is a member of the G-protein superfamily clan. ATP/GTP binding proteins fall under this particular clan. Further support given to product function. No specific characterisation has been carried out yet. kept within product function. Functional classification - Misc; ATP/GTP binding protein 378278 904735 Cj0411 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP/GTP binding protein YP_002343848.1 376092 D 192222 CDS YP_002343849.1 218562070 904736 378268..380097 1 NC_002163.1 Original (2000) note: Cj0412, probable ATP/GTP binding protein, len: 609 aa; some similarity to YPBR_BACSU hypothetical protein (1193 aa), fasta scores; opt: 172 z-score: 237.5 E(): 6.2e-06, 23.7% identity in 439 aa overlap. No Hp match. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Pfam domain PF00350 Dynamin family protein was identified within CDS. Dynamin is a member of the G-protein superfamily clan. ATP/GTP binding proteins fall under this particular clan. Further support given to product function. Literature search identified paper giving further clues to product function. Functional classification - Misc; ATP/GTP binding protein 380097 904736 Cj0412 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP/GTP binding protein YP_002343849.1 378268 D 192222 CDS YP_002343850.1 218562071 904737 380097..380801 1 NC_002163.1 Original (2000) note: Cj0413, probable periplasmic protein, len: 234 aa; similar to several Hp proteins; HP0160, 30.3% identity; HP0211, 32.6% identity; HP1098 31.1% identity; HP0336 31.3% identity; HP0235 30.9% identity; HP0628 26.5% identity; and HP1117 26.9% identity. This is the only copy in C. jejuni; Updated (2006) note: Pfam domain PF07719 Tetratricopeptide repeat was identified within CDS. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 380801 904737 Cj0413 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343850.1 380097 D 192222 CDS YP_002343851.1 218562072 904738 380937..381665 1 NC_002163.1 Original (2000) note: Cj0414, possible oxidoreductase subunit, len: 242 aa; some similarity to TR:O34213 (EMBL:U97665) Erwinia cypripedii gluconate dehydrogenase subunit III precursor (220 aa), fasta scores; opt: 343 z-score: 502.3 E(): 1.1e-20, 32.6% identity in 193 aa overlap. No Hp match; Updated (2006) note: No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Literature search identified paper giving further clues to product function. Functional classification - Misc; PMID:15231804; oxidoreductase subunit 381665 904738 Cj0414 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 oxidoreductase subunit YP_002343851.1 380937 D 192222 CDS YP_002343852.1 218562073 904739 381667..383388 1 NC_002163.1 Original (2000) note: Cj0415, possible oxidoreductase subunit, len: 573 aa; similar to e.g. TR:O34214 (EMBL:U97665) Erwinia cypripedii gluconate dehydrogenase subunit precursor (615 aa), fasta scores; opt: 1025 z-score: 1674.4 E(): 0, 40.8% identity in 583 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF00732 GMC (glucose-methanol-choline) oxidoreductase was identified within CDS when carrying out own Pfam search. This family is a member of the FAD/NAD(P)-binding Rossmann fold Superfamily clan. These proteins bind FAD as a cofactor. Product modified to more specific family member due to motif match. Literature search identified paper giving further related functional clues. No specific characterisaion with acceptable identity score has been carried out yet, so kept within product function. Literature search identified paper linking protein to glycoprotein (PMID:12186869). Functional classification -Misc; PMID:15231804, PMID:12186869; GMC oxidoreductase subunit 383388 904739 Cj0415 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GMC oxidoreductase subunit YP_002343852.1 381667 D 192222 CDS YP_002343853.1 218562074 904740 383559..383657 1 NC_002163.1 Original (2000) note: Cj0416, unknown, len: 32 aa; no Hp match, highly simlar to N-terminus of Cj0122 (88.2% identity in 34 aa overlap). Functional classification -Unknown; hypothetical protein 383657 904740 Cj0416 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343853.1 383559 D 192222 CDS YP_002343854.1 218562075 904741 383677..383823 1 NC_002163.1 Original (2000) note: Cj0417, unknown, len: 48 aa; no Hp match. Functional classification - Unknown; hypothetical protein 383823 904741 Cj0417 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343854.1 383677 D 192222 CDS YP_002343855.1 218562076 904742 complement(383947..384651) 1 NC_002163.1 Original (2000) note: Cj0418c, unknown, len: 234 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 384651 904742 Cj0418c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343855.1 383947 R 192222 CDS YP_002343856.1 218562077 904743 384759..385121 1 NC_002163.1 Original (2000) note: Cj0419, unknown, len: 120 aa; no Hp match; Updated (2006) note: Pfam domain PF01230 HIT (histidine triad) was identified within CDS by carrying out own Pfam search. Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet. Literature search identified paper giving further information on HIT domains. Functional classification - Misc; PMID:1472710, PMID:9164465; histidine triad (HIT) family protein 385121 904743 Cj0419 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 histidine triad (HIT) family protein YP_002343856.1 384759 D 192222 CDS YP_002343857.1 218562078 904744 385195..385767 1 NC_002163.1 Original (2000) note: Cj0420, probable periplasmic protein, len: 190 aa; similar to hypothetical proteins e.g. YCEI_ECOLI (191 aa), fasta scores; opt: 377 z-score: 504.2 E(): 8.7e-21, 37.4% identity in 195 aa overlap. 37.8% identity to HP1286. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF04264 YceI like family was identified within CDS. Product function was not altered since PF04264 is a base-induced periplasmic protein that has not been characterised. Literature search identified paper linking protein to be a glycoprotein. Functional classification - Miscellaneous periplasmic proteins; PMID:15231804; periplasmic protein 385767 904744 Cj0420 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343857.1 385195 D 192222 CDS YP_002343858.1 218562079 904745 complement(385772..386728) 1 NC_002163.1 Original (2000) note: Cj0421c, probable integral membrane protein, len: 318 aa; no Hp match; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 386728 904745 Cj0421c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343858.1 385772 R 192222 CDS YP_002343859.1 218562080 904746 complement(386790..386999) 1 NC_002163.1 Original (2000) note: Cj0422c, unknown, len: 69 aa; no Hp match. Contains probable helix-turn-helix motif at aa 5-26 (Score 1410, +3.99 SD). Functional classification - Broad regulatory functions; H-T-H containing protein 386999 904746 Cj0422c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 H-T-H containing protein YP_002343859.1 386790 R 192222 CDS YP_002343860.1 218562081 904747 387168..387395 1 NC_002163.1 Original (2000) note: Cj0423, probable integral membrane protein, len: 75 aa; similar to immunity proteins of T4 and T2 phage e.g. IMM_BPT4 immunity protein (83 aa),fasta scores; opt: 174 z-score: 240.8 E(): 4e-06, 40.2% identity in 82 aa overlap. No Hp match; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 387395 904747 Cj0423 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343860.1 387168 D 192222 CDS YP_002343861.1 218562082 904748 387404..388036 1 NC_002163.1 Original (2000) note: Cj0424, probable acidic periplasmic protein, len: 210 aa; no Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF07661 MORN repeat variant was identified within CDS. The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins. The function of this motif is unknown. Literature search identified paper giving functional link to iron stimulation. Functional classification - Miscellaneous periplasmic proteins; PMID:15632442; acidic periplasmic protein 388036 904748 Cj0424 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acidic periplasmic protein YP_002343861.1 387404 D 192222 CDS YP_002343862.1 218562083 904749 388049..388465 1 NC_002163.1 Original (2000) note: Cj0425, probable periplasmic protein, len: 138 aa; no Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Literature search identified paper giving functional link to iron stimulation. Functional classification - Miscellaneous periplasmic proteins; PMID:15632442; periplasmic protein 388465 904749 Cj0425 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343862.1 388049 D 192222 CDS YP_002343863.1 218562084 904750 388595..390172 1 NC_002163.1 Original (2000) note: Cj0426, probable ABC transporter ATP-binding protein, len: 525 aa; simlar to many e.g. YBIT_ECOLI hypothetical ABC transporter ATP-binding protein (530 aa), fasta scores; opt: 1461 z-score: 1750.6 E(): 0, 42.8% identity in 526 aa overlap. 60.5% identity to HP0853. Contains 2x PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry PF00005 ABC_tran, ABC transporters, scores 115.00, E-value 1.4e-30, and 120.70, E-value 2.7e-32; Updated (2006) note: Some characterisation within Escherichia coli with acceptable identity score. added to product function as original designation was only hypothetical. Functional classification -Transport/binding proteins - Other; ABC transporter ATP-binding protein 390172 904750 Cj0426 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter ATP-binding protein YP_002343863.1 388595 D 192222 CDS YP_002343864.1 218562085 904751 390162..390497 1 NC_002163.1 Original (2000) note: Cj0427, unknown, len: 111 aa; no Hp match. Functional classification - Unknown; hypothetical protein 390497 904751 Cj0427 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343864.1 390162 D 192222 CDS YP_002343865.1 218562086 904752 390572..390955 1 NC_002163.1 Original (2000) note: Cj0428, unknown, len: 127 aa; no Hp match; Updated (2006) note: Literature search identified papers linking product function to be involved with motility. Functional classification - Unknown; PMID:15812042, PMID:14985343; hypothetical protein 390955 904752 Cj0428 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343865.1 390572 D 192222 CDS YP_002343866.1 218562087 904753 complement(390999..391583) 1 NC_002163.1 Original (2000) note: Cj0429c, unknown, len: 194 aa; similar to hypothetical proteins e.g. YIGZ_ECOLI (205 aa), fasta scores; opt: 241 z-score: 370.8 E(): 2.3e-13,40.2% identity in 112 aa overlap. 39.1% identity to HP1485 (misannotated as proline dipeptidase); Updated (2006) note: Pfam domain PF01205 Uncharacterized protein family (UPF0029) was identified within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 391583 904753 Cj0429c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343866.1 390999 R 192222 CDS YP_002343867.1 218562088 904754 391711..392937 1 NC_002163.1 Original (2000) note: Cj0430, probable integral membrane protein, len: 408 aa; 33.8% identity to HP1235; Updated (2006) note: Nine probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Literature search identified paper linking product function to stress response. Functional classification - Membranes, lipoproteins and porins; PMID:16045618; integral membrane protein 392937 904754 Cj0430 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343867.1 391711 D 192222 CDS YP_002343868.1 218562089 904723 392930..393544 1 NC_002163.1 Original (2000) note: Cj0431, possible periplasmic ATP/GTP-binding protein, len: 204 aa; no Hp match; contains possible N-terminal signal sequence and PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: One probable transmembrane helices predicted by TMHMM2.0. Functional classification -Miscellaneous periplasmic proteins; periplasmic ATP/GTP-binding protein 393544 904723 Cj0431 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic ATP/GTP-binding protein YP_002343868.1 392930 D 192222 CDS YP_002343869.1 218562090 904757 complement(399936..401144) 1 NC_002163.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 401144 murD 904757 murD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_002343869.1 399936 R 192222 CDS YP_002343870.1 218562091 904758 complement(401144..402205) 1 NC_002163.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 402205 mraY 904758 mraY Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_002343870.1 401144 R 192222 CDS YP_002343871.1 218562092 904759 402285..403763 1 NC_002163.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 403763 pgm 904759 pgm Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoglyceromutase YP_002343871.1 402285 D 192222 CDS YP_002343872.1 218562093 904760 403835..404578 1 NC_002163.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 404578 fabG 904760 fabG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 3-ketoacyl-ACP reductase YP_002343872.1 403835 D 192222 CDS YP_002343873.1 218562094 904761 404585..404995 1 NC_002163.1 Original (2000) note: Cj0436, unknown, len: 136 aa; no Hp match; Updated (2006) note: Pfam domain PF01243 Pyridoxamine 5'-phosphate oxidase was identified within CDS. Product function modified to more specific family member based on motif match. Pyridoxamine 5'-phosphate oxidase (1.4.3.5) is a FMN flavoprotein involved in the de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate. It oxidizes pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P. No specific characterisation with acceptable identity scores has been carried out yet. kept within product function. Functional classification - Biosynthesis of cofactors,prosthetic groups and carriers - Pyridoxine; pyridoxamine 5'-phosphate oxidase 404995 904761 Cj0436 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 pyridoxamine 5'-phosphate oxidase YP_002343873.1 404585 D 192222 CDS YP_002343874.1 218562095 904762 405333..407168 1 NC_002163.1 Original (2000) note: Cj0437, sdhA, probable succinate dehydrogenase flavoprotein subunit, len: 611 aa; similar to many e.g. DHSA_ECOLI succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) (588 aa), fasta scores; opt: 1036 z-score: 1136.5 E(): 0, 37.3% identity in 569 aa overlap and to e.g. FRDA_WOLSU fumarate reductase flavoprotein subunit (656 aa), fasta scores; opt: 862 z-score: 1211.2 E(): 0, 33.3% identity in 595 aa overlap. No Hp ortholog, but 32.3% identity to HP0192 fumarate reductase, flavoprotein subunit (frdA), and 33.8% identity to C. jejuni frdA (Cj0409). Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain, score 386.60,E-value 2.5e-112; Updated (2006) note: Pfam domain PF02910 Fumarate reductase/succinate dehydrogenase identified within CDS. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. Recent EC number update has changed fumarate designation to succinate. not added to product function. Functional classification - Energy metabolism -Tricarboxylic acid cycle; PMID:1556094, PMID:2987185; succinate dehydrogenase flavoprotein subunit 407168 sdhA 904762 sdhA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 succinate dehydrogenase flavoprotein subunit YP_002343874.1 405333 D 192222 CDS YP_002343875.1 218562096 904763 407165..408130 1 NC_002163.1 Original (2000) note: Cj0438, sdhB, possibleble succinate dehydrogenase iron-sulfur protein, len: 321 aa; similar to e.g. DHSB_MYCGR succinate dehydrogenase (ubiquinone) iron-sulfur protein (EC 1.3.5.1) (297 aa),fasta scores; opt: 352 z-score: 442.4 E(): 2.4e-17, 29.3% identity in 215 aa overlap. No Hp ortholog, but 28.1% identical to HP0191 fumarate reductase, iron-sulfur subunit (frdB). Contains PS00197 2Fe-2S ferredoxins,iron-sulfur binding region signature, PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature, and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains., score 13.70,E-value 0.01; Updated (2006) note: Pfam domain PF00111 2Fe-2S iron-sulfur cluster binding domain was identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Energy metabolism -Tricarboxylic acid cycle; succinate dehydrogenase iron-sulfur protein 408130 sdhB 904763 sdhB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 succinate dehydrogenase iron-sulfur protein YP_002343875.1 407165 D 192222 CDS YP_002343876.1 218562097 904764 408134..408991 1 NC_002163.1 Original (2000) note: Cj0439, sdhC, probable succinate dehydrogenase subunit C, len: 285 aa; similar to e.g. TR:P77945 (EMBL:Y09041) Sulfolobus acidocaldarius succinate dehydrogenase subunit C (EC 1.3.99.1) (290 aa),fasta scores; opt: 612 z-score: 739.6 E(): 0, 34.2% identity in 275 aa overlap. No Hp match; Updated (2006) note: Pfam domains x2 PF02754 Cysteine-rich domain was identified within CDS. This domain is usually found in two copies per protein. It contains up to four conserved cysteines. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Energy metabolism -Tricarboxylic acid cycle; succinate dehydrogenase subunit C 408991 sdhC 904764 sdhC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 succinate dehydrogenase subunit C YP_002343876.1 408134 D 192222 CDS YP_002343877.1 218562098 904765 complement(409015..409683) 1 NC_002163.1 Original (2000) note: Cj0440c, probable transcriptional regulator, len: 222 aa; similar to many regulators and to TENA_BACSU transcriptional activator TENA (236 aa), fasta scores; opt: 250 z-score: 275.4 E(): 4.8e-08, 28.8% identity in 215 aa overlap. 30.7% identity to HP1287; Updated (2006) note: Pfam domain PF03070 TENA/THI-4 family was identified within CDS. Further support given to product function. No specific characterisation has been carried out yet. kept within product function. Functional classification - Broad regulatory functions; transcriptional regulator 409683 904765 Cj0440c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcriptional regulator YP_002343877.1 409015 R 192222 CDS YP_002343878.1 218562099 904766 409793..410026 1 NC_002163.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 410026 acpP 904766 acpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acyl carrier protein YP_002343878.1 409793 D 192222 CDS YP_002343879.1 218562100 904767 410053..411267 1 NC_002163.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 411267 fabF 904767 fabF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 3-oxoacyl-ACP synthase YP_002343879.1 410053 D 192222 CDS YP_002343880.1 218562101 904768 411269..412207 1 NC_002163.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 412207 accA 904768 accA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_002343880.1 411269 D 192222 CDS YP_002343881.1 218562102 904770 414516..415112 1 NC_002163.1 Original (2000) note: Cj0447, unknown, len: 198 aa; similar to a hypothetical protein from E. coli; YFFH_ECOLI (191 aa), fasta scores; opt: 168 z-score: 344.6 E(): 6.7e-12, 31.1% identity in 122 aa overlap; and to part of a hypothetical protein from C. elegans TR:Q18745 (EMBL:Z70750) C50F4.11 (1092 aa), fasta scores; opt: 133 z-score: 491.0 E(): 4.7e-20, 35.3% identity in 215 aa overlap. 45.7% identity to HP0507; Updated (2006) note: Pfam domain PF00293 NUDIX was identified within CDS. The generic name 'NUDIX hydrolases' (NUcleoside DIphosphate linked to some other moiety X) has been coined for this domain family . The family can be divided into a number of subgroups, of which MutT anti-mutagenic activity represents only one type; most of the rest hydrolyse diverse nucleoside diphosphate derivatives (including ADP-ribose, GDP- mannose, TDP-glucose, NADH,UDP-sugars, dNTP and NTP). Product modified to more specific family member due to motif match. Functional classification - Misc; NUDIX hydrolase family protein 415112 904770 Cj0447 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NUDIX hydrolase family protein YP_002343881.1 414516 D 192222 CDS YP_002343882.1 218562103 904771 complement(415144..416241) 1 NC_002163.1 Original (2000) note: Cj0448c, probable MCP-type signal transduction protein, len: 365 aa; similar to many proteins with MCP domains e.g. TR:Q56633 (EMBL:L25660) Vibrio cholerae acfB accessory colonization factor (626 aa), fasta scores; opt: 364 z-score: 455.7 E(): 4.4e-18,29.9% identity in 278 aa overlap, and PILJ_PSEAE PILJ protein (682 aa), fasta scores; opt: 314 z-score: 451.9 E(): 7.1e-18, 30.7% identity in 189 aa overlap. 31.9% identity to HP0599 (called hemolysin secretion protein precursor (hylB), but previously sequenced as TR:P94847 H.pylori 48 kDa antigen (433 aa), fasta scores; opt: 580 z-score: 833.7 E(): 0, 32.4% identity in 370 aa overlap). Contains Pfam match to entry PF00015 MCPsignal,Methyl-accepting chemotaxis protein (MCP) signaling domain, score 122.40, E-value 1.7e-33; Updated (2006) note: Prosite domain PS50111 CHEMOTAXIS_TRANSDUC_2, Bacterial chemotaxis sensory transducers domain profile identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Signal transduction; MCP-type signal transduction protein 416241 904771 Cj0448c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MCP-type signal transduction protein YP_002343882.1 415144 R 192222 CDS YP_002343883.1 218562104 904772 complement(416251..416466) 1 NC_002163.1 Original (2000) note: Cj0449c, unknown, len: 71 aa; similar to E. coli hypothetical protein YDCH_ECOLI (55 aa), fasta scores; opt: 112 z-score: 209.2 E(): 0.00023,42.6% identity in 47 aa overlap. 45.1% identity to HP1242; Updated (2006) note: Pfam domain PF04325 Protein of unknown function (DUF465) was identified within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 416466 904772 Cj0449c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343883.1 416251 R 192222 CDS YP_002343884.1 218562105 904773 complement(416651..416845) 1 NC_002163.1 required for 70S ribosome assembly; 50S ribosomal protein L28 416845 rpmB 904773 rpmB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L28 YP_002343884.1 416651 R 192222 CDS YP_002343885.1 218562106 904774 416985..417632 1 NC_002163.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 417632 rep 904774 rep Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribulose-phosphate 3-epimerase YP_002343885.1 416985 D 192222 CDS YP_002343886.1 218562107 904775 417629..418390 1 NC_002163.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 418390 dnaQ 904775 dnaQ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA polymerase III subunit epsilon YP_002343886.1 417629 D 192222 CDS YP_002343887.1 218562108 904776 418573..419865 1 NC_002163.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 419865 thiC 904776 thiC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 thiamine biosynthesis protein ThiC YP_002343887.1 418573 D 192222 CDS YP_002343888.1 218562109 904777 complement(419857..420426) 1 NC_002163.1 Original (2000) note: Cj0454c, possible membrane protein, len: 189 aa; no Hp match; Updated (2006) note: One probable transmembrane helices predicted by TMHMM2.0 within CDS. Literature search identified paper linking product function to motility. Functional classification - Membranes,lipoproteins and porins; PMID:15066034; hypothetical protein 420426 904777 Cj0454c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343888.1 419857 R 192222 CDS YP_002343889.1 218562110 904778 complement(420548..420892) 1 NC_002163.1 Original (2000) note: Cj0455c, possible membrane protein, len: 114 aa; no Hp match; Updated (2006) note: One probable transmembrane helices predicted by TMHMM2.0 within CDS. Functional classification - Membranes, lipoproteins and porins; hypothetical protein 420892 904778 Cj0455c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343889.1 420548 R 192222 CDS YP_002343890.1 218562111 904779 complement(420889..421848) 1 NC_002163.1 Original (2000) note: Cj0456c, unknown, len: 319 aa; no Hp match. Functional classification - Unknown; hypothetical protein 421848 904779 Cj0456c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343890.1 420889 R 192222 CDS YP_002343891.1 218562112 904780 complement(421850..422479) 1 NC_002163.1 Original (2000) note: Cj0457c, probable lipoprotein, len: 209 aa; similar to hypothetical protein fromRICKETTSIA PROWAZEKII TR:E1342403 (EMBL:AJ235270) RP090 (218 aa), fasta scores; opt: 372 z-score: 531.3 E(): 2.7e-22, 33.0% identity in 212 aa overlap. 35.9% identity in 153 aa overlap to HP0270. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Pfam domain PF04028 Domain of unknown function (DUF374) identified within CDS. One probable transmembrane helices predicted by TMHMM2.0 within CDS. Further support given to product function. Functional classification - Membranes, lipoproteins and porins; lipoprotein 422479 904780 Cj0457c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002343891.1 421850 R 192222 CDS YP_002343892.1 218562113 904781 complement(422463..423764) 1 NC_002163.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 423764 miaB 904781 miaB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 (dimethylallyl)adenosine tRNA methylthiotransferase YP_002343892.1 422463 R 192222 CDS YP_002343893.1 218562114 904782 complement(423761..424027) 1 NC_002163.1 Original (2000) note: Cj0459c, unknown, len: 88 aa; 32.5% identical to HP0268. Functional classification -Conserved hypothetical proteins; hypothetical protein 424027 904782 Cj0459c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343893.1 423761 R 192222 CDS YP_002343894.1 218562115 904783 424131..425219 1 NC_002163.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 425219 nusA 904783 nusA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcription elongation factor NusA YP_002343894.1 424131 D 192222 CDS YP_002343895.1 218562116 904784 complement(425235..426422) 1 NC_002163.1 Original (2000) note: Cj0461c, probable integral membrane protein, len: 395 aa; some similarity to a hypothetical protein from B. subtilis TR:O31400 (EMBL:AJ222587) YKUC (430 aa), fasta scores; opt: 172 z-score: 369.7 E(): 2.7e-13, 23.8% identity in 407 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF07690 Major Facilitator Superfamily (MFS) and PF04332 Protein of unknown function (DUF475) were identified within CDS. Twelve probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet. kept within product function. Functional classification - Membranes, lipoproteins and porins; MFS transport protein 426422 904784 Cj0461c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MFS transport protein YP_002343895.1 425235 R 192222 CDS YP_002343896.1 218562117 904785 426496..427542 1 NC_002163.1 Original (2000) note: Cj0462, unknown, len: 348 aa; similar to many hypothetical proteins e.g. TR:O66979 (EMBL:AE000707) Aquifex aeolicus AQ_789 (361 aa), fasta scores; opt: 1202 z-score: 1804.1 E(): 0, 51.4% identity in 348 aa overlap. 66.2% identity to HP0656. Also similar to Cj1368 (35.5% identity in 349 aa overlap); Updated (2006) note: Pfam domain PF04055 Radical SAM superfamily identified within CDS. Radical SAM proteins catalyze diverse reactions, including unusual methylations, isomerization, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation. Prosite PS50887 GGDEF domain identified within CDS. This domain appears to be ubiquitous in bacteria and is often linked to a regulatory domain, such as a phosphorylation receiver or oxygen sensing domain. Product modified to more specific family member due to motif match. Functional classification - Misc; hypothetical protein 427542 904785 Cj0462 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343896.1 426496 D 192222 CDS YP_002343897.1 218562118 904786 427542..428762 1 NC_002163.1 Original (2000) note: Cj0463, zinc protease-like protein, len: 406 aa; some similarity to members of the peptidase M16 (insulinase) family e.g. Y4WB_RHISN hypothetical zinc protease-like protein Y4WB (447 aa),fasta scores; opt: 375 z-score: 306.4 E(): 9.1e-10, 22.7% identity in 396 aa overlap. 39.3% identity to HP0657; Updated (2006) note: Pfam domain PF05193 Peptidase M16 inactive domain identified within CDS. No specific characterisation has been carried out yet. Product function left unchanged. Functional classification -Degradation of macromolecules - Proteins, peptides and glycopeptides; zinc protease-like protein 428762 904786 Cj0463 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 zinc protease-like protein YP_002343897.1 427542 D 192222 CDS YP_002343898.1 218562119 904787 428752..430575 1 NC_002163.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 430575 recG 904787 recG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP-dependent DNA helicase RecG YP_002343898.1 428752 D 192222 CDS YP_002343899.1 218562120 904788 complement(430572..430955) 1 NC_002163.1 Original (2000) note: Cj0465c, unknown, len: 127 aa; identical to C. jejuni hypothetical protein TR:O52917 (EMBL:CJAJ2417) clone 1g9 ORF1 (fragment) (74 aa). No Hp match; Updated (2006) note: Pfam domain PF01152 Bacterial-like globin identified within CDS. This family of heme binding proteins are found mainly in bacteria. Characterised within Campylobacter jejuni. Ctb protein is shown to be involved in moderating oxygen flux within Campylobacter jejuni. NssR (Nitrosative stress sensing Regulator - Cj0466) controls the expression of a nitrosative stress-responsive regulon in Campylobacter jejuni which includes ctb (Cj0465c) and cgb (Cj1586). not added to product function. Functional classification - Energy metabolism - Electron transport; PMID:16681372, PMID:16339953, PMID:16045618,PMID:15292134; group III truncated haemoglobin 430955 ctb 904788 ctb Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 group III truncated haemoglobin YP_002343899.1 430572 R 192222 CDS YP_002343900.1 218562121 904789 431050..431646 1 NC_002163.1 Original (2000) note: Cj0466, probable transcriptional regulator, len: 198 aa; similar to members of the crp/fnr family e.g. CRP_SALTY catabolite gene activator (210 aa), fasta scores; opt: 191 z-score: 236.7 E(): 6.9e-06, 24.1% identity in 195 aa overlap, and FNR_BACSU anaerobic regulatory protein (238 aa), fasta scores; opt: 182 z-score: 215.5 E(): 0.0001, 23.0% identity in 209 aa overlap. No Hp match. Contains helix-turn-helix motif at aa 150-171 (Score 1452, +4.13 SD); Updated (2006) note: Pfam domain PF00027 Cyclic nucleotide-binding domain identified within CDS. Prosite PS50042 CNMP_BINDING_3, Cyclic nucleotide-binding identified within CDS. Characterised within Campylobacter jejuni. NssR (Nitrosative stress sensing Regulator) controls the expression of a nitrosative stress-responsive regulon in Campylobacter jejuni which includes ctb (Cj0465c) and cgb (Cj1586). not added to product function. Functional classification - Broad regulatory functions; PMID:16045618, PMID:15292134, PMID:16339953,PMID:16681372; transcriptional regulator 431646 nssR 904789 nssR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcriptional regulator YP_002343900.1 431050 D 192222 CDS YP_002343901.1 218562122 904790 431662..432363 1 NC_002163.1 Original (2000) note: Cj0467, probable amino-acid ABC transporter integral membrane protein, len: 233 aa; similar to many e.g. GLNP_ECOLI glutamine transport system permease (219 aa), fasta scores; opt: 237 z-score: 468.8 E(): 8.1e-19, 32.6% identity in 233 aa overlap. 45.3% identity to HP1169. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component, score 50.10, E-value 4.9e-11; Updated (2006) note: Literature search identified paper within Campylobacter jejuni linking Cj0467, Cj0468 and Cj0469 as cysteine transporters. Three probable transmembrane helices predicted by TMHMM2.0. not added to product function. Functional classification - Transport/binding proteins - Amino acids and amines; PMID:15948956; amino-acid ABC transporter integral membrane protein 432363 904790 Cj0467 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amino-acid ABC transporter integral membrane protein YP_002343901.1 431662 D 192222 CDS YP_002343902.1 218562123 904791 432356..433012 1 NC_002163.1 Original (2000) note: Cj0468, probable amino-acid ABC transporter integral membrane protein, len: 218 aa; similar to many e.g. GLTJ_ECOLI glutamate/aspartate transport system permease (246 aa), fasta scores; opt: 194 z-score: 425.1 E(): 2.2e-16, 25.7% identity in 222 aa overlap. 49.3% identity to HP1170. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign. and Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component, score 52.80, E-value 7.6e-12; Updated (2006) note: Literature search identified paper within Campylobacter jejuni linking Cj0467, Cj0468 and Cj0469 as cysteine transporters. Five probable transmembrane helices predicted by TMHMM2.0. not added to product function. Functional classification - Transport/binding proteins - Amino acids and amines; PMID:15948956; amino-acid ABC transporter integral membrane protein 433012 904791 Cj0468 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amino-acid ABC transporter integral membrane protein YP_002343902.1 432356 D 192222 CDS YP_002343903.1 218562124 904792 433014..433775 1 NC_002163.1 Original (2000) note: Cj0469, probable amino-acid ABC transporter ATP-binding protein, len: 2t53 aa; highly similar to many e.g. GLNQ_BACST glutamine transport ATP-binding protein (242 aa), fasta scores; opt: 902 z-score: 1279.6 E(): 0, 55.4% identity in 242 aa overlap. 61.4% identity to HP1171. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran, ABC transporters, score 227.80, E-value 1.6e-64; Updated (2006) note: Literature search identified paper within Campylobacter jejuni linking Cj0467, Cj0468 and Cj0469 as cysteine transporters. not added to product function. Functional classification -Transport/binding proteins - Amino acids and amines; PMID:15948956; amino-acid ABC transporter ATP-binding protein 433775 904792 Cj0469 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amino-acid ABC transporter ATP-binding protein YP_002343903.1 433014 D 192222 CDS YP_002343904.1 218562125 904796 434408..435607 1 NC_002163.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 435607 tuf 904796 tuf Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 elongation factor Tu YP_002343904.1 434408 D 192222 CDS YP_002343905.1 218562126 904797 435660..435818 1 NC_002163.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 435818 rpmG 904797 rpmG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L33 YP_002343905.1 435660 D 192222 CDS YP_002343906.1 218562127 904799 435925..436104 1 NC_002163.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 436104 secE 904799 secE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 preprotein translocase subunit SecE YP_002343906.1 435925 D 192222 CDS YP_002343907.1 218562128 904801 436114..436647 1 NC_002163.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 436647 nusG 904801 nusG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcription antitermination protein NusG YP_002343907.1 436114 D 192222 CDS YP_002343908.1 218562129 904802 436673..437098 1 NC_002163.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 437098 rplK 904802 rplK Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L11 YP_002343908.1 436673 D 192222 CDS YP_002343909.1 218562130 904803 437153..437854 1 NC_002163.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 437854 rplA 904803 rplA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L1 YP_002343909.1 437153 D 192222 CDS YP_002343910.1 218562131 904804 438006..438485 1 NC_002163.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 438485 rplJ 904804 rplJ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L10 YP_002343910.1 438006 D 192222 CDS YP_002343911.1 218562132 904805 438506..438883 1 NC_002163.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 438883 rplL 904805 rplL Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L7/L12 YP_002343911.1 438506 D 192222 CDS YP_002343912.1 218562133 904806 438992..443128 1 NC_002163.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 443128 rpoB 904806 rpoB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA-directed RNA polymerase subunit beta YP_002343912.1 438992 D 192222 CDS YP_002343913.1 218562134 904807 443121..447674 1 NC_002163.1 Original (2000) note: Cj0479, rpoC, DNA-directed RNA polymerase beta' chain, len: 1517 aa; highly similar to many e.g. RPOC_ECOLI DNA-directed RNA polymerase beta' chain (EC 2.7.7.6) (1407 aa), fasta scores; opt: 1505 z-score: 5793.8 E(): 0, 46.1% identity in 1541 aa overlap. 69.7% identity to C-terminus of HP1198. Contains Pfam match to entry PF00623 RNA_pol_A, RNA polymerase alpha subunit, score 779.40, E-value 1.4e-230; Updated (2006) note: A total of five Pfam domains have now been identified all encoding the same motif; RNA polymerase Rpb1 domain. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification - RNA synthesis, RNA modification and DNA transcription; PMID:6287430, PMID:6278450; DNA-directed RNA polymerase subunit beta' 447674 rpoC 904807 rpoC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA-directed RNA polymerase subunit beta' YP_002343913.1 443121 D 192222 CDS YP_002343914.1 218562135 904808 complement(447705..448466) 1 NC_002163.1 Original (2000) note: Cj0480c, probable transcriptional regulator, len: 253 aa; similar to many e.g. KDGR_ECOLI transcriptional regulator KDGR (263 aa),fasta scores; opt: 305 z-score: 319.1 E(): 1.8e-10, 24.1% identity in 212 aa overlap. No Hp match. Contains helix-turn-helix motif at aa 21-42 (Score 1424, +4.04 SD); Updated (2006) note: Pfam domain PF01614 Bacterial transcriptional regulator identified within CDS. This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. These proteins have a Helix-Turn-Helix motif at the N-terminus. Further support given to product function. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Broad regulatory functions; transcriptional regulator 448466 904808 Cj0480c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcriptional regulator YP_002343914.1 447705 R 192222 CDS YP_002343915.1 218562136 904809 448697..449605 1 NC_002163.1 Original (2000) note: Cj0481, probable lyase, len: 302 aa; similar to members of the DHDPS family; e.g. DAPA_BACSU dihydrodipicolinate synthase (290 aa), fasta scores; opt: 444 z-score: 557.2 E(): 9.6e-24, 27.6% identity in 275 aa overlap, and NPL_HAEIN probable N-acetylneuraminate lyase subunit (293 aa), fasta scores; opt: 358 z-score: 428.6 E(): 1.4e-16, 28.5% identity in 291 aa overlap. No Hp match. Also similar to C. jejuni dapA, Cj0806; 26.1% identity in 295 aa overlap. ContainsPfam match to entry PF00701 DHDPS,Dihydrodipicolinate synthetase, score 70.30, E-value 4e-17; Updated (2006) note: Based on similarity search results, product modified to more specific family member. Characterised within Bacillus subtilis and Eschereichia coli, however identity scores were marginal. kept within product function. Functional classification - Misc; PMID:8098035, PMID:P9047371; dihydrodipicolinate synthase 449605 dapA 904809 dapA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dihydrodipicolinate synthase YP_002343915.1 448697 D 192222 CDS YP_002343916.1 218562137 5066041 449602..449865 1 NC_002163.1 Original (2000) note: Cj0482, uxaA' possible altronate hydrolase N-terminus, len: 87 aa; similar to N-terminus of e.g. UXAA_ECOLI altronate hydrolase (495 aa), fasta scores; opt: 199 z-score: 322.2 E(): 1.2e-10. 46.2% identity in 78 aa overlap. Simlarity continues in downstream ORF Cj0485. No Hp match. Note that B. subtilis paralog of uxaA, YCBI_BACSU, also has a separate N-terminus (YCBH_BACSU); Updated (2006) note: Pfam domain PF04292 D-galactarate dehydratase / Altronate hydrolase identified within CDS. Further support given to product function. Characterisation work carried out within Escherichia coli with acceptable identity score. C-terminus seems to be downstream Cj0483. Gene names for Cj0482 and Cj0483 are identical with a ' denoting two separate terminals for the same CDS. May well be a pseudogene. kept within product function. Functional classification - Central intermediary metabolism - General; PMID:3038546, PMID:10762278; altronate hydrolase N-terminus 449865 uxaA' 5066041 uxaA' Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 altronate hydrolase N-terminus YP_002343916.1 449602 D 192222 CDS YP_002343917.1 218562138 904810 449862..451034 1 NC_002163.1 Original (2000) note: Cj0483, uxaA' possible altronate hydrolase C-terminus, len: 390 aa; similar to C-terminus of e.g. UXAA_ECOLI altronate hydrolase (495 aa), fasta scores; opt: 832 z-score: 1121.7 E(): 0, 36.1% identity in 391 aa overlap. Simlarity continues from upstream ORF Cj0482. No Hp match. Note that B. subtilis paralog of uxaA, YCBI_BACSU, also has a separate N-terminus (YCBH_BACSU); Updated (2006) note: Pfam domain PF04295 D-galactarate dehydratase / Altronate hydrolase identified within CDS. Further support given to product function. Characterisation work carried out within Escherichia coli with acceptable identity score. N-terminus seems to be downstream Cj0483. Gene names for Cj0482 and Cj0483 are identical with a ' denoting two separate terminals for the same CDS. May well be a pseudogene. kept within product function. Functional classification - Central intermediary metabolism - General; PMID:3038546, PMID:10762278; altronate hydrolase C-terminus 451034 uxaA' 904810 uxaA' Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 altronate hydrolase C-terminus YP_002343917.1 449862 D 192222 CDS YP_002343918.1 218562139 904811 451046..452278 1 NC_002163.1 Original (2000) note: Cj0484, probable transmembrane transport protein, len: 410 aa; similar to members of the phalate transporter family e.g. TR:Q44470 (EMBL:U25634) Agrobacterium vitis tartrate transporter (433 aa), fasta scores; opt: 1004 z-score: 1322.2 E(): 0, 40.4% identity in 408 aa overlap, and PHT1_PSEPU phthalate transporter (451 aa), fasta scores; opt: 663 z-score: 835.4 E(): 0, 29.8% identity in 413 aa overlap. No Hp ortholog; Updated (2006) note: Pfam domain PF07690 Major Facilitator Superfamily (MFS) identified within CDS. Eleven probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member due to motif match. Functional classification -Transport/binding proteins - Other; MFS transport protein 452278 904811 Cj0484 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MFS transport protein YP_002343918.1 451046 D 192222 CDS YP_002343919.1 218562140 904812 452320..453108 1 NC_002163.1 Original (2000) note: Cj0485, probable oxidoreductase, len: 262 aa; similar to many e.g. FABG_AQUAE 3-oxoacyl-[acyl-carrier protein] reductase (248 aa), fasta scores; opt: 384 z-score: 465.5 E(): 1.2e-18,34.3% identity in 254 aa overlap, and BA71_EUBSP 7-alpha-hydroxysteroid dehydrogenase (249 aa), fasta scores; opt: 349 z-score: 421.2 E(): 3.6e-16, 32.3% identity in 254 aa overlap. No Hp ortholog. Also similar to C. jejuni fabG, Cj0435 (31.7% identity in 252 aa overlap). Contains Pfam matches to entry PF00106 adh_short, Alcohol/other dehydrogenases, short chain type,score 143.40, E-value 4e-39 and to entry PF00678 adh_short_C2, Short chain dehydrogenase /reductase C-terminus, score 31.00, E-value 2.7e-05; Updated (2006) note: Characterisation work in more than one species with marginal identity scores. kept within product function. Functional classification -Misc; short chain dehydrogenase 453108 904812 Cj0485 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 short chain dehydrogenase YP_002343919.1 452320 D 192222 CDS YP_002343920.1 218562141 904814 453119..454375 1 NC_002163.1 Original (2000) note: Cj0486, probable sugar transporter, len: 418 aa; simlar to members of the FHS family e.g. FUCP_ECOLI L-fucose permease (438 aa), fasta scores; opt: 848 z-score: 1022.1 E(): 0, 37.2% identity in 390 aa overlap, and GLUP_BRUAB glucose/galactose transporter (412 aa), fasta scores; opt: 456 z-score: 830.5 E(): 0, 33.4% identity in 410 aa overlap. 32.6% identity to HP1174; Updated (2006) note: Pfam domain PF07690 Major Facilitator Superfamily identified within CDS. Prosite PS50850 MFS, Major facilitator superfamily also identified along with twelve probable transmembrane helices predicted by TMHMM2.0. TIGRFAM motif TIGR00885 L-fucose permease was also identified. Fasta search gave high score to L-fucose-proton symporter (L-fucose permease). This permease mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). It can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Other sugar transporters also identified. Product function kept the same along with . Functional classification - Transport/binding proteins - Carbohydrates, organic acids and alcohols; PMID:15919996, PMID:7783647, PMID:8052131; sugar transporter 454375 904814 Cj0486 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sugar transporter YP_002343920.1 453119 D 192222 CDS YP_002343921.1 218562142 904815 454359..455129 1 NC_002163.1 Original (2000) note: Cj0487, unknown, len: 256 aa; some similarity to Y4MH_RHISN hypothetical protein Y4MH (297 aa), fasta scores; opt: 98 z-score: 200.8 E(): 0.00069, 22.7% identity in 295 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF04909 Amidohydrolase identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet. Thus, kept within product function. Functional classification - Misc; amidohydrolase 455129 904815 Cj0487 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amidohydrolase YP_002343921.1 454359 D 192222 CDS YP_002343922.1 218562143 904816 455130..455447 1 NC_002163.1 Original (2000) note: Cj0488, unknown, len: ; similar to a hypothetical protein from B. subtilis TR:O05263 (EMBL:Z93938) YULD(104 aa), fasta scores; opt: 183 z-score: 266.1 E(): 1.6e-07, 33.6% identity in 107 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF05336 Protein of unknown function (DUF718) identified within CDS. Conserved added to product function. Functional classification -Conserved hypothetical proteins; hypothetical protein 455447 904816 Cj0488 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343922.1 455130 D 192222 CDS YP_002343923.1 218562144 5066042 455461..455682 1 NC_002163.1 Original (2000) note: Cj0489, ald', aldehyde dehydrogenase N-terminus, len: 73 aa; highly similar to ALDA_ECOLI aldehyde dehydrogenase A (EC 1.2.1.22) (478 aa), fasta scores; opt: 229 z-score: 319.3 E(): 1.7e-10,51.5% identity in 68 aa overlap. Similarity continues into downstream ORF Cj0490. No error in the sequence can be found. No Hp match; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Gene names for Cj0489 and Cj0490 are identical with a ' denoting two separate terminals for the same CDS. May well be a pseudogene. kept within product function. Functional classification - Central intermediary metabolism - General; PMID:3308886; aldehyde dehydrogenase N-terminus 455682 ald' 5066042 ald' Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aldehyde dehydrogenase N-terminus YP_002343923.1 455461 D 192222 CDS YP_002343924.1 218562145 904817 455718..456899 1 NC_002163.1 Original (2000) note: Cj0490, ald', aldehyde dehydrogenase C-terminus, len: 393 aa; highly similar to ALDA_ECOLI aldehyde dehydrogenase A (EC 1.2.1.22) (478 aa), fasta scores; opt: 1653 z-score: 2398.4 E(): 0, 63.7% identity in 388 aa overlap. Similarity continues from upstream ORF Cj0489. No error in the sequence can be found. No Hp match. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site and Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase, score 433.60, E-value 1.8e-126; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Gene names for Cj0489 and Cj0490 are identical with a ' denoting two separate terminals for the same CDS. May well be a pseudogene. kept within product function. Functional classification - Central intermediary metabolism - General; PMID:3308886; aldehyde dehydrogenase C-terminus 456899 ald' 904817 ald' Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aldehyde dehydrogenase C-terminus YP_002343924.1 455718 D 192222 CDS YP_002343925.1 218562146 904818 457227..457613 1 NC_002163.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 457613 rpsL 904818 rpsL Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S12 YP_002343925.1 457227 D 192222 CDS YP_002343926.1 218562147 904819 457683..458153 1 NC_002163.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 458153 rpsG 904819 rpsG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S7 YP_002343926.1 457683 D 192222 CDS YP_002343927.1 218562148 904822 458166..460241 1 NC_002163.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 460241 fusA 904822 fusA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 elongation factor G YP_002343927.1 458166 D 192222 CDS YP_002343928.1 218562149 904824 460364..460513 1 NC_002163.1 Original (2000) note: Cj0494, small hydrophobic protein, len: 49 aa; no Hp match; Updated (2006) note: Product function modified to more specific family member based on SignalP 2.0 HMM results. kept within product function. Functional classification - Transport/binding proteins - Other; exporting protein 460513 904824 Cj0494 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 exporting protein YP_002343928.1 460364 D 192222 CDS YP_002343929.1 218562150 904825 460519..461220 1 NC_002163.1 Original (2000) note: Cj0495, unknown, len: 233 aa; some simillarity to hypothetical proteins e.g. YABB_BACSU (247 aa), fasta scores; opt: 295 z-score: 352.0 E(): 2.6e-12, 23.9% identity in 230 aa overlap. 36.9% identity to HP1504. Contains PS00092 N-6 Adenine-specific DNA methylases signature; Updated (2006) note: Pfam domain PF05175 methyltransferase small domain and PF08242 Methyltransferase domain identified within CDS. Members of this family are SAM dependent methyltransferases. Prosite domain PS50193 SAM_BIND, SAM (and some other nucleotide) binding motif also identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Misc; PMID:9873033; methyltransferase domain protein 461220 904825 Cj0495 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methyltransferase domain protein YP_002343929.1 460519 D 192222 CDS YP_002343930.1 218562151 904826 461210..461584 1 NC_002163.1 Original (2000) note: Cj0496, unknown, len: 124 aa; similar to hypothetical proteins e.g. TR:O59308 (EMBL:AB009522) Pyrococcus horikoshii PHAV002 (141 aa),fasta scores; opt: 154 z-score: 270.6 E(): 8.8e-08,30.1% identity in 113 aa overlap. 47.5% identity to HP0274; Updated (2006) note: Pfam domain PF03692 Uncharacterised protein family (UPF0153) identified within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 461584 904826 Cj0496 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343930.1 461210 D 192222 CDS YP_002343931.1 218562152 904827 461557..462834 1 NC_002163.1 Original (2000) note: Cj0497, probable lipoprotein,len: 425 aa; some similarity to hypothetical prteins e.g. TR:O67021 (EMBL:AE000710) Aquifex aeolicus AQ_854 (545 aa), fasta scores; opt: 266 z-score: 326.7 E(): 6.7e-11,29.1% identity in 412 aa overlap. 26.7% identity to HP0275 (misannotated as ATP-dependent nuclease (addB)). Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification - Membranes, lipoproteins and porins; lipoprotein 462834 904827 Cj0497 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002343931.1 461557 D 192222 CDS YP_002343932.1 218562153 904828 462831..463607 1 NC_002163.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 463607 trpC 904828 trpC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 indole-3-glycerol-phosphate synthase YP_002343932.1 462831 D 192222 CDS YP_002343933.1 218562154 904829 463617..464102 1 NC_002163.1 Original (2000) note: Cj0499, unknown, len: 161 aa; similar to many members of the HIT family e.g. HIT_BACSU HIT protein (145 aa), fasta scores; opt: 176 z-score: 274.7 E(): 5.2e-08, 26.1% identity in 111 aa overlap. 42.6% identity to HP0741. Contains Pfam match to entry PF01230 HIT, HIT family, score 19.90, E-value 3.6e-06; Updated (2006) note: Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet. kept within product function. Functional classification - Misc; histidine triad (HIT) family protein 464102 904829 Cj0499 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 histidine triad (HIT) family protein YP_002343933.1 463617 D 192222 CDS YP_002343934.1 218562155 904830 464092..465090 1 NC_002163.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase 465090 904830 Cj0500 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tRNA 2-selenouridine synthase YP_002343934.1 464092 D 192222 CDS YP_002343935.1 218562156 904832 complement(466660..467571) 1 NC_002163.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 467571 hemH 904832 hemH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ferrochelatase YP_002343935.1 466660 R 192222 CDS YP_002343936.1 218562157 904833 complement(467568..468434) 1 NC_002163.1 Original (2000) note: Cj0504c, unknown, len: 288 aa; similar to hypothetical proteins e.g. YISS_BACSU 342 aa), fasta scores; opt: 224 z-score: 359.9 E(): 9.4e-13,28.1% identity in 192 aa overlap. 26.4% identity to HP0679; Updated (2006) note: Pfam domain PF01408 Oxidoreductase family, NAD-binding Rossmann fold identified within CDS. Product function modified due to motif match. No specific characterisation has been carried out yet. kept within product function. Functional classification - Misc; oxidoreductase 468434 904833 Cj0504c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 oxidoreductase YP_002343936.1 467568 R 192222 CDS YP_002343937.1 218562158 904834 complement(468439..469512) 1 NC_002163.1 Updated (2006) note: Some characterisation work carried out within Bacillus stearothermophilus with acceptable identity score. kept within product function; Original (2000) note: Cj0505c, possible aminotransferase, len: 357 aa; similar to members of the degT family e.g. DEGT_BACST (372 aa), fasta scores; opt: 857 z-score: 1253.3 E(): 0, 38.8% identity in 356 aa overlap. No Hp ortholog. Contains Pfam match to entry PF01041 DegT_DnrJ_EryC1, DegT/DnrJ/EryC1/StrS family,score 441.40, E-value 7.9e-129; PMID:2104607; DegT family aminotransferase 469512 904834 Cj0505c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DegT family aminotransferase YP_002343937.1 468439 R 192222 CDS YP_002343938.1 218562159 904835 469627..472155 1 NC_002163.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 472155 alaS 904835 alaS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 alanyl-tRNA synthetase YP_002343938.1 469627 D 192222 CDS YP_002343939.1 218562160 904836 472155..472706 1 NC_002163.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 472706 maf 904836 maf Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Maf-like protein YP_002343939.1 472155 D 192222 CDS YP_002343940.1 218562161 904837 472703..474634 1 NC_002163.1 Original (2000) note: Cj0508, pbpA, probable penicillin-binding protein, len: 643 aa; similar to many e.g. PBPB_ECOLI penicillin-binding protein 1B (PBP-1B) (844 aa), fasta scores; opt: 774 z-score: 915.8 E(): 0,32.5% identity in 616 aa overlap. 48.0% identity to HP0597. Also similar to Cj0525c (22.9% identity in 407 aa overlap). Contains Pfam matches to entry PF00912 Transglycosyl, Transglycosylase, score 299.40, E-value 4.5e-86 and Pfam match to entry PF00905 Transpeptidase,Penicillin binding protein transpeptidase domain, score 103.80, E-value 3.3e-27; Updated (2006) note: Characterised within Escherichia coli with marginal identity score. not added to product function. Functional classification -Murein sacculus and peptidoglycan; PMID:11181392, PMID:9841666, PMID:8335642; penicillin-binding protein 474634 pbpA 904837 pbpA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 penicillin-binding protein YP_002343940.1 472703 D 192222 CDS YP_002343941.1 218562162 904838 complement(474662..477235) 1 NC_002163.1 Original (2000) note: Cj0509c, clpB, ATP-dependent CLP protease ATP-binding subunit, len: 857 aa; 98.9% identical to C. jejuni TR:O69287 (EMBL:Y13333) and similar to many e.g. CLAA_LYCES ATP-dependent CLP protease ATP-binding subunit (926 aa), fasta scores; opt: 1130 z-score: 2439.8 E(): 0, 45.0% identity in 845 aa overlap. 61.2% identity to HP0264. Also simlar to C. jejuni clpA (Cj1108); 36.6% identity in 836 aa overlap. Contains 2x PS00017 ATP/GTP-binding site motif A (P-loop), PS00870 and PS00871 Chaperonins clpA/B signatures 1 and 2, and Pfam match to entry PF00495 clpA_B, Chaperonins clpA/B, score 1257.60, E-value 0; Updated (2006) note: Characterised within Campylobacter jejuni. not added to product function. Functional classification - Chaperones,chaperonins, heat shock; PMID:10196475; ATP-dependent Clp protease ATP-binding subunit 477235 clpB 904838 clpB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP-dependent Clp protease ATP-binding subunit YP_002343941.1 474662 R 192222 CDS YP_002343942.1 218562163 904839 complement(477347..477637) 1 NC_002163.1 Original (2000) note: Cj0510c, unknown, len: 96 aa; similar to hypothetical proteins e.g. TR:O32222 (EMBL:Z99121) B. subtilis YVGZ protein (101 aa), fasta scores; opt: 212 z-score: 338.9 E(): 1.4e-11, 40.0% identity in 95 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02583 Uncharacterised BCR, COG1937 identified within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 477637 904839 Cj0510c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343942.1 477347 R 192222 CDS YP_002343943.1 218562164 904840 477755..479089 1 NC_002163.1 Original (2000) note: Cj0511, probable secreted protease, len: 444 aa; similar to many e.g. PRC_ECOLI tail-specific protease precursor (682 aa), fasta scores; opt: 357 z-score: 500.2 E(): 1.4e-20, 29.9% identity in 388 aa overlap. 54.3% identity to HP1350. Contains possible N-terminal signal sequence and Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF)., score 52.00, E-value 1.3e-11; Updated (2006) note: Pfam domain PF03572 Peptidase family S41 identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score. kept within product function. Paper identified linking protein to glycoprotein (PMID:12186869). Functional classification - Protein translation and modification; PMID:8576225, PMID:12186869; secreted protease 479089 904840 Cj0511 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 secreted protease YP_002343943.1 477755 D 192222 CDS YP_002343944.1 218562165 904841 479091..479801 1 NC_002163.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 479801 purC 904841 purC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_002343944.1 479091 D 192222 CDS YP_002343945.1 218562166 904842 479810..480055 1 NC_002163.1 Original (2000) note: Cj0513, unknown, len: 81 aa; similar to many e.g. YEXA_BACSU hypothetical 9.7 kd protein in PURC-PURL intergenic region (84 aa), fasta scores; opt: 248 z-score: 331.6 E(): 3.6e-11, 48.1% identity in 79 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02700 Phosphoribosylformylglycinamidine (FGAM) synthase identified within CDS. Product function modified to new function based on motif match. Characterisation work carried out within Bacillus subtilis with acceptable identity score. not added to product function. Functional classification - Purine ribonucleotide biosynthesis; PMID:15301532, PMID:10071207; phosphoribosylformylglycinamidine synthase 480055 purS 904842 purS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoribosylformylglycinamidine synthase YP_002343945.1 479810 D 192222 CDS YP_002343946.1 218562167 904843 480057..480728 1 NC_002163.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 480728 purQ 904843 purQ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoribosylformylglycinamidine synthase I YP_002343946.1 480057 D 192222 CDS YP_002343947.1 218562168 904844 480700..481896 1 NC_002163.1 Original (2000) note: Cj0515, possible periplasmic protein, len: 398 aa; 27.2% identity to HP1349; Updated (2006) note: One probable transmembrane helices predicted by TMHMM2.0 within CDS. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 481896 904844 Cj0515 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343947.1 480700 D 192222 CDS YP_002343948.1 218562169 904845 481877..482569 1 NC_002163.1 Original (2000) note: Cj0516, plsC, possible 1-acyl-SN-glycerol-3-phosphate acyltransferase, len: 230 aa; similar to e.g. PLCB_HUMAN 1-acyl-SN-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) (278 aa), fasta scores; opt: 227 z-score: 328.0 E(): 5.7e-11, 25.7% identity in 210 aa overlap. 38.4% identity to HP1348; Updated (2006) note: Pfam domain PF01553 Acyltransferase along with Prosite domains PS50239 GLYCEROL_ACYLTRANS, Phospholipid/glycerol acyltransferase and PS00989 CLAT_ADAPTOR_S, Clathrin adaptor complex,small chain were all identified within CDS. Further support given to product function. No specific characterisation with acceptable identity scores carried out yet. kept within product function. Functional classification - Synthesis and modification of macromolecules - Phospholipids; PMID:1557036; 1-acyl-SN-glycerol-3-phosphate acyltransferase 482569 plsC 904845 plsC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 1-acyl-SN-glycerol-3-phosphate acyltransferase YP_002343948.1 481877 D 192222 CDS YP_002343949.1 218562170 904846 482563..482931 1 NC_002163.1 Original (2000) note: Cj0517, crcB, probable integral membrane protein, len: 122 aa; similar to e.g. CRCB_ECOLI CRCB protein (127 aa), fasta scores; opt: 245 z-score: 278.4 E(): 3.2e-08, 37.9% identity in 124 aa overlap. 33.9% identity to HP1225; Updated (2006) note: Pfam domain PF02537 CrcB-like protein identified within CDS. Four probable transmembrane helices predicted by TMHMM2.0 within CDS. Further support given to product function. Functional classification -Membranes, lipoproteins and porins; PMID:2904550; CrcB protein 482931 crcB 904846 crcB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CrcB protein YP_002343949.1 482563 D 192222 CDS YP_002343950.1 218562171 904847 483003..484829 1 NC_002163.1 molecular chaperone; heat shock protein 90 484829 htpG 904847 htpG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 heat shock protein 90 YP_002343950.1 483003 D 192222 CDS YP_002343951.1 218562172 904848 484826..485143 1 NC_002163.1 Original (2000) note: Cj0519, unknown, len: 105 aa; similar to hypothetical proteins e.g. TR:E1342888 (EMBL:AJ235272) Rickettsia prowazekii RP600 (123 aa),fasta scores; opt: 151 z-score: 214.9 E(): 0.00011, 41.6% identity in 89 aa overlap. 34.3% identity to HP1223; Updated (2006) note: Prosite domain PS50206 RHODANESE_3, Rhodanese domain profile also identified within CDS. Rhodanese, a sulphurtransferase involved in cyanide detoxification shares evolutionary relationship with a large family of proteins. This domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases. Product modified to new function based on motif identification. No specific characterisation has been carried out yet, so kept within product function. Functional classification -Misc; rhodanese-like domain protein 485143 904848 Cj0519 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 rhodanese-like domain protein YP_002343951.1 484826 D 192222 CDS YP_002343952.1 218562173 904849 485143..485577 1 NC_002163.1 Original (2000) note: Cj0520, possible membrane protein, len: 144 aa; no Hp match. Contains one possible transmembrane domain at N-terminus. Functional classification - Membranes, lipoproteins and porins; hypothetical protein 485577 904849 Cj0520 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343952.1 485143 D 192222 CDS YP_002343953.1 218562174 904850 485698..486201 1 NC_002163.1 Original (2000) note: Cj0522, possible membrane protein, len: 167 aa; no Hp match. May be fragment of pseudogene; Updated (2006) note: Pfam domain PF02690 Na+/Pi-cotransporter identified within CDS. Three probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet. kept within product function. Functional classification - Transport/binding proteins - Cations; Na+/Pi cotransporter protein 486201 904850 Cj0522 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Na+/Pi cotransporter protein YP_002343953.1 485698 D 192222 CDS YP_002343954.1 218562175 904851 486213..486488 1 NC_002163.1 Original (2000) note: Cj0523, possible membrane protein, len: 91 aa; no Hp match. May be fragment of pseudogene; Updated (2006) note: Three probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; hypothetical protein 486488 904851 Cj0523 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343954.1 486213 D 192222 CDS YP_002343955.1 218562176 904852 486642..487343 1 NC_002163.1 Original (2000) note: Cj0524, unknown, len: 233 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins and cotransporter family proteins from other bacteria. Functional classification - Unknown; hypothetical protein 487343 904852 Cj0524 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343955.1 486642 D 192222 CDS YP_002343956.1 218562177 904853 complement(487340..489148) 1 NC_002163.1 Original (2000) note: Cj0525c, pbpB, probable penicillin-binding protein, len: 602 aa; similar to many e.g. PBP2_NEIME penicillin-binding protein 2 (581 aa),fasta scores; opt: 184 z-score: 511.3 E(): 3.5e-21. 28.9% identity in 443 aa overlap. 35.8% identity to HP1556 (misannotated as cell division protein (ftsI)). Also similar to Cj0508 (22.6% identity in 407 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop),Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain, score 259.30,E-value 5.2e-74 and N-terminal signal sequence; Updated (2006) note: Pfam domain PF03717 Penicillin-binding Protein dimerisation domain identified within CDS. Further support given to product function. Characterised in Bacillus subtilis with marginal identity score. kept within product function. Functional classification - Murein sacculus and peptidoglycan; PMID:8244929, PMID:8289242; penicillin-binding protein 489148 pbpB 904853 pbpB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 penicillin-binding protein YP_002343956.1 487340 R 192222 CDS YP_002343957.1 218562178 904854 complement(489155..489451) 1 NC_002163.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 489451 fliE 904854 fliE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar hook-basal body protein FliE YP_002343957.1 489155 R 192222 CDS YP_002343958.1 218562179 904855 complement(489458..489952) 1 NC_002163.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 489952 flgC 904855 flgC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar basal body rod protein FlgC YP_002343958.1 489458 R 192222 CDS YP_002343959.1 218562180 904856 complement(489962..490393) 1 NC_002163.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal body rod protein FlgB 490393 flgB 904856 flgB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar basal body rod protein FlgB YP_002343959.1 489962 R 192222 CDS YP_002343960.1 218562181 904857 complement(490474..491475) 1 NC_002163.1 Original (2000) note: Cj0529c, unknown, len: 333 aa; similar to hypothetical proteins e.g.YCEG_ECOLI hypothetical 38.2 kd protein in PABC-HOLB intergenic region (340 aa), fasta scores; opt: 326 z-score: 408.1 E(): 1.9e-15, 31.3% identity in 252 aa overlap. 43.0% identity to HP0587 (misannotated as aminodeoxychorismate lyase (pabC)); Updated (2006) note: Pfam domain PF02618 Aminodeoxychorismate lyase identified within CDS. Two probable transmembrane helices predicted by TMHMM2.0 within CDS. This family contains several aminodeoxychorismate lyases. Aminodeoxychorismate lyase is a pyridoxal 5'-phosphate-dependent enzyme that converts 4-aminodeoxychorismate to pyruvate and p-aminobenzoate, a precursor of folic acid in bacteria (PMID:11011151). Product modified to more specific family member based on motif match. No specific characterisation with acceptable identity scores carried out yet. kept within product function. Functional classification -Misc; PMID:11011151; aminodeoxychorismate lyase family protein 491475 904857 Cj0529c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aminodeoxychorismate lyase family protein YP_002343960.1 490474 R 192222 CDS YP_002343961.1 218562182 904858 491390..493960 1 NC_002163.1 Original (2000) note: Cj0530, probable periplasmic protein, len: 856 aa; 22.7% identity to HP0586. Contains N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 493960 904858 Cj0530 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343961.1 491390 D 192222 CDS YP_002343962.1 218562183 904859 494077..496281 1 NC_002163.1 Original (2000) note: Cj0531, icd, probable isocitrate dehydrogenase, len: 734 aa; highly similar to e.g. IDH2_VIBA1 isocitrate dehydrogenase (NADP) 2 (EC 1.1.1.42) (741 aa), fasta scores; opt: 2534 z-score: 3250.7 E(): 0, 53.3% identity in 733 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03971 Monomeric isocitrate dehydrogenase identified within CDS. Further support given to product function. Characterised within Vibrio sp. strain ABE-1 with acceptable identity score. not added to product function. Functional classification - Energy metabolism - Tricarboxylic acid cycle; PMID:8226630, PMID:14702320; isocitrate dehydrogenase 496281 icd 904859 icd Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 isocitrate dehydrogenase YP_002343962.1 494077 D 192222 CDS YP_002343963.1 218562184 904860 496278..497180 1 NC_002163.1 Original (2000) note: Cj0532, mdh, probable malate dehydrogenase, len: 300 aa; MDH_CHLTE malate dehydrogenase (EC 1.1.1.37) (310 aa), fasta scores; opt: 652 z-score: 1151.6 E(): 0, 35.4% identity in 294 aa overlap. No Hp match. Also similar toCj1167 ldh (25.4% identity in 311 aa overlap). Contains Pfam match to entry PF00056 ldh,L-lactate dehydrogenases, score 153.00, E-value 1e-42; Updated (2006) note: Pfam domain PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain identified within CDS. Further support given to product function. Characterised within Chlorobium tepidum and Bacillus subtilis with acceptable identity scores. not added to product function. Functional classification - Energy metabolism - Tricarboxylic acid cycle; PMID:1735722, PMID:8550482, PMID:14702320; malate dehydrogenase 497180 mdh 904860 mdh Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 malate dehydrogenase YP_002343963.1 496278 D 192222 CDS YP_002343964.1 218562185 904861 497181..498344 1 NC_002163.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 498344 sucC 904861 sucC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 succinyl-CoA synthetase subunit beta YP_002343964.1 497181 D 192222 CDS YP_002343965.1 218562186 904862 498354..499223 1 NC_002163.1 Original (2000) note: Cj0534, sucD, probable succinyl-coA synthetase alpha chain, len: 289 aa; highly similar to many e.g. SUCD_ECOLI succinyl-coA synthetase alpha chain (EC 6.2.1.5) (288 aa), fasta scores; opt: 1101 z-score: 1532.0 E(): 0, 58.5% identity in 287 aa overlap. No Hp match. Contains PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1, PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site, and Pfam match to entry PF00549 ligase-CoA,CoA-ligases, score 142.30, E-value 8.6e-39; Updated (2006) note: Pfam domain PF02629 CoA binding domain domain identified within CDS. Further support given to product function. Characterised within Bacillus subtilis and Escherichia coli with acceptable identity scores. not added to product function. Functional classification - Energy metabolism -Tricarboxylic acid cycle; PMID:3543212, PMID:14702320; succinyl-coA synthetase alpha chain 499223 sucD 904862 sucD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 succinyl-coA synthetase alpha chain YP_002343965.1 498354 D 192222 CDS YP_002343966.1 218562187 904863 499238..499549 1 NC_002163.1 Original (2000) note: Cj0535, oorD, probable OORD subunit of 2-oxoglutarate:acceptor oxidoreductase, len: 103 aa; similar to TR:O68227 (EMBL:AF021094) H. pylori OORD subunit of 2-oxoglutarate:acceptor oxidoreductase (113 aa), fasta scores; opt: 436 z-score: 768.9 E(): 0,59.8% identity in 97 aa overlap. 59.8% identity to HP0588. Contains 2x PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains., score 17.40, E-value 0.00091; Updated (2006) note: Characterised within Helicobacter pylori with acceptable identity score. not added to product function. Functional classification - Energy metabolism - Electron transport; PMID:9495749, PMID:7608066, PMID:14702320; 2-oxoglutarate-acceptor oxidoreductase subunit OorD 499549 oorD 904863 oorD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 2-oxoglutarate-acceptor oxidoreductase subunit OorD YP_002343966.1 499238 D 192222 CDS YP_002343967.1 218562188 904864 499558..500682 1 NC_002163.1 Original (2000) note: Cj0536, oorA, probable OORA subunit of 2-oxoglutarate:acceptor oxidoreductase, len: 374 aa; similar to TR:O68228 (EMBL:AF021094) H. pylori OORA subunit of 2-oxoglutarate:acceptor oxidoreductase (371 aa), fasta scores; opt: 1447 z-score: 2256.7 E(): 0,62.7% identity in 351 aa overlap. 63.2% identity to HP0589; Updated (2006) note: Pfam domain PF01855 Pyruvate flavodoxin/ferredoxin oxidoreductase identified within CDS. Further support given to product function. Characterised within Helicobacter pylori with acceptable identity score. not added to product function. Functional classification - Energy metabolism - Electron transport; PMID:9495749, PMID:7608066, PMID:14702320; 2-oxoglutarate-acceptor oxidoreductase subunit OorA 500682 oorA 904864 oorA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 2-oxoglutarate-acceptor oxidoreductase subunit OorA YP_002343967.1 499558 D 192222 CDS YP_002343968.1 218562189 904963 500683..501528 1 NC_002163.1 Original (2000) note: Cj0537, oorB, probable OORB subunit of 2-oxoglutarate:acceptor oxidoreductase, len: 281 aa; similar to TR:O68229 (EMBL:AF021094) H. pylori OORB subunit of 2-oxoglutarate:acceptor oxidoreductase (274 aa), fasta scores; opt: 1356 z-score: 2118.6 E(): 0,69.7% identity in 274 aa overlap. 72.9% identity to HP0590; Updated (2006) note: Pfam domain PF02775 Thiamine pyrophosphate enzyme, C-terminal identified within CDS. Further support given to product function. Characterised within Helicobacter pylori with acceptable identity score. not added to product function. Functional classification - Energy metabolism - Electron transport; PMID:9495749, PMID:7608066, PMID:14702320; 2-oxoglutarate-acceptor oxidoreductase subunit OorB 501528 oorB 904963 oorB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 2-oxoglutarate-acceptor oxidoreductase subunit OorB YP_002343968.1 500683 D 192222 CDS YP_002343969.1 218562190 905096 501525..502082 1 NC_002163.1 Original (2000) note: Cj0538, oorC, probable OORC subunit of 2-oxoglutarate:acceptor oxidoreductase, len: 185 aa; similar to TR:O68230 (EMBL:AF021094) H. pylori OORC subunit of 2-oxoglutarate:acceptor oxidoreductase (184 aa), fasta scores; opt: 714 z-score: 1191.4 E(): 0,59.7% identity in 181 aa overlap. 60.8% identity to HP0591; Updated (2006) note: Pfam domain PF01558 Pyruvate ferredoxin/flavodoxin oxidoreductase identified within CDS. Further support given to product function. Characterised within Helicobacter pylori with acceptable identity score. not added to product function. Functional classification - Energy metabolism - Electron transport; PMID:9495749, PMID:7608066, PMID:14702320; 2-oxoglutarate-acceptor oxidoreductase subunit OorC 502082 oorC 905096 oorC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 2-oxoglutarate-acceptor oxidoreductase subunit OorC YP_002343969.1 501525 D 192222 CDS YP_002343970.1 218562191 904865 502221..502484 1 NC_002163.1 Original (2000) note: Cj0539, unknown, len: 87 aa; no Hp match. Functional classification - Unknown; hypothetical protein 502484 904865 Cj0539 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343970.1 502221 D 192222 CDS YP_002343971.1 218562192 904866 502487..503023 1 NC_002163.1 Original (2000) note: Cj0540, unknown, len: 178 aa; 30.6% identity in 72 aa overlap (N-terminus) to HP0241; Updated (2006) note: Product function modified to more specific family member based on SignalP 2.0 HMM results. kept within product function. Functional classification - Protein and peptide secretion; exporting protein 503023 904866 Cj0540 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 exporting protein YP_002343971.1 502487 D 192222 CDS YP_002343972.1 218562193 904867 503037..503930 1 NC_002163.1 Original (2000) note: Cj0541, probable polyprenyl synthetase, len: 297 aa; similar to many e.g. ISPB_ECOLI octaprenyl-diphosphate synthase (EC 2.5.1.-) (323 aa),fasta scores; opt: 514 z-score: 753.9 E(): 0, 35.2% identity in 281 aa overlap, IDSA_METTM bifunctional short chain isoprenyl diphosphate synthase (324 aa), fasta scores; opt: 549 z-score: 676.0 E(): 2.3e-30, 36.5% identity in 277 aa overlap, and GGPP_SULAC geranylgeranyl pyrophosphate synthetase (330 aa), fasta scores; opt: 330 z-score: 653.2 E(): 4.4e-29, 32.9% identity in 292 aa overlap. 44.6% identity to HP0240. Also similar to Cj1644 (27.6% identity in 268 aa overlap). Contains PS00723 and PS00444 Polyprenyl synthetases signatures 1 and 2, and Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases, score 153.40, E-value 3.8e-42; Updated (2006) note: Similarity to more than one characterised genus with acceptable identity scores. not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Menaquinone and ubiquinine; PMID:8037730; polyprenyl synthetase 503930 904867 Cj0541 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 polyprenyl synthetase YP_002343972.1 503037 D 192222 CDS YP_002343973.1 218562194 904868 503930..505228 1 NC_002163.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 505228 hemA 904868 hemA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glutamyl-tRNA reductase YP_002343973.1 503930 D 192222 CDS YP_002343974.1 218562195 904869 505212..506921 1 NC_002163.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 506921 proS 904869 proS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 prolyl-tRNA synthetase YP_002343974.1 505212 D 192222 CDS YP_002343975.1 218562196 904870 506918..507307 1 NC_002163.1 Original (2000) note: Cj0544, probable integral membrane protein, len: 129 aa; no Hp match; Updated (2006) note: Three probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral memnbrane protein 507307 904870 Cj0544 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral memnbrane protein YP_002343975.1 506918 D 192222 CDS YP_002343976.1 218562197 904871 507304..508227 1 NC_002163.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 508227 hemC 904871 hemC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 porphobilinogen deaminase YP_002343976.1 507304 D 192222 CDS YP_002343977.1 218562198 904873 508224..510026 1 NC_002163.1 Original (2000) note: Cj0546, unknown, len: 600 aa; similar to many hypothetical proteins e.g. YIGC_ECOLI (497 aa), fasta scores; opt: 837 z-score: 852.4 E(): 0, 32.7% identity in 459 aa overlap. 51.6% identity to HP0396; Updated (2006) note: Pfam domain PF01977 3-octaprenyl-4-hydroxybenzoate carboxy-lyase identified within CDS. Product modified to more specific family member due to motif match. Characterised within Escherichia coli with marginal identity scores. Sequence alignment was partial. kept within product function. Functional classification - Misc; PMID:782527, PMID:11029449; 3-octaprenyl-4-hydroxybenzoate carboxylyase 510026 ubiD 904873 ubiD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 3-octaprenyl-4-hydroxybenzoate carboxylyase YP_002343977.1 508224 D 192222 CDS YP_002343978.1 218562199 904874 510184..510549 1 NC_002163.1 possibly involved in flagella export; flagellar protein FlaG 510549 flaG 904874 flaG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar protein FlaG YP_002343978.1 510184 D 192222 CDS YP_002343979.1 218562200 904875 510552..512480 1 NC_002163.1 Also called hook-associated protein 2; involved in flagellin assembly; flagellar capping protein 512480 fliD 904875 fliD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar capping protein YP_002343979.1 510552 D 192222 CDS YP_002343980.1 218562201 904876 512492..512878 1 NC_002163.1 flagellin specific chaperone; flagellar protein FliS 512878 fliS 904876 fliS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar protein FliS YP_002343980.1 512492 D 192222 CDS YP_002343981.1 218562202 904877 512859..513134 1 NC_002163.1 Original (2000) note: Cj0550, unknown, len: 91 aa; no Hp match. Functional classification - Unknown; hypothetical protein 513134 904877 Cj0550 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343981.1 512859 D 192222 CDS YP_002343982.1 218562203 904879 513566..514135 1 NC_002163.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 514135 efp 904879 efp Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 elongation factor P YP_002343982.1 513566 D 192222 CDS YP_002343983.1 218562204 904880 514295..514987 1 NC_002163.1 Original (2000) note: Cj0552, unknown, len: 230 aa; no Hp match. Hydrophobic; Updated (2006) note: Pfam domain PF06149 Protein of unknown function (DUF969) identified within CDS. This is a family of uncharacterised bacterial membrane proteins. Also identified were four probable transmembrane helices predicted by TMHMM2.0. Product function has been changed due to these results. Functional classification -Membranes, lipoproteins and porins; hypothetical protein 514987 904880 Cj0552 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343983.1 514295 D 192222 CDS YP_002343984.1 218562205 904881 514974..515927 1 NC_002163.1 Original (2000) note: Cj0553, probable integral membrane protein, len: 317 aa; no Hp match; Updated (2006) note: Pfam domain PF06166 Protein of unknown function (DUF979) identified within CDS. This family consists of several bacterial membrane proteins. The function of this family is unclear. Also identified were nine probable transmembrane helices predicted by TMHMM2.0. Further support for product function. Functional classification - Membranes,lipoproteins and porins; integral membrane protein 515927 904881 Cj0553 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343984.1 514974 D 192222 CDS YP_002343985.1 218562206 904341 515937..516941 1 NC_002163.1 Original (2000) note: Cj0554, unknown, len: 334 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 516941 904341 Cj0554 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343985.1 515937 D 192222 CDS YP_002343986.1 218562207 904882 517060..518352 1 NC_002163.1 Original (2000) note: Cj0555, probable integral membrane protein, len: 430 aa; similar in N-terminus to an ORF within the Streptococcus pneumoniae cps3E and rpt pseudogene region TR:P72556 (EMBL:U66846) orf5 (197 aa),fasta scores; opt: 493 z-score: 726.3 E(): 3.7e-33, 47.4% identity in 152 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF07158 Dicarboxylate carrier protein MatC N-terminus identified within CDS. This family represents the N-terminal region of the bacterial dicarboxylate carrier protein MatC. MatC protein is an integral membrane protein that can function as a malonate carrier (PMID:9826185). Also identified were eleven probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member due to motif match. No specific characterisation has been carried out, so kept within product function. Functional classification - Carbohydrates, organic acids and alcohols; PMID:9826185; dicarboxylate carrier protein MatC 518352 904882 Cj0555 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dicarboxylate carrier protein MatC YP_002343986.1 517060 D 192222 CDS YP_002343987.1 218562208 904883 518363..519160 1 NC_002163.1 Original (2000) note: Cj0556, unknown, len: 265 aa; no Hp match; Updated (2006) note: Pfam domain PF04909 Amidohydrolase identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet. kept within product function. Functional classification - Misc; amidohydrolase family protein 519160 904883 Cj0556 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amidohydrolase family protein YP_002343987.1 518363 D 192222 CDS YP_002343988.1 218562209 904884 complement(519157..520242) 1 NC_002163.1 Original (2000) note: Cj0557c, probable integral membrane protein, len: 361 aa; similar in C terminus to hypothetical proteins from B. subtilis and E. coli: TR:O32225 (EMBL:O32225) YVAC (631 aa), fasta scores; opt: 271 z-score: 562.0 E(): 5.2e-24, 29.9% identity in 187 aa overlap, and YHFK_ECOLI (696 aa), fasta scores; opt: 182 z-score: 212.9 E(): 0.00015, 27.8% identity in 133 aa overlap. No Hp match; Updated (2006) note: Nine probable transmembrane helices predicted by TMHMM2.0. Further support added to product function. Functional classification - Membranes,lipoproteins and porins; integral membrane protein 520242 904884 Cj0557c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343988.1 519157 R 192222 CDS YP_002343989.1 218562210 904885 complement(520239..521471) 1 NC_002163.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 521471 proA 904885 proA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 gamma-glutamyl phosphate reductase YP_002343989.1 520239 R 192222 CDS YP_002343990.1 218562211 905160 521542..522477 1 NC_002163.1 Original (2000) note: Cj0559, probable oxidoreductase, len: 311 aa; similar to members of the pyridine nucleotide-disulfide oxidoreductases class-II family e.g. R34K_CLOPA 34.2 KD protein in rubredoxin operon (308 aa), fasta scores; opt: 217 z-score: 335.8 E(): 2.1e-11, 23.2% identity in 314 aa overlap, and TRXB_BACSU thioredoxin reductase (315 aa), fasta scores; opt: 192 z-score: 279.9 E(): 2.7e-08, 25.9% identity in 313 aa overlap. 46.3% identity to HP1164. Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Pfam domain PF00070 Pyridine nucleotide-disulfide oxidoreductase identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Misc; pyridine nucleotide-disulphide oxidoreductase 522477 905160 Cj0559 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 pyridine nucleotide-disulphide oxidoreductase YP_002343990.1 521542 D 192222 CDS YP_002343991.1 218562212 905129 522658..523986 1 NC_002163.1 Original (2000) note: Cj0560, probable integral membrane protein, len: 442 aa; similar to many hypothetical proteins e.g. Y709_METJA MJ0709 (450 aa),fasta scores; opt: 402 z-score: 324.8 E(): 8.5e-11, 21.0% identity in 429 aa overlap. 26.3% identity to HP1184; Updated (2006) note: Pfam domain PF01554 MatE identified within CDS. Prosite domain PS00589 PTS_HPR_SER,Phosphotransferase system, HPr serine phosphorylation site also identified. Twelve probable transmembrane helices predicted by TMHMM2.0. Characterised members of the Multi Antimicrobial Extrusion (MATE) family function as drug/sodium antiporters. These proteins mediate resistance to a wide range of cationic dyes, fluroquinolones,aminoglycosides and other structurally diverse antibodies and drugs. MATE proteins are found in bacteria, archaea and eukaryotes. These proteins are predicted to have 12 alpha-helical transmembrane regions (which this one does). Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity scores has been carried out yet. kept within product function. Literature search identified paper giving further clues to product function. Functional classification - Central intermediary metabolism -General; PMID:16048946; MATE family transport protein 523986 905129 Cj0560 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MATE family transport protein YP_002343991.1 522658 D 192222 CDS YP_002343992.1 218562213 905206 complement(524034..524963) 1 NC_002163.1 Original (2000) note: Cj0561c, possible periplasmic protein, len: 309 aa; no Hp match; Updated (2006) note: possible changed to . Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 524963 905206 Cj0561c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002343992.1 524034 R 192222 CDS YP_002343993.1 218562214 904886 525117..526493 1 NC_002163.1 unwinds double stranded DNA; replicative DNA helicase 526493 dnaB 904886 dnaB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 replicative DNA helicase YP_002343993.1 525117 D 192222 CDS YP_002343994.1 218562215 905136 526556..527158 1 NC_002163.1 Original (2000) note: Cj0563, unknown, len: 200 aa; no Hp match. Functional classification - Unknown; hypothetical protein 527158 905136 Cj0563 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343994.1 526556 D 192222 CDS YP_002343995.1 218562216 904359 527149..527355 1 NC_002163.1 Original (2000) note: Cj0564, probable integral membrane protein, len: 68 aa; no Hp match; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 527355 904359 Cj0564 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002343995.1 527149 D 192222 CDS YP_002343996.1 218562217 904889 528182..529648 1 NC_002163.1 Original (2000) note: Cj0566, unknown, len: 488 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 529648 904889 Cj0566 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343996.1 528182 D 192222 CDS YP_002343997.1 218562218 904890 529659..529772 1 NC_002163.1 Original (2000) note: Cj0567, unknown, len: 37 aa; no Hp match; Updated (2006) note: Paper identified linking product function to iron transport or metabolism. Functional classification - Unknown; PMID:15632442; hypothetical protein 529772 904890 Cj0567 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343997.1 529659 D 192222 CDS YP_002343998.1 218562219 904891 529974..530255 1 NC_002163.1 Original (2000) note: Cj0568, unknown, len: 93 aa; no Hp match; Updated (2006) note: One probable transmembrane helices predicted by TMHMM2.0. Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 530255 904891 Cj0568 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343998.1 529974 D 192222 CDS YP_002343999.1 218562220 904892 530261..531130 1 NC_002163.1 Original (2000) note: Cj0569, unknown, len: 289 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 531130 904892 Cj0569 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002343999.1 530261 D 192222 CDS YP_002344000.1 218562221 904893 531139..532206 1 NC_002163.1 Original (2000) note: Cj0570, probable ATP/GTP binding protein, len: 355 aa; 85.1% identity to HP0729. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Functional classification - Conserved hypothetical proteins; ATP/GTP binding protein 532206 904893 Cj0570 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP/GTP binding protein YP_002344000.1 531139 D 192222 CDS YP_002344001.1 218562222 904894 532203..533075 1 NC_002163.1 Original (2000) note: Cj0571, possible transcriptional regulator; len: 290 aa; similar in C-terminus to two hypothetical deoR family transcriptional regulators from E. coli; YFJR_ECOLI (233 aa), fasta scores; opt: 279 z-score: 374.9 E(): 1.4e-13, 27.7% identity in 202 aa overlap, and YAFY_ECOLI (285 aa), fasta scores; opt: 167 z-score: 203.3 E(): 0.0005, 40.4% identity in 57 aa overlap. No Hp match, Contains probable helix-turn-helix motif at aa 25-46 (Score 1541, +4.44 SD); Updated (2006) note: No specific characterisation with acceptable identity scores carried out yet. kept within product function. Literature search identified paper linking product function to be involved in the stringent and heat shock responses within gut colonization. Functional classification - Broad regulatory functions; PMID:15731081; transcriptional regulator 533075 904894 Cj0571 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcriptional regulator YP_002344001.1 532203 D 192222 CDS YP_002344002.1 218562223 904897 533373..534392 1 NC_002163.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein 534392 ribA 904897 ribA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein YP_002344002.1 533373 D 192222 CDS YP_002344003.1 218562224 904898 534404..534847 1 NC_002163.1 Original (2000) note: Cj0573, unknown, len: 147 aa; similar to several hypothetical proteins e.g.YQEY_BACSU (148 aa), fasta scores; opt: 265 z-score: 348.7 E(): 4e-12, 32.9% identity in 140 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02637 GatB/Yqey identified within CDS. This domain is found in GatB and proteins related to bacterial Yqey. Typically about 140 aa residues long. This domain is found at the C terminus of GatB which transamidates Glu-tRNA to Gln-tRNA. The function of this domain is uncertain. It does however suggest that Yqey and its relatives have a role in tRNA metabolism. Product modified to more specific family member due to motif match. kept within product function. Functional classification - Misc; GatB/Yqey family protein 534847 904898 Cj0573 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GatB/Yqey family protein YP_002344003.1 534404 D 192222 CDS YP_002344004.1 218562225 904899 534865..536565 1 NC_002163.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine resistant; also known as acetolactate synthase 3 large subunit; acetolactate synthase 3 catalytic subunit 536565 ilvI 904899 ilvI Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetolactate synthase 3 catalytic subunit YP_002344004.1 534865 D 192222 CDS YP_002344005.1 218562226 904900 536562..537026 1 NC_002163.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 537026 ilvH 904900 ilvH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetolactate synthase 3 regulatory subunit YP_002344005.1 536562 D 192222 CDS YP_002344006.1 218562227 904901 537023..537988 1 NC_002163.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 537988 lpxD 904901 lpxD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_002344006.1 537023 D 192222 CDS YP_002344007.1 218562228 904902 complement(537977..539005) 1 NC_002163.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 539005 queA 904902 queA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 S-adenosylmethionine:tRNA ribosyltransferase-isomerase YP_002344007.1 537977 R 192222 CDS YP_002344008.1 218562229 904903 complement(538998..539735) 1 NC_002163.1 Original (2000) note: Cj0578c, mttB, probable sec-independant protein translocase, len: 245 aa; similar to e.g. TR:G3193219 (EMBL:AF067848) E. coli MTTB (258 aa),fasta scores; opt: 523 z-score: 804.5 E(): 0,36.2% identity in 246 aa overlap. 49.6% identity to HP1061. Contains Pfam match to entry PF00902 UPF0032, Integral membrane protein of unknown function; Updated (2006) note: Pfam domain PF00902 Sec-independent protein translocase identified within CDS. This motif was previously annotated as UPF0032 with unknown function. This family of proteins are involved in a sec-independent translocation mechanism. They are involved in export of redox proteins with a twin arginine leader motif (S/T-R-R-X-F-L-K). The sec-independent pathway is termed TAT for twin-arginine translocation system. Transport proteins with bound cofactors that require folding prior to export are mainly moved. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. not added to product function. Gene name has also been updated from mttB to tatC. Functional classification - Protein and peptide secretion; PMID:9649434, PMID:10652088, PMID:11781311; sec-independent protein translocase 539735 tatC 904903 tatC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sec-independent protein translocase YP_002344008.1 538998 R 192222 CDS YP_002344009.1 218562230 904904 complement(539728..540144) 1 NC_002163.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 540144 904904 Cj0579c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sec-independent translocase YP_002344009.1 539728 R 192222 CDS YP_002344010.1 218562231 905215 complement(540202..541269) 1 NC_002163.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 541269 905215 Cj0580c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 coproporphyrinogen III oxidase YP_002344010.1 540202 R 192222 CDS YP_002344011.1 218562232 905255 541371..541841 1 NC_002163.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 541841 905255 Cj0581 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dinucleoside polyphosphate hydrolase YP_002344011.1 541371 D 192222 CDS YP_002344012.1 218562233 904905 541843..543045 1 NC_002163.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 543045 lysC 904905 lysC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aspartate kinase YP_002344012.1 541843 D 192222 CDS YP_002344013.1 218562234 904906 543046..543582 1 NC_002163.1 Original (2000) note: Cj0583, unknown, len: 178 aa; 30.8% identity to HP1230. Functional classification -Conserved hypothetical proteins; hypothetical protein 543582 904906 Cj0583 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344013.1 543046 D 192222 CDS YP_002344014.1 218562235 904907 543588..544187 1 NC_002163.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 544187 904907 Cj0584 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA polymerase III subunit delta' YP_002344014.1 543588 D 192222 CDS YP_002344015.1 218562236 904908 544189..545331 1 NC_002163.1 Original (2000) note: Cj0585, folP, probable dihydropteroate synthase, len: 380 aa; simliar in C-terminus to e.g. DHPS_ECOLI dihydropteroate synthase (EC 2.5.1.15) (282 aa), fasta scores; opt: 508 z-score: 504.3 E(): 8.5e-21, 35.8% identity in 274 aa overlap. 41.6% identity to HP1232. Contains Pfam match to entry PF00809 DHPS, Dihydropteroate synthase; Updated (2006) note: Pfam domain PF00809 DHPS,Dihydropteroate synthase has now been changed to Pterin binding enzyme. Characterised within Campylobacter jejuni and Escherichia coli with acceptable identity score. removed from product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Folic acid; PMID:10471557, PMID:8244950; dihydropteroate synthase 545331 folP 904908 folP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dihydropteroate synthase YP_002344015.1 544189 D 192222 CDS YP_002344016.1 218562237 904909 545332..547275 1 NC_002163.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 547275 ligA 904909 ligA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NAD-dependent DNA ligase LigA YP_002344016.1 545332 D 192222 CDS YP_002344017.1 218562238 904911 547256..548260 1 NC_002163.1 Original (2000) note: Cj0587, probable integral membrane protein, len: 334 aa; no Hp match; Updated (2006) note: Eight probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 548260 904911 Cj0587 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344017.1 547256 D 192222 CDS YP_002344018.1 218562239 904912 548257..549018 1 NC_002163.1 Original (2000) note: Cj0588, tlyA, possible haemolysin, len: 253 aa; similar to e.g. HLYA_TREHY hemolysin A from Treponema hyodysenteriae (Serpulina hyodysenteriae) (240 aa), fasta scores; opt: 342 z-score: 596.3 E(): 6.4e-26, 33.7% identity in 261 aa overlap. 40.7% identity to HP1086; Updated (2006) note: Pfam domain PF01479 S4 and PF01728 FtsJ-like methyltransferase domain have been identified within CDS. Further support given to product function. Characterisation work carried out within Treponema hyodysenteriae with marginal identity score. kept within product function. Functional classification - Pathogenicity; PMID:1730486; hemolysin 549018 tlyA 904912 tlyA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hemolysin YP_002344018.1 548257 D 192222 CDS YP_002344019.1 218562240 904913 548984..549838 1 NC_002163.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 549838 ribF 904913 ribF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bifunctional riboflavin kinase/FMN adenylyltransferase YP_002344019.1 548984 D 192222 CDS YP_002344020.1 218562241 904914 549825..550535 1 NC_002163.1 Original (2000) note: Cj0590, unknown, len: 236 aa; similar to hypothetical proteins e.g. YECO_ECOLI (247 aa),fasta scores; opt: 476 z-score: 737.5 E(): 0, 35.6% identity in 239 aa overlap. 45.3% identity to HP0388; Updated (2006) note: Prosite domain PS50193 SAM_BIND, SAM (and some other nucleotide) binding motif identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet. kept within product function. Functional classification -Conserved hypothetical proteins; SAM-dependent methyltransferase 550535 904914 Cj0590 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 SAM-dependent methyltransferase YP_002344020.1 549825 D 192222 CDS YP_002344021.1 218562242 904916 complement(550525..550746) 1 NC_002163.1 Original (2000) note: Cj0591c, probable lipoprotein, len: 73 aa; no Hp match. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Some similarity to upstream gene Cj0592c (39.7% identity in 63 aa overlap). Functional classification - Membranes, lipoproteins and porins; lipoprotein 550746 904916 Cj0591c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002344021.1 550525 R 192222 CDS YP_002344022.1 218562243 904917 complement(550743..551177) 1 NC_002163.1 Original (2000) note: Cj0592c, probable periplasmic protein, len: 144 aa; no Hp match. Contains N-terminal signal sequence. Some similarity to downstream gene Cj0591c (39.7% identity in 63 aa overlap). Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 551177 904917 Cj0592c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344022.1 550743 R 192222 CDS YP_002344023.1 218562244 904918 complement(551235..551867) 1 NC_002163.1 Original (2000) note: Cj0593c, probable integral membrane protein, len: 210 aa; similar to hypothetical proteins e.g. YICG_ECOLI (205 aa), fasta scores; opt: 783 z-score: 1285.7 E(): 0, 57.4% identity in 204 aa overlap. No Hp match; Updated (2006) note: Pfam domains x2 PF03458 UPF0126 domain was identified within CDS. This domain is found duplicated in bacterial membrane proteins of unknown function and contains three transmembrane helices. Also seven probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 551867 904918 Cj0593c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344023.1 551235 R 192222 CDS YP_002344024.1 218562245 904919 complement(551878..552528) 1 NC_002163.1 Original (2000) note: Cj0594c, probable periplasmic protein, len: 216 aa; no Hp match. Contains N-terminal signal sequence; Updated (2006) note: Pfam domain PF01223 DNA/RNA non-specific endonuclease was identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity score has been carried out yet. Thus, kept within product function. Functional classification -DNA replication, restriction/modification, recombination and repair; DNA/RNA non-specific endonuclease 552528 904919 Cj0594c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA/RNA non-specific endonuclease YP_002344024.1 551878 R 192222 CDS YP_002344025.1 218562246 904920 complement(552525..553151) 1 NC_002163.1 Original (2000) note: Cj0595c, nth, probable endonuclease III, len 208 aa; similar to many e.g. END3_ECOLI endonuclease III (EC 4.2.99.18) (211 aa), fasta scores; opt: 488 z-score: 749.2 E(): 0, 39.7% identity in 204 aa overlap. 57.4% identity to HP0585. Contains PS00764 Endonuclease III iron-sulfur binding region signature and Pfam match to entry PF00730 Endonuclease_3, Endonuclease III; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -DNA replication, restriction/modification, recombination and repair; PMID:2669955; endonuclease III 553151 nth 904920 nth Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 endonuclease III YP_002344025.1 552525 R 192222 CDS YP_002344026.1 218562247 904921 553232..554053 1 NC_002163.1 Original (2000) note: Cj0596, peb4-cbf2, major antigenic peptide PEB4-cell binding factor 2, len: 273 aa; identical to CBF2_CAMJE cell binding factor 2 precursor,and TR:G451285 peb4=major antigenic peptide (34 aa). Also similar to memebers of the PPIC-parvulin family of rotamases e.g. PRTM_LACPA protease maturation protein precursor (299 aa), fasta scores; opt: 238 z-score: 303.5 E(): 1.3e-09, 31.3% identity in 240 aa overlap, and CYPD_ECOLI peptidyl-prolyl cis-trans isomerase D (623 aa),fasta scores; opt: 244 z-score: 293.9 E(): 4.5e-09, 27.1% identity in 221 aa overlap. 35.7% identity to HP0175. Contains PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature and Pfam match to entry PF00639 Rotamase, PPIC-type PPIASE domain; Updated (2006) note: Characterised within Campylobacter jejuni. Functional classification -Miscellaneous periplasmic proteins; PMID:8525063; major antigenic peptide PEB-cell binding factor 554053 peb4cbf2 904921 peb4cbf2 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 major antigenic peptide PEB-cell binding factor YP_002344026.1 553232 D 192222 CDS YP_002344027.1 218562248 904922 554053..555117 1 NC_002163.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 555117 fba 904922 fba Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 fructose-bisphosphate aldolase YP_002344027.1 554053 D 192222 CDS YP_002344028.1 218562249 904923 555212..556654 1 NC_002163.1 Original (2000) note: Cj0598, probable membrane protein, len: 480 aa; no Hp match; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; hypothetical protein 556654 904923 Cj0598 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344028.1 555212 D 192222 CDS YP_002344029.1 218562250 904924 556651..557604 1 NC_002163.1 Original (2000) note: Cj0599, probable periplasmic protein, len: 317 aa; no Hp match. Contains N-terminal signal sequence; Updated (2006) note: Pfam domain PF00691 OmpA family protein was identified within CDS. Also, one probable transmembrane helix predicted by TMHMM2.0. Further support given to product function. No specific characterisation with acceptable identity scores has been carried out yet. kept within product function. Functional classification - Miscellaneous periplasmic proteins; OmpA family membrane protein 557604 904924 Cj0599 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 OmpA family membrane protein YP_002344029.1 556651 D 192222 CDS YP_002344030.1 218562251 904925 557591..558466 1 NC_002163.1 Original (2000) note: Cj0600, unknown, len: 291 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 558466 904925 Cj0600 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344030.1 557591 D 192222 CDS YP_002344031.1 218562252 904927 complement(558458..559801) 1 NC_002163.1 Original (2000) note: Cj0601c, probable sodium-dependent transmembrane transport protein, len: 447 aa; similar to members of the sodium:neurotransmitter symporter family e.g. YG90_HAEIN hypothetical sodium-dependent transporter HI1690 (457 aa), fasta scores; opt: 1380 z-score: 2645.2 E(): 0, 61.0% identity in 456 aa overlap, and NTSE_RAT sodium-dependent serotonin transporter (630 aa), fasta scores; opt: 265 z-score: 744.2 E(): 0. 25.8% identity in 488 aa overlap. No Hp ortholog. Also similar to Cj0935c (32.4% identity in 451 aa overlap), and Cj0934c (28.0% identity in 454 aa overlap). Contains PS00610 Sodium:neurotransmitter symporter family signature 1 and Pfam match to entry PF00209 SNF, Sodium:neurotransmitter symporter family; Updated (2006) note: Eleven probable transmembrane helices predicted by TMHMM2.0. No specific characterisation with acceptable identity scores carried out yet. kept within product function. Functional classification - Transport/binding proteins - Other; sodium-dependent transmembrane transport protein 559801 904927 Cj0601c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sodium-dependent transmembrane transport protein YP_002344031.1 558458 R 192222 CDS YP_002344032.1 218562253 904928 complement(559852..560520) 1 NC_002163.1 Original (2000) note: Cj0602c, unknown, len: 222 aa; similar to hypothetical proteins e.g. YIIM_ECOLI (234 aa), fasta scores; opt: 298 z-score: 406.4 E(): 2.4e-15,30.4% identity in 207 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF03475 3-alpha domain and PF03473 MOSC domain were identified within CDS. Product modified to more specific family member due to motif match. Functional classification - Misc; MOSC-domain containing protein 560520 904928 Cj0602c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MOSC-domain containing protein YP_002344032.1 559852 R 192222 CDS YP_002344033.1 218562254 904931 complement(560517..562220) 1 NC_002163.1 Original (2000) note: Cj0603c, dsbD, possible thiol:disulfide interchange protein, len: 567 aa; similar to e.g. DSBD_ECOLI thiol:disulfide interchange protein DSBD (488 aa), fasta scores; opt: 795 z-score: 977.8 E(): 0, 31.5% identity in 496 aa overlap. 27.1% identity to HP0265; Updated (2006) note: Pfam domain PF02683 Cytochrome C biogenesis protein transmembrane was identified within CDS. Also, Prosite domain PS50223 THIOREDOXIN_2,Thioredoxin domain 2 identified along with eight probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. DsbA and DsbC periplasmic proteins are involved in disulphide bond formation. DsbD generates a reducing source in the periplasm, which is required for maintaining proper redox conditions. Characterised within Escherichia coli with marginal identity score. kept within product function. Functional classification - Protein translation and modification; PMID:7628442, PMID:11085993; thiol:disulphide interchange protein 562220 dsbD 904931 dsbD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 thiol:disulphide interchange protein YP_002344033.1 560517 R 192222 CDS YP_002344034.1 218562255 904932 562315..563196 1 NC_002163.1 Original (2000) note: Cj0604, unknown, len: 293 aa; similar to hypothetical proteins e.g. TR:O05877 (EMBL:O05877) Mycobacterium tuberculosis Rv3232c (MTCY20B11.07c) (295 aa), fasta scores; opt: 858 z-score: 1317.7 E(): 0, 52.0% identity in 227 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03976 Domain of unknown function (DUF344) was identified within CDS This Pfam has now been modified to Polyphosphate kinase 2. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Misc; PMID:12486232; polyphosphate kinase 563196 904932 Cj0604 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 polyphosphate kinase YP_002344034.1 562315 D 192222 CDS YP_002344035.1 218562256 904933 563205..564395 1 NC_002163.1 Original (2000) note: Cj0605, probable amidohydrolase, len: 396 aa; similar to members of the AMA/HIPO/HYUC family of hydrolases (peptidase family M40) e.g. AMAA_BACST N-acyl-L-amino acid amidohydrolase (370 aa), fasta scores; opt: 805 z-score: 1165.8 E(): 0, 41.4% identity in 307 aa overlap. Also similar to HIPO_CAMJE hippurate hydrolase (Cj0985c) (383 aa) (39.1% identity in 376 aa overlap). No Hp match. Contains PS00070 Aldehyde dehydrogenases cysteine active site; Updated (2006) note: Pfam domain PF01546 Peptidase family M20/M25/M40 was identified within CDS. Further support given to product function. kept within product function. Functional classification - Misc; amidohydrolase 564395 904933 Cj0605 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amidohydrolase YP_002344035.1 563205 D 192222 CDS YP_002344036.1 218562257 904934 564474..565646 1 NC_002163.1 Original (2000) note: Cj0606, probable periplasmic protein, len: 390 aa; similar to hypothetical proteins e.g. E. coli TR:P75830 (EMBL:AE000189) (380 aa), fasta scores; opt: 522 z-score: 648.1 E(): 8.4e-29, 31.3% identity in 386 aa overlap. No Hp ortholog. Contains probable N-terminal signal sequence and poly-Serine tract from aa 211 to 225; Updated (2006) note: Pfam domain PF00529 HlyD family secretion protein was identified within CDS. Literature search identified paper linking the three-gene operon Cj0606-0608) to a type-one secretion system. Each of the three CDSs show characteristics similar to the alpha-haemolysin secretion system of Escherichia coli (PMID:8137117). Product modified to more specific family member due to motif match. Some characterisation work carried out within Escherichia coli (marginal identity score) and designated as macrolide-specific ABC-type efflux transporter. kept within product function. Functional classification - Protein and peptide secretion; PMID:15554967, PMID:8137117, PMID:11544226; secretion protein HlyD 565646 904934 Cj0606 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 secretion protein HlyD YP_002344036.1 564474 D 192222 CDS YP_002344037.1 218562258 904935 565646..567571 1 NC_002163.1 Original (2000) note: Cj0607, probable ABC-type transmembrane transport protein, len: 641 aa; similar to many predicted ABC transporters e.g. YBJZ_ECOLI (648 aa),fasta scores; opt: 1729 z-score: 1619.1 E(): 0, 44.3% identity in 632 aa overlap. No Hp ortholog. Contains 2x PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, Pfam match to entry PF00005 ABC_tran, ABC transporters, and two possible membrane-spanning regions; Updated (2006) note: Literature search identified paper linking the three-gene operon (Cj0606-0608) to a type-one secretion system. Each of the three CDSs show characteristics similar to the alpha-haemolysin secretion system of E.coli (PMID:8137117). Some characterisation work carried out within Escherichia coli (marginal identity score) and designated as macrolide-specific ABC-type efflux transporter. not added to product function. Functional classification -Transport/binding proteins - Other; PMID:15554967, PMID:8137117, PMID:11544226; ABC transporter transmembrane protein 567571 904935 Cj0607 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter transmembrane protein YP_002344037.1 565646 D 192222 CDS YP_002344038.1 218562259 904936 567573..568943 1 NC_002163.1 Original (2000) note: Cj0608, possible outer membrane protein, len: 456 aa; similar to hypothetical proteins e.g. YE62_HAEIN HI1462 (454 aa), fasta scores; opt: 711 z-score: 933.7 E(): 0, 29.8% identity in 450 aa overlap, and weakly to outer membrene proteins e.g. TR:Q51006 (EMBL:X95635) Neisseria gonorrhoeae MTRE gene (fragment) (467 aa), fasta scores; opt: 289 z-score: 325.5 E(): 8.3e-11, 22.8% identity in 465 aa overlap. No Hp match. Also similar to Cj0365c (28.6% identity in 455 aa overlap). Contains N-terminal signal sequence, PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS00217 Sugar transport proteins signature 2; Updated (2006) note: Pfam domain PF02321 Outer membrane efflux protein was identified within CDS. Product modified to more specific family member due to motif match. Literature search identified paper linking the three-gene operon (Cj0606-0608) to a type-one secretion system. Each of the three CDSs show characteristics similar to the alpha-haemolysin secretion system of E.coli (PMID:8137117). kept within product function. Functional classification -Transport/binding proteins - Other; PMID:15554967, PMID:8137117, PMID:11544226; outer membrane efflux protein 568943 904936 Cj0608 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 outer membrane efflux protein YP_002344038.1 567573 D 192222 CDS YP_002344039.1 218562260 904937 complement(568946..570124) 1 NC_002163.1 Original (2000) note: Cj0609c, possible periplasmic protein, len: 392 aa; no Hp match. Contains possible N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 570124 904937 Cj0609c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344039.1 568946 R 192222 CDS YP_002344040.1 218562261 904522 complement(570111..571121) 1 NC_002163.1 Original (2000) note: Cj0610c, probable periplasmic protein, len: 336 aa; no Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF04311 Protein of unknown function (DUF459) was identified within CDS. Product function kept the same. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 571121 904522 Cj0610c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344040.1 570111 R 192222 CDS YP_002344041.1 218562262 904938 complement(571122..572498) 1 NC_002163.1 Original (2000) note: Cj0611c, probable transmembrane transport protein, len: 458 aa; similar to e.g. TR:Q51392 (EMBL:U50202) Pseudomonas aeruginosa ALGI (520 aa), fasta scores; opt: 729 z-score: 779.3 E(): 0,32.5% identity in 428 aa overlap, and DLTB_BACSU DLTB protein (395 aa), fasta scores; opt: 431 z-score: 482.4 E(): 1.4e-19, 29.6% identity in 361 aa overlap. 32.9% identity to HP0855; Updated (2006) note: Pfam domain PF03062 MBOAT family identified within CDS. Also, 11 probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity scores identified yet. kept within product function. Functional classification - Misc; PMID:8636017, PMID:11208804; acyltransferase family protein 572498 904938 Cj0611c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acyltransferase family protein YP_002344041.1 571122 R 192222 CDS YP_002344042.1 218562263 904939 complement(572541..573044) 1 NC_002163.1 Original (2000) note: Cj0612c, cft, probable ferritin, len: 167 aa; identical to TR:Q46106 (EMBL:D64082), and similar to many e.g. FTN_ECOLI ferritin (165 aa), fasta scores; opt: 535 z-score: 957.6 E(): 0,47.2% identity in 161 aa overlap. 63.9% identity to HP0653. Contains Pfam match to entry PF00210 ferritin; Updated (2006) note: Characterised within Campylobacter jejuni. Functional classification -Transport/binding proteins - Cations; PMID:8809765; ferritin 573044 cft 904939 cft Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ferritin YP_002344042.1 572541 R 192222 CDS YP_002344043.1 218562264 904940 573224..574219 1 NC_002163.1 Original (2000) note: Cj0613, pstS, possible periplasmic phosphate binding protein, len: 167 aa; similar to e.g. SPHX_SYNP7 SPHX protein precursor (337 aa), fasta scores; opt: 346 z-score: 602.6 E(): 2.9e-26,33.2% identity in 301 aa overlap. No Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Characterised within Escherichia coli, however, identity score was unnacceptable. kept within product function. Functional classification - Transport/binding proteins -Anions; PMID:2651888, PMID:7741855; periplasmic phosphate binding protein 574219 pstS 904940 pstS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic phosphate binding protein YP_002344043.1 573224 D 192222 CDS YP_002344044.1 218562265 904941 574229..575143 1 NC_002163.1 Original (2000) note: Cj0614, pstC, probable phosphate transport system permease, len: 304 aa; similar to e.g. PSTC_ECOLI phosphate transport system permease (319 aa), fasta scores; opt: 289 z-score: 590.3 E(): 1.4e-25, 28.9% identity in 305 aa overlap. No Hp ortholog. Also similar to downstream gene Cj0615 (30.7% identity in 254 aa overlap). Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Characterised within Pseudomonas putida and Escherichia coli, however, identity scores were unnacceptable. kept within product function. Functional classification - Transport/binding proteins - Anions; PMID:16232467, PMID:2646285; phosphate transport system permease 575143 pstC 904941 pstC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphate transport system permease YP_002344044.1 574229 D 192222 CDS YP_002344045.1 218562266 904942 575140..576228 1 NC_002163.1 Original (2000) note: Cj0615, pstA, probable phosphate transport system permease, len: 362 aa; similar to e.g. PSTA_ECOLI phosphate transport system permease (296 aa), fasta scores; opt: 346 z-score: 447.5 E(): 1.3e-17, 29.2% identity in 226 aa overlap. No Hp ortholog. Also similar to upstream gene Cj0614 (30.7% identity in 254 aa overlap). Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Characterised within Escherichia coli, however, identity scores were unnacceptable. kept within product function. Functional classification - Transport/binding proteins -Anions; PMID:2993631, PMID:2896188; phosphate transport system permease 576228 pstA 904942 pstA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphate transport system permease YP_002344045.1 575140 D 192222 CDS YP_002344046.1 218562267 904943 576225..576965 1 NC_002163.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate ABC transporter ATP-binding protein 576965 pstB 904943 pstB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphate ABC transporter ATP-binding protein YP_002344046.1 576225 D 192222 CDS YP_002344047.1 218562268 904944 577027..577638 1 NC_002163.1 Original (2000) note: Cj0617, unknown, len: 203 aa; no Hp match. A member of the 617 family of C.j. proteins containing homopolymeric tracts; similar to N-terminus of Cj1305c (38.9% identity in 180 aa overlap), Cj1306c (39.2% identity in 181 aa overlap), Cj1310c (37.4% identity in 182 aa overlap) and Cj1342c (49.7% identity in 191 aa overlap). The similarities continue in the downstream ORF Cj0618, suggesting that these two ORFs may encode a single protein, but are frameshifted w.r.t. each other. There is a poly-G tract at the site of the possible frameshift (577586..577594) and all of the similar genes contain variable poly-G tracts at this position. Functional classification - Unknown; hypothetical protein 577638 904944 Cj0617 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344047.1 577027 D 192222 CDS YP_002344048.1 218562269 904945 577608..578255 1 NC_002163.1 Original (2000) note: Cj0618, unknown, len: 215 aa; no Hp match. A member of the 617 family of C.j. proteins containing homopolymeric tracts; similar to C-terminus of Cj1305c (36.7% identity in 221 aa overlap), Cj1306c (39.1% identity in 220 aa overlap), Cj1310c (33.6% identity in 220 aa overlap) and Cj1342c (43.4% identity in 221 aa overlap). The similarities continue from the upstream ORF Cj0617, suggesting that these two ORFs may encode a single protein, but are frameshifted w.r.t. each other. There is a poly-G tract at thesite of the possible frameshift (577586..577594) and all of the similar genes contain variable poly-G tracts at this position; Updated (2006) note: Literature search identified paper giving functional link to motility. Functional classification - Unknown; PMID:15066034; hypothetical protein 578255 904945 Cj0618 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344048.1 577608 D 192222 CDS YP_002344049.1 218562270 904946 578345..579661 1 NC_002163.1 Original (2000) note: Cj0619, probable integral membrane protein, len: 438 aa; similar to hypothetical proteins e.g. TR:O07940 B. subtilis YISQ (455 aa), fasta scores; opt: 880 z-score: 1364.9 E(): 0, 32.1% identity in 446 aa overlap, and YEEO_ECOLI (547 aa), fasta scores; opt: 164 z-score: 529.6 E(): 3.3e-22, 22.7% identity in 437 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF01554 MatE was identified within CDS. This family of protein function as drug/sodium antiporters. These proteins mediate resistance to a wide range of cationic dyes, fluroquinolones,aminoglycosides and other structurally diverse antibodies and drugs. MatE proteins are found in bacteria, archaea and eukaryotes. These proteins are predicted to have 12 alpha-helical transmembrane regions (which this CDS has). Product modified to more specific family member due to motif match. Literature search identified paper giving further support. Functional classification -Membranes, lipoproteins and porins; PMID:16048946; MATE family transport protein 579661 904946 Cj0619 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MATE family transport protein YP_002344049.1 578345 D 192222 CDS YP_002344050.1 218562271 904947 579637..580284 1 NC_002163.1 Original (2000) note: Cj0620, unknown, len: 215 aa; some simlarity to TR:O58443 (EMBL:AB009490) Pyrococcus horikoshii PHCF016 (230 aa), fasta scores; opt: 229 z-score: 237.3 E(): 6.4e-06, 26.9% identity in 197 aa overlap. 33.7% identity to HP0806, 25.0% identity to HP1401; Updated (2006) note: Pfam domain PF01863 Protein of unknown function DUF45 identified within CDS. This motif has no known function. Members are found in some archaebacteria, as well as Helicobacter pylori (Epsilon Proteobacteria). The proteins are 190-240 amino acids long, with the C terminus being the most conserved region,containing three conserved histidines. This motif is similar to that found in Zinc proteases, suggesting a possible role as a protease. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 580284 904947 Cj0620 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344050.1 579637 D 192222 CDS YP_002344051.1 218562272 904948 580326..581846 1 NC_002163.1 Original (2000) note: Cj0621, unknown, len: 506 aa; similar to TR:E1186594 (EMBL:AJ003049) hypothetical protein HYDE from Wolinella succinogenes (546 aa), fasta scores; opt: 207 z-score: 285.3 E(): 1.3e-08, 25.8% identity in 551 aa overlap. 23.2% identity to HP0635; Updated (2006) note: Literature search identified paper linking product function to hydE-like protein. Functional classification - Conserved hypothetical proteins; PMID:10533287; hypothetical protein 581846 904948 Cj0621 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344051.1 580326 D 192222 CDS YP_002344052.1 218562273 904949 581827..584016 1 NC_002163.1 Original (2000) note: Cj0622, hypF, probable transcriptional regulatory protein, len: 729 aa; similar to many e.g. HYPF_ECOLI transcriptional regulatory protein HYPF (750 aa), fasta scores; opt: 1166 z-score: 1359.5 E(): 0, 34.1% identity in 747 aa overlap. 35.0% identity to HP0048. Contains PS00150 Acylphosphatase signature 1 and Pfam match to entry PF01300 Sua5_yciO_yrdC,SUA5/yciO/yrdC family; Updated (2006) note: Pfam domain PF07503 HypF finger was identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score. Product function updated with new EC number. not added to product function. Functional classification - Energy metabolism -Respiration; PMID:15504408, PMID:1849603; carbamoyltransferase 584016 hypF 904949 hypF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 carbamoyltransferase YP_002344052.1 581827 D 192222 CDS YP_002344053.1 218562274 904950 584094..584837 1 NC_002163.1 Original (2000) note: Cj0623, hypB, probable hydrogenase isoenzymes formation protein, len: 247 aa; similar to many e.g. HYPB_ECOLI hydrogenase isoenzymes formation protein (290 aa), fasta scores; opt: 691 z-score: 1142.3 E(): 0, 46.1% identity in 230 aa overlap. 44.2% identity to HP0900. Contains PS00028 Zinc finger,C2H2 type, domain; Updated (2006) note: Pfam domain PF02492 CobW/HypB/UreG, nucleotide-binding domain was identified within CDS. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification - Energy metabolism -Respiration; PMID:7601092, PMID:1849603; hydrogenase isoenzymes formation protein 584837 hypB 904950 hypB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hydrogenase isoenzymes formation protein YP_002344053.1 584094 D 192222 CDS YP_002344054.1 218562275 904953 584837..585118 1 NC_002163.1 Original (2000) note: Cj0624, hypC, probable hydrogenase isoenzymes formation protein, len: 93 aa; similar to many e.g. HYPC_ECOLI hydrogenase isoenzymes formation protein (90 aa), fasta scores; opt: 145 z-score: 173.2 E(): 0.024, 35.9% identity in 78 aa overlap. 53.3% identity to HP0899; Updated (2006) note: Pfam domain PF01455 HupF/HypC family protein was identified within CDS. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Energy metabolism - Respiration; PMID:8021226, PMID:1849603; hydrogenase isoenzymes formation protein 585118 hypC 904953 hypC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hydrogenase isoenzymes formation protein YP_002344054.1 584837 D 192222 CDS YP_002344055.1 218562276 904954 585102..586193 1 NC_002163.1 Original (2000) note: Cj0625, hypD, probable hydrogenase isoenzymes formation protein, len: 363 aa; similar to many e.g. HYPD_ECOLI hydrogenase isoenzymes formation protein (373 aa), fasta scores; opt: 1097 z-score: 1671.2 E(): 0, 41.3% identity in 368 aa overlap. 58.5% identity to HP0898; Updated (2006) note: Pfam domain PF01924 Hydrogenase formation hypA family protein was identified within CDS. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification - Energy metabolism -Respiration; PMID:1849603; hydrogenase isoenzymes formation protein 586193 hypD 904954 hypD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hydrogenase isoenzymes formation protein YP_002344055.1 585102 D 192222 CDS YP_002344056.1 218562277 904955 586190..587164 1 NC_002163.1 Original (2000) note: Cj0626, hypE, probable hydrogenase isoenzymes formation protein, len: 324 aa; similar to many e.g. HYPE_ECOLI hydrogenase isoenzymes formation protein (322 aa), fasta scores; opt: 705 z-score: 923.2 E(): 0, 40.4% identity in 327 aa overlap. 46.8% identity to HP0047. Contains Pfam match to entry PF00586 AIRS, AIR synthase related proteins; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Energy metabolism - Respiration; PMID:1849603; hydrogenase isoenzymes formation protein 587164 hypE 904955 hypE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hydrogenase isoenzymes formation protein YP_002344056.1 586190 D 192222 CDS YP_002344057.1 218562278 904956 587164..587508 1 NC_002163.1 Original (2000) note: Cj0627, hypA, probable hydrogenase isoenzymes formation protein, len: 114 aa; similar to e.g. HYPA_AZOVI hydrogenase expression/formation protein (113 aa), fasta scores; opt: 228 z-score: 397.9 E(): 7.2e-15, 32.4% identity in 111 aa overlap. 39.7% identity to HP0869. Contains Pfam match to entry PF01155 HypA, Hydrogenase expression/synthesis hypA family; Updated (2006) note: Characterised within Azotobacter vinelandii and Escherichia coli with marginal identity scores. not added to product function. Functional classification - Energy metabolism -Respiration; PMID:1849603, PMID:1610901; hydrogenase expression/formation protein 587508 hypA 904956 hypA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hydrogenase expression/formation protein YP_002344057.1 587164 D 192222 CDS YP_002344058.1 218562279 904958 join(587868..588371,588373..591303) 1 NC_002163.1 Original (2000) note: Cj0628, probable lipoprotein,len: 171 aa; no Hp match. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. There is a variable poly-T tract at the C-terminus T(4-5). T5 causes the ORF to stop here, T4 allows translation into the downstream ORF Cj0629. Similar to Cj1677 (42.4% identity in 172 aa overlap). Cj1677 has a non-variable poly-T tract in an quivalent position, which could allow translation into Cj1678 (highly similar to Cj0629); Original (2000) note: Cj0629, possible lipoprotein,len: 978 aa; no Hp match. Contains a variable poly-T tract at the N-terminus T(4-5). T5 causes the ORF to start here,T4 allows translation from the upstream ORF Cj0628 (which contains a signal sequence and lipid attachment site). Highly similar to Cj1678 (90.7% identity in 901 aa overlap). Cj1678 has a non-variable poly-T tract in an quivalent position, which could allow translation from Cj1677 (similar to Cj0628); Updated (2006) note: Coding sequences have been merged to reflect the complete amino acid sequence for this gene regardless of phase. Previous annotation gave Cj0628 and Cj0629 as seperate CDS. Merging of these CDSs has lead to loss of the downstream CDS. Functional classification - Membranes, lipoproteins and porins; lipoprotein 591303 904958 Cj0628 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002344058.1 587868 D 192222 CDS YP_002344059.1 218562280 904888 complement(591537..592502) 1 NC_002163.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 592502 904888 Cj0630c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA polymerase III subunit delta YP_002344059.1 591537 R 192222 CDS YP_002344060.1 218562281 904960 complement(592495..594429) 1 NC_002163.1 Original (2000) note: Cj0631c, possible ribonuclease, len: 644 aa; similar to members of the ribonuclease II (RNB) family, e.g. VACB_ECOLI VACB protein (813 aa), fasta scores; opt: 503 z-score: 829.1 E(): 0,31.0% identity in 580 aa overlap. 35.1% identity to HP1248. Contains PS01175 Ribonuclease II family signature,and Pfam match to entry PF00773 RNB, RNB-like proteins; Updated (2006) note: Some characterisation within Escherichia coli, however, identity scores were marginal. kept within product function. Functional classification - Degradation of macromolecules; PMID:9603904; ribonuclease 594429 904960 Cj0631c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribonuclease YP_002344060.1 592495 R 192222 CDS YP_002344061.1 218562282 904961 594548..595570 1 NC_002163.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 595570 ilvC 904961 ilvC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ketol-acid reductoisomerase YP_002344061.1 594548 D 192222 CDS YP_002344062.1 218562283 904962 595574..596656 1 NC_002163.1 Original (2000) note: Cj0633, probable periplasmic protein, len: 360 aa; similar in C-terminus to hypothetical proteins e.g. TR:O51711 (EMBL:AE001176) Borrelia burgdorferi BB0770 (293 aa), fasta scores; opt: 425 z-score: 553.2 E(): 1.6e-23, 36.3% identity in 237 aa overlap. No Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF04748 Divergent polysaccharide deacetylase identified within CDS. No specific characterisation has been carried out yet. Product function unchanged. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 596656 904962 Cj0633 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344062.1 595574 D 192222 CDS YP_002344063.1 218562284 904964 596646..597419 1 NC_002163.1 Original (2000) note: Cj0634, unknown, len: 257 aa; similar, in part, to members of the SMF family e.g. SMF_HAEIN SMF protein (DNA processing chain A) (373 aa),fasta scores; opt: 329 z-score: 487.6 E(): 7.2e-20, 31.5% identity in 213 aa overlap. 48.8% identity to HP0333; Updated (2006) note: Pfam domain PF02481 SMF family identified within CDS. Further support given to product function. Literature search identified Campylobacter jejuni characterising paper. Product modified to more specific family member. Functional classification - DNA replication, restriction/modification, recombination and repair; PMID:16194595; DNA processing protein A 597419 dprA 904964 dprA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA processing protein A YP_002344063.1 596646 D 192222 CDS YP_002344064.1 218562285 904965 597416..597799 1 NC_002163.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 597799 904965 Cj0635 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Holliday junction resolvase-like protein YP_002344064.1 597416 D 192222 CDS YP_002344065.1 218562286 904966 597828..598667 1 NC_002163.1 Original (2000) note: Cj0636, unknown, len: 279 aa; similar to members of the NOL1/NOP2/sun family e.g. Y026_METJA MJ0026 (274 aa), fasta scores; opt: 422 z-score: 688.4 E(): 4.8e-31, 33.9% identity in 280 aa overlap. No Hp match. Contains Pfam match to entry PF01189 Nol1_Nop2_Sun, NOL1/NOP2/sun family. Functional classification - Conserved hypothetical proteins; NOL1/NOP2/sun family protein 598667 904966 Cj0636 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NOL1/NOP2/sun family protein YP_002344065.1 597828 D 192222 CDS YP_002344066.1 218562287 904967 complement(598843..599340) 1 NC_002163.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 599340 mrsA 904967 mrsA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methionine sulfoxide reductase A YP_002344066.1 598843 R 192222 CDS YP_002344067.1 218562288 904968 complement(599381..599899) 1 NC_002163.1 Original (2000) note: Cj0638c, ppa, probable inorganic pyrophosphatase, len: 172 aa; highly similar to many e.g. IPYR_ECOLI inorganic pyrophosphatase (EC 3.6.1.1) (175 aa), fasta scores; opt: 564 z-score: 990.9 E(): 0, 54.0% identity in 161 aa overlap. 59.3% identity to HP0620. Contains PS00387 Inorganic pyrophosphatase signature and Pfam match to entry PF00719 Pyrophosphatase,Inorganic pyrophosphatase; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. not added to product function. Literature search identified paper linking protein to glycoprotein (PMID:12186869). Functional classification - Central intermediary metabolism - General; PMID:12186869, PMID:2848015, PMID:9201917; inorganic pyrophosphatase 599899 ppa 904968 ppa Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 inorganic pyrophosphatase YP_002344067.1 599381 R 192222 CDS YP_002344068.1 218562289 904969 complement(599909..600487) 1 NC_002163.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 600487 adk 904969 adk Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 adenylate kinase YP_002344068.1 599909 R 192222 CDS YP_002344069.1 218562290 904820 complement(600484..602235) 1 NC_002163.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 602235 aspS 904820 aspS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aspartyl-tRNA synthetase YP_002344069.1 600484 R 192222 CDS YP_002344070.1 218562291 905135 602326..603186 1 NC_002163.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 603186 pnk 905135 pnk Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 inorganic polyphosphate/ATP-NAD kinase YP_002344070.1 602326 D 192222 CDS YP_002344071.1 218562292 905122 603186..604709 1 NC_002163.1 Original (2000) note: Cj0642, recN, possible DNA repair protein, len: 507 aa; some similarity to e.g. RECN_BACSU DNA repair protein RECN (576 aa), fasta scores; opt: 272 z-score: 353.1 E(): 2.3e-12, 24.5% identity in 559 aa overlap. 36.1% identity to HP1393. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Characterised within Bacillus subtilis, however, identity score was unnacceptable. kept within product function. Functional classification - DNA replication,restriction/modification, recombination and repair; PMID:9044256; DNA repair protein 604709 recN 905122 recN Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA repair protein YP_002344071.1 603186 D 192222 CDS YP_002344072.1 218562293 904970 604815..606059 1 NC_002163.1 Original (2000) note: Cj0643, probable two-component response regulator, len: 414 aa; similar to e.g. TR:P97018 (EMBL:U67070) Aeromonas jandaei response regulator protein RRPX (415 aa), fasta scores; opt: 597 z-score: 530.0 E(): 3.2e-22, 25.8% identity in 414 aa overlap, andTR:Q46020 (EMBL:L42554) Caulobacter crescentus response regulator PLED (454 aa), fasta scores; opt: 286 z-score: 309.9 E(): 5.8e-10, 22.0% identity in 451 aa overlap. No Hp ortholog. Contains 2x Pfam match to entry PF00072 response_reg, Response regulator receiver domain and Pfam match to entry PF00990 DUF9, Domain of unknown function; Updated (2006) note: Pfam domain PF00990 has now been annotated as GGDEF domain that often happens to be linked to a regulatory domain. Further support given to product function. Literature search identified paper characterising Cj0643 and confirming it as a two-component response regulator and is designated as CbrR (Campylobacter bile resistance Regulator) protein. Functional classification - Signal transduction; PMID:15901688; two-component response regulator 606059 cbrR 904970 cbrR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 two-component response regulator YP_002344072.1 604815 D 192222 CDS YP_002344073.1 218562294 904971 606050..606865 1 NC_002163.1 Original (2000) note: Cj0644, unknown, len: 271 aa; similar to hypothetical proteins e.g. YABD_BACSU (255 aa),fasta scores; opt: 614 z-score: 1024.7 E(): 0, 38.6% identity in 259 aa overlap. 49.2% identity to HP1573. Contains PS01137 Uncharacterized protein family UPF0006 signature 1 and Pfam match to entry PF01026 UPF0006,Uncharacterized protein family; Updated (2006) note: Pfam domain PF01026 TatD related DNase and Prosite domain PS01137 TATD_1,TatD-related deoxyribonuclease were identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation carried out yet. kept within product function. Functional classification - Misc; TatD-related deoxyribonuclease 606865 904971 Cj0644 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 TatD-related deoxyribonuclease YP_002344073.1 606050 D 192222 CDS YP_002344074.1 218562295 904972 606865..607983 1 NC_002163.1 Original (2000) note: Cj0645, possible secreted transglycosylase, len: 372 aa; similar to members of the SLT family e.g. MLTD_ECOLI membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-) (452 aa), fasta scores; opt: 425 z-score: 431.3 E(): 1e-16, 28.4% identity in 348 aa overlap. 37.5% identity to HP1572. Contains N-terminal signal sequence; Updated (2006) note: Pfam domains PF01464 Transglycosylase SLT domain PF01476 LysM domain were identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score and only partial alignment. kept within product function. Functional classification - Murein sacculus and peptidoglycan; PMID:10843862; secreted transglycosylase 607983 904972 Cj0645 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 secreted transglycosylase YP_002344074.1 606865 D 192222 CDS YP_002344075.1 218562296 904973 607943..608770 1 NC_002163.1 Original (2000) note: Cj0646, probable lipoprotein,len: 275 aa; similar to e.g. RLPA_ECOLI rare lipoprotein A precursor (362 aa), fasta scores; opt: 251 z-score: 431.7 E(): 9.4e-17, 33.6% identity in 131 aa overlap. 50.2% identity to HP1571. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Pfam domain PF03330 Rare lipoprotein A (RlpA)-like double-psi beta-barrel was identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification - Membranes, lipoproteins and porins; lipoprotein 608770 904973 Cj0646 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002344075.1 607943 D 192222 CDS YP_002344076.1 218562297 904974 608776..609264 1 NC_002163.1 Original (2000) note: Cj0647, unknown, len: 162 aa; similar to hypothetical proteins e.g. YRBI_ECOLI (188 aa), fasta scores; opt: 322 z-score: 399.6 E(): 5.8e-15,40.0% identity in 155 aa overlap. 40.9% identity to HP1570; Updated (2006) note: Pfam domain PF08282 haloacid dehalogenase-like hydrolase was identified by running own search within CDS. Product modified to more specific family member due to motif match. No specific characterisation carried out yet. kept within product function. Some similarity to recently characterised Escherichia coli 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase, KdsC, however, alignment was only partial. Functional classification - Misc; PMID:12639950; HAD-superfamily hydrolase 609264 904974 Cj0647 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 HAD-superfamily hydrolase YP_002344076.1 608776 D 192222 CDS YP_002344077.1 218562298 904975 609255..609770 1 NC_002163.1 Original (2000) note: Cj0648, unknwn, len: 171 aa; no Hp match; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Also, one N-terminal signal peptide predicted by SignalP 2.0 HMM. Product function modified to more specific family member. kept within product function. Functional classification -Membranes, lipoproteins and porins; hypothetical protein 609770 904975 Cj0648 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344077.1 609255 D 192222 CDS YP_002344078.1 218562299 904976 609752..610213 1 NC_002163.1 Original (2000) note: Cj0649, unknown, len: 153 aa; 31.6% identity to HP1568; Updated (2006) note: Pfam domain PF03968 OstA-like protein was identified within CDS. Product modified to more specific family member due to Pfam match. No specific characterisation has been carried out. kept within product function. Functional classification -Conserved hypothetical proteins; PMID:7811102; OstA family protein 610213 904976 Cj0649 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 OstA family protein YP_002344078.1 609752 D 192222 CDS YP_002344079.1 218562300 904977 610210..610806 1 NC_002163.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 610806 engB 904977 engB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribosome biogenesis GTP-binding protein YsxC YP_002344079.1 610210 D 192222 CDS YP_002344080.1 218562301 904978 610803..611297 1 NC_002163.1 Original (2000) note: Cj0651, possible integral membrane protein, len: 164 aa; no Hp match; Updated (2006) note: Five probable transmembrane helices predicted by TMHMM2.0 identified within CDS. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 611297 904978 Cj0651 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344080.1 610803 D 192222 CDS YP_002344081.1 218562302 904979 611298..613103 1 NC_002163.1 Original (2000) note: Cj0652, pbpC, probable penicillin-binding protein, len: 601 aa; similar to many e.g. PBP2_ECOLI penicillin-binding protein 2 (PBP-2) (633 aa), fasta scores; opt: 954 z-score: 1474.4 E(): 0, 32.7% identity in 609 aa overlap. 43.5% identity to HP1565. Contains Pfam match to entry PF00905 Transpeptidase,Penicillin binding protein transpeptidase domain; Updated (2006) note: Pfam domain PF03717 Penicillin-binding Protein dimerisation domain was identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score. not added to product function. Functional classification - Murein sacculus and peptidoglycan; PMID:9045804; penicillin-binding protein 613103 pbpC 904979 pbpC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 penicillin-binding protein YP_002344081.1 611298 D 192222 CDS YP_002344082.1 218562303 904980 complement(613224..615014) 1 NC_002163.1 Original (2000) note: Cj0653c, probable aminopeptidase, len: 596 aa; similar to e.g. TR:O54975 (EMBL:AF038591) rattus norvegicus cytoplasmic aminopeptidase P (623 aa), fasta scores; opt: 763 z-score: 1470.5 E(): 0, 36.8% identity in 612 aa overlap, and TR:O51094 (EMBL:AE001119) Borrelia burgdorferi peptidase BB0067 (592 aa), fasta scores; opt: 1234 z-score: 1316.7 E(): 0, 41.1% identity in 609 aa overlap. 25.8% identity to HP1037. Contains Pfam match to entry PF00557 pep_M24, metallopeptidase family M24; Updated (2006) note: No specific characterisation with acceptable identity scores carried out yet. kept within product function. Functional classification -Degradation of macromolecules - Proteins, peptides and glycopeptides; aminopeptidase 615014 904980 Cj0653c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aminopeptidase YP_002344082.1 613224 R 192222 CDS YP_002344083.1 218562304 904910 complement(616572..617120) 1 NC_002163.1 Original (2000) note: Cj0659c, possible periplasmic protein, len: 182 aa; no Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: One probable transmembrane helices predicted by TMHMM2.0 identified within CDS. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 617120 904910 Cj0659c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344083.1 616572 R 192222 CDS YP_002344084.1 218562305 904982 complement(617113..618219) 1 NC_002163.1 Original (2000) note: Cj0660c, possible transmembrane protein, len: 368 aa; no Hp match. Contains a possible transmembrane domain around aa 220; Updated (2006) note: One probable transmembrane helices predicted by TMHMM2.0 identified within CDS. Functional classification - Membranes, lipoproteins and porins; transmembrane protein 618219 904982 Cj0660c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transmembrane protein YP_002344084.1 617113 R 192222 CDS YP_002344085.1 218562306 904983 complement(618206..619081) 1 NC_002163.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 619081 era 904983 era Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GTP-binding protein Era YP_002344085.1 618206 R 192222 CDS YP_002344086.1 218562307 904984 complement(619078..620397) 1 NC_002163.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 620397 hslU 904984 hslU Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP-dependent protease ATP-binding subunit HslU YP_002344086.1 619078 R 192222 CDS YP_002344087.1 218562308 904986 complement(620394..620936) 1 NC_002163.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 620936 hslV 904986 hslV Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP-dependent protease peptidase subunit YP_002344087.1 620394 R 192222 CDS YP_002344088.1 218562309 904987 complement(620936..621379) 1 NC_002163.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 621379 rplI 904987 rplI Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L9 YP_002344088.1 620936 R 192222 CDS YP_002344089.1 218562310 904988 complement(621392..622612) 1 NC_002163.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 622612 argG 904988 argG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 argininosuccinate synthase YP_002344089.1 621392 R 192222 CDS YP_002344090.1 218562311 904989 622768..623013 1 NC_002163.1 Original (2000) note: Cj0667, unknown, len: 81 aa; similar to many hypothetical proteins e.g. YABO_BACSU (86 aa), fasta scores; opt: 149 z-score: 259.2 E(): 3.8e-07,35.4% identity in 79 aa overlap. 43.6% identity to HP1423; Updated (2006) note: Pfam domain PF01479 S4 domain was identified within CDS. The S4 domain probably mediates binding to RNA. Product modified to more specific family member due to motif match. No specific characterisation has been carried out. kept within product function. Functional classification - Misc; S4 domain protein 623013 904989 Cj0667 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 S4 domain protein YP_002344090.1 622768 D 192222 CDS YP_002344091.1 218562312 904990 623010..623417 1 NC_002163.1 Original (2000) note: Cj0668, probable ATP/GTP-binding protein, len: 135 aa; similar to hypothetical proteins e.g. YJEE_ECOLI (153 aa), fasta scores; opt: 164 z-score: 205.3 E(): 0.00039, 33.8% identity in 80 aa overlap. 44.2% identity to HP0716. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Pfam domain PF02367 Uncharacterised P-loop hydrolase UPF0079 was identified within CDS. No specific characterisation has been carried out yet. kept within product function. Functional classification - Conserved hypothetical proteins; ATP/GTP-binding protein 623417 904990 Cj0668 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP/GTP-binding protein YP_002344091.1 623010 D 192222 CDS YP_002344092.1 218562313 905196 623410..624138 1 NC_002163.1 Original (2000) note: Cj0669, probable ABC-transporter ATP-binding protein, len: 242 aa; highly similar to many e.g. YHBG_ECOLI probable ABC transporter ATP-binding protein (240 aa), fasta scores; opt: 840 z-score: 1144.2 E(): 0, 54.2% identity in 236 aa overlap. 65.8% identity to HP0715. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry PF00005 ABC_tran, ABC transporters; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Appropriate motifs also present. not added to product function. Functional classification -Transport/binding proteins - Other; PMID:16079137; ABC-transporter ATP-binding protein 624138 905196 Cj0669 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC-transporter ATP-binding protein YP_002344092.1 623410 D 192222 CDS YP_002344093.1 218562314 904991 624138..625388 1 NC_002163.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 625388 rpoN 904991 rpoN Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 RNA polymerase factor sigma-54 YP_002344093.1 624138 D 192222 CDS YP_002344094.1 218562315 904992 625552..626976 1 NC_002163.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 626976 dcuB 904992 dcuB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 anaerobic C4-dicarboxylate transporter YP_002344094.1 625552 D 192222 CDS YP_002344095.1 218562316 904993 627118..627306 1 NC_002163.1 Original (2000) note: Cj0672, possible periplasmic protein, len: 62 aa; no Hp match. Contains possible N-terminal signal sequence and second hydrophobic domain; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 627306 904993 Cj0672 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344095.1 627118 D 192222 CDS YP_002344096.1 218562317 904995 629020..631065 1 NC_002163.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 631065 kdpB 904995 kdpB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 potassium-transporting ATPase subunit B YP_002344096.1 629020 D 192222 CDS YP_002344097.1 218562318 904997 631667..633487 1 NC_002163.1 Original (2000) note: Cj0679, kdpD', truncated KdpD protein, len: 606 aa; similar to other kdpD sensor proteins, but lacking the C-terminal two-component histidine kinase domain, e.g. KDPD_ECOLI sensor protein KDPD (EC 2.7.3.-) (894 aa), fasta scores; opt: 883 z-score: 1523.9 E(): 0, 34.8% identity in 604 aa overlap. No Hp match. Note that C. jejuni apparently lacks a kdpE two-component regulator homolog; Updated (2006) note: Pfam domain PF02702 Osmosensitive K+ channel His kinase sensor domain was identified within CDS. Five probable transmembrane helices predicted by TMHMM2.0. Further support for product function. not added to product function. Functional classification - Transport/binding proteins -Cations; PMID:9226259, PMID:7499326, PMID:1532388; truncated KdpD protein 633487 kdpD 904997 kdpD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 truncated KdpD protein YP_002344097.1 631667 D 192222 CDS YP_002344098.1 218562319 904998 complement(633589..635562) 1 NC_002163.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 635562 uvrB 904998 uvrB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 excinuclease ABC subunit B YP_002344098.1 633589 R 192222 CDS YP_002344099.1 218562320 904999 635716..635946 1 NC_002163.1 Original (2000) note: Cj0681, unknown, len: 76 aa; 36.2% identity to HP0385. Functional classification -Conserved hypothetical proteins; hypothetical protein 635946 904999 Cj0681 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344099.1 635716 D 192222 CDS YP_002344100.1 218562321 905000 635936..636178 1 NC_002163.1 Original (2000) note: Cj0682, unknown, len: 80 aa; no Hp match. Functional classification - Unknown; hypothetical protein 636178 905000 Cj0682 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344100.1 635936 D 192222 CDS YP_002344101.1 218562322 905001 636175..636612 1 NC_002163.1 Original (2000) note: Cj0683, probable periplasmic protein, len: 145 aa; no Hp match; Updated (2006) note: One probable transmembrane helices predicted by TMHMM2.0. Further support for product function. Pfam domain PF07963 Prokaryotic N-terminal methylation motif was identified within CDS. The motif is involved in methylation and is said to be found at the N-terminus of pilins and other proteins involved in secretion. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 636612 905001 Cj0683 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344101.1 636175 D 192222 CDS YP_002344102.1 218562323 905002 636594..638447 1 NC_002163.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 638447 priA 905002 priA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 primosome assembly protein PriA YP_002344102.1 636594 D 192222 CDS YP_002344103.1 218562324 905003 complement(638540..639892) 1 NC_002163.1 Original (2000) note: Cj0685c, possible sugar transferase, len: 450 aa; no Hp match. Contains variable poly-G tract near C-terminus; G9 (consensus) allows complete translation, G10 would cause truncation at aa 233. Some similarity to Cj1421c (28.0% identity in 404 aa overlap) and Cj1422c (25.3% identity in 442 aa overlap),both of which contain variable polyG tracts, though in different positions. functional assignment is based on family clustering (BLASTP) with other C. jejuni predicted sugar transferases e,g, Cj1434c, and Cj1438c; Updated (2006) note: No specific characterisation carried out yet. kept within product function. Original and updated annotation kept designation as sugar transferase. This gene has now been patented as encoding invasion protein of Campylobacter species. Also, work has been carried out within a PhD thesis. Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; http://www.freepatentsonline.com/6087105.html; http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_ 0004/MQ46044.pdf#search=%22cipA%20AND%20campylobacter%22; invasion protein CipA 639892 cipA 905003 cipA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 invasion protein CipA YP_002344103.1 638540 R 192222 CDS YP_002344104.1 218562325 905004 639998..641071 1 NC_002163.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 641071 ispG 905004 ispG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_002344104.1 639998 D 192222 CDS YP_002344105.1 218562326 905006 complement(641102..641800) 1 NC_002163.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 641800 flgH 905006 flgH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar basal body L-ring protein YP_002344105.1 641102 R 192222 CDS YP_002344106.1 218562327 905007 641890..643395 1 NC_002163.1 Original (2000) note: Cj0688, pta, probable phosphate acetyltransferase, len: 501 aa; highly similar in C-terminus to e.g. PTA_ECOLI phosphate acetyltransferase (EC 2.3.1.8) (713 aa), fasta scores; opt: 1012 z-score: 1161.8 E(): 0, 48.8% identity in 326 aa overlap. 24.8% identity in N-terminus to HP0905; Updated (2006) note: Pfam domain PF01515 Phosphate acetyl/butaryl transferase was identified within CDS. Further support given to product function. Characterised within Escherichia coli with acceptable identity score,however, sequence alignment was only partial. kept within product function. Literature search identified paper linking product function to biofilm formation (PMID:16436427). Functional classification - Degradation -Carbon compounds; PMID:16436427, PMID:7883769; phosphate acetyltransferase 643395 pta 905007 pta Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphate acetyltransferase YP_002344106.1 641890 D 192222 CDS YP_002344107.1 218562328 905008 643409..644599 1 NC_002163.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 644599 ackA 905008 ackA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetate kinase YP_002344107.1 643409 D 192222 CDS YP_002344108.1 218562329 905009 complement(644627..648379) 1 NC_002163.1 Original (2000) note: Cj0690c, possible restriction/modification enzyme, len: 1250 aa; similar to Borrelia burgdorferi plasmid TR:O50698 (EMBL:AE000785) hypotheticalprotein BBE02 (1277 aa), fasta scores; opt: 1517 z-score: 1607.6 E(): 0, 35.0% identity in 1304 aa overlap. Very weak similarity to T257_ECOLI type IIS restriction enzyme ECO57I (997 aa), fasta scores; opt: 156 z-score: 163.4 E(): 0.083, 19.6% identity in 981 aa overlap. No Hp ortholog. Some simlarity to Cj0031 (25.0% identity in 859 aa overlap). Contains PS00092 N-6 Adenine-specific DNA methylases signature; Updated (2006) note: Pfam domain PF04313 Type I restriction enzyme R protein N terminal was identified within CDS. Further support given to product function. Probable replaced with . Product function modified to more specific family member based on motif match. No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification - DNA replication,restriction/modification, recombination and repair; restriction/modification enzyme 648379 905009 Cj0690c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 restriction/modification enzyme YP_002344108.1 644627 R 192222 CDS YP_002344109.1 218562330 905010 648529..649020 1 NC_002163.1 Original (2000) note: Cj0691, possible membrane protein, len: 163 aa; no Hp match. Contains two possible transmembrane domains. Functional classification -Membranes, lipoproteins and porins; hypothetical protein 649020 905010 Cj0691 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344109.1 648529 D 192222 CDS YP_002344110.1 218562331 905011 complement(649008..649946) 1 NC_002163.1 Original (2000) note: Cj0692c, possible membrane protein, len: 312 aa; 34.7% identity in N-terminus to HP0708 (114 aa). Contains one possible transmembrane domain. Functional classification - Membranes,lipoproteins and porins; hypothetical protein 649946 905011 Cj0692c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344110.1 649008 R 192222 CDS YP_002344111.1 218562332 905012 complement(649946..650884) 1 NC_002163.1 Original (2000) note: Cj0693c, unknown, len: 312 aa; similar to members of the YABC/YLXA family of hypothetical proteins e.g. YLXA_BACSU (311 aa), fasta scores; opt: 584 z-score: 670.8 E(): 4.6e-30, 39.8% identity in 304 aa overlap. 47.4% identity to HP0707; Updated (2006) note: Pfam domain PF01795 MraW methylase family was identified within CDS. Characterised within Escherichia coli with marginal identity score. Product modified to more specific family member based on motif and characterisation. not added to product function. EC number and gene name added. Functional classification - Aminoacyl tRNA synthetases and their modification; PMID:10572301; S-adenosyl-methyltransferase MraW 650884 mraW 905012 mraW Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 S-adenosyl-methyltransferase MraW YP_002344111.1 649946 R 192222 CDS YP_002344112.1 218562333 905013 651043..652533 1 NC_002163.1 Original (2000) note: Cj0694, probable periplasmic protein, len: 496 aa; C-terminus is almost identical to C. jejuni ORF TR:Q46115 (EMBL:X95910). 31.9% identity toHP0977. Contains probable N-terminal signal sequence; Updated (2006) note: Literature search identified paper linking product function to glycoprotein. Functional classification - Miscellaneous periplasmic proteins; PMID:12186869; periplasmic protein 652533 905013 Cj0694 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344112.1 651043 D 192222 CDS YP_002344113.1 218562334 905014 652530..653918 1 NC_002163.1 Original (2000) note: Cj0695, ftsA, probable cell division protein, len: 462; identical, except for a small frameshift, to C. jejuni ftsA TR:Q46116 (EMBL:X95910). Similar to many e.g. FTSA_ECOLI cell division protein FTSA (420 aa), fasta scores; opt: 570 z-score: 635.2 E(): 4.4e-28, 27.7% identity in 382 aa overlap. 37.2% identity to HP0978; Updated (2006) note: Pfam domains PF02491 (x2) Cell division protein FtsA were identified within CDS. Further support given to product function. Characterisation work has been carried out within Campylobacter jejuni. not added to product function. Functional classification -Cell division; PMID:8807806; cell division protein FtsA 653918 ftsA 905014 ftsA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cell division protein FtsA YP_002344113.1 652530 D 192222 CDS YP_002344114.1 218562335 905015 653934..655046 1 NC_002163.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 655046 ftsZ 905015 ftsZ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cell division protein FtsZ YP_002344114.1 653934 D 192222 CDS YP_002344115.1 218562336 905016 655202..656014 1 NC_002163.1 Original (2000) note: Cj0697, flgG2, probable flagellar basal-body rod protein, len: 270 aa; similar to e.g. FLGG_ECOLI flagellar basal-body rod protein FLGG (260 aa), fasta scores; opt: 290 z-score: 318.7 E(): 1.9e-10,28.7% identity in 272 aa overlap. 42.6% identity to HP1092. Also similar to downstream gene Cj0698 (flgG,29.9% identity in 281 aa overlap). Contains PS00588 Flagella basal body rod proteins signature and Pfam match to entry PF00460 flg_bb_rod, Flagella basal body rod proteins; Updated (2006) note: Characterised within Escherichia coli with marginal identity score. Also,characterisation work within Campylobacter jejuni. removed from product function. Functional classification - Surface structures; PMID:9931471, PMID:15228533; flagellar basal-body rod protein 656014 flgG2 905016 flgG2 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar basal-body rod protein YP_002344115.1 655202 D 192222 CDS YP_002344116.1 218562337 905017 656043..656834 1 NC_002163.1 makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 656834 flgG 905017 flgG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar basal body rod protein FlgG YP_002344116.1 656043 D 192222 CDS YP_002344117.1 218562338 905018 complement(656901..658331) 1 NC_002163.1 Original (2000) note: Cj0699c, glnA, probable glutamine synthetase, len: 476 aa; highly similar to many e.g. GLNA_ECOLI glutamine synthetase (EC 6.3.1.2) (468 aa), fasta scores; opt: 1529 z-score: 1812.8 E(): 0,51.5% identity in 462 aa overlap. 63.6% identity to HP0512. Contains PS00180 Glutamine synthetase signature 1,PS00181 Glutamine synthetase ATP-binding region signature, and Pfam match to entry PF00120 gln-synt; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Amino acid biosynthesis - Glutamate family; PMID:2882477; glutamine synthetase 658331 glnA 905018 glnA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glutamine synthetase YP_002344117.1 656901 R 192222 CDS YP_002344118.1 218562339 905019 658534..659229 1 NC_002163.1 Original (2000) note: Cj0700, unknown, len: 231 aa; 49.4% identity to HP0170. Functional classification -Conserved hypothetical proteins; hypothetical protein 659229 905019 Cj0700 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344118.1 658534 D 192222 CDS YP_002344119.1 218562340 905020 659226..660479 1 NC_002163.1 Original (2000) note: Cj0701, probable protease,len: 417 aa; similar to many proteases belonging to the peptidase family U32, e.g. YEGQ_ECOLI protease in baer-ogrk intergenic Region (453 aa), fasta scores; opt: 567 z-score: 648.6 E(): 7.9e-29, 34.9% identity in 404 aa overlap. 55.5% identity to HP0169. Contains PS01276 Peptidase family U32 signature and Pfam match to entry PF01136 Peptidase_U32; Updated (2006) note: Similar to many with marginal identity scores. kept within product function. Functional classification - Degradation of macromolecules - Proteins, peptides and glycopeptides; protease 660479 905020 Cj0701 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 protease YP_002344119.1 659226 D 192222 CDS YP_002344120.1 218562341 905021 660480..660974 1 NC_002163.1 Original (2000) note: Cj0702, purE, probable phosphoribosylaminoimidazole carboxylase catalytic subunit, len: 164 aa; similar to many e.g. PUR6_ECOLI phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21) (168 aa), fasta scores; opt: 485 z-score: 562.6 E(): 4.9e-24, 55.2% identity in 143 aa overlap. No Hp match. Contains Pfam match to entry PF00731 AIRC, AIR carboxylase; Updated (2006) note: Characterised within Escherichia coli and Bacillus subtilus with acceptable identity scores. not added to product function. Functional classification - Purine ribonucleotide biosynthesis; PMID:10074353, PMID:2464576; phosphoribosylaminoimidazole carboxylase catalytic subunit 660974 purE 905021 purE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoribosylaminoimidazole carboxylase catalytic subunit YP_002344120.1 660480 D 192222 CDS YP_002344121.1 218562342 905022 660984..661520 1 NC_002163.1 Original (2000) note: Cj0703, unknown, len: 178 aa; 51.0% identity to HP0406. Functional classification -Conserved hypothetical proteins; hypothetical protein 661520 905022 Cj0703 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344121.1 660984 D 192222 CDS YP_002344122.1 218562343 905023 661532..662395 1 NC_002163.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 662395 glyQ 905023 glyQ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glycyl-tRNA synthetase subunit alpha YP_002344122.1 661532 D 192222 CDS YP_002344123.1 218562344 905024 662382..663107 1 NC_002163.1 Original (2000) note: Cj0705, unknown, len: 241 aa; similar to hypothetical proteins e.g. TR:O51424 (EMBL:AE001151) Borrelia burgdorferi BB0468 (248 aa),fasta scores; opt: 240 z-score: 292.4 E(): 5.5e-09, 27.0% identity in 244 aa overlap. 42.7% identity to HP0959; Updated (2006) note: Pfam domain PF01784 NIF3 (NGG1p interacting factor 3) identified within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 663107 905024 Cj0705 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344123.1 662382 D 192222 CDS YP_002344124.1 218562345 905025 663117..663833 1 NC_002163.1 Original (2000) note: Cj0706, unknown, len: 238 aa; similar to hypothetical proteins e.g. TR:O67273 (EMBL:AE000729) Aquifex aeolicus AQ_1223 (235 aa), fasta scores; opt: 298 z-score: 287.3 E(): 1.1e-08, 30.1% identity in 236 aa overlap. 37.4% identity to HP0958; Updated (2006) note: Pfam domain PF02591 Uncharacterized ACR, COG1579 identified within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 663833 905025 Cj0706 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344124.1 663117 D 192222 CDS YP_002344125.1 218562346 905026 663830..664987 1 NC_002163.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 664987 kdtA 905026 kdtA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 3-deoxy-D-manno-octulosonic-acid transferase YP_002344125.1 663830 D 192222 CDS YP_002344126.1 218562347 905027 664968..665720 1 NC_002163.1 Original (2000) note: Cj0708, possible ribosomal pseudouridine synthase, len: 250 aa; similar to many hypothetical proteins and to e.g. RLUC_ECOLI ribosomal large subunit pseudouridine synthase D (EC 4.2.1.70) (319 aa), fasta scores; opt: 202 z-score: 252.9 E(): 8.6e-07,29.7% identity in 175 aa overlap. 47.0% identity to HP0956. Contains PS01129 Hypothetical yabO/yceC/sfhB family signature and Pfam match to entry PF00849 YABO,Hypothetical yabO/yceC/sfhB family. Also similar to Cj1280c (26.9% identity in 223 aa overlap) and Cj0022c (27.6% identity in 275 aa overlap); Updated (2006) note: Pfam domain now updated to RNA pseudouridylate synthase. No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification -Ribosome maturation and modification; PMID:10089432; ribosomal pseudouridine synthase 665720 905027 Cj0708 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribosomal pseudouridine synthase YP_002344126.1 664968 D 192222 CDS YP_002344127.1 218562348 905028 665788..667125 1 NC_002163.1 Original (2000) note: Cj0709, ffh, probable signal recognition particle protein, len: 445 aa; highly similar to many e.g. SR54_ECOLI signal recognition particle protein (453 aa), fasta scores; opt: 1136 z-score: 1195.2 E(): 0, 41.5% identity in 441 aa overlap. 61.0% identity to HP1152. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00300 SRP54-type proteins GTP-binding domain signature, and Pfam match to entry PF00448 SRP54,SRP54-type protein; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Protein and peptide secretion; PMID:1331806, PMID:11976293; signal recognition particle protein 667125 ffh 905028 ffh Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 signal recognition particle protein YP_002344127.1 665788 D 192222 CDS YP_002344128.1 218562349 905030 667190..667417 1 NC_002163.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 667417 rpsP 905030 rpsP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S16 YP_002344128.1 667190 D 192222 CDS YP_002344129.1 218562350 904497 667420..667662 1 NC_002163.1 Original (2000) note: Cj0711, unknown, len: 80 aa; simlar to small hypothetical proteins downstream of rpsP in many organisms e.g. TR:O31738 (EMBL:Z99112) Bacillus subtilis YLQC (81 aa), fasta scores; opt: 115 z-score: 178.5 E(): 0.012, 32.3% identity in 62 aa overlap. 37.7% identity to HP1150. Functional classification - Conserved hypothetical proteins; hypothetical protein 667662 904497 Cj0711 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344129.1 667420 D 192222 CDS YP_002344130.1 218562351 904519 667655..668194 1 NC_002163.1 Original (2000) note: Cj0712, rimM, possible 16S rRNA processing protein, len: 179 aa; similar to e.g. RIMM_ECOLI 16S rRNA processing protein RIMM (185 aa),fasta scores; opt: 202 z-score: 255.1 E(): 6.6e-07, 24.1% identity in 174 aa overlap. 37.8% identity to HP1149; Updated (2006) note: Pfam domains PF01782 RimM N-terminal domain and PF05239 PRC-barrel domain were identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score. kept within product function. Functional classification - Ribosome maturation and modification; PMID:9422595; 16S rRNA processing protein 668194 rimM 904519 rimM Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 16S rRNA processing protein YP_002344130.1 667655 D 192222 CDS YP_002344131.1 218562352 904477 668191..668895 1 NC_002163.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 668895 trmD 904477 trmD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tRNA (guanine-N(1)-)-methyltransferase YP_002344131.1 668191 D 192222 CDS YP_002344132.1 218562353 905031 668906..669262 1 NC_002163.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 669262 rplS 905031 rplS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L19 YP_002344132.1 668906 D 192222 CDS YP_002344133.1 218562354 905032 669395..669808 1 NC_002163.1 Original (2000) note: Cj0715, transthyretin-like periplasmic protein, len: 137 aa; similar to members of the transthyretin family e.g. YEDX_ECOLI hypothetical transthyretin-like protein precursor (137 aa), fasta scores; opt: 305 z-score: 409.7 E(): 1.6e-15, 38.9% identity in 126 aa overlap, and TTHY_BOVIN Cow transthyretin precursor (prealbumin) (147 aa), fasta scores; opt: 205 z-score: 279.8 E(): 2.8e-08, 33.8% identity in 142 aa overlap. No Hp match. Contains Pfam match to entry PF00576 Transthyretin and probable N-terminal signal sequence; Updated (2006) note: Prosite domains PS00768 TRANSTHYRETIN_1, Transthyretin and PS00769 TRANSTHYRETIN_2, Transthyretin were identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet. Product function unchanged. Functional classification - Miscellaneous periplasmic proteins; PMID:12186869; transthyretin-like periplasmic protein 669808 905032 Cj0715 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transthyretin-like periplasmic protein YP_002344133.1 669395 D 192222 CDS YP_002344134.1 218562355 905033 669832..671172 1 NC_002163.1 Original (2000) note: Cj0716, probable phospho-2-dehydro-3-deoxyheptonate aldolase, len: 446 aa; similar to enzymes from plants e.g. AROF_ARATH phospho-2-dehydro-3-deoxyheptonate aldolase (EC 4.1.2.15) (525 aa), fasta scores; opt: 1680 z-score: 1935.9 E(): 0,54.2% identity in 445 aa overlap. 59.6% identity to HP0134; Updated (2006) note: Pfam domain PF01474 Class-II DAHP synthetase family identified within CDS. Product function kept the same (along with ), as no specific characterisation within related bacteria has been carried out. Functional classification - Amino acid biosynthesis - Aromatic amino acid family; phospho-2-dehydro-3-deoxyheptonate aldolase 671172 905033 Cj0716 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002344134.1 669832 D 192222 CDS YP_002344135.1 218562356 905035 671169..671498 1 NC_002163.1 Original (2000) note: Cj0717, unknown, len: aa; similar to hypothetical proteins e.g. YFFB_ECOLI (118 aa),fasta scores; opt: 164 z-score: 215.8 E(): 0.0001, 32.3% identity in 93 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03960 ArsC family identified within CDS. Product modified to more specific family member due to motif match. ArsC is thought to catalyze the reduction of arsenate to arsenite. No specific characterisation has been carried out. kept within product function. Functional classification -Misc; PMID:1704144; ArsC family protein 671498 905035 Cj0717 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ArsC family protein YP_002344135.1 671169 D 192222 CDS YP_002344136.1 218562357 905036 671946..675548 1 NC_002163.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 675548 dnaE 905036 dnaE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA polymerase III subunit alpha YP_002344136.1 671946 D 192222 CDS YP_002344137.1 218562358 905037 complement(675560..676192) 1 NC_002163.1 Original (2000) note: Cj0719c, unknown, len: 210 aa; similar to hypothetical proteins from many organisms e.g. YGGS_ECOLI (234 aa), fasta scores; opt: 307 z-score: 380.4 E(): 6.9e-14, 34.0% identity in 206 aa overlap. 47.5% identity to HP0395. Contains PS01211 Uncharacterized protein family UPF0001 signature and Pfam match to entry PF01168 UPF0001; Updated (2006) note: Pfam domain PF01168 Alanine racemase, N-terminal domain identified within CDS. This is an uncharacterised motif that has some conserved regions. Conserved added due to identification of motif. Literature search identified paper giving further information on product function. Functional classification - Conserved hypothetical proteins; PMID:15228533; hypothetical protein 676192 905037 Cj0719c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344137.1 675560 R 192222 CDS YP_002344138.1 218562359 905038 complement(676227..676976) 1 NC_002163.1 Original (2000) note: Cj0720c, flaC, flagellin,len: 249 aa; 99.6% identical to TR:P96747 (EMBL:U85622) C. jejuni flaC, and similar to the N-terminus of e.g. FLAB_CAMJE flagellin B (CJ1338) (575 aa), fasta scores; opt: 236 z-score: 261.7 E(): 2.8e-07, 27.2% identity in 202 aa overlap. No Hp ortholog; Updated (2006) note: Pfam domain PF00669 Bacterial flagellin N-terminus identified within CDS. Further support given to product function. Characterised in Campylobacter and Escherichia coli with acceptable identity score. not added to product function. Literature search identified paper linking product function to adhesion and to play an important role in cell adhesion. Functional classification - Surface structures; PMID:15228533, PMID:16740937; flagellin 676976 flaC 905038 flaC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellin YP_002344138.1 676227 R 192222 CDS YP_002344139.1 218562360 905039 complement(677015..677485) 1 NC_002163.1 Original (2000) note: Cj0721c, probable integral membrane protein, len: 156 aa; 35.9% identity to HP0288; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0; integral membrane protein 677485 905039 Cj0721c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344139.1 677015 R 192222 CDS YP_002344140.1 218562361 905040 complement(677498..678313) 1 NC_002163.1 Original (2000) note: Cj0722c, probable DNA methylase, len: 271 aa; similar to members of the hemK family of methylases, e.g. HEMK_ECOLI HEMK protein (277 aa), fasta scores; opt: 262 z-score: 315.7 E(): 2.7e-10,26.1% identity in 276 aa overlap. 36.9% identity to HP0381. Contains PS00092 N-6 Adenine-specific DNA methylases signature; Updated (2006) note: Prosite domain PS50193 SAM_BIND, SAM (and some other nucleotide) binding motif identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification - DNA replication, restriction/modification, recombination and repair; DNA methylase 678313 905040 Cj0722c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA methylase YP_002344140.1 677498 R 192222 CDS YP_002344141.1 218562362 905041 complement(678310..679497) 1 NC_002163.1 Original (2000) note: Cj0723c, probable integral membrane zinc-metalloprotease, len: 395 aa; simimlar to yeast proteases e.g. ST24_YEAST CAAX prenyl protease 1 (453 aa), fasta scores; opt: 494 z-score: 565.5 E(): 3.4e-24, 31.6% identity in 430 aa overlap, and to prokaryotic htpX, e.g. HTPX_ECOLI heat shock protein HTPX (293 aa), fasta scores; opt: 183 z-score: 216.0 E(): 9.9e-05, 24.1% identity in 295 aa overlap. 38.6% identity to HP0382. Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature; Updated (2006) note: Pfam domain PF01435 Peptidase family M48 and Prosite domain PS00142 ZINC_PROTEASE,Peptidase M, neutral zinc metallopeptidases, zinc-binding site were identified within CDS. Also, Seven probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. No specific characterisation carried out yet. kept within product function. Functional classification - Proteins,peptides and glycopeptides; integral membrane zinc-metalloprotease 679497 905041 Cj0723c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane zinc-metalloprotease YP_002344141.1 678310 R 192222 CDS YP_002344142.1 218562363 905042 679624..679809 1 NC_002163.1 Original (2000) note: Cj0724, unknown, len: 61 aa; no Hp match. Functional classification - Unknown; hypothetical protein 679809 905042 Cj0724 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344142.1 679624 D 192222 CDS YP_002344143.1 218562364 905043 complement(679806..680348) 1 NC_002163.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 680348 mogA 905043 mogA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molybdenum cofactor biosynthesis protein MogA YP_002344143.1 679806 R 192222 CDS YP_002344144.1 218562365 905044 complement(680369..681352) 1 NC_002163.1 Original (2000) note: Cj0726c, corA, probable magnesium and cobalt transport protein, len: 327 aa; similar to e.g. CORA_ECOLI magnesium and cobalt transport protein CORA (316 aa), fasta scores; opt: 559 z-score: 616.2 E(): 5.1e-27, 31.3% identity in 329 aa overlap. 49.4% identity to HP1344; Updated (2006) note: Pfam domain PF01544 CorA-like Mg2+ transporter protein identified within CDS. Also, two probable transmembrane helices predicted for TMHMM2.0. Further support given to product function. Characterised within Escherichia coli and Salmonella typhimurium with marginal identity scores. not added to product function. Functional classification - Transport/binding proteins - Cations; PMID:1779764, PMID:9775386; magnesium and cobalt transport protein 681352 corA 905044 corA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 magnesium and cobalt transport protein YP_002344144.1 680369 R 192222 CDS YP_002344145.1 218562366 905045 681469..682515 1 NC_002163.1 Original (2000) note: Cj0727, probable periplasmic solute-binding protein, len: 348 aa; similar to e.g. SUBI_ECOLI sulfate-binding protein precursor (329 aa),fasta scores; opt: 220 z-score: 256.1 E(): 5.8e-07, 25.0% identity in 220 aa overlap. No Hp match. Contains N-terminal signal sequence; Updated (2006) note: Pfam domain PF01547 Bacterial extracellular solute-binding protein identified within CDS. Further support given to product function. Characterised within Escherichia coli, however, identity scores were unnacceptable. kept within product function. Functional classification - Transport/binding proteins - Other; periplasmic solute-binding protein 682515 905045 Cj0727 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic solute-binding protein YP_002344145.1 681469 D 192222 CDS YP_002344146.1 218562367 905046 682526..683851 1 NC_002163.1 Original (2000) note: Cj0728, probable periplasmic protein, len: 441 aa; no Hp match. Contains probable N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 683851 905046 Cj0728 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344146.1 682526 D 192222 CDS YP_002344147.1 218562368 905047 683848..684657 1 NC_002163.1 Original (2000) note: Cj0729, unknown, len: 269 aa; no Hp match; Updated (2006) note: Pfam domain PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet, so kept within product function. Functional classification - Purines,pyrimidines, nucleosides and nucleotides - Miscellaneous nucleoside/nucleotide reactions; type I phosphodiesterase/nucleotide pyrophosphatase 684657 905047 Cj0729 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 type I phosphodiesterase/nucleotide pyrophosphatase YP_002344147.1 683848 D 192222 CDS YP_002344148.1 218562369 905048 684654..685493 1 NC_002163.1 Original (2000) note: Cj0730, probable ABC transport system permease, len: 279 aa; similar to members of the binding protein-dependent permease family e.g. UGPA_ECOLI SN-glycerol-3-phosphate transport system permease (295 aa), fasta scores; opt: 273 z-score: 324.4 E(): 9.1e-11, 25.0% identity in 280 aa overlap. No Hp match. Contains Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Transport/binding proteins - Other; ABC transporter permease 685493 905048 Cj0730 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter permease YP_002344148.1 684654 D 192222 CDS YP_002344149.1 218562370 905049 685494..686273 1 NC_002163.1 Original (2000) note: Cj0731, probable ABC transport system permease, len: 259 aa; similar to members of the binding protein-dependent permease family e.g. POTC_ECOLI spermidine/putrescine transport system permease (264 aa), fasta scores; opt: 271 z-score: 337.3 E(): 1.7e-11, 24.1% identity in 241 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component; Updated (2006) note: Seven probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Transport/binding proteins - Other; ABC transporter permease 686273 905049 Cj0731 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter permease YP_002344149.1 685494 D 192222 CDS YP_002344150.1 218562371 905050 686277..687266 1 NC_002163.1 Original (2000) note: Cj0732, probable ABC transport system ATP-binding protein, len: 329 aa; similar to many e.g. POTA_ECOLI spermidine/putrescine transport ATP-binding protein (378 aa), fasta scores; opt: 802 z-score: 857.8 E(): 0, 43.2% identity in 292 aa overlap. No Hp otholog. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature and Pfam match to entry PF00005 ABC_tran; Updated (2006) note: Similar to more than one species with acceptable identity score. not added to product function. Functional classification -Transport/binding proteins - Other; ABC transporter ATP-binding protein 687266 905050 Cj0732 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter ATP-binding protein YP_002344150.1 686277 D 192222 CDS YP_002344151.1 218562372 905051 687263..687901 1 NC_002163.1 Original (2000) note: Cj0733, unknown, len: 212 aa; some similarity to hypotheical proteins from Actinomycetes e.g. TR:O69629 (EMBL:AL022121) Rv3661 (MTV025.009) (287 aa), fasta scores; opt: 264 z-score: 321.7 E(): 1.3e-10,28.4% identity in 215 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF00702 haloacid dehalogenase-like hydrolase identified within CDS. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Misc; HAD-superfamily hydrolase 687901 905051 Cj0733 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 HAD-superfamily hydrolase YP_002344151.1 687263 D 192222 CDS YP_002344152.1 218562373 905052 complement(687925..688680) 1 NC_002163.1 Original (2000) note: Cj0734c, hisJ, probable histidine-binding protein precursor, len: 251 aa; almost identical to HISJ_CAMJE histidine-binding protein precursor (256 aa) (88.7% identity in 256 aa overlap) and similar to many priplasmic amino-acid binding proteins e.g. HISJ_ECOLI histidine-binding periplasmic protein precursor (260 aa), fasta scores; opt: 343 z-score: 390.5 E(): 1.9e-14. 33.5% identity in 263 aa overlap. No Hp ortholog. Contains N-terminal signal sequence, PS00013 Prokaryotic membrane lipoprotein lipid attachment site,PS01039 Bacterial extracellular solute-binding proteins,family 3 signature, and Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3; Updated (2006) note: Characterised in Campylobacter jejuni. not added to product function. Functional classification - Transport/binding proteins - Amino acids and amines; PMID:9489038, PMID:15063560, PMID:9395059; histidine-binding protein precursor 688680 hisJ 905052 hisJ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 histidine-binding protein precursor YP_002344152.1 687925 R 192222 CDS YP_002344153.1 218562374 905053 689007..689726 1 NC_002163.1 Original (2000) note: Cj0735, probable periplasmic protein, len: 239 aa; no Hp match. Similar to N-terminus of Cj0967 (E(): 6.7e-15, 34.5% identity in 116 aa overlap); similarity continues in downstream CDS Cj0736. Contains probable N-terminal signal sequence; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 689726 905053 Cj0735 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344153.1 689007 D 192222 CDS YP_002344154.1 218562375 905054 689656..691584 1 NC_002163.1 Original (2000) note: Cj0736, unknown, len: 239 aa; no Hp match. Similar to C-terminus of Cj0967(E(): 0, 42.3% identity in 562 aa overlap); similarity continues from upstream CDS Cj0735; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 691584 905054 Cj0736 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344154.1 689656 D 192222 CDS YP_002344155.1 218562376 905055 691596..692672 1 NC_002163.1 Original (2000) note: Cj0737, probable periplasmic protein, len: 358 aa; simlar to the N-terminus of HXA3_HAEIN heme:hemopexin-binding protein precursor (hxuA) (917 aa), fasta scores; opt: 236 z-score: 251.5 E(): 1e-06, 32.8% identity in 180 aa overlap, and N-terminus of TR:Q48028 H. influenzae adhesin (1477 aa), fasta scores; opt: 292 z-score: 307.3 E(): 8.1e-10, 28.9% identity in 381 aa overlap. No Hp match. Similar in part to Cj0968 and Cj0969, probably representing a pseudogene copy of this CDS; Updated (2006) note: Pfam domain PF05860 haemagglutination activity domain identified within CDS. One probable transmembrane helix predicted by TMHMM2.0. Product modified to more specific family member due to motif match. kept as no specific characterisation. Functional classification - Misc; hemagglutination activity domain-containing protein 692672 905055 Cj0737 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hemagglutination activity domain-containing protein YP_002344155.1 691596 D 192222 CDS YP_002344156.1 218562377 905056 692726..692890 1 NC_002163.1 Original (2000) note: Cj0738, unknown, len: 54 aa; no Hp match. Functional classification - Unknown; hypothetical protein 692890 905056 Cj0738 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344156.1 692726 D 192222 CDS YP_002344157.1 218562378 905057 692878..693051 1 NC_002163.1 Original (2000) note: Cj0739, unknown, len: 57 aa; no Hp match. Functional classification - Unknown; hypothetical protein 693051 905057 Cj0739 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344157.1 692878 D 192222 CDS YP_002344158.1 218562379 905058 693048..693212 1 NC_002163.1 Original (2000) note: Cj0740, unknown, len: 54 aa; no Hp match. Functional classification - . Functional classification - Unknown; hypothetical protein 693212 905058 Cj0740 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344158.1 693048 D 192222 CDS YP_002344159.1 218562380 905059 693191..694117 1 NC_002163.1 Original (2000) note: Cj0741, unknown, len: 308 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 694117 905059 Cj0741 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344159.1 693191 D 192222 CDS YP_002344160.1 218562381 905062 702810..702917 1 NC_002163.1 Original (2000) note: Cj0747, unknown, len: 35 aa; no Hp match. Functional classification - Unknown; hypothetical protein 702917 905062 Cj0747 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344160.1 702810 D 192222 CDS YP_002344161.1 218562382 905063 703027..703119 1 NC_002163.1 Original (2000) note: Cj0748, unknown, len: 30 aa; no Hp match. Functional classification - Unknown; hypothetical protein 703119 905063 Cj0748 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344161.1 703027 D 192222 CDS YP_002344162.1 218562383 905065 complement(704442..705125) 1 NC_002163.1 Original (2000) note: Cj0753c, tonB3, probable tonB transport protein, len: 227 aa; almost identical to TONB_CAMCO C. coli tonB protein (232 aa); 96.6% identity in 232 aa overlap, and similar to e.g. TONB_ECOLI (239 aa,fasta scores; opt: 154 z-score: 170.4 E(): 0.034, 29.6% identity in 162 aa overlap. 34.6% identity to HP1341. Also similar to tonB2, Cj1630 (41.7% identity in 230 aa overlap); Updated (2006) note: Pfam domain PF03544 Gram-negative bacterial tonB protein identified within CDS. One probable transmembrane helix predicted by TMHMM2.0. Further support given to product function. Characterised within Campylobacter strains. not added to product function. Functional classification -Transport/binding proteins - Other; PMID:9190817, PMID:11395459; TonB transport protein 705125 tonB3 905065 tonB3 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 TonB transport protein YP_002344162.1 704442 R 192222 CDS YP_002344163.1 218562384 905066 705450..707540 1 NC_002163.1 Original (2000) note: Cj0755, cfrA, probable iron uptake protein (ferric receptor), len: 696 aa; almost identical to TR:O07651 (EMBL:U80812) C. coli ferric receptor CFRA (696 aa); 98.7% identity in 696 aa overlap. Also simimlar to e.g. TR:O87518 (EMBL:AF081285) E. coli exogenous ferric siderophore receptor R4 (669 aa), fasta scores; opt: 1127 z-score: 1247.0 E(): 0, 34.5% identity in 693 aa overlap. 23.4% identity to HP0686; Updated (2006) note: Pfam domains PF07715 TonB-dependent Receptor Plug Domain and PF00593 TonB dependent receptor identified within CDS. Further support given to product function. Characterisation work within Campylobacter jejuni (following on from Campylobacter coli), has led to product function being modified to more specfic family member. not added to product function. Functional classification - Transport/binding proteins - Cations; PMID:9190817, PMID:9765558, PMID:15231804,PMID:15632442; ferric enterobactin uptake receptor 707540 cfrA 905066 cfrA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ferric enterobactin uptake receptor YP_002344163.1 705450 D 192222 CDS YP_002344164.1 218562385 905067 707840..708634 1 NC_002163.1 Acts as a negative regulator of the grpE-dnaK-dnaJ and groELS class I heat shock operons by preventing heat-shock induction; heat-inducible transcription repressor 708634 hrcA 905067 hrcA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 heat-inducible transcription repressor YP_002344164.1 707840 D 192222 CDS YP_002344165.1 218562386 905068 708631..709161 1 NC_002163.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 709161 grpE 905068 grpE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 heat shock protein GrpE YP_002344165.1 708631 D 192222 CDS YP_002344166.1 218562387 905069 709183..711054 1 NC_002163.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 711054 dnaK 905069 dnaK Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molecular chaperone DnaK YP_002344166.1 709183 D 192222 CDS YP_002344167.1 218562388 905070 711314..712336 1 NC_002163.1 Original (2000) note: Cj0760, unknown, len: 340 aa; similar to hypothetical proteins e.g. YZ34_MYCTU Rv0906,(MTCY31.34) (372 aa), fasta scores; opt: 598 z-score: 724.2 E(): 4.8e-33, 29.9% identity in 335 aa overlap. Some similarity in C-terminus to ROMA_KLEPN outer membrane protein roma (fragment) (132 aa), fasta scores; opt: 335 z-score: 415.0 E(): 8.1e-16, 43.0% identity in 114 aa overlap. No Hp match; Updated (2006) note: Literature search identified paper giving clues to product function. Product function modified based on literature search. kept within product function. Functional classification - Conserved hypothetical proteins; PMID:15758238; hypothetical protein 712336 905070 Cj0760 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344167.1 711314 D 192222 CDS YP_002344168.1 218562389 905071 712406..712747 1 NC_002163.1 Original (2000) note: Cj0761, unknown, len: aa; similar to hypothetical proteins e.g. TR:O67079 (EMBL:AE000715) Aquifex aeolicus AQ_943 (107 aa), fasta scores; opt: 130 z-score: 186.5 E(): 0.0043, 28.6% identity in 84 aa overlap. 55.8% identity to HP0902; Updated (2006) note: Literature search identified paper giving clues to product function. Functional classification - Conserved hypothetical proteins; PMID:15758235; hypothetical protein 712747 905071 Cj0761 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344168.1 712406 D 192222 CDS YP_002344169.1 218562390 905072 complement(712797..713966) 1 NC_002163.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 713966 aspB 905072 aspB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aspartate aminotransferase YP_002344169.1 712797 R 192222 CDS YP_002344170.1 218562391 905073 complement(714138..714776) 1 NC_002163.1 Original (2000) note: Cj0763c, cysE, probable serine acetyltransferase, len: 212 aa; highly similar to many e.g. CYSE_BACSU serine acetyltransferase (EC 2.3.1.30) (217 aa), fasta scores; opt: 598 z-score: 700.2 E(): 1e-31, 46.6% identity in 204 aa overlap. 50.9% identity to HP1210. Contains PS00101 Hexapeptide-repeat containing-transferases signature and 2x Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats); Updated (2006) note: Characterised in Bacillus subtilis with acceptable identity score. not added to product function. Functional classification -Amino acid biosynthesis - Serine family; PMID:7510287; serine acetyltransferase 714776 cysE 905073 cysE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 serine acetyltransferase YP_002344170.1 714138 R 192222 CDS YP_002344171.1 218562392 905074 complement(714777..716612) 1 NC_002163.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 716612 speA 905074 speA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 arginine decarboxylase YP_002344171.1 714777 R 192222 CDS YP_002344172.1 218562393 905075 complement(716609..717835) 1 NC_002163.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 717835 hisS 905075 hisS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 histidyl-tRNA synthetase YP_002344172.1 716609 R 192222 CDS YP_002344173.1 218562394 905076 complement(717832..718410) 1 NC_002163.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 718410 tmk 905076 tmk Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 thymidylate kinase YP_002344173.1 717832 R 192222 CDS YP_002344174.1 218562395 905077 complement(718401..718877) 1 NC_002163.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 718877 coaD 905077 coaD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphopantetheine adenylyltransferase YP_002344174.1 718401 R 192222 CDS YP_002344175.1 218562396 905078 complement(718917..719480) 1 NC_002163.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 719480 905078 Cj0768c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_002344175.1 718917 R 192222 CDS YP_002344176.1 218562397 905079 complement(719477..720139) 1 NC_002163.1 required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 720139 flgA 905079 flgA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar basal body P-ring biosynthesis protein FlgA YP_002344176.1 719477 R 192222 CDS YP_002344177.1 218562398 905080 complement(720223..720999) 1 NC_002163.1 Original (2000) note: Cj0770c, probable periplasmic protein, len: 258 aa; similar to lipoproteins from other organisms e.g. PLPC_PASHA outer membrane lipoprotein 3 precursor (263 aa), fasta scores; opt: 569 z-score: 657.0 E(): 2.7e-29, 38.9% identity in 265 aa overlap, and TR:O69441 (EMBL:AJ005668) Legionella pneumophila 29 kda immunogenic protein (259 aa), fasta scores; opt: 584 z-score: 674.2 E(): 3e-30, 41.0% identity in 261 aa overlap. Also similar to Cj0772c (55.0% identity), Cj0771c (54.8% identity) and Cj1200 (44.9% identity). Single copy in Hp (HP1564); Updated (2006) note: Pfam domain PF03180 NLPA lipoprotein identified within CDS. NLPA lipoproteins are a family of bacterial lipoproteins that contain many antigenic members, which may be involved in bacterial virulence. The function is currently unknown. Product modified to more specific family member due to motif match. Some characterisation work in more than one species. Highly similar to Cj0771c and Cj0772c. kept within product function. Functional classification -Miscellaneous periplasmic proteins; PMID:12169620; NLPA family lipoprotein 720999 905080 Cj0770c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NLPA family lipoprotein YP_002344177.1 720223 R 192222 CDS YP_002344178.1 218562399 905081 complement(721009..721779) 1 NC_002163.1 Original (2000) note: Cj0771c, probable periplasmic protein, len: 258 aa; similar to lipoproteins from other organisms e.g. NLPA_ECOLI lipoprotein-28 precursor (272 aa), fasta scores; opt: 623 z-score: 705.2 E(): 5.6e-32,46.4% identity in 237 aa overlap, and TR:O69441 (EMBL:AJ005668) Legionella pneumophila 29 kda immunogenic protein (259 aa), fasta scores; opt: 661 z-score: 747.9 E(): 0, 44.2% identity in 258 aa overlap. Also similar to Cj0772c (52.5% identity), Cj0770c (54.8% identity) and Cj1200 (45.6% identity). Single copy in Hp (HP1564); Updated (2006) note: Pfam domain PF03180 NLPA lipoprotein identified within CDS. NLPA lipoproteins are a family of bacterial lipoproteins that contain many antigenic members, which may be involved in bacterial virulence. The function is currently unknown. Product modified to more specific family member due to motif match. Some characterisation in more than one species. Also similar to Cj0770c and Cj0772c. kept within product function. Functional classification -Miscellaneous periplasmic proteins; PMID:12169620; NLPA family lipoprotein 721779 905081 Cj0771c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NLPA family lipoprotein YP_002344178.1 721009 R 192222 CDS YP_002344179.1 218562400 905082 complement(721828..722601) 1 NC_002163.1 Original (2000) note: Cj0772c, probable periplasmic protein, len: 258 aa; similar to lipoproteins from other organisms e.g. PLPC_PASHA outer membrane lipoprotein 3 precursor (263 aa), fasta scores; opt: 642 z-score: 721.7 E(): 6.7e-33. 40.8% identity in 260 aa overlap, and TR:O69441 (EMBL:AJ005668) Legionella pneumophila 29 kda immunogenic protein (259 aa), fasta scores; opt: 638 z-score: 717.3 E(): 1.2e-32. 39.8% identity in 259 aa overlap. Also similar to Cj0770c (55.0% identity), Cj0771c (52.5% identity) and Cj1200 (57.5% identity). Single copy in Hp (HP1564; 47.7% identity in 243 aa overlap); Updated (2006) note: Pfam domain PF03180 NLPA lipoprotein identified within CDS. NLPA lipoproteins are a family of bacterial lipoproteins that contain many antigenic members, which may be involved in bacterial virulence. The function is currently unknown. Product modified to more specific family member due to motif match. Some characterisation in more than one species. Also similar to Cj0770c and Cj0771c. kept within product function. Functional classification -Miscellaneous periplasmic proteins; PMID:12169620; NLPA family lipoprotein 722601 905082 Cj0772c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NLPA family lipoprotein YP_002344179.1 721828 R 192222 CDS YP_002344180.1 218562401 905083 complement(722791..723702) 1 NC_002163.1 Original (2000) note: Cj0773c, probable binding-protein dependent transport system permease, len: 303 aa; similar to many e.g. PROW_BACSU glycine betaine/L-proline transport system permease (217 aa), fasta scores; opt: 212 z-score: 249.9 E(): 1.3e-06, 30.0% identity in 190 aa overlap. 43.9% identity in 205 aa overlap to HP1577. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component; Updated (2006) note: Seven probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. No specific characterisation with acceptable identity score carried out yet. added to product function. Functional classification -Transport/binding proteins - Other; PMID:12169620; binding-protein dependent transport system permease 723702 905083 Cj0773c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 binding-protein dependent transport system permease YP_002344180.1 722791 R 192222 CDS YP_002344181.1 218562402 905084 complement(723699..724709) 1 NC_002163.1 Original (2000) note: Cj0774c, probable ABC transport system ATP-binding protein, len: 336 aa; similar to many e.g. HISP_ECOLI histidine transport ATP-binding protein (257 aa), fasta scores; opt: 497 z-score: 566.5 E(): 2.9e-24, 38.5% identity in 262 aa overlap, and OCCP_AGRT6 octopine permease ATP-binding protein P (262 aa), fasta scores; opt: 511 z-score: 582.1 E(): 4e-25,36.9% identity in 260 aa overlap. 38.9% identity to HP1576. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Transport/binding proteins - Other; PMID:3313284; ABC transporter ATP-binding protein 724709 905084 Cj0774c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter ATP-binding protein YP_002344181.1 723699 R 192222 CDS YP_002344182.1 218562403 904417 complement(724714..727326) 1 NC_002163.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 727326 valS 904417 valS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 valyl-tRNA synthetase YP_002344182.1 724714 R 192222 CDS YP_002344183.1 218562404 905085 complement(727349..728371) 1 NC_002163.1 Original (2000) note: Cj0776c, probable periplasmic protein, len: 340 aa; no Hp match. Contains N-terminal signal sequence. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 728371 905085 Cj0776c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344183.1 727349 R 192222 CDS YP_002344184.1 218562405 905086 728500..730530 1 NC_002163.1 Original (2000) note: Cj0777, probable ATP-dependent DNA helicase, len: 676 aa; similar to many members of the uvrD family of helicases, e.g. PCRA_STAAU ATP-dependent helicase PCRA (675 aa), fasta scores; opt: 561 z-score: 634.4 E(): 4.9e-28, 29.0% identity in 694 aa overlap, and REP_ECOLI ATP-dependent DNA helicase REP (673 aa), fasta scores; opt: 423 z-score: 478.5 E(): 2.4e-19,27.3% identity in 682 aa overlap. 47.5% identity to HP0911. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry PF00580 UvrD-helicase,UvrD/REP helicase; Updated (2006) note: Characterisation work carried out within more than one species with marginal identity score. kept within product function. Functional classification - DNA replication,restriction/modification, recombination and repair; ATP-dependent DNA helicase 730530 905086 Cj0777 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP-dependent DNA helicase YP_002344184.1 728500 D 192222 CDS YP_002344185.1 218562406 905087 730569..731306 1 NC_002163.1 Original (2000) note: Cj0778, peb2, major antigenic peptide PEB2, len: 245 aa; 94.9% identical to TR:G234576,sequenced by direct peptide sequencing; see: J. Biol. Chem. 266:16363-16369 (1991). Also similar to TR:Q57410 (EMBL:U39068, U15606) Vibrio cholerae accessory colonization factor ACFC (253 aa), fasta scores; opt: 430 z-score: 499.2 E(): 1.7e-20, 33.9% identity in 248 aa overlap, and TR:P96759 (EMBL:U82533)E. coli O45 ANM protein (251 aa), fasta scores; opt: 417 z-score: 484.4 E(): 1.1e-19, 33.2% identity in 247 aa overlap. Contains N-terminal signal sequence; Updated (2006) note: Characterised in Campylobacter jejuni in 1991. not added to product function. Functional classification - Miscellaneous periplasmic proteins; PMID:1885571; major antigenic peptide PEB2 731306 peb2 905087 peb2 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 major antigenic peptide PEB2 YP_002344185.1 730569 D 192222 CDS YP_002344186.1 218562407 905088 731405..731932 1 NC_002163.1 Original (2000) note: Cj0779, tpx, probable thiol peroxidase, len: 175 aa; similar to e.g. TPX_ECOLI thiol peroxidase (EC 1.11.1.-) (167 aa), fasta scores; opt: 407 z-score: 489.0 E(): 6.1e-20, 44.2% identity in 154 aa overlap, and TAGD_VIBCH TAGD protein (164 aa), fasta scores; opt: 381 z-score: 458.8 E(): 3e-18, 39.9% identity in 158 aa overlap. 42.2% identity to HP0390. Contains PS01265 Tpx family signature, and Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. not added to product function. Literature search also revealed additional papers with experiments in Campylobacter. Paper identified linking protein to glycoprotein (PMID:12186869). Functional classification -Detoxification; PMID:15632442, PMID:12069882, PMID:12186869; thiol peroxidase 731932 tpx 905088 tpx Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 thiol peroxidase YP_002344186.1 731405 D 192222 CDS YP_002344187.1 218562408 905089 732179..734953 1 NC_002163.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 734953 napA 905089 napA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 nitrate reductase catalytic subunit YP_002344187.1 732179 D 192222 CDS YP_002344188.1 218562409 904514 734971..735711 1 NC_002163.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 735711 napG 904514 napG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 quinol dehydrogenase periplasmic component YP_002344188.1 734971 D 192222 CDS YP_002344189.1 218562410 904348 735708..736490 1 NC_002163.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 736490 napH 904348 napH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 quinol dehydrogenase membrane component YP_002344189.1 735708 D 192222 CDS YP_002344190.1 218562411 904951 736487..737011 1 NC_002163.1 Original (2000) note: Cj0783, napB, probable cytochrome C-type protein (periplasmic nitrate reductase small subunit), len: 174 aa; similar to e.g. NAPB_ECOLI cytochrome C-type protein NAPB precursor (149 aa), fasta scores; opt: 269 z-score: 327.2 E(): 6.3e-11,38.1% identity in 97 aa overlap. No Hp match. Contains 2x PS00190 Cytochrome c family heme-binding site signature,N-terminla signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Pfam domain PF03892 Nitrate reductase cytochrome c-type subunit identified within CDS. Further support given to product function. Characterised in Escherichia coli and Wolinella succinogenes with acceptable identity score, thus not needed. Literature search identified paper given further information on product function. Functional classification - Respiration - Electron transport; PMID:12107136, PMID:16436444, PMID:12823811; periplasmic nitrate reductase small subunit 737011 napB 904951 napB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic nitrate reductase small subunit YP_002344190.1 736487 D 192222 CDS YP_002344191.1 218562412 905090 737016..737930 1 NC_002163.1 Original (2000) note: Cj0784, probable periplasmic protein, len: 304 aa; no Hp match. Contains N-terminal signal sequence; Updated (2006) note: Some characterisation work within Wolinella succinogenes with acceptable identity score. Functional classification - Miscellaneous periplasmic proteins; PMID:12823811; periplasmic protein 737930 napL 905090 napL Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344191.1 737016 D 192222 CDS YP_002344192.1 218562413 905091 737923..738261 1 NC_002163.1 Original (2000) note: Cj0785, napD, possible napD protein, len: 112 aa; very weak similarity to e.g. NAPD_PARDT NAPD protein (112 aa), fasta scores; opt: 102 z-score: 146.1 E(): 0.77, 22.9% identity in 83 aa overlap,and NAPD_ECOLI NAPD protein (87 aa), blastp scores; E = 4.7e-05, 23% identity in 72 bp overlap. No Hp match; Updated (2006) note: Pfam domain PF03927 NapD protein identified within CDS. Further support given to product function. Some work carried out within Wolinella succinogenes. kept within product function. Literature search identified papers giving further information on protein product. Functional classification - Energy metabolism - Electron transport; PMID:12107136, PMID:12823811; NapD protein 738261 napD 905091 napD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NapD protein YP_002344192.1 737923 D 192222 CDS YP_002344193.1 218562414 905092 738274..738447 1 NC_002163.1 Original (2000) note: Cj0786, small hydrophobic protein, len: 57 aa; no Hp match; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Unknown; hypothetical protein 738447 905092 Cj0786 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344193.1 738274 D 192222 CDS YP_002344194.1 218562415 905224 738526..738774 1 NC_002163.1 Original (2000) note: Cj0787, unknown, len: 82 aa; 38.1% identity to HP0168; Updated (2006) note: Prosite domain PS50293 TPR_REGION, Tetratricopeptide region identified within CDS. Functional classification - Conserved hypothetical proteins; hypothetical protein 738774 905224 Cj0787 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344194.1 738526 D 192222 CDS YP_002344195.1 218562416 905093 738771..739262 1 NC_002163.1 Original (2000) note: Cj0788, unknown, len: 163 aa; 30.8% identity to HP0167. Functional classification -Conserved hypothetical proteins; hypothetical protein 739262 905093 Cj0788 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344195.1 738771 D 192222 CDS YP_002344196.1 218562417 905094 739231..740349 1 NC_002163.1 Original (2000) note: Cj0789, probable RNA nucleotidyltransferase, len: 372 aa;p similar in C-terminus to C-terminus of e.g. CCA_ECOLI tRNA nucleotidyltransferase (412 aa), fasta scores; opt: 343 z-score: 412.9 E(): 1.1e-15, 35.4% identity in 212 aa overlap, and PAPS_BACSU poly(A) polymerase (397 aa), fasta scores; opt: 338 z-score: 407.2 E(): 2.2e-15, 29.3% identity in 294 aa overlap. 24.9% identity to HP0640. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Pfam domain PF01743 Poly A polymerase family protein identified within CDS. Further support to product function. Product function modified based on updated characterisation naming within Escherichia coli. Functional classification - RNA synthesis, RNA modification and DNA transcription; PMID:3009457, PMID:3516995, PMID:15210699; multifunctional Cca protein 740349 cca 905094 cca Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 multifunctional Cca protein YP_002344196.1 739231 D 192222 CDS YP_002344197.1 218562418 905095 740346..741170 1 NC_002163.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 741170 purU 905095 purU Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 formyltetrahydrofolate deformylase YP_002344197.1 740346 D 192222 CDS YP_002344198.1 218562419 905097 complement(741167..742441) 1 NC_002163.1 Original (2000) note: Cj0791c, probable aminotransferase, len: 424 aa; similar to many members of the nifS family e.g. TR:O32164 (EMBL:Z99120) B. subtilis YURW protein (406 aa), fasta scores; opt: 289 z-score: 340.6 E(): 1.1e-11, 23.9% identity in 431 aa overlap. 45.4% identity to HP0405. Contains PS00455 AMP-binding domain signature and PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification -Misc; aminotransferase 742441 905097 Cj0791c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aminotransferase YP_002344198.1 741167 R 192222 CDS YP_002344199.1 218562420 905098 742477..743355 1 NC_002163.1 Original (2000) note: Cj0792, unknown, len: 292 aa; some similarity to hypothetical proteins e.g. YZ04_METJA hypothetical protein MJECL04 (439 aa), fasta scores; opt: 175 z-score: 208.0 E(): 0.00027, 26.5% identity in 309 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03008 Archaea bacterial proteins of unknown function identified within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 743355 905098 Cj0792 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344199.1 742477 D 192222 CDS YP_002344200.1 218562421 905099 743359..744378 1 NC_002163.1 Original (2000) note: Cj0793, probable signal transduction histidine kinase, len: 339 aa; similar to e.g. the C-terminus of ATOS_ECOLI sensor protein ATOS (608 aa), fasta scores; opt: 357 z-score: 408.3 E(): 1.9e-15,33.3% identity in 222 aa overlap. 42.4% identity to HP0244. Contains Pfam match to entry PF00512 signal,Signal carboxyl-terminal domain; Updated (2006) note: Characterised within Campylobacter jejuni and Helicobacter pylori. not added to product function. Literature search identified papers linking Cj0793 and Cj1024 to a two-component signal transduction system (FlgS/FlgR) that regulates the fla regulon in Campylobacter jejuni (similar to that found in Helicobacter pylori). Functional classification - Signal transduction; PMID:14960570, PMID:15231786, PMID:14617189; signal transduction histidine kinase 744378 flgS 905099 flgS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 signal transduction histidine kinase YP_002344200.1 743359 D 192222 CDS YP_002344201.1 218562422 905100 744495..745775 1 NC_002163.1 Original (2000) note: Cj0794, unknown, len: 426 aa; no Hp match. Has consecutive regions of near-identity to Cj0814 (73.9% identity in 253 aa overlap), Cj0815 (61.6% identity in 86 aa overlap) and Cj0816 (63.6% identity in 44 aa overlap), which may represent a pseudogene copy of this CDS; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 745775 905100 Cj0794 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344201.1 744495 D 192222 CDS YP_002344202.1 218562423 905101 complement(745833..747260) 1 NC_002163.1 Original (2000) note: Cj0795c, murF, possible UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate -- ligase, len: 475 aa; some similarity to e.g. MURF_BACSU UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate -- ligase (EC 6.3.2.15) (457 aa), fasta scores; opt: 235 z-score: 258.7 E(): 4.1e-07, 26.7% identity in 348 aa overlap. 41.5% identity to HP0740; Updated (2006) note: Pfam domains PF01225 Mur ligase family, catalytic domain and PF02875 Mur ligase family, glutamate ligase domain were identified within CDS. Also, three probable transmembrane helices predicted by TMHMM2.0 within CDS. Further support given to product function. Characterisation work carried out within Escherichia coli and Bacillus subtilis with mariginal identity scores. not added to product function. Product function and EC number updated. Functional classification - Murein sacculus and peptidoglycan; PMID:11090285, PMID:2668880, PMID:9305945; UDP-N-acetylmuramoyl-tripeptide D-alanyl-D-alanine ligase 747260 murF 905101 murF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-N-acetylmuramoyl-tripeptide D-alanyl-D-alanine ligase YP_002344202.1 745833 R 192222 CDS YP_002344203.1 218562424 905199 complement(747261..747980) 1 NC_002163.1 Original (2000) note: Cj0796c, unknown, len: 239 aa; 46.3% identity to HP0739 (annotated as 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase); Updated (2006) note: Pfam domain PF00561 alpha/beta hydrolase fold and Prosite domain PS50187 Esterase/lipase/thioesterase active site serine identified within CDS. The latter are found in alpha/beta fold hydrolase. Product function modified due to motif match. No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification - Misc; hydrolase 747980 905199 Cj0796c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hydrolase YP_002344203.1 747261 R 192222 CDS YP_002344204.1 218562425 905230 complement(747982..748197) 1 NC_002163.1 Original (2000) note: Cj0797c, unknown, len: 71 aa; weak similarity to TR:O68849 (EMBL:AF055586) ORF10 in Vibrio cholerae integron InVch (80 aa), fasta scores; opt: 95 z-score: 151.4 E(): 0.39, 39.2% identity in 51 aa overlap. No Hp match. Functional classification -Conserved hypothetical proteins; hypothetical protein 748197 905230 Cj0797c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344204.1 747982 R 192222 CDS YP_002344205.1 218562426 905128 complement(748257..749297) 1 NC_002163.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 749297 ddl 905128 ddl Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 D-alanyl-alanine synthetase A YP_002344205.1 748257 R 192222 CDS YP_002344206.1 218562427 905102 complement(749307..749858) 1 NC_002163.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 749858 ruvA 905102 ruvA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Holliday junction DNA helicase RuvA YP_002344206.1 749307 R 192222 CDS YP_002344207.1 218562428 905103 complement(749834..751693) 1 NC_002163.1 Original (2000) note: Cj0800c, unknown, len: 619 aa; 24.7% identity to HP0884. Also similar to Cj0044c (28.6% identity in 622 aa overlap); Updated (2006) note: Prosite domain PS00389 ATPase,F1 complex, OSCP/delta subunit signature identified within CDS. Product modified to more specific family member due to motif match. Not fully characterised so kept within product function. Functional classification - Misc; ATPase 751693 905103 Cj0800c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATPase YP_002344207.1 749834 R 192222 CDS YP_002344208.1 218562429 905104 751797..753248 1 NC_002163.1 Original (2000) note: Cj0801, probable integral membrane protein, len: 483 aa; similar to MVIN_SALTY virulence factor MVIN (524 aa), fasta scores; opt: 725 z-score: 828.0 E(): 0, 32.4% identity in 463 aa overlap,and to homologs from other organisms. 45.8% identity to HP0885; Updated (2006) note: Eleven probable transmembrane helices predicted by TMHMM2.0. Also, Pfam domain PF03023 MviN-like protein identified within CDS. Still not functionally characterised. Homolog designation kept within product function. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 753248 905104 Cj0801 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344208.1 751797 D 192222 CDS YP_002344209.1 218562430 905105 753248..754636 1 NC_002163.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 754636 cysS 905105 cysS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cysteinyl-tRNA synthetase YP_002344209.1 753248 D 192222 CDS YP_002344210.1 218562431 905106 754629..756371 1 NC_002163.1 Original (2000) note: Cj0803, msbA, probable lipid export ABC transport protein, len: 580 aa; similar to lipid export protein MSBA_ECOLI probable transport ATP-binding protein MSBA (582 aa), fasta scores; opt: 1032 z-score: 1135.9 E(): 0, 29.6% identity in 575 aa overlap,and to other members of the mutidrug-resistance family of ABC transporters. 42.7% identity to HP1082. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region, and Pfam match to entry PF00005 ABC_tran, ABC transporters; Updated (2006) note: Characterised in Escherichia coli with marginal identity score. Appropriate motifs present. not needed to product function. Functional classification - Transport/binding proteins -Other; PMID:16159769, PMID:12119303; lipid export ABC transport protein 756371 msbA 905106 msbA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipid export ABC transport protein YP_002344210.1 754629 D 192222 CDS YP_002344211.1 218562432 905107 756403..757461 1 NC_002163.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 757461 pyrD 905107 pyrD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dihydroorotate dehydrogenase 2 YP_002344211.1 756403 D 192222 CDS YP_002344212.1 218562433 905108 757458..758708 1 NC_002163.1 Original (2000) note: Cj0805, probable zinc protease, len: 416 aa; similar to many members of the insulinase family e.g. Y4WA_RHISN hypothetical zinc protease Y4WA (512 aa), fasta scores; opt: 664 z-score: 739.8 E(): 0, 31.8% identity in 415 aa overlap. 57.2% identity to HP1012. Contains PS00143 Insulinase family,zinc-binding region signature, and Pfam match to entry PF00675 Insulinase, Insulinase (proteinase M16); Updated (2006) note: Pfam domain PF05193 Peptidase M16 inactive domain identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification -Proteins, peptides and glycopeptides; zinc protease 758708 905108 Cj0805 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 zinc protease YP_002344212.1 757458 D 192222 CDS YP_002344213.1 218562434 905109 758701..759597 1 NC_002163.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 759597 dapA 905109 dapA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dihydrodipicolinate synthase YP_002344213.1 758701 D 192222 CDS YP_002344214.1 218562435 905110 759597..760376 1 NC_002163.1 Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 760376 905110 Cj0807 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 7-alpha-hydroxysteroid dehydrogenase YP_002344214.1 759597 D 192222 CDS YP_002344215.1 218562436 905112 complement(760417..760722) 1 NC_002163.1 Original (2000) note: Cj0808c, small hydrophobic protein, len: 101 aa; no Hp match; Updated (2006) note: Three probable transmembrane helices predicted by TMHMM2.0. Functional classification -Unknown; hypothetical protein 760722 905112 Cj0808c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344215.1 760417 R 192222 CDS YP_002344216.1 218562437 905113 complement(760734..761330) 1 NC_002163.1 Original (2000) note: Cj0809c, possible hydrolase,len: 198 aa; similar to many hypothetical proteins belonging to the glyoxalase II family e.g. YQGX_BACSU (211 aa), fasta scores; opt: 289 z-score: 365.7 E(): 4.5e-13,32.8% identity in 204 aa overlap. 44.3% identity to HP0813. Contains Pfam match to entry PF00753 lactamase_B,Metallo-beta-lactamase superfamily; Updated (2006) note: No specific characterisation with acceptable identity scores carried out yet. kept within product function. Functional classification -Misc; hydrolase 761330 905113 Cj0809c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hydrolase YP_002344216.1 760734 R 192222 CDS YP_002344217.1 218562438 906011 761404..762144 1 NC_002163.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 762144 nadE 906011 nadE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NAD synthetase YP_002344217.1 761404 D 192222 CDS YP_002344218.1 218562439 905114 762148..763074 1 NC_002163.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 763074 lpxK 905114 lpxK Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tetraacyldisaccharide 4'-kinase YP_002344218.1 762148 D 192222 CDS YP_002344219.1 218562440 905115 763071..764483 1 NC_002163.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 764483 thrC 905115 thrC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 threonine synthase YP_002344219.1 763071 D 192222 CDS YP_002344220.1 218562441 905116 764480..765199 1 NC_002163.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 765199 kdsB 905116 kdsB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 3-deoxy-manno-octulosonate cytidylyltransferase YP_002344220.1 764480 D 192222 CDS YP_002344221.1 218562442 905117 765304..766059 1 NC_002163.1 Original (2000) note: Cj0814, unknown, len: 251 aa; no Hp match. Almost identical to the N-teminus of Cj0794; similarity continues in Cj0815 and Cj0816: may represent a pseudogene fragment; Updated (2006) note: Similar to hypothetical proteins from other bacteria; hypothetical protein 766059 905117 Cj0814 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344221.1 765304 D 192222 CDS YP_002344222.1 218562443 905118 766075..766419 1 NC_002163.1 Original (2000) note: Cj0815, unknown, len: 114 aa; no Hp match. Almost identical to the centre of Cj0794; similarity continues from Cj0814 and into Cj0816: may represent a pseudogene fragment. Functional classification - Unknown; hypothetical protein 766419 905118 Cj0815 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344222.1 766075 D 192222 CDS YP_002344223.1 218562444 905119 766427..766597 1 NC_002163.1 Original (2000) note: Cj0816, unknown, len: 56 aa; no Hp match. Almost identical to the C-terminus of Cj0794; similarity continues from Cj0814 and Cj0815: may represent a pseudogene fragment. Functional classification -Unknown; hypothetical protein 766597 905119 Cj0816 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344223.1 766427 D 192222 CDS YP_002344224.1 218562445 905120 766692..767462 1 NC_002163.1 Original (2000) note: Cj0817, glnH, probable glutamine-binding periplasmic protein, len: 256 aa; similar to e.g. GLNH_ECOLI glutamine-binding periplasmic protein precursor (248 aa), fasta scores; opt: 382 z-score: 441.9 E(): 2.6e-17, 32.5% identity in 243 aa overlap. 29.0% identity to HP0940. Contains Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3; Updated (2006) note: Characterised with marginal identity scores in more than one bacteria. Prosite domain PS50121, Solute binding protein/glutamate receptor domain identified within CDS. Further support given to product function. added to product function. Functional classification - Transport/binding proteins - Amino acids and amines; PMID:3027504, PMID:9571045, PMID:9142743; glutamine binding periplasmic protein 767462 glnH 905120 glnH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glutamine binding periplasmic protein YP_002344224.1 766692 D 192222 CDS YP_002344225.1 218562446 905121 767555..767782 1 NC_002163.1 Original (2000) note: Cj0818, probable lipoprotein,len: 75 aa; no Hp match. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification - Membranes, lipoproteins and porins; lipoprotein 767782 905121 Cj0818 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002344225.1 767555 D 192222 CDS YP_002344226.1 218562447 905123 767808..768032 1 NC_002163.1 Original (2000) note: Cj0819, small hydrophobic protein, len 74 aa; no Hp match; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Functional classification -Unknown; hypothetical protein 768032 905123 Cj0819 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344226.1 767808 D 192222 CDS YP_002344227.1 218562448 905124 complement(768029..768763) 1 NC_002163.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 768763 fliP 905124 fliP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar biosynthesis protein FliP YP_002344227.1 768029 R 192222 CDS YP_002344228.1 218562449 905125 768906..770195 1 NC_002163.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 770195 glmU 905125 glmU Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_002344228.1 768906 D 192222 CDS YP_002344229.1 218562450 905213 770192..771346 1 NC_002163.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 771346 dfp 905213 dfp Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_002344229.1 770192 D 192222 CDS YP_002344230.1 218562451 905126 771343..771960 1 NC_002163.1 Original (2000) note: Cj0823, unknown, len: 205 aa; 24.3% identity to HP0842; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Unknown; hypothetical protein 771960 905126 Cj0823 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344230.1 771343 D 192222 CDS YP_002344231.1 218562452 905127 771964..772632 1 NC_002163.1 Original (2000) note: Cj0824, uppS, probable UDP diphosphate synthase, len: 222 aa; similar to TR:O82827 (EMBL:AB004319) Micrococcus luteus UDP diphosphate synthase (249 aa), fasta scores; opt: 365 z-score: 445.7 E(): 1.6e-17, 35.2% identity in 227 aa overlap, and to other members of the UPF0015 family e.g. YAES_ECOLI (252 aa), fasta scores; opt: 371 z-score: 452.7 E(): 6.4e-18, 37.2% identity in 226 aa overlap. 42.6% identity to HP1221. Contains Pfam match to entry PF01255 UPF0015; Updated (2006) note: Previous Pfam domain has now been given a classification as PF01255 UDP diphosphate synthase. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. UPPS (UDP pyrophosphate synthase) catalyses consecutive condensation reactions of FPP (farnesyl pyrophosphate) with eight isopentenyl pyrophosphates to generate C55 UPP, which serves as a lipid carrier for bacterial peptidoglycan biosynthesis. removed from product function. Functional classification - Synthesis and modification of macromolecules - Phospholipids; PMID:9882662, PMID:12756244, PMID:15447632; UDP diphosphate synthase 772632 uppS 905127 uppS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP diphosphate synthase YP_002344231.1 771964 D 192222 CDS YP_002344232.1 218562453 905130 772629..773405 1 NC_002163.1 Original (2000) note: Cj0825, possible processing peptidase, len: 258 aa; similar to e.g. LEP3_VIBCH type 4 prepilin-like protein specific leader peptidase (253 aa),fasta scores; opt: 261 z-score: 323.9 E(): 9.7e-11, 28.5% identity in 260 aa overlap. No Hp match. Contains several probable membrane spanning domains; Updated (2006) note: Pfam domains PF06750 Bacterial Peptidase A24 N-terminal domain and PF01478 Type IV leader peptidase family were identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet. kept within product function. Literature search identified literature giving further clues to product function. Functional classification - Protein translation and modification; PMID:12949093, PMID:2553669; processing peptidase 773405 905130 Cj0825 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 processing peptidase YP_002344232.1 772629 D 192222 CDS YP_002344233.1 218562454 905219 773405..774430 1 NC_002163.1 Original (2000) note: Cj0826, probable integral membrane protein, len: 341 aa; similar to hypothetical membrane proteins e.g. YJGP_HAEIN (372 aa), fasta scores; opt: 203 z-score: 236.9 E(): 6.8e-06, 21.7% identity in 314 aa overlap. 32.3% identity to HP0362; Updated (2006) note: Pfam domain PF03739 Predicted permease YjgP/YjgQ family identified within CDS. Members of this family are predicted integral membrane proteins of unknown function. Also, six probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 774430 905219 Cj0826 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344233.1 773405 D 192222 CDS YP_002344234.1 218562455 904389 774427..775152 1 NC_002163.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 775152 truA 904389 truA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tRNA pseudouridine synthase A YP_002344234.1 774427 D 192222 CDS YP_002344235.1 218562456 904335 complement(775149..776360) 1 NC_002163.1 catalyzes the formation of 2-oxobutanoate from L-threonine; threonine dehydratase 776360 ilvA 904335 ilvA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 threonine dehydratase YP_002344235.1 775149 R 192222 CDS YP_002344236.1 218562457 905131 complement(776360..776773) 1 NC_002163.1 Original (2000) note: Cj0829c, unknown, len: 137 aa; similar to hypothetical proteins e.g. TR:P75874 (EMBL:AE000198) E. coli b0965 (164 aa), fasta scores; opt: 240 z-score: 312.1 E(): 4.4e-10, 30.3% identity in 132 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02629 CoA binding domain identified within CDS. Product modified to new family member based on motif match. No specific characterisation has been carried out yet. kept within product function. Functional classification - Misc; CoA binding domain containing protein 776773 905131 Cj0829c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CoA binding domain containing protein YP_002344236.1 776360 R 192222 CDS YP_002344237.1 218562458 904930 776892..777308 1 NC_002163.1 Original (2000) note: Cj0830, probable integral membrane protein, len: 138 aa; 42.7% identity to HP1502; Updated (2006) note: Pfam domain PF04323 Protein of unknown function (DUF474) identified within CDS. Also,four probable transmembrane helices predicted by TMHMM2.0. Literature search identified paper giving potential clues to product function. Functional classification -Membranes, lipoproteins and porins; PMID:16045618; integral membrane protein 777308 904930 Cj0830 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344237.1 776892 D 192222 CDS YP_002344238.1 218562459 905134 complement(777295..778368) 1 NC_002163.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 778368 trmA 905134 trmA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tRNA (uracil-5-)-methyltransferase YP_002344238.1 777295 R 192222 CDS YP_002344239.1 218562460 904915 complement(778365..780098) 1 NC_002163.1 Original (2000) note: Cj0832c, probable integral membrane protein, len: 577 aa; similar to hypothetical proteins e.g. TR:O59530 (EMBL:AP000007) Pyrococcus horikoshii PH1889 (533 aa), fasta scores; opt: 628 z-score: 744.4 E(): 0, 39.2% identity in 558 aa overlap. 26.9% identity to HP0946; Updated (2006) note: Pfam domain PF03553 Na+/H+ antiporter family identified within CDS. Also, thirteen probable transmembrane helices predicted by TMHMM2. Product modified to more specific family member based on motif match. No specific characterisation carried out yet,so kept within product function. Functional classification - Transport/binding proteins - Cations; Na+/H+ antiporter family protein 780098 904915 Cj0832c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Na+/H+ antiporter family protein YP_002344239.1 778365 R 192222 CDS YP_002344240.1 218562461 905132 complement(780095..780844) 1 NC_002163.1 Original (2000) note: Cj0833c, probable oxidoreductase, len: 249 aa; simlar to e.g. YDFG_ECOLI probable oxidoreductase (248 aa), fasta scores; opt: 796 z-score: 943.5 E(): 0, 48.8% identity in 244 aa overlap. 47.3% identity to HP0357. Contains PS00061 Short-chain dehydrogenases/reductases family signature, and Pfam match to entry PF00106 adh_short, Alcohol/other dehydrogenases,short chain type; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. kept within product function. Functional classification -Misc; PMID:12535615; oxidoreductase 780844 905132 Cj0833c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 oxidoreductase YP_002344240.1 780095 R 192222 CDS YP_002344241.1 218562462 905133 complement(780841..782079) 1 NC_002163.1 Original (2000) note: Cj0834c, possible periplasmic protein, len: 412 aa; similar in C-terminus to ankyrin repeat-containing proteins e.g. ANKH_CHRVI ankyrin homolog precursor (323 aa), fasta scores; opt: 194 z-score: 229.9 E(): 1.7e-05, 28.9% identity in 194 aa overlap. No Hp match. Some similarity to ankyrin repeats in Cj1386 (29.3% identity in 99 aa overlap). Contains 2x Pfam match to entry PF00023 ank, Ank repeat, and possible N-terminal signal sequence; Updated (2006) note: No specific characterisation with acceptable identity scores carried out yet. kept within product function. Functional classification -Miscellaneous periplasmic proteins; ankyrin repeat-containing periplasmic protein 782079 905133 Cj0834c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ankyrin repeat-containing periplasmic protein YP_002344241.1 780841 R 192222 CDS YP_002344242.1 218562463 905137 complement(782129..784675) 1 NC_002163.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 784675 acnB 905137 acnB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase YP_002344242.1 782129 R 192222 CDS YP_002344243.1 218562464 904456 784730..785182 1 NC_002163.1 Original (2000) note: Cj0836, ogt, probable methylated-DNA--protein-cysteine methyltransferase, len: 150 aa; similar to many e.g. OGT_ECOLI methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (171 aa), fasta scores; opt: 274 z-score: 355.6 E(): 1.6e-12, 43.7% identity in 103 aa overlap, and DAT1_BACSU methylated-DNA--protein-cysteine methyltransferase (165 aa), fasta scores; opt: 358 z-score: 460.7 E(): 2.3e-18, 44.5% identity in 137 aa overlap. 45.3% identity to HP0676. Contains PS00374 Methylated-DNA--protein-cysteine methyltransferase active site and Pfam match to entry PF01035 Methyltrans,6-O-methylguanine DNA methyltransferase; Updated (2006) note: Characterised in Escherichia coli and Bacillus subtilis with acceptable identity score. not added to product function. Functional classification - DNA replication,restriction/modification, recombination and repair; PMID:2506524; methylated-DNA--protein-cysteine methyltransferase 785182 ogt 904456 ogt Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methylated-DNA--protein-cysteine methyltransferase YP_002344243.1 784730 D 192222 CDS YP_002344244.1 218562465 905005 complement(785174..786115) 1 NC_002163.1 Original (2000) note: Cj0837c, unknown, len: 313 aa; no Hp match. Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1, and PS00030 Eukaryotic RNA-binding region RNP-1 signature. Functional classification - Unknown; hypothetical protein 786115 905005 Cj0837c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344244.1 785174 R 192222 CDS YP_002344245.1 218562466 905186 complement(786119..788005) 1 NC_002163.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 788005 metG 905186 metG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methionyl-tRNA synthetase YP_002344245.1 786119 R 192222 CDS YP_002344246.1 218562467 905138 complement(788015..788212) 1 NC_002163.1 Original (2000) note: Cj0839c, unknown, len: 65 aa; 43.1% identity to HP1384. Functional classification -Conserved hypothetical proteins; hypothetical protein 788212 905138 Cj0839c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344246.1 788015 R 192222 CDS YP_002344247.1 218562468 905148 complement(788205..789047) 1 NC_002163.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 789047 fbp 905148 fbp Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 fructose-1,6-bisphosphatase YP_002344247.1 788205 R 192222 CDS YP_002344248.1 218562469 904424 complement(789049..789540) 1 NC_002163.1 Original (2000) note: Cj0841c, probable ATP/GTP binding protein, len: 163 aa; some similarity to e.g. MOBB_ECOLI molybdopterin-guanine dinucleotide biosynthesis protein B (174 aa), fasta scores; opt: 148 z-score: 194.1 E(): 0.0016, 25.6% identity in 168 aa overlap. No Hp match. Contains S00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Pfam domain PF03205 Molybdopterin guanine dinucleotide synthesis protein B identified within CDS. Further support for product function. Characterisation papers form Escherichia coli have been attached. This information and identification of appropriate motifs has led to product function being modified to a more specific family member. kept within product function. Functional classification -Biosynthesis of cofactors, prosthetic groups and carriers - Molybdopterin; PMID:12372836, PMID:9219527; molybdopterin-guanine dinucleotide biosynthesis protein 789540 mobB 904424 mobB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molybdopterin-guanine dinucleotide biosynthesis protein YP_002344248.1 789049 R 192222 CDS YP_002344249.1 218562470 905139 789636..790121 1 NC_002163.1 Original (2000) note: Cj0842, probable lipoprotein,len: 161 aa; no Hp match. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification - Membranes, lipoproteins and porins; lipoprotein 790121 905139 Cj0842 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002344249.1 789636 D 192222 CDS YP_002344250.1 218562471 905140 complement(790018..791643) 1 NC_002163.1 Original (2000) note: Cj0843c, probable secreted transglycosylase, len: 541 aa; some simialarity in C-terminus to SLT_ECOLI soluble lytic murein transglycosylase precursor (645 aa), fasta scores; opt: 257 z-score: 285.7 E(): 1.3e-08, 29.3% identity in 208 aa overlap. 31.4% identity to HP0645. Contains PS00922 Prokaryotic transglycosylases signature and N-terminal signal sequence; Updated (2006) note: Pfam domain PF01464 Transglycosylase SLT domain identified within CDS. Further support given to product function. kept within product function as identity scores were marginal and alignment was only partial. Paper identified linking product function to glycosylation. Functional classification - Degradation of macromolecules - Proteins,peptides and glycopeptides; PMID:12186869; secreted transglycosylase 791643 905140 Cj0843c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 secreted transglycosylase YP_002344250.1 790018 R 192222 CDS YP_002344251.1 218562472 905141 complement(791640..791921) 1 NC_002163.1 Original (2000) note: Cj0844c, possible integral membrane protein, len: 93 aa; 38.4% identity to HP0644; Updated (2006) note: Pfam domain PF02325 YGGT family identified within CDS. This family consists of a repeat found in conserved hypothetical integral membrane proteins. The function of this region and the proteins which possess it is unknown. Also, two probable transmembrane helices predicted by TMHMM2.0. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 791921 905141 Cj0844c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344251.1 791640 R 192222 CDS YP_002344252.1 218562473 905144 complement(791924..793219) 1 NC_002163.1 charges one glutamine molecule and pairs it with tRNA(Gln); glutamylglutaminyl-tRNA synthetase 793219 gltX 905144 gltX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glutamylglutaminyl-tRNA synthetase YP_002344252.1 791924 R 192222 CDS YP_002344253.1 218562474 905145 793305..794429 1 NC_002163.1 Original (2000) note: Cj0846, probable integral membrane protein, len: 374 aa; contains several probable membrane spanning regions in N-terminal half, C-terminal half is simalar to several hypothetical proteins e.g. YPBG_BACSU (259 aa), fasta scores; opt: 197 z-score: 233.7 E(): 1e-05, 28.6% identity in 238 aa overlap. 38.8% identity to HP1044; Updated (2006) note: Pfam domain PF00149 Calcineurin-like phosphoesterase and Prosite domain PS00142 Peptidase M, neutral zinc metallopeptidases,zinc-binding site identified within CDS. Also, four probable transmembrane helices predicted by TMHMM2.0. Product function modified to more specific family member based on motif matches. No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification - Misc; metallophosphoesterase 794429 905145 Cj0846 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 metallophosphoesterase YP_002344253.1 793305 D 192222 CDS YP_002344254.1 218562475 904800 794426..795226 1 NC_002163.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase 795226 psd 904800 psd Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphatidylserine decarboxylase YP_002344254.1 794426 D 192222 CDS YP_002344255.1 218562476 905149 complement(795223..795504) 1 NC_002163.1 Original (2000) note: Cj0848c, unknown, len: 93 aa; similar to hypothetical proteins e.g. TR:O34867 (EMBL:AJ000975) B. subtilis YLQH protein (93 aa), fasta scores; opt: 284 z-score: 365.6 E(): 4.5e-13, 47.3% identity in 91 aa overlap. Also similar to C-terminus of flhB possible flagellar transport proteins e.g. FLHB_ECOLI flagellar biosynthetic protein FLHB (382 aa), fasta scores; opt: 182 z-score: 232.8 E(): 1.1e-05, 41.6% identity in 77 aa overlap. 39.2% identity to HP1575 (annotated as flhB). Also similar to C-terminus of Cj0335,flhB (40.7% identity in 81 aa overlap); Updated (2006) note: Pfam domain PF01312 Bac_export_2, FlhB HrpN YscU SpaS Family identified within CDS. All of these proteins export peptides using the type III secretion system. The peptides exported are quite diverse. Functional classification - Conserved hypothetical proteins; hypothetical protein 795504 905149 Cj0848c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344255.1 795223 R 192222 CDS YP_002344256.1 218562477 905146 complement(795501..797660) 1 NC_002163.1 Original (2000) note: Cj0849c, unknown, len: 719 aa; no Hp ortholog, some similarity to Cj0041 (23.1% identity in 566 aa overlap). Contain Asn-rich region near centre; Updated (2006) note: Prosite domain PS00063 Aldo/keto reductase family active site signature found within CDS. Functional classification - Conserved hypothetical proteins; hypothetical protein 797660 905146 Cj0849c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344256.1 795501 R 192222 CDS YP_002344257.1 218562478 905150 complement(797653..798840) 1 NC_002163.1 Original (2000) note: Cj0850c, transmembrane transport protein, len: 395 aa; similar to hypothetical transport proteins e.g. YCAD_ECOLI (382 aa), fasta scores; opt: 431 z-score: 481.6 E(): 1.6e-19, 27.6% identity in 366 aa overlap. No Hp ortholog. Contains S00216 Sugar transport proteins signature 1, and Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporters; Updated (2006) note: Pfam domain PF07690 Major Facilitator Superfamily identified within CDS. Also,twelve probable transmembrane helices predicted by TMHMM2.0. The MFS family contains functions such as uniporters, symporters or antiporters. MFS proteins typically contain 12 transmembrane regions. Product modified to more specific family based on motif match. Functional classification - Transport/binding proteins -Other; MFS transport protein 798840 905150 Cj0850c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MFS transport protein YP_002344257.1 797653 R 192222 CDS YP_002344258.1 218562479 905151 complement(798818..799321) 1 NC_002163.1 Original (2000) note: Cj0851c, probable integral membrane protein, len: 167 aa; some similarity to YCIB_BUCAP integral membrane protein from Buchnera aphidicola (177 aa), fasta scores; opt: 139 z-score: 180.5 E(): 0.0093, 30.0% identity in 160 aa overlap. No Hp match; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. Paper identified giving further clues to product function. Functional classification - Membranes, lipoproteins and porins; PMID:16045618; integral membrane protein 799321 905151 Cj0851c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344258.1 798818 R 192222 CDS YP_002344259.1 218562480 905153 complement(799321..799650) 1 NC_002163.1 Original (2000) note: Cj0852c, possible integral membrane protein, len: 109 aa; some similarity to hypothetical proteins e.g. TR:O27758 (EMBL:AE000929) Methanobacterium thermoautotrophicum MTH1725 (92 aa),fasta scores; opt: 123 z-score: 165.5 E(): 0.064, 32.7% identity in 98 aa overlap. 55.0% identity to HP0307; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 799650 905153 Cj0852c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344259.1 799321 R 192222 CDS YP_002344260.1 218562481 905185 complement(799647..800921) 1 NC_002163.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 800921 hemL 905185 hemL Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glutamate-1-semialdehyde aminotransferase YP_002344260.1 799647 R 192222 CDS YP_002344261.1 218562482 905154 complement(800918..801265) 1 NC_002163.1 Original (2000) note: Cj0854c, probable periplasmic protein, len: 115 aa; 37.9% identity to HP0236. Contains N-terminal signal sequence and PS00190 Cytochrome c family heme-binding site signature. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 801265 905154 Cj0854c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344261.1 800918 R 192222 CDS YP_002344262.1 218562483 905155 801345..802193 1 NC_002163.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 802193 folD 905155 folD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_002344262.1 801345 D 192222 CDS YP_002344263.1 218562484 905156 802203..803051 1 NC_002163.1 Original (2000) note: Cj0856, lepP, probable signal peptidase I, len: 282 aa; similar to many e.g. LEP_ECOLI signal peptidase I (EC 3.4.21.89) (324 aa), fasta scores; opt: 339 z-score: 395.2 E(): 1e-14, 33.7% identity in 270 aa overlap. 46.2% identity to HP0576. Contains PS00761 Signal peptidases I signature 3 and Pfam match to entry PF00461 signal_pept_I, Signal peptidases I; Updated (2006) note: Pfam domain PF00717 Peptidase S24-like identified within CDS. Also, one probable transmembrane helix predicted by TMHMM2.0. Further support given to product function. Characterised within Escherichia coli with marginal identity score. not added to product function. Functional classification -Protein and peptide secretion; PMID:9823901; signal peptidase I 803051 lepP 905156 lepP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 signal peptidase I YP_002344263.1 802203 D 192222 CDS YP_002344264.1 218562485 905221 complement(803073..804233) 1 NC_002163.1 Original (2000) note: Cj0857c, moeA, possible molybdopterin biosynthesis protein, len: 386 aa; similar to many e.g. MOEA_ECOLI molybdopterin biosynthesis MOEA protein (411 aa), fasta scores; opt: 602 z-score: 691.1 E(): 3.4e-31, 29.2% identity in 387 aa overlap. 37.0% identity to HP0172. Also similar to Cj1519 (33.3% identity in 378 aa overlap). Contains Pfam match to entry PF00994 MoCF_biosynth, Molybdenum cofactor biosynthesis protein; Updated (2006) note: Pfam domains PF03454 MoeA C-terminal region (domain IV) and PF03453 MoeA N-terminal region (domain I and II) were identified within CDS. Further support given to product function. Characterised in Escherichia coli with marginal similaritly score. kept within product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Molybdopterin; PMID:9515915, PMID:12719427; molybdopterin biosynthesis protein 804233 moeA 905221 moeA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molybdopterin biosynthesis protein YP_002344264.1 803073 R 192222 CDS YP_002344265.1 218562486 905157 complement(804230..805486) 1 NC_002163.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 805486 murA 905157 murA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002344265.1 804230 R 192222 CDS YP_002344266.1 218562487 905158 complement(805552..805980) 1 NC_002163.1 Original (2000) note: Cj0859c, unknown, len: 142 aa; no Hp match. Gln-rich in C-term; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 805980 905158 Cj0859c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344266.1 805552 R 192222 CDS YP_002344267.1 218562488 905161 806075..806947 1 NC_002163.1 Updated (2006) note: Ten probable transmembrane helices predicted by TMHMM2.0; Original (2000) note: Cj0860, probable integral membrane protein, len: 290 aa; similar to hypothetical proteins e.g. YICL_ECOLI (307 aa), fasta scores; opt: 516 z-score: 611.4 E(): 9.3e-27, 32.0% identity in 284 aa overlap. No Hp match. Contains 2x Pfam match to entry PF00892 DUF6, Integral membrane protein. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 806947 905161 Cj0860 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344267.1 806075 D 192222 CDS YP_002344268.1 218562489 905163 complement(806934..807500) 1 NC_002163.1 Original (2000) note: Cj0861c, pabA, probable para-aminobenzoate synthase glutamine amidotransferase component II, len: 188 aa; simlar to e.g. PABA_BACSU para-aminobenzoate synthase glutamine amidotransferase component II (EC 4.1.3.-) (194 aa), fasta scores; opt: 534 z-score: 632.3 E(): 6.4e-28, 44.6% identity in 186 aa overlap, and PABA_ECOLI (187 aa), fasta scores; opt: 475 z-score: 564.2 E(): 4e-24, 36.8% identity in 185 aa overlap. 38.6% identity to HP1281 annotated as anthranilate synthase component II (trpD). Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferases class-I; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Folic acid; PMID:8096767, PMID:2123867; para-aminobenzoate synthase glutamine amidotransferase component II 807500 pabA 905163 pabA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 para-aminobenzoate synthase glutamine amidotransferase component II YP_002344268.1 806934 R 192222 CDS YP_002344269.1 218562490 905164 complement(807497..809281) 1 NC_002163.1 Original (2000) note: Cj0862c, pabB, probable para-aminobenzoate synthase component I, len: 594 aa; simlar to e.g. PABB_ECOLI para-aminobenzoate synthase component I (EC 4.1.3.-) (453 aa), fasta scores; opt: 541 z-score: 604.3 E(): 2.3e-26, 35.7% identity in 252 aa overlap. 39.3% identity to HP0293. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Folic acid; PMID:11841211, PMID:2251281; para-aminobenzoate synthase component I 809281 pabB 905164 pabB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 para-aminobenzoate synthase component I YP_002344269.1 807497 R 192222 CDS YP_002344270.1 218562491 905165 complement(809271..810335) 1 NC_002163.1 Original (2000) note: Cj0863c, xerD, probable DNA recombinase, len: 354 aa; similar to e.g. XERD_ECOLI integrase/recombinase XERD (298 aa), fasta scores; opt: 336 z-score: 389.2 E(): 2.2e-14, 29.5% identity in 298 aa overlap. 47.5% identity to HP0675 (xerC) and 30.5% identity to HP0995 (xerD). Contains Pfam match to entry PF00589 Phage_integrase, 'Phage' integrase family; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. not added to product function. Functional classification - DNA replication, restriction/modification, recombination and repair; PMID:9311978, PMID10635320, PMID11832210; DNA recombinase 810335 xerD 905165 xerD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA recombinase YP_002344270.1 809271 R 192222 CDS YP_002344271.1 218562492 904441 810963..811322 1 NC_002163.1 Original (2000) note: Cj0864, probable periplasmic protein, len: 119 aa; some similarity in C-terminus to C-terminus of thiol:disulfide interchange proteins (not including active site) e.g. TR:P97037 (EMBL:U32616) Klebsiella pneumoniae disulfide isomerase (222 aa), fasta scores; opt: 184 z-score: 240.3 E(): 4.4e-06, 36.9% identity in 84 aa overlap. No Hp match. Also similar to C-term of Cj0872 dsbA (57.3% identity in 82 aa overlap); Updated (2006) note: Interpro result (ipr012335) shows a thioredoxin fold within the CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 811322 904441 Cj0864 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344271.1 810963 D 192222 CDS YP_002344272.1 218562493 905166 811319..812119 1 NC_002163.1 Original (2000) note: Cj0865, dsbB, possible disulfide oxidoreductase, len: 266 aa; similar to e.g. DSBB_ECOLI disulfide bond formation protein B (disulfide oxidoreductase) (176 aa), fasta scores; opt: 200 z-score: 250.0 E(): 1.3e-06, 29.9% identity in 137 aa overlap (the essential Cysteine residues are conserved). No Hp match; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. This CDS has been characterised as DsbB protein (PMID:15632440). It has been demonstrated that Cj0865 is indeed a disulfide oxidoreductase. This has been shown via in silico and in vivo work in E. coli and also complementation and enzymatic tests in C. jejuni. There is an alignment of different DsbB proteins (including Cj0865) with prediction of 5 transmembranehelises (not 4 as stated in annotation); (P24-A39; F60-I74; S87-L101; F194-A214; F231-G246). There are some differences in amino acid sequences between Cj0865 and its ortholog from 81-176 (CJJ81176_0881). It is stated that its translation starts from the second Met (although the predicted N-terminal amino acid sequences of both proteins are identical), there is also an insertion of 3 amino acids at the COOH end of protein. Thus, not added to protein function. Functional classification -Protein translation and modification; PMID:15632440, PMID:7957076; disulfide oxidoreductase 812119 dsbB 905166 dsbB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 disulfide oxidoreductase YP_002344272.1 811319 D 192222 CDS YP_002344273.1 218562494 905167 813675..814316 1 NC_002163.1 Original (2000) note: Cj0872, dsbA, possible protein disulphide isomerase, len: 213 aa; some similarity to e.g. DSBA_ECOLI thiol:disulfide interchange protein DSBA precursor (208 aa), fasta scores; opt: 128 z-score: 159.8 E(): 0.13, 23.1% identity in 216 aa overlap (active site is conserved). No Hp match; Updated (2006) note: Pfam domain PF01323 DSBA-like thioredoxin domain identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score identified yet. kept within product function. Functional classification -Protein translation and modification; PMID:8494885; protein disulphide isomerase 814316 dsbA 905167 dsbA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 protein disulphide isomerase YP_002344273.1 813675 D 192222 CDS YP_002344274.1 218562495 905147 complement(814351..814563) 1 NC_002163.1 Original (2000) note: Cj0873c, unknown, len: 70 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 814563 905147 Cj0873c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344274.1 814351 R 192222 CDS YP_002344275.1 218562496 905168 complement(814539..815099) 1 NC_002163.1 Original (2000) note: Cj0874c, possible cytochrome C, len: 186 aa; very weak similarity to many cytochrome C proteins e.g. CYC_APIME cytochrome C (107 aa), fasta scores; opt: 106 z-score: 137.1 E(): 2.5, 36.5% identity in 52 aa overlap. No Hp match. Contains 2x PS00190 Cytochrome c family heme-binding site signature. Also some similarity to Cj0037c possible cytochrome C (36.0% identity in 178 aa overlap); Updated (2006) note: No specific characterisation in related bacteria with acceptable identity score. Appropriate motifs present. added to product function. Functional classification - Energy metabolism -Electron transport; cytochrome C 815099 905168 Cj0874c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytochrome C YP_002344275.1 814539 R 192222 CDS YP_002344276.1 218562497 905169 complement(815050..815337) 1 NC_002163.1 Original (2000) note: Cj0876c, probable periplasmic protein, len: 96 aa; no Hp match. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 815337 905169 Cj0876c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344276.1 815050 R 192222 CDS YP_002344277.1 218562498 905171 complement(815432..815524) 1 NC_002163.1 Original (2000) note: Cj0877c, questionable ORF,len: 30 aa; no Hp match. Functional classification -Unknown; hypothetical protein 815524 905171 Cj0877c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344277.1 815432 R 192222 CDS YP_002344278.1 218562499 905143 815545..815691 1 NC_002163.1 Original (2000) note: Cj0878, unknown, len: 48 aa; no Hp match. Functional classification - Unknown; hypothetical protein 815691 905143 Cj0878 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344278.1 815545 D 192222 CDS YP_002344279.1 218562500 904821 complement(815669..816301) 1 NC_002163.1 Original (2000) note: Cj0879c, probable periplasmic protein, len: 210 aa; no Hp match. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 816301 904821 Cj0879c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344279.1 815669 R 192222 CDS YP_002344280.1 218562501 905170 complement(816298..816540) 1 NC_002163.1 Original (2000) note: Cj0880c, unknown, len: 240 aa; no Hp match. Functional classification - Unknown; hypothetical protein 816540 905170 Cj0880c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344280.1 816298 R 192222 CDS YP_002344281.1 218562502 905173 complement(816524..817570) 1 NC_002163.1 Original (2000) note: Cj0881c, unknown, len: 348 aa; 40.6% identity to HP1042. Functional classification -Conserved hypothetical proteins; hypothetical protein 817570 905173 Cj0881c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344281.1 816524 R 192222 CDS YP_002344282.1 218562503 905174 complement(817579..819753) 1 NC_002163.1 membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 819753 flhA 905174 flhA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar biosynthesis protein FlhA YP_002344282.1 817579 R 192222 CDS YP_002344283.1 218562504 905175 complement(819740..820150) 1 NC_002163.1 Original (2000) note: Cj0883c, unknown, len: 136 aa; identical to TR:Q46090 (EMBL:U06951) Campylobacter jejuni 81-176 ORF3 in region upstream of the flhA gene. (136 aa), and similar to hypothetical proteins e.g. Y379_HAEIN (150 aa), fasta scores; opt: 174 z-score: 226.5 E(): 2.6e-05, 28.3% identity in 138 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02082 Transcriptional regulator identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation carried out yet, so kept in product function. Literature search identified papers giving further clues to product function. Functional classification - Broad regulatory functions; PMID:8063102, PMID:15066034, PMID:14985343; transcriptional regulator 820150 905175 Cj0883c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcriptional regulator YP_002344283.1 819740 R 192222 CDS YP_002344284.1 218562505 905176 820325..820597 1 NC_002163.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 820597 rpsO 905176 rpsO Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S15 YP_002344284.1 820325 D 192222 CDS YP_002344285.1 218562506 905152 complement(820683..823523) 1 NC_002163.1 Original (2000) note: Cj0886c, ftsK, probable cell division protein, len: 946 aa; 96.7% identity to YRO1_CAMJE (941 aa), and similar to e.g. FTSK_ECOLI cell division protein FTSK (1329 aa), fasta scores; opt: 803 z-score: 772.9 E(): 0, 45.2% identity in 522 aa overlap,and SP3E_BACSU stage III sporulation protein E (787 aa),fasta scores; opt: 1488 z-score: 1436.1 E(): 0, 48.3% identity in 476 aa overlap. 52.0% identity to HP1090. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Pfam domain PF01580 FtsK/SpoIIIE family identified within CDS. Further support given to product function. Three probable transmembrane helices predicted by TMHMM2.0. Similar to more than one annotated function in different genus. kept within product function. Functional classification - Cell division; PMID:8063102, PMID:11778051, PMID:7592387; cell division protein 823523 ftsK 905152 ftsK Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cell division protein YP_002344285.1 820683 R 192222 CDS YP_002344286.1 218562507 905178 complement(823633..825885) 1 NC_002163.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; lagellar hook-associated protein FlgL 825885 flgL 905178 flgL Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lagellar hook-associated protein FlgL YP_002344286.1 823633 R 192222 CDS YP_002344287.1 218562508 904350 complement(826268..828199) 1 NC_002163.1 Original (2000) note: Cj0888c, ABC transport system ATP-binding protein, len: 643 aa; similar to UUP_ECOLI ABC transporter atp-binding protein UUP (635 aa), fasta scores; opt: 744 z-score: 763.9 E(): 0, 37.1% identity in 634 aa overlap. No Hp ortholog. Contains 2x PS00017 ATP/GTP-binding site motif A (P-loop), 2x PS00211 ABC transporters family signature, and 2x Pfam match to entry PF00005 ABC_tran; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Transport/binding proteins - Other; PMID:9139905; ABC transporter ATP-binding protein 828199 904350 Cj0888c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter ATP-binding protein YP_002344287.1 826268 R 192222 CDS YP_002344288.1 218562509 905181 complement(828203..829492) 1 NC_002163.1 Original (2000) note: Cj0889c, probable sensory transduction histidine kinase, len: 429 aa; similar in C-terminus to many e.g. ENVZ_ECOLI osmolarity sensor protein ENVZ (450 aa), fasta scores; opt: 210 z-score: 229.3 E(): 1.8e-05. 26.5% identity in 204 aa overlap No Hp ortholog. Contains two probable transmembrane domains in N-terminus and Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain; Updated (2006) note: Pfam domain PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase identified within CDS. Further support given to product function. Some characterisation in Bacillus subtilitis, however,identity score not acceptable. kept in product function. Functional classification - Signal transduction; PMID:8002614, PMID:14612242, PMID:12890034; sensory trasnduction histidine kinase 829492 905181 Cj0889c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sensory trasnduction histidine kinase YP_002344288.1 828203 R 192222 CDS YP_002344289.1 218562510 905187 complement(829486..830148) 1 NC_002163.1 Original (2000) note: Cj0890c, probable sensory transduction transcriptional regulator, len: 220 aa; similar to many e.g. PHOB_SHIFL phosphate regulon transcriptional regulator (229 aa), fasta scores; opt: 396 z-score: 471.5 E(): 5.8e-19, 29.3% identity in 222 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain and Pfam match to entry PF00486 trans_reg_C,Transcriptional regulatory protein, C terminal; Updated (2006) note: Characterisation within more than one genus, however, identity scores were marginal. kept within product function. Functional classification - Signal transduction; PMID:9141682; sensory transduction transcriptional regulator 830148 905187 Cj0890c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sensory transduction transcriptional regulator YP_002344289.1 829486 R 192222 CDS YP_002344290.1 218562511 905182 complement(830135..831718) 1 NC_002163.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 831718 serA 905182 serA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 D-3-phosphoglycerate dehydrogenase YP_002344290.1 830135 R 192222 CDS YP_002344291.1 218562512 905183 complement(831715..832203) 1 NC_002163.1 Original (2000) note: Cj0892c, probable periplasmic protein, len: 162 aa; no Hp match. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 832203 905183 Cj0892c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344291.1 831715 R 192222 CDS YP_002344292.1 218562513 905184 complement(832203..833873) 1 NC_002163.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 833873 rpsA 905184 rpsA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S1 YP_002344292.1 832203 R 192222 CDS YP_002344293.1 218562514 905189 complement(834005..834838) 1 NC_002163.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 834838 ispH 905189 ispH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_002344293.1 834005 R 192222 CDS YP_002344294.1 218562515 904338 complement(834828..836114) 1 NC_002163.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 836114 aroA 904338 aroA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 3-phosphoshikimate 1-carboxyvinyltransferase YP_002344294.1 834828 R 192222 CDS YP_002344295.1 218562516 905191 complement(836111..838432) 1 NC_002163.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 838432 pheT 905191 pheT Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phenylalanyl-tRNA synthetase subunit beta YP_002344295.1 836111 R 192222 CDS YP_002344296.1 218562517 905193 complement(838429..839421) 1 NC_002163.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 839421 pheS 905193 pheS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phenylalanyl-tRNA synthetase subunit alpha YP_002344296.1 838429 R 192222 CDS YP_002344297.1 218562518 905194 839544..839909 1 NC_002163.1 Original (2000) note: Cj0898, HIT-family protein,len: 121 aa; similar to many members of the HIT family e.g. IPK1_HUMAN HINT protein (protein kinase C inhibitor 1) (125 aa), fasta scores; opt: 286 z-score: 385.9 E(): 3.4e-14, 40.6% identity in 106 aa overlap, and YCFF_ECOLI HYPOTHETICAL 13.2 KD PROTEIN HIT-LIKE PROTE (119 aa),fasta scores; opt: 276 z-score: 373.2 E(): 1.7e-13, 38.2% identity in 110 aa overlap. 56.6% identity to HP0404. Contains Pfam match to entry PF01230 HIT, HIT family; Updated (2006) note: Specific characterisation has not been carried out, so kept in product function. Functional classification - Misc; histidine triad (HIT) family protein 839909 905194 Cj0898 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 histidine triad (HIT) family protein YP_002344297.1 839544 D 192222 CDS YP_002344298.1 218562519 905197 complement(839939..840508) 1 NC_002163.1 Original (2000) note: Cj0899c, thiJ, probable 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein, len: 189 aa; simlar to e.g. THIJ_ECOLI 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme (198 aa), fasta scores; opt: 265 z-score: 330.3 E(): 4.2e-11, 32.6% identity in 181 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF01965 DJ-1/PfpI family identified within CDS. Further support given to product function. Characterised in Escherichia coli with marginal identity score. not added to protein function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Thiamine; PMID:10075431; 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein 840508 thiJ 905197 thiJ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein YP_002344298.1 839939 R 192222 CDS YP_002344299.1 218562520 905195 complement(840501..840680) 1 NC_002163.1 Original (2000) note: Cj0900c, small hydrophobic protein, len: 59 aa; 29.8% identity to HP0085. Functional classification - Conserved hypothetical proteins; hypothetical protein 840680 905195 Cj0900c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344299.1 840501 R 192222 CDS YP_002344300.1 218562521 905200 840763..841506 1 NC_002163.1 Original (2000) note: Cj0901, probable amino acid ABC tansporter permease, len: 247 aa; similar to many e.g. YQIY_BACSU probable amino-acid ABC transporter permease (219 aa), fasta scores; opt: 552 z-score: 683.2 E(): 9.3e-31, 43.6% identity in 204 aa overlap. 28.6% identity to HP0939. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature, and Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification -Transport/binding proteins - Amino acids and amines; amino acid ABC tansporter permease 841506 905200 Cj0901 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amino acid ABC tansporter permease YP_002344300.1 840763 D 192222 CDS YP_002344301.1 218562522 905198 841499..842227 1 NC_002163.1 Original (2000) note: Cj0902, glnQ, probable glutamine transport ATP-binding protein, len: 247 aa; highly similar to e.g. GLNQ_BACST glutamine transport ATP-binding protein (242 aa), fasta scores; opt: 940 z-score: 1074.4 E(): 0, 56.2% identity in 242 aa overlap. No Hp ortholog. Also similar to Cj0469 (52.9% identity in 238 aa overlap). Contains S00017 ATP/GTP-binding site motif A (P-loop), S00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran, ABC transporters; Updated (2006) note: Characterised in Bacillus stearothermophilus with acceptable identity score. kept within product function as not sure whether exact substrate is used in Campylobacter jejuni. Functional classification - Transport/binding proteins -Amino acids and amines; PMID:1856180; glutamine transport ATP-binding protein 842227 glnQ 905198 glnQ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glutamine transport ATP-binding protein YP_002344301.1 841499 D 192222 CDS YP_002344302.1 218562523 905201 complement(842255..843721) 1 NC_002163.1 Original (2000) note: Cj0903c, probable amino-acid transport protein, len: 488 aa; simlar to many hypothetical membaer of the sodium:alanine symporter family e.g. ALST_BACSU amino acid carrier protein ALST (465 aa), fasta scores; opt: 821 z-score: 946.6 E(): 0,41.9% identity in 473 aa overlap. 33.6% identity to HP0942. Contains PS00873 Sodium:alanine symporter family signature, and Pfam match to entry PF01235 Na_Ala_symp,Sodium:alanine symporter family; Updated (2006) note: Nine probable transmembrane helices predicted for TMHMM2.0. Further support given to product function. No specfic characterisation with acceptable identity score carried out yet. kept within product function along with amino-acid designation as not sure whether exact substrate is used in Campylobacter jejuni. Literature search identified paper giving further clues about product function. Functional classification - Transport/binding proteins - Amino acids and amines; PMID:15066034; amino-acid transport protein 843721 905201 Cj0903c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amino-acid transport protein YP_002344302.1 842255 R 192222 CDS YP_002344303.1 218562524 905203 complement(843825..844292) 1 NC_002163.1 Original (2000) note: Cj0904c, probable RNA methylase, len: 155 aa; similar to members of the spoU family e.g. YIBK_ECOLI (157 aa), fasta scores; opt: 373 z-score: 490.5 E(): 5e-20, 43.3% identity in 150 aa overlap. No Hp match. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family; Updated (2006) note: kept within product function, as full characterisation has not been carried out. Functional classification - RNA synthesis, RNA modification and DNA transcription; RNA methylase 844292 905203 Cj0904c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 RNA methylase YP_002344303.1 843825 R 192222 CDS YP_002344304.1 218562525 905209 complement(844295..845281) 1 NC_002163.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 845281 alr 905209 alr Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 alanine racemase YP_002344304.1 844295 R 192222 CDS YP_002344305.1 218562526 905204 complement(845282..846259) 1 NC_002163.1 Original (2000) note: Cj0906c, probable periplasmic protein, len: 325 aa; similar to hypothetical proteins e.g. TR:O66569 (EMBL:AE000677) Aquifex aeolicus AQ_183 (397 aa), fasta scores; opt: 380 z-score: 432.9 E(): 8.2e-17, 31.1% identity in 270 aa overlap. 36.6% identity to HP0518. Contains probable N-terminal signal sequence; Updated (2006) note: Paper identified linking protein to glycoprotein. Functional classification -Miscellaneous periplasmic proteins; PMID:12186869; periplasmic protein 846259 905204 Cj0906c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344305.1 845282 R 192222 CDS YP_002344306.1 218562527 905208 846415..846885 1 NC_002163.1 Original (2000) note: Cj0908, probable periplasmic protein, len: 156 aa; no Hp match. Contains probable N-terminal signal sequence. Similar to downstream gene Cj0910 (41.3% identity in 143 aa overlap). Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 846885 905208 Cj0908 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344306.1 846415 D 192222 CDS YP_002344307.1 218562528 905210 846971..847390 1 NC_002163.1 Original (2000) note: Cj0909, probable periplasmic protein, len: 139 aa; similar to TR:O67294 (EMBL:AE000731) Aquifex aeolicus AQ_1253 (151 aa), fasta scores; opt: 208 z-score: 273.4 E(): 6.3e-08, 34.3% identity in 134 aa overlap. No Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF04314 Protein of unknown function (DUF461) identified within CDS. This Pfam is linked to being a membrane or periplasmic protein. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 847390 905210 Cj0909 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344307.1 846971 D 192222 CDS YP_002344308.1 218562529 905190 847394..847846 1 NC_002163.1 Original (2000) note: Cj0910, probable periplasmic protein, len: 150 aa; no Hp match. Contains probable N-terminal signal sequence. Similar to downstream gene Cj0908 (41.3% identity in 145 aa overlap). Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 847846 905190 Cj0910 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344308.1 847394 D 192222 CDS YP_002344309.1 218562530 905211 847843..848403 1 NC_002163.1 Original (2000) note: Cj0911, probable periplasmic protein, len: 186 aa; similar to bacterial hypotheticals e.g. TR:O67113 (EMBL:AE000717) Aquifex aeolicus AQ_988 (197 aa), fasta scores; opt: 260 z-score: 314.1 E(): 3.4e-10, 28.1% identity in 167 aa overlap, and to N-terminus of eukaryotic proteins e.g. SCO1_YEAST SCO1 protein precursor (295 aa), opt: 213 z-score: 257.2 E(): 5e-07, 32.1% identity in 137 aa overlap. No Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF02630 SCO1/SenC identified within CDS. Characterization has been carried out in Rhodobacter capsulatus, however, identity scores was unnacceptable. kept in product function. Functional classification - Miscellaneous periplasmic proteins; PMID:7592491; periplasmic protein 848403 905211 Cj0911 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344309.1 847843 D 192222 CDS YP_002344310.1 218562531 906009 complement(848410..849309) 1 NC_002163.1 Original (2000) note: Cj0912c, cysM, cysteine synthase, len: 299 aa; 98.7% identical to CYSM_CAMJE cysteine synthase B (EC 4.2.99.8) (299 aa), and similar to many e.g. CYSK_BACSU CYSTEINE SYNTHASE (EC 4.2.99.8) (307 aa), fasta scores; opt: 907 z-score: 1020.2 E(): 0, 48.5% identity in 305 aa overlap. 38.9% identity to HP0107. Contains PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site, PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site, and Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependant enzymes; Updated (2006) note: Characterised in Campylobacter jejuni, so not added to product function. Functional classification - Amino acid biosynthesis -Serine family; PMID:9034314; cysteine synthase 849309 cysM 906009 cysM Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cysteine synthase YP_002344310.1 848410 R 192222 CDS YP_002344311.1 218562532 905212 complement(849436..849732) 1 NC_002163.1 Original (2000) note: Cj0913c, hupB, DNA-binding protein HU homolog, len: 98 aa; identical to TR:Q46121 (EMBL:L25627) DNA-binding protein HU homolog (98 aa), and highly similar to many e.g. DBHB_ECOLI DNA-binding protein HU-beta (90 aa), fasta scores; opt: 272 z-score: 356.7 E(): 1.4e-12, 44.9% identity in 89 aa overlap. 42.2% identity to HP0835. Contains Pfam match to entry PF00216 Bac_DNA_binding, Bacterial DNA-binding protein; Updated (2006) note: Characterised in Campylobacter jejuni and many others. not added to product function. Functional classification - Synthesis and modification of macromolecules - Nucleoproteins; PMID:8063109; DNA-binding protein HU 849732 hupB 905212 hupB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA-binding protein HU YP_002344311.1 849436 R 192222 CDS YP_002344312.1 218562533 905214 complement(849834..851666) 1 NC_002163.1 Original (2000) note: Cj0914c, ciaB, unknown function, len: 610 aa; no Hp match. Product is translocated into host cells. Mutants fail to translocate,and fail to translocate other proteins. Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature; Updated (2006) note: Papers attached giving further information regarding this CDS. Functional classification - Pathogenicity; PMID:10361274, PMID:10540297, PMID:10659361,PMID:15722140; CiaB protein 851666 ciaB 905214 ciaB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CiaB protein YP_002344312.1 849834 R 192222 CDS YP_002344313.1 218562534 905254 851728..852141 1 NC_002163.1 Original (2000) note: Cj0915, possible hydrolase,len: 137 aa; similar to prokaryotic hypotheticals e.g. YCIA_ECOLI (132 aa), fasta scores; opt: 351 z-score: 440.7 E(): 3e-17, 41.5% identity in 123 aa overlap, and to eukaryotic acyl-CoA hydrolases e.g. THCC_HUMAN cytosolic acyl coenzyme A thioester hydrolase (372 aa), fasta scores; opt: 174 z-score: 220.2 E(): 5.7e-05, 31.6% identity in 114 aa overlap. 25.4% identity to HP0891 (VDLD_HELPY); Updated (2006) note: Pfam domain PF03061 Thioesterase superfamily identified within CDS. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Functional classification - Misc; PMID:12426338; hydrolase 852141 905254 Cj0915 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hydrolase YP_002344313.1 851728 D 192222 CDS YP_002344314.1 218562535 905180 complement(852181..852378) 1 NC_002163.1 Original (2000) note: Cj0916c, unknown, len: 65 aa; similar to two hypothetical E. coli proteins; YBDD_ECOLI (65 aa), fasta scores; opt: 154 z-score: 227.0 E(): 2.5e-05, 41.3% identity in 46 aa overlap, and YJIX_ECOLI (67 aa), fasta scores; opt: 141 z-score: 209.5 E(): 0.00023, 35.8% identity in 67 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF04328 Protein of unknown function (DUF466) identified within CDS. Conserved added to product function. Functional classification -Conserved hypothetical proteins; hypothetical protein 852378 905180 Cj0916c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344314.1 852181 R 192222 CDS YP_002344315.1 218562536 905216 complement(852359..854470) 1 NC_002163.1 Original (2000) note: Cj0917c, cstA, integral membrane protein, homolog of carbon starvation protein A,len: 703 aa; highly similar to e.g. CSTA_ECOLI carbon starvation protein A (701 aa), fasta scores; opt: 2523 z-score: 2823.2 E(): 0, 56.0% identity in 707 aa overlap. 65.6% identity to HP1168; Updated (2006) note: Pfam domain PF02554 Carbon starvation protein CstA identified within CDS. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Membranes, lipoproteins and porins; PMID:1848300; integral membrane protein 854470 cstA 905216 cstA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344315.1 852359 R 192222 CDS YP_002344316.1 218562537 905217 complement(854637..855566) 1 NC_002163.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 855566 prsA 905217 prsA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribose-phosphate pyrophosphokinase YP_002344316.1 854637 R 192222 CDS YP_002344317.1 218562538 904985 complement(855674..856333) 1 NC_002163.1 Original (2000) note: Cj0919c, probable ABC-type amino-acid transporter permease, len: 219 aa; similar to many e.g. GLTK_ECOLI glutamate/aspartate transport system permease (224 aa), fasta scores; opt: 380 z-score: 457.9 E(): 3.3e-18, 32.6% identity in 221 aa overlap. No Hp ortholog. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign., and Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component; Updated (2006) note: Three probable transmembrane helices predicted by TMHMM2.0. No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification - Transport/binding proteins - Amino acids and amines; PMID:16689801; ABC-type amino-acid transporter permease 856333 904985 Cj0919c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC-type amino-acid transporter permease YP_002344317.1 855674 R 192222 CDS YP_002344318.1 218562539 905218 complement(856344..857096) 1 NC_002163.1 Original (2000) note: Cj0920c, probable ABC-type amino-acid transporter permease, len: 250 aa; similar to many e.g. YCKA_BACSU probable amino-acid ABC transporter permease (226 aa), fasta scores; opt: 448 z-score: 560.9 E(): 6e-24, 32.0% identity in 219 aa overlap. No Hp ortholog. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign., and Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component; Updated (2006) note: Three probable transmembrane helices predicted by TMHMM2.0. No specific characterisation has been carried out yet. kept within product function. Functional classification -Transport/binding proteins - Amino acids and amines; PMID:16689801; ABC-type amino-acid transporter permease 857096 905218 Cj0920c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC-type amino-acid transporter permease YP_002344318.1 856344 R 192222 CDS YP_002344319.1 218562540 906008 complement(857098..857877) 1 NC_002163.1 PEB1; bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein 857877 peb1A 906008 peb1A Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein YP_002344319.1 857098 R 192222 CDS YP_002344320.1 218562541 905220 complement(857899..858627) 1 NC_002163.1 Original (2000) note: Cj0922c, pebC, probable ABC-type amino-acid transporter ATP-binding protein, len: 242 aa; 98.8% identical to PEBC_CAMJE, and similar to many e.g. GLNQ_BACST glutamine transport ATP-binding protein (242 aa), fasta scores; opt: 1013 z-score: 1161.8 E(): 0,64.6% identity in 243 aa overlap. No Hp ortholog. Contains PS00211 ABC transporters family signature, PS00017 ATP/GTP-binding site motif A (P-loop), and Pfam match to entry PF00005 ABC_tran, ABC transporters; Updated (2006) note: Characterised within Campylobacter jejuni. not added to product function. Functional classification - Transport/binding proteins - Amino acids and amines; PMID:16689801; amino-acid ABC transporter ATP-binding protein 858627 pebC 905220 pebC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amino-acid ABC transporter ATP-binding protein YP_002344320.1 857899 R 192222 CDS YP_002344321.1 218562542 905222 complement(858763..859551) 1 NC_002163.1 Original (2000) note: Cj0923c, cheR, probable MCP protein methyltransferase, len: 262 aa; identical to YPEB_CAMJE, and similar to e.g. CHER_BACSU chemotaxis protein methyltransferase (EC 2.1.1.80) (256 aa), fasta scores; opt: 357 z-score: 432.6 E(): 8.5e-17, 31.6% identity in 231 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF01739 CheR methyltransferase, SAM binding domain and PF03705 CheR methyltransferase, all-alpha domain were identified within CDS. Further support given to product function. Characterised in more than one genus, however, identity scores were marginal. kept within product function. Functional classification - Chemotaxis and mobility; PMID:8244966, PMID:8360165, PMID:3510184,PMID:11669626; MCP protein methyltransferase 859551 cheR 905222 cheR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MCP protein methyltransferase YP_002344321.1 858763 R 192222 CDS YP_002344322.1 218562543 904926 complement(859567..860121) 1 NC_002163.1 Original (2000) note: Cj0924c, cheB' probable MCP protein-glutamate methylesterase, len: 184 aa; similar to the methylesterase domain of e.g. CHEB_ECOLI protein-glutamate methylesterase (EC 3.1.1.61) (349 aa),fasta scores; opt: 339 z-score: 430.2 E(): 1.1e-16, 34.4% identity in 183 aa overlap. Note that the 'response reciever domain' normally found in cheB is not present. No Hp match; Updated (2006) note: Characterised within Escherichia coli, however, identity scores were marginal. Possible truncated protein as missing receiver domain of CheB protein. kept within product function. Functional classification - Chemotaxis and mobility; PMID:3280143, PMID:3510184, PMID:2188960,PMID:8244966; MCP protein-glutamate methylesterase 860121 cheB' 904926 cheB' Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MCP protein-glutamate methylesterase YP_002344322.1 859567 R 192222 CDS YP_002344323.1 218562544 905223 860287..860724 1 NC_002163.1 Original (2000) note: Cj0925, rpiB, probable ribose 5-phosphate isomerase, len: 145 aa; highly similar to e.g. RPIB_ECOLI ribose 5-phosphate isomerase B (EC 5.3.1.6) (149 aa), fasta scores; opt: 399 z-score: 505.9 E(): 7e-21, 45.0% identity in 140 aa overlap. 45.0% identity to HP0574, misannotated as galactosidase acetyltransferase (lacA); Updated (2006) note: Prosite domain PS00237 G_PROTEIN_RECEP_F1_1, Rhodopsin-like GPCR superfamily and Pfam domain PF02502 Ribose/Galactose Isomerase were identified within CDS. Further support given to product function. Characterised in Escherichia coli with acceptable identity score. removed from product funtion. Functional classification - Energy metabolism -Pentose phosphate pathway - Non-oxidative branch; PMID:8576032,PMID:14499611; ribose 5-phosphate isomerase 860724 rpiB 905223 rpiB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribose 5-phosphate isomerase YP_002344323.1 860287 D 192222 CDS YP_002344324.1 218562545 905225 860724..861056 1 NC_002163.1 Original (2000) note: Cj0926, possible membrane protein, len: 110 aa; 50.0% identity to HP0573. Contains possible transmembrane domain at N-terminus; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; hypothetical protein 861056 905225 Cj0926 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344324.1 860724 D 192222 CDS YP_002344325.1 218562546 905205 861053..861601 1 NC_002163.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 861601 apt 905205 apt Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 adenine phosphoribosyltransferase YP_002344325.1 861053 D 192222 CDS YP_002344326.1 218562547 905226 861620..862216 1 NC_002163.1 Original (2000) note: Cj0928, probable integral membrane protein, len: 198 aa; similar to members of the dedA family of hypothetical integral membrane proteins e.g. YOHD_ECOLI (192 aa), fasta scores; opt: 303 z-score: 394.8 E(): 1.1e-14, 29.1% identity in 172 aa overlap, and DEDA_ECOLI DEDA protein (219 aa), fasta scores; opt: 169 z-score: 224.4 E(): 3.3e-05, 25.3% identity in 162 aa overlap. 61.4% identity to HP0571. Contains Pfam match to entry PF00597 DedA, DedA family. Also similar to Cj1210 (27.1% identity in 177 aa overlap); Updated (2006) note: Five probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 862216 905226 Cj0928 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344326.1 861620 D 192222 CDS YP_002344327.1 218562548 904492 862213..863664 1 NC_002163.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 863664 pepA 904492 pepA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 leucyl aminopeptidase YP_002344327.1 862213 D 192222 CDS YP_002344328.1 218562549 904351 863661..864764 1 NC_002163.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 864764 904351 Cj0930 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GTP-dependent nucleic acid-binding protein EngD YP_002344328.1 863661 D 192222 CDS YP_002344329.1 218562550 905111 complement(864786..866168) 1 NC_002163.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 866168 argH 905111 argH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 argininosuccinate lyase YP_002344329.1 864786 R 192222 CDS YP_002344330.1 218562551 905227 complement(866178..867752) 1 NC_002163.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 867752 pckA 905227 pckA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoenolpyruvate carboxykinase YP_002344330.1 866178 R 192222 CDS YP_002344331.1 218562552 905229 complement(867765..869564) 1 NC_002163.1 Original (2000) note: Cj0933c, pycB, possible possible pyruvate carboxylase B subunit, len: 599 aa; similar to TR:O27179 (EMBL:AE000942) Methanobacterium thermoautotrophicum characterised pyruvate carboxylase B (EC 6.4.1.1) (568 aa), fasta scores; opt: 425 z-score: 482.7 E(): 1.4e-19, 29.1% identity in 601 aa overlap. Also similar to other biotin-requiring decarboxlases e.g. DCOA_SALTY oxaloacetate decarboxylase alpha chain (590 aa), fasta scores; opt: 515 z-score: 584.5 E(): 2.9e-25,27.3% identity in 605 aa overlap, and C-terminus of PYC1_YEAST pyruvate carboxylase 1 (1178 aa), fasta scores; opt: 434 z-score: 488.3 E(): 6.7e-20, 24.2% identity in 631 aa overlap. No Hp match. Contains S00188 Biotin-requiring enzymes attachment site and Pfam match to entry PF00364 biotin_req_enzy, Biotin-requiring enzymes; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification -Central intermediary metabolism - Gluconeogenesis; pyruvate carboxylase B subunit 869564 pycB 905229 pycB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 pyruvate carboxylase B subunit YP_002344331.1 867765 R 192222 CDS YP_002344332.1 218562553 905237 complement(869596..870936) 1 NC_002163.1 Original (2000) note: Cj0934c, probable transmembrane transport protein, len: 446 aa; similar to members of the sodium:neurotransmitter symporter family e.g. YD19_METJA hypothetical sodium-dependent transporter MJ1319 (492 aa), fasta scores; opt: 628 z-score: 711.7 E(): 2.4e-32, 27.4% identity in 457 aa overlap. 42.6% identity to HP0498. Also similar to Cj0935c (51.0% identity in 441 aa overlap) and Cj0601c (28.2% identity in 454 aa overlap); Updated (2006) note: Pfam domain PF00209 Sodium:neurotransmitter symporter family identified within CDS. Also, eleven probable transmembrane helices predicted by TMHMM2.0. Product function modified to more specfific family member based on motif identification. No specific characterisation has been carried out, so has kept within product function. Functional classification -Transport/binding proteins - Other; sodium:amino-acid symporter family protein 870936 905237 Cj0934c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sodium:amino-acid symporter family protein YP_002344332.1 869596 R 192222 CDS YP_002344333.1 218562554 906006 complement(870949..872283) 1 NC_002163.1 Original (2000) note: Cj0935c, probable transmembrane transport protein, len: 444 aa; similar to members of the sodium:neurotransmitter symporter family e.g. YG90_HAEIN hypothetical sodium-dependent transporter HI1690 (457 aa), fasta scores; opt: 694 z-score: 771.9 E(): 0, 33.0% identity in 449 aa overlap. 40.4% identity to HP0497. Pfam match to entry PF00209 SNF,Sodium:neurotransmitter symporter family. Also similar to Cj0934c (51.0% identity in 441 aa overlap) and Cj0601c (32.6% identity in 451 aa overlap); Updated (2006) note: Pfam domain PF00209 Sodium:neurotransmitter symporter family identified within CDS. Also, eleven probable transmembrane helices predicted by TMHMM2.0. Product function modified to more specfific family member based on motif identification. No specific characterisation has been carried out, so has kept within product function. Functional classification -Transport/binding proteins - Other; sodium:amino-acid symporter family protein 872283 906006 Cj0935c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sodium:amino-acid symporter family protein YP_002344333.1 870949 R 192222 CDS YP_002344334.1 218562555 905243 872516..872854 1 NC_002163.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 872854 atpE 905243 atpE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 F0F1 ATP synthase subunit C YP_002344334.1 872516 D 192222 CDS YP_002344335.1 218562556 905231 873171..874082 1 NC_002163.1 Original (2000) note: Cj0937, probable integral membrane protein, len: 303 aa; simimlar to hypothetical membrane proteins e.g. YA31_METJA MJ1031 (308 aa), fasta scores; opt: 379 z-score: 446.4 E(): 1.4e-17, 26.1% identity in 318 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03547 Auxin Efflux Carrier identified within CDS. Also, ten probable transmembrane helices predicted by TMHMM2.0. PProteins in this group are mostly uncharacterised and of unknown function. Functional classification - Membranes,lipoproteins and porins; integral membrane protein 874082 905231 Cj0937 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344335.1 873171 D 192222 CDS YP_002344336.1 218562557 905232 complement(874090..877602) 1 NC_002163.1 Original (2000) note: Cj0938c, aas, probable 2-acylglycerophosphoethanolamine acyltransferase / acyl-acyl carrier protein synthetase, len: 1170 aa; contains 2 domains; C-terminal domain (420 aa to end) is simlar to the bifunctional enzyme AAS_ECOLI 2-acylglycerophosphoethanolamine acyltransferase / acyl-acyl carrier protein synthetase (719 aa), fasta scores; opt: 438 z-score: 471.6 E(): 5.7e-19, 31.0% identity in 762 aa overlap; N-terminal domain contains approx 12 transmembrane domains, and is similar to the hypothetical membrane protein immediately upstreram of the E. coli aas; YGED_ECOLI; wublastp scores E= 3.5e-12, 25% in 192 aa overlap and 31% identity in 146 aa overlap. No Hp match. Contains PS00455 AMP-binding domain signature, and Pfam match to entry PF00501 AMP-binding,AMP-binding enzyme; Updated (2006) note: Now contains additional Pfam domains in centre of CDS, PF01553 Acyltransferase and N-terminal domain PF07690 Major Facilitator Superfamily. Characterisation has been carried out within Escherichia coli, however, sequence alignment is only partial. kept within product function. Functional classification - Fatty acid biosynthesis; PMID:10733890; 2-acyl-glycerophospho-ethanolamine acyltransferase 877602 aas 905232 aas Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 2-acyl-glycerophospho-ethanolamine acyltransferase YP_002344336.1 874090 R 192222 CDS YP_002344337.1 218562558 905233 complement(877647..878027) 1 NC_002163.1 Original (2000) note: Cj0939c, unknown, len: 126 aa; 29.5% identity to HP1065. Functional classification -Conserved hypothetical proteins; hypothetical protein 878027 905233 Cj0939c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344337.1 877647 R 192222 CDS YP_002344338.1 218562559 905236 complement(878828..879613) 1 NC_002163.1 Original (2000) note: Cj0940c, glnP, probable glutamine transport system permease, len: 261 aa; similar to many e.g. GLNP_ECOLI glutamine transport system permease (219 aa), fasta scores; opt: 414 z-score: 509.0 E(): 4.7e-21, 37.5% identity in 216 aa overlap. No Hp otholog. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign., and Pfam match to entry PF00528 BPD_transp,Binding-protein-dependent transport systems inner membrane component; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Not fully characterised, so kept in product function. Functional classification - Transport/binding proteins - Amino acids and amines; glutamine transport system permease 879613 glnP 905236 glnP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glutamine transport system permease YP_002344338.1 878828 R 192222 CDS YP_002344339.1 218562560 904433 complement(879636..880841) 1 NC_002163.1 Original (2000) note: Cj0941c, probable integral membrane protein, len: 401 aa; similar to many hypothetical membrane proteins e.g. YCFU_ECOLI(399 aa),fasta scores; opt: 414 z-score: 478.9 E(): 2.2e-19, 22.1% identity in 408 aa overlap. 53.5% identity to HP0787; Updated (2006) note: Pfam domain PF02687 Predicted permease identified within CDS. Also, four probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member based on motif match. Not specific characterisation has been carried out yet, so kept within product function. Functional classification - Transport/binding proteins - Other; permease 880841 904433 Cj0941c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 permease YP_002344339.1 879636 R 192222 CDS YP_002344340.1 218562561 905172 complement(880838..883426) 1 NC_002163.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 883426 secA 905172 secA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 preprotein translocase subunit SecA YP_002344340.1 880838 R 192222 CDS YP_002344341.1 218562562 905238 883526..884035 1 NC_002163.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 884035 lolA 905238 lolA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 outer-membrane lipoprotein carrier protein YP_002344341.1 883526 D 192222 CDS YP_002344342.1 218562563 904376 complement(884032..884766) 1 NC_002163.1 Original (2000) note: Cj0944c, probable periplasmic protein, len: 244 aa; no Hp match; Updated (2006) note: Paper identified linking protein to glycoprotein. Functional classification -Miscellaneous periplasmic proteins; PMID:12186869; periplasmic protein 884766 904376 Cj0944c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344342.1 884032 R 192222 CDS YP_002344343.1 218562564 905207 complement(884776..886119) 1 NC_002163.1 Original (2000) note: Cj0945c, possible helicase,len: 447 aa; similar to the C-terminus of members of the eukaryotic RAD3/XPD helicase subfamily, e.g. PIF1_YEAST mitochondrial DNA repair and recombination protein (857 aa), fasta scores; opt: 193 z-score: 220.7 E(): 5.4e-05,29.6% identity in 324 aa overlap. No Hp match. Contains S00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification -DNA replication, restriction/modification, recombination and repair; helicase 886119 905207 Cj0945c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 helicase YP_002344343.1 884776 R 192222 CDS YP_002344344.1 218562565 905239 886168..887514 1 NC_002163.1 Original (2000) note: Cj0946, probable lipoprotein,len: 448 aa; 29.0% identity to HP0087. Contains probable N-terminal signal sequence with appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site, and Pfam match to entry PF00877 NLPC_P60, NLP/P60 family. Functional classification - Membranes,lipoproteins and porins; lipoprotein 887514 905239 Cj0946 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002344344.1 886168 D 192222 CDS YP_002344345.1 218562566 905240 complement(887526..888398) 1 NC_002163.1 Original (2000) note: Cj0947c, probable hydrolase,len: 290 aa; similar to prokaryotic hypothetical hydrolases, and to e.g. BUP_RAT beta-ureidopropionase (393 aa), fasta scores; opt: 319 z-score: 392.0 E(): 1.6e-14,26.0% identity in 304 aa overlap. 60.9% identity to HP0757; Updated (2006) note: Pfam domain PF00795 Carbon-nitrogen hydrolase identified within CDS. Product modified to more specific family member based on motif match. Specific characterisation has been carried out yet,so kept in product funciton. Functional classification - Misc; carbon-nitrogen hydrolase 888398 905240 Cj0947c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 carbon-nitrogen hydrolase YP_002344345.1 887526 R 192222 CDS YP_002344346.1 218562567 905780 complement(888395..889282) 1 NC_002163.1 Original (2000) note: Cj0948c, possible transmembrane transport protein, len: 295 aa; similar to members of the UPF0018 family, e.g. YIIP_ECOLI (300 aa),fasta scores; opt: 564 z-score: 671.3 E(): 4.3e-30, 31.8% identity in 292 aa overlap, and to cation efflux proteins e.g. CZCD_ALCEU cation efflux system protein CZCD (316 aa), fasta scores; opt: 262 z-score: 316.4 E(): 2.5e-10,22.3% identity in 273 aa overlap. No Hp match. Also similar to Cj1163c (24.7% identity in 279 aa overlap); Updated (2006) note: Pfam domain PF01545 Cation efflux family identified within CDS. Six probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterisation within more than one species e.g. Klebsiella pneumoniae and some Escherichia coli. kept in product function. Functional classification - Drug/analogue sensitivity; PMID:12019132, PMID:15549269; cation efflux family protein 889282 905780 Cj0948c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cation efflux family protein YP_002344346.1 888395 R 192222 CDS YP_002344347.1 218562568 905241 complement(889279..890256) 1 NC_002163.1 Original (2000) note: Cj0949c, unknown, len: 325 aa; similar to hypothetical proteins e.g. TR:O86509 (EMBL:AL031124) Streptomyces coelicolor SC1C2.08 (339 aa),fasta scores; opt: 283 z-score: 328.5 E(): 5.3e-11, 24.3% identity in 333 aa overlap. 45.5% identity to HP0049; Updated (2006) note: Pfam domain PF04371 Porphyromonas-type peptidyl-arginine deiminase identified within CDS. Product modified to more specific family member based on motif match. Not fully characterised yet,so kept within product function. Functional classification - Misc; peptidyl-arginine deiminase family protein 890256 905241 Cj0949c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptidyl-arginine deiminase family protein YP_002344347.1 889279 R 192222 CDS YP_002344348.1 218562569 905242 complement(890355..890789) 1 NC_002163.1 Original (2000) note: Cj0950c, probable lipoprotein, len: 144 aa; some similarity to HSLJ_ECOLI heat shock protein HSLJ (140 aa), fasta scores; opt: 152 z-score: 202.3 E(): 0.00057, 26.2% identity in 145 aa overlap. 33.3% identity to HP1462 (secreted protein involved in flagellar motility). Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Pfam domain PF03724 Domain of unknown function (306) identified within CDS. Functional classification - Membranes, lipoproteins and porins; lipoprotein 890789 905242 Cj0950c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002344348.1 890355 R 192222 CDS YP_002344349.1 218562570 905244 complement(890799..891473) 1 NC_002163.1 Original (2000) note: Cj0951c, probable MCP-domain signal transduction protein, len: 224 aa; similar to MCP domains in many proteins e.g. CPS_CLOTM sensory transducer protein (557 aa), fasta scores; opt: 270 z-score: 283.0 E(): 1.8e-08, 30.3% identity in 198 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00015 MCPsignal, Methyl-accepting chemotaxis protein (MCP) signaling domain. The ORF continues upstream of this start, and contains BLASTX hits to other MCP proteins,suggesting that this may be a pseudogene, and should be read through from the upstream CDS. The sequence has been checked, and is believed to be correct; Updated (2006) note: No specific characterisation has been carried out yet. kept in product function. Functional classification - Signal transduction; MCP-domain signal transduction protein 891473 905244 Cj0951c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MCP-domain signal transduction protein YP_002344349.1 890799 R 192222 CDS YP_002344350.1 218562571 905245 complement(891663..892382) 1 NC_002163.1 Original (2000) note: Cj0952c, probable membrane protein, len: 239 aa; some simlarity to TR:O66691 (EMBL:AE000686) Aquifex aeolicus AQ_367 (850 aa), fasta scores; opt: 229 z-score: 256.9 E(): 5.2e-07, 26.4% identity in 208 aa overlap. No Hp match. Contains PS00190 Cytochrome c family heme-binding site signature. BLASTX hits to MCP proteins in the C-terminus of this CDS continue into the downstream ORF, suggesting that this may be a pseudogene, and should be read through into the downstream CDS. The sequence has been checked, and is believed to be correct; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Running own Pfam search identified PF00672 HAMP domain. This domain is known as the HAMP domain for histidine kinases, adenylyl cyclases,methyl binding proteins and phosphatases. They are found in bacterial sensor and chemotaxis proteins. The bacterial proteins are usually integral membrane proteins and part of a two-component signal transduction pathway. Product function modified to more specific family member based on motif search results. Functional classification -Membranes, lipoproteins and porins; HAMP containing membrane protein 892382 905245 Cj0952c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 HAMP containing membrane protein YP_002344350.1 891663 R 192222 CDS YP_002344351.1 218562572 905247 complement(892478..894010) 1 NC_002163.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 894010 purH 905247 purH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_002344351.1 892478 R 192222 CDS YP_002344352.1 218562573 905248 complement(894013..894783) 1 NC_002163.1 Original (2000) note: Cj0954c, possible dnaJ-like protein, len: 256 aa; weak similarity to e.g. DJLA_COXBU DNAJ-like protein DJLA (270 aa), fasta scores; opt: 167 z-score: 193.0 E(): 0.0019, 26.9% identity in 201 aa overlap. No Hp match. Contains Pfam match to entry PF00226 DnaJ, DnaJ domain; Updated (2006) note: No specific characterisation with acceptable identity scores carried out yet. kept within product function. Functional classification -Chaperones, chaperonins, heat shock; DnaJ-like protein 894783 905248 Cj0954c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DnaJ-like protein YP_002344352.1 894013 R 192222 CDS YP_002344353.1 218562574 904957 complement(894780..896966) 1 NC_002163.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 896966 purL 904957 purL Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoribosylformylglycinamidine synthase II YP_002344353.1 894780 R 192222 CDS YP_002344354.1 218562575 905249 complement(896977..898305) 1 NC_002163.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 898305 trmE 905249 trmE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tRNA modification GTPase TrmE YP_002344354.1 896977 R 192222 CDS YP_002344355.1 218562576 906015 complement(898298..899116) 1 NC_002163.1 Original (2000) note: Cj0957c, unknown, len: 272 aa; 42.5% identity to HP1451. Functional classification -Conserved hypothetical proteins; hypothetical protein 899116 906015 Cj0957c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344355.1 898298 R 192222 CDS YP_002344356.1 218562577 904358 complement(899120..900706) 1 NC_002163.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 900706 904358 Cj0958c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 inner membrane protein translocase component YidC YP_002344356.1 899120 R 192222 CDS YP_002344357.1 218562578 905228 complement(900703..901044) 1 NC_002163.1 Original (2000) note: Cj0959c, unknown, len: 113 aa; similar to hypothetical proteins from a wide range of organisms, e.g. YIDD_BUCAP (85 aa), fasta scores; opt: 168 z-score: 234.3 E(): 9.5e-06, 32.3% identity in 65 aa overlap, and YIDD_ECOLI (85 aa), fasta scores; opt: 156 z-score: 218.9 E(): 6.8e-05, 31.7% identity in 63 aa overlap. Also similar to TR:Q44066 (EMBL:L36462) Aeromonas hydrophila ALPHA-HEMOLYSIN (85 aa), fasta scores; opt: 156 z-score: 218.9 E(): 6.8e-05, 31.7% identity in 63 aa overlap. 34.2% identity to HP1449; Updated (2006) note: Pfam domain PF01809 Domain of unknown function DUF37 identified within CDS. Conserved added to product function. Functional classification -Conserved hypothetical proteins; hypothetical protein 901044 905228 Cj0959c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344357.1 900703 R 192222 CDS YP_002344358.1 218562579 905252 complement(901041..901367) 1 NC_002163.1 Original (2000) note: Cj0960c, rnpA, probable ribonuclease P protein component, len: 108 aa; similar to e.g. RNPA_BACSU ribonuclease P protein component (EC 3.1.26.5) (116 aa), fasta scores; opt: 195 z-score: 280.1 E(): 2.6e-08, 27.9% identity in 111 aa overlap. 31.9% identity to HP1448. Contains Pfam match to entry PF00825 Ribonuclease_P, Ribonuclease P; Updated (2006) note: Prosite domain PS00648 RIBONUCLEASE_P, Bacterial ribonuclease P protein identified within CDS. Further support given to product function. Characterised in Bacillus subtilis, however,identity score was marginal. not added to product function. Functional classification - RNA synthesis, RNA modification and DNA transcription; PMID:9628904; ribonuclease P protein component 901367 rnpA 905252 rnpA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribonuclease P protein component YP_002344358.1 901041 R 192222 CDS YP_002344359.1 218562580 905034 complement(901364..901498) 1 NC_002163.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 901498 rpmH 905034 rpmH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L34 YP_002344359.1 901364 R 192222 CDS YP_002344360.1 218562581 905253 901629..902108 1 NC_002163.1 Original (2000) note: Cj0962, possible acetyltransferase, len: 159 aa; most similar to eukaryotic acetyltransferases, e.g. TR:P79081 (EMBL:U82218) Schizosaccharomyces pombe acetyltransferase ATS1 (168 aa), fasta scores; opt: 317 z-score: 406.2 E(): 2.5e-15, 34.6% identity in 162 aa overlap, and ATDA_MOUSE diamine acetyltransferase (171 aa), fasta scores; opt: 211 z-score: 274.9 E(): 5.2e-08, 27.4% identity in 168 aa overlap. No Hp match. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification -Misc; acetyltransferase 902108 905253 Cj0962 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetyltransferase YP_002344360.1 901629 D 192222 CDS YP_002344361.1 218562582 905142 902105..902713 1 NC_002163.1 Original (2000) note: Cj0963, unknown, len: 202 aa; similar to hypothetical proteins e.g. TR:O67598 (EMBL:AE000751) Aquifex aeolicus DPLF (195 aa), fasta scores; opt: 234 z-score: 301.4 E(): 1.7e-09, 27.2% identity in 184 aa overlap. 21.4% identity to HP0650. Functional classification - Conserved hypothetical proteins; hypothetical protein 902713 905142 Cj0963 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344361.1 902105 D 192222 CDS YP_002344362.1 218562583 905256 902710..903900 1 NC_002163.1 Original (2000) note: Cj0964, probable periplasmic protein, len: 396 aa; 26.6% identity to HP0781. Contains probable N-terminal signal sequence. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 903900 905256 Cj0964 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344362.1 902710 D 192222 CDS YP_002344363.1 218562584 905257 complement(903892..904266) 1 NC_002163.1 Original (2000) note: Cj0965c, unknown, len: 124 aa; similar to hypothetical proteins e.g. YBGC_ECOLI (134 aa), fasta scores; opt: 235 z-score: 313.7 E(): 3.5e-10,38.1% identity in 113 aa overlap. 40.6% identity to HP0496; Updated (2006) note: Pfam domain PF03061 Thioesterase superfamily and Prosite domain PS01328 4HBCOA_THIOESTERASE, 4-hydroxybenzoyl-CoA thioesterase,active site identified within CDS. Product modified to more specific family member based on motif match. Some characterisation carried out in Escerichia coli with acceptable identity score. kept in product function. Functional classification - Misc; PMID:15808744; acyl-CoA thioester hydrolase 904266 905257 Cj0965c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acyl-CoA thioester hydrolase YP_002344363.1 903892 R 192222 CDS YP_002344364.1 218562585 905258 904409..906697 1 NC_002163.1 Original (2000) note: Cj0967, possible periplasmic protein, len: 762 aa; no Hp match. N- and C- termini are similar to two consecutive genes Cj0735 (37.8% identity in 214 aa overlap) and Cj0736 (42.3% identity in 562 aa overlap). Contains probable N-terminal signal sequence. Note that an ATA initiation codon has been used: this is consistent with the RBS, the similarity to Cj0735, and measures of coding likelyhood based on aa usage. Contains S00639 Eukaryotic thiol (cysteine) proteases histidine active site, PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature, and PS00017 ATP/GTP-binding site motif A (P-loop). Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 906697 905258 Cj0967 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344364.1 904409 D 192222 CDS YP_002344365.1 218562586 905261 907408..907710 1 NC_002163.1 Original (2000) note: Cj0970, unknown, len: 100 aa; no Hp match. Functional classification - Unknown; hypothetical protein 907710 905261 Cj0970 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344365.1 907408 D 192222 CDS YP_002344366.1 218562587 905262 907713..908105 1 NC_002163.1 Original (2000) note: Cj0971, unknown, len: 130 aa; no Hp match. Functional classification - Unknown; hypothetical protein 908105 905262 Cj0971 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344366.1 907713 D 192222 CDS YP_002344367.1 218562588 905263 908107..908430 1 NC_002163.1 Original (2000) note: Cj0972, unknown, len: 107 aa; no Hp match. Functional classification - Unknown; hypothetical protein 908430 905263 Cj0972 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344367.1 908107 D 192222 CDS YP_002344368.1 218562589 905264 908554..908664 1 NC_002163.1 Original (2000) note: Cj0973, unknown, len: 36 aa; no Hp match. Functional classification - Unknown; hypothetical protein 908664 905264 Cj0973 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344368.1 908554 D 192222 CDS YP_002344369.1 218562590 905265 908693..908833 1 NC_002163.1 Original (2000) note: Cj0974, questionable CDS, len 46 aa; no Hp match. Functional classification - Unknown; hypothetical protein 908833 905265 Cj0974 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344369.1 908693 D 192222 CDS YP_002344370.1 218562591 905266 908891..910615 1 NC_002163.1 Original (2000) note: Cj0975, probable outer-membrane protein, len: 584 aa; similar to OM proteins involved in specific protein secretion/activation e.g. HXB1_HAEIN heme-hemopexin utilization protein B precursor (565 aa), fasta scores; opt: 489 z-score: 539.9 E(): 9e-23, 23.9% identity in 570 aa overlap, and HLYB_PROMI hemolysin activator protein precursor (561 aa),fasta scores; opt: 220 z-score: 244.2 E(): 2.7e-06, 21.0% identity in 539 aa overlap. No Hp match. Apparently a complete copy of pseudogene Cj0742; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification -Protein and peptide secretion; outer-membrane protein 910615 905266 Cj0975 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 outer-membrane protein YP_002344370.1 908891 D 192222 CDS YP_002344371.1 218562592 905267 910711..911601 1 NC_002163.1 Original (2000) note: Cj0976, unknown, len: 296 aa; similar to hypothetical proteins e.g. YECP_ECOLI (323 aa),fatsta scores; opt: 649 z-score: 775.1 E(): 0, 35.7% identity in 291 aa overlap. 51.2% identity to HP0419; Updated (2006) note: Prosite domain PS50124 methyltransferase identified within CDS. Product modified to more specific family member based on motif match. kept within product function. Functional classification - Misc; methyltransferase 911601 905267 Cj0976 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methyltransferase YP_002344371.1 910711 D 192222 CDS YP_002344372.1 218562593 905268 911674..912252 1 NC_002163.1 Original (2000) note: Cj0977, unknown, len: 192 aa; 29.2% identity to HP0420; Updated (2006) note: Literature search identified paper linking product function to be involved with invasion of intestinal epithelial cells. Functional classification - Conserved hypothetical proteins; PMID:16369037; hypothetical protein 912252 905268 Cj0977 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344372.1 911674 D 192222 CDS YP_002344373.1 218562594 905269 complement(912253..912426) 1 NC_002163.1 Original (2000) note: Cj0978c, probable lipoprotein, len: 57 aa; no Hp match. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification - Membranes, lipoproteins and porins; lipoprotein 912426 905269 Cj0978c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002344373.1 912253 R 192222 CDS YP_002344374.1 218562595 905270 complement(912435..912962) 1 NC_002163.1 Original (2000) note: Cj0979c, probable secreted nuclease, len: 175 aa; similar to many e.g. NUC_STAHY thermonuclease precursor (EC 3.1.31.1) (169 aa), fasta scores; opt: 206 z-score: 261.7 E(): 2.8e-07, 36.9% identity in 122 aa overlap. No Hp match. Contains possible N-terminal signal sequence and Pfam match to entry PF00565 SNase, Staphylococcal nuclease homologues; Updated (2006) note: Some characterisation work in Staphylococcus spp. kept in product function. Functional classification - Degradation of macromolecules - DNA; PMID:67041918; secreted nuclease 912962 905270 Cj0979c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 secreted nuclease YP_002344374.1 912435 R 192222 CDS YP_002344375.1 218562596 905271 913030..914298 1 NC_002163.1 Original (2000) note: Cj0980, possible peptidase,len: 422 aa; similar to e.g. PEPD_ECOLI aminoacyl-histidine dipeptidase (484 aa), fasta scores; opt: 175 z-score: 206.9 E(): 0.00032, 31.1% identity in 476 aa overlap. No Hp match; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification -Degradation of macromolecules - Proteins, peptides and glycopeptides; PMID:2651887; peptidase 914298 905271 Cj0980 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptidase YP_002344375.1 913030 D 192222 CDS YP_002344376.1 218562597 905272 complement(914281..915528) 1 NC_002163.1 Original (2000) note: Cj0981c, transmembrane transport protein, len: 415 aa; similar to many members of the sugar transporter family e.g. YHJE_ECOLI hypothetical metabolite transport protein I (440 aa), fasta scores; opt: 548 z-score: 610.3 E(): 1.1e-26, 30.4% identity in 418 aa overlap, and PROP_ECOLI proline/betaine transporter (500 aa), fasta scores; opt: 474 z-score: 528.2 E(): 4e-22, 28.0% identity in 421 aa overlap. No Hp ortholog. Contains PS00216 Sugar transport protein; Updated (2006) note: Pfam domains PF07690 Major Facilitator Superfamily and PF00083 Sugar (and other) transporter, were identified within CDS. Twelve probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member based on motif match. Not specifically characterised yet, so kept in product function. Some characterisation work carried out within Campylobacter jejuni. Gene name has been added. Functional classification - Transport/binding proteins - Other; PMID:9395059; MFS transport protein 915528 cjaB 905272 cjaB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MFS transport protein YP_002344376.1 914281 R 192222 CDS YP_002344377.1 218562598 905273 complement(915568..916407) 1 NC_002163.1 Original (2000) note: Cj0982c, probable amino-acid transporter periplasmic solute-binding protein, len: 279 aa; similar to e.g. GLNH_BACST glutamine-binding protein precursor (262 aa), fasta scores; opt: 410 z-score: 484.3 E(): 1.1e-19, 32.4% identity in 253 aa overlap. 98.2% identical to TR:O05414 (EMBL:U93169) C. jejuni OMPH1, and 89.2% identical to TR:P94643 (EMBL:U93169) C. jejuni CjaA. 56.1% identity to HP1172. Contains Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Similar to more than one genus with marginal identity scores. kept within product function. Some characterisation work carried out within Campylobacter jejuni. Gene name has been added. Functional classification - Transport/binding proteins -Other; PMID:9395059; amino-acid transporter periplasmic solute-binding protein 916407 cjaA 905273 cjaA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amino-acid transporter periplasmic solute-binding protein YP_002344377.1 915568 R 192222 CDS YP_002344378.1 218562599 905274 916626..917744 1 NC_002163.1 Original (2000) note: Cj0983, probable lipoprotein,len: 372 aa; 97.0% identical to YHI4_CAMJE. No Hp match. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification - Membranes, lipoproteins and porins; lipoprotein 917744 905274 Cj0983 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002344378.1 916626 D 192222 CDS YP_002344379.1 218562600 905275 917836..918576 1 NC_002163.1 Original (2000) note: Cj0984, unknown, len: 246 aa; 97.2% identical to YHI3_CAMJE. No Hp match. Weak similarity to TR:O66885 (EMBL:AE000700) Aquifex aeolicus AQ_644 (227 aa), fasta scores; opt: 154 z-score: 190.3 E(): 0.0027, 23.6% identity in 212 aa overlap; Updated (2006) note: Pfam domain PF03883 Protein of unknown function (DUF328) identified within CDS. Conserved added to product function. Functional classification -Conserved hypothetical proteins; hypothetical protein 918576 905275 Cj0984 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344379.1 917836 D 192222 CDS YP_002344380.1 218562601 905276 complement(918580..919731) 1 NC_002163.1 Original (2000) note: Cj0985c, hipO, hippurate hydrolase, len: 383 aa; 99.0% identical to HIPO_CAMJE hippurate hydrolase (EC 3.5.1.32), and similar to other hydrolases belinging to the peptidase M40 family (AMA/HIPO/HYUC hydrolase family) e.g. CBPX_SULSO thermostable carboxypeptidase (393 aa), fasta scores; opt: 805 z-score: 949.5 E(): 0, 38.2% identity in 398 aa overlap; Updated (2006) note: Pfam domains PF01546 Peptidase family M20/M25/M40 and PF07687 Peptidase dimerisation domain identified within CDS. Characterised in Campylobacter jejuni, so not added to product function. Functional classification - Misc; PMID:7730270; hippurate hydrolase 919731 hipO 905276 hipO Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hippurate hydrolase YP_002344380.1 918580 R 192222 CDS YP_002344381.1 218562602 905277 complement(919733..919921) 1 NC_002163.1 Original (2000) note: Cj0986c, possible integral membrane protein, len: 62 aa; 98.4% identical to C-terminus of YHI2_CAMJE hypothetical protein (203 aa). No Hp match; Updated (2006) note: Two probable transmembrane helices predicted for Cj0986c by TMHMM2.0. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 919921 905277 Cj0986c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344381.1 919733 R 192222 CDS YP_002344382.1 218562603 905278 complement(919988..920953) 1 NC_002163.1 Original (2000) note: Cj0987c, probable integral membrane protein, len: 321 aa; identical to N- and C-terminus of YHI2_CAMJE hypothetical protein (203 aa),which has a central deletion relative to this CDS. Some similarity to hypothetical membrane proteins e.g. YJHB_ECOLI (405 aa), fasta scores; opt: 239 z-score: 285.2 E(): 1.4e-08, 24.6% identity in 301 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF07690 Major Facilitator Superfamily identified within CDS. Also, nine probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member based on motif match. Not specifically characterised yet, so kept in product function. Functional classification - Transport/binding proteins - Other; MFS transport protein 920953 905278 Cj0987c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MFS transport protein YP_002344382.1 919988 R 192222 CDS YP_002344383.1 218562604 905279 complement(920967..921203) 1 NC_002163.1 Original (2000) note: Cj0988c, questionable CDS,len: 78 aa; 98.3% identical to TR:Q46117 (EMBL:Z36940) C. jejuni hypothetical protein. No Hp match; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Unknown; hypothetical protein 921203 905279 Cj0988c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344383.1 920967 R 192222 CDS YP_002344384.1 218562605 905280 921188..921394 1 NC_002163.1 Original (2000) note: Cj0989, possible membrane protein, len: 68 aa; identical to TR:Q46118 (EMBL:Z36940) C. jejuni hypothetical protein. No Hp match; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; hypothetical protein 921394 905280 Cj0989 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344384.1 921188 D 192222 CDS YP_002344385.1 218562606 905281 complement(921397..922158) 1 NC_002163.1 Original (2000) note: Cj0990c, unknown, len: 253 aa; identical in C-terminus to YHI1_CAMJE C. jejuni hypothetical protein fragment (94 aa). No Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 922158 905281 Cj0990c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344385.1 921397 R 192222 CDS YP_002344386.1 218562607 905282 complement(922155..923420) 1 NC_002163.1 Original (2000) note: Cj0991c, probable oxidoreductase ferredoxin-type electron transport protein,len: 421; weak similarity to e.g. GLPC_ECOLI anaerobic glycerol-3-phosphate dehydrogenase subunit C (396 aa),fasta scores; opt: 280 z-score: 323.3 E(): 1e-10, 23.3% identity in 425 aa overlap, and GLCF_ECOLI glycolate oxidase iron-sulfur subunit (407 aa), fasta scores; opt: 199 z-score: 231.5 E(): 1.4e-05, 22.3% identity in 413 aa overlap. 44.7% identity to HP0666 (annotated as glpC, but there are no homologs of glpA or glpB in Hp or Cj). Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature, and 2x Pfam match to entry PF00037 fer4,4Fe-4S ferredoxins and related iron-sulfur cluster binding domains; Updated (2006) note: Pfam domain PF02754 Cysteine-rich domain identified within CDS. No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification - Energy metabolism - Electron transport; oxidoreductase ferredoxin-type electron transport protein 923420 905282 Cj0991c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 oxidoreductase ferredoxin-type electron transport protein YP_002344386.1 922155 R 192222 CDS YP_002344387.1 218562608 905283 complement(923422..924777) 1 NC_002163.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 924777 hemN 905283 hemN Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 coproporphyrinogen III oxidase YP_002344387.1 923422 R 192222 CDS YP_002344388.1 218562609 905284 complement(924764..925255) 1 NC_002163.1 Original (2000) note: Cj0993c, unknown, len: 163 aa; 30.1% identity to HP0664. Functional classification -Conserved hypothetical proteins; hypothetical protein 925255 905284 Cj0993c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344388.1 924764 R 192222 CDS YP_002344389.1 218562610 905285 complement(925252..926172) 1 NC_002163.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 926172 argF 905285 argF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ornithine carbamoyltransferase YP_002344389.1 925252 R 192222 CDS YP_002344390.1 218562611 905286 complement(926169..927152) 1 NC_002163.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 927152 hemB 905286 hemB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 delta-aminolevulinic acid dehydratase YP_002344390.1 926169 R 192222 CDS YP_002344391.1 218562612 905287 927210..927770 1 NC_002163.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 927770 ribA 905287 ribA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GTP cyclohydrolase II YP_002344391.1 927210 D 192222 CDS YP_002344392.1 218562613 905288 927771..928337 1 NC_002163.1 Original (2000) note: Cj0997, probable gidB homolog. len: 188 aa; similar to gidB proteins from many organisms e.g. GIDB_ECOLI glucose inhibited division protein B (207 aa), fasta scores; opt: 212 z-score: 265.9 E(): 1.6e-07, 24.7% identity in 182 aa overlap. 37.3% identity to HP1063; Updated (2006) note: Pfam domain PF02527 Glucose inhibited division protein identified within CDS. Further support given to product function. Recent characterisation within Escherichia coli has identified GidB containing a methyltransferase fold (PMID:12001236). Thus, product function has now been modified to more specific family member. Functional classification - Misc; PMID:12001236; methyltransferase 928337 905288 Cj0997 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methyltransferase YP_002344392.1 927771 D 192222 CDS YP_002344393.1 218562614 905289 complement(928353..928925) 1 NC_002163.1 Original (2000) note: Cj0998c, probable periplasmic protein, len: 190 aa; 33.9% identity to HP0305. Contains probable N-terminal signal sequence; Updated (2006) note: Paper identified linking protein to glycoprotein. Functional classification -Miscellaneous periplasmic proteins; PMID:12186869; periplasmic protein 928925 905289 Cj0998c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344393.1 928353 R 192222 CDS YP_002344394.1 218562615 905290 complement(929020..930117) 1 NC_002163.1 Original (2000) note: Cj0999c, probable integral membrane protein, len: 365 aa; similar to hypothetical membrane proteins e.g. YEIH_ECOLI (349 aa), fasta scores; opt: 631 z-score: 729.2 E(): 0, 35.7% identity in 347 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03601 Conserved hypothetical protein identified within CDS. Also, eleven probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 930117 905290 Cj0999c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344394.1 929020 R 192222 CDS YP_002344395.1 218562616 905291 930230..931111 1 NC_002163.1 Original (2000) note: Cj1000, probable transcriptional regulator, len: 293 aa; similar to members of the lysR family e.g. YEIE_ECOLI hypothetical transcriptional regulator (293 aa), fasta scores; opt: 332 z-score: 390.5 E(): 1.9e-14, 24.3% identity in 288 aa overlap. No Hp match. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix proteins,lysR family, and probable helix-turn-helix motif at aa 17-38 (Score 1147, +3.09 SD); Updated (2006) note: Pfam domain PF03466 LysR substrate binding domain identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet, so kept in product function. Functional classification - Broad regulatory functions; transcriptional regulator 931111 905291 Cj1000 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcriptional regulator YP_002344395.1 930230 D 192222 CDS YP_002344396.1 218562617 905292 931191..933059 1 NC_002163.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 933059 rpoD 905292 rpoD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 RNA polymerase sigma factor RpoD YP_002344396.1 931191 D 192222 CDS YP_002344397.1 218562618 905293 complement(933075..933587) 1 NC_002163.1 Original (2000) note: Cj1002c, unknown, len: 170 aa; similar to hypothetical proteins e.g. TR:O67234 (EMBL:AE000727) Aquifex aeolicus AQ_1173 (149 aa), fasta scores; opt: 185 z-score: 235.0 E(): 8.6e-06, 34.2% identity in 117 aa overlap. No Hp match; Updated (2006) note: Running own Pfam search allowed identification of Pfam domain PF00300 Phosphoglycerate mutase family. This is an enzyme that catalyses reactions involving the transfer of phospho groups between the 3 carbon atoms of phosphoglycerate. Not specifically characterised, so kept in product function. Functional classification - Energy metabolism -Glycolysis; phosphoglycerate/bisphosphoglycerate mutase 933587 905293 Cj1002c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoglycerate/bisphosphoglycerate mutase YP_002344397.1 933075 R 192222 CDS YP_002344398.1 218562619 905294 complement(933584..934102) 1 NC_002163.1 Original (2000) note: Cj1003c, probable integral membrane protein, len: 172 aa; similar to hypothetical proteins e.g. TR:O59166 (EMBL:AP000006) Pyrococcus horikoshii PH1497 (197 aa), fasta scores; opt: 233 z-score: 292.8 E(): 5.2e-09, 30.8% identity in 172 aa overlap. No Hp ortholog; Updated (2006) note: Pfam domain PF01694 Rhomboid family identified within CDS. Also, five probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. No specific charactersation carried out yet, so kept in product function. Functional classification - Membranes,lipoproteins and porins; integral membrane protein 934102 905294 Cj1003c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344398.1 933584 R 192222 CDS YP_002344399.1 218562620 905295 934201..934617 1 NC_002163.1 Original (2000) note: Cj1004, probable periplasmic protein, len: 138 aa; very weak similarity to TR:P75137 (EMBL:AE000019) Mycoplasma pneumoniae lipoprotein E09_orf129 (129 aa), fasta scores; opt: 110 z-score: 147.3 E(): 0.66, 34.9% identity in 129 aa overlap. No Hp match. Also similar to Cj1626c (38.6% identity in 140 aa overlap); Updated (2006) note: Literature search identified paper giving further clues on product funciton. Functional classification - Miscellaneous periplasmic proteins; PMID:15554967; periplasmic protein 934617 905295 Cj1004 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344399.1 934201 D 192222 CDS YP_002344400.1 218562621 905296 complement(934626..936242) 1 NC_002163.1 Original (2000) note: Cj1005c, probable membrane bound ATPase, len: 538 aa; similar to many members of the AAA family e.g. FTSH_BACSU cell division protein FTSH homolog (EC 3.4.24.-) (637 aa), fasta scores; opt: 901 z-score: 909.6 E(): 0, 36.3% identity in 518 aa overlap. 43.8% identity to HP0286. Also similar to ftsH Cj1116c (36.2% identity in 578 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00674 AAA-protein family signature, and Pfam match to entry PF00004 AAA,ATPases associated with various cellular activities (AAA); Updated (2006) note: Pfam domain PF06480 FtsH Extracellular protein. This domain is found in FtsH family proteins. FtsH is the only membrane-bound ATP-dependent protease universally conserved in prokaryotes. kept within product function. Functional classification -Misc; PMID:8892813, PMID:9244252 and PMID:96132941; membrane bound ATPase 936242 905296 Cj1005c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 membrane bound ATPase YP_002344400.1 934626 R 192222 CDS YP_002344401.1 218562622 905297 complement(936246..937496) 1 NC_002163.1 Original (2000) note: Cj1006c, unknown, len: 416 aa; similar to hypothetical proteins belonging to the UPF0004 family e.g. Y16R_MYCIO (438 aa), fasta scores; opt: 580 z-score: 664.7 E(): 1e-29, 30.5% identity in 413 aa overlap. 50.1% identity to HP0285. Also similar to Cj0458c (28.6% identity in 391 aa overlap) and Cj1454c (28.4% identity in 419 aa overlap). Contains PS01278 Uncharacterized protein family UPF0004 signature and Pfam match to entry PF00919 UPF0004; Updated (2006) note: Pfam domain PF04055 Radical SAM superfamily identified within CDS. TIGRFAM TIGR01579 MiaB-like tRNA modifying enzyme has also been identified. Characterisation papers have also been attached. Product modified based on motif match and supporting literature. Some characterisation in Escherichia coli, however, kept within product function. Functional classification - RNA synthesis, RNA modification and DNA transcription; PMID:10572129, PMID:11882645 and PMID:11313137; MiaB-like tRNA modifying enzyme 937496 905297 Cj1006c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MiaB-like tRNA modifying enzyme YP_002344401.1 936246 R 192222 CDS YP_002344402.1 218562623 905298 complement(937493..939064) 1 NC_002163.1 Original (2000) note: Cj1007c, probable membrane protein, len: 523 aa; similar in C-terminus to hypothetical proteins e.g. Y700_METJA hypothetical protein MJ0700 (324 aa), fasta scores; opt: 281 z-score: 300.2 E(): 2e-09, 29.0% identity in 276 aa overlap. 37.4% identity to HP0284; Updated (2006) note: Pfam domain PF00924 Mechanosensitive ion channel identified within CDS. Also,three probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member based on motif match. No specific characterisation has been carried out yet. kept within product function. Functional classification - Transport/binding proteins - Other; PMID:12446901; mechanosensitive ion channel family protein 939064 905298 Cj1007c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 mechanosensitive ion channel family protein YP_002344402.1 937493 R 192222 CDS YP_002344403.1 218562624 905299 complement(939061..940116) 1 NC_002163.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 940116 aroB 905299 aroB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 3-dehydroquinate synthase YP_002344403.1 939061 R 192222 CDS YP_002344404.1 218562625 905300 complement(940162..941562) 1 NC_002163.1 Original (2000) note: Cj1009c, unknown, len: 466 aa; 29.1% identity to HP0282; Updated (2006) note: Pfam domain PF02080 TrkA-C domain identified within CDS. The TrkA-C domain is typically found next to the -N domain. Currently unknown function. Functional classification - Conserved hypothetical proteins; hypothetical protein 941562 905300 Cj1009c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344404.1 940162 R 192222 CDS YP_002344405.1 218562626 905301 941592..942713 1 NC_002163.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 942713 tgt 905301 tgt Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 queuine tRNA-ribosyltransferase YP_002344405.1 941592 D 192222 CDS YP_002344406.1 218562627 905302 942715..943482 1 NC_002163.1 Original (2000) note: Cj1011, probable membrane protein, len: 255 aa; no Hp match; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Running own Pfam search identified PF01544 CorA-like Mg2+ transporter protein. Product modified to more specific family member based on motif match. No specific characterisation has been carried out yet. kept in product function. Functional classification - Transport/binding proteins - Cations; CorA-like Mg2+ transporter protein 943482 905302 Cj1011 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CorA-like Mg2+ transporter protein YP_002344406.1 942715 D 192222 CDS YP_002344407.1 218562628 905304 complement(943614..944063) 1 NC_002163.1 Original (2000) note: Cj1012c, possible membrane protein, len: 149 aa; no Hp match; Updated (2006) note: One probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; hypothetical protein 944063 905304 Cj1012c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344407.1 943614 R 192222 CDS YP_002344408.1 218562629 905305 complement(944080..947325) 1 NC_002163.1 Original (2000) note: Cj1013c, probable membrane protein, len: 1081 aa; contains three domains; aa 1-90 contains three membrane spanning domains; aa 90-780 is non-membrane, and aa 780-1081 contains ten possible membrane spanning domains. Some similarity in C-teminal membrane domain to eukaryotic proteins e.g. CCSA_CHLRE cytochrome C biogenesis protein CCSA (353 aa), fasta scores; opt: 459 z-score: 515.4 E(): 2.1e-21, 36.0% identity in 267 aa overlap, and to prokaryotic equivalents e.g. CCMF_ECOLI cytochrome C-type biogenesis protein CCMF (647 aa); BLASTP scores; E = 0.20, 24% identity in 293 aa overlap. 39.0% identity to HP0378 (domains 2+3 only); Updated (2006) note: Twelve probable transmembrane helices predicted by TMHMM2.0. Pfam domain PF01578 Cytochrome C assembly protein identified within CDS. Product function modified based on motif match. Some characterisation within Wolinella succinogenes and Escherichia coli, however, identity scores were marginal. kept within product function. Functional classification - Energy metabolism - Electron transport; PMID:10672190, PMID:11069671, PMID:16629661; cytochrome C biogenesis protein 947325 905305 Cj1013c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytochrome C biogenesis protein YP_002344408.1 944080 R 192222 CDS YP_002344409.1 218562630 905306 complement(947343..948038) 1 NC_002163.1 Original (2000) note: Cj1014c, livF, probable branched-chain amino-acid ABC transport system ATP-binding protein, len: 231 aa; similar to e.g. LIVF_ECOLI high-affinity branched-chain amino acid transport ATP-binding protein (237 aa), fasta scores; opt: 686 z-score: 797.6 E(): 0, 46.4% identity in 233 aa overlap. No Hp ortholog. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran; Updated (2006) note: Characterised within Pseudomonas aeruginosa and Escherichia coli with acceptable identity scores. not added to product function. Functional classification - Transport/binding proteins - Amino acids and amines; PMID:2120183, PMID:1429514, PMID:2195019; branched-chain amino-acid ABC transporter ATP-binding protein 948038 livF 905306 livF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 branched-chain amino-acid ABC transporter ATP-binding protein YP_002344409.1 947343 R 192222 CDS YP_002344410.1 218562631 905307 complement(948025..948795) 1 NC_002163.1 Original (2000) note: Cj1015c, livG, probable branched-chain amino-acid ABC transport system ATP-binding protein, len: 256 aa; similar to e.g. LIVG_ECOLI high-affinity branched-chain amino acid transport ATP-binding protein (255 aa), fasta scores; opt: 680 z-score: 800.2 E(): 0, 41.2% identity in 250 aa overlap. No Hp ortholog. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran; Updated (2006) note: Characterised within Pseudomonas aeruginosa and Escherichia coli with acceptable identity scores. not added to product function. Functional classification - Transport/binding proteins - Amino acids and amines; PMID:2120183, PMID:1429514, PMID:2195019; branched-chain amino-acid ABC transporter ATP-binding protein 948795 livG 905307 livG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 branched-chain amino-acid ABC transporter ATP-binding protein YP_002344410.1 948025 R 192222 CDS YP_002344411.1 218562632 905308 complement(948792..949844) 1 NC_002163.1 Original (2000) note: Cj1016c, livM, probable branched-chain amino-acid ABC transport system permease, len: 350 aa; similar to e.g. LIVM_ECOLI high-affinity branched-chain amino acid transport permease (425 aa) fasta scores; opt: 239 z-score: 284.9 E(): 1.4e-08, 31.5% identity in 321 aa overlap. No Hp ortholog; Updated (2006) note: Eight probable transmembrane helices predicted by TMHMM2.0. Pfam domain PF02653 Branched-chain amino acid transport system / permease component. Characterised in Escherichia coli with marginal identity score. Appropriate motifs present. removed from product function. Functional classification - Transport/binding proteins - Amino acids and amines; PMID:2120183, PMID:1429514, PMID:2195019; branched-chain amino-acid ABC transporter permease 949844 livM 905308 livM Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 branched-chain amino-acid ABC transporter permease YP_002344411.1 948792 R 192222 CDS YP_002344412.1 218562633 905309 complement(949844..950740) 1 NC_002163.1 Original (2000) note: Cj1017c, livH, probable branched-chain amino-acid ABC transport system permease, len: 298 aa; similar to e.g. LIVH_ECOLI high-affinity branched-chain amino acid transport permease (308 aa) fasta scores; opt: 538 z-score: 595.2 E(): 7.4e-26, 40.8% identity in 299 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02653 Branched-chain amino acid transport system / permease component identified within CDS. Also, seven probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised in Escherichia coli with marginal identity score. Appropriate motifs present. removed from product function. Functional classification - Transport/binding proteins -Amino acids and amines; PMID:2120183, PMID:1429514, PMID:2195019; branched-chain amino-acid ABC transporter permease 950740 livH 905309 livH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 branched-chain amino-acid ABC transporter permease YP_002344412.1 949844 R 192222 CDS YP_002344413.1 218562634 905310 complement(950759..951868) 1 NC_002163.1 Original (2000) note: Cj1018c, livK, probable branched-chain amino-acid ABC transport system periplasmic binding protein, len: 369 aa; similar to e.g. LIVK_ECOLI LEU/ILE/VAL-binding protein precursor (367 aa), fasta scores; opt: 386 z-score: 436.5 E(): 5.1e-17, 28.3% identity in 272 aa overlap. No Hp match. Highly similar to Cj1019c (62.0% identity in 371 aa overlap); Updated (2006) note: Pfam domain PF01094 Receptor family ligand binding region identified within CDS. Further support given to product function. Paper identified linking protein to glycoprotein (PMID:12186869). Characterised in Escherichia coli with marginal identity score. Appropriate motifs present. removed from product function. Functional classification - Transport/binding proteins - Amino acids and amines; PMID:2649683, PMID:2195019; branched-chain amino-acid ABC transporter periplasmic binding protein 951868 livK 905310 livK Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 branched-chain amino-acid ABC transporter periplasmic binding protein YP_002344413.1 950759 R 192222 CDS YP_002344414.1 218562635 905311 complement(951890..953005) 1 NC_002163.1 Original (2000) note: Cj1019c, livJ, probable branched-chain amino-acid ABC transport system periplasmic binding protein, len: 369 aa; similar to e.g. LIVJ_ECOLI LEU/ILE/VAL-binding protein precursor (367 aa), fasta scores; opt: 419 z-score: 465.8 E(): 1.2e-18, 27.8% identity in 352 aa overlap. No Hp match. Highly similar to Cj1018c (62.0% identity in 371 aa overlap); Updated (2006) note: Pfam domain PF01094 Receptor family ligand binding region identified within CDS. Further support given to producnt fucntion. Characterised in Escherichia coli with marginal identity score. Appropriate motifs present. not added to product function. Functional classification - Transport/binding proteins - Amino acids and amines; PMID:15850393, PMID:2195019; branched-chain amino-acid ABC transporter periplasmic binding protein 953005 livJ 905311 livJ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 branched-chain amino-acid ABC transporter periplasmic binding protein YP_002344414.1 951890 R 192222 CDS YP_002344415.1 218562636 905312 complement(953036..953470) 1 NC_002163.1 Original (2000) note: Cj1020c, probable cytochrome C, len: 144 aa; similar to e.g.C553_DESDN cytochrome C-553 (80 aa), fasta scores; opt: 142 z-score: 184.4 E(): 0.0056, 30.8% identity in 78 aa overlap. Also similar to Cj1153 (27.6% identity in 76 aa overlap). No Hp ortholog. Contains N-terminal signal sequence, PS00190 Cytochrome c family heme-binding site signature, and Pfam match to entry PF00034 cytochrome_c; Updated (2006) note: kept in product function as no specific characterisation has been carried out. Functional classification - Energy metabolism -Electron transport; cytochrome C 953470 905312 Cj1020c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytochrome C YP_002344415.1 953036 R 192222 CDS YP_002344416.1 218562637 905313 complement(953479..953670) 1 NC_002163.1 Original (2000) note: Cj1021c, probable periplasmic protein, len: 63 aa; similar to the N-terminus of C. jejuni major outer membrane protein TR:G2529699 (EMBL:U96452) (MOMP_CAMJE) momp, porA, Cj1259 (424 aa),fasta scores; opt: 110 z-score: 165.3 E(): 0.066, 36.4% identity in 55 aa overlap. No Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF05538 Campylobacter major outer membrane protein identified when running own Pfam search. Some characterisation work within Cj1259, however, alignment was only partial. kept within product function. Psort was also ran with no additional results. Functional classification -Miscellaneous periplasmic proteins; PMID:10992471, PMID:754346, PMID:99163918; periplasmic protein 953670 905313 Cj1021c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344416.1 953479 R 192222 CDS YP_002344417.1 218562638 905314 complement(953723..954229) 1 NC_002163.1 Original (2000) note: Cj1022c, probable integral membrane protein, len: 168 aa; similar to e.g. TR:O66639 (EMBL:AE000682) Aquifex aeolicus AQ_286 (175 aa), fasta scores; opt: 354 z-score: 451.1 E(): 7.9e-18, 34.3% identity in 166 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF07053 Protein of unknown function (DUF1334) identified within CDS. Also,four probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 954229 905314 Cj1022c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344417.1 953723 R 192222 CDS YP_002344418.1 218562639 905315 complement(954238..955269) 1 NC_002163.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 955269 asd 905315 asd Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aspartate-semialdehyde dehydrogenase YP_002344418.1 954238 R 192222 CDS YP_002344419.1 218562640 905316 complement(955269..956570) 1 NC_002163.1 Original (2000) note: Cj1024c, probable signal-transduction regulatory protein, len: 433 aa; similar to e.g. NTRC_PROVU nitrogen regulation protein NR(I) (473 aa), fasta scores; opt: 957 z-score: 1002.5 E(): 0, 38.8% identity in 397 aa overlap, and ATOC_ECOLI acetoacetate metabolism regulatory protein (461 aa), fasta scores; opt: 929 z-score: 973.5 E(): 0, 38.2% identity in 453 aa overlap. 57.1% identity to HP0703. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain, PS00675 and PS00676 Sigma-54 interaction domain ATP-binding regions A and B signatures, and Pfam match to entry PF00158 sigma54, Sigma-54 transcription factors; Updated (2006) note: Characterised within Campylobacter jejuni and Helicobacter pylori. not added to product function. Literature search identified papers linking Cj0793 and Cj1024 to a two-component signal transduction system (FlgS/FlgR) that regulates the fla regulon in Campylobacter jejuni. Similar to that found in Helicobacter pylori. Functional classification - Signal transduction; PMID:11292815, PMID:14617189, PMID:14960570; sigma-54 associated transcriptional activator 956570 flgR 905316 flgR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sigma-54 associated transcriptional activator YP_002344419.1 955269 R 192222 CDS YP_002344420.1 218562641 905317 complement(956627..957076) 1 NC_002163.1 Original (2000) note: Cj1025c, unknown, len: 149 aa; no Hp match. Functional classification - Unknown; hypothetical protein 957076 905317 Cj1025c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344420.1 956627 R 192222 CDS YP_002344421.1 218562642 905318 complement(957052..957567) 1 NC_002163.1 Original (2000) note: Cj1026c, probable lipoprotein, len: 171 aa; 51.0% identity in N-terminus to HP0837 (102 aa). Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Pfam domain PF04164 Protein of unknown function, DUF400 identified within CDS. Literature search identified paper linking product to motility. Functional classification - Membranes, lipoproteins and porins; PMID:14985343; lipoprotein 957567 905318 Cj1026c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002344421.1 957052 R 192222 CDS YP_002344422.1 218562643 905319 complement(957631..960222) 1 NC_002163.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 960222 gyrA 905319 gyrA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA gyrase subunit A YP_002344422.1 957631 R 192222 CDS YP_002344423.1 218562644 905320 complement(960263..960838) 1 NC_002163.1 Original (2000) note: Cj1028c, possible purine/pyrimidine phosphoribosyltransferase, len: 191 aa; weak similarity to e.g. orotate phosphoribosyltransferase domain of PYR5_HUMAN uridine 5'-monophosphate synthase (480 aa), fasta scores; opt: 114 z-score: 145.4 E(): 0.85,25.5% identity in 149 aa overlap. 37.3% identity to HP1473. Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature; Updated (2006) note: Pfam domain PF00156 Phosphoribosyl transferase domain identified within CDS. Further support given to product function. Product kept the same as no specific characterisation has been carried out. Possible was changed to . Literature search identified two papers giving further clues to product function. Functional classification - Miscellaneous nucleoside/nucleotide reactions; PMID:16048946, PMID:12949093; purine/pyrimidine phosphoribosyltransferase 960838 905320 Cj1028c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 purine/pyrimidine phosphoribosyltransferase YP_002344423.1 960263 R 192222 CDS YP_002344424.1 218562645 905321 complement(960835..961479) 1 NC_002163.1 Original (2000) note: Cj1029c, mapA, probable lipoprotein, len: 214 aa; identical to TR:Q46122 (EMBL:X80135) C. jeuni species specific mapA gene (214 aa). No Hp match. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Studied in Campylobacter jejuni. No specific characterisation has been carried out yet. Functional classification - Membranes, lipoproteins and porins; PMID:7790451; liproprotein 961479 mapA 905321 mapA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 liproprotein YP_002344424.1 960835 R 192222 CDS YP_002344425.1 218562646 905322 complement(961556..963352) 1 NC_002163.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 963352 lepA 905322 lepA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GTP-binding protein LepA YP_002344425.1 961556 R 192222 CDS YP_002344426.1 218562647 905323 963479..964753 1 NC_002163.1 Original (2000) note: Cj1031, possible outer membrane component of efflux system, len: 424 aa; similar to members of the PRTF family of secretion proteins e.g. TR:O68960 (EMBL:AF059041) outer membrane pore protein hefA (=HP0605) (477 aa), fasta scores; opt: 238 z-score: 261.5 E(): 2.9e-07, 25.2% identity in 409 aa overlap, and TOLC_SALEN outer membrane protein TOLC precursor (491 aa), fasta scores; opt: 174 z-score: 192.9 E(): 0.0019, 21.5% identity in 437 aa overlap. 24.8% identity to HP0605. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domains x2 PF02321 Outer membrane efflux protein were identified within CDS. Further support given to product function. Characterised in Campylobacter jejuni, so removed from product function. Functional classification - Antibiotic resistance; PMID:16048946, PMID:15793099, PMID:12069964,PMID:15201231, PMID:16303882; multidrug efflux system outer membrane protein 964753 cmeD 905323 cmeD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 multidrug efflux system outer membrane protein YP_002344426.1 963479 D 192222 CDS YP_002344427.1 218562648 905324 964750..965490 1 NC_002163.1 Original (2000) note: Cj1032, possible membrane fusion component of efflux system, len: 246 aa; similar to e.g. TR:O68961 EMBL:AF059041) H. pylori membrane fusion protein hefB (=HP0606) (241 aa), fasta scores; opt: 318 z-score: 369.4 E(): 2.8e-13, 35.5% identity in 248 aa overlap, and part of CZCB_ALCSP cation efflux system protein CZCB (520 aa), fasta scores; opt: 224 z-score: 258.9 E(): 4e-07, 28.6% identity in 213 aa overlap. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain identified by running own Pfam search, PF00529 HlyD family secretion protein. Further support given to product function. Characterised in Campylobacter jejuni, so removed from product function. Functional classification -Antibiotic resistance; PMID:16048946, PMID:15793099, PMID:12069964,PMID:15201231, PMID:16303882; mutlidrug efflux system membrane fusion protein 965490 cmeE 905324 cmeE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 mutlidrug efflux system membrane fusion protein YP_002344427.1 964750 D 192222 CDS YP_002344428.1 218562649 905325 965493..968510 1 NC_002163.1 Original (2000) note: Cj1033, probable integral membrane component of efflux system, len: 1005 aa; similar to members of the ACRB/ACRD/ACRF family e.g. TR:O68962 (EMBL:AF059041) H. pylori RND pump protein hefC (=HP0607) (1026 aa), fasta scores; opt: 1372 z-score: 1439.0 E(): 0, 36.9% identity in 1027 aa overlap, and ACRD_ECOLI acriflavin resistance protein D (1037 aa),fasta scores; opt: 571 z-score: 598.0 E(): 5.2e-26, 25.7% identity in 1033 aa overlap. 37.1% identity to HP0607. Contains PS00017 ATP/GTP-binding site motif A (P-loop),and Pfam match to entry PF00873 ACR_tran, AcrB/AcrD/AcrF family; Updated (2006) note: Twelve probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised in Campylobacter jejuni,so removed from product function. Functional classification - Antibiotic resistance; PMID:16048946, PMID:15793099, PMID:12069964,PMID:15201231, PMID:16303882; multidrug efflux system membrane protein 968510 cmeF 905325 cmeF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 multidrug efflux system membrane protein YP_002344428.1 965493 D 192222 CDS YP_002344429.1 218562650 905326 complement(968534..969340) 1 NC_002163.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 969340 905326 Cj1034c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 adenylosuccinate lyase YP_002344429.1 968534 R 192222 CDS YP_002344430.1 218562651 905327 complement(969341..970060) 1 NC_002163.1 Conjugates Arg from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate; arginyl-tRNA-protein transferase 970060 905327 Cj1035c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 arginyl-tRNA-protein transferase YP_002344430.1 969341 R 192222 CDS YP_002344431.1 218562652 905328 complement(970060..970311) 1 NC_002163.1 Original (2000) note: Cj1036c, possible transcriptional regulator, len: 83 aa; no Hp match. Contains probable helix-turn-helix motif at aa 19-40 (Score 1070, +2.83 SD); Updated (2006) note: Conserved added to product function. Functional classification - Broad regulatory functions; hypothetical protein 970311 905328 Cj1036c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344431.1 970060 R 192222 CDS YP_002344432.1 218562653 905329 complement(970315..971760) 1 NC_002163.1 biotin carboxylase; catalyses the carboxylation of the carrier protein which then transfers the carboxyl group to form malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase subunit A 971760 pycA 905329 pycA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetyl-CoA carboxylase subunit A YP_002344432.1 970315 R 192222 CDS YP_002344433.1 218562654 905330 971900..973063 1 NC_002163.1 Original (2000) note: Cj1038, probable cell division/peptidoglycan biosynthesis protein, len: 387 aa; similar to members of the FTSW/RODA/SPOVE family e.g. RODA_ECOLi rod shape-determining protein RODA (370 aa),fasta scores; opt: 297 z-score: 358.2 E(): 1.2e-12, 27.1% identity in 388 aa overlap, and FTSW_ECOLI cell division protein FTSW (414 aa), fasta scores; opt: 288 z-score: 346.8 E(): 5.1e-12, 28.4% identity in 394 aa overlap. 46.4% identity to HP1560. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein; Updated (2006) note: Ten probable transmembrane helices predicted by TMHMM2.0. Specific characterisation not yet carried out, so kept in product function. Functional classification - Cell division; cell division/peptidoglycan biosynthesis protein 973063 905330 Cj1038 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cell division/peptidoglycan biosynthesis protein YP_002344433.1 971900 D 192222 CDS YP_002344434.1 218562655 905331 973060..974088 1 NC_002163.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 974088 murG 905331 murG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_002344434.1 973060 D 192222 CDS YP_002344435.1 218562656 905332 complement(974059..975222) 1 NC_002163.1 Original (2000) note: Cj1040c, probable transmembrane transport protein, len: 387 aa; simlar to hypothetical membrane proteins e.g. YEAN_ECOLI (393 aa),fasta scores; opt: 641 z-score: 726.5 E(): 0, 31.2% identity in 381 aa overlap, and to CYNX_ECOLI cyanate transport protein CYNX (384 aa), fasta scores; opt: 421 z-score: 480.1 E(): 1.9e-19, 23.9% identity in 368 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF07690 Major Facilitator Superfamily (MFS) protein identified within CDS. Also, Twelve probable transmembrane helices predicted by TMHMM2.0. Specific characterisation has not been carried out yet, so kept in product function. Functional classification - Transport/binding proteins -Other; MFS transport protein 975222 905332 Cj1040c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MFS transport protein YP_002344435.1 974059 R 192222 CDS YP_002344436.1 218562657 905333 complement(975230..976081) 1 NC_002163.1 Original (2000) note: Cj1041c, probable periplasmic ATP/GTP-binding protein, len: 283 aa; no Hp match. Contains probable N-terminal signal sequence and PS00017 ATP/GTP-binding site motif A (P-loop). Functional classification - Miscellaneous periplasmic proteins; periplasmic ATP/GTP-binding protein 976081 905333 Cj1041c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic ATP/GTP-binding protein YP_002344436.1 975230 R 192222 CDS YP_002344437.1 218562658 905334 complement(976144..977034) 1 NC_002163.1 Original (2000) note: Cj1042c, probable transcriptional regulatory protein, len: 296 aa; similar to many members of the ARAC/XYLS family e.g. VIRF_YEREN VIRULENCE regulon transcriptional activator (271 aa),fasta scores; opt: 220 z-score: 270.6 E(): 9e-08, 23.9% identity in 247 aa overlap, and LCRF_YERPE thermoregulatory protein LCRF (271 aa), fasta scores; opt: 219 z-score: 269.4 E(): 1e-07, 23.5% identity in 247 aa overlap. No Hp match. Contains PS00041 Bacterial regulatory proteins, araC family signature, and Pfam match to entry PF00165 HTH_2, Bacterial regulatory helix-turn-helix proteins, araC family; Updated (2006) note: No characterisation with acceptable identity score has been identified, so kept in product function. Literature search identified paper giving further clues to product function. Functional classification - Broad regulatory functions; PMID:15201231; transcriptional regulatory protein 977034 905334 Cj1042c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcriptional regulatory protein YP_002344437.1 976144 R 192222 CDS YP_002344438.1 218562659 905335 complement(977031..977636) 1 NC_002163.1 Original (2000) note: Cj1043c, possible transferase, len: 201 aa; similar to e.g. TENI_BACSU regulatory protein TENI (205 aa), fasta scores; opt: 217 z-score: 277.4 E(): 3.8e-08, 26.3% identity in 171 aa overlap, and THIE_ECOLI thiamin-phosphate pyrophosphorylase (211 aa), fasta scores; opt: 146 z-score: 190.3 E(): 0.0026, 27.9% identity in 154 aa overlap. No Hp ortholog. Also similar to Cj1081c (30.0% identity in 190 aa overlap); Updated (2006) note: Pfam domain PF02581 Thiamine monophosphate synthase/TENI identified by running own Pfam search. Product modified to more specific family member based on motif matches. Specific characterisation with acceptable identity score has not been carried out yet, so kept in product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Thiamine; thiamine-phosphate pyrophosphorylase 977636 905335 Cj1043c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 thiamine-phosphate pyrophosphorylase YP_002344438.1 977031 R 192222 CDS YP_002344439.1 218562660 905336 complement(977626..978771) 1 NC_002163.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH 978771 thiH 905336 thiH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 thiamine biosynthesis protein ThiH YP_002344439.1 977626 R 192222 CDS YP_002344440.1 218562661 905337 complement(978774..979550) 1 NC_002163.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 979550 thiG 905337 thiG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 thiazole synthase YP_002344440.1 978774 R 192222 CDS YP_002344441.1 218562662 905338 complement(979553..980356) 1 NC_002163.1 catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate; thiamine biosynthesis protein ThiF 980356 moeB 905338 moeB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 thiamine biosynthesis protein ThiF YP_002344441.1 979553 R 192222 CDS YP_002344442.1 218562663 905339 complement(980353..980544) 1 NC_002163.1 Original (2000) note: Cj1047c, unknown, len: 63 aa; similar to hypothetical proteins e.g. YC40_ODOSI (73 aa),fasta scores; opt: 131 z-score: 200.4 E(): 0.00072, 37.1% identity in 62 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02597 ThiS family identified within CDS. Product modified to a more specific family member based on motif match. Characterisation has been carried out within Escherichia coli and Bacillus subtilis with marginal simlilarity score. Putativae kept in product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Thiamine; PMID:15489164, PMID:15362849; thiamine biosynthesis protein 980544 thiS 905339 thiS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 thiamine biosynthesis protein YP_002344442.1 980353 R 192222 CDS YP_002344443.1 218562664 905340 complement(980554..981651) 1 NC_002163.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 981651 dapE 905340 dapE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 succinyl-diaminopimelate desuccinylase YP_002344443.1 980554 R 192222 CDS YP_002344444.1 218562665 905341 complement(981655..982254) 1 NC_002163.1 Original (2000) note: Cj1049c, probable integral membrane protein, len: 199 aa; similar to hypothetical membrane proteins belonging to the UPF0056 (MARC) family e.g. YVBG_BACSU (211 aa), fasta scores; opt: 173 z-score: 220.6 E(): 5.4e-05, 32.8% identity in 189 aa overlap. No Hp match; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Also, Pfam domain PF01810 LysE type translocator identified within CDS. Lysine exporter protein is involved in the efflux of excess L-lysine as a control for intracellular levels of L-lysine. Product modified to more specific family member based on motif match. Characterisation has not been specifically carried out, so kept in product function. Functional classification - Transport/binding proteins - Other; LysE family transporter protein 982254 905341 Cj1049c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 LysE family transporter protein YP_002344444.1 981655 R 192222 CDS YP_002344445.1 218562666 905342 complement(982247..982948) 1 NC_002163.1 Original (2000) note: Cj1050c, possible transferase, len: 233 aa; similar to hypothetical proteins and to TR:G2996605 (EMBL:U89687) nicotinic acid mononucleotide:5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (cobB) gene (237 aa), fasta scores; opt: 486 z-score: 586.6 E(): 2.2e-25, 37.7% identity in 207 aa overlap. 42.4% identity to HP1259; Updated (2006) note: Pfam domain PF02146 Sir2 family identified within CDS. These sequences represent the Sir2 family of NAD+-dependent deacetylases. Characterisation has been carried out in Escherichia coli and this matches up with acceptable identity score and appropriate motifs. Product modified to more specific family member. not added to product function. Functional classification - Misc; PMID:10811920, PMID:15019790; NAD-dependent deacetylase 982948 npdA 905342 npdA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NAD-dependent deacetylase YP_002344445.1 982247 R 192222 CDS YP_002344446.1 218562667 905343 complement(982991..987010) 1 NC_002163.1 Original (2000) note: Cj1051c, probable restriction modification enzyme, len: 1339 aa; similar in N-terminal 70% to TR:O85299 (EMBL:AF060542) Haemophilus influenzae biogroup aegyptius HaeIV restriction/modification system (953 aa), fasta scores; opt: 1818 z-score: 1949.8 E(): 0 42.7% identity in 976 aa overlap, and in extreme C-terminus to e.g. T1SA_ECOLI type I restriction enzyme ECOAI specificity protein (589 aa), fasta scores; opt: 393 z-score: 422.5 E(): 3.1e-16, 40.4% identity in 178 aa overlap. No Hp ortholog. Contains PS00092 N-6 Adenine-specific DNA methylases signature; Updated (2006) note: Pfam domains PF01420 x2 Type I restriction modification DNA specificity domain was identified within CDS. Prosite domain PS00290 IG_MHC,Immunoglobulins and major histocompatibility complex proteins signature was also identified within CDS. Further support given to product function. Characterised in Escherichia coli with acceptable identity score. not added to product function. Functional classification -DNA replication, restriction/modification, recombination and repair; PMID:2642743, PMID:12879741, PMID:15699185; restriction modification enzyme 987010 cjeI 905343 cjeI Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 restriction modification enzyme YP_002344446.1 982991 R 192222 CDS YP_002344447.1 218562668 905344 complement(987019..989229) 1 NC_002163.1 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange; recombination and DNA strand exchange inhibitor protein 989229 mutS 905344 mutS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 recombination and DNA strand exchange inhibitor protein YP_002344447.1 987019 R 192222 CDS YP_002344448.1 218562669 905345 complement(989219..989569) 1 NC_002163.1 Original (2000) note: Cj1053c, possible integral membrane protein, len: 116 aa; 25.4% identity to HP0622; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 989569 905345 Cj1053c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344448.1 989219 R 192222 CDS YP_002344449.1 218562670 905346 complement(989562..990860) 1 NC_002163.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 990860 murC 905346 murC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-N-acetylmuramate--L-alanine ligase YP_002344449.1 989562 R 192222 CDS YP_002344450.1 218562671 905347 complement(990924..992897) 1 NC_002163.1 Original (2000) note: Cj1055c, probable integral membrane protein, len: 657 aa; weakly similar to hypothetical proteins, e.g. YQGS_BACSU (638 aa), fasta scores; opt: 197 z-score: 215.2 E(): 0.00011, 22.1% identity in 602 aa overlap. 24.3% identity to HP0578. Contains PS00044 Bacterial regulatory proteins, lysR family signature, though this may be spurious; Updated (2006) note: Pfam domain PF00884 Sulfatase identified within CDS. Sulfatases are enzymes that hydrolyze various sulphate esters. Five probable transmembrane helices predicted by TMHMM2.0. Product function modified to more specific family member based on motif match. No specific characterisation has been carried out yet, so kept in product function. Functional classification - Transport/binding proteins - Other; sulfatase family protein 992897 905347 Cj1055c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sulfatase family protein YP_002344450.1 990924 R 192222 CDS YP_002344451.1 218562672 905348 complement(992909..993685) 1 NC_002163.1 Original (2000) note: Cj1056c, unknown, len: 258 aa; similar to hypothetical proteins e.g. TR:O59829 (EMBL:AL023590) Schizosaccharomyces pombe nitrilase SPCC965.09 (272 aa), fasta scores; opt: 175 z-score: 224.3 E(): 3.4e-05, 25.1% identity in 187 aa overlap. 38.8% identity to HP1481; Updated (2006) note: Prosite domain PS50263 CN_HYDROLASE, Carbon-nitrogen hydrolase domain,Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation yet, so kept within product function. Functional classification - Misc; carbon-nitrogen hydrolase family protein 993685 905348 Cj1056c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 carbon-nitrogen hydrolase family protein YP_002344451.1 992909 R 192222 CDS YP_002344452.1 218562673 905349 complement(993678..993851) 1 NC_002163.1 Original (2000) note: Cj1057c, probable coiled-coil protein, len: 57 aa; 31.5% identity to HP1482. Contains coiled-coil prediction for entire length. Functional classification - Conserved hypothetical proteins; coiled-coil protein 993851 905349 Cj1057c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 coiled-coil protein YP_002344452.1 993678 R 192222 CDS YP_002344453.1 218562674 905350 complement(993848..995305) 1 NC_002163.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 995305 guaB 905350 guaB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 inosine 5'-monophosphate dehydrogenase YP_002344453.1 993848 R 192222 CDS YP_002344454.1 218562675 905351 complement(995315..996676) 1 NC_002163.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 996676 gatA 905351 gatA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_002344454.1 995315 R 192222 CDS YP_002344455.1 218562676 905352 complement(996673..996783) 1 NC_002163.1 Original (2000) note: Cj1060c, small hydrophobic protein, len: 36 aa. No Hp match; Updated (2006) note: One probable transmembrane helix predicted for TMHMM2.0. Also, one signal peptide predicted by SignalP 2.0 HMM. Product function modified to more specific family member. kept within product function. Functional classification - Membranes,lipoproteins and porins; hypothetical protein 996783 905352 Cj1060c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344455.1 996673 R 192222 CDS YP_002344456.1 218562677 905353 complement(996777..999530) 1 NC_002163.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 999530 ileS 905353 ileS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 isoleucyl-tRNA synthetase YP_002344456.1 996777 R 192222 CDS YP_002344457.1 218562678 905354 999629..1000717 1 NC_002163.1 Original (2000) note: Cj1062, unknown, len: 362 aa; C-terminus is similar to hypothetical proteins e.g. YGAD_ENTAG (164 aa), fasta scores; opt: 326 z-score: 399.0 E(): 6.3e-15, 39.9% identity in 153 aa overlap. 33.5% identity in C-terminus to HP0952; Updated (2006) note: Pfam domain PF02464 Competence-damaged protein (CinA) identified within CDS. Product modified to more specific family member based on motif match. Specific characterisation not yet carried out, so kept within product function. Literature search identified paper (PMID:11895937), giving further clues to product function. Functional classification -Pathogenicity; PMID:11895937; CinA-like protein 1000717 905354 Cj1062 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CinA-like protein YP_002344457.1 999629 D 192222 CDS YP_002344458.1 218562679 905355 1000729..1001154 1 NC_002163.1 Original (2000) note: Cj1063, possible acetyltransferase, len: 141 aa; very weak similarity to PHNO_ECOLI PHNO protein (involved in alkylphosphonate uptake) (144 aa), fasta scores; opt: 135 z-score: 184.7 E(): 0.0054, 26.8% identity in 138 aa overlap. No Hp match. Contains Pfam match to entry PF00583 Acetyltransf,Acetyltransferase (GNAT) family; Updated (2006) note: Specific characterisation with acceptable identity score has not been carried out yet, so was kept within product function. Functional classification - Misc; acetyltransferase 1001154 905355 Cj1063 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetyltransferase YP_002344458.1 1000729 D 192222 CDS YP_002344459.1 218562680 905357 1001837..1002442 1 NC_002163.1 Original (2000) note: Cj1066, rdxA, probable nitroreductase, len: 201 aa; similar to TR:O30585 (EMBL:AF012552) H. pylori NADPH-linked flavin nitroreductase RDXA (=HP0954) (210 aa), fasta scores; opt: 261 z-score: 325.6 E(): 7.8e-11, 29.1% identity in 199 aa overlap. 28.3% identity to HP0954. Also similar to upstream pseudogene Cj1064. Contains Pfam match to entry PF00881 Nitroreductase, Nitroreductase family; Updated (2006) note: Some characterisation in Helicobacter pylori. Appropriate motifs present. not added to product function. Functional classification -Misc; nitroreductase 1002442 rdxA 905357 rdxA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 nitroreductase YP_002344459.1 1001837 D 192222 CDS YP_002344460.1 218562681 905358 1002567..1003103 1 NC_002163.1 Original (2000) note: Cj1067, pgsA, probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, len: 201 aa; similar to many e.g. PGSA_ECOLI CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) (181 aa), fasta scores; opt: 320 z-score: 405.9 E(): 2.6e-15, 35.8% identity in 176 aa overlap. 43.9% identity to HP1016. Contains PS00379 CDP-alcohol phosphatidyltransferases signature, and Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. Characterised in Escherichia coli with acceptable identity score, so not added to product function. Functional classification - Synthesis and modification of macromolecules - Phospholipids; PMID:6267013, PMID:9853401; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1003103 pgsA 905358 pgsA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_002344460.1 1002567 D 192222 CDS YP_002344461.1 218562682 905359 1003100..1004206 1 NC_002163.1 Original (2000) note: Cj1068, probable integral membrane protein, len: 368 aa; similar to hypothetical proteins e.g. YAEL_ECOLI (450 aa), fasta scores; opt: 341 z-score: 399.4 E(): 6e-15, 29.0% identity in 445 aa overlap. 39.6% identity to HP0258. Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature, and Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF); Updated (2006) note: Pfam domain PF02163 Peptidase family M50 identified within CDS. Also, four probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet. kept within product function. Functional classification - Degradation of macromolecules - Proteins,peptides and glycopeptides; peptidase M50 family protein 1004206 905359 Cj1068 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptidase M50 family protein YP_002344461.1 1003100 D 192222 CDS YP_002344462.1 218562683 905360 1004199..1005065 1 NC_002163.1 Original (2000) note: Cj1069, unknown, len: 288 aa; similar to hypothetical proteins e.g. YB19_HAEIN HI1119 (292 aa), fasta scores; opt: 428 z-score: 534.0 E(): 1.9e-22, 34.1% identity in 290 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF04393 Protein of unknown function (DUF535) identified within CDS. Conserved added to product function. Functional classification -Conserved hypothetical proteins; hypothetical protein 1005065 905360 Cj1069 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344462.1 1004199 D 192222 CDS YP_002344463.1 218562684 905361 1005152..1005529 1 NC_002163.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 1005529 rpsF 905361 rpsF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S6 YP_002344463.1 1005152 D 192222 CDS YP_002344464.1 218562685 905362 1005538..1006089 1 NC_002163.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1006089 ssb 905362 ssb Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 single-stranded DNA-binding protein YP_002344464.1 1005538 D 192222 CDS YP_002344465.1 218562686 905363 1006100..1006360 1 NC_002163.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 1006360 rpsR 905363 rpsR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S18 YP_002344465.1 1006100 D 192222 CDS YP_002344466.1 218562687 905364 complement(1006421..1008796) 1 NC_002163.1 Original (2000) note: Cj1073c, lon, ATP-dependent protease La, len: 791 aa; 99.7% identical to LON_CAMJE ATP-dependent protease La (EC 3.4.21.53) (791 aa), and similar to many e.g. LON_ECOLI (784 aa), fasta scores; opt: 1394 z-score: 1373.0 E(): 0, 39.9% identity in 782 aa overlap. 55.6% identity to HP1379. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS01046 ATP-dependent serine proteases, lon family, serine active site, and Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities; Updated (2006) note: Characterised in Campylobacter jejuni, so not added to product function. Functional classification - Degradation of macromolecules - Proteins, peptides and glycopeptides; PMID:9742705; ATP-dependent protease La 1008796 lon 905364 lon Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP-dependent protease La YP_002344466.1 1006421 R 192222 CDS YP_002344467.1 218562688 905365 complement(1008813..1009460) 1 NC_002163.1 Original (2000) note: Cj1074c, probable lipoprotein, len: 215 aa; identical to partial TR:O69299 (EMBL:Y17166) C. jejuni (called comL), 34.1% identity to HP1378 (called comL, on basis of weak match to N. gonorrhoeae comL). This gene has no detectable similarity to N.g. comL. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification - Membranes, lipoproteins and porins; lipoprotein 1009460 905365 Cj1074c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002344467.1 1008813 R 192222 CDS YP_002344468.1 218562689 905366 1009621..1010010 1 NC_002163.1 binds to flagellin and appears to stabilize flagellin during flagella assembly; flagellar assembly protein FliW 1010010 905366 Cj1075 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar assembly protein FliW YP_002344468.1 1009621 D 192222 CDS YP_002344469.1 218562690 905367 1010010..1010741 1 NC_002163.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 1010741 proC 905367 proC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 pyrroline-5-carboxylate reductase YP_002344469.1 1010010 D 192222 CDS YP_002344470.1 218562691 905368 1010738..1011040 1 NC_002163.1 Original (2000) note: Cj1077, probable periplasmic protein, len: 100 aa; no Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Some characterisation work carried out within Campylobacter jejuni. Product unchanged, but gene name added. Functional classification - Miscellaneous periplasmic proteins; PMID:12949093; periplasmic protein 1011040 ctsT 905368 ctsT Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344470.1 1010738 D 192222 CDS YP_002344471.1 218562692 905369 1011037..1011699 1 NC_002163.1 Original (2000) note: Cj1078, probable periplasmic protein, len: 220 aa; no Hp match. Contains probable N-terminal signal sequence and PS00572 Glycosyl hydrolases family 1 active site; Updated (2006) note: Some research carried out within Campylobacter jejuni. Product unchanged. Functional classification - Miscellaneous periplasmic proteins; PMID:12949093; periplasmic protein 1011699 905369 Cj1078 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344471.1 1011037 D 192222 CDS YP_002344472.1 218562693 905370 1011696..1012148 1 NC_002163.1 Original (2000) note: Cj1079, probable periplasmic protein, len: 150 aa; no Hp match. Contains probable N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1012148 905370 Cj1079 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344472.1 1011696 D 192222 CDS YP_002344473.1 218562694 905371 complement(1012145..1012774) 1 NC_002163.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 1012774 hemD 905371 hemD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 uroporphyrinogen-III synthase YP_002344473.1 1012145 R 192222 CDS YP_002344474.1 218562695 905372 complement(1012752..1013384) 1 NC_002163.1 Original (2000) note: Cj1081c, thiE, probale thiamin-phosphate pyrophosphorylase, len: 210 aa; similar to many e.g. THIE_BACSU thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) (222 aa), fasta scores; opt: 342 z-score: 426.6 E(): 1.8e-16, 31.6% identity in 206 aa overlap. 38.9% identity to HP0843. Also similar to Cj1043c (29.5% identity in 190 aa overlap); Updated (2006) note: Pfam domain PF02581 Thiamine monophosphate synthase/TENI identified within CDS. Further support given to product function. Characterised in Bacillus subtilis with marginal identity score. Appropriate motifs present. not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Thiamine; PMID:10350464; thiamin-phosphate pyrophosphorylase 1013384 thiE 905372 thiE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 thiamin-phosphate pyrophosphorylase YP_002344474.1 1012752 R 192222 CDS YP_002344475.1 218562696 905373 complement(1013374..1014186) 1 NC_002163.1 Original (2000) note: Cj1082c, thiD, probable phosphomethylpyrimidine kinase, len: 270 aa; similar to many e.g. THID_ECOLI phosphomethylpyrimidine kinase (EC 2.7.4.7) (266 aa), fasta scores; opt: 582 z-score: 703.6 E(): 6.8e-32, 41.0% identity in 261 aa overlap. 43.4% identity to HP0844; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score, so not added to product function. Functional classification -Biosynthesis of cofactors, prosthetic groups and carriers - Thiamine; PMID:10075431; phosphomethylpyrimidine kinase 1014186 thiD 905373 thiD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphomethylpyrimidine kinase YP_002344475.1 1013374 R 192222 CDS YP_002344476.1 218562697 905374 complement(1014183..1014869) 1 NC_002163.1 Original (2000) note: Cj1083c, possible nuclease,len: 228 aa; some similarity with predicted proteins showing similarity to endonucleases e.g. END3_RICPR endonuclease III (EC 4.2.99.18) (212 aa), fasta scores; opt: 147 z-score: 181.9 E(): 0.0078, 25.7% identity in 152 aa overlap. 43.0% identity to HP0602 (annotated as endonuclease III). No detectable similarity to C. jejuni endonuclease III (Cj0595c, equivalent to HP0585); Updated (2006) note: Pfam domain PF00730 HhH-GPD superfamily base excision DNA repair identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet. Possible changed to . Functional classification - DNA replication,restriction/modification, recombination and repair; nuclease 1014869 905374 Cj1083c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 nuclease YP_002344476.1 1014183 R 192222 CDS YP_002344477.1 218562698 905375 complement(1014866..1015627) 1 NC_002163.1 Original (2000) note: Cj1084c, possible ATP/GTP-binding protein, len: 253 aa; similar to part of hypothetical proteins from Synechocystis TR:Q55502 (EMBL:D64006) (436 aa), fasta scores; opt: 586 z-score: 675.2 E(): 2.6e-30, 42.4% identity in 236 aa overlap, and Aquifex aeolicus TR:O66668 (EMBL:AE000684) AQ_336 (196 aa), fasta scores; opt: 383 z-score: 449.2 E(): 1e-17,40.4% identity in 136 aa overlap. No Hp match. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Pfam domain PF05673 Protein of unknown function (DUF815) identified within CDS. No specific characterisation has been carried out yet. kept within product function. Functional classification - Conserved hypothetical proteins; ATP/GTP-binding protein 1015627 905375 Cj1084c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP/GTP-binding protein YP_002344477.1 1014866 R 192222 CDS YP_002344478.1 218562699 905376 complement(1015629..1018565) 1 NC_002163.1 Original (2000) note: Cj1085c, mfd, probable transcription-repair coupling factor, len: 978 aa; similar to many e.g. MFD_ECOLI transcription-repair coupling factor (1148 aa), fasta scores; opt: 1474 z-score: 1608.2 E(): 0, 31.5% identity in 967 aa overlap. 48.3% identity to HP1541. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and Pfam match to entry PF00271 helicase_C,Helicases conserved C-terminal domain; Updated (2006) note: Pfam domains PF03461 TRCF domain, PF00270 DEAD/DEAH box helicase and PF02559 CarD-like/TRCF domain were all identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score. Appropriate motifs present. not added to product funciton. Functional classification - DNA replication,restriction/modification, recombination and repair; PMID:16511235, PMID:12658334, PMID:12086674; transcription-repair coupling factor 1018565 mfd 905376 mfd Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcription-repair coupling factor YP_002344478.1 1015629 R 192222 CDS YP_002344479.1 218562700 905377 complement(1018565..1018960) 1 NC_002163.1 Original (2000) note: Cj1086c, unknown, len: 131 aa; some similarity to hypothetical proteins e.g. TR:O51261 (EMBL:AE001134) Borrelia burgdorferi BB0245 (184 aa), fasta scores; opt: 197 z-score: 255.1 E(): 6.6e-07,30.0% identity in 110 aa overlap. 39.8% identity to HP1542; Updated (2006) note: Pfam domain PF04519 Protein of unknown function, DUF583 are identified within CDS. Prosite domain PS00430 TONB_DEPENDENT_REC_1,TonB-dependent receptor proteins signature 1 was also identified. Functional classification - Conserved hypothetical proteins; hypothetical protein 1018960 905377 Cj1086c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344479.1 1018565 R 192222 CDS YP_002344480.1 218562701 905378 complement(1018897..1019799) 1 NC_002163.1 Original (2000) note: Cj1087c, possible periplasmic protein, len: 300 aa; similar to TR:Q57503 (EMBL:U39068) Vibrio cholerae ToxR activated gene (302 aa), fasta scores; opt: 575 z-score: 642.1 E(): 1.8e-28, 34.4% identity in 305 aa overlap. Also contains a segment of similarity to e.g. LSTP_STASI lysostaphin precursor (493 aa), fasta scores; opt: 262 z-score: 294.5 E(): 4.2e-09,28.8% identity in 208 aa overlap. 36.9% identity to HP1543. Also similar to Cj1215 (40.6% identity in 133 aa overlap), and Cj1235 (40.7% identity in 123 aa overlap). Contains possible N-terminal signal sequence; Updated (2006) note: Pfam domain PF01551 Peptidase family M23 identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification - Degradation of macromolecules - Proteins,peptides and glycopeptides; peptidase 1019799 905378 Cj1087c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptidase YP_002344480.1 1018897 R 192222 CDS YP_002344481.1 218562702 905379 complement(1019786..1020970) 1 NC_002163.1 Original (2000) note: Cj1088c, folC, probable folylpolyglutamate synthase/dihydrofolate synthase, len: 394 aa; similar to many e.g. FOLC_ECOLI folylpolyglutamate synthase (EC 6.3.2.17) / dihydrofolate synthase (EC 6.3.2.12) (422 aa), fasta sores; opt: 315 z-score: 360.4 E(): 8.9e-13, 30.7% identity in 313 aa overlap. 42.7% identity to HP1545. Contains Pfam match to entry PF01225 FPGS, Folylpolyglutamate synthase; Updated (2006) note: Characterised in Escherichia coli with marginal identity score. Appropriate motifs present. not added to product function. Functional classification - Biosynthesis of cofactors,prosthetic groups and carriers - Heme; PMID:3040739, PMID:1939056; folylpolyglutamate synthase/dihydrofolate synthase 1020970 folC 905379 folC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 folylpolyglutamate synthase/dihydrofolate synthase YP_002344481.1 1019786 R 192222 CDS YP_002344482.1 218562703 905380 complement(1020936..1022333) 1 NC_002163.1 Original (2000) note: Cj1089c, unknown, len: 65 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 1022333 905380 Cj1089c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344482.1 1020936 R 192222 CDS YP_002344483.1 218562704 905381 complement(1022317..1022829) 1 NC_002163.1 Original (2000) note: Cj1090c, probable lipoprotein, len: 170 aa; 26.5% identity to HP1546. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification - Membranes,lipoproteins and porins; lipoprotein 1022829 905381 Cj1090c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002344483.1 1022317 R 192222 CDS YP_002344484.1 218562705 905382 complement(1022826..1025255) 1 NC_002163.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 1025255 leuS 905382 leuS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 leucyl-tRNA synthetase YP_002344484.1 1022826 R 192222 CDS YP_002344485.1 218562706 905383 complement(1025265..1026236) 1 NC_002163.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 1026236 secF 905383 secF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 preprotein translocase subunit SecF YP_002344485.1 1025265 R 192222 CDS YP_002344486.1 218562707 905384 complement(1026236..1027816) 1 NC_002163.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 1027816 secD 905384 secD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 preprotein translocase subunit SecD YP_002344486.1 1026236 R 192222 CDS YP_002344487.1 218562708 905385 complement(1027809..1028081) 1 NC_002163.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 1028081 yajC 905385 yajC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 preprotein translocase subunit YajC YP_002344487.1 1027809 R 192222 CDS YP_002344488.1 218562709 905386 1028054..1029379 1 NC_002163.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 1029379 905386 Cj1095 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 apolipoprotein N-acyltransferase YP_002344488.1 1028054 D 192222 CDS YP_002344489.1 218562710 905387 complement(1029616..1030812) 1 NC_002163.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1030812 metK 905387 metK Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 S-adenosylmethionine synthetase YP_002344489.1 1029616 R 192222 CDS YP_002344490.1 218562711 905388 1030953..1032176 1 NC_002163.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 1032176 905388 Cj1097 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 serine/threonine transporter SstT YP_002344490.1 1030953 D 192222 CDS YP_002344491.1 218562712 905389 1032186..1033073 1 NC_002163.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 1033073 pyrB 905389 pyrB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aspartate carbamoyltransferase YP_002344491.1 1032186 D 192222 CDS YP_002344492.1 218562713 905390 1033077..1034798 1 NC_002163.1 Original (2000) note: Cj1099, probable peptidase,len: 573 aa; similar to many members of the peptidase family M3 (zinc metalloprotease) e.g. PEPF_LACLA oligoendopeptidase F (601 aa), fasta scores; opt: 603 z-score: 673.0 E(): 3.4e-30, 25.9% identity in 595 aa overlap. 53.5% identity to HP0470. Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature; Updated (2006) note: Pfam domain PF01432 Peptidase family M3 identified within CDS. Further support given to product function. Specific characterisation has not been carried out yet. not added to product function. Functional classification - Degradation of macromolecules - Proteins, peptides and glycopeptides; peptidase 1034798 905390 Cj1099 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptidase YP_002344492.1 1033077 D 192222 CDS YP_002344493.1 218562714 905391 1034792..1035229 1 NC_002163.1 Original (2000) note: Cj1100, unknown, len: 145 aa; 34.7% identity to HP0469. Functional classification -Conserved hypothetical proteins; hypothetical protein 1035229 905391 Cj1100 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344493.1 1034792 D 192222 CDS YP_002344494.1 218562715 905392 1035226..1037301 1 NC_002163.1 Original (2000) note: Cj1101, probable ATP-dependent DNA helicase, len: 691 aa; similar to many e.g REP_ECOLI ATP-dependent DNA helicase REP (EC 3.6.1.-) (673 aa), fasta scores; opt: 977 z-score: 1067.3 E(): 0,36.9% identity in 640 aa overlap, and UVRD_ECOLI DNA helicase II (EC 3.6.1.-) (720 aa), fasta scores; opt: 1129 z-score: 1232.6 E(): 0, 35.2% identity in 714 aa overlap. 43.7% identity to HP1478. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase; Updated (2006) note: Similar to more than one helicase with acceptable identity scores. not added to product function. Functional classification - DNA replication, restriction/modification, recombination and repair; PMID:9288744, PMID:8419285; ATP-dependent DNA helicase 1037301 905392 Cj1101 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP-dependent DNA helicase YP_002344494.1 1035226 D 192222 CDS YP_002344495.1 218562716 905393 1037298..1038116 1 NC_002163.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1038116 truB 905393 truB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tRNA pseudouridine synthase B YP_002344495.1 1037298 D 192222 CDS YP_002344496.1 218562717 905394 1038110..1038337 1 NC_002163.1 Original (2000) note: Cj1103, csrA, probable carbon storage regulator homolog, len: 75 aa; similar to many e.g. CSRA_ECOLI carbon storage regulator (61 aa), fasta scores; opt: 133 z-score: 202.6 E(): 0.00055, 33.3% identity in 54 aa overlap. 46.7% identity to HP1442; Updated (2006) note: Pfam domain PF02599 Global regulator protein family was identified within CDS. Further support given to product function. Characterised in Escherichia coli with marginal identity score. Homolog designation kept in product function. Functional classification - Broad regulatory functions; PMID:9211896, PMID:8393005; carbon storage regulator 1038337 csrA 905394 csrA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 carbon storage regulator YP_002344496.1 1038110 D 192222 CDS YP_002344497.1 218562718 905395 1038334..1039101 1 NC_002163.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1039101 905395 Cj1104 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_002344497.1 1038334 D 192222 CDS YP_002344498.1 218562719 905396 1039098..1039550 1 NC_002163.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 1039550 smpB 905396 smpB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 SsrA-binding protein YP_002344498.1 1039098 D 192222 CDS YP_002344499.1 218562720 905397 1039561..1040163 1 NC_002163.1 Original (2000) note: Cj1106, possible periplasmic thioredoxin, len: 200 aa; similar to active site region of thioredoxins e.g. THIO_BACSU thioredoxin (103 aa), fasta scores; opt: 112 z-score: 150.6 E(): 0.43, 37.7% identity in 69 aa overlap. Contains probable N-terminal signal sequence. No Hp match. Also similar to Cj1207c (29.4% identity in 201 aa overlap); Updated (2006) note: No specific characterisation with acceptable identity score has been carried out yet,so kept in product function. Functional classification - Energy metabolism - Electron transport; periplasmic thioredoxin 1040163 905397 Cj1106 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic thioredoxin YP_002344499.1 1039561 D 192222 CDS YP_002344500.1 218562721 905398 1040163..1040453 1 NC_002163.1 Original (2000) note: Cj1107, unknown, len: 96 aa; similar to hypothetical proteins e.g. YLJA_ECOLI (also upstream of clpA) (106 aa), fasta scores; opt: 255 z-score: 354.9 E(): 1.8e-12, 44.0% identity in 84 aa overlap. 38.2% identity to HP0032; Updated (2006) note: Pfam domain PF02617 ATP-dependent Clp protease adaptor protein Clps,identified within CDS. Product function modified to more specific family member based on motif match. Characterised in Escherichia coli with acceptable identity score. Appropriate motifs present. not added to product function. Functional classification - Chaperones,chaperonins, heat shock; PMID:12426582, PMID:12235156, PMID:9278503; ATP-dependent Clp protease adaptor protein 1040453 clpS 905398 clpS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP-dependent Clp protease adaptor protein YP_002344500.1 1040163 D 192222 CDS YP_002344501.1 218562722 905399 1040450..1042579 1 NC_002163.1 Original (2000) note: Cj1108, clpA, probable ATP-dependent CLP protease ATP-binding subunit, len: CLPA_ECOLI ATP-dependent CLP protease ATP-binding subunit (758 aa), fasta scores; opt: 1730 z-score: 1803.9 E(): 0,41.2% identity in 748 aa overlap. 41.7% identity to HP0033. Contains 2x PS00017 ATP/GTP-binding site motif A (P-loop), PS00871 Chaperonins clpA/B signature 2, and Pfam match to entry PF00495 clpA_B, Chaperonins clpA /B. Also similar to clpB Cj0509c (36.5% identity in 835 aa overlap); Updated (2006) note: Pfam domains PF02861 Clp amino terminal domain and PF00004 ATPase family associated with various cellular activities (AAA) were identified within CDS. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification - Chaperones, chaperonins, heat shock; PMID:11344323, PMID:11274130; ATP-dependent Clp protease ATP-binding subunit 1042579 clpA 905399 clpA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP-dependent Clp protease ATP-binding subunit YP_002344501.1 1040450 D 192222 CDS YP_002344502.1 218562723 905400 1042554..1043201 1 NC_002163.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 1043201 aat 905400 aat Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 leucyl/phenylalanyl-tRNA--protein transferase YP_002344502.1 1042554 D 192222 CDS YP_002344503.1 218562724 905401 complement(1043223..1044512) 1 NC_002163.1 Original (2000) note: Cj1110c, probable MCP-type signal transduction protein, len: 429 aa; similar to TR:O68016 (EMBL:AF010180) Agrobacterium tumefaciens plasmid pTiC58 MCPA (579 aa), fasta scores; opt: 749 z-score: 785.2 E(): 0, 34.5% identity in 496 aa overlap,and to many other proteins with MCP domains e.g. PILJ_PSEAE PILJ protein (682 aa), fasta scores; opt: 379 z-score: 399.1 E(): 6.3e-15, 26.9% identity in 443 aa overlap, and HLYB_VIBCH hemolysin secretion protein precursor (548 aa), fasta scores; opt: 357 z-score: 377.6 E(): 9.8e-14, 37.0% identity in 173 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00015 MCPsignal,Methyl-accepting chemotaxis protein (MCP) signaling domain; Updated (2006) note: Specific characterisation with acceptable identity score has not been carried out yet, so kept in product function. Functional classification - Signal transduction; MCP-type signal transduction protein 1044512 905401 Cj1110c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MCP-type signal transduction protein YP_002344503.1 1043223 R 192222 CDS YP_002344504.1 218562725 905402 complement(1044593..1045219) 1 NC_002163.1 Original (2000) note: Cj1111c, probable integral membrane protein, len: 208 aa; similar to many hypothetical membrane proteoins, e.g. YVBG_BACSU (211 aa),fasta scores; opt: 324 z-score: 391.8 E(): 1.6e-14, 28.8% identity in 198 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF01914 MarC family integral membrane protein identified within CDS. Also, six probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member based on Pfam match. Specific characterisation has not yet been carried out, so kept within product function. Functional classification - Membranes,lipoproteins and porins; MarC family integral membrane protein 1045219 905402 Cj1111c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MarC family integral membrane protein YP_002344504.1 1044593 R 192222 CDS YP_002344505.1 218562726 905403 complement(1045234..1045593) 1 NC_002163.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; a fusion protein of this enzyme with MsrA and thioredoxin provides protection against oxidative stress in Neisseria gonorrhoeae; methionine sulfoxide reductase B 1045593 905403 Cj1112c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methionine sulfoxide reductase B YP_002344505.1 1045234 R 192222 CDS YP_002344506.1 218562727 905404 1045683..1046480 1 NC_002163.1 Original (2000) note: Cj1113, unknown, len: 265 aa; similar to a hypothetical protein from Haemophilus Y077_HAEIN HI0077 (288 aa), fasta scores; opt: 441 z-score: 521.9 E(): 9.1e-22, 34.5% identity in 275 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF04305 Protein of unknown function (DUF455) identified within CDS. Conserved added to product function. Functional classification -Conserved hypothetical proteins; hypothetical protein 1046480 905404 Cj1113 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344506.1 1045683 D 192222 CDS YP_002344507.1 218562728 905405 complement(1046471..1047199) 1 NC_002163.1 Original (2000) note: Cj1114c, pssA, probable CDP-diacylglycerol--serine O-phosphatidyltransferase, len: 242 aa; similar to the characterised PSS_HELPY CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) (HP1071) (237 aa), fasta scores; opt: 754 z-score: 933.2 E(): 0, 50.9% identity in 226 aa overlap,and to others e.g. PSS_YEAST (275 aa), fasta scores; opt: 287 z-score: 360.8 E(): 8.5e-13, 38.2% identity in 165 aa overlap. Contains PS00379 CDP-alcohol phosphatidyltransferases signature; Updated (2006) note: Characterised within Helicobacter pylori with acceptable identity score. not added to product function. Functional classification - Synthesis and modification of macromolecules - Phospholipids; PMID:9244252, PMID:9260935; CDP-diacylglycerol--serine O-phosphatidyltransferase 1047199 pssA 905405 pssA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CDP-diacylglycerol--serine O-phosphatidyltransferase YP_002344507.1 1046471 R 192222 CDS YP_002344508.1 218562729 905406 complement(1047209..1047826) 1 NC_002163.1 Original (2000) note: Cj1115c, probable membrane protein, len: 205 aa; simimlar to hypothetical proteins e.g. TR:Q50967 (EMBL:U34760) Neisseria gonorrhoeae ORF259 (259 aa), fasta scores; opt: 223 z-score: 281.2 E(): 2.3e-08, 24.6% identity in 191 aa overlap. No Hp match; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Characterised within Escherichia coli and Bacillus subtilis with identity scores marginal identity scores. kept within product function. Functional classification - Misc; PMID:361737, PMID:3042771; phosphatidylserine decarboxylase-related protein 1047826 905406 Cj1115c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphatidylserine decarboxylase-related protein YP_002344508.1 1047209 R 192222 CDS YP_002344509.1 218562730 905407 complement(1047823..1049760) 1 NC_002163.1 Original (2000) note: Cj1116c, ftsH, probable membrane bound zinc metallopeptidase, len: 645 aa; similar to many e.g. FTSH_ECOLI cell division protein FTSH (EC 3.4.24.-) (644 aa), fasta scores; opt: 1598 z-score: 1665.6 E(): 0, 43.3% identity in 609 aa overlap. 67.4% identity to HP1069. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00674 AAA-protein family signature,and Pfam match to entry PF00004 AAA, ATPases associated with various cellular activities (AAA); Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Additional Pfam domains PF06480 FtsH Extracellular and PF01434 Peptidase family M41 were also identified within CDS. Further support given to product function. Characterised in Escherichia coli and others with acceptable identity score, so not added to product function. Functional classification -Degradation of macromolecules - Proteins, peptides and glycopeptides; PMID:8892813, PMID:12037319, PMID:1925026,PMID:8444796; membrane bound zinc metallopeptidase 1049760 ftsH 905407 ftsH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 membrane bound zinc metallopeptidase YP_002344509.1 1047823 R 192222 CDS YP_002344510.1 218562731 905408 complement(1049764..1050609) 1 NC_002163.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 1050609 prmA 905408 prmA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribosomal protein L11 methyltransferase YP_002344510.1 1049764 R 192222 CDS YP_002344511.1 218562732 905409 complement(1050632..1051024) 1 NC_002163.1 Original (2000) note: Cj1118c, cheY, chemotaxis regulatory protein, len: 130 aa; identical to CHEY_CAMJE,and highly similar to e.g. CHEY_ECOLI (128 aa), fasta scores; opt: 376 z-score: 468.7 E(): 8.2e-19, 48.3% identity in 120 aa overlap. 82.8% identity to HP1067. Contains Pfam match to entry PF00072 response_reg,Response regulator receiver domain; Updated (2006) note: Characterised within Campylobacter jejuni. not added to product function. Functional classification - Chemotaxis and mobility; PMID:9076738, PMID:11912013; chemotaxis regulatory protein 1051024 cheY 905409 cheY Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 chemotaxis regulatory protein YP_002344511.1 1050632 R 192222 CDS YP_002344512.1 218562733 905410 complement(1051137..1052030) 1 NC_002163.1 Original (2000) note: Cj1119c, wlaM, pglG, probable integral membrane protein, len: 297 aa; 99.3% identical to TR:O86160 (EMBL:Y11648) C. jejuni 81116 wlaM (297 aa). Also contains short section of similarity to TR:Q56633 (EMBL:L25660) Vibrio cholerae accessory colonization factor (ACFB) (626 aa), fasta scores; opt: 165 z-score: 202.6 E(): 0.00055, 34.0% identity in 103 aa overlap. 37.6% identity to HP0158; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. Characterised in Campylobacter jejuni. The integral membrane protein shows no known role in N-linked glycosylation. Identifed as part of Campylobacter jejuni N-linked glycosylation locus (Cj1119c - Cj1130c). Functional classification - Membranes, lipoproteins and porins; PMID:15752194, PMID:16186480, PMID:16618123,PMID:16547029; integral membrane protein 1052030 pglG 905410 pglG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344512.1 1051137 R 192222 CDS YP_002344513.1 218562734 905411 complement(1052030..1053802) 1 NC_002163.1 Original (2000) note: Cj1120c, wlaL, pglF, possible sugar epimerase/dehydratase, len: 590 aa; 99.5% identical to TR:O86159 (EMBL:Y11648) C. jejuni 81116 wlaL (590 aa),and similar to e.g. CAPD_STAAU Staphylococcus aureus capsular polysaccharide biosynthesis CAPD protein (599 aa), fasta scores; opt: 1051 z-score: 1218.6 E(): 0, 38.4% identity in 614 aa overlap, and TR:O69130 (EMBL:AF064070) Burkholderia pseudomallei epimerase/dehydratase WBII (637 aa), fasta scores; opt: 961 z-score: 1113.9 E(): 0, 36.0% identity in 605 aa overlap. No Hp ortholog. Contains probable integral membrane domain at N-terminus; Updated (2006) note: Pfam domain PF02719 Polysaccharide biosynthesis protein identified within CDS. Characterised in Campylobacter jejuni. Product function modified to more specific family member. This dehydratase forms EDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hexos-4-ulose. Identifed as part of Campylobacter jejuni N-linked glycosylation locus (Cj1119c - Cj1130c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:16421095 PMID:15752194, PMID:16186480,PMID:16618123, PMID:16547029, PMID:16286454; UDP-GlcNAc C4,6 dehydratase 1053802 pglF 905411 pglF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-GlcNAc C4,6 dehydratase YP_002344513.1 1052030 R 192222 CDS YP_002344514.1 218562735 905412 complement(1053804..1054964) 1 NC_002163.1 Original (2000) note: Cj1121c, wlaK, pglE, possible aminotransferase, len: 386 aa; 98.7% identical to TR:O86158 (EMBL:Y11648) C. jejuni 81116 wlaK (386 aa), and similar to e.g. TR:O68392 (EMBL:AF036614) Brucella melitensis perosamine synthetase rfbE (367 aa), fasta scores; opt: 621 z-score: 742.5 E(): 0, 31.5% identity in 375 aa overlap, and TR:P72452 (EMBL:Y00459) Streptomyces griseus aminotransferase strS (378 aa), fasta scores; opt: 426 z-score: 510.6 E(): 3.8e-, 32.2% identity in 264 aa overlap. No Hp ortholog. Contains Pfam match to entry PF01041 DegT_DnrJ_EryC1, DegT/DnrJ/EryC1/StrS family; Updated (2006) note: Characterised in Campylobacter jejuni. Product function modified to more specific family member. This protein acts to form 2,4-diacetamido bacillosamine. Identifed as part of Campylobacter jejuni N-linked glycosylation locus (Cj1119c - Cj1130c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15752194, PMID:16186480, PMID:16618123,PMID:16547029, PMID:16286454, PMID:16690622; UDP-4-keto-6-deoxy-GlcNAc C4 aminotransferase 1054964 pglE 905412 pglE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-4-keto-6-deoxy-GlcNAc C4 aminotransferase YP_002344514.1 1053804 R 192222 CDS YP_002344515.1 218562736 905413 complement(1055060..1055713) 1 NC_002163.1 Original (2000) note: Cj1122c, wlaJ, possible integral membrane protein, len: 217 aa; 99.5% identical to TR:G4100601 (EMBL:AF001497) C. jejuni 11168 orfE (217 aa). Not present in C. jejuni 81116. No Hp match; Updated (2006) note: Three probable transmembrane helices predicted by TMHMM2.0; integral membrane protein 1055713 905413 Cj1122c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344515.1 1055060 R 192222 CDS YP_002344516.1 218562737 905414 complement(1055670..1056257) 1 NC_002163.1 Original (2000) note: Cj1123c, wlaI, pglD, possible transferase, len: 195 aa; 98.0% identical to TR:O86157 (EMBL:Y11648) C. jejuni 81116 wlaI (203 aa), and similar to e.g. TR:Q46674 (EMBL:U05248) E. coli polysialic acid gene cluster region 2 neuD (207 aa), fasta scores; opt: 287 z-score: 358.6 E(): 1.1e-12, 28.6% identity in 203 aa overlap, and in the N-terminus to several acetyltransferases, e.g. LPXD_ECOLI UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase (340 aa), fasta scores; opt: 149 z-score: 188.9 E(): 0.0032, 31.7% identity in 82 aa overlap. No hp match. Also similar to Cj1321 (30.2% identity in 179 aa overlap). Contains 2x Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats); Updated (2006) note: Characterised in Campylobacter jejuni. Product function modified to more specific family member. This protein acts as an acetyltransferase to form 2,4-diacetamido bacillosamine. Identifed as part of Campylobacter jejuni N-linked glycosylation locus (Cj1119c - Cj1130c). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:15752194, PMID:16186480, PMID:16618123,PMID:16547029; acetyltransferase 1056257 pglD 905414 pglD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetyltransferase YP_002344516.1 1055670 R 192222 CDS YP_002344517.1 218562738 905415 complement(1056244..1056846) 1 NC_002163.1 Original (2000) note: Cj1124c, wlaH, pglC, probable galactosyltransferase, len: 200 aa; 99.0% identical to TR:O86156 (EMBL:Y11648) C. jejuni 81116 wlaH (200 aa),96.5% identical to TR:P71124 (EMBL:X91081) C. hyoilei galactosyltransferase RFBP (200 aa), and similar to e.g. RFBP_SALTY UDP-phosphate galactosephosphotransferase (476 aa), fasta scores; opt: 330 z-score: 406.2 E(): 2.5e-15, 38.0% identity in 200 aa overlap. No Hp match. Contains one possible transmembrane domain; Updated (2006) note: Pfam domain PF02397, Bacterial sugar transferase, identified within CDS. Characterised in Campylobacter jejuni. Product function modified to more specific family member. This protein transfers UDP bacillosamine to UndP. not added to product function. Identifed as part of Campylobacter jejuni N-linked glycosylation locus (Cj1119c - Cj1130c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15752194, PMID:16186480, PMID:16618123,PMID:16547029; galactosyltransferase 1056846 pglC 905415 pglC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 galactosyltransferase YP_002344517.1 1056244 R 192222 CDS YP_002344518.1 218562739 905416 complement(1056839..1057969) 1 NC_002163.1 Original (2000) note: Cj1125c, wlaG, pglA, probable galactosyltransferase, len: 376 aa; 98.4% identical to TR:O86155 (EMBL:Y11648) C. jejuni 81116 wlaG (376 aa),82.7% identical to TR:P71123 (EMBL:X91081) C. hyoileigalactosyltransferase RFBF (376 aa), and similar to e.g. TR:O87893 (EMBL:U73942) NEISSERIA MENINGITIDIS GLYCOSYLTRANSFERASE PGLA (376 aa), fasta scores; opt: 549 z-score: 651.7 E(): 5.3e-29, 29.5% identity in 387 aa overlap. No Hp match. Contains Pfam match to entry PF00534 Glycos_transf_1; Updated (2006) note: Pfam domain PF00534, Glycosyl transferase group, identified within CDS. Characterised in Campylobacter jejuni. Product function modified to more specific family member. This protein acts as the GalNAc transferase of the first GalNAc to bacillosamine. not added to product function. Identifed as part of Campylobacter jejuni N-linked glycosylation locus (Cj1119c - Cj1130c). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:15752194, PMID:16186480, PMID:16618123,PMID:16547029; GalNAc transferase 1057969 pglA 905416 pglA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GalNAc transferase YP_002344518.1 1056839 R 192222 CDS YP_002344519.1 218562740 905417 complement(1057979..1060120) 1 NC_002163.1 Original (2000) note: Cj1126c, wlaF, pglB, probable integral membrane protein, possible oligosaccharyl transferase, len: 713 aa; 98.9% identical to TR:O86154 (EMBL:Y11648) C. jejuni 81116 wlaF (713 aa), very weak simlarity to e.g. STT3_HUMAN P46977 oligosaccharyl transferase STT3 subunit homolog (705 aa), blastp scores; E= 6.7e-05, 22% identity in 233 aa overlap and 32% identity in 56 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02516,Oligosaccharyl transferase STT3 subunit, identified within CDS. Characterised in Campylobacter jejuni. Product function modified to more specific family member. This protein acts as the oligosaccharyl transferase to N-glycosylate proteins. not added to product function. Identifed as part of Campylobacter jejuni N-linked glycosylation locus (Cj1119c - Cj1130c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15752194, PMID:16186480, PMID:16618123,PMID:16547029, PMID:16356848, PMID:16641107; oligosaccharide transferase to N-glycosylate proteins 1060120 pglB 905417 pglB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 oligosaccharide transferase to N-glycosylate proteins YP_002344519.1 1057979 R 192222 CDS YP_002344520.1 218562741 905418 complement(1060124..1061221) 1 NC_002163.1 Original (2000) note: Cj1127c, wlaE, probable glycosyltransferase, len: 365 aa; 98.6% identical to TR:O86153 (EMBL:Y11648) C. jejuni 81116 wlaE (365 aa), and similar to e.g. AMSD_ERWAM amylovoran biosynthesis glycosyl transerase AMSD (351 aa), fasta scores; opt: 250 z-score: 309.4 E(): 6.2e-10, 27.1% identity in 351 aa overlap. No Hp match. Contains Pfam match to entry PF00534 Glycos_transf_1; Updated (2006) note: Characterised in Campylobacter jejuni. Product function modified to more specific family member. This protein acts as the GalNAc transferase for the next GalNAc to bacillosamine. not added to product function. Identifed as part of Campylobacter jejuni N-linked glycosylation locus (Cj1119c - Cj1130c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15752194, PMID:16186480, PMID:16618123,PMID:16547029; GalNAc transferase 1061221 pglJ 905418 pglJ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GalNAc transferase YP_002344520.1 1060124 R 192222 CDS YP_002344521.1 218562742 905419 complement(1061209..1062138) 1 NC_002163.1 Original (2000) note: Cj1128c, wlaD, epsI, probable glycosyltransferase, len: 309 aa; 99.7% identical to TR:O86152 (EMBL:Y11648) C. jejuni 81116 wlaD (309 aa),99.7% identical to TR:O52906 (EMBL:AJ000854) C. jejuni 11168 epsI (309 aa), and similar to e.g. TR:O87182 (EMBL:AB017355) Streptococcus agalactiae N-acetylglucosaminyltransferase CPSH (333 aa), fasta scores; opt: 281 z-score: 324.3 E(): 9.1e-11, 23.5% identity in 281 aa overlap. No Hp match. Contains Pfam match to entry PF00535 Glycos_transf_2; Updated (2006) note: Characterised in Campylobacter jejuni. Product function modified to more specific family member. This protein is responsible for adding the glucose branch to the maturing glycan. not added to product function. Identifed as part of Campylobacter jejuni N-linked glycosylation locus (Cj1119c - Cj1130c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15752194, PMID:16186480, PMID:16618123,PMID:16547029; glucosyl transferase 1062138 pglI 905419 pglI Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glucosyl transferase YP_002344521.1 1061209 R 192222 CDS YP_002344522.1 218562743 905420 complement(1062131..1063210) 1 NC_002163.1 Original (2000) note: Cj1129c, wlaC, capM, probable glycosyltransferase, len: 359 aa; identical to TR:O52905 (EMBL:AJ000854) C. jejuni 11168 capM (358 aa), 97.2% identical to TR:O86151 (EMBL:Y11648) C. jejuni 81116 wlaC (358 aa), and similar to e.g. AMSD_ERWAM amylovoran biosynthesis glycosyl transerase (351 aa), fasta scores; opt: 360 z-score: 445.6 E(): 1.6e-17, 27.3% identity in 362 aa overlap. No Hp match. Contains Pfam match to entry PF00534 Glycos_transf_1; Updated (2006) note: Characterised in Campylobacter jejuni. Product function modified to more specific family member. This protein acts as the transferase/polymerase of GalNAc(s) to bacillosamine. not added to product function. Identifed as part of Campylobacter jejuni N-linked glycosylation locus (Cj1119c - Cj1130c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15752194, PMID:16498400, PMID:15184581,PMID:16186480, PMID:16618123, PMID:16547029; GalNAc transferase/polymerase 1063210 pglH 905420 pglH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GalNAc transferase/polymerase YP_002344522.1 1062131 R 192222 CDS YP_002344523.1 218562744 905421 complement(1063207..1064901) 1 NC_002163.1 Original (2000) note: Cj1130c, wlaB, ABC-type transport protein, len: 564 aa; 98.2% identical to TR:O86150 (EMBL:Y11648) C. jejuni 81116 wlaB (564 aa), and similar to e.g. HLY2_ECOLI hemolysin secretion atp-binding protein (707 aa), fasta scores; opt: 655 z-score: 715.2 E(): 1.5e-32, 29.0% identity in 572 aa overlap. Integral membrane domain in N-term contains Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region, ATP-binding domain in C-term contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran, ABC transporters. 38.3% identity to HP1206 (called multidrug resistance protein (hetA)); Updated (2006) note: Characterised in Campylobacter jejuni. Product function modified to more specific family member. This protein flips the glycan across the inner membrane. not added to product function. Identifed as part of Campylobacter jejuni N-linked glycosylation locus (Cj1119c - Cj1130c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15752194, PMID:16547029, PMID:16498400,PMID:16481326; flippase 1064901 pglK 905421 pglK Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flippase YP_002344523.1 1063207 R 192222 CDS YP_002344524.1 218562745 905422 complement(1064895..1065881) 1 NC_002163.1 Original (2000) note: Cj1131c, galE, probable UDP-glucose 4-epimerase, len: 328 aa; 98.2% identical to TR:O86149 (EMBL:Y11648) C. jejuni 81116 galE (328 aa), and similar to e.g. GALE_STRMU UDP-glucose 4-epimerase (EC 5.1.3.2) (333 aa), fasta scores; opt: 887 z-score: 1056.0 E(): 0, 43.7% identity in 327 aa overlap. 50.0% identity to HP0360; Updated (2006) note: Pfam domain PF01370, NAD dependent epimerase/dehydratase family identified within CDS. Characterised within Campylobacter jejuni with recent evidence allowing product function and gene name to be updated. This protein acts as the UDP-GlcNAc/Glc 4-epimerase for the LOS, capsule and N-linked glycan in 11168. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c - Cj1152c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:9720026, PMID:14742567, PMID:10768949,PMID:15509570; UDP-GlcNAc/Glc 4-epimerase 1065881 gne 905422 gne Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-GlcNAc/Glc 4-epimerase YP_002344524.1 1064895 R 192222 CDS YP_002344525.1 218562746 905423 complement(1065939..1066733) 1 NC_002163.1 Original (2000) note: Cj1132c, unknown, len: 264 aa; some similarity to part of DNA polymerases e.g. DPOL_PYRFU DNA polymerase (775 aa), fasta scores; opt: 168 z-score: 197.4 E(): 0.0011, 29.6% identity in 247 aa overlap. Similar in N- and C-termini to sequential Hp CDSs; HP0688 (46.7% identity in 169 aa overlap), and HP0689 (47.4% identity in 95 aa overlap). Contains Pfam match to entry PF00136 DNA_pol_B, DNA polymerase family B; Updated (2006) note: Literature search identified paper giving further clues about product function. Conserved added to product function. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c -Cj1152c). Functional classification - Conserved hypothetical proteins; PMID:15509570; hypothetical protein 1066733 905423 Cj1132c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344525.1 1065939 R 192222 CDS YP_002344526.1 218562747 905424 1066799..1067827 1 NC_002163.1 Original (2000) note: Cj1133, waaC, probable lipopolysaccharide heptosyltransferase, len: 342 aa; 98.2% identical to TR:O87585 (EMBL:AF086705) C. jejuni heptosyltransferase WaaC (342 aa), and similar to e.g. RFAC_ECOLI lipopolysaccharide heptosyltransferase-1 (319 aa), fasta scores; opt: 212 z-score: 252.9 E(): 8.6e-07,26.2% identity in 302 aa overlap. 38.5% identity to HP0279. Contains Pfam match to entry PF01075 Heptosyltranf, Heptosyltransferase; Updated (2006) note: Characterised within Campylobacter jejuni. Product function further updated. not added to product function. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c - Cj1152c). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:16621820, PMID:9831648, PMID:11689567,PMID:15808749, PMID:11083778, PMID:10660542; heptosyltransferase I 1067827 waaC 905424 waaC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 heptosyltransferase I YP_002344526.1 1066799 D 192222 CDS YP_002344527.1 218562748 905425 1067817..1068704 1 NC_002163.1 acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; essential for survival; plays a role in cell responses to environmental changes; lipid A biosynthesis lauroyl acyltransferase 1068704 htrB 905425 htrB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipid A biosynthesis lauroyl acyltransferase YP_002344527.1 1067817 D 192222 CDS YP_002344528.1 218562749 905426 1068701..1070248 1 NC_002163.1 Original (2000) note: Cj1135, probable two-domain glycosyltransferase, len: 515 aa; contains similarities in N- and C-termini to glycosyltransferases e.g. TR:P95373 (EMBL:U58765) Neisseria meningitidis beta 1,4 glucosyltransferase lgtF (252 aa), fatsa scores; opt: 380 z-score: 453.4 E(): 5.9e-18, 30.9% identity in 262 aa overlap, and TR:O85457 Pasteurella multocida glycosyl transferase hyaD (864 aa), fasta scores; opt: 259 z-score: 302.8 E(): 1.4e-09, 28.0% identity in 239 aa overlap. No Hp match. Contains 2x Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; Updated (2006) note: Some characterisation within Neisseria meningitidis,however, identity score was marginal. Appropriate motifs present. Product function modified to more specific family member. This protein is most likely responsible for transferring the two glucose residues to the heptoses. Gilbert (Michel.Gilbert@nrc-cnrc.gc.ca) personal communication. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c - Cj1152c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:11689567, PMID:15808749, PMID:11083778,PMID:10660542; two-domain glucosyltransferase 1070248 905426 Cj1135 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 two-domain glucosyltransferase YP_002344528.1 1068701 D 192222 CDS YP_002344529.1 218562750 905427 1070252..1071424 1 NC_002163.1 Original (2000) note: Cj1136, probable galactosyltransferase, len: 390 aa; similar to e.g. TR:O07340 (EMBL:X85787) Streptococcus pneumoniae SS-1,4-galactosyltransferase CPS14J (318 aa), fasta scores; opt: 309 z-score: 361.4 E(): 7.8e-13, 29.0% identity in 290 aa overlap. No Hp match. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; Updated (2006) note: Pfam domain PF00535 Glycosyl transferase identified within CDS. Product function updated based on motif match. No specific characterisation has been carried out yet, so kept within product function. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c - Cj1152c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:11689567, PMID:15808749, PMID:11083778,PMID:10660542, PMID:16594990; glycosyltransferase 1071424 905427 Cj1136 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glycosyltransferase YP_002344529.1 1070252 D 192222 CDS YP_002344530.1 218562751 905428 complement(1071408..1072403) 1 NC_002163.1 Original (2000) note: Cj1137c, unknown, len: 331 aa; similar to hypothetcal proteins in polysaccharide biosynthesis operons e.g. TR:O86892 (EMBL:AJ006986) Streptococcus pneumoniae CAPP33FI protein (322 aa), fasta scores; opt: 295 z-score: 346.5 E(): 5.3e-12, 26.5% identity in 294 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF05704 Capsular polysaccharide synthesis protein identified within CDS. Product function modified to more specific family member. No specific characterisation has been carried out yet. kept within product function. Gilbert (Michel.Gilbert@nrc-cnrc.gc.ca) personal communication. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c - Cj1152c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:11689567, PMID:14742567, PMID:11083778,PMID:10660542; glycosyltransferase 1072403 905428 Cj1137c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glycosyltransferase YP_002344530.1 1071408 R 192222 CDS YP_002344531.1 218562752 905429 1072461..1073630 1 NC_002163.1 Original (2000) note: Cj1138, probable galactosyltransferase, len: 389 aa; similar to e.g. TR:O07340 (EMBL:X85787) Streptococcus pneumoniae SS-1,4-galactosyltransferase CPS14J (318 aa), fasta scores; opt: 304 z-score: 361.2 E(): 8e-13, 25.8% identity in 383 aa overlap. No Hp match. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; Updated (2006) note: No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Product function modified to more specific family member. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c - Cj1152c). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:16594990, PMID:11083778, PMID:10660542; glycosyltransferase 1073630 905429 Cj1138 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glycosyltransferase YP_002344531.1 1072461 D 192222 CDS YP_002344532.1 218562753 905430 complement(1073619..1074530) 1 NC_002163.1 Original (2000) note: Cj1139c, probable galactosyltransferase, len: 303 aa; similar to e.g. TR:O07340 (EMBL:X85787) Streptococcus pneumoniae SS-1,4-galactosyltransferase CPS14J (318 aa), fasta scores; opt: 309 z-score: 362.2 E(): 7.1e-13, 26.1% identity in 249 aa overlap. No Hp match. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases. Contains C(8-9) polymorphic region at aa 111. C(8), the consensus, allows translation of the full length protein. C(9) would cause a premature truncation after a further 20 aa; Updated (2006) note: Characterised within Campylobacter jejuni. Product function modified to more specific family member. not added to product function. This protein carries out the beta-1,3 galactosyltransferase addition of terminal galactose to LOS. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c - Cj1152c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:10931344, PMID:11083778, PMID:10660542; beta-1,3 galactosyltransferase 1074530 wlaN 905430 wlaN Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 beta-1,3 galactosyltransferase YP_002344532.1 1073619 R 192222 CDS YP_002344533.1 218562754 905431 1074585..1075469 1 NC_002163.1 Original (2000) note: Cj1140, unknown, len: 294 aa; similar to H. influenzae hypothetical protein in lipopolysaccharide biosynthesis gene cluster Y352_HAEIN HI0352 (ORF1) (231 aa), fasta scores; opt: 558 z-score: 672.8 E(): 3.5e-30, 41.5% identity in 229 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF06002 Alpha-2,3-sialyltransferase (CST-I) identified within CDS. Characterisation work carried out within Campylobacter jejuni, so product function modified to new family member. not added to product function. This protein transfers sialic acid from cytidine-5'-monophospho-N-acetyl-neuraminic acid (CMP-NeuAc) to LOS. Gilbert (Michel.Gilbert@nrc-cnrc.gc.ca) personal communication. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c - Cj1152c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:11083778, PMID:11689567, PMID:10660542,PMID:14730352, PMID:16620397; alpha-2,3 sialyltransferase 1075469 cstIII 905431 cstIII Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 alpha-2,3 sialyltransferase YP_002344533.1 1074585 D 192222 CDS YP_002344534.1 218562755 905432 1075450..1076481 1 NC_002163.1 Original (2000) note: Cj1141, neuB1, probable N-acetylneuraminic acid synthetase, len: 343 aa; highly similar to e.g. TR:Q57265 (EMBL:U40740) N-acetylneuraminic acid synthetase (EC 4.1.3.-) (349 aa), fasta scores; opt: 1327 z-score: 1554.1 E(): 0, 59.0% identity in 344 aa overlap. No Hp ortholog. Also similar to Cj1327 (37.1% identity in 329 aa overlap) and Cj1317 (34.4% identity in 340 aa overlap); Updated (2006) note: Pfam domains PF03102 NeuB family and PF01354 Antifreeze-like domain were identified within CDS. Characterisation work carried out within Campylobacter jejuni. Product function further modified to more specific family member. not added to product function. This protein acts in the condensation of N-acetyl-D-mannosamine and phosphoenolpyruvate to N-acetylneuraminic acid. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c -Cj1152c). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:10712693, PMID:11689567, PMID:10660542,PMID:14742567, PMID:16567003; sialic acid synthase 1076481 neuB1 905432 neuB1 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sialic acid synthase YP_002344534.1 1075450 D 192222 CDS YP_002344535.1 218562756 905433 1076478..1077593 1 NC_002163.1 Original (2000) note: Cj1142, neuC1, probable N-acetylglucosamine-6-phosphate 2-epimerase/N-acetylglucosamine-6-phosphatase, len: 371 aa; similar to e.g. TR:Q57141 (EMBL:X78068) Neisseria meningitidis N-acetylglucosamine-6-phosphate 2-epimerase (EC 5.1.3.-) / N-acetylglucosamine-6-phosphatase (EC 3.1.3.-) (377 aa),fatsta scores; opt: 1029 z-score: 1162.4 E(): 0, 44.0% identity in 377 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02350 UDP-N-acetylglucosamine 2-epimerase identified within CDS. Further support given to product function. Product function updated based on characterisation work within Neisseria meningitidis (PMID:15518580). kept within product function. This protein plays a role in sialic acid biosysthesis. Gilbert (Michel.Gilbert@nrc-cnrc.gc.ca) personal communication. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c - Cj1152c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15518580, PMID:11083778, PMID:11689567,PMID:10688204, PMID:11796612; UDP-N-acetylglucosamine 2-epimerase 1077593 neuC1 905433 neuC1 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-N-acetylglucosamine 2-epimerase YP_002344535.1 1076478 D 192222 CDS YP_002344536.1 218562757 905434 1077590..1079200 1 NC_002163.1 Original (2000) note: Cj1143, neuA1, probable acylneuraminate cytidylyltransferase (CMP-N-acetylneuraminic acid synthetase), len: 536 aa; N-terminus is similar to HP0217 (49.1% identity in 279 aa overlap), C-traminus is similar to NEUA_NEIME acylneuraminate cytidylyltransferase (EC 2.7.7.43) (228 aa), fasta scores; opt: 471 z-score: 550.3 E(): 2.3e-23,39.4% identity in 221 aa overlap, and to Cj1311 (31.6% identity in 215 aa overlap) and Cj1331 (34.7% identity in 219 aa overlap); Updated (2006) note: Pfam domains PF06306 Beta-1,4-N-acetylgalactosaminylt transferase and PF02348 Cytidylyltransferase were identified within CDS. Further support given to product function. Product function modified to more specific family member based on recent characterisation papers. This protein converts N-acetylneuraminic acid to CMP N-acetylneuraminic acid. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c - Cj1152c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15808749, PMID:11083778, PMID:16481326,PMID:12044670, PMID:10660542, PMID:11796612; bifunctional beta-1,4-N-acetylgalactosaminyltransferase/CMP-Neu5Ac synthase 1079200 neuA1 905434 neuA1 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bifunctional beta-1,4-N-acetylgalactosaminyltransferase/CMP-Neu5Ac synthase YP_002344536.1 1077590 D 192222 CDS YP_002344537.1 218562758 905436 complement(join(1079195..1079743,1079745..1080041)) 1 NC_002163.1 Original (2000) note: Cj1144c, unknown, len: 197 aa; no Hp match. Contains C(8-9) polymorphism at aa 15; C(8), the consnsus gives this CDS; C(9) would cause truncation after 4 aa, although a Met at aa 23 would allow translation to re-initiate. C(7) or C(10), although not seen in shotgun, would allow translation from upstream CDS Cj1145c; Original (2000) note: Cj1145c, unknown, len: 105 aa; no Hp match. Contains C(8-9) polymorphism at aa 99; C(8), the consnsus gives this CDS; C(9) would cause truncation after4 aa; C(7) or C(10), although not seen in shotgun, would allow translation into downstream CDS Cj1144c; Updated (2006) note: Coding sequences have been merged to reflect the complete amino acid sequence for this gene regardless of phase. Previous annotation gave Cj1144c and Cj1145c as seperate CDS. Merging of these CDSs has lead to loss of the downstream CDS. Functional classification - Unknown; hypothetical protein 1080041 905436 Cj1145c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344537.1 1079195 R 192222 CDS YP_002344538.1 218562759 905437 complement(1080025..1080849) 1 NC_002163.1 Original (2000) note: Cj1146c, waaV, possible glucosyltransferase, len: 274 aa; similar to e.g. TR:O87182 (EMBL:AB017355) Streptococcus agalactiae N-acetylglucosaminyltransferase CPSH (333 aa), fasta scores; opt: 339 z-score: 402.4 E(): 4.1e-15, 31.4% identity in 274 aa overlap. No Hp match. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; Updated (2006) note: Some characterisation within Escherichia coli, however, identity score was marginal. kept within product function. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c - Cj1152c). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:9792656; glucosyltransferase 1080849 waaV 905437 waaV Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glucosyltransferase YP_002344538.1 1080025 R 192222 CDS YP_002344539.1 218562760 905438 1080908..1081867 1 NC_002163.1 Original (2000) note: Cj1148, waaF, probable ADP-heptose--LPS heptosyltransferase, len: 319 aa; similar to e.g. TR:Q51063 (EMBL:Z37141) Neisseria gonorrhoeae ADP-heptose:LPS heptosyltransferase II (336 aa), fasta scores; opt: 384 z-score: 447.0 E(): 1.3e-17, 29.7% identity in 333 aa overlap, and RFAF_ECOLI ADP-heptose--LPS heptosyltransferase II (348 aa), fasta scores; opt: 292 z-score: 341.5 E(): 1e-11, 24.1% identity in 348 aa overlap. 37.6% identity to HP1191. Also similar to Cj1133 (24.8% identity in 351 aa overlap). Contains Pfam match to entry PF01075 Heptosyltranf,Heptosyltransferase; Updated (2006) note: Pfam domain now modified to Glycosyltransferase family 9 (heptosyltransferase). Characterisation work carried out within Campylobacter jejuni, so not added to product function. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c - Cj1152c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:9446588, PMID:11054112, PMID:11914340; heptosyltransferase II 1081867 waaF 905438 waaF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 heptosyltransferase II YP_002344539.1 1080908 D 192222 CDS YP_002344540.1 218562761 905439 complement(1081848..1082408) 1 NC_002163.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 1082408 gmhA 905439 gmhA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoheptose isomerase YP_002344540.1 1081848 R 192222 CDS YP_002344541.1 218562762 905440 complement(1082405..1083790) 1 NC_002163.1 Original (2000) note: Cj1150c, waaE, possible ADP-heptose synthase, len: 461 aa; similar to TR:Q48046 (EMBL:U17642) Haemophilus influenzae ADP-heptose synthase (342 aa), fasta scores; opt: 687 z-score: 784.6 E(): 0,40.8% identity in 306 aa overlap. Similar in N-term to RBSK_BACSU ribokinase (286 aa), fasta scores; opt: 204 z-score: 238.0 E(): 5.9e-06, 28.1% identity in 295 aa overlap, and in C-term to TAGD_BACSU glycerol-3-phosphate cytidylyltransferase (129 aa), fasta scores; opt: 208 z-score: 247.5 E(): 1.7e-06, 34.9% identity in 129 aa overlap. 50.8% identity to HP0858. Contains 2x Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase; Updated (2006) note: Pfam domain PF01467 Cytidylyltransferase identified within CDS. Characterised within Escherichia coli with acceptable identity score. Product function updated to more specific family member. Gene name was formerly designated as waaE. not added to product function. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c -Cj1152c). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:10629197, PMID:11751812, PMID:16030223,PMID:11751812, PMID:12101286; D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase 1083790 hldE 905440 hldE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase YP_002344541.1 1082405 R 192222 CDS YP_002344542.1 218562763 905441 complement(1083783..1084736) 1 NC_002163.1 Original (2000) note: Cj1151c, waaD, probable ADP-L-glycero-D-manno-heptose-6-epimerase, len: 317 aa; similar to e.g. RFAD_ECOLI ADP-L-glycero-D-manno-heptose-6-epimerase (EC 5.1.3.20) (310 aa), fasta scores; opt: 533 z-score: 600.5 E(): 3.8e-26. 32.9% identity in 319 aa overlap. 48.3% identity to HP0859; Updated (2006) note: Pfam domain PF01370 NAD dependent epimerase/dehydratase family identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score. Product function has been updated. Gene name was formerly waaD. not added to product function. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c - Cj1152c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:10896473, PMID:11751812, PMID:16481326,PMID:12101286; ADP-glyceromanno-heptose 6-epimerase 1084736 hldD 905441 hldD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ADP-glyceromanno-heptose 6-epimerase YP_002344542.1 1083783 R 192222 CDS YP_002344543.1 218562764 905442 complement(1084737..1085297) 1 NC_002163.1 Original (2000) note: Cj1152c, possible phosphatase, len: 186 aa; similar to hypothetical proteins e.g. YAED_ECOLI (191 aa), fasta scores; opt: 295 z-score: 372.3 E(): 1.9e-13, 45.1% identity in 153 aa overlap. 46.2% identity to HP0860. Some similarity to N-terminal histidinol-phosphatase domain of hisB proteins e.g. HIS7_ECOLI imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase (355 aa), fasta scores; opt: 266 z-score: 332.8 E(): 3.1e-11, 30.8% identity in 146 aa overlap; Updated (2006) note: Pfam domain PF00702 haloacid dehalogenase-like hydrolase identified within CDS. Characterisation work carried out within Escherichia coli and Campylobacter jejuni with acceptable identity scores. GmhB is required for the formation of ADP-D-beta-D-heptose. Product function modified to more specific family member. not added to product function. Identifed as part of Campylobacter jejuni lipooligosaccharide locus (Cj1131c - Cj1152c). Functional classification - Misc; PMID:11751812, PMID:12101286; D,D-heptose 1,7-bisphosphate phosphatase 1085297 gmhB 905442 gmhB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 D,D-heptose 1,7-bisphosphate phosphatase YP_002344543.1 1084737 R 192222 CDS YP_002344544.1 218562765 905443 1085379..1085681 1 NC_002163.1 Original (2000) note: Cj1153, probable periplasmic cytochrome C, len: 100 aa; similar to many e.g. 553_DESVH cytochrome C-553 precursor (103 aa), fasta scores; opt: 187 z-score: 243.8 E(): 2.8e-06, 34.6% identity in 107 aa overlap. 31.0% identity to HP1227. Contains PS00190 Cytochrome c family heme-binding site signature, and Pfam match to entry PF00034 cytochrome_c; Updated (2006) note: Characterisation work has been carried out in Helicobacter pylori, however, identity searches were marginal. kept in product function. Functional classification - Energy metabolism - Electron transport; PMID:10965034; periplasmic cytochrome C 1085681 905443 Cj1153 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic cytochrome C YP_002344544.1 1085379 D 192222 CDS YP_002344545.1 218562766 905444 complement(1085704..1085910) 1 NC_002163.1 Original (2000) note: Cj1154c, small hydrophobic protein, len: 68 aa; 38.7% identity to HP1163; Updated (2006) note: Pfam domain PF03597 Cytochrome oxidase maturation protein cbb3-type identified within CDS. Also, one probable transmembrane helix predicted by TMHMM2.0. Product modified to more specific family member based on motif match. Specific characterisation has not been carried out yet, so kept within product function. Functional classification - Protein translation and modification; cytochrome oxidase maturation protein cbb3-type 1085910 905444 Cj1154c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytochrome oxidase maturation protein cbb3-type YP_002344545.1 1085704 R 192222 CDS YP_002344546.1 218562767 905445 complement(1085907..1088264) 1 NC_002163.1 Original (2000) note: Cj1155c, probable cation-transporting ATPase, len: 785 aa; similar to members of the E1-E2 ATPase family e.g. ATCU_ECOLI probable copper-transporting ATPase (834 aa), fasta scores; opt: 708 z-score: 767.6 E(): 0, 28.9% identity in 830 aa overlap. 36.5% identity to HP1503. Contains 2x Pfam match to entry PF00122 E1-E2_ATPase; Updated (2006) note: Pfam domains PF00702 haloacid dehalogenase-like hydrolase and PF00403 Heavy-metal-associated domain were identified within CDS. Eight probable transmembrane helices predicted by TMHMM2.0. Some characterisation within Escherichia coli and others with marginal identity scores. kept within product function. Functional classification -Transport/binding proteins - Cations; cation-transporting ATPase 1088264 905445 Cj1155c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cation-transporting ATPase YP_002344546.1 1085907 R 192222 CDS YP_002344547.1 218562768 905446 1088373..1089671 1 NC_002163.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 1089671 rho 905446 rho Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcription termination factor Rho YP_002344547.1 1088373 D 192222 CDS YP_002344548.1 218562769 905447 1089675..1091204 1 NC_002163.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 1091204 dnaX 905447 dnaX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA polymerase III subunits gamma and tau YP_002344548.1 1089675 D 192222 CDS YP_002344549.1 218562770 905448 complement(1091201..1091428) 1 NC_002163.1 Original (2000) note: Cj1158c, small hydrophobic protein, len: 75 aa; no Hp match; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 1091428 905448 Cj1158c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344549.1 1091201 R 192222 CDS YP_002344550.1 218562771 905449 complement(1091407..1091529) 1 NC_002163.1 Original (2000) note: Cj1159c, small hydrophobic protein, len: 40 aa; no Hp match; Updated (2006) note: One probable transmembrane helices predicted by TMHMM2.0. Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 1091529 905449 Cj1159c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344550.1 1091407 R 192222 CDS YP_002344551.1 218562772 905450 complement(1091544..1091723) 1 NC_002163.1 Original (2000) note: Cj1160c, small hydrophobic protein, len: 59 aa; no Hp match; Updated (2006) note: One probable transmembrane helix predicted for TMHMM2.0. Also, one signal peptide predicted by SignalP 2.0 HMM. Product function modified to more specific family member. kept within product function. Functional classification - Membranes,lipoproteins and porins; hypothetical protein 1091723 905450 Cj1160c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344551.1 1091544 R 192222 CDS YP_002344552.1 218562773 905451 complement(1091795..1093894) 1 NC_002163.1 Original (2000) note: Cj1161c, probable cation-transporting ATPase, len: 699 aa; similar to members of the E1-E2 ATPase family e.g. COPA_HELFE copper-transporting ATPase (732 aa), fasta scores; opt: 1106 z-score: 1124.4 E(): 0, 32.8% identity in 729 aa overlap. 33.2% identity to HP1072. Contains Pfam match to entry PF00403 HMA, Heavy-metal-associated domain containing proteins, 2x Pfam match to entry PF00122 E1-E2_ATPase, and PS00154 E1-E2 ATPases phosphorylation site; Updated (2006) note: Characterisation in more than one bacteria with marginal identity scores. kept within product function. Functional classification -Transport/binding proteins - Cations; PMID:9440521; cation-transporting ATPase 1093894 905451 Cj1161c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cation-transporting ATPase YP_002344552.1 1091795 R 192222 CDS YP_002344553.1 218562774 905452 complement(1093894..1094088) 1 NC_002163.1 Original (2000) note: Cj1162c, unknown, len: 64 aa; no Hp match; Updated (2006) note: Prosite domain PS50846 HMA_2,Heavy metal transport/detoxification protein within CDS. Product modified to more specific family member based on motif match. No specific characterisation carried out yet,so kept within product function. Functional classification - Conserved hypothetical proteins; heavy-metal-associated domain protein 1094088 905452 Cj1162c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 heavy-metal-associated domain protein YP_002344553.1 1093894 R 192222 CDS YP_002344554.1 218562775 905453 complement(1094078..1095028) 1 NC_002163.1 Original (2000) note: Cj1163c, possible cation transport protein, len: 316 aa; similar to e.g. CZCD_ALCEU cobalt-zinc-cadmium resistance protein CZCD (316 aa),fasta scores; opt: 609 z-score: 699.8 E(): 1.1e-31, 36.2% identity in 287 aa overlap. No Hp match. Contains His-rich regin at N-terminus. Also similar to Cj0948c (25.7% identity in 280 aa overlap); Updated (2006) note: Pfam domain PF01545 Cation efflux family domain identified within CDS. Also, six probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterisation has been carried out in more than one bacteria with marginal identity scores. kept within product function. Functional classification -Transport/binding proteins - Cations; PMID:9044283; cation transport protein 1095028 905453 Cj1163c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cation transport protein YP_002344554.1 1094078 R 192222 CDS YP_002344555.1 218562776 905454 complement(1095104..1095367) 1 NC_002163.1 Original (2000) note: Cj1164c, unknown, len: 87 aa; no Hp match. Contains two Cys pairs; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 1095367 905454 Cj1164c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344555.1 1095104 R 192222 CDS YP_002344556.1 218562777 905455 complement(1095437..1095931) 1 NC_002163.1 Original (2000) note: Cj1165c, probable integral membrane protein, len: 164 aa; some similarity to hypothetical proteins e.g. YJJB_ECOLI (128 aa), fasta scores; opt: 171 z-score: 229.8 E(): 1.7e-05, 29.2% identity in 106 aa overlap. No Hp match. Contains one Cys pair; Updated (2006) note: Five probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 1095931 905455 Cj1165c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344556.1 1095437 R 192222 CDS YP_002344557.1 218562778 905456 complement(1095928..1096704) 1 NC_002163.1 Original (2000) note: Cj1166c, probable integral membrane protein, len: 258 aa; some similarity to hypothetical proteins e.g. YJJP_ECOLI (277 aa), fasta scores; opt: 292 z-score: 367.7 E(): 3.5e-13, 25.8% identity in 236 aa overlap. No Hp match. Contains one Cys pair; Updated (2006) note: Pfam domain PF06738 Protein of unknown function (DUF1212) identified within CDS. Five probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 1096704 905456 Cj1166c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344557.1 1095928 R 192222 CDS YP_002344558.1 218562779 905457 1096771..1097697 1 NC_002163.1 Original (2000) note: Cj1167, ldh, probable L-lactate dehydrogenase, len: LDH_LACLA L-lactate dehydrogenase (EC 1.1.1.27) (324 aa), fasta scores; opt: 579 z-score: 683.7 E(): 8.8e-31, 33.7% identity in 306 aa overlap. No Hp match. Also similar to Cj0532 mdh (25.4% identity in 311 aa overlap). Contains; Updated (2006) note: Pfam domains PF00056 lactate/malate dehydrogenase, NAD binding domain and PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal were identified within CDS. Also, Prosite PS00064 L_LDH, L-lactate dehydrogenase active site was identified within CDS. Further support given to product function. Characterisation work has been carried out in Lactococcus lactis with marginal identity score. Appropriate motifs present. removed from product function. Functional classification - Energy metabolism -Respiration - Aerobic; PMID:8081494, PMID:15644899; L-lactate dehydrogenase 1097697 ldh 905457 ldh Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 L-lactate dehydrogenase YP_002344558.1 1096771 D 192222 CDS YP_002344559.1 218562780 905458 complement(1097694..1098296) 1 NC_002163.1 Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0; Original (2000) note: Cj1168c, probable integral membrane protein (dedA homolog), len: 200 aa; similar to many members of the dedA family e.g. APL_LACLA alkaline phosphatase like protein (242 aa), fasta scores; opt: 424 z-score: 531.1 E(): 2.8e-22, 37.5% identity in 208 aa overlap, and DEDA_ECOLI DEDA protein (219 aa), fasta scores; opt: 240 z-score: 306.1 E(): 9.5e-10, 24.7% identity in 190 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00597 DedA. Also similar to Cj1210 (24.5% identity in 200 aa overlap). Functional classification -Membranes, lipoproteins and porins; integral membrane protein 1098296 905458 Cj1168c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344559.1 1097694 R 192222 CDS YP_002344560.1 218562781 905459 complement(1098377..1098604) 1 NC_002163.1 Original (2000) note: Cj1169c, probable periplasmic protein, len: 75 aa; no Hp match. Contains probable N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1098604 905459 Cj1169c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344560.1 1098377 R 192222 CDS YP_002344561.1 218562782 905460 complement(1098615..1100036) 1 NC_002163.1 Original (2000) note: Cj1170c, omp50, outer membrane protein, len: 473 aa; no Hp match. Contains N-terminal signal sequence and coiled-coil region between aa 60-90. Identification as an outer membrane protein by M-J. Bolla (Jean-Michel.Bolla@medicine.univ-mrs.fr) personal communication; Updated (2006) note: Further characterisation with attached papers give more information on protein naming. Functional classification - Membranes, lipoproteins and porins; PMID:11104668, PMID:15131219; 50 kda outer membrane protein precursor 1100036 omp50 905460 omp50 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50 kda outer membrane protein precursor YP_002344561.1 1098615 R 192222 CDS YP_002344562.1 218562783 905461 complement(1100192..1100674) 1 NC_002163.1 Original (2000) note: Cj1171c, ppi, probable peptidyl-prolyl cis-trans isomerase, len: 480 aa; similar to many e.g. YPB_BACSU peptidyl-prolyl cis-trans isomerase B (EC 5.2.1.8) (143 aa), fasta scores; opt: 537 z-score: 643.2 E(): 1.6e-28, 56.2% identity in 137 aa overlap. 55.3% identity to HP1441. Contains PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature, and Pfam match to entry PF00160 pro_isomerase,Peptidyl-prolyl cis-trans isomerases; Updated (2006) note: Characterised in Bacillus subtilis with acceptable identity score, so not added to product function. Functional classification -Protein translation and modification; PMID:8022278; peptidyl-prolyl cis-trans isomerase 1100674 ppi 905461 ppi Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptidyl-prolyl cis-trans isomerase YP_002344562.1 1100192 R 192222 CDS YP_002344563.1 218562784 905462 complement(1100684..1101391) 1 NC_002163.1 Original (2000) note: Cj1172c, unknown, len: 235 aa; similar to hypothetical proteins e.g. YEBC_ECOLI (246 aa), fasta scores; opt: 508 z-score: 579.3 E(): 5.7e-25,37.1% identity in 229 aa overlap. 58.1% identity to HP0162; Updated (2006) note: Pfam domain PF01709 Domain of unknown function DUF28 identified within CDS. Conserved added to product function. Functional classification -Conserved hypothetical proteins; hypothetical protein 1101391 905462 Cj1172c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344563.1 1100684 R 192222 CDS YP_002344564.1 218562785 905463 1101500..1101841 1 NC_002163.1 Original (2000) note: Cj1173, possible efflux protein, len: 113 aa; similar to many e.g. EBR_STAAU ethidium bromide resistance protein (107 aa), fasta scores; opt: 232 z-score: 309.2 E(): 6.3e-10, 38.0% identity in 100 aa overlap. No Hp match. Contains Pfam match to entry PF00893 DUF7, Integral membrane protein. Also similar to Cj0310c (27.1% identity in 107 aa overlap); Updated (2006) note: Pfam domain PF00893 Small Multidrug Resistance protein identified within CDS. Also,four probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Some characterisation in Escherichia coli with acceptable identity score. kept within product function. Additional paper (PMID:16048946) giving further information within Campylobacter spp. Functional classification - Drug/analogue sensitivity; PMID:11566977, PMID:15919996, PMID:16048946; multidrug resistance protein 1101841 905463 Cj1173 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 multidrug resistance protein YP_002344564.1 1101500 D 192222 CDS YP_002344565.1 218562786 905464 1101841..1102149 1 NC_002163.1 Original (2000) note: Cj1174, possible efflux protein, len: 102 aa; similar to many e.g. EBR_STAAU ethidium bromide resistance protein (107 aa), fasta scores; opt: 228 z-score: 302.9 E(): 1.4e-09, 33.0% identity in 100 aa overlap. No Hp match. Contains Pfam match to entry PF00893 DUF7, Integral membrane protein. Also similar to Cj0309c (28.7% identity in 94 aa overlap); Updated (2006) note: Pfam domain PF00893 Small Multidrug Resistance protein identified within CDS. Also,four probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Some characterisation in Escherichia coli with acceptable identity score. kept within product function. Additional paper (PMID:16048946) giving further information within Campylobacter spp. Functional classification - Drug/analogue sensitivity; PMID:11566977, PMID:15919996, PMID:16048946; multidrug resistance protein 1102149 905464 Cj1174 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 multidrug resistance protein YP_002344565.1 1101841 D 192222 CDS YP_002344566.1 218562787 905465 complement(1102167..1103759) 1 NC_002163.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1103759 argS 905465 argS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 arginyl-tRNA synthetase YP_002344566.1 1102167 R 192222 CDS YP_002344567.1 218562788 905466 complement(1103771..1104010) 1 NC_002163.1 Original (2000) note: Cj1176c, unknown, len: 79 aa; similar to hypothetical proteins e.g. YY34_MYCTU MTCY49.34C (83 aa), fasta scores; opt: 162 z-score: 221.6 E(): 4.8e-05, 42.9% identity in 56 aa overlap. 49.4% identity to HP0320; Updated (2006) note: Pfam domain PF02416 mttA/Hcf106 family identified within CDS. Members of this protein family are involved in Sec independent translocation mechanism. Product function modified to more specific family member based on motif match. Characterisation has been carried out in Escherichia coli,with acceptable identity score. Product function uses homolog description. Functional classification - Protein and peptide secretion; PMID:9649434, PMID:12427031, PMID:15571732,PMID:9546395, PMID:16027357; Sec-independent protein translocase 1104010 tatA 905466 tatA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Sec-independent protein translocase YP_002344567.1 1103771 R 192222 CDS YP_002344568.1 218562789 905467 complement(1104012..1104635) 1 NC_002163.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1104635 gmk 905467 gmk Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 guanylate kinase YP_002344568.1 1104012 R 192222 CDS YP_002344569.1 218562790 905468 complement(1104632..1106260) 1 NC_002163.1 Original (2000) note: Cj1178c, highly acidic protein, len: 542 aa; no Hp match. Very Asp- Glu- rich; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; highly acidic protein 1106260 905468 Cj1178c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 highly acidic protein YP_002344569.1 1104632 R 192222 CDS YP_002344570.1 218562791 905469 complement(1106317..1107084) 1 NC_002163.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 1107084 fliR 905469 fliR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar biosynthesis protein FliR YP_002344570.1 1106317 R 192222 CDS YP_002344571.1 218562792 905470 complement(1107071..1107706) 1 NC_002163.1 Original (2000) note: Cj1180c, probable ABC transporter ATP binding protein, len: 211 aa; similar to many e.g. YBBA_ECOLI hypothetical ABC transporter ATP-binding protein (228 aa), fasta scores; opt: 457 z-score: 554.6 E(): 1.4e-23, 39.7% identity in 199 aa overlap. 49.5% identity to HP0179. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran, ABC transporters; Updated (2006) note: Similar to many identified as lipoprotein-releasing system ATP-binding protein. kept within product function. Functional classification -Transport/binding proteins - Other; PMID:10783239, PMID:11844772, PMID:12823819; ABC transporter ATP-binding protein 1107706 905470 Cj1180c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter ATP-binding protein YP_002344571.1 1107071 R 192222 CDS YP_002344572.1 218562793 905471 complement(1107719..1108792) 1 NC_002163.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 1108792 tsf 905471 tsf Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 elongation factor Ts YP_002344572.1 1107719 R 192222 CDS YP_002344573.1 218562794 905472 complement(1108792..1109583) 1 NC_002163.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 1109583 rpsB 905472 rpsB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S2 YP_002344573.1 1108792 R 192222 CDS YP_002344574.1 218562795 905473 complement(1109699..1110862) 1 NC_002163.1 Original (2000) note: Cj1183c, cfa, probable cyclopropane-fatty-acyl-phospholipid synthase, len: 387 aa; CFA_ECOLI cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) (381 aa), fasta scores; opt: 721 z-score: 802.3 E(): 0, 38.7% identity in 362 aa overlap. 62.1% identity to HP0416; Updated (2006) note: Pfam domain PF02353 Cyclopropane-fatty-acyl-phosphol lipid synthase identified within CDS. Further support given to product function. Characterised in Escherichia coli with acceptable identity score. Appropiate motifs present. removed from product function. Functional classification - Fatty acid biosynthesis; PMID:1445840; cyclopropane-fatty-acyl-phospholipid synthase 1110862 cfa 905473 cfa Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cyclopropane-fatty-acyl-phospholipid synthase YP_002344574.1 1109699 R 192222 CDS YP_002344575.1 218562796 905474 complement(1110990..1112114) 1 NC_002163.1 Original (2000) note: Cj1184c, petC, possible ubiquinol-cytochrome C reductase cytochrome C subunit,len: 374 aa; some similarity to e.g. CYC_TETPY cytochrome C (109 aa), fasta scores; opt: 124 z-score: 145.5 E(): 0.83, 25.6% identity in 121 aa overlap. 36.4% identity to HP1538. Contains Pfam match to entry PF00034 cytochrome_c,Cytochrome c, probable N-terminal signal sequence, and possible membrane anchor at C-terminus; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Specific characterisation with acceptable identity score not carried out yet, so kept in product function. Literature search identified paper giving further clues to functionality within Campylobacter. Functional classification - Energy metabolism - Electron transport; PMID:16041056; ubiquinol-cytochrome C reductase cytochrome C subunit 1112114 petC 905474 petC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ubiquinol-cytochrome C reductase cytochrome C subunit YP_002344575.1 1110990 R 192222 CDS YP_002344576.1 218562797 905475 complement(1112111..1113361) 1 NC_002163.1 Original (2000) note: Cj1185c, petB, probable ubiquinol-cytochrome C reductase cytochrome B subunit,len: 416 aa; similar to e.g. CYB_RHOSH cytochrome B (EC 1.10.2.2) (444 aa), fasta scores; opt: 1023 z-score: 1190.8 E(): 0, 40.4% identity in 416 aa overlap. 70.9% identity to HP1539; Contains PS00193 Cytochrome b/b6 Qo site signature, Pfam match to entry PF00033 cytochrome_b_N, Cytochrome b(N-terminal)/b6/petB, and Pfam match to entry PF00032 cytochrome_b_C, Cytochrome b(C-terminal)/b6/petD; Updated (2006) note: Ten probable transmembrane helices predicted by TMHMM2.0. Specific characterisation with acceptable identity score carried out in Rhodobacter sphaeroides. kept within product function. Literature search identified paper (PMID:16041056) giving further clues to functionality within Campylobacter. Functional classification - Energy metabolism - Electron transport; PMID:2176595, PMID:1645718, PMID:16041056; ubiquinol-cytochrome C reductase cytochrome B subunit 1113361 petB 905475 petB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ubiquinol-cytochrome C reductase cytochrome B subunit YP_002344576.1 1112111 R 192222 CDS YP_002344577.1 218562798 905476 complement(1113363..1113866) 1 NC_002163.1 Original (2000) note: Cj1186c, petA, probable ubiquinol-cytochrome C reductase iron-sulfur subunit, len: 167 aa; similar to e.g. UCRI_BRAJA ubiquinol-cytochrome C reductase iron-sulfur subunit (EC 1.10.2.2) (176 aa),fatsa scores; opt: 236 z-score: 291.2 E(): 6.4e-09, 39.2% identity in 171 aa overlap. 56.8% identity to HP1540. Contains PS00199 Rieske iron-sulfur protein signature 1,and Pfam match to entry PF00355 Rieske, Rieske iron-sulfur protein; Updated (2006) note: No specific characterisation with acceptable identity score, so kept within product function. Literature search identified paper giving further clues to functionality within Campylobacter. Functional classification - Energy metabolism - Electron transport; PMID:16041056; ubiquinol-cytochrome C reductase iron-sulfur subunit 1113866 petA 905476 petA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ubiquinol-cytochrome C reductase iron-sulfur subunit YP_002344577.1 1113363 R 192222 CDS YP_002344578.1 218562799 905477 complement(1113956..1115242) 1 NC_002163.1 Original (2000) note: Cj1187c, arsB, possible arsenical pump membrane protein, len: 428 aa; simlar to many e.g. ARSB_ECOLI arsenical pump membrane protein (429 aa), fasta scores; opt: 805 z-score: 920.7 E(): 0, 33.5% identity in 433 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02040 Arsenical pump membrane protein identified within CDS. Also, eleven probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised in Escherichia coli with marginal identity score. Appropriate motifs present. removed from product function. Functional classification - Drug/analogue sensitivity; PMID:7721697, PMID:1688427; arsenical pump membrane protein 1115242 arsB 905477 arsB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 arsenical pump membrane protein YP_002344578.1 1113956 R 192222 CDS YP_002344579.1 218562800 905478 complement(1115243..1117102) 1 NC_002163.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 1117102 gidA 905478 gidA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA YP_002344579.1 1115243 R 192222 CDS YP_002344580.1 218562801 905479 complement(1117190..1117687) 1 NC_002163.1 Original (2000) note: Cj1189c, possible signal-transduction sensor protein, len: 165 aa; similar to N-terminus of genes involved in oxygen-sensing e.g. AER_ECOLI aerotaxis receptor (506 aa), fasta scores; opt: 342 z-score: 407.5 E(): 2.1e-15, 36.4% identity in 140 aa overlap, and NIFL_AZOVI nitrogen fixation regulatory protein (519 aa), fasta scores; opt: 175 z-score: 212.5 E(): 0.00015, 33.6% identity in 110 aa overlap. No Hp match. Also similar to Cj1191c (63.4% identity in 161 aa overlap); Updated (2006) note: Pfam domain PF00989 PAS fold identified within CDS. PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. Prosite domain PS50112 PAS, PAS repeat profile identified within CDS. Further support given to product function. Characterisation work carried out in Campylobacter jejuni. Product function updated. Literature search identified paper giving further information on product functionality (PMID:11298288). Gene name added. Functional classification - Signal transduction; PMID:9380671, PMID:11298288; bipartate energy taxis response protein CetB 1117687 cetB 905479 cetB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bipartate energy taxis response protein CetB YP_002344580.1 1117190 R 192222 CDS YP_002344581.1 218562802 905480 complement(1117705..1119084) 1 NC_002163.1 Original (2000) note: Cj1190c, probable MCP-domain signal transduction protein, len: 459 aa; similar to many e.g. TLPC_BACSU methyl-accepting chemotaxis protein TLPC (573 aa), fasta scores; opt: 371 z-score: 397.9 E(): 7.3e-15, 26.2% identity in 404 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00015 MCPsignal,Methyl-accepting chemotaxis protein (MCP) signaling domain, and probable membrane spanning domain at N-terminus; Updated (2006) note: Characterisation work carried out in Campylobacter jejuni. Product function updated. Literature search identified paper giving further information to product functionality (PMID:11298288). New gene name has been added. Functional classification -Signal transduction; PMID:8188684, PMID:11298288; bipartate energy taxis response protein CetA 1119084 cetA 905480 cetA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bipartate energy taxis response protein CetA YP_002344581.1 1117705 R 192222 CDS YP_002344582.1 218562803 905481 complement(1119205..1119699) 1 NC_002163.1 Original (2000) note: Cj1191c, possible signal-transduction sensor protein, len: 164 aa; similar to N-terminus of genes involved in oxygen-sensing e.g. AER_ECOLI aerotaxis receptor (506 aa), fasta scores; opt: 297 z-score: 373.5 E(): 1.7e-13, 34.3% identity in 134 aa overlap, and NIFL_AZOVI nitrogen fixation regulatory protein (519 aa), fasta scores; opt: 178 z-score: 226.6 E(): 2.5e-05, 33.0% identity in 103 aa overlap. No Hp match. Also similar to Cj1189c (63.4% identity in 161 aa overlap); Updated (2006) note: Pfam domain PF00989 PAS fold identified within CDS. PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. Prosite domain PS50112 PAS, PAS repeat profile identified within CDS. Further support given to product function. Product function modified to include motif information. Literature search identified paper giving further clues to product functionality (PMID:11298288). Functional classification - Signal transduction; PMID:9380671, PMID:11298288; PAS domain containing signal-transduction sensor protein 1119699 905481 Cj1191c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 PAS domain containing signal-transduction sensor protein YP_002344582.1 1119205 R 192222 CDS YP_002344583.1 218562804 905482 1119968..1121344 1 NC_002163.1 Original (2000) note: Cj1192, dctA, probable C4-dicarboxylate transport protein, len: 458 aa; similar to many e.g. DCTA_ECOLI C4-dicarboxylate transport protein (428 aa), fasta scores; opt: 1073 z-score: 1222.5 E(): 0,45.3% identity in 433 aa overlap. No Hp match. Contains Pfam match to entry PF00375 SDF, Sodium:dicarboxylate symporter family; Updated (2006) note: Eight probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised in Escherichia coli with acceptable identity score. kept within product function. Functional classification - Carbohydrates,organic acids and alcohols; PMID:8955389, PMID:10482502, PMID:15919996,PMID:11803016; C4-dicarboxylate transport protein 1121344 dctA 905482 dctA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 C4-dicarboxylate transport protein YP_002344583.1 1119968 D 192222 CDS YP_002344584.1 218562805 905483 complement(1121341..1122147) 1 NC_002163.1 Original (2000) note: Cj1193c, probable periplasmic protein, len: 268 aa; no Hp match. Contains probable N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1122147 905483 Cj1193c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344584.1 1121341 R 192222 CDS YP_002344585.1 218562806 905484 1122289..1123815 1 NC_002163.1 Original (2000) note: Cj1194, possible phosphate permease, len: 508 aa; similar to many predicted phosphate permeases e.g. TR:Q50684 Mycobacterium tuberculosis phosphate permease Rv2281 MTCY339.29C (552 aa),fasta scores; opt: 900 z-score: 971.5 E(): 0, 46.6% identity in 511 aa overlap. 32.7% identity to HP1491; Updated (2006) note: Pfam domain PF01384 Phosphate transporter family identified within CDS. Also, thirteen probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. No specific characterisation has been carried out yet, so kept within product function. Functional classification -Transport/binding proteins - Anions; phosphate permease 1123815 905484 Cj1194 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphate permease YP_002344585.1 1122289 D 192222 CDS YP_002344586.1 218562807 905485 complement(1123823..1125001) 1 NC_002163.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; dihydroorotase 1125001 pyrC2 905485 pyrC2 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dihydroorotase YP_002344586.1 1123823 R 192222 CDS YP_002344587.1 218562808 905486 complement(1125011..1125907) 1 NC_002163.1 NAD(P)+; catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1125907 gpsA 905486 gpsA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_002344587.1 1125011 R 192222 CDS YP_002344588.1 218562809 905487 complement(1125904..1127322) 1 NC_002163.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 1127322 gatB 905487 gatB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_002344588.1 1125904 R 192222 CDS YP_002344589.1 218562810 905488 1127437..1127931 1 NC_002163.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 1127931 905488 Cj1198 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 S-ribosylhomocysteinase YP_002344589.1 1127437 D 192222 CDS YP_002344590.1 218562811 905489 1128243..1129235 1 NC_002163.1 Original (2000) note: Cj1199, probable iron/ascorbate-dependent oxidoreductase, len: 330 aa; similar to many eukaryotic oxidoreductases e.g. LDOX_MALSP Malus sp. (crab apple) leucoanthocyanidin dioxygenase (EC 1.-.-.-) (357 aa), fasta scores; opt: 334 z-score: 386.2 E(): 3.3e-14, 25.2% identity in 313 aa overlap, and ACCO_MALDO Malus domesticus (apple) 1-aminocyclopropane-1-carboxylate oxidase (314 aa), fasta scores; opt: 301 z-score: 349.6 E(): 3.6e-12, 26.7% identity in 303 aa overlap. No Hp match. Contains Pfam match to entry PF00671 Fe_Asc_oxidored, Iron/Ascorbate family of oxidoreductases; Updated (2006) note: Pfam domain PF03171 2OG-Fe(II) oxygenase superfamily identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score has been carried out yet. kept in product function. Functional classification - Misc; iron/ascorbate-dependent oxidoreductase 1129235 905489 Cj1199 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 iron/ascorbate-dependent oxidoreductase YP_002344590.1 1128243 D 192222 CDS YP_002344591.1 218562812 905490 1129228..1130016 1 NC_002163.1 Original (2000) note: Cj1200, probable periplasmic protein, len: 262 aa; similar to members of the nlpA family of outem membrane lipoproteins, e.g. NLPA_ECOLI lipoprotein-28 precursor (272 aa), fasta scores; opt: 560 z-score: 650.6 E(): 6.1e-29, 39.7% identity in 239 aa overlap, and PLPC_PASHA outer membrane lipoprotein 3 precursor (263 aa), fasta scores; opt: 564 z-score: 655.4 E(): 3.3e-29, 38.6% identity in 259 aa overlap. No Hp ortholog. Contains probable N-terminal signal sequence. Also similar to Cj0772c (57.5% identity in 254 aa overlap), Cj0771c (45.6% identity in 259 aa overlap), and Cj0770c (44.9% identity in 256 aa overlap); Updated (2006) note: Pfam domain PF03180 NLPA lipoprotein identified within CDS. Characterised in Escherichia coli as lipoprotein-28 precursor. Recent work has led to classification of some similar CDS's as D-methionine-binding lipoprotein metQ precursor. Product function modified to more specific family member. kept within product function. Functional classification -Miscellaneous periplasmic proteins; PMID:3003106, PMID:12169620; NLPA family lipoprotein 1130016 905490 Cj1200 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NLPA family lipoprotein YP_002344591.1 1129228 D 192222 CDS YP_002344592.1 218562813 905491 1130028..1132292 1 NC_002163.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 1132292 metE 905491 metE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase YP_002344592.1 1130028 D 192222 CDS YP_002344593.1 218562814 905492 1132302..1133150 1 NC_002163.1 Original (2000) note: Cj1202, metF, probable 5,10-methylenetetrahydrofolate reductase, len: 282 aa; similar to e.g. METF_ECOLI 5,10-methylenetetrahydrofolate reductase (EC 1.7.99.5) (296 aa), fasta scores; opt: 529 z-score: 613.4 E(): 7.2e-27 33.0% identity in 264 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02219 Methylenetetrahydrofolate reductase was identified within CDS. Characterised in Escherichia coli with marginal identity score. Appropriate motifs present. not added to product function. Functional classification -Central intermediary metabolism - General; PMID:6356036, PMID:10201405; 5,10-methylenetetrahydrofolate reductase 1133150 metF 905492 metF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 5,10-methylenetetrahydrofolate reductase YP_002344593.1 1132302 D 192222 CDS YP_002344594.1 218562815 905493 complement(1133172..1133363) 1 NC_002163.1 Original (2000) note: Cj1203c, probable integral membrane protein, len: 63 aa; no Hp match; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Functional classification -Central intermediary metabolism - General; integral membrane protein 1133363 905493 Cj1203c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344594.1 1133172 R 192222 CDS YP_002344595.1 218562816 905494 complement(1133360..1134040) 1 NC_002163.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 1134040 atpB 905494 atpB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 F0F1 ATP synthase subunit A YP_002344595.1 1133360 R 192222 CDS YP_002344596.1 218562817 905495 complement(1134109..1135449) 1 NC_002163.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 1135449 radA 905495 radA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA repair protein RadA YP_002344596.1 1134109 R 192222 CDS YP_002344597.1 218562818 905496 complement(1135449..1136315) 1 NC_002163.1 Original (2000) note: Cj1206c, ftsY, probable signal recognition particle protein, len: 288 aa; similar to e.g. FTSY_ECOLI cell division protein FTSY (497 aa),fasta scores; opt: 663 z-score: 759.0 E(): 0, 43.3% identity in 298 aa overlap, and PILA_NEIME probable signal recognition particle protein (421 aa), fasta scores; opt: 633 z-score: 726.0 E(): 3.8e-33, 39.9% identity in 298 aa overlap. 48.6% identity to HP0763. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00300 SRP54-type proteins GTP-binding domain signature, and Pfam match to entry PF00448 SRP54, SRP54-type protein. Also similar to Cj0709 ffh (31.4% identity in 271 aa overlap); Updated (2006) note: Similar to more than one bacteria with acceptable identity score. kept within product function. Functional classification -Protein and peptide secretion; PMID:10048040, PMID:9188744, PMID:8194520; signal recognition particle protein 1136315 ftsY 905496 ftsY Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 signal recognition particle protein YP_002344597.1 1135449 R 192222 CDS YP_002344598.1 218562819 905497 complement(1136315..1136872) 1 NC_002163.1 Original (2000) note: Cj1207c, possible lipoprotein thiredoxin, len: 185 aa; some similarity to TR:G4100188 (EMBL:U95250) Treponema pallidum predicted thioredoxin (185 aa), fasta scores; opt: 196 z-score: 242.3 E(): 3.4e-06, 31.5% identity in 111 aa overlap, and HELX_RHOCA thiol:disulfide interchange protein(176 aa), fatsa scores; opt: 153 z-score: 192.6 E(): 0.002, 23.2% identity in 142 aa overlap. 23.7% identity to HP0762. Also similar to Cj1106 (29.4% identity in 201 aa overlap). Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Prosite domain PS50223 THIOREDOXIN_2, Thioredoxin domain 2 was identified within CDS. Further support given to product function. kept within product function. Functional classification -Energy metabolism - Electron transport; lipoprotein thiredoxin 1136872 905497 Cj1207c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein thiredoxin YP_002344598.1 1136315 R 192222 CDS YP_002344599.1 218562820 905498 1136955..1137581 1 NC_002163.1 Original (2000) note: Cj1208, unknown, len: 208 aa; similar to hypothetical proteins e.g. YGFA_HAEIN HI0858 (187 aa), fasta scores; opt: 150 z-score: 196.6 E(): 0.0012, 26.8% identity in 164 aa overlap. 27.8% identity to HP0761; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Pfam domain PF01812 5-formyltetrahydrofolate cyclo-ligase family identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out in related bacteria, so kept within product function. Functional classification -Purine ribonucleotide biosynthesis; 5-formyltetrahydrofolate cyclo-ligase family protein 1137581 905498 Cj1208 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 5-formyltetrahydrofolate cyclo-ligase family protein YP_002344599.1 1136955 D 192222 CDS YP_002344600.1 218562821 905499 1137502..1139055 1 NC_002163.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP; phosphodiesterase 1139055 905499 Cj1209 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphodiesterase YP_002344600.1 1137502 D 192222 CDS YP_002344601.1 218562822 905500 1139064..1139621 1 NC_002163.1 Original (2000) note: Cj1210, probable integral membrane protein, len: 185 aa; similar to members of the dedA family e.g. DEDA_ECOLI DEDA protein (219 aa), fasta scores; opt: 193 z-score: 248.3 E(): 1.6e-06, 26.7% identity in 172 aa overlap. 35.6% identity to HP1162. Also similar to Cj0928 (27.7% identity in 177 aa overlap), and Cj1168c (23.0% identity in 200 aa overlap). Contains Pfam match to entry PF00597 DedA, DedA family; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 1139621 905500 Cj1210 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344601.1 1139064 D 192222 CDS YP_002344602.1 218562823 905501 1139621..1140880 1 NC_002163.1 Original (2000) note: Cj1211, probable integral membrane protein, len: 419 aa; similar to hypothetical membrane proteins e.g. TR:O51537 (EMBL:AE001160) BB0591 (416 aa), fasta scores; opt: 222 z-score: 251.2 E(): 1.1e-06, 26.4% identity in 405 aa overlap. 33.9% identity to HP1361 (called competence locus E (comE3)); Updated (2006) note: Pfam motif PF03772 Competence protein was identified within CDS. Nine probable transmembrane helices predicted by TMHMM2.0. Product function modified to more specific family member based on motif match. No specific characterisation with acceptable identity score carried out yet, so kept in product function. Functional classification - Membranes,lipoproteins and porins; PMID:7968523; competence family protein 1140880 905501 Cj1211 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 competence family protein YP_002344602.1 1139621 D 192222 CDS YP_002344603.1 218562824 905502 complement(1140824..1141630) 1 NC_002163.1 Original (2000) note: Cj1212c, rbn, possible ribonuclease BN, len: RBN_ECOLI ribonuclease BN (EC 3.1.-.-) (290 aa), fasta scores; opt: 365 z-score: 430.3 E(): 1.1e-16, 28.5% identity in 242 aa overlap. 29.2% identity to HP1407; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Characterised in Escherichia coli with marginal identity score. kept within product function. Functional classification -Aminoacyl tRNA synthetases and their modification; PMID:8955422; ribonuclease BN 1141630 rbn 905502 rbn Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribonuclease BN YP_002344603.1 1140824 R 192222 CDS YP_002344604.1 218562825 905503 complement(1141634..1143016) 1 NC_002163.1 Original (2000) note: Cj1213c, glcD, probable glycolate oxidase subunit D, len: 460 aa; similar to e.g. GLCD_ECOLI glycolate oxidase subunit GLCD (499 aa), fasta scores; opt: 952 z-score: 1099.5 E(): 0, 37.0% identity in 419 aa overlap. 64.8% identity to HP0509; Updated (2006) note: Pfam domains PF02913 FAD linked oxidases, C-terminal domain and PF01565 FAD binding domain were identified within CDS. Further support given to product function. Characterised in Escherichia coli with marginal identity score. kept in product function. Functional classification - Degradation - Carbon compounds; PMID:8606183, PMID:11283302; glycolate oxidase subunit D 1143016 glcD 905503 glcD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glycolate oxidase subunit D YP_002344604.1 1141634 R 192222 CDS YP_002344605.1 218562826 905504 complement(1143019..1143744) 1 NC_002163.1 Original (2000) note: Cj1214c, unknown, len: 241 aa; similar to N-terminal half of HP0508 (452 aa) (24.9% identity in 245 aa overlap); Updated (2006) note: One signal peptide predicted by SignalP 2.0 HMM. Product function modified to more specific family member. kept within product function. Paper identified linking protein to glycoprotein (PMID:12186869). Functional classification -Transport/binding proteins - Other; PMID:12186869; exporting protein 1143744 905504 Cj1214c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 exporting protein YP_002344605.1 1143019 R 192222 CDS YP_002344606.1 218562827 905505 1143866..1145026 1 NC_002163.1 Original (2000) note: Cj1215, probable periplasmic protein, len: 386 aa; similar to hypothetical proteins e.g. YEBA_ECOLI (419 aa), fasta scores; opt: 491 z-score: 556.7 E(): 1e-23, 30.2% identity in 338 aa overlap. 44.0% identity to HP0506. Also similar, in part, to Cj1087c (40.6% identity in 133 aa overlap), and Cj1235 (29.6% identity in 206 aa overlap); Updated (2006) note: Pfam domain PF01551 Peptidase family M23 identified within CDS. Further support given to product function. Product modified to more specific family member based on motif results. No specific characterisation has been carried out yet, so kept within product function. Functional classification -Degradation of macromolecules - Proteins, peptides and glycopeptides; peptidase M23 family protein 1145026 905505 Cj1215 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptidase M23 family protein YP_002344606.1 1143866 D 192222 CDS YP_002344607.1 218562828 905506 complement(1145023..1145226) 1 NC_002163.1 Original (2000) note: Cj1216c, unknown, len: 67 aa; no Hp match. Functional classification - Unknown; hypothetical protein 1145226 905506 Cj1216c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344607.1 1145023 R 192222 CDS YP_002344608.1 218562829 905507 complement(1145228..1145908) 1 NC_002163.1 Original (2000) note: Cj1217c, unknown, len: 226 aa; similar to hypothetical proteins e.g. YFIH_ECOLI (243 aa), fasta scores; opt: 262 z-score: 319.9 E(): 1.6e-10,30.3% identity in 185 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02578 Uncharacterised ACR, YfiH family COG1496 identified within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 1145908 905507 Cj1217c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344608.1 1145228 R 192222 CDS YP_002344609.1 218562830 905508 complement(1145872..1146483) 1 NC_002163.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1146483 ribA 905508 ribA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 riboflavin synthase subunit alpha YP_002344609.1 1145872 R 192222 CDS YP_002344610.1 218562831 905509 complement(1146492..1149032) 1 NC_002163.1 Original (2000) note: Cj1219c, probable periplasmic protein, len: 846 aa; 27.3% identity to HP0358. Weak similarity to FLID_ECOLI flagellar hook-associated protein 2 (467 aa), fasta scores; opt: 168 z-score: 180.0 E(): 0.0099, 24.2% identity in 446 aa overlap, and to Cj0530 (22.1% identity in 891 aa overlap). Contains probable N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1149032 905509 Cj1219c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344610.1 1146492 R 192222 CDS YP_002344611.1 218562832 905510 1149194..1149454 1 NC_002163.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1149454 groES 905510 groES Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 co-chaperonin GroES YP_002344611.1 1149194 D 192222 CDS YP_002344612.1 218562833 905511 1149475..1151112 1 NC_002163.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 1151112 groEL 905511 groEL Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molecular chaperone GroEL YP_002344612.1 1149475 D 192222 CDS YP_002344613.1 218562834 905512 complement(1151155..1152345) 1 NC_002163.1 Original (2000) note: Cj1222c, probable two-component sensor (histidine kinase), len: 396 aa; similar to many sensor proteins e.g. RSTB_ECOLI sensor protein RSTB (433 aa), fasta scores; opt: 226 z-score: 267.7 E(): 1.3e-07, 24.5% identity in 237 aa overlap. 28.5% identity to HP1364. Contains Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain, and two possible membrane spanning domains; Updated (2006) note: Pfam domains PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase motif and PF00512 His Kinase A (phosphoacceptor) domain were identified within CDS. Prosite domain PS50109 HIS_KIN,Histidine kinase domain profile was also identified within CDS. Also, two probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised in Campylobacter jejuni. Literature search identified characterisation paper where Cj1222c and Cj1223c were shown to be required for optimal colonization and were termed dccRS (diminished capacity to colonize) two-component system. Functional classification - Signal transduction; PMID:15554967; two-component sensor histidine kinase 1152345 dccS 905512 dccS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 two-component sensor histidine kinase YP_002344613.1 1151155 R 192222 CDS YP_002344614.1 218562835 905513 complement(1152338..1153003) 1 NC_002163.1 Original (2000) note: Cj1223c, probable two-component regulator, len: 221 aa; similar to many e.g. CIAR_STRPN transcriptional regulatory protein CIAR (224 aa), fasta scores; opt: 426 z-score: 522.6 E(): 8.2e-22,37.0% identity in 219 aa overlap. 39.4% identity to HP1365. Contains Pfam match to entry PF00072 response_reg,Response regulator receiver domain, and Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal; Updated (2006) note: Characterised in Campylobacter jejuni. Literature search identified characterisation paper where Cj1222c and Cj1223c were shown to required for optimal colonization and were termed dccRS (diminished capacity to colonize) two-component system. Functional classification - Signal transduction; PMID:15554967; two-component regulator 1153003 dccR 905513 dccR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 two-component regulator YP_002344614.1 1152338 R 192222 CDS YP_002344615.1 218562836 905514 1153151..1153750 1 NC_002163.1 Original (2000) note: Cj1224, possible iron-binding protein, len: 199 aa; some simlarity to TR:Q58157 (EMBL:U67520) Methanococcus jannaschii MJ0747 (169 aa),fasta scores; opt: 230 z-score: 274.3 E(): 5.6e-08, 33.9% identity in 127 aa overlap. Weak similarity to members of the eukaryotic oxygen-binding hemerythrin family, e.g. HEMM_THEZO myohemerythrin (118 aa), fasta scores; opt: 159 z-score: 196.6 E(): 0.0012, 30.5% identity in 118 aa overlap. Note that all of the iron-binding residues are conserved. No Hp match. Also similar to Cj0045c (29.2% identity in 202 aa overlap), Cj0072c (pseudogene), and Cj0241c (34.7% identity in 118 aa overlap); Updated (2006) note: Pfam domain (x2) PF01814 Hemerythrin HHE cation binding domain identified within CDS. Prosite domain PS00550 HEMERYTHRINS, Hemerythrin family signature also identified within CDS. Further support given to product function. Specific characterisation has not been carried out yet, so kept within product function. Functional classification -Transport/binding proteins - Cations; iron-binding protein 1153750 905514 Cj1224 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 iron-binding protein YP_002344615.1 1153151 D 192222 CDS YP_002344616.1 218562837 905515 1153761..1154009 1 NC_002163.1 Original (2000) note: Cj1225, unknown, len: 82 aa; weak similarity to CDS from Borrelia burgdorferi repeated DNA element TR:Q45025 (EMBL:X87127) (210 aa), fasta scores; opt: 117 z-score: 159.0 E(): 0.15, 33.3% identity in 78 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF01402 Ribbon-helix-helix protein, copG family identified within CDS. No specific characterisation has yet been carried out yet. Functional classification - Conserved hypothetical proteins; hypothetical protein 1154009 905515 Cj1225 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344616.1 1153761 D 192222 CDS YP_002344617.1 218562838 905517 complement(1154267..1155514) 1 NC_002163.1 Original (2000) note: Cj1226c, probable two-component sensor (histidine kinase), len: 415 aa; similar to many sensor proteins e.g. CPXA_ECOLI sensor protein CPXA (457 aa), fasta scores; opt: 205 z-score: 241.7 E(): 3.7e-06, 25.2% identity in 270 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00512 signal,Signal carboxyl-terminal domain, and two possible membrane spanning domains. Also similar to Cj1262 (31.0% identity in 410 aa overlap); Updated (2006) note: Pfam domains PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase motifs,PF00512 His Kinase A (phosphoacceptor) domain and PF00672 HAMP domain were all identified within CDS. Also, PS50109 HIS_KIN, Histidine kinase domain profile was identified within CDS. Further support given to product function. Product function modified to include motif information. Specific characterisation has not been carried out yet, so kept within product function. Functional classification - Signal transduction; two-component sensor 1155514 905517 Cj1226c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 two-component sensor YP_002344617.1 1154267 R 192222 CDS YP_002344618.1 218562839 905518 complement(1155511..1156185) 1 NC_002163.1 Original (2000) note: Cj1227c, probable two-component regulator, len: 224 aa; identical to TR:Q46095 (EMBL:U27271) C. jejuni CDS (called ompR) (198 aa), and similar to many e.g. YYCF_BACSU hypothetical 27.2 kd sensory transduction protein (235 aa), fasta scores; opt: 490 z-score: 561.1 E(): 5.9e-24, 36.4% identity in 225 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain, and Pfam match to entry PF00486 trans_reg_C,Transcriptional regulatory protein, C terminal. Also similar to Cj1261 (50.7% identity in 223 aa overlap); Updated (2006) note: Similar to more than one type of two-component regulator with acceptable identity scores, so kept within product function. Literature search identified paper giving further clues to product function. Functional classification - Signal transduction; PMID:15901688, PMID:2402249; two-component regulator 1156185 905518 Cj1227c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 two-component regulator YP_002344618.1 1155511 R 192222 CDS YP_002344619.1 218562840 905519 complement(1156261..1157679) 1 NC_002163.1 Original (2000) note: Cj1228c, htrA, probable serine protease (protease DO), len: 472 aa; 99.2% identical to TR:Q46120 (EMBL:X82628) C. jejuni serine protease htrA (472 aa), and similar to e.g. HTRA_ECOLI protease DO precursor (EC 3.4.21.-) (474 aa), fasta scores; opt: 965 z-score: 1004.5 E(): 0, 39.5% identity in 461 aa overlap. 50.5% identity to HP1019. Contains Pfam match to entry PF00089 trypsin, and 2x Pfam match to entry PF00595 PDZ, PDZ domain; Updated (2006) note: Characterised in Escherichia coli and Campylobacter jejuni, so not added to product function. Functional classification - Degradation of macromolecules - Proteins, peptides and glycopeptides; PMID:15933023, PMID:16041056; serine protease 1157679 htrA 905519 htrA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 serine protease YP_002344619.1 1156261 R 192222 CDS YP_002344620.1 218562841 905520 1157879..1158772 1 NC_002163.1 Original (2000) note: Cj1229, cbpA, probable curved-DNA binding protein, len: 297 aa; similar to e.g. CBPA_ECOLI curved DNA-binding protein (306 aa), fatsa scores; opt: 514 z-score: 550.9 E(): 2.2e-23, 32.8% identity in 287 aa overlap. 52.0% identity to HP1024. Contains S00636 Nt-dnaJ domain signature, and Pfam match to entry PF00226 DnaJ, DnaJ domain; Updated (2006) note: Pfam domain PF01556 DnaJ C terminal region identified within CDS. Further support given to product function. Characterised in Escherichia coli with marginal identity score. kept within product function. Functional classification - Chaperones,chaperonins, heat shock; PMID:15184371, PMID:10947847, PMID:10551881; curved-DNA binding protein 1158772 cbpA 905520 cbpA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 curved-DNA binding protein YP_002344620.1 1157879 D 192222 CDS YP_002344621.1 218562842 905521 1158788..1159162 1 NC_002163.1 Original (2000) note: Cj1230, hspR, possible heat shock transcriptional regulator, len: 124 aa; similar to SPR_STRCO heat shock protein HSPR (151 aa), fatsa scores; opt: 309 z-score: 385.2 E(): 3.7e-14, 42.4% identity in 118 aa overlap, and to other members of the MerR family of transcriptional regulators. 63.3% identity to HP1025. Contains PS00552 Bacterial regulatory proteins,merR family signature, Pfam match to entry PF00376 merR,and probable helix-turn-helix motif at aa 11-32 (Score 1333, +3.73 SD); Updated (2006) note: Characterised in Campylobacter jejuni (PMID:15758235). removed from product function. Functional classification - Chaperones,chaperonins, heat shock; PMID: PMID:8801421, PMID:15758235,PMID:10564507, PMID:15720562; heat shock transcriptional regulator 1159162 hspR 905521 hspR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 heat shock transcriptional regulator YP_002344621.1 1158788 D 192222 CDS YP_002344622.1 218562843 905522 1159168..1160793 1 NC_002163.1 Original (2000) note: Cj1231, kefB, probable glutathione-regulated potassium-efflux system protein,len: 541 aa; similar to e.g. KEFC_ECOLI glutathione-regulated potassium-efflux system protein (620 aa), fasta scores; opt: 803 z-score: 903.5 E(): 0, 30.8% identity in 494 aa overlap. 37.7% identity to HP0471; Updated (2006) note: Pfam domains PF02254 TrkA-N domain and PF00999 Sodium/hydrogen exchanger family were identified within CDS. Also, thirteen probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Identity scores for matching Escherichia coli were marginal. kept within product function. Functional classification -Transport/binding proteins - Cations; PMID:2046548, PMID:1325937; glutathione-regulated potassium-efflux system protein 1160793 kefB 905522 kefB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glutathione-regulated potassium-efflux system protein YP_002344622.1 1159168 D 192222 CDS YP_002344623.1 218562844 905523 1160803..1161135 1 NC_002163.1 Original (2000) note: Cj1232, unknown, len: 110 aa; no Hp match. Lys-rich. Functional classification -Unknown; hypothetical protein 1161135 905523 Cj1232 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344623.1 1160803 D 192222 CDS YP_002344624.1 218562845 905524 1161132..1161752 1 NC_002163.1 Original (2000) note: Cj1233, probable hydrolase,len: 206 aa; similar to e.g. GPH_ECOLI phosphoglycolate phosphatase (252 aa), fasta scores; opt: 177 z-score: 216.3 E(): 9.5e-05, 27.6% identity in 199 aa overlap. No Hp match. Contains Pfam match to entry PF00702 Hydrolase,haloacid dehalogenase-like hydrolase. Also similar to Cj1477c (27.3% identity in 205 aa overlap); Updated (2006) note: Characterisation work within Escherichia coli, however, identity scores were marginal. Product modified to more specific family member based on motif matches. kept within product function. Functional classification - Misc; PMID:13129953, PMID:10572959; HAD-superfamily hydrolase 1161752 905524 Cj1233 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 HAD-superfamily hydrolase YP_002344624.1 1161132 D 192222 CDS YP_002344625.1 218562846 905525 1161808..1163802 1 NC_002163.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 1163802 glyS 905525 glyS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glycyl-tRNA synthetase subunit beta YP_002344625.1 1161808 D 192222 CDS YP_002344626.1 218562847 905526 1163799..1164620 1 NC_002163.1 Original (2000) note: Cj1235, probable periplasmic protein, len: 273 aa; similar to many e.g. TR:Q57503 (EMBL:U07173) Vibrio cholerae ToxR-activated gene, tagE (302 aa), fasta scores; opt: 319 z-score: 373.7 E(): 1.6e-13, 37.0% identity in 192 aa overlap, and YEBA_ECOLI (419 aa), fasta scores; opt: 299 z-score: 348.5 E(): 4.1e-12, 44.3% identity in 115 aa overlap. No Hp ortholog. Also similar to Cj0131 (30.2% identity in 222 aa overlap),Cj1087c (40.7% identity in 123 aa overlap), and Cj1215 (29.6% identity in 206 aa overlap); Updated (2006) note: Pfam domain PF01551 Peptidase family M23 identified within CDS. Further support given to product function. Product modified to more specific family member based on motif results. No specific characterisation has been carried out yet, so kept within product function. Functional classification -Degradation of macromolecules - Proteins, peptides and glycopeptides; peptidase M23 family protein 1164620 905526 Cj1235 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptidase M23 family protein YP_002344626.1 1163799 D 192222 CDS YP_002344627.1 218562848 905527 1164617..1165567 1 NC_002163.1 Original (2000) note: Cj1236, unknown, len: 316 aa; similar to hypothetical proteins e.g. TR:O66873 (EMBL:AE000698) Aquifex aeolicus AQ_622 (320 aa), fasta scores; opt: 263 z-score: 318.9 E(): 1.8e-10, 23.8% identity in 323 aa overlap. 32.4% identity to HP0812; Updated (2006) note: Pfam domain PF02636 Uncharacterized ACR, COG1565 identified within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 1165567 905527 Cj1236 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344627.1 1164617 D 192222 CDS YP_002344628.1 218562849 905528 complement(1165564..1166538) 1 NC_002163.1 Original (2000) note: Cj1237c, possible phosphatase, len: 324 aa; weak similarity to e.g. GPPA_ECOLI guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (494 aa), fasta scores; opt: 174 z-score: 201.9 E(): 0.0006, 25.7% identity in 323 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02541 Ppx/GppA phosphatase family was identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet, so kept within product function (previously was posssible). Functional classification -Misc; phosphatase 1166538 905528 Cj1237c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphatase YP_002344628.1 1165564 R 192222 CDS YP_002344629.1 218562850 905529 1166594..1167367 1 NC_002163.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 1167367 pdxJ 905529 pdxJ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 pyridoxine 5'-phosphate synthase YP_002344629.1 1166594 D 192222 CDS YP_002344630.1 218562851 905530 1167364..1168458 1 NC_002163.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 1168458 pdxA 905530 pdxA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 4-hydroxythreonine-4-phosphate dehydrogenase YP_002344630.1 1167364 D 192222 CDS YP_002344631.1 218562852 905531 complement(1168448..1169050) 1 NC_002163.1 Original (2000) note: Cj1240c, probable periplasmic protein, len: 200 aa; no Hp match. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 1169050 905531 Cj1240c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344631.1 1168448 R 192222 CDS YP_002344632.1 218562853 905532 1169163..1170362 1 NC_002163.1 Original (2000) note: Cj1241, probable transmembrane transport protein, len: 399 aa; similar to e.g. ARAJ_ECOLI protein ARAJ precursor (394 aa), fasta scores; opt: 579 z-score: 680.4 E(): 1.3e-30, 28.8% identity in 385 aa overlap, and CMLR_STRLI chloramphenicol resistance protein (392 aa), fasta scores; opt: 444 z-score: 523.2 E(): 7.6e-22, 25.5% identity in 380 aa overlap. 27.4% identity to HP1185; Updated (2006) note: Pfam domain PF07690 Major Facilitator Superfamily identified within CDS. Also,twelve probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member based on motif match. No specific characterisation with acceptable identity score carried out yet, so kept within product function. Literature search identified paper giving further clues to product function. Functional classification - Transport/binding proteins - Other; PMID:16048946; MFS transport protein 1170362 905532 Cj1241 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MFS transport protein YP_002344632.1 1169163 D 192222 CDS YP_002344633.1 218562854 905533 1170418..1170738 1 NC_002163.1 Original (2000) note: Cj1242, unknown, len: 106 aa; no Hp match; Updated (2006) note: Literature search identified papers giving potential clues to product function. Functional classification - Unknown; PMID:14985343, PMID:15812042; hypothetical protein 1170738 905533 Cj1242 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344633.1 1170418 D 192222 CDS YP_002344634.1 218562855 905534 1170922..1171944 1 NC_002163.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 1171944 hemE 905534 hemE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 uroporphyrinogen decarboxylase YP_002344634.1 1170922 D 192222 CDS YP_002344635.1 218562856 905535 1171941..1172843 1 NC_002163.1 Original (2000) note: Cj1244, unknown, len: 300 aa; similar to hypothetical proteins e.g. YD12_METJA Methanococcus jannaschii MJ1312 (321 aa), fasta scores; opt: 436 z-score: 499.9 E(): 1.5e-20, 30.7% identity in 313 aa overlap. 40.1% identity to HP0117; Updated (2006) note: Pfam domain PF04055 Radical SAM superfamily identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation carried out yet, so kept within product function. Functional classification -Misc; radical SAM domain protein 1172843 905535 Cj1244 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 radical SAM domain protein YP_002344635.1 1171941 D 192222 CDS YP_002344636.1 218562857 905536 complement(1172840..1174036) 1 NC_002163.1 Original (2000) note: Cj1245c, possible membrane protein, len: 398 aa; no Hp match; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; hypothetical protein 1174036 905536 Cj1245c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344636.1 1172840 R 192222 CDS YP_002344637.1 218562858 905537 complement(1174038..1175840) 1 NC_002163.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1175840 uvrC 905537 uvrC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 excinuclease ABC subunit C YP_002344637.1 1174038 R 192222 CDS YP_002344638.1 218562859 905538 complement(1175833..1176327) 1 NC_002163.1 Original (2000) note: Cj1247c, unknown, len: 164 aa; 27.1% identity to HP0820. Functional classification -Conserved hypothetical proteins; hypothetical protein 1176327 905538 Cj1247c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344638.1 1175833 R 192222 CDS YP_002344639.1 218562860 905539 1176466..1178001 1 NC_002163.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1178001 guaA 905539 guaA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GMP synthase YP_002344639.1 1176466 D 192222 CDS YP_002344640.1 218562861 905540 1178087..1179547 1 NC_002163.1 Original (2000) note: Cj1249, unknown, len: 486 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 1179547 905540 Cj1249 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344640.1 1178087 D 192222 CDS YP_002344641.1 218562862 905541 1179787..1181037 1 NC_002163.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 1181037 purD 905541 purD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoribosylamine--glycine ligase YP_002344641.1 1179787 D 192222 CDS YP_002344642.1 218562863 905542 1181034..1181486 1 NC_002163.1 Original (2000) note: Cj1251, unknown, len: 150 aa; similar to hypothetical proteins e.g. TR:Q56614 (EMBL:U39068) Vibrio cholerae orfY (145 aa), fasta scores; opt: 220 z-score: 291.8 E(): 5.9e-09, 28.6% identity in 140 aa overlap. 27.9% identity to HP1217; Updated (2006) note: Pfam domain PF06271 RDD family identified within CDS. Also, two probable transmembrane helices predicted by TMHMM2.0. Functional classification -Conserved hypothetical proteins; hypothetical protein 1181486 905542 Cj1251 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344642.1 1181034 D 192222 CDS YP_002344643.1 218562864 905543 1181476..1183524 1 NC_002163.1 Original (2000) note: Cj1252, probable periplasmic protein, len: 682 aa; some similarity to proteins involved in outer membrane permeability e.g. OSTA_ECOLI organic solvent tolerance protein precursor (784 aa), fasta scores; opt: 223 z-score: 255.4 E(): 6.3e-07, 20.3% identity in 507 aa overlap. 27.9% identity to HP1216. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF04453 Organic solvent tolerance protein identified within CDS. No specific characterisation with acceptable identity score identified yet, so kept within product function. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 1183524 905543 Cj1252 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344643.1 1181476 D 192222 CDS YP_002344644.1 218562865 905544 1183594..1185753 1 NC_002163.1 Original (2000) note: Cj1253, pnp, probable polyribonucleotide nucleotidyltransferase, len: 719 aa; similar to e.g. PNP_ECOLI polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (711 aa), fasta scores; opt: 1068 z-score: 1130.9 E(): 0, 38.9% identity in 730 aa overlap. 49.2% identity to HP1213. Contains Pfam match to entry PF00575 S1, S1 RNA binding domain, Pfam match to entry PF00013 KH-domain, KH domain family of RNA binding proteins, and Pfam match to entry PF01138 RNase_PH, Prokaryotic ribonuclease PH; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score, so not added to product function. Functional classification - RNA synthesis, RNA modification and DNA transcription; PMID:16079137, PMID:2432069, PMID:10931296; polynucleotide phosphorylase 1185753 pnp 905544 pnp Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 polynucleotide phosphorylase YP_002344644.1 1183594 D 192222 CDS YP_002344645.1 218562866 905545 1185750..1186232 1 NC_002163.1 Original (2000) note: Cj1254, unknown, len: 160 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins and also to G/U mismatch-specific DNA glycosyl from other bacteria. Functional classification - Unknown; hypothetical protein 1186232 905545 Cj1254 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344645.1 1185750 D 192222 CDS YP_002344646.1 218562867 905546 1186290..1186499 1 NC_002163.1 Original (2000) note: Cj1255, possible isomerase,len: 69 aa; highly similar to hypothetical protein from Erwinia chrysanthemi YKDK_ERWCH in KDGK (pectin degradation) 5'region (73 aa), fasta scores; opt: 259 z-score: 374.4 E(): 1.5e-13, 61.2% identity in 67 aa overlap. Some similarity to plasmid-borne isomerases involed in toluene degradation e.g. XYLH_PSEPU 4-oxalocrotonate tautomerase (62 aa), fasta scores; opt: 104 z-score: 164.7 E(): 0.071, 30.8% identity in 65 aa overlap, and to chromosomal hypothetical proteins e.g. YDCE_ECOLI (77 aa), fasta scores; opt: 84 z-score: 136.1 E(): 2.8, 27.8% identity in 54 aa overlap. 64.2% identity to HP0924. Also similar to Cj0270 (37.7% identity in 69 aa overlap); Updated (2006) note: Pfam domain PF01361 Tautomerase enzyme identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score identified. kept within product function. Functional classification - Misc; isomerase 1186499 905546 Cj1255 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 isomerase YP_002344646.1 1186290 D 192222 CDS YP_002344647.1 218562868 905547 complement(1186496..1187158) 1 NC_002163.1 Original (2000) note: Cj1256c, possible membrane protein, len: 220 aa; no Hp match. Contains possible membrane spanning domain at N-terminus. Functional classification - Membranes, lipoproteins and porins; hypothetical protein 1187158 905547 Cj1256c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344647.1 1186496 R 192222 CDS YP_002344648.1 218562869 905548 complement(1187176..1188360) 1 NC_002163.1 Original (2000) note: Cj1257c, possible efflux pump, len: 394 aa; similar to TR:CAA07482 (EMBL:AJ007367) Streptococcus pneumoniae multi-drug resistance efflux pump pmrA (399 aa), fasta scores; opt: 854 z-score: 1007.9 E(): 0, 37.6% identity in 380 aa overlap. Also similar hypothetical transporters e.g. YCEE_ECOLI (408 aa), fasta scores; opt: 830 z-score: 965.7 E(): 0, 35.8% identity in 383 aa overlap, and to other members of the major facilitator family, e.g. BMR1_BACSU multidrug resistance protein 1 (389 aa), fasta scores; opt: 345 z-score: 405.2 E(): 2.8e-15, 24.2% identity in 389 aa overlap. No Hp match. Contains Pfam match to entry PF00083 sugar_tr,Sugar (and other) transporters; Updated (2006) note: Pfam domain PF07690 Major Facilitator Superfamily identified within CDS. Also,twelve probable transmembrane helices predicted by TMHMM2.0. Further support given to function. Some characterisation within Escherichia coli. Literature search identified paper giving further clues to product function (PMID:16048946). Functional classification -Drug/analogue sensitivity; PMID:1537791, PMID:11566977, PMID:16048946; efflux pump 1188360 905548 Cj1257c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 efflux pump YP_002344648.1 1187176 R 192222 CDS YP_002344649.1 218562870 905549 1188414..1188869 1 NC_002163.1 Original (2000) note: Cj1258, possible phosphotyrosine protein phosphatase, len: 151 aa; simlar to e.g. PPAL_YEAST low molecular weight phosphotyrosine protein phosphatase (EC 3.1.3.48) (161 aa), fasta scores; opt: 279 z-score: 343.4 E(): 7.9e-12, 37.6% identity in 149 aa overlap, and YWLE_BACSU low molecular weight protein-tyrosine protein phosphatase (150 aa),fasta scores; opt: 191 z-score: 240.4 E(): 4.3e-06, 27.7% identity in 148 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF01451 Low molecular weight phosphotyrosine protein identified within CDS. Further support given to pututive function. Possible changed to . Specific characterisation with acceptable identity score not carried out yet, so kept in product function. Functional classification -Protein translation and modification; phosphotyrosine protein phosphatase 1188869 905549 Cj1258 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphotyrosine protein phosphatase YP_002344649.1 1188414 D 192222 CDS YP_002344650.1 218562871 905550 1189121..1190395 1 NC_002163.1 Original (2000) note: Cj1259, porA, major outer membrane protein (MOMP), len: 424 aa; 94.6% identical to TR:AAC82317 (EMBL:U96452) C. jejuni major outer membrane porin (424 aa), and 98.0% identity to MOMP_CAMJE major outer membrane protein (fragments) (399 aa). No hp match. Also simlar in part to Cj1021c (63 aa, 34.5% identity in 55 aa overlap); Updated (2006) note: Pfam domain PF05538 Campylobacter major outer membrane protein identified within CDS. Further support given to product function. Characterised within Campylobacter jejuni, so not added to product function. Functional classification -Membranes, lipoproteins and porins; PMID:7543469, PMID:9163918; major outer membrane protein 1190395 porA 905550 porA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 major outer membrane protein YP_002344650.1 1189121 D 192222 CDS YP_002344651.1 218562872 905551 complement(1190510..1191631) 1 NC_002163.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 1191631 dnaJ 905551 dnaJ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molecular chaperone DnaJ YP_002344651.1 1190510 R 192222 CDS YP_002344652.1 218562873 905552 1191788..1192459 1 NC_002163.1 Original (2000) note: Cj1261, racR, two-component regulator, len: 223 aa; identical to TR:O68795 (EMBL:AF053960) C. jejuni response regulator protein (223 aa), and similar to e.g. BAER_ECOLI transcriptional regulatory protein BAER (240 aa), fasta scores; opt: 485 z-score: 583.5 E(): 3.3e-25, 37.4% identity in 219 aa overlap. 52.0% identity to HP0166. Also simlar to Cj1227c (50.7% identity in 223 aa overlap). Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain, and Pfam match to entry PF00486 trans_reg_C,Transcriptional regulatory protein, C terminal; Updated (2006) note: Characterisation work carried out in Campylobacter jejuni, so not added to product function. Literature search identified paper linking product function to be involved in virulence associated factors (PMID:16392901). Functional classification - Signal transduction; PMID:10322038, PMID:16392901; two-component regulator 1192459 racR 905552 racR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 two-component regulator YP_002344652.1 1191788 D 192222 CDS YP_002344653.1 218562874 905553 1192456..1193691 1 NC_002163.1 Original (2000) note: Cj1262, racS, probable two-component sensor (histidine kinase), len: 411 aa; 99.5% identical to TR:O68796 (EMBL:AF053961) C. jejuni histidine protein kinase (fragment) (189 aa), and similar to e.g. ENVZ_ECOLI osmolarity sensor protein ENVZ (450 aa), fast scores; opt: 188 z-score: 217.1 E(): 8.5e-05, 24.4% identity in 242 aa overlap. N-term has 28.2% identity to HP0165, C-term has 37.9% identity to HP0164. Also similar to Cj1226c (31.3% identity in 412 aa overlap). Contains Pfam match to entry PF00512 signal,Signal carboxyl-terminal domain, and Pfam match to entry PF00149 STphosphatase, Ser/Thr protein phosphatases; Updated (2006) note: Characterisation work carried out in Campylobacter jejuni, so not added to product function. Functional classification - Signal transduction; PMID:10322038; two-component sensor histidine kinase 1193691 racS 905553 racS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 two-component sensor histidine kinase YP_002344653.1 1192456 D 192222 CDS YP_002344654.1 218562875 905554 1193691..1194263 1 NC_002163.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1194263 recR 905554 recR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 recombination protein RecR YP_002344654.1 1193691 D 192222 CDS YP_002344655.1 218562876 905555 complement(1194260..1194796) 1 NC_002163.1 Original (2000) note: Cj1264c, hydD, probable hydrogenase maturation protease, len: 178 aa; simlar to e.g. HYDD_WOLSU HYDD protein (159 aa), fasta scores; opt: 443 z-score: 561.5 E(): 5.6e-24, 42.5% identity in 160 aa overlap, and HYBD_ECOLI hydrogenase 2 maturation protease (164 aa), fasta scores; opt: 212 z-score: 275.6 E(): 4.7e-08, 28.1% identity in 128 aa overlap. 42.7% identity to HP0634; Updated (2006) note: Pfam domain PF01750 Hydrogenase maturation protease identified within CDS. Further support given to product function. Some characterisation work within Wolinella succinogenes and Escherichia coli to different designations. kept within product function. Functional classification -Energy metabolism - Respiration; PMID:1587288, PMID:2180913, PMID:14726233; hydrogenase maturation protease 1194796 hydD 905555 hydD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hydrogenase maturation protease YP_002344655.1 1194260 R 192222 CDS YP_002344656.1 218562877 905556 complement(1194793..1195485) 1 NC_002163.1 Original (2000) note: Cj1265c, hydC, probable Ni/Fe-hydrogenase B-type cytochrome subunit, len: 230 aa; similar to e.g. CYBH_WOLSU quinone-reactive Ni/Fe-hydrogenase B-type cytochrome subunit (230 aa),fasta scores; opt: 771 z-score: 968.2 E(): 0, 49.8% identity in 225 aa overlap, and CYBH_ECOLI probable Ni/Fe-hydrogenase B-type cytochrome subunit (235 aa),fasta scores; opt: 344 z-score: 437.4 E(): 4.6e-17, 25.5% identity in 231 aa overlap. 41.1% identity to HP0633. Contains PS00883 Nickel-dependent hydrogenases b-type cytochrome subunit signature 2, and fam match to entry PF01292 Ni_hydr_CYTB, Nickel-dependent hydrogenases b-type cytochrome subunit; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. Characterised within Wolinella succinogenes with acceptable identity score, so not added to product function. Functional classification - Energy metabolism - Respiration; PMID:10525739, PMID:1587288, PMID:2180913; Ni/Fe-hydrogenase B-type cytochrome subunit 1195485 hydC 905556 hydC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Ni/Fe-hydrogenase B-type cytochrome subunit YP_002344656.1 1194793 R 192222 CDS YP_002344657.1 218562878 905557 complement(1195496..1197211) 1 NC_002163.1 Original (2000) note: Cj1266c, hydB, probable Ni/Fe-hydrogenase large subunit, len: 571 aa; similar to e.g. MBHL_WOLSU quinone-reactive Ni/Fe-hydrogenase large chain (575 aa), fasta scores; opt: 2619 z-score: 3068.8 E(): 0, 65.3% identity in 567 aa overlap, and MBHM_ECOLI hydrogenase-2 large chain (567 aa), fasta scores; opt: 1355 z-score: 1587.5 E(): 0, 42.1% identity in 589 aa overlap. 64.7% identity to HP0632. Contains PS00507 and PS00508 Nickel-dependent hydrogenases large subunit signatures 1 and 2, and Pfam match to entry PF00374 NiFeSe_Hases, Nickel-dependent hydrogenases; Updated (2006) note: Characterised within Wolinella succinogenes, so not added to product function. Functional classification - Energy metabolism -Respiration; PMID:10525739, PMID:1587288, PMID:2180913; Ni/Fe-hydrogenase large subunit 1197211 hydB 905557 hydB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Ni/Fe-hydrogenase large subunit YP_002344657.1 1195496 R 192222 CDS YP_002344658.1 218562879 905558 complement(1197214..1198353) 1 NC_002163.1 Original (2000) note: Cj1267c, hydA, probable Ni/Fe-hydrogenase small subunit, len: 379 aa; similar to e.g. MBHS_WOLSU quinone-reactive Ni/Fe-hydrogenase small chain precursor (354 aa), fasta scores; opt: 1968 z-score: 2288.8 E(): 0, 78.1% identity in 351 aa overlap, and MBHS_ECOLI hydrogenase-1 small chain precursor (372 aa),fasta scores; opt: 1058 z-score: 1232.4 E(): 0, 44.0% identity in 361 aa overlap. 68.2% identity to HP0631. Also similar to Cj1399c (50.8% identity in 329 aa overlap); Updated (2006) note: Pfam domain PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit identified within CDS. Further support given to product function. Characterised within Wolinella succinogenes, so not added to product function. Functional classification -Energy metabolism - Respiration; PMID:10525739, PMID:1587288, PMID:2180913; Ni/Fe-hydrogenase small chain 1198353 hydA 905558 hydA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Ni/Fe-hydrogenase small chain YP_002344658.1 1197214 R 192222 CDS YP_002344659.1 218562880 905559 complement(1198474..1200315) 1 NC_002163.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 1200315 mnmC 905559 mnmC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 5-methylaminomethyl-2-thiouridine methyltransferase YP_002344659.1 1198474 R 192222 CDS YP_002344660.1 218562881 905560 complement(1200312..1202291) 1 NC_002163.1 Original (2000) note: Cj1269c, amiA, probable N-acetylmuramoyl-L-alanine amidase, len: 659 aa; similar in N-terminus to many e.g. AMIA_ECOLI probable N-acetylmuramoyl-L-alanine amidase AMIA precursor (EC 3.5.1.28) (289 aa), fasta scores; opt: 393 z-score: 409.5 E(): 1.6e-15, 32.2% identity in 264 aa overlap, and CWLB_BACSU N-acetylmuramoyl-L-alanine amidase CWLB precursor (496 aa), fasta scores; opt: 250 z-score: 260.4 E(): 3.3e-07, 24.9% identity in 365 aa overlap. Similar in N-term to HP0772 (51.8% identity in 253 aa overlap). C-term approx 400 aa appear to be unique. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF01520 N-acetylmuramoyl-L-alanine amidase identified within CDS. Further support given to product function. Characterised in Escherchia coli with marginal identity score. Appropriate motifs present. not added to product function. Functional classification - Murein sacculus and peptidoglycan; PMID:12787347, PMID:6137479, PMID:11454209,PMID:12787347; N-acetylmuramoyl-L-alanine amidase 1202291 amiA 905560 amiA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 N-acetylmuramoyl-L-alanine amidase YP_002344660.1 1200312 R 192222 CDS YP_002344661.1 218562882 905561 complement(1202291..1203382) 1 NC_002163.1 Original (2000) note: Cj1270c, unknown, len: 363 aa; similar to hypothetical proteins e.g. TR:O66549 (EMBL:AE000676) Aquifex aeolicus AQ_159 (182 aa), fasta scores; opt: 550 z-score: 647.2 E(): 9.5e-29, 52.2% identity in 161 aa overlap. 61.1% identity to HP0773; Updated (2006) note: Pfam domain PF03060 2-nitropropane dioxygenase identified within CDS. Product function modified to more specific family member based on motif match. No specific characterisation has been carried out yet, so kept within product function. Functional classification - Misc; 2-nitropropane dioxygenase,oxidoreductase 1203382 905561 Cj1270c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 2-nitropropane dioxygenase,oxidoreductase YP_002344661.1 1202291 R 192222 CDS YP_002344662.1 218562883 905562 complement(1203379..1204584) 1 NC_002163.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1204584 tyrS 905562 tyrS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tyrosyl-tRNA synthetase YP_002344662.1 1203379 R 192222 CDS YP_002344663.1 218562884 905563 complement(1204596..1206791) 1 NC_002163.1 Original (2000) note: Cj1272c, spoT, probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase,len: 731 aa; similar to e.g. SPOT_ECOLI guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) (702 aa), fasta scores; opt: 1208 z-score: 1408.2 E(): 0, 32.8% identity in 677 aa overlap. 40.7% identity to HP0775. Also similar to e.g. RELA_ECOLI GTP pyrophosphokinase (744 aa), fasta scores; opt: 855 z-score: 995.9 E(): 0, 28.3% identity in 668 aa overlap. There appears to be no distinct relA homolog in Cj or Hp; Updated (2006) note: Pfam domains PF01842 ACT domain, PF02824 TGS domain, PF04607 Region found in RelA / SpoT proteins and PF01966 HD domain were all identified within CDS. Further support given to product function. Still not specifically characterised with acceptable identity score, so kept within product function. Literature search identified paper giving further clues to product function. Functional classification - Broad regulatory functions; PMID:15773975, PMID:2549050; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 1206791 spoT 905563 spoT Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase YP_002344663.1 1204596 R 192222 CDS YP_002344664.1 218562885 905564 complement(1206775..1206999) 1 NC_002163.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1206999 rpoZ 905564 rpoZ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA-directed RNA polymerase subunit omega YP_002344664.1 1206775 R 192222 CDS YP_002344665.1 218562886 905565 complement(1207010..1207729) 1 NC_002163.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 1207729 pyrH 905565 pyrH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 uridylate kinase YP_002344665.1 1207010 R 192222 CDS YP_002344666.1 218562887 905566 complement(1207781..1208974) 1 NC_002163.1 Original (2000) note: Cj1275c, probable periplasmic protein, len: 397 aa; weak similarity to hypothetical proteins e.g. YIBP_ECOLI (419 aa), fasta scores; opt: 203 z-score: 198.7 E(): 0.0009, 21.5% identity in 396 aa overlap. 36.4% identity to HP0750. Contains probable N-terminal signal sequence and coiled-coil regions between approx. aa 30-100 and 165-230; Updated (2006) note: Pfam domain PF01551 Peptidase family M23 identified within CDS. Also, one probable transmembrane helix predicted by TMHMM2.0. Product modified to more specific family member based on motif match. No specific characterisation has been carried out yet, so kept within product function. Functional classification - Degradation of macromolecules - Proteins,peptides and glycopeptides. Functional classification -Degradation of macromolecules - Proteins, peptides and glycopeptides; peptidase M23 family protein 1208974 905566 Cj1275c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptidase M23 family protein YP_002344666.1 1207781 R 192222 CDS YP_002344667.1 218562888 905567 complement(1208971..1209777) 1 NC_002163.1 Original (2000) note: Cj1276c, probable integral membrane protein, len: 268 aa; 32.1% identity to HP0749; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 1209777 905567 Cj1276c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344667.1 1208971 R 192222 CDS YP_002344668.1 218562889 905568 complement(1209764..1210429) 1 NC_002163.1 Original (2000) note: Cj1277c, probable ABC transporter ATP-binding protein, len: 221 aa; similar to many e.g. YCFV_ECOLI hypothetical ABC transporter ATP-binding protein (233 aa), fast scores; opt: 464 z-score: 566.5 E(): 2.9e-24, 38.2% identity in 220 aa overlap, and FTSE_ECOLI cell division ATP-binding protein FTSE (222 aa), fasta scores; opt: 455 z-score: 556.0 E(): 1.1e-23, 38.5% identity in 213 aa overlap. 54.8% identity to HP0748. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran, ABC transporters; Updated (2006) note: Similar to more than one characterised strain/genus. Literature search added for further information. kept within product function. Functional classification - Transport/binding proteins - Other; PMID:11844772, PMID:10783239, PMID:12823819; ABC transporter ATP-binding protein 1210429 905568 Cj1277c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter ATP-binding protein YP_002344668.1 1209764 R 192222 CDS YP_002344669.1 218562890 905569 complement(1210499..1211677) 1 NC_002163.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 1211677 trmB 905569 trmB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tRNA (guanine-N(7)-)-methyltransferase YP_002344669.1 1210499 R 192222 CDS YP_002344670.1 218562891 905570 complement(1211677..1212912) 1 NC_002163.1 Original (2000) note: Cj1279c, probable fibronectin domain-containing lipoprotein, len: 411 aa; 31.1% identity to HP0746. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains 4x Pfam match to entry PF00041 fn3, Fibronectin type III domain; Updated (2006) note: Specific characterisation with acceptable identity score has not been carried out yet, so kept within product function. Functional classification - Pathogenicity; fibronectin domain-containing lipoprotein 1212912 905570 Cj1279c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 fibronectin domain-containing lipoprotein YP_002344670.1 1211677 R 192222 CDS YP_002344671.1 218562892 905571 complement(1212857..1213825) 1 NC_002163.1 Original (2000) note: Cj1280c, probable ribosomal pseudouridine synthase, len: 322 aa; similar to e.g. RLUD_ZYMMO ribosomal large subunit pseudouridine synthase D (EC 4.2.1.70) (317 aa), fasta scores; opt: 508 z-score: 590.1 E(): 1.4e-25, 33.5% identity in 310 aa overlap. 51.4% identity to HP0745. Also similar to Cj0708 (26.9% identity in 223 aa overlap), and Cj0022c (31.7% identity in 246 aa overlap). Contains PS01129 Hypothetical yabO/yceC/sfhB family signature, and Pfam match to entry PF00849 YABO, Hypothetical yabO/yceC/sfhB family; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet, so kept within product function. Functional classification - Ribosomal protein synthesis and modification; ribosomal pseudouridine synthase 1213825 905571 Cj1280c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribosomal pseudouridine synthase YP_002344671.1 1212857 R 192222 CDS YP_002344672.1 218562893 905572 1213903..1215003 1 NC_002163.1 Original (2000) note: Cj1282, mrdB, probable RodA protein homolog, len: 366 aa; similar to e.g. RODA_ECOLI rod shape-determining protein RODA (370 aa), fasta scores; opt: 699 z-score: 837.9 E(): 0, 35.8% identity in 355 aa overlap, and SP5E_BACSU stage V sporulation protein E (366 aa), fasta scores; opt: 526 z-score: 632.0 E(): 6.6e-28,30.3% identity in 337 aa overlap. 52.8% identity to HP0743. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein; Updated (2006) note: Nine probable transmembrane helices predicted by TMHMM2.0. Homolog designation kept within product function. Functional classification -Murein sacculus and peptidoglycan; PMID:6243629; RodA protein 1215003 mrdB 905572 mrdB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 RodA protein YP_002344672.1 1213903 D 192222 CDS YP_002344673.1 218562894 905575 1215456..1216799 1 NC_002163.1 Original (2000) note: Cj1283, ktrB, probable K+ uptake protein, len: 447 aa; similar to e.g. TR:O87953 (EMBL:D89592) Vibrio alginolyticus K+-uptake system KTRB protein (455 aa), fasta scores; opt: 844 z-score: 981.2 E(): 0, 33.8% identity in 438 aa overlap. Also similar to NTPJ_ENTHR V-type sodium ATP synthase subunit J (451 aa),fasta scores; opt: 853 z-score: 991.7 E(): 0, 33.3% identity in 447 aa overlap, and TRKH_ECOLI TRK system potassium uptake protein TRKH (483 aa), fasta scores; opt: 210 z-score: 247.5 E(): 1.7e-06, 26.8% identity in 426 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02386 Cation transport protein domain identified within CDS. Also,eleven probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. No specific characterisation with acceptable identity score yet, so kept within product function. Functional classification - Transport/binding proteins - Cations; PMID:16210320, PMID:12562800, PMID:9642210; K+ uptake protein 1216799 ktrB 905575 ktrB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 K+ uptake protein YP_002344673.1 1215456 D 192222 CDS YP_002344674.1 218562895 905576 1216810..1217460 1 NC_002163.1 Original (2000) note: Cj1284, ktrA, probable K+ uptake protein, len: 216 aa; similar to e.g. TR:O87952 (EMBL:D89592) Vibrio alginolyticus K+-uptake system KTRA protein (220 aa), fasta scores; opt: 316 z-score: 371.1 E(): 2.3e-13, 29.2% identity in 212 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF02254 TrkA-N domain and PF02080 TrkA-C domain identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score yet, so kept within product function. Functional classification - Transport/binding proteins - Cations; PMID:16210320, PMID:12562800, PMID:9642210; K+ uptake protein 1217460 ktrA 905576 ktrA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 K+ uptake protein YP_002344674.1 1216810 D 192222 CDS YP_002344675.1 218562896 905577 complement(1217457..1218128) 1 NC_002163.1 Original (2000) note: Cj1285c, unknown, len: 223 aa; similar to hypothetical proteins e.g. TR:O29858 (EMBL:AE001077) Archaeoglobus fulgidus AF0389 (249 aa),fasta scores; opt: 120 z-score: 148.0 E(): 0.61, 23.7% identity in 257 aa overlap. 46.8% identity to HP0778; Updated (2006) note: Pfam domains PF02621 Uncharacterized ACR, COG1427 identified within CDS. Conserved added to product funtion. Functional classification - Conserved hypothetical proteins; hypothetical protein 1218128 905577 Cj1285c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344675.1 1217457 R 192222 CDS YP_002344676.1 218562897 905578 complement(1218134..1218760) 1 NC_002163.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 1218760 upp 905578 upp Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 uracil phosphoribosyltransferase YP_002344676.1 1218134 R 192222 CDS YP_002344677.1 218562898 905579 complement(1218757..1219992) 1 NC_002163.1 Original (2000) note: Cj1287c, probable malate oxidoreductase, len: 411 aa; highly similar to many e.g. MAOX_BACST malate oxidoreductase (NAD) (EC 1.1.1.38) (478 aa), fasta scores; opt: 1193 z-score: 1304.5 E(): 0, 49.9% identity in 411 aa overlap. No Hp match. Contains Pfam match to entry PF00390 malic, Malic enzymes; Updated (2006) note: Characterised in more than one genus with acceptable identity scores, so not added to product function. Functional classification -Central intermediary metabolism - Gluconeogenesis; PMID:1371255, PMID:7798145, PMID:9535928,PMID:36376; malate oxidoreductase 1219992 905579 Cj1287c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 malate oxidoreductase YP_002344677.1 1218757 R 192222 CDS YP_002344678.1 218562899 905580 complement(1219994..1221385) 1 NC_002163.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 1221385 gltX 905580 gltX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glutamyl-tRNA synthetase YP_002344678.1 1219994 R 192222 CDS YP_002344679.1 218562900 905581 1221450..1222265 1 NC_002163.1 Original (2000) note: Cj1289, possible periplasmic protein, len: 271 aa; 25.8% identity to C-terminus of HP0659. Contains possible N-terminal signal sequence. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 1222265 905581 Cj1289 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344679.1 1221450 D 192222 CDS YP_002344680.1 218562901 905582 complement(1222303..1223634) 1 NC_002163.1 biotin carboxylase; biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA; catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; biotin carboxylase 1223634 accC 905582 accC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 biotin carboxylase YP_002344680.1 1222303 R 192222 CDS YP_002344681.1 218562902 905583 complement(1223636..1224091) 1 NC_002163.1 Original (2000) note: Cj1291c, accB, probable biotin carboxyl carrier protein of acetyl-CoA carboxylase,len: 151 aa; similar to e.g. BCCP_ECOLI biotin carboxyl carrier protein of acetyl-CoA carboxylase (EC 6.4.1.2) (156 aa), fasta scores; opt: 307 z-score: 329.6 E(): 4.6e-11, 38.9% identity in 162 aa overlap. 41.4% identity to HP0371. Contains Pfam match to entry PF00364 biotin_req_enzy, Biotin-requiring enzymes; Updated (2006) note: Some characterisation work carried out within Bacillus subtilis. kept within product function. Functional classification - Fatty acid biosynthesis; PMID:7592499, PMID:1358874; biotin carboxyl carrier protein of acetyl-CoA carboxylase 1224091 accB 905583 accB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 biotin carboxyl carrier protein of acetyl-CoA carboxylase YP_002344681.1 1223636 R 192222 CDS YP_002344682.1 218562903 905584 1224239..1224799 1 NC_002163.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1224799 dcd 905584 dcd Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 deoxycytidine triphosphate deaminase YP_002344682.1 1224239 D 192222 CDS YP_002344683.1 218562904 905585 1224849..1225853 1 NC_002163.1 Original (2000) note: Cj1293, possible sugar nucleotide epimerase/dehydratase, len: 334 aa; similar to many e..g TR:Q45984 (EMBL:U27301) Caulobacter crescentus FLAA1 protein (331 aa), fasta scores; opt: 1240 z-score: 1410.9 E(): 0, 57.8% identity in 329 aa overlap,CAPD_STAAU CAPD protein (599 aa), fasta scores; opt: 529 z-score: 602.6 E(): 2.9e-26, 33.9% identity in 319 aa overlap, and TR:O69130 (EMBL:AF064070) Burkholderia pseudomallei epimerase/dehydratase WBII (637 aa),fasta scores; opt: 433 z-score: 493.6 E(): 3.4e-20, 30.5% identity in 282 aa overlap. 64.6% identity to HP0840. Contains PS00017 ATP/GTP-binding site motif A (P-loop; Updated (2006) note: Pfam domain PF02719 Polysaccharide biosynthesis protein identified within CDS. Further support given to product function. Characterised within Campylobacter jejuni. Product function modified to more specific family member. Cj1293 is involved in flagellin glycosylation and has USP-GlcNAc C(6) dehydratase activity. This enzyme catalyzes the first step in the biosynthesis of bacillosamine, a sugar found in Campylobacter jejuni glycosylation motifs (PMID:14960321). Recently, Cj1293 enzyme was found to exhibit C6 dehydratase as well as a newly identified C5 epimerase activity that resulted in the production of UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose (PMID:16286454). Plays a direct role in CMP-Pse5NAc7NAc or CMP-Pse5NAc7Am pathyways. Logan (Susan.Logan@nrc-cnrc.gc.ca) personal communication. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Surface structures; PMID:16421095, PMID:16286454, PMID:14960321,PMID:14617187, PMID:16573682, PMID:12781527; UDP-GlcNAc-specific C4,6 dehydratase/C5 epimerase 1225853 pseB 905585 pseB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-GlcNAc-specific C4,6 dehydratase/C5 epimerase YP_002344683.1 1224849 D 192222 CDS YP_002344684.1 218562905 905586 1225855..1226985 1 NC_002163.1 Original (2000) note: Cj1294, probable aminotransferase, len: 376 aa; similar to many members of the degT family e.g. SPSC_BACSU spore coat polysaccharide biosynthesis protein (389 aa), fasta scores; opt: 586 z-score: 676.7 E(): 2.1e-30, 35.3% identity in 385 aa overlap, and TR:O88001 (EMBL:AJ007747) Bordetella bronchiseptica amino-sugar biosynthesis protein WLBC (366 aa), fasta scores; opt: 482 z-score: 558.1 E(): 8.7e-24, 28.8% identity in 330 aa overlap. 44.8% identity to HP0366 . Contains Pfam match to entry PF01041 DegT_DnrJ_EryC1, DegT/DnrJ/EryC1/StrS family; Updated (2006) note: Specific characterisation with acceptable identity scores has been carried out in Campylobacter jejuni, Product modified to more specific family. not added to product function. Cj1294 was demonstrated to be a pyridoxal phosphate-dependent aminotransferase specific for UDP-4-keto-6-deoxy-GlcNAc. These results indicate that Cj1294 is involved in the biosynthesis of diacetamidofucosamine, a C4 epimer of diacetamidobacillosamine not yet described in C. jejuni proteoglycans, suggesting that the composition of C. jejuni proteoglycans is more variable than anticipated (PMID:15790564). Recent work has demonstrated that Cj1294 utilize only UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose as substrate producing UDP-4-amino-4,6-dideoxy-beta-L-AltNAc,a precursor in the pseudaminic acid biosynthetic pathway (PMID:16286454). Plays a direct role in CMP-Pse5NAc7NAc or CMP-Pse5NAc7Am pathyways. Logan (Susan.Logan@nrc-cnrc.gc.ca) personal communication. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Surface structures; PMID:16421095, PMID:15790564, PMID:16286454,PMID:14960321, PMID:14617187, PMID:12704196,PMID:16573682, PMID:12781527; C4 aminotransferase 1226985 pseC 905586 pseC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 C4 aminotransferase YP_002344684.1 1225855 D 192222 CDS YP_002344685.1 218562906 905587 1226978..1228285 1 NC_002163.1 Original (2000) note: Cj1295, unknown, len: 435 aa; no Hp match; Updated (2006) note: PIR (Protein Information Resource) database has a match with IPR012353 Uncharacterised conserved protein, PIRSF01524 polysaccharide biosynthesis aminopeptidase-like protein. Members of this group from Streptomyces sp. and Brucella melitensis are encoded by polysaccharide biosynthesis gene clusters, and are believed to be involved in polysaccharide biosynthesis (PMID:12644223). Members of this group exhibit distant sequence similarity to aminopeptidases. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Unknown; PMID:12644223, PMID:16573682, PMID:12781527; hypothetical protein 1228285 905587 Cj1295 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344685.1 1226978 D 192222 CDS YP_002344686.1 218562907 905588 1228282..1228641 1 NC_002163.1 Original (2000) note: Cj1296, unknown, len: 119 aa; weak similarity to aminoglycoside N3'-acetyltransferases e.g. AAC3_PSEAE aminoglycoside N3'-acetyltransferase III (271 aa), fasta scores; opt: 102 z-score: 144.2 E(): 1,31.7% identity in 60 aa overlap. No Hp match. Similar to N-terminus of Cj1298 (65.7% identity in 105 aa overlap). Similarity continues in downstream ORF Cj1297. There is a G(9) tract at aa 104 that, if variable, would allow translation to continue into Cj1297; Updated (2006) note: Literature search identified paper linking product function of Cj1296/Cj1297/Cj1298 to antimicrobial efflux pumps. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Antibiotic resistance; PMID:16573682, PMID:12781527; hypothetical protein 1228641 905588 Cj1296 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344686.1 1228282 D 192222 CDS YP_002344687.1 218562908 905589 1228638..1229075 1 NC_002163.1 Original (2000) note: Cj1297, unknown, len: 145 aa; no Hp match. Similar to C-terminus of Cj1298 (44.7% identity in 141 aa overlap). Similarity continues from upstream gene Cj1296. There is a G(9) tract upstream of this start that, if variable, would allow translation from Cj1296; Updated (2006) note: Literature search identified paper linking product function of Cj1296/Cj1297/Cj1298 to antimicrobial efflux pumps. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Antibiotic resistance; PMID:16573682, PMID:12781527; hypothetical protein 1229075 905589 Cj1297 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344687.1 1228638 D 192222 CDS YP_002344688.1 218562909 905590 1229096..1229887 1 NC_002163.1 Original (2000) note: Cj1298, unknown, len: 263 aa; weak similarity to aminoglycoside N3'-acetyltransferases e.g. AAC4_SALSP aminoglycoside N3'-acetyltransferase IV (261 aa), fasta scores; opt: 139 z-score: 177.8 E(): 0.014, 25.7% identity in 175 aa overlap. Similar in N- and C-terminus to upstream ORFs Cj1296 (65.7% identity in 105 aa overlap), and Cj1297 (44.7% identity in 141 aa overlap). No Hp match. There is a G(9) tract that, if variable, would allow fusion of Cj1296 and Cj1297. There is no equivalent repetitive tract in this CDS; Updated (2006) note: Literature search identified paper linking product function of Cj1296/Cj1297/Cj1298 to antimicrobial efflux pumps. Some characterisation work within Campylobacter jejuni. Product function modified to more specific family member. kept within product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Surface structures; PMID:15790564, PMID:16573682, PMID:12781527; N-acetyltransferase 1229887 905590 Cj1298 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 N-acetyltransferase YP_002344688.1 1229096 D 192222 CDS YP_002344689.1 218562910 905591 1229918..1230148 1 NC_002163.1 Original (2000) note: Cj1299, acpP2, probable acyl carrier protein, len: 76 aa; similar to many e.g. ACPH_MYCGE acyl carrier protein homolog (84 aa), fasta scores; opt: 111 z-score: 172.6 E(): 0.026, 35.8% identity in 81 aa overlap. No Hp match. Also similar to acpP Cj0441 (34.1% identity in 41 aa overlap); Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. kept within product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Fatty acid biosynthesis; PMID:16573682, PMID:12781527; acyl carrier protein 1230148 acpP2 905591 acpP2 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acyl carrier protein YP_002344689.1 1229918 D 192222 CDS YP_002344690.1 218562911 905592 1230145..1231038 1 NC_002163.1 Original (2000) note: Cj1300, unknown, len: 297 aa; no Hp match; Updated (2006) note: Prosite domains PS50193 SAM_BIND, SAM (and some other nucleotide) binding motif and PS50124 MET_TRANS, Generic methyltransferase were both identified within CDS. Product modified to more specific family member based on motif results. Specific characterisation has not been carried out yet. kept within product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Misc; PMID:16573682, PMID:12781527; SAM domain containing methyltransferase 1231038 905592 Cj1300 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 SAM domain containing methyltransferase YP_002344690.1 1230145 D 192222 CDS YP_002344691.1 218562912 905593 1231031..1231447 1 NC_002163.1 Original (2000) note: Cj1301, unknown, len: 138 aa; similar to a hypothetical protein from Pyrococcus horikoshii TR:O58010 (EMBL:AP000001) PH0272 (136 aa),fasta scores; opt: 137 z-score: 188.8 E(): 0.0032, 32.8% identity in 137 aa overlap. No Hp match; Updated (2006) note: Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Conserved hypothetical proteins; PMID:16573682, PMID:12781527; hypothetical protein 1231447 905593 Cj1301 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344691.1 1231031 D 192222 CDS YP_002344692.1 218562913 905594 1231444..1233006 1 NC_002163.1 Original (2000) note: Cj1302, unknown, len: 520 aa; no Hp match; Updated (2006) note: TIGRFAM domain TIGR01681 HAD-SF-IIIC, HAD-superfamily phosphatase subfamily IIIC identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation with acceptable identity score carried out yet, so kept within product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Misc; PMID:16573682, PMID:12781527; HAD-superfamily hydrolase 1233006 905594 Cj1302 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 HAD-superfamily hydrolase YP_002344692.1 1231444 D 192222 CDS YP_002344693.1 218562914 905595 1232996..1234057 1 NC_002163.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; paralogs which do not contain the N-X-R ACP-binding site motif; 3-oxoacyl-ACP synthase 1234057 fabH2 905595 fabH2 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 3-oxoacyl-ACP synthase YP_002344693.1 1232996 D 192222 CDS YP_002344694.1 218562915 905596 1234057..1234278 1 NC_002163.1 Original (2000) note: Cj1304, acpP3, probable acyl carrier protein, len: 73 aa; similar to e.g. CP_MYXXA acyl carrier protein (78 aa), fasta scores; opt: 101 z-score: 157.0 E(): 0.19, 28.4% identity in 74 aa overlap. No Hp match. Also similar to acpP2 Cj1299 (25.4% identity in 63 aa overlap); Updated (2006) note: No specific charactersiation with acceptable identity score has been carried out yet,so kept within product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Fatty acid biosynthesis; PMID:16573682, PMID:12781527; acyl carrier protein 1234278 acpP3 905596 acpP3 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acyl carrier protein YP_002344694.1 1234057 D 192222 CDS YP_002344695.1 218562916 905597 complement(1234292..1235509) 1 NC_002163.1 Original (2000) note: Cj1305c, unknown, len: 405 aa; no Hp match. A member of the 617 family of C.j. proteins containing homopolymeric tracts; similar to Cj0617/Cj0618 (38.9% identity in 180 aa overlap/37.1% identity in 221 aa overlap), Cj1306c (78.1% identity in 407 aa overlap), Cj1310c (63.7% identity in 402 aa overlap), Cj1342c (38.0% identity in 426 aa overlap). Contains a variable polyG-tract at aa 194; G(9) (consensus) gives this ORF, G(10) would cause truncation after 22 aa; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Unknown; PMID:16573682, PMID:12781527; hypothetical protein 1235509 905597 Cj1305c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344695.1 1234292 R 192222 CDS YP_002344696.1 218562917 905598 complement(1235522..1236748) 1 NC_002163.1 Original (2000) note: Cj1306c, unknown, len: 405 aa; no Hp match. A member of the 617 family of C.j. proteins containing homopolymeric tracts; similar to Cj1310c (59.8% identity in 410 aa overlap), Cj1305c (78.1% identity in 407 aa overlap), Cj1342c (38.5% identity in 426 aa overlap) and Cj0617/Cj0618 (39.2% identity in 181 aa overlap/39.5% identity in 220 aa overlap). Contains a variable polyG-tract at aa 194; G(9) (consensus) gives this ORF, G(8) would cause truncation after 5 aa; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Unknown; PMID:16573682, PMID:12781527; hypothetical protein 1236748 905598 Cj1306c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344696.1 1235522 R 192222 CDS YP_002344697.1 218562918 905599 1236809..1238317 1 NC_002163.1 Original (2000) note: Cj1307, possible amino acid activating enzyme, len: 502 aa; similar to e.g. DLTA_BACSU D-alanine-activating enzyme (EC 6.3.2.-) (503 aa), fasta scores; opt: 726 z-score: 837.7 E(): 0, 30.3% identity in 495 aa overlap, and to parts of ENTF_ECOLI enterobactin synthetase component F (1293 aa), fasta scores; opt: 549 z-score: 627.8 E(): 1.1e-27, 27.4% identity in 460 aa overlap, and GRSB_BACBR gramicidin S synthetase II (4451 aa), fasta scores; opt: 571 z-score: 644.7 E(): 1.3e-28,29.9% identity in 508 aa overlap. No Hp match. Contains PS00455 AMP-binding domain signature, and Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Updated (2006) note: Similar to many different designations, however, no specific characterisation with acceptable identity score carried out yet. kept within product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Cell envelope; PMID:7797557, PMID:16573682, PMID:12781527; amino acid activating enzyme 1238317 905599 Cj1307 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amino acid activating enzyme YP_002344697.1 1236809 D 192222 CDS YP_002344698.1 218562919 905600 1238357..1238584 1 NC_002163.1 Original (2000) note: Cj1308, acpP4, possible acyl carrier protein, len: 75 aa; some similartiy to e.g. ACP_CYAPA acyl carrier protein (103 aa), fasta scores; opt: 84 z-score: 126.5 E(): 9.5, 31.3% identity in 64 aa overlap. No Hp match; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. kept within product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Fatty acid biosynthesis; PMID:7797557, PMID:16573682, PMID:12781527; acyl carrier protein 1238584 905600 Cj1308 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acyl carrier protein YP_002344698.1 1238357 D 192222 CDS YP_002344699.1 218562920 905601 complement(1238581..1239651) 1 NC_002163.1 Original (2000) note: Cj1309c, unknown, len 356 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Unknown; PMID:16573682, PMID:12781527; hypothetical protein 1239651 905601 Cj1309c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344699.1 1238581 R 192222 CDS YP_002344700.1 218562921 905602 complement(1239673..1240887) 1 NC_002163.1 Original (2000) note: Cj1310c, unknown, len: 404 aa; no Hp match. A member of the 617 family of C.j. proteins containing homopolymeric tracts; similar to Cj1305c (63.7% identity in 402 aa overlap), Cj1306c (59.8% identity in 410 aa overlap), Cj1342c (37.1% identity in 426 aa overlap) and Cj0617/Cj0618 (37.4% identity in 182 aa overlap/34.1% identity in 220 aa overlap). Contains a variable polyG-tract at aa 194; G(9) (consensus) gives this ORF, G(10) would cause truncation after 22 aa; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Unknown; PMID:16573682, PMID:12781527; hypothetical protein 1240887 905602 Cj1310c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344700.1 1239673 R 192222 CDS YP_002344701.1 218562922 905603 1240966..1241664 1 NC_002163.1 Original (2000) note: Cj1311, neuA2, probable acylneuraminate cytidylyltransferase (CMP-N-acetylneuraminic acid synthetase), len: 232 aa; simlar to e.g. NEUA_ECOLI acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthetase) (419 aa), fasta scores; opt: 316 z-score: 379.1 E(): 8.2e-14, 29.0% identity in 231 aa overlap. 39.6% identity to HP0326. Also similar to Cj1143 (31.6% identity in 215 aa overlap), and Cj1331 (32.9% identity in 234 aa overlap); Updated (2006) note: Pfam domain PF02348 Cytidylyltransferase identified within CDS. Further support given to product function. Characterised within Escherichia coli with marginal identity score. kept within product function. Recently designated within Campylobacter jejuni 81176 as pseF. Recent analysis work carried out in Campylobacter shows role in pseudaminic acid synthesis. PseF is thought to allow PseAc to form CMP-PseAc. Plays a direct role in CMP-Pse5NAc7NAc or CMP-Pse5NAc7Am pathyways. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:2549035, PMID:16573682, PMID:12781527; acylneuraminate cytidylyltransferase 1241664 pseF 905603 pseF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acylneuraminate cytidylyltransferase YP_002344701.1 1240966 D 192222 CDS YP_002344702.1 218562923 905604 1241648..1242472 1 NC_002163.1 Original (2000) note: Cj1312, possible flagellar protein, len: 274 aa; similar to e.g. SPSG_BACSU spore coat polysaccharide biosynthesis protein SPSG (222 aa),fasta scores; opt: 166 z-score: 208.1 E(): 0.00028, 24.8% identity in 226 aa overlap, and TR:Q45987 (EMBL:U27302) Caulobacter crescentus FLAR (329 aa), fasta scores; opt: 234 z-score: 286.7 E(): 1.2e-08, 23.1% identity in 277 aa overlap; Updated (2006) note: Characterised in Campylobacter jejuni (PMID:16728396). Product function further updated. not added to product function. Plays a direct role in CMP-Pse5NAc7NAc or CMP-Pse5NAc7Am pathyways. Logan (Susan.Logan@nrc-cnrc.gc.ca) personal communication. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Surface structures; PMID:16728396, PMID:16751642, PMID:16573682,PMID:12781527, PMID:16684771, PMID:16728396; nucleotidase specific for PseC product,UDP-4-amino-4,6-dideoxy-beta-L-AltNAc 1242472 pseG 905604 pseG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 nucleotidase specific for PseC product,UDP-4-amino-4,6-dideoxy-beta-L-AltNAc YP_002344702.1 1241648 D 192222 CDS YP_002344703.1 218562924 905605 1242469..1242942 1 NC_002163.1 Original (2000) note: Cj1313, possible flagellar protein, len: 157 aa; similar to e.g. TR:Q45990 (EMBL:U28867) Caulobacter crescentus FLAG. 31.9% identity to HP0327; Updated (2006) note: Pfam domain PF00583 Acetyltransferase (GNAT) family identified within CDS. Recent characterisation work in Campylobacter has linked this protein to be part of the biosynthetic pathway for pseudaminic acid and bacillosamine biosynthesis. In particular, PseH is thought to operate between UDP-6-deosy-beta-L-AltNAc4NAc to 6-deoxy-beta-L-AltNAc4NAc. Plays a direct role in CMP-Pse5NAc7NAc or CMP-Pse5NAc7Am pathyways. Logan (Susan.Logan@nrc-cnrc.gc.ca) personal communication. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Surface structures; PMID:16684771, PMID:16751642, PMID:9748431,PMID:16573682, PMID:12781527; N-acetyltransferase specific for PseC product,UDP-4-amino-4,6-dideoxy-beta-L-AltNAc 1242942 pseH 905605 pseH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 N-acetyltransferase specific for PseC product,UDP-4-amino-4,6-dideoxy-beta-L-AltNAc YP_002344703.1 1242469 D 192222 CDS YP_002344704.1 218562925 905606 complement(1242907..1243653) 1 NC_002163.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamide and glutamine to imidazole-glycerolphosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1243653 hisF 905606 hisF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 imidazole glycerol phosphate synthase subunit HisF YP_002344704.1 1242907 R 192222 CDS YP_002344705.1 218562926 905607 complement(1243654..1244259) 1 NC_002163.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1244259 hisH 905607 hisH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 imidazole glycerol phosphate synthase subunit HisH YP_002344705.1 1243654 R 192222 CDS YP_002344706.1 218562927 905608 complement(1244256..1245392) 1 NC_002163.1 Original (2000) note: Cj1316c, unknown, len: 378 aa; similar to e.g. TR:P72140 (EMBL:U50396) Pseudomonas aeruginosa WBPG (lipopolysaccharide gene cluster) (376 aa), fasta scores; opt: 257 z-score: 302.0 E(): 1.6e-09,23.5% identity in 366 aa overlap. No Hp match. Also similar to Cj1324 (33.2% identity in 373 aa overlap); Updated (2006) note: Prosite domain PS00761 SPASE_I_3, Peptidase S26A, signal peptidase I identified within CDS. Product function modified to more specific family member based on motif match. PseA has been proposed to play a role in the pseudaminic acid biosynthetic pathway by appearing to synthesize pseudaminic acid (PseAm) directly from PseAc by transfer of an acetamidino group (PMID:11461915). Plays a direct role in CMP-Pse5NAc7NAc or CMP-Pse5NAc7Am biosynthesis or transfer. Logan (Susan.Logan@nrc-cnrc.gc.ca) personal communication. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Surface structures; PMID:16573682, PMID:12781527, PMID:16684771; pseudaminic acid biosynthesis PseA protein 1245392 pseA 905608 pseA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 pseudaminic acid biosynthesis PseA protein YP_002344706.1 1244256 R 192222 CDS YP_002344707.1 218562928 905609 1245650..1246681 1 NC_002163.1 Original (2000) note: Cj1317, neuB3,N-acetylneuraminic acid synthetase, len: 343 aa; 97.6% identical to TR:O52907 (EMBL:AJ000855) C. jejuni neuB, and similar to e.g. TR:Q57265 (EMBL:U40740) Neisseria meningitidis N-acetylneuraminic acid synthetase (EC 4.1.3.-) (349 aa), fasta scores; opt: 584 z-score: 664.1 E(): 1.1e-29, 35.1% identity in 350 aa overlap. 49.5% identity to HP0178. Also similar to Cj1327 (36.3% identity in 336 aa overlap), and Cj1141 (34.7% identity in 340 aa overlap); Updated (2006) note: Pfam domain PF03102 NeuB family identified within CDS. Further support given to product function. Recent characterisation has shown PseI to be responsible for the conversion of 6-deoxy-beta-L-AltNAc4NAc to Pse5NAc7NAc in the pseudaminic acid biosynthesis pathway. Plays a direct role in CMP-Pse5NAc7NAc or CMP-Pse5NAc7Am pathyways. Logan (Susan.Logan@nrc-cnrc.gc.ca) personal communication. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Surface structures; PMID:11461915, PMID:16120604, PMID:10712693,PMID:11832511, PMID:16421095; Pse synthetase 1246681 pseI 905609 pseI Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Pse synthetase YP_002344707.1 1245650 D 192222 CDS YP_002344708.1 218562929 905610 1246678..1248627 1 NC_002163.1 Original (2000) note: Cj1318, unknown, len: 649 aa; no Hp ortholog, but 33.9% identity to HP0114. A member of the 1318 family of proteins. Similar to Cj1335/Cj1336 (100.0% identity in 59 aa overlap/100.0% identity in 592 aa overlap), Cj1333 (72.5% identity in 658 aa overlap),Cj1334 (41.5% identity in 648 aa overlap), Cj1337 (48.1% identity in 643 aa overlap), Cj1341c (30.2% identity in 640 aa overlap), Cj1340c (31.4% identity in 641 aa overlap). Contains G(10-11) polymorphic tract at aa 57. G(11) (consensus) gives this ORF, G(10) causes truncation after 1 aa; Updated (2006) note: Pfam domain PF01973 Protein of unknown function DUF115 identified within CDS. Characterisation work has been carried out within Campylobacter jejuni (PMID:11895937). Product function modified to more specific family member. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Misc; PMID:11895937, PMID:16573682, PMID:12781527; motility accessory factor 1248627 maf1 905610 maf1 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 motility accessory factor YP_002344708.1 1246678 D 192222 CDS YP_002344709.1 218562930 905611 1248624..1249595 1 NC_002163.1 Original (2000) note: Cj1319, probable nucleotide sugar dehydratase, len: 323 aa; similar to e.g. TR:Q54116 (EMBL:L37354) thymidine diphosphoglucose 4,6-dehydratase (329 aa), fasta scores; opt: 526 z-score: 600.3 E(): 3.9e-26, 29.5% identity in 315 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00106 adh_short,Alcohol/other dehydrogenases, short chain type; Updated (2006) note: Pfam domain now altered to PF01370 NAD dependent epimerase/dehydratase family. Further support given to product function. No specific characterisation with acceptable identity score carried out yet. kept within product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification -Surface polysaccharides, lipopolysaccharides and antigens; PMID:16573682, PMID:12781527; nucleotide sugar dehydratase 1249595 905611 Cj1319 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 nucleotide sugar dehydratase YP_002344709.1 1248624 D 192222 CDS YP_002344710.1 218562931 905612 1249588..1250742 1 NC_002163.1 Original (2000) note: Cj1320, probable aminotransferase, len: 384 aa; similar to members of the degT family e.g. TR:Q06953 (EMBL:X59554) Vibrio cholerae RFBE protein (367 aa), fasta scores; opt: 315 z-score: 377.4 E(): 1e-13, 32.7% identity in 361 aa overlap. No Hp ortholog. Contains Pfam match to entry PF01041 DegT_DnrJ_EryC1, DegT/DnrJ/EryC1/StrS family; Updated (2006) note: No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:16573682, PMID:12781527; DegT family aminotransferase 1250742 905612 Cj1320 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DegT family aminotransferase YP_002344710.1 1249588 D 192222 CDS YP_002344711.1 218562932 905613 1250852..1251394 1 NC_002163.1 Original (2000) note: Cj1321, probable transferase,len: 180 aa; similar to TR:Q46674 (EMBL:U05248) E. coli polysialic acid gene cluster region 2 neuD (207 aa), fasta scores; opt: 267 z-score: 337.2 E(): 1.8e-11, 29.6% identity in 162 aa overlap, some simialrity to e.g. LPXA_BRUAB acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (283 aa), fasta scores; opt: 134 z-score: 173.4 E(): 0.025, 31.6% identity in 95 aa overlap. No Hp match. Also similar to Cj1123c wlaI (30.2% identity in 179 aa overlap). Contains 2x Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats). Upstream region contains a G(10-11) hypervariable tract; Updated (2006) note: No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Literature search identified paper linking Cj1321-Cj1326 as being a glycosylation islet (PMID:16230626). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:16230626, PMID:11832511, PMID:16573682,PMID:12781527; transferase 1251394 905613 Cj1321 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transferase YP_002344711.1 1250852 D 192222 CDS YP_002344712.1 218562933 905614 1251467..1251787 1 NC_002163.1 Original (2000) note: Cj1322, unknown, len: 106 aa; no Hp match; Updated (2006) note: Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Literature search identified paper linking Cj1321-Cj1326 as being a glycosylation islet (PMID:16230626). Functional classification - Unknown; PMID:16230626, PMID:12586395, PMID:16573682,PMID:12781527; hypothetical protein 1251787 905614 Cj1322 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344712.1 1251467 D 192222 CDS YP_002344713.1 218562934 905615 1251775..1252161 1 NC_002163.1 Original (2000) note: Cj1323, unknown, len: 128 aa; no Hp match; Updated (2006) note: Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Literature search identified paper linking Cj1321-Cj1326 as being a glycosylation islet (PMID:16230626). Functional classification - Unknown; PMID:16230626, PMID:16573682, PMID:12781527; hypothetical protein 1252161 905615 Cj1323 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344713.1 1251775 D 192222 CDS YP_002344714.1 218562935 905616 1252278..1253399 1 NC_002163.1 Original (2000) note: Cj1324, unknown, len: 373 aa; some similarity to TR:P72140 (EMBL:U50396) Pseudomonas aeruginosa WBPG (lipopolysaccharide gene cluster) (376 aa), fasta scores; opt: 166 z-score: 199.7 E(): 0.0008,20.1% identity in 378 aa overlap. No Hp match. Also similar to Cj1316c; Updated (2006) note: Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Literature search identified paper linking Cj1321-Cj1326 as being a glycosylation islet (PMID:16230626). Also shows some similarity to Cj1316 pseudaminic acid biosynthesis PseA protein. Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:16230626, PMID:16573682, PMID:12781527; hypothetical protein 1253399 905616 Cj1324 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344714.1 1252278 D 192222 CDS YP_002344715.1 218562936 905617 join(1253417..1253671,1253673..1254092) 1 NC_002163.1 Original (2000) note: Cj1326, unknown, len: 140 aa; no Hp match. Contains polyporphic sequence G(9-10) at N-terminus; G(9) allows translation from the upstream CDS Cj1325, G(10) (consensus) would only allow this CDS to start at aa 22. Similar to Cj0171 (51.9% identity in 135 aa overlap), which also contains a polymorphic sequence allowing possible translation from Cj0170; Original (2000) note: Cj1325, unknown, len: 89 aa; no Hp match. Contains polyporphic sequence G(9-10) at C-terminus; G(10) (consensus) gives this translation stop,G(9) allows translation into the downstream CDS Cj1326. Similar to Cj0170 (73.8% identity in 61 aa overlap), which also contains a polymorphic sequence allowing possible translation into Cj0171; Updated (2006) note: Pfam domains PF08241 and PPF08242 both Methyltransferase domains were identified within CDS. Product function modified to more specific family member. No specific characterisation has been carried out yet. kept within product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Literature search identified paper linking Cj1321-Cj1326 as being a glycosylation islet (PMID:16230626). Coding sequences have been merged to reflect the complete amino acid sequence for this gene regardless of phase. Previous annotation gave Cj1325 and Cj1326 as seperate CDS. Merging of these CDSs has lead to loss of the downstream CDS. Functional classification - Misc; PMID:16230626, PMID:14985343; methyltransferase 1254092 905617 Cj1325 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methyltransferase YP_002344715.1 1253417 D 192222 CDS YP_002344716.1 218562937 905619 1254132..1255136 1 NC_002163.1 Original (2000) note: Cj1327, neuB2,N-acetylneuraminic acid synthetase, len: 334 aa; similar to e.g. TR:Q46675 (EMBL:U05248) E.coli polysialic acid gene cluster region 2 neuB (346 aa), fasta scores; opt: 1112 z-score: 1285.6 E(): 0, 51.5% identity in 336 aa overlap, and TR:Q57265 (EMBL:U40740) Neisseria meningitidis N-acetylneuraminic acid synthetase (EC 4.1.3.-) (349 aa), fasta scores; opt: 624 z-score: 724.6 E(): 4.6e-33, 34.5% identity in 333 aa overlap; Updated (2006) note: Pfam domains PF03102 NeuB family was identified within CDS. Prosite domains PS00141 ASP_PROTEASE, Peptidase aspartic, active site and PS00867 CPSASE_2, Carbamoyl-phosphate synthase L chain,ATP-binding were both identified within CDS. Further support given to product function. Characterised within Campylobacter jejuni (PMID:10712693). not added to product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:10712693, PMID:16573682, PMID:12781527; N-acetylneuraminic acid synthetase 1255136 neuB2 905619 neuB2 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 N-acetylneuraminic acid synthetase YP_002344716.1 1254132 D 192222 CDS YP_002344717.1 218562938 905620 1255129..1256283 1 NC_002163.1 Original (2000) note: Cj1328, neuC2, probable N-acetylglucosamine-6-phosphate 2-epimerase/N-acetylglucosamine-6-phosphatase, len: 371 aa; similar to e.g. TR:Q47400 (EMBL:M84026) E. coli neuC (391 aa), fasta scores; opt: 779 z-score: 889.7 E(): 0,36.1% identity in 388 aa overlap, and TR:Q57141 (EMBL:X78068) Neisseria meningitidis N-acetylglucosamine-6-phosphate 2-epimerase (EC 5.1.3.-) / N-acetylglucosamine-6-phosphatase (EC 3.1.3.-) (377 aa),fatsta scores; opt: 561 z-score: 642.7 E(): 1.7e-28, 33.5% identity in 391 aa overlap. No Hp match. Also similar to Cj1142 (34.6% identity in 384 aa overlap); Updated (2006) note: Some characterisation work within Campylobacter coli (PMID:8825781, PMID:12406231). Product function updated and kept within product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Surface structures; PMID:10712693, PMID:16573682, PMID:12781527,PMID:16481326, PMID:12406231, PMID:8825781; UDP-N-acetylglucosamine 2-epimerase 1256283 neuC2 905620 neuC2 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-N-acetylglucosamine 2-epimerase YP_002344717.1 1255129 D 192222 CDS YP_002344718.1 218562939 905621 1256292..1257317 1 NC_002163.1 Original (2000) note: Cj1329, probable sugar-phosphate nucleotide transferase, len: 341 aa; similar in C-term (120 aa - end) to many predicted transferases, and to MPG1_YEAST mannose-1-phosphate guanyltransferase (361 aa), fasta scores; opt: 304 z-score: 343.2 E(): 8.1e-12, 28.9% identity in 225 aa overlap. N-term has some similarity to CBS domains in nucleotide dehydrogenases e.g. IMDH_BACSU inosine-5'-monophosphate dehydrogenase (513 aa), blastp scores; E=0.00034, 30% identity in 116 overlap. N-term contains 2x Pfam match to entry PF00571 CBS, CBS domain,C-term contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. No Hp match. Also similar in C-terminus to Cj1423c (35.6% identity in 216 aa overlap); Updated (2006) note: Some characterisation work carried out in Campylobacter coli (PMID:12406231). Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:16573682, PMID:12781527, PMID:12406231; sugar-phosphate nucleotide transferase 1257317 905621 Cj1329 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sugar-phosphate nucleotide transferase YP_002344718.1 1256292 D 192222 CDS YP_002344719.1 218562940 905622 1257314..1258219 1 NC_002163.1 Original (2000) note: Cj1330, unknown, len: 301 aa; some similarity to predicted oxidoreductases e.g. TR:O26961 (EMBL:AE000863) Methanobacterium thermoautotrophicum MTH875 (predicted 3-chlorobenzoate-3,4-dioxygenase dyhydrogenase related protein) (318 aa), fasta scores; opt: 199 z-score: 244.0 E(): 2.7e-06, 24.7% identity in 267 aa overlap, and TR:Q53739 (EMBL:X92429) Streptomyces alboniger predicted oxido-reductase (338 aa), fasta scores; opt: 135 z-score: 167.8 E(): 0.048, 27.0% identity in 196 aa overlap. No Hp match; Updated (2006) note: Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Conserved hypothetical proteins; PMID:16573682, PMID:12781527; hypothetical protein 1258219 905622 Cj1330 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344719.1 1257314 D 192222 CDS YP_002344720.1 218562941 905623 1258212..1258919 1 NC_002163.1 Original (2000) note: Cj1331, ptmB, neuA3, probable acylneuraminate cytidylyltransferase (CMP-N-acetylneuraminic acid synthetase), len: 235 aa; 83.8% identical to PTMB_CAMCO posttranslational flagellin modification protein B (235 aa), and simlar to e.g. NEUA_NEIME acylneuraminate cytidylyltransferase (EC 2.7.7.43) (228 aa), fasta scores; opt: 357 z-score: 438.8 E(): 3.8e-17, 30.1% identity in 226 aa overlap. No Hp ortholog. Also similar to e.g. Cj1311 neuA2 (32.9% identity in 234 aa overlap) and Cj1143 neuA (34.7% identity in 219 aa overlap); Updated (2006) note: Pfam domain PF02348 Cytidylyltransferase identified within CDS. Further support given to product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Surface structures; PMID:16573682, PMID:12781527, PMID:8825781; acylneuraminate cytidylyltransferase 1258919 ptmB 905623 ptmB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acylneuraminate cytidylyltransferase YP_002344720.1 1258212 D 192222 CDS YP_002344721.1 218562942 905624 1258919..1259689 1 NC_002163.1 Original (2000) note: Cj1332, ptmA, probable oxidoreductase, len: 256 aa; 79.3% identical to PTMA_CAMCO posttranslational flagellin modification protein A (256 aa), and similar to e.g. DHG2_BACME glucose 1-dehydrogenase II (261 aa), fasta scores; opt: 236 z-score: 281.8 E(): 2.1e-08, 24.1% identity in 261 aa overlap. No Hp ortholog. Contains fam match to entry PF00106 adh_short, Alcohol/other dehydrogenases, short chain type, and Pfam match to entry PF00678 adh_short_C2,Short chain dehydrogenase/reductase C-terminus; Updated (2006) note: kept within product function. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Surface structures; PMID:16573682, PMID:12781527, PMID:8825781; flagellin modification protein A 1259689 ptmA 905624 ptmA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellin modification protein A YP_002344721.1 1258919 D 192222 CDS YP_002344722.1 218562943 905625 1259677..1261638 1 NC_002163.1 Original (2000) note: Cj1333, unknown, len: 653 aa; no Hp ortholog, but 34.6% identity to HP0114. A member of the 1318 family of proteins. Similar to Cj1318 (72.5% identity in 658 aa overlap), Cj1337 (48.6% identity in 636 aa overlap), Cj1334 (41.8% identity in 644 aa overlap),Cj1340c (30.4% identity in 615 aa overlap), Cj1341c (31.2% identity in 616 aa overlap) and Cj1335/Cj1336 (94.2% identity in 52 aa overlap/71.7% identity in 597 aa overlap); Updated (2006) note: Pfam domain PF01973 Protein of unknown function DUF115 identified within CDS. Characterised work has been carried out within Campylobacter jejuni (PMID:16573682) and noted to play a role in attachment of pseudaminic acid. Previously designated at Maf2 (motility accessory protein). Recently shown to play no part in CMP-Pse5NAc7NAc or CMP-Pse5NAc7Am pathyways. Logan (Susan.Logan@nrc-cnrc.gc.ca) personal communication. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Misc; PMID:11832511, PMID:11895937, PMID:16573682,PMID:12781527, PMID:11895937, PMID:16573682; PseD protein 1261638 pseD 905625 pseD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 PseD protein YP_002344722.1 1259677 D 192222 CDS YP_002344723.1 218562944 905626 1261635..1263494 1 NC_002163.1 Original (2000) note: Cj1334, unknown, len: 619 aa; no Hp ortholog, but 34.8% identity to HP0114. A member of the 1318 family of proteins. Similar to Cj1333 (41.9% identity in 645 aa overlap), Cj1318 (41.0% identity in 647 aa overlap), Cj1336 (41.9% identity in 590 aa overlap),Cj1337 (43.8% identity in 628 aa overlap), Cj1341c (34.3% identity in 621 aa overlap), and Cj1340c (34.0% identity in 618 aa overlap); Updated (2006) note: Pfam domain PF01973 Protein of unknown function DUF115 identified within CDS. Some characterisation work has been carried out within Campylobacter jejuni. Product funciton updated to more specific family member. Recently shown to play no part in CMP-Pse5NAc7NAc or CMP-Pse5NAc7Am pathyways. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Misc; PMID:11832511, PMID:16573682, PMID:12781527,PMID:16573682; motility accessory factor 1263494 maf3 905626 maf3 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 motility accessory factor YP_002344723.1 1261635 D 192222 CDS YP_002344724.1 218562945 905627 join(1263507..1263677,1263676..1265454) 1 NC_002163.1 Original (2000) note: Cj1335, unknown, len: 60 aa; no Hp match. A member of the 1318 family of proteins. Identical to the N-terminus of Cj1318 (100.0% identity in 59 aa overlap) and similar to Cj1333 (94.2% identity in 52 aa overlap). Contains a G(9-10) polymorphic region at aa 57. G(9) (consensus) gives this ORF, G(10) would extend the ORF by 18 aa. G(8) or G(11) (not seen in shotgun) would allow translation into the downstream ORF Cj1336,giving a protein similar to other members of the 1318 family; Original (2000) note: Cj1336, unknown, len: 593 aa; no Hp ortholog, but 34.0% identity to HP0114. A member of the 1318 family of proteins. Identical to Cj1318 (except the C-term, 100.0% identity in 592 aa overlap), ands similar to Cj1333 (71.7% identity in 597 aa overlap),Cj1334 (42.3% identity in 591 aa overlap), Cj1337 (48.6% identity in 586 aa overlap), Cj1341c (30.8% identity in 578 aa overlap) and Cj1340c (32.0% identity in 579 aa overlap). Contains a G(9-10) polymorphic region at aa 2. G(9) (consensus) gives this ORF, G(10) would allow translation to start at aa 21. G(8) or G(11) (not seen in shotgun) would allow translation from the upstream ORF Cj1335, giving a protein similar to other members of the 1318 family; Updated (2006) note: Pfam domain PF01973 Protein of unknown function DUF115 identified within CDS. Some characterisation work has been carried out within Campylobacter jejuni. Product funciton updated to more specific family member. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Coding sequences have been merged to reflect the complete amino acid sequence for this gene regardless of phase. Previous annotation gave Cj1335 and Cj1336 as seperate CDS. Merging of these CDSs has lead to loss of the downstream CDS. Functional classification - Misc; PMID:11832511, PMID:16573682, PMID:12781527; motility accessory factor 1265454 maf4 905627 maf4 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 motility accessory factor YP_002344724.1 1263507 D 192222 CDS YP_002344725.1 218562946 905629 1265451..1267337 1 NC_002163.1 Original (2000) note: Cj1337, unknown, len: 628 aa; 35.0% identity to HP0114. A member of the 1318 family of proteins. Simlar to Cj1333 (48.6% identity in 636 aa overlap), Cj1318 (48.1% identity in 643 aa overlap),Cj1336 (48.6% identity in 586 aa overlap), Cj1334 (43.6% identity in 628 aa overlap), Cj1340c (32.2% identity in 624 aa overlap), Cj1341c (31.9% identity in 627 aa overlap); Updated (2006) note: Pfam domain PF01973 Protein of unknown function DUF115 identified within CDS. Some characterisation work carried out within Campylobacter jejuni. Product function modified. Recent research has shown that PseE does not play a role in the pseudaminic acid pathway, however, may be involved in glycan transfer to flagellin (PMID:16684771). Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Misc; PMID:16684771, PMID:16573682, PMID:12781527,PMID:11461915; PseE protein 1267337 pseE 905629 pseE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 PseE protein YP_002344725.1 1265451 D 192222 CDS YP_002344726.1 218562947 905630 complement(1267368..1269086) 1 NC_002163.1 FlaB; structural flagella protein; in Helicobacter the flagella are composed of flagellin A and flagellin B; the amounts of each seem to be controlled by environmental conditions; flagellin 1269086 flaB 905630 flaB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellin YP_002344726.1 1267368 R 192222 CDS YP_002344727.1 218562948 905631 complement(1269232..1270950) 1 NC_002163.1 FlaA; structural flagella protein; in Helicobacter the flagella are composed of flagellin A and flagellin B; the amounts of each seem to be controlled by environmental conditions; flagellin 1270950 flaA 905631 flaA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellin YP_002344727.1 1269232 R 192222 CDS YP_002344728.1 218562949 905632 complement(1271047..1272864) 1 NC_002163.1 Original (2000) note: Cj1340c, unknown, len: 605 aa; no Hp ortholog, but 28.5% identity to HP0114. A member of the 1318 family of proteins. Similar to Cj1341c (83.4% identity in 598 aa overlap), Cj1337 (32.5% identity in 625 aa overlap), Cj1333 (30.4% identity in 615 aa overlap),Cj1336 (32.0% identity in 579 aa overlap), Cj1318 (31.4% identity in 641 aa overlap), and Cj1334 (34.1% identity in 618 aa overlap); Updated (2006) note: Pfam domain PF01973 Protein of unknown function DUF115 identified within CDS. Conserved added to product function. Literature search identified paper giving further clues to product function (PMID:11895937). Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Conserved hypothetical proteins; PMID:11895937, PMID:16573682, PMID:12781527; hypothetical protein 1272864 905632 Cj1340c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344728.1 1271047 R 192222 CDS YP_002344729.1 218562950 905633 complement(1272861..1274684) 1 NC_002163.1 Original (2000) note: Cj1341c, unknown, len: 607 aa; no Hp ortholog, but 28.4% identity to HP0114. A member of the 1318 family of proteins. Similar to Cj1340c (83.4% identity in 598 aa overlap), Cj1334 (34.6% identity in 622 aa overlap), Cj1336 (30.8% identity in 578 aa overlap),Cj1333 (31.2% identity in 616 aa overlap), Cj1318 (30.2% identity in 640 aa overlap), and Cj1337 (32.0% identity in 628 aa overlap); Updated (2006) note: Pfam domain PF01973 Protein of unknown function DUF115 identified within CDS. Some characterisation work carried out within Campylobacter jejuni. Product modified to more specific family member. Recently shown to play no part in CMP-Pse5NAc7NAc or CMP-Pse5NAc7Am pathyways. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Misc; PMID:11832511, PMID:16573682, PMID:12781527,PMID:16573682; motility accessory factor 1274684 maf6 905633 maf6 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 motility accessory factor YP_002344729.1 1272861 R 192222 CDS YP_002344730.1 218562951 905634 complement(1274694..1275935) 1 NC_002163.1 Original (2000) note: Cj1342c, unknown, len: 413 aa; no Hp match. A member of the 617 family of C.j. proteins containing homopolymeric tracts; similar to Cj1310c (37.3% identity in 424 aa overlap), Cj1305c (38.5% identity in 423 aa overlap), Cj0617/Cj0618 (49.7% identity in 191 aa overlap/43.4% identity in 221 aa overlap),Cj1306c (38.3% identity in 426 aa overlap). Contains C(9-10) polymorphic region at aa 188. C(9) consensus gives this ORF, C(10) gives truncation after a further 19 aa; Updated (2006) note: Some characterisation work carried out within Campylobacter jejuni. Product modified to more specific family member.Recently shown to play no part in CMP-Pse5NAc7NAc or CMP-Pse5NAc7Am pathyways. Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Functional classification - Misc; PMID:11832511, PMID:16573682, PMID:12781527,PMID:16573682; motility accessory factor 1275935 maf7 905634 maf7 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 motility accessory factor YP_002344730.1 1274694 R 192222 CDS YP_002344731.1 218562952 905635 complement(1275935..1276450) 1 NC_002163.1 Original (2000) note: Cj1343c, probable periplasmic protein, len: 171 aa; no Hp match. Some similarity to N-terminus of secretion proteins e.g. GSPG_ECOLI general secretion pathway protein (145 aa), fasta scores; opt: 153 z-score: 192.8 E(): 0.0019, 35.6% identity in 59 aa overlap. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF07963 Prokaryotic N-terminal methylation motif identified within CDS. Further support given to product function. Literature search identified paper giving further clues to product function. Functional classification - Miscellaneous periplasmic proteins; PMID:12949093; periplasmic protein 1276450 905635 Cj1343c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344731.1 1275935 R 192222 CDS YP_002344732.1 218562953 905636 complement(1276451..1277458) 1 NC_002163.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 1277458 905636 Cj1344c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA-binding/iron metalloprotein/AP endonuclease YP_002344732.1 1276451 R 192222 CDS YP_002344733.1 218562954 905637 complement(1277455..1278849) 1 NC_002163.1 Original (2000) note: Cj1345c, probable periplasmic protein, len: 464 aa; 41.2% identity to HP1075. Contains probable N-terminal signal sequence; Updated (2006) note: Paper identified linking protein to glycoprotein. Functional classification -Miscellaneous periplasmic proteins; PMID:12186869; periplasmic protein 1278849 905637 Cj1345c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344733.1 1277455 R 192222 CDS YP_002344734.1 218562955 905638 complement(1278851..1279921) 1 NC_002163.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1279921 dxr 905638 dxr Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_002344734.1 1278851 R 192222 CDS YP_002344735.1 218562956 905639 complement(1279918..1280643) 1 NC_002163.1 Original (2000) note: Cj1347c, cdsA, probable phosphatidate cytidylyltransferase, len: 241 aa; similar to e.g. CDSA_ECOLI phosphatidate cytidylyltransferase (EC 2.7.7.41) (249 aa), fasta scores; opt: 381 z-score: 465.5 E(): 1.2e-18, 40.7% identity in 182 aa overlap. 39.3% identity to HP0215. Contains PS01315 Phosphatidate cytidylyltransferase signature, and Pfam match to entry PF01148 Cytidylyltrans, Phosphatidate cytidylyltransferase; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. not added to product function. Seven probable transmembrane helices predicted by TMHMM2.0. Functional classification - Fatty acid biosynthesis; PMID:9083091, PMID:2995359; phosphatidate cytidylyltransferase 1280643 cdsA 905639 cdsA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphatidate cytidylyltransferase YP_002344735.1 1279918 R 192222 CDS YP_002344736.1 218562957 905640 complement(1280652..1280990) 1 NC_002163.1 Original (2000) note: Cj1348c, probable coiled-coil protein, len: 112 aa; Lys-, Glu-rich, highly hydrophilic,contains probable coiled-coil from approx aa 50-80. No Hp match. Functional classification - Unknown; coiled-coil protein 1280990 905640 Cj1348c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 coiled-coil protein YP_002344736.1 1280652 R 192222 CDS YP_002344737.1 218562958 905641 complement(1280992..1282299) 1 NC_002163.1 Original (2000) note: Cj1349c, possible fibronectin/fibrinogen-binding protein, len: aa; similar to TR:Q54858 (EMBL:L28919) Streptococcus pyogenes fibronectin/fibrinogen-binding protein FBP54 (474 aa),fasta scores; opt: 213 z-score: 230.0 E(): 1.7e-05, 23.2% identity in 466 aa overlap. 30.6% identity to HP1392; Updated (2006) note: Pfam domain PF05670 Domain of unknown function (DUF814) identified within CDS. No specific characterisation with acceptable identity score carried out yet, so kept within product function. Functional classification - Pathogenicity; fibronectin/fibrinogen-binding protein 1282299 905641 Cj1349c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 fibronectin/fibrinogen-binding protein YP_002344737.1 1280992 R 192222 CDS YP_002344738.1 218562959 905642 1282361..1282936 1 NC_002163.1 Original (2000) note: Cj1350, mobA, probable molybdopterin-guanine dinucleotide biosynthesis protein,len: 191 aa; similar to e.g. MOBA_ECOLI molybdopterin-guanine dinucleotide biosynthesis protein A (194 aa), fasta scores; opt: 194 z-score: 249.0 E(): 1.5e-06, 22.9% identity in 192 aa overlap. 26.6% identity to HP0769; Updated (2006) note: Some characterisation in Escherichia coli, however, identity score was unacceptable. Thus, kept within product function. Functional classification - Biosynthesis of cofactors,prosthetic groups and carriers - Molybdopterin; PMID:10978347; molybdopterin-guanine dinucleotide biosynthesis protein 1282936 mobA 905642 mobA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molybdopterin-guanine dinucleotide biosynthesis protein YP_002344738.1 1282361 D 192222 CDS YP_002344739.1 218562960 905643 1282933..1283922 1 NC_002163.1 Original (2000) note: Cj1351, pldA, probable phospholipase A, len: 329 aa; highly similar to TR:O32349 (EMBL:Y11031) Campylobacter coli phospholipase A (297 aa),fasta scores; opt: 1544 z-score: 1835.1 E(): 0, 75.2% identity in 298 aa overlap, and similar to e.g. PA1_ECOLI phospholipase A1 precursor (EC 3.1.1.32) (289 aa), fasta scores; opt: 467 z-score: 560.5 E(): 6.4e-24, 34.7% identity in 262 aa overlap. 25.5% identity to HP0499. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF02253 Phospholipase A1 identified within CDS. Further support given to product function. Characterised within Campylobacter coli, so not added to product function (PMID:9119448). Functional classification -Pathogenicity; PMID:9119448, PMID:8300539; phospholipase A 1283922 pldA 905643 pldA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phospholipase A YP_002344739.1 1282933 D 192222 CDS YP_002344740.1 218562961 905644 1284008..1284976 1 NC_002163.1 Original (2000) note: Cj1352, ceuB, probable enterochelin uptake permease, len: 322 aa; highly similar to TR:Q46003 (EMBL:X88849) Campylobacter coli ceuB (322 aa), fasta scores; opt: 1839 z-score: 2038.7 E(): 0, 89.1% identity in 322 aa overlap, and similar to e.g. FATD_VIBAN ferric anguibactin transport system permease FATD (314 aa), fasta scores; opt: 921 z-score: 1026.8 E(): 0,43.3% identity in 305 aa overlap. Also similar to Cj1615 (31.0% identity in 326 aa overlap), and Cj1353 (27.2% identity in 316 aa overlap). Contains Pfam match to entry PF01032 FecCD_family, FecCD transport family; Updated (2006) note: Nine probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised within Campylobacter coli,so not added to product function. Functional classification - Transport/binding proteins - Cations; PMID:8574410; enterochelin uptake permease 1284976 ceuB 905644 ceuB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 enterochelin uptake permease YP_002344740.1 1284008 D 192222 CDS YP_002344741.1 218562962 905645 1284969..1285907 1 NC_002163.1 Original (2000) note: Cj1353, ceuC, probable enterochelin uptake permease, len: 312 aa; highly similar to TR:Q46004 (EMBL:X88849) Campylobacter coli ceuC (312 aa), fasta scores; opt: 1784 z-score: 2112.8 E(): 0, 88.8% identity in 312 aa overlap, and similar to e.g. FATC_VIBAN ferric anguibactin transport system permease FATC (317 aa), fasta scores; opt: 593 z-score: 708.6 E(): 3.6e-32, 31.7% identity in 306 aa overlap. No Hp ortholog. Also similar to e.g. Cj1352 (27.2% identity in 316 aa overlap), and Cj1615 (27.5% identity in 298 aa overlap). Contains Pfam match to entry PF01032 FecCD_family, FecCD transport family; Updated (2006) note: Nine probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised within Campylobacter coli,so not added to product function. Functional classification - Transport/binding proteins - Cations; PMID:8574410; enterochelin uptake permease 1285907 ceuC 905645 ceuC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 enterochelin uptake permease YP_002344741.1 1284969 D 192222 CDS YP_002344742.1 218562963 905646 1285904..1286659 1 NC_002163.1 Original (2000) note: Cj1354, ceuD, probable enterochelin uptake ATP-binding protein, len: 251 aa; highly similar to TR:Q46005 (EMBL:X88849) Campylobacter coli ceuD (251 aa), fasta scores; opt: 1258 z-score: 1347.9 E(): 0, 82.5% identity in 246 aa overlap, and similar to e.g. FHUC_BACSU ferrichrome transport ATP-binding protein (269 aa), fasta scores; opt: 613 z-score: 663.4 E(): 1.2e-29, 38.0% identity in 245 aa overlap. No Hp ortholog. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran, ABC transporters; Updated (2006) note: Characterised within Campylobacter coli, so not added to product function. Functional classification - Transport/binding proteins - Cations; PMID:8574410; enterochelin uptake ATP-binding protein 1286659 ceuD 905646 ceuD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 enterochelin uptake ATP-binding protein YP_002344742.1 1285904 D 192222 CDS YP_002344743.1 218562964 905647 1286672..1287664 1 NC_002163.1 Original (2000) note: Cj1355, ceuE, probable enterochelin uptake periplasmic binding protein, len: 330 aa; highly similar to TR:Q46006 (EMBL:X88849) Campylobacter coli ceuE (328 aa), fasta scores; opt: 1903 z-score: 2111.3 E(): 0, 90.6% identity in 330 aa overlap,and similar to e.g. FATB_VIBAN ferric anguibactin-binding protein precursor (322 aa), fasta scores; opt: 540 z-score: 605.4 E(): 2e-26, 30.1% identity in 279 aa overlap. No Hp match. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) note: Characterised within Campylobacter coli, so not added to product function. Pfam domain PF01497 Periplasmic binding protein identified within CDS. Further support given to product function. Functional classification - Transport/binding proteins - Cations; PMID:8574410; enterochelin uptake periplasmic binding protein 1287664 ceuE 905647 ceuE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 enterochelin uptake periplasmic binding protein YP_002344743.1 1286672 D 192222 CDS YP_002344744.1 218562965 905649 complement(1287890..1288444) 1 NC_002163.1 Original (2000) note: Cj1356c, probable integral membrane protein, len: 184 aa; highly similar to TR:Q46007 (EMBL:X88849) Campylobacter coli ORF (210 aa), fasta scores; opt: 545 z-score: 652.8 E(): 4.6e-29, 67.1% identity in 210 aa overlap. 31.8% identity to HP0234; Updated (2006) note: Three probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 1288444 905649 Cj1356c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344744.1 1287890 R 192222 CDS YP_002344745.1 218562966 905650 complement(1288580..1290412) 1 NC_002163.1 Original (2000) note: Cj1357c, probable periplasmic cytochrome C, len: 610 aa; similar to e.g. NRFA_ECOLI cytochrome C552 precursor (478 aa), fasta scores; opt: 298 z-score: 333.9 E(): 2.7e-11, 31.0% identity in 455 aa overlap. No Hp match. Contains probable N-terminal signal sequence and 5x PS00190 Cytochrome c family heme-binding site signature; Updated (2006) note: Pfam domain PF02335 Cytochrome c552 was identified within CDS. Further support given to product function. Characterisation work carried out within Wolinella succinogenes (PMID:10672190, PMID:10984487). Identity score was marginal. kept within product function. Functional classification - Energy metabolism -Electron transport; PMID:10672190, PMID:10984487, PMID:12095623,PMID:12618466; periplasmic cytochrome C 1290412 nrfA 905650 nrfA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic cytochrome C YP_002344745.1 1288580 R 192222 CDS YP_002344746.1 218562967 905651 complement(1290427..1290942) 1 NC_002163.1 Original (2000) note: Cj1358c, probable periplasmic cytochrome C, len: 171 aa; similar to e.g. NAPC_ECOLI cytochrome C-type protein NAPC (200 aa), fasta scores opt: 201 z-score: 242.9 E(): 3.1e-06, 34.5% identity in 165 aa overlap. No Hp match. Contains probable N-terminal signal sequence and 3x PS00190 Cytochrome c family heme-binding site signature; Updated (2006) note: Pfam domain PF03264 NapC/NirT cytochrome c family, N-terminal was identified within CDS. Further support given to product function. Characterisation work carried out within Wolinella succinogenes (PMID:10672190). Identity score was marginal. was kept within product function. Functional classification - Energy metabolism - Electron transport; PMID:10672190, PMID:12095623, PMID:12618466; periplasmic cytochrome C 1290942 nrfH 905651 nrfH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic cytochrome C YP_002344746.1 1290427 R 192222 CDS YP_002344747.1 218562968 905652 1291131..1293215 1 NC_002163.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 1293215 ppk 905652 ppk Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 polyphosphate kinase YP_002344747.1 1291131 D 192222 CDS YP_002344748.1 218562969 905653 complement(1293527..>1293571) 1 NC_002163.1 Original (2000) note: Cj1360c, probable proteolysis tag for 10Sa_RNA ((A)ANNVKFAPAYAKAA), len: 14 aa; similar to TR:P96347 (EMBL:U68082) H. pylori coded portion of proteolysis tag (fragment) (14 aa), fasta scores; opt: 66 z-score: 192.9 E(): 0.0019, 76.9% identity in 13 aa overlap. Corresponds to c(838688..838726) in Hp seq. Functional classification - Degradation of macromolecules - Proteins, peptides and glycopeptides; proteolysis tag for 10Sa_RNA >1293571 905653 Cj1360c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 proteolysis tag for 10Sa_RNA YP_002344748.1 1293527 R 192222 CDS YP_002344749.1 218562970 905654 complement(1293659..1294111) 1 NC_002163.1 Original (2000) note: Cj1361c, unknown, len: 150 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 1294111 905654 Cj1361c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344749.1 1293659 R 192222 CDS YP_002344750.1 218562971 905655 1294160..1295167 1 NC_002163.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1295167 ruvB 905655 ruvB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Holliday junction DNA helicase RuvB YP_002344750.1 1294160 D 192222 CDS YP_002344751.1 218562972 905656 1295171..1296214 1 NC_002163.1 Original (2000) note: Cj1363, amaA, acid membrane antigen A, len: 347 aa; similar to many hypothetical membrane proteins e.g. TR:O66948 (EMBL:AE000705) Aquifex aeolicus AQ_740 (353 aa), fasta scores; opt: 268 z-score: 311.7 E(): 4.6e-10, 24.1% identity in 352 aa overlap. 32.2% identity to HP0567. Identical in part to TR:O69293 (EMBL:Y16882) C. jejuni predicted outer membrane protein from rearranged lambda clone (364 aa). (Phillippa Connerton(p.connerton@ic.ac.uk) pers. comm.); Updated (2006) note: Seven probable transmembrane helices predicted by TMHMM2.0. Pfam domain PF01594 Domain of unknown function DUF20 also identified within CDS. Functional classification - Membranes, lipoproteins and porins; acid membrane antigen A 1296214 amaA 905656 amaA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acid membrane antigen A YP_002344751.1 1295171 D 192222 CDS YP_002344752.1 218562973 905657 complement(1296244..1297635) 1 NC_002163.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1297635 fumC 905657 fumC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 fumarate hydratase YP_002344752.1 1296244 R 192222 CDS YP_002344753.1 218562974 905658 complement(1297691..1300816) 1 NC_002163.1 Original (2000) note: Cj1365c, probable secreted serine protease, len: 1041 aa; similar to e.g. TR:Q54484 (EMBL:D78380) Serratia marcescens serine protease homologue SSP-H2 (1034 aa), fasta scores; opt: 245 z-score: 257.1 E(): 5.1e-07, 23.5% identity in 591 aa overlap, and PRTS_SERMA extracellular serine protease precursor (EC 3.4.21.-) (1045 aa), fasta scores; opt: 205 z-score: 214.6 E(): 0.00012, 23.7% identity in 615 aa overlap. No Hp match. Contains PS00137 Serine proteases,subtilase family, histidine active site, PS00138 Serine proteases, subtilase family, serine active site, Pfam match to entry PF00082 subtilase, Subtilase family of serine proteases, and probable N-terminal signal sequence; Updated (2006) note: Specific characterisation with acceptable identity scores not carried out yet, so kept within product function. Functional classification - Degradation of macromolecules - Proteins,peptides and glycopeptides; secreted serine protease 1300816 905658 Cj1365c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 secreted serine protease YP_002344753.1 1297691 R 192222 CDS YP_002344754.1 218562975 905659 complement(1300819..1302615) 1 NC_002163.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 1302615 glmS 905659 glmS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glucosamine--fructose-6-phosphate aminotransferase YP_002344754.1 1300819 R 192222 CDS YP_002344755.1 218562976 905660 complement(1302620..1304968) 1 NC_002163.1 Original (2000) note: Cj1367c, possible nucleotidyltransferase, len: 782 aa; weak similarity to TR:Q53245 (EMBL:U47030) Rhizobium tropici uridylyltransferase/uridylyl-removing enzyme (971 aa),fasta scores; opt: 202 z-score: 226.1 E(): 2.7e-05, 19.7% identity in 857 aa overlap, and GLND_HAEIN [protein-PII] uridylyltransferase (863 aa), fasta scores; opt: 119 z-score: 133.2 E(): 4, 19.5% identity in 822 aa overlap,(blastp score; E=4.3e-07). No Hp match. Contains C(1-2) polymorphic region at aa 148; C(2) (consensus) gives this ORF, C(1) gives truncation after +8 aa; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet, so kept within product funciton. Functional classification - Misc; nucleotidyltransferase 1304968 905660 Cj1367c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 nucleotidyltransferase YP_002344755.1 1302620 R 192222 CDS YP_002344756.1 218562977 905661 1305112..1306176 1 NC_002163.1 Original (2000) note: Cj1368, unknown, len: 354 aa; similar to hypothetical proteins e.g. TR:O66888 (EMBL:AE000700) Aquifex aeolicus AQ_648 (371 aa), fasta scores; opt: 956 z-score: 1117.5 E(): 0, 44.1% identity in 349 aa overlap. 57.4% identity to HP0654. Also similar to Cj0462 (35.5% identity in 349 aa overlap); Updated (2006) note: Pfam domain PF04055 Radical SAM superfamily identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation carried out yet, so kept within product function. Functional classification -Misc; hypothetical protein 1306176 905661 Cj1368 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344756.1 1305112 D 192222 CDS YP_002344757.1 218562978 905662 1306186..1307505 1 NC_002163.1 Original (2000) note: Cj1369, probable transmembrane transport protein, len: 439 aa; similar to many hypothetical membrane proteins e.g. YJCD_ECOLI (449 aa), fasta scores; opt: 897 z-score: 1039.1 E(): 0, 34.7% identity in 429 aa overlap. 50.7% identity to HP1175. Contains Pfam match to entry PF00860 xan_ur_permease,Xanthine/uracil permeases family; Updated (2006) note: Pfam domain PF00860 Permease family protein identified within CDS. Also, thirteen probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member based on motif search. No specific characterisation has been been carried out yet, so kept within product function. Functional classification - Transport/binding proteins -Other; permease 1307505 905662 Cj1369 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 permease YP_002344757.1 1306186 D 192222 CDS YP_002344758.1 218562979 905663 1307519..1307962 1 NC_002163.1 Original (2000) note: Cj1370, possible nucleotide phosphoribosyltransferase, len: 147 aa; similar to e.g. TR:O50284 (EMBL:AF035967) hypoxanthine ribosyl transferase (176 aa), fasta scores; opt: 158 z-score: 205.5 E(): 0.00038, 26.2% identity in 145 aa overlap, and XGPT_ECOLI xanthine-guanine phosphoribosyltransferase (152 aa), fasta scores; opt: 128 z-score: 170.3 E(): 0.035, 24.6% identity in 142 aa overlap. 39.5% identity to HP0735. Contains PS00103 Purine/pyrimidine phosphoribosyl transferases signature; Updated (2006) note: Pfam domain PF00156 Phosphoribosyl transferase domain identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet, so kept within product function. Functional classification - Salvage of nucleosides and nucleotides; nucleotide phosphoribosyltransferase 1307962 905663 Cj1370 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 nucleotide phosphoribosyltransferase YP_002344758.1 1307519 D 192222 CDS YP_002344759.1 218562980 905664 1308007..1308705 1 NC_002163.1 Original (2000) note: Cj1371, probable periplasmic protein (vacJ homolog), len: 232 aa; similar to e.g. VACJ_SHIFL VACJ lipoprotein precursor (required for intercellular spreading of Shigella flexneri) (251 aa),fasta scores; opt: 310 z-score: 377.2 E(): 1e-13, 32.5% identity in 197 aa overlap. No Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF04333 VacJ like lipoprotein identitied within CDS. Further support given to product function. kept within product function. Functional classification - Pathogenicity; PMID:8145644; periplasmic protein 1308705 905664 Cj1371 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344759.1 1308007 D 192222 CDS YP_002344760.1 218562981 905665 1308715..1309284 1 NC_002163.1 Original (2000) note: Cj1372, probable periplasmic protein, len: 189 aa; similar to e.g. YRBC_ECOLI (211 aa),fasta scores; opt: 189 z-score: 222.3 E(): 4.4e-05, 22.5% identity in 200 aa overlap. No Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF05494 Toluene tolerance, Ttg2 identified within CDS. This family is a transporter which shows similarity to ABC transporters. No specific characterisation with acceptable identity score carried out yet, so kept within product function. Functional classification - Miscellaneous periplasmic proteins; PMID:9658016; periplasmic protein 1309284 905665 Cj1372 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344760.1 1308715 D 192222 CDS YP_002344761.1 218562982 905666 1309284..1311755 1 NC_002163.1 Original (2000) note: Cj1373, probable integral membrane protein, len: 823 aa; similar to hypothetical membrane proteins e.g. TR:O51268 (EMBL:AE001135) Borrelia burgdorferi conserved hypothetical integral membrane protein (767 aa), fasta scores; opt: 331 z-score: 348.2 E(): 4.2e-12, 24.8% identity in 840 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02460 Patched family protein identified within CDS. Prosite domain PS50156 SSD x2, Sterol-sensing 5TM box was also identified within CDS. Also, thirteen probable transmembrane helices predicted by TMHMM2.0. No specific characterisation carried out yet, so kept within product function. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 1311755 905666 Cj1373 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344761.1 1309284 D 192222 CDS YP_002344762.1 218562983 905667 complement(1311786..1312388) 1 NC_002163.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 1312388 905667 Cj1374c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 deoxyribonucleotide triphosphate pyrophosphatase YP_002344762.1 1311786 R 192222 CDS YP_002344763.1 218562984 905668 1312555..1313850 1 NC_002163.1 Original (2000) note: Cj1375, probable efflux protein, len: 431 aa; similar to members of the major facilitator family e.g. BMR1_BACSU multidrug resistance protein 1 (multidrug-efflux transporter 1) (389 aa), fasta scores; opt: 364 z-score: 415.1 E(): 8e-16, 27.1% identity in 384 aa overlap, and NORA_STAAU quinolone resistance NORA protein (388 aa), fasta scores; opt: 353 z-score: 402.8 E(): 3.9e-15, 26.7% identity in 375 aa overlap. 41.9% identity to HP1181. Also similar to Cj0035c (24.7% identity in 372 aa overlap). Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporters; Updated (2006) note: Pfam domain PF07690 Major Facilitator Superfamily identified within CDS. Prints motif also identified TCRTETA domain, Tetracycline resistance protein signature IPR001958. Also, eleven probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Product function further modified. No specific characterisation with acceptable identity score carried out yet, so kept within product function. Functional classification - Drug/analogue sensitivity; PMID:7961792; multidrug efflux transporter 1313850 905668 Cj1375 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 multidrug efflux transporter YP_002344763.1 1312555 D 192222 CDS YP_002344764.1 218562985 905669 1313847..1314656 1 NC_002163.1 Original (2000) note: Cj1376, probable periplasmic protein, len: 269 aa; similar to TR:O32102 (EMBL:Z99120) B. subtilis YUII protein (314 aa), fasta scores; opt: 209 z-score: 257.4 E(): 4.9e-07, 30.6% identity in 242 aa overlap, and TR:O54506 (EMBL:U97227) Salmonella enterica IROE (305 aa), fasta scores; opt: 195 z-score: 240.9 E(): 4.1e-06, 26.4% identity in 277 aa overlap. No Hp match. Contains probable N-terminal signal sequence. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 1314656 905669 Cj1376 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344764.1 1313847 D 192222 CDS YP_002344765.1 218562986 905670 complement(1314649..1316310) 1 NC_002163.1 Original (2000) note: Cj1377c, probable ferredoxin,len: 553 aa; limited similarity to e.g. HYCF_ECOLI formate hydrogenlyase subunit 6 (180 aa), fasta scores; opt: 212 z-score: 241.0 E(): 4e-06, 30.6% identity in 134 aa overlap. No Hp match. Contains PS00198 4Fe-4S ferredoxins,iron-sulfur binding region signature, and 2x Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet, so kept within product function. Functional classification - Energy metabolism - Electron transport; ferredoxin 1316310 905670 Cj1377c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ferredoxin YP_002344765.1 1314649 R 192222 CDS YP_002344766.1 218562987 905671 1316388..1317710 1 NC_002163.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 1317710 selA 905671 selA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 selenocysteine synthase YP_002344766.1 1316388 D 192222 CDS YP_002344767.1 218562988 905672 1317707..1319512 1 NC_002163.1 Original (2000) note: Cj1379, selB, probable selenocysteine-specific elongation factor, len: 601 aa; similar to e.g. SELB_ECOLI selenocysteine-specific elongation factor (614 aa), fasta scores; opt: 479 z-score: 491.6 E(): 4.4e-20, 26.2% identity in 362 aa overlap. No Hp ortholog. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family; Updated (2006) note: kept within product function as no characterisation with acceptable identity score has been carried out yet. Functional classification - Protein translation and modification; PMID:2140572, PMID:16511023; selenocysteine-specific elongation factor 1319512 selB 905672 selB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 selenocysteine-specific elongation factor YP_002344767.1 1317707 D 192222 CDS YP_002344768.1 218562989 905673 1319561..1320271 1 NC_002163.1 Original (2000) note: Cj1380, probable periplasmic protein, len: 236 aa; some similarity to e.g. DSBG_ECOLI thiol:disulfide interchange protein DSBG precursor (248 aa), fasta scores; opt: 138 z-score: 165.8 E(): 0.062,26.8% identity in 164 aa overlap (the active site is conserved). 34.1% identity to HP0231. Contains probable N-terminal signal sequence; Updated (2006) note: Paper identified linking protein to glycoprotein. Functional classification -Miscellaneous periplasmic proteins; PMID:12186869; periplasmic protein 1320271 905673 Cj1380 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344768.1 1319561 D 192222 CDS YP_002344769.1 218562990 905674 1320277..1320807 1 NC_002163.1 Original (2000) note: Cj1381, probable lipoprotein,len: 176 aa; no Hp match. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification - Membranes, lipoproteins and porins; lipoprotein 1320807 905674 Cj1381 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002344769.1 1320277 D 192222 CDS YP_002344770.1 218562991 905675 complement(1320852..1321343) 1 NC_002163.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 1321343 fldA 905675 fldA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flavodoxin FldA YP_002344770.1 1320852 R 192222 CDS YP_002344771.1 218562992 905676 complement(1321343..1322038) 1 NC_002163.1 Original (2000) note: Cj1383c, unknown, len: 231 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Literature search identified paper giving further clues to product function. Functional classification - Unknown; PMID:15231804; hypothetical protein 1322038 905676 Cj1383c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344771.1 1321343 R 192222 CDS YP_002344772.1 218562993 905677 complement(1322041..1322355) 1 NC_002163.1 Original (2000) note: Cj1384c, unknown, len: 104 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Literature search identified paper giving further clues to product function. Functional classification - Unknown; PMID:15231804; hypothetical protein 1322355 905677 Cj1384c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344772.1 1322041 R 192222 CDS YP_002344773.1 218562994 905678 1322526..1323950 1 NC_002163.1 Original (2000) note: Cj1385, katA, catalase, len: 474 aa; 98.5% identical to TR:Q59296 (EMBL:X85130) C. jejuni catalase (EC 1.11.1.6) (507 aa), and similar to e.g. CATA_BRUAB catalase (498 aa), fasta scores; opt: 2093 z-score: 2432.5 E(): 0, 65.6% identity in 474 aa overlap. 56.1% identity to HP0875. Contains PS00437 Catalase proximal heme-ligand signature, and Pfam match to entry PF00199 catalase; Updated (2006) note: Characterised within Campylobacter jejuni, so not added to product function. Functional classification - Detoxification; PMID:7670638; catalase 1323950 katA 905678 katA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 catalase YP_002344773.1 1322526 D 192222 CDS YP_002344774.1 218562995 905679 1324007..1324477 1 NC_002163.1 Original (2000) note: Cj1386, ankyrin-repeat containing protein, len: 412 aa; similar to proteins downstream of catalase in Pseudomonads e.g. TR:P95546 (EMBL:U16026) Pseudomonas syringae ANKF precursor (183 aa), fasta scores; opt: 217 z-score: 286.8 E(): 1.2e-08,31.3% identity in 134 aa overlap, and to eukaryotic ankyrin proteins e.g. ANK1_MOUSE ankyrin (1862 aa), fasta scores; opt: 181 z-score: 226.3 E(): 2.8e-05, 29.1% identity in 117 aa overlap. No Hp match. Also similar to Cj0834c (29.3% identity in 99 aa overlap). Contains 2x Pfam match to entry PF00023 ank, Ank repeat; Updated (2006) note: Literature search identified paper giving further clues to product function. Functional classification - Misc; PMID:15632442; ankyrin-repeat containing protein 1324477 905679 Cj1386 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ankyrin-repeat containing protein YP_002344774.1 1324007 D 192222 CDS YP_002344775.1 218562996 905680 complement(1324478..1325134) 1 NC_002163.1 Original (2000) note: Cj1387c, unknown, len: 218 aa; similar to hypothetical proteins e.g. YHEO_ECOLI (240 aa), fasta scores; opt: 164 z-score: 202.0 E(): 0.00063,29.4% identity in 204 aa overlap. No Hp match. Contains probable helix-turn-helix motif at aa 194-215 (Score 1100,+2.93 SD). Functional classification - Broad regulatory functions; hypothetical protein 1325134 905680 Cj1387c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344775.1 1324478 R 192222 CDS YP_002344776.1 218562997 905681 1325302..1325664 1 NC_002163.1 Original (2000) note: Cj1388, unknown, len: 120 aa; similar to prokaryotic hypothetical proteins e.g. YA28_PYRHO Pyrococcus horikoshii PHAL028 (137 aa), fasta scores; opt: 399 z-score: 503.4 E(): 1e-20, 53.8% identity in 117 aa overlap, and to e.g. UK14_HUMAN 14.5 KD translational inhibitor protein (137 aa), fasta scores; opt: 384 z-score: 485.1 E(): 1.1e-19, 48.3% identity in 116 aa overlap. 53.0% identity to HP0944. Also similar to Cj0327 (34.4% identity in 96 aa overlap). Contains Pfam match to entry PF01042 DUF10, Domain of unknown function; Updated (2006) note: Pfam domain PF01042 Endoribonuclease L-PSP identified within CDS. This domain is found in endoribonucleases, which are active on single-stranded mRNA and inhibit protein synthesis by cleavage of mRNA. Product modified to more specific family member based on motif results. No specific characterisation has been carried out yet, so kept within product function. Functional classification -DNA replication, restriction/modification, recombination and repair; endoribonuclease L-PSP 1325664 905681 Cj1388 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 endoribonuclease L-PSP YP_002344776.1 1325302 D 192222 CDS YP_002344777.1 218562998 5066043 1327120..1327257 1 NC_002163.1 Original (2000) note: Cj1392, metC', probable cystathionine beta-lyase, N-terminus, len: 348 aa; similar to many e.g. METC_HAEIN cystathionine beta-lyase (EC 4.4.1.8) (396 aa), fasta scores; opt: 88 z-score: 151.7 E(): 0.4, 45.2% identity in 42 aa overlap. No Hp match. Note that the rest of metC is in the downstream ORF Cj1393. This may represent a pseudogene fragment, or possibly programmed ribosomal frameshifting; Updated (2006) note: Gene names for Cj1392 and Cj1393 are identical with a ' denoting two separate terminals for the same CDS. May well be a pseudogene. kept within product function. Functional classification - Amino acid biosynthesis - Aspartate family; PMID:8831789; cystathionine beta-lyase, N-terminus 1327257 metC' 5066043 metC' Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cystathionine beta-lyase, N-terminus YP_002344777.1 1327120 D 192222 CDS YP_002344778.1 218562999 905683 1327236..1328282 1 NC_002163.1 Original (2000) note: Cj1393, metC', probable cystathionine beta-lyase, len: 348 aa; similar to many e.g. METC_ECOLI cystathionine beta-lyase (EC 4.4.1.8) (395 aa), fasta scores; opt: 802 z-score: 979.2 E(): 0, 35.6% identity in 354 aa overlap. 36.2% identity to HP0106. Also similar to Cj1727c, 30.0% identity in 363 aa overlap. Contains PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site, and Pfam match to entry PF01053 Cys_Met_Meta_PP, Gamma-family of PLP-dependent enzymes. Note that the N-terminal 50 aa of the protein appear to be in the upstream ORF Cj1392. This may represent a pseudogene fragment, or possibly programmed ribosomal frameshifting; Updated (2006) note: Gene names for Cj1392 and Cj1393 are identical with a ' denoting two separate terminals for the same CDS. May well be a pseudogene. kept in product function. Functional classification - Amino acid biosynthesis - Aspartate family; PMID:8831789; cystathionine beta-lyase 1328282 metC' 905683 metC' Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cystathionine beta-lyase YP_002344778.1 1327236 D 192222 CDS YP_002344779.1 218563000 905684 1328292..1329659 1 NC_002163.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1329659 905684 Cj1394 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 adenylosuccinate lyase YP_002344779.1 1328292 D 192222 CDS YP_002344780.1 218563001 905686 1331090..1331314 1 NC_002163.1 Original (2000) note: Cj1397, unknown, len: 74 aa; similar to hypothetical proteins e.g. TR:AAD06110 (EMBL:AE001486) H. pylori J99 JHP0533 (78 aa), fasta scores; opt: 143 z-score: 219.1 E(): 6.9e-05, 41.2% identity in 68 aa overlap, and TR:P73181 (EMBL:D90904) Synechocystis sp. ssr2333 (79 aa), fasta scores; opt: 94 z-score: 151.5 E(): 0.41, 28.6% identity in 77 aa overlap. Not predicted in TIGR Hp, but 38.8% identity to c(615977..616192); Updated (2006) note: Pfam domain PF04023 FeoA domain identified within CDS. This family of protein is thought to be involved in Fe2+ transport. Product modified to more specific family member based on motif search result. No characterisation has been carried out yet, so kept in product function. Functional classification - Transport/binding proteins - Cations; PMID:8407793; ferrous iron transport protein 1331314 905686 Cj1397 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ferrous iron transport protein YP_002344780.1 1331090 D 192222 CDS YP_002344781.1 218563002 905687 1331311..1333152 1 NC_002163.1 Original (2000) note: Cj1398, feoB, probable ferrous iron transport protein, len: 613 aa; similar to many e.g. FEOB_ECOLI ferrous iron transport protein B (773 aa), fasta scores; opt: 726 z-score: 805.2 E(): 0, 29.3% identity in 726 aa overlap. 50.5% identity to HP0687. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Pfam domains PF01926 GTPase of unknown function, PF02421 Ferrous iron transport protein B, PF07670 Nucleoside recognition, PF07664 Ferrous iron transport protein B C terminus and PF07670 Nucleoside recognition were all identified within CDS. Also, ten probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Some characterisation work within Campylobacter jejuni and Escherichia coli with acceptable identity scores. not added to product function. Functional classification -Transport/binding proteins - Cations; PMID:14735223, PMID:12446835; ferrous iron transport protein 1333152 feoB 905687 feoB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ferrous iron transport protein YP_002344781.1 1331311 D 192222 CDS YP_002344782.1 218563003 905688 complement(1333149..1334642) 1 NC_002163.1 Original (2000) note: Cj1399c, hydA2, probable Ni/Fe-hydrogenase small subunit, len: 497 aa; similar to e.g. MBHS_WOLSU quinone-reactive Ni/Fe-hydrogenase small chain (354 aa), fasta scores; opt: 1122 z-score: 1317.8 E(): 0, 52.6% identity in 285 aa overlap. No Hp ortholog. Also similar to Cj1267c (51.5% identity in 330 aa overlap). Contains C-terminal extension not present in other hydrogenase small subunits; Updated (2006) note: Pfam domain PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit identified within CDS. Further support given to product function. Characterised within Wolinella succinogenes, however,sequence alignment was only partial. Thus, kept within product function. Functional classification -Energy metabolism - Respiration; PMID:1587288; Ni/Fe-hydrogenase small subunit 1334642 hydA2 905688 hydA2 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Ni/Fe-hydrogenase small subunit YP_002344782.1 1333149 R 192222 CDS YP_002344783.1 218563004 905689 complement(1334646..1335470) 1 NC_002163.1 NADH; Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 1335470 fabI 905689 fabI Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 enoyl-(acyl carrier protein) reductase YP_002344783.1 1334646 R 192222 CDS YP_002344784.1 218563005 905690 complement(1335474..1336145) 1 NC_002163.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1336145 tpiA 905690 tpiA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 triosephosphate isomerase YP_002344784.1 1335474 R 192222 CDS YP_002344785.1 218563006 905691 complement(1336142..1337344) 1 NC_002163.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1337344 pgk 905691 pgk Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoglycerate kinase YP_002344785.1 1336142 R 192222 CDS YP_002344786.1 218563007 905692 complement(1337347..1338345) 1 NC_002163.1 Original (2000) note: Cj1403c, gapA, glyceraldehyde 3-phosphate dehydrogenase, len: 332 aa; similar to e.g. G3P1_BACSU glyceraldehyde 3-phosphate dehydrogenase 1 (334 aa), fasta scores; opt: 1070 z-score: 1216.4 E(): 0, 50.3% identity in 332 aa overlap. 45.6% identity to HP1346 and 46.7% identity to HP0921. Contains Pfam match to entry PF00044 gpdh, glyceraldehyde 3-phosphate dehydrogenases,and PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site; Updated (2006) note: Pfam domains PF02800 and PF00044 Glyceraldehyde 3-phosphate dehydrogenase,C-terminal and N-terminal were both identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with acceptable identity score. not added to product function. Functional classification - Energy metabolism - Glycolysis; PMID:10799476; glyceraldehyde 3-phosphate dehydrogenase 1338345 gapA 905692 gapA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glyceraldehyde 3-phosphate dehydrogenase YP_002344786.1 1337347 R 192222 CDS YP_002344787.1 218563008 905693 1338404..1338949 1 NC_002163.1 Original (2000) note: Cj1404, unknown, len: 181 aa; similar to hypothetical proteins e.g. YQEJ_BACSU (189 aa),fasta scores; opt: 305 z-score: 391.3 E(): 1.8e-14, 30.2% identity in 182 aa overlap. 40.4% identity to HP1337; Updated (2006) note: Pfam domain PF01467 Cytidylyltransferase identified within CDS. Product modified to more specific family member based on motif match. Characterised within Bacillus subtilis, however,identity scores were marginal. Thus, kept within product function. Functional classification - Misc; PMID:11704676, PMID:16153292; nicotinate-nucleotide adenylyltransferase 1338949 nadD 905693 nadD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 nicotinate-nucleotide adenylyltransferase YP_002344787.1 1338404 D 192222 CDS YP_002344788.1 218563009 905694 1338977..1339303 1 NC_002163.1 Original (2000) note: Cj1405, unknown, len: 108 aa; similar to hypothetical proteins e.g. YBEB_ECOLI (105 aa),fasta scores; opt: 185 z-score: 245.5 E(): 2.4e-06, 28.1% identity in 96 aa overlap. 51.4% identity to HP1414; Updated (2006) note: Pfam domain PF02410 Domain of unknown function DUF143 identified within CDS. Conserved added to product function. Functional classification -Conserved hypothetical proteins; hypothetical protein 1339303 905694 Cj1405 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344788.1 1338977 D 192222 CDS YP_002344789.1 218563010 905695 complement(1339362..1339712) 1 NC_002163.1 Original (2000) note: Cj1406c, probable periplasmic protein, len: 116 aa; similar to YQJC_ECOLI (predicted periplasmic protein) (127 aa), fasta scores; opt: 160 z-score: 185.2 E(): 0.0054 32.4% identity in 111 aa overlap. No Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF06476 Protein of unknown function (DUF1090) identified within CDS. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 1339712 905695 Cj1406c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344789.1 1339362 R 192222 CDS YP_002344790.1 218563011 905696 complement(1339759..1341147) 1 NC_002163.1 Original (2000) note: Cj1407c, probable phospho-sugar mutase, len: 462 aa; simial to e.g. ALGC_PSEAE phosphomannomutase (462 aa), fasta scores; opt: 1037 z-score: 1216.2 E(): 0, 40.7% identity in 457 aa overlap, and PGMU_NEIGO phosphoglucomutase (460 aa), fasta scores; opt: 884 z-score: 1037.2 E(): 0, 35.4% identity in 435 aa overlap. 44.7% identity to HP1275. Contains Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase and phosphomannomutase, and PS00017 ATP/GTP-binding site motif A (P-loop). Also similar to Cj0360 (28.8% identity in 386 aa overlap); Updated (2006) note: No specific characterisation with acceptable identity score identified. kept within product function. Functional classification -Central intermediary metabolism - General; PMID:11839312, PMID:8050998; phospho-sugar mutase 1341147 905696 Cj1407c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phospho-sugar mutase YP_002344790.1 1339759 R 192222 CDS YP_002344791.1 218563012 905697 1341250..1341786 1 NC_002163.1 interacts with the cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 1341786 fliL 905697 fliL Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar basal body-associated protein FliL YP_002344791.1 1341250 D 192222 CDS YP_002344792.1 218563013 905698 1341786..1342133 1 NC_002163.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1342133 acpS 905698 acpS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 4'-phosphopantetheinyl transferase YP_002344792.1 1341786 D 192222 CDS YP_002344793.1 218563014 905699 complement(1342134..1342553) 1 NC_002163.1 Original (2000) note: Cj1410c, possible membrane protein, len: 139 aa; no Hp match. Contains hydrophobic domain and PS00041 Bacterial regulatory proteins, araC family signature. Functional classification - Membranes,lipoproteins and porins; hypothetical protein 1342553 905699 Cj1410c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344793.1 1342134 R 192222 CDS YP_002344794.1 218563015 905700 complement(1342550..1343911) 1 NC_002163.1 Original (2000) note: Cj1411c, probable cytochrome P450, len: 453 aa; similar to many e.g. cytochrome P450 domain of CPXB_BACME cytochrome P450/NADPH-cytochrome P450 reductase (1048 aa), fasta scores; opt: 505 z-score: 578.8 E(): 6.4e-25, 28.3% identity in 407 aa overlap. No Hp match. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature, and Pfam match to entry PF00067 p450,Cytochrome P450; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification -Energy metabolism - Electron transport; PMID:9308178; cytochrome P450 1343911 905700 Cj1411c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cytochrome P450 YP_002344794.1 1342550 R 192222 CDS YP_002344795.1 218563016 905701 complement(1343908..1345029) 1 NC_002163.1 Original (2000) note: Cj1412c, probable integral membrane protein, len: 373 aa; no Hp match; Updated (2006) note: Three probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 1345029 905701 Cj1412c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344795.1 1343908 R 192222 CDS YP_002344796.1 218563017 905702 complement(1345102..1346286) 1 NC_002163.1 Original (2000) note: Cj1413c, possible polysaccharide modification protein, len: 394 aa; similar to e.g. LIPB_NEIME capsule polysaccharide modification protein (419 aa), fasta scores; opt: 744 z-score: 897.9 E(): 0, 38.5% identity in 395 aa overlap, and KSS5_ECOLI capsule polysaccharide export protein KPSS (389 aa), fasta scores; opt: 919 z-score: 1108.7 E(): 0, 40.2% identity in 383 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF05159 Capsule polysaccharide biosynthesis protein identified within CDS. Further support given to product function. Possible removed from product function as characterised within more than one genus with acceptable identity scores. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c -Cj1448c). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:8326861, PMID:8397187, PMID:10672176; capsule polysaccharide modification protein 1346286 kpsS 905702 kpsS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 capsule polysaccharide modification protein YP_002344796.1 1345102 R 192222 CDS YP_002344797.1 218563018 905703 complement(1346283..1348352) 1 NC_002163.1 Original (2000) note: Cj1414c, possible polysaccharide modification protein, len: 689 aa; similar to e.g. LIPA_NEIME capsule polysaccharide modification protein (400 aa), fasta scores; opt: 927 z-score: 1062.5 E(): 0, 39.6% identity in 394 aa overlap, and KSC5_ECOLI capsule polysaccharide export protein KPSC (675 aa), fasta scores; opt: 724 z-score: 827.0 E(): 0, 38.5% identity in 655 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF05159 Capsule polysaccharide biosynthesis protein identified within CDS. Further support given to product function. Possible removed from product function due to characterisation within more than one genus with acceptable identity scores. Literature search identified papers giving further clues to product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:8326861, PMID:8397187, PMID:15612919,PMID:10672176; capsule polysaccharide modification protein 1348352 kpsC 905703 kpsC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 capsule polysaccharide modification protein YP_002344797.1 1346283 R 192222 CDS YP_002344798.1 218563019 905704 complement(1348349..1348861) 1 NC_002163.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase 1348861 cysC 905704 cysC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 adenylylsulfate kinase YP_002344798.1 1348349 R 192222 CDS YP_002344799.1 218563020 905705 complement(1348851..1349612) 1 NC_002163.1 Original (2000) note: Cj1416c, probable sugar nucleotidyltransferase, len: 253 aa; similar to predicted nucleotidyltransferases e.g. TR:O29123 (EMBL:AE001025) Archaeoglobus fulgidus predicted glucose-1-phosphate cytidylyltransferase AF1142 (241 aa), fasta scores; opt: 252 z-score: 309.2 E(): 6.7e-10, 26.7% identity in 251 aa overlap. Also similar in part to LICC_HAEIN LICC protein (involved in LPS synthesis) (198 aa), fasta scores; opt: 209 z-score: 259.6 E(): 3.9e-07, 32.7% identity in 107 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase; Updated (2006) note: Specific characterisation still required, so kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:15612919, PMID:10672176; sugar nucleotidyltransferase 1349612 905705 Cj1416c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sugar nucleotidyltransferase YP_002344799.1 1348851 R 192222 CDS YP_002344800.1 218563021 905706 complement(1349614..1350216) 1 NC_002163.1 Original (2000) note: Cj1417c, unknown, len: 200 aa; some similarity to the C-terminus of carbamoyl-phosphate synthase small subunitss e.g. CARX_BACSU carbamoyl-phosphate synthase,arginine-specific, small chain (353 aa), fasta scores; opt: 134 z-score: 174.1 E(): 0.022, 27.3% identity in 99 aa overlap. No Hp ortholog; Updated (2006) note: Pfam domain PF00117, Glutamine amidotransferase class-I identified within CDS. Product function modified to more specific family member based on motif match. kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Misc; PMID:15612919, PMID:10672176; amidotransferase 1350216 905706 Cj1417c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amidotransferase YP_002344800.1 1349614 R 192222 CDS YP_002344801.1 218563022 905707 complement(1350207..1352546) 1 NC_002163.1 Original (2000) note: Cj1418c, unknown, len: 779 aa; weak similarity in part to several phosphoenolpyruvate synthases e.g. PPSA_STAMA probable phosphoenolpyruvate synthase (834 aa), fasta scores; opt: 166 z-score: 182.8 E(): 0.0074, 23.9% identity in 226 aa overlap. No Hp ortholog; Updated (2006) note: Interpro IPR008279,PEP-utilising enzyme, mobile region identified within CDS. Product modified to more specific family member. Similar to phosphoenolpyruvate synthase and pyruvate kinase in other bacteria with unnacceptable identity scores. kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Misc; PMID:15612919, PMID:10672176, PMID:2176881; hypothetical protein 1352546 905707 Cj1418c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344801.1 1350207 R 192222 CDS YP_002344802.1 218563023 905708 complement(1352561..1353322) 1 NC_002163.1 Original (2000) note: Cj1419c, possible methyltransferase, len: 253 aa; similar to hypothetical proteins e.g. TR:O53392 (EMBL:AL021841) Mycobacterium tuberculosis Rv3342 (MTV016.42) (243 aa), fasta scores; opt: 210 z-score: 250.1 E(): 1.3e-06, 32.0% identity in 122 aa overlap. Also contains weak similarity in part to several methyltransferases e.g. UBIE_ECOLI ubiquinone/menaquinone biosynthesis methyltransferase (251 aa), fasta scores; opt: 141 z-score: 171.3 E(): 0.032,24.2% identity in 132 aa overlap. No Hp match. Also similar to Cj1420c (33.7% identity in 255 aa overlap); Updated (2006) note: Running individual Pfam search identified PF08241 and PF08242 Methyltransferase domains. Further support given to product function. No specific characterisation carried out yet. Literature search identified papers giving further clues to product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Misc; PMID:15612919, PMID:10672176; methyltransferase 1353322 905708 Cj1419c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methyltransferase YP_002344802.1 1352561 R 192222 CDS YP_002344803.1 218563024 905709 complement(1353375..1354148) 1 NC_002163.1 Original (2000) note: Cj1420c, unknown, len: 258 aa; similar to hypothetical proteins e.g. TR:O53392 (EMBL:AL021841) Mycobacterium tuberculosis Rv3342 (MTV016.42) (243 aa), fasta scores; opt: 219 z-score: 263.3 E(): 2.4e-07, 30.7% identity in 137 aa overlap. Also similar to Cj1419c (34.1% identity in 255 aa overlap). Contains C(9-10) polymorphic region at aa 132. C9 (consensus) gives this ORF, C10 would give truncation after a further 19 aa; Updated (2006) note: Prostie domain PS00213 LIPOCALIN, Lipocalin signature identified within CDS. Conserved added to product function. Running individual Pfam search identified PF08241 and PF08242 Methyltransferase domains. Product modified to more specific family member based on motif search results. No specific characterisation has been carried out yet, so kept within product function. Literature search identified paper giving further clues to product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Misc; PMID:15612919, PMID:10672176; methyltransferase 1354148 905709 Cj1420c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methyltransferase YP_002344803.1 1353375 R 192222 CDS YP_002344804.1 218563025 905710 complement(1354215..1356053) 1 NC_002163.1 Original (2000) note: Cj1421c, possible sugar transferase, len: 612 aa; no Hp match. Similar to polymorphic tract-containing genes Cj1422c (overall 58.2% identity in 636 aa overlap, but N- and C-terminal 250 and 40 aa are identical), Cj0685c (28.0% identity in 404 aa overlap). N-terminus is simlar to parts of Cj1431c (38.6% identity in 114 aa overlap), and sugar transferases Cj1434c (39.6% identity in 111 aa overlap),and Cj1438c (34.6% identity in 127 aa overlap). Contains C(8-10) polymorphic tract at aa 30. C9 (consensus) gives this ORF, C8 gives truncation after +1 aa, C10 gives truncation after +5 aa. functional assignment is based on family clustering (BLASTP) with other C. jejuni predicted sugar transferases e.g. Cj1434c, and Cj1438c; Updated (2006) note: Identified within the Campylobacter jejuni Capsule locus (Cj1413c - Cj1448c). No specific characterisation has been carried out yet. kept within product function. Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15612919, PMID:10672176; sugar transferase 1356053 905710 Cj1421c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sugar transferase YP_002344804.1 1354215 R 192222 CDS YP_002344805.1 218563026 905711 complement(1356108..1357985) 1 NC_002163.1 Original (2000) note: Cj1422c, possible sugar transferase, len: 625 aa; no Hp match. Similar to polymorphic tract-containing genes Cj1421c (overall 58.2% identity in 636 aa overlap, but N- and C-terminal 250 and 40 aa are identical), Cj0685c (25.6% identity in 442 aa overlap). N-terminus is simlar to parts of Cj1431c (38.6% identity in 114 aa overlap), and sugar transferases Cj1434c (39.6% identity in 111 aa overlap),and Cj1438c (23.5% identity in 452 aa overlap). Contains C(9-10) polymorphic tract at aa 30. C9 (consensus) gives this ORF, C10 gives truncation after +5 aa. functional assignment is based on family clustering (BLASTP) with other C. jejuni predicted sugar transferases e.g. Cj1434c, and Cj1438c; Updated (2006) note: Prosite PS00221 MIP family signature identified within CDS. No specific characterisation has been carried out yet. kept within product function. Identified within the Campylobacter jejuni Capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15612919, PMID:10672176; sugar transferase 1357985 905711 Cj1422c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sugar transferase YP_002344805.1 1356108 R 192222 CDS YP_002344806.1 218563027 905712 complement(1358036..1358701) 1 NC_002163.1 Original (2000) note: Cj1423c, possible sugar-phosphate nucleotidyltransferase, len: 221 aa; similar to many predicted nucleotidyltransferases, e.g. TR:O58775 (EMBL:AP000004) Pyrococcus horikoshii hypothetical sugar-phosphate nucleotydyl transferase PH1022 (416 aa), fasta scores; opt: 413 z-score: 496.0 E(): 2.6e-20, 34.3% identity in 230 aa overlap, and MPG1_YEAST mannose-1-phosphate guanyltransferase (361 aa),fasta scores; opt: 258 z-score: 313.4 E(): 3.9e-10, 28.9% identity in 232 aa overlap. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. No Hp ortholog. Also similar to Cj1329 (35.6% identity in 216 aa overlap); Updated (2006) note: Some characterisation work carried out within Campylobacter jejuni. Product function modified to more specific family member. kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15612919, PMID:10672176; D-glycero-D-manno-heptose 1-phosphate guanosyltransferase 1358701 hddC 905712 hddC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 D-glycero-D-manno-heptose 1-phosphate guanosyltransferase YP_002344806.1 1358036 R 192222 CDS YP_002344807.1 218563028 905713 complement(1358689..1359294) 1 NC_002163.1 Original (2000) note: Cj1424c, gmhA2, probable phosphoheptose isomerase, len: 201 aa; similar to many e.g. LPCA_ECOLI phosphoheptose isomerase (EC 5.-.-.-) (192 aa), fasta scores; opt: 453 z-score: 548.7 E(): 3.1e-23,39.2% identity in 186 aa overlap. No Hp ortholog. Also similar to Cj1149c gmhA (57.8% identity in 147 aa overlap); Updated (2006) note: Pfam domain PF01380 SIS domain identified within CDS. Further support given to product function. Characterisation work carried out within Campylobacter jejuni and Escherichia coli, so removed from product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15612919, PMID:10672176, PMID:12101286; phosphoheptose isomerase 1359294 gmhA2 905713 gmhA2 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoheptose isomerase YP_002344807.1 1358689 R 192222 CDS YP_002344808.1 218563029 905714 complement(1359282..1360301) 1 NC_002163.1 Original (2000) note: Cj1425c, possible sugar kinase, len: 339 aa; similar to e.g. GAL1_LACHE galactokinase (388 aa), fasta scores; opt: 186 z-score: 227.6 E(): 2.4e-05, 24.3% identity in 371 aa overlap. Contains PS00012 Phosphopantetheine attachment site. No Hp match; Updated (2006) note: Pfam domain PF00288 GHMP kinases ATP-binding protein identified within CDS. Further support given to product function. Literature search identified work carried out within Campylobacter jejuni. Not yet fully characterised, so kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15612919, PMID:10672176; D-glycero-D-manno-heptose 7-phosphate kinase 1360301 hddA 905714 hddA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 D-glycero-D-manno-heptose 7-phosphate kinase YP_002344808.1 1359282 R 192222 CDS YP_002344809.1 218563030 905715 complement(1360321..1361172) 1 NC_002163.1 Original (2000) note: Cj1426c, unknown, len: 283 aa; no Hp match. Contains C(10-11) polymorphic region at aa 99. C10 (consensus) gives this ORF, C11 gives truncation after +8 aa; Updated (2006) note: TIGRFAM motif TIGR01444 Methyltransferase FkbM, identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out yet, so kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c -Cj1448c). Functional classification - Misc; PMID:15612919, PMID:10672176; methyltransferase family protein 1361172 905715 Cj1426c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methyltransferase family protein YP_002344809.1 1360321 R 192222 CDS YP_002344810.1 218563031 905716 complement(1361191..1362132) 1 NC_002163.1 Original (2000) note: Cj1427c, probable sugar-nucleotide epimerase/dehydratease, len: 313 aa; similar to many predicted epimerases/dehydrateases e.g. TR:Q25130 (EMBL:D25537) HALOCYNTHIA RORETZI (SEA SQUIRT) gene with similarity to UDPglucose4-epimerases and 3beta-hydroxysteroid dehydrogenase/isomerases HREPIB (241 aa), fasta scores; opt: 585 z-score: 691.2 E(): 3.5e-31,44.2% identity in 208 aa overlap, and TR:O73960 (EMBL:AP000002) Pyrococcus horikoshii hypothetical UDP-glucose 4-epimerase (318 aa), fasta scores; opt: 304 z-score: 361.7 E(): 7.9e-13, 26.4% identity in 326 aa overlap. No Hp ortholog; Updated (2006) note: Pfam domain PF01370 NAD dependent epimerase/dehydratase family identified within CDS. Further support given to product function. Literature search identified papers giving further information on product function. kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:15612919, PMID:10672176, PMID:9708982; sugar-nucleotide epimerase/dehydratease 1362132 905716 Cj1427c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sugar-nucleotide epimerase/dehydratease YP_002344810.1 1361191 R 192222 CDS YP_002344811.1 218563032 905717 complement(1362156..1363196) 1 NC_002163.1 Original (2000) note: Cj1428c, fcl, probable fucose synthetase, len: 346 aa; similar to e.g. FCL_ECOLI fucose synthetase (321 aa), fasta scores; opt: 562 z-score: 690.0 E(): 4.1e-31, 39.0% identity in 341 aa overlap. 29.6% identity to HP0045. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Pfam domain PF01370 NAD dependent epimerase/dehydratase family identified within CDS. Further support given to product function. Literature search identified papers giving further information on product function. Characterised within Escherichia coli with acceptable identity score. not added to product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15612919, PMID:10672176, PMID:11021971,PMID:9862812; GDP-L-fucose synthetase 1363196 fcl 905717 fcl Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 GDP-L-fucose synthetase YP_002344811.1 1362156 R 192222 CDS YP_002344812.1 218563033 905718 complement(1363196..1364122) 1 NC_002163.1 Original (2000) note: Cj1429c, unknown, len: 308 aa; no Hp match. Contains C(9-10) polymorphic region at aa 98. C10 (consensus) gives this ORF, C9 would give truncation after +1 aa; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Unknown; PMID:15612919, PMID:10672176; hypothetical protein 1364122 905718 Cj1429c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344812.1 1363196 R 192222 CDS YP_002344813.1 218563034 905719 complement(1364126..1364671) 1 NC_002163.1 Original (2000) note: Cj1430c, probable nucleotide-sugar epimerase/dehydratase, len: 181 aa; similar to e.g. RFBC_ECOLI DTDP-4-dehydrorhamnose 3,5-epimerase (185 aa), fasta scores; opt: 303 z-score: 386.2 E(): 3.4e-14, 33.9% identity in 165 aa overlap, and TR:Q46770 (EMBL:U23775) E. coli rmlC DTDP-6-deoxy-l-lyxo-4-hexulose reductase (183 aa), fasta scores; opt: 306 z-score: 390.0 E(): 2.1e-14, 33.5% identity in 164 aa overlap. No Hp match. Contains Pfam match to entry PF00908 dTDP_sugar_isom,dTDP-4-dehydrorhamnose 3,5-epimerase; Updated (2006) note: Pfam domain PF00908 dTDP-4-dehydrorhamnose 3,5-epimerase identified within CDS. Further support given to product function. Literature search identified papers giving further information on product function. Product function modified based on literature search information. Characterised within Escherichia coli with marginal identity score. kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15612919, PMID:10672176, PMID:7517390; dTDP-4-dehydrorhamnose 3,5-epimerase 1364671 rfbC 905719 rfbC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dTDP-4-dehydrorhamnose 3,5-epimerase YP_002344813.1 1364126 R 192222 CDS YP_002344814.1 218563035 905720 complement(1364671..1366419) 1 NC_002163.1 Original (2000) note: Cj1431c, unknown, len: 582 aa; no Hp match. Similar in part to N-termini of Cj1421c (38.6% identity in 114 aa overlap), and Cj1422c (38.6% identity in 114 aa overlap). Contains PS00455 AMP-binding domain signature; Updated (2006) note: Characterised within Campylobacter jejuni. Product modified to more specific family member based on literature search results. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:15612919; capsular polysaccharide heptosyltransferase 1366419 hddC 905720 hddC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 capsular polysaccharide heptosyltransferase YP_002344814.1 1364671 R 192222 CDS YP_002344815.1 218563036 905721 complement(1366422..1369517) 1 NC_002163.1 Original (2000) note: Cj1432c, possible sugar transferase, len: 1031 aa; weakly similar to e.g. TR:Q48232 (EMBL:X78559) Haemophilus influenzae orf3 in DNA for serotypE B capsulation locus (1215 aa), fasta scores; opt: 361 z-score: 398.4 E(): 7.2e-15, 22.8% identity in 1029 aa overlap, and TR:O84910 (EMBL:AF010183) glycosyltransferase WBPZ (381 aa), fasta scores; opt: 161 z-score: 182.7 E(): 0.0074, 23.1% identity in 251 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1. Also similar to Cj1434c (23.1% identity in 424 aa overlap); Updated (2006) note: Literature search identified papers giving further clues about product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:15612919, PMID:10672176; sugar transferase 1369517 905721 Cj1432c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sugar transferase YP_002344815.1 1366422 R 192222 CDS YP_002344816.1 218563037 905722 complement(1369527..1370633) 1 NC_002163.1 Original (2000) note: Cj1433c, unknown, len: 368 aa; no Hp match. Contains 9 repeats of the aa sequence KIDLNNT near the N-terminus; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Unknown; PMID:15612919, PMID:10672176; hypothetical protein 1370633 905722 Cj1433c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344816.1 1369527 R 192222 CDS YP_002344817.1 218563038 905723 complement(1370667..1372004) 1 NC_002163.1 Original (2000) note: Cj1434c, probable sugar transferase, len: 445 aa; similar in N-terminus to e.g. TR:O07340 (EMBL:O07340) Streptococcus pneumoniae SS-1,4-galactosyltransferase (318 aa), fasta scores; opt: 344 z-score: 405.7 E(): 2.8e-15, 27.3% identity in 326 aa overlap. No Hp ortholog. Highly similar to Cj1438c (72.4% identity in 456 aa overlap). Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; Updated (2006) note: No specific characterisation has been carried out yet, so kept within product function. Literature search identified papers giving further clues to product funciton. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15612919, PMID:10672176; sugar transferase 1372004 905723 Cj1434c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sugar transferase YP_002344817.1 1370667 R 192222 CDS YP_002344818.1 218563039 905724 complement(1372056..1372691) 1 NC_002163.1 Original (2000) note: Cj1435c, unknown, len: 211 aa; similar to TR:Q58989 (EMBL:U67599) Methanococcus jannaschii hypothetical protein MJ1594 (211 aa), fasta scores; opt: 177 z-score: 228.6 E(): 2.1e-05, 23.5% identity in 196 aa overlap. No Hp match; Updated (2006) note: TIGRFAM motifs identified HAD-superfamily proteins within CDS. Literature search identified paper giving further information to product function. Product function modified to more specific family member due to motif identification and literature search. Specific characterisation still required, so kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Misc; PMID:15612919, PMID:10672176; phosphatase 1372691 905724 Cj1435c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphatase YP_002344818.1 1372056 R 192222 CDS YP_002344819.1 218563040 905725 complement(1372695..1373867) 1 NC_002163.1 Original (2000) note: Cj1436c, probable aminotransferase, len: 390 aa; weakly similar to e.g. HIS8_BACSU histidinol-phosphate aminotransferase (360 aa),fasta scores; opt: 304 z-score: 351.9 E(): 2.8e-12, 25.5% identity in 318 aa overlap. No Hp match. Also similar to Cj0317 (hisC) (25.7% identity in 304 aa overlap), and Cj1437c (23.1% identity in 347 aa overlap). Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site; Updated (2006) note: Pfam domain PF00155 Aminotransferase class I and II identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with marginal identity score. removed from product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Misc; PMID:15612919, PMID:10672176; aminotransferase 1373867 905725 Cj1436c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aminotransferase YP_002344819.1 1372695 R 192222 CDS YP_002344820.1 218563041 905726 complement(1373917..1375020) 1 NC_002163.1 Original (2000) note: Cj1437c, probable aminotransferase, len: 367 aa; similar to e.g. HIS8_BACSU histidinol-phosphate aminotransferase (360 aa), fasta scores; opt: 408 z-score: 478.1 E(): 2.6e-19, 28.6% identity in 360 aa overlap. No Hp match. Also similar to Cj0317 (hisC) (29.9% identity in 344 aa overlap), and Cj1436c (23.3% identity in 347 aa overlap). Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II, and PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site; Updated (2006) note: Pfam domain PF00155 Aminotransferase class I and II identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with marginal identity score. Appropriate motifs present. removed from product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Misc; PMID:15612919, PMID:10672176; aminotransferase 1375020 905726 Cj1437c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 aminotransferase YP_002344820.1 1373917 R 192222 CDS YP_002344821.1 218563042 905727 complement(1375007..1377337) 1 NC_002163.1 Original (2000) note: Cj1438c, probable sugar transferase, len: 776 aa; similar in N-terminus to e.g. TR:O07340 (EMBL:O07340) Streptococcus pneumoniae SS-1,4-galactosyltransferase (318 aa), fasta scores; opt: 325 z-score: 375.2 E(): 1.4e-13, 26.9% identity in 316 aa overlap. Similar in C-terminus to TR:O31348 (EMBL:Y11138) Bacillus cereus hypothetical protein (ORF2) (300 aa),fasta scores; opt: 355 z-score: 409.9 E(): 1.7e-15, 31.2% identity in 340 aa overlap. 27.7% identity in 260 aa overlap to HP0102. Also highly similar to Cj1434c (72.9% identity in 457 aa overlap) in N-term, and similar to Cj1421c (34.6% identity in 127 aa overlap) and Cj1422c (23.5% identity in 452 aa overlap) in C-term. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; Updated (2006) note: Literature search identified paper giving further information on product function. Specific characterisation still required, so kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15612919, PMID:10672176; sugar transferase 1377337 905727 Cj1438c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sugar transferase YP_002344821.1 1375007 R 192222 CDS YP_002344822.1 218563043 905728 complement(1377339..1378445) 1 NC_002163.1 Original (2000) note: Cj1439c, glf, probable UDP-galactopyranose mutase, len: aa; highly simiar to e.g. TR:O86897 (EMBL:AJ006986) Streptococcus pneumoniae polysaccharide capsule bisynthesis cluster UDP-galactopyranose mutase (EC 5.4.99.9) (369 aa), fasta scores; opt: 1546 z-score: 1775.3 E(): 0, 59.9% identity in 364 aa overlap, and GLF_ECOLI UDP-galactopyranose mutase (EC 5.4.99.9) (367 aa), fasta scores; opt: 1545 z-score: 1774.2 E(): 0, 60.8% identity in 362 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03275 UDP-galactopyranose mutase identified within CDS. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. not added to product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:8576037, PMID:15947206, PMID:10672176; UDP-galactopyranose mutase 1378445 glf 905728 glf Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-galactopyranose mutase YP_002344822.1 1377339 R 192222 CDS YP_002344823.1 218563044 905729 complement(1378483..1379706) 1 NC_002163.1 Original (2000) note: Cj1440c, probable sugar transferase, len: 407 aa; similar in N-terminus to e.g. TR:O07340 (EMBL:O07340) Streptococcus pneumoniae SS-1,4-galactosyltransferase (318 aa), fasta scores; opt: 280 z-score: 326.2 E(): 7.5e-11, 26.7% identity in 374 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; Updated (2006) note: Literature search identified papers giving further information towards product function. Specific characterisation still required, so kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15612919, PMID:10672176, PMID:11422559; sugar transferase 1379706 905729 Cj1440c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sugar transferase YP_002344823.1 1378483 R 192222 CDS YP_002344824.1 218563045 905730 complement(1379716..1380897) 1 NC_002163.1 Original (2000) note: Cj1441c, kfiD, probable UDP-glucose 6-dehydrogenase, len: 393 aa; similar to many e.g. UDG5_ECOLI UDP-glucose 6-dehydrogenase (EC 1.1.1.22) (392 aa), fasta scores; opt: 1386 z-score: 1511.4 E(): 0,52.3% identity in 392 aa overlap. No Hp match. Contains Pfam match to entry PF00984 UDPG_MGDP_dh,UDP-glucose/GDP-mannose dehydrogenase family; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. removed from product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Central intermediary metabolism - Sugar nucleotides; PMID:12851388, PMID:9383197, PMID:7635844,PMID:12392544; UDP-glucose 6-dehydrogenase 1380897 kfiD 905730 kfiD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-glucose 6-dehydrogenase YP_002344824.1 1379716 R 192222 CDS YP_002344825.1 218563046 905731 complement(1380894..1382528) 1 NC_002163.1 Original (2000) note: Cj1442c, unknown, len: 544 aa; no Hp match; Updated (2006) note: Literature search identified papers giving further information about product function. Specific characterisation still required, so kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15612919, PMID:10672176, PMID:11422559; sugar transferase 1382528 905731 Cj1442c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sugar transferase YP_002344825.1 1380894 R 192222 CDS YP_002344826.1 218563047 905732 complement(1382528..1383475) 1 NC_002163.1 Original (2000) note: Cj1443c, kpsF, unknown, len: 315 aa; similar to hypothetical proteins belonging to the kpsF/gutQ family e.g. KSF1_ECOLI KPSF protein (317 aa),fasta scores; opt: 849 z-score: 979.3 E(): 0, 46.5% identity in 297 aa overlap. 38.7% identity to HP1429. Contains 2x Pfam match to entry PF00571 CBS, CBS domain; Updated (2006) note: Pfam domain PF01380 SIS domain identified within CDS. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. Product function modified to more specific family member. not added to product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:16390329, PMID:11956197, PMID:10672176; D-arabinose 5-phosphate isomerase 1383475 kpsF 905732 kpsF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 D-arabinose 5-phosphate isomerase YP_002344826.1 1382528 R 192222 CDS YP_002344827.1 218563048 905733 complement(1383486..1385144) 1 NC_002163.1 Original (2000) note: Cj1444c, kpsD, probable capsule polysaccharide export system periplasmic protein,len: aa; similar to e.g. KSD1_ECOLI polysialic acid transport protein KPSD PREC (558 aa), fasta scores; opt: 1187 z-score: 1306.9 E(): 0, 36.1% identity in 560 aa overlap. Contains probable N-terminal signal sequence. No Hp match; Updated (2006) note: Pfam domain PF02563 Polysaccharide biosynthesis/export protein identified within CDS. Paper identified linking protein to glycoprotein (PMID:Cj12186869). Characterised within Escherichia coli with acceptable identity score. removed from product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:12186869, PMID:8021185, PMID:16420360,PMID:10672176; capsule polysaccharide export system periplasmic protein 1385144 kpsD 905733 kpsD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 capsule polysaccharide export system periplasmic protein YP_002344827.1 1383486 R 192222 CDS YP_002344828.1 218563049 905734 complement(1385146..1386264) 1 NC_002163.1 Original (2000) note: Cj1445c, kpsE, probable capsule polysaccharide export system inner membrane protein, len: 372 aa; similar to e.g. KSE1_ECOLI capsule polysaccharide export inner-membrane protein (382 aa),fasta scores; opt: 752 z-score: 755.4 E(): 0, 34.2% identity in 351 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02706 Chain length determinant protein identified within CDS. Further support given to product function. Two probable transmembrane helices predicted by TMHMM2.0. Characterised within Escherichia coli with acceptable identity score. removed from product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:8253690, PMID:7868584, PMID:11467848,PMID:10672176; capsule polysaccharide export system inner membrane protein 1386264 kpsE 905734 kpsE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 capsule polysaccharide export system inner membrane protein YP_002344828.1 1385146 R 192222 CDS YP_002344829.1 218563050 905735 complement(1386264..1386926) 1 NC_002163.1 Original (2000) note: Cj1447c, kpsT, probable capsule polysaccharide export ATP-binding protein, len: 220 aa; identical to TR:O69286 (EMBL:AJ000856) C. jejuni ABC transporter protein (220 aa), and highly similar to e.g. KST1_ECOLI polysialic acid transport ATP-binding protein (219 aa), fasta scores; opt: 810 z-score: 945.3 E(): 0, 58.7% identity in 218 aa overlap. No Hp ortholog. Contains PS00017 ATP/GTP-binding site motif A (P-loop),PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran, ABC transporters; Updated (2006) note: Characterised within Campylobacter jejuni. removed from product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:12855177, PMID:9802032, PMID:10672176,PMID:11359581; capsule polysaccharide export ATP-binding protein 1386926 kpsT 905735 kpsT Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 capsule polysaccharide export ATP-binding protein YP_002344829.1 1386264 R 192222 CDS YP_002344830.1 218563051 905736 complement(1386923..1387705) 1 NC_002163.1 Original (2000) note: Cj1448c, kpsM, probable capsule polysaccharide export system inner membrane protein, len: 260 aa; identical to TR:O69285 (EMBL:AJ000856) C. jejuni ABC transporter protein (260 aa), and highly similar to e.g. KPM1_ECOLI polysialic acid transport protein KPSM (258 aa), fasta scores; opt: 488 z-score: 558.3 E(): 8.9e-24, 34.3% identity in 254 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF01061 ABC-2 type transporter identified within CDS. Further support given to product function. Also, six probable transmembrane helices predicted by TMHMM2.0. Characterised within Escherichia coli and Campylobacter jejuni with acceptable identity scores. not added to product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides, lipopolysaccharides and antigens; PMID:7715449, PMID:12855177, PMID:11500474,PMID:11359581, PMID:10672176, PMID:16436427; capsule polysaccharide export system inner membrane protein 1387705 kpsM 905736 kpsM Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 capsule polysaccharide export system inner membrane protein YP_002344830.1 1386923 R 192222 CDS YP_002344831.1 218563052 905737 complement(1387777..1388184) 1 NC_002163.1 Original (2000) note: Cj1449c, unknown, len: 135 aa; similar to YHBP_ECOLI hypothetical protein (147 aa),fasta scores; opt: 236 z-score: 315.0 E(): 3.2e-10, 30.5% identity in 131 aa overlap. No Hp match. Functional classification - Conserved hypothetical proteins; hypothetical protein 1388184 905737 Cj1449c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344831.1 1387777 R 192222 CDS YP_002344832.1 218563053 905738 1388259..1388822 1 NC_002163.1 Original (2000) note: Cj1450, probable ATP/GTP-binding protein, len: 187 aa; no Hp match. Contains PS00017 ATP/GTP-binding site motif A (P-loop),and probable coiled-coil domain at C-terminus (aa 150-175); Updated (2006) note: Literature search identified paper giving further clues to product function. Functional classification - Unknown; PMID:16740937; ATP/GTP-binding protein 1388822 905738 Cj1450 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP/GTP-binding protein YP_002344832.1 1388259 D 192222 CDS YP_002344833.1 218563054 905739 1388859..1389548 1 NC_002163.1 Original (2000) note: Cj1451, dut, possible dUTPase, len: 229 aa; similar to two enzymes of eukaryotic origin e.g. TR:O15826 (EMBL:L76742) Leishmania major characterised dUTPase (EC 3.6.1.23) (dUTP pyrophosphatase) (268 aa), fasta scores; opt: 311 z-score: 382.3 E(): 5.7e-14, 33.6% identity in 226 aa overlap, and TR:O15923 (EMBL:U93211) Trypanosoma cruzi deoxyuridine triphosphatase (283 aa), fasta scores; opt: 198 z-score: 246.6 E(): 2.1e-06, 32.9% identity in 228 aa overlap. No Hp match. C.j. does not have a homolog of the E. coli dut gene. H.p. has an E. coli-like dut gene; Updated (2006) note: Characterisation work carried out within Campylobacter jejuni. removed from product function. Functional classification -2'-deoxyribonucleotide biosynthesis; PMID:15364583; dUTPase 1389548 dut 905739 dut Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dUTPase YP_002344833.1 1388859 D 192222 CDS YP_002344834.1 218563055 905740 1389550..1390263 1 NC_002163.1 Original (2000) note: Cj1452, possible integral membrane protein, len: 237 aa; 29.7% identity to HP0174. Contains four large hydrophobic domains; Updated (2006) note: Pfam domain PF04401 Protein of unknown function (DUF540) identified within CDS. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 1390263 905740 Cj1452 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344834.1 1389550 D 192222 CDS YP_002344835.1 218563056 905741 complement(1390246..1391211) 1 NC_002163.1 Original (2000) note: Cj1453c, unknown, len: 321 aa; similar to hypothetical proteins e.g. YACA_BACSU (486 aa), fasta scores; opt: 290 z-score: 342.2 E(): 9.7e-12,26.8% identity in 257 aa overlap. 40.7% identity to HP0728; Updated (2006) note: Pfam domain PF01171 PP-loop family identified within CDS. Characterisation work has been carried out within Escherichia coli and Bacillus subtilis and has been designated as tRNA(Ile)-lysidine synthase. Product modified to more specific famlily member. Identity scores were marginal, so kept within product function. Functional classification -Aminoacyl tRNA synthetases and their modification; PMID:14527414, PMID:15894617, PMID:16039592; tRNA(Ile)-lysidine synthase 1391211 tilS 905741 tilS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tRNA(Ile)-lysidine synthase YP_002344835.1 1390246 R 192222 CDS YP_002344836.1 218563057 905742 complement(1391201..1392520) 1 NC_002163.1 Original (2000) note: Cj1454c, unknown, len: 439 aa; similar to hypothetical proteins e.g. YLIG_ECOLI (441 aa), fasta scores; opt: 671 z-score: 748.3 E(): 0, 34.2% identity in 433 aa overlap. 52.1% identity to HP0734. Also similar to Cj1006c (28.6% identity in 419 aa overlap), and Cj0458c (26.7% identity in 371 aa overlap). Contains PS01278 Uncharacterized protein family UPF0004 signature,and Pfam match to entry PF00919 UPF0004, Uncharacterized protein family UPF0004; Updated (2006) note: Pfam domain PF04055 Radical SAM superfamily identified within CDS. Product function modified to modified to more specific family member. No specific characterisation identified yet, so kept within product function. Functional classification - Misc; radical SAM domain family protein 1392520 905742 Cj1454c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 radical SAM domain family protein YP_002344836.1 1391201 R 192222 CDS YP_002344837.1 218563058 905743 1392594..1393691 1 NC_002163.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 1393691 prfB 905743 prfB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptide chain release factor 2 YP_002344837.1 1392594 D 192222 CDS YP_002344838.1 218563059 905744 complement(1393849..1394163) 1 NC_002163.1 Original (2000) note: Cj1456c, probable periplasmic protein, len: 104 aa; no Hp match. Contains possible N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1394163 905744 Cj1456c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344838.1 1393849 R 192222 CDS YP_002344839.1 218563060 905745 complement(1394285..1395403) 1 NC_002163.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 1395403 truD 905745 truD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 tRNA pseudouridine synthase D YP_002344839.1 1394285 R 192222 CDS YP_002344840.1 218563061 905746 complement(1395372..1396193) 1 NC_002163.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 1396193 thiL 905746 thiL Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 thiamine monophosphate kinase YP_002344840.1 1395372 R 192222 CDS YP_002344841.1 218563062 905747 1396280..1397353 1 NC_002163.1 Original (2000) note: Cj1459, unknown, len: 357 aa; 24.8% identity to HP0468. Functional classification -Conserved hypothetical proteins; hypothetical protein 1397353 905747 Cj1459 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344841.1 1396280 D 192222 CDS YP_002344842.1 218563063 905748 1397350..1397733 1 NC_002163.1 Original (2000) note: Cj1460, unknown, len: 127 aa; 41.0% identity to HP0811. Functional classification -Conserved hypothetical proteins; hypothetical protein 1397733 905748 Cj1460 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344842.1 1397350 D 192222 CDS YP_002344843.1 218563064 905749 1397726..1398409 1 NC_002163.1 Original (2000) note: Cj1461, possible DNA methylase, len: 227 aa; similar to hypothetical proteins e.g. YHHF_ECOLI (198 aa), fasta scores; opt: 186 z-score: 224.4 E(): 3.5e-05, 27.1% identity in 181 aa overlap. 37.2% identity to HP0810. Contains PS00092 N-6 Adenine-specific DNA methylases signature; Updated (2006) note: Pfam domain PF03602 Conserved hypothetical protein identified within CDS. Specific characterisation with acceptable identity score has not been carried out yet, so kept within product function. Functional classification - DNA replication,restriction/modification, recombination and repair; DNA methylase 1398409 905749 Cj1461 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA methylase YP_002344843.1 1397726 D 192222 CDS YP_002344844.1 218563065 905750 1398468..1399514 1 NC_002163.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 1399514 flgI 905750 flgI Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar basal body P-ring protein YP_002344844.1 1398468 D 192222 CDS YP_002344845.1 218563066 905751 1399514..1399855 1 NC_002163.1 Original (2000) note: Cj1463, unknown, len: 113 aa; 46.0% identity to HP0245; Updated (2006) note: Literature search identified papers giving clues to product function. C.Penn unpublished observation has predicted to be FlgJ. Functional classification - Conserved hypothetical proteins; PMID:14617189, PMID:14960570, PMID:15812042; hypothetical protein 1399855 flgJ 905751 flgJ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344845.1 1399514 D 192222 CDS YP_002344846.1 218563067 905752 1399918..1400115 1 NC_002163.1 Original (2000) note: Cj1464, unknown, len: 65 aa; no Hp match; Updated (2006) note: Literature search identified papers giving further clues to product function. Has been linked to flagellar anti FliA (sigma 28) factor FlgM protein. Functional classification - Unknown; PMID:14617189, PMID:14702320, PMID:14985343; hypothetical protein 1400115 flgM 905752 flgM Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344846.1 1399918 D 192222 CDS YP_002344847.1 218563068 905753 1400158..1400592 1 NC_002163.1 Original (2000) note: Cj1465, unknown, len: 144 aa; 31.9% identity to HP1120; Updated (2006) note: Literature search identified paper giving clues to product function. Product function linked to possible flagellar gene. Similar story for uncharacterised upstream genes Cj1463 and Cj1464. Functional classification - Conserved hypothetical proteins; PMID:14702320; hypothetical protein 1400592 905753 Cj1465 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344847.1 1400158 D 192222 CDS YP_002344848.1 218563069 905754 1400602..1402428 1 NC_002163.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1402428 flgK 905754 flgK Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar hook-associated protein FlgK YP_002344848.1 1400602 D 192222 CDS YP_002344849.1 218563070 905755 1402445..1403209 1 NC_002163.1 Original (2000) note: Cj1467, unknown, len: 254 aa; some similarity to TR:O51480 (EMBL:AE001154) Borrelia burgdorferi BB0530 (217 aa), fasta scores; opt: 331 z-score: 404.6 E(): 3.2e-15, 32.8% identity in 189 aa overlap. No Hp match. Functional classification -Conserved hypothetical proteins; hypothetical protein 1403209 905755 Cj1467 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344849.1 1402445 D 192222 CDS YP_002344850.1 218563071 905756 1403213..1403977 1 NC_002163.1 Original (2000) note: Cj1468, probable integral membrane protein, len: 254 aa; similar to hypothetical membrane proteins e.g. YFCA_ECOLI (269 aa), fasta scores; opt: 612 z-score: 731.5 E(): 0, 43.4% identity in 242 aa overlap. No Hp ortholog; Updated (2006) note: Pfam domain PF01925 Domain of unknown function DUF81 identified within CDS. Also, seven probable transmembrane helices predicted by TMHMM2.0. Furhter support given to product function. Functional classification - Membranes, lipoproteins and porins; integral membrane protein 1403977 905756 Cj1468 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344850.1 1403213 D 192222 CDS YP_002344851.1 218563072 905758 complement(1405147..1406706) 1 NC_002163.1 Original (2000) note: Cj1471c, probable type II protein secretion system E protein, len: 519 aa; similar to e.g. GSPE_ERWCA general secretion pathway protein E (498 aa), fasta scores; opt: 993 z-score: 1102.0 E(): 0,38.2% identity in 487 aa overlap, and HOFB_ECOLI protein transport protein HOFB (461 aa), fasta scores; opt: 925 z-score: 1027.3 E(): 0, 37.7% identity in 453 aa overlap. No Hp match. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00662 Bacterial type II secretion system protein E signature, and Pfam match to entry PF00437 GSPII_E, Bacterial type II secretion system protein; Updated (2006) note: Some characterisation in Campylobacter jejuni. New gene name designated. Similar to more than one genus with acceptable similarty scores. kept within product function. Functional classification - Protein and peptide secretion; PMID:12949093, PMID:1971619; type II protein secretion system E protein 1406706 ctsE 905758 ctsE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 type II protein secretion system E protein YP_002344851.1 1405147 R 192222 CDS YP_002344852.1 218563073 905759 complement(1406696..1407283) 1 NC_002163.1 Original (2000) note: Cj1472c, probable membrane protein, len: 195 aa; no Hp match; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Literature search identified paper giving further clues to product function. Functional classification - Membranes, lipoproteins and porins; PMID:12949093; hypothetical protein 1407283 905759 Cj1472c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344852.1 1406696 R 192222 CDS YP_002344853.1 218563074 905760 complement(1407287..1407895) 1 NC_002163.1 Original (2000) note: Cj1473c, probable ATP/GTP-binding protein, len: 202 aa; no Hp match. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Literature search identified paper giving further clues to product function. Functional classification - Unknown; PMID:12949093; ATP/GTP-binding protein 1407895 ctsP 905760 ctsP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP/GTP-binding protein YP_002344853.1 1407287 R 192222 CDS YP_002344854.1 218563075 905761 complement(1407888..1409306) 1 NC_002163.1 Original (2000) note: Cj1474c, probable type II protein secretion system D protein, len: 472 aa; similar to e.g. GSPD_PSEAE general secretion pathway protein D precursor (658 aa), fasta scores; opt: 305 z-score: 332.5 E(): 3.4e-11, 26.5% identity in 268 aa overlap. No Hp match. Contains Pfam match to entry PF00263 Bac_GSPproteins, Bacterial type II secretion system protein, and probable N-terminal signal sequence; Updated (2006) note: Pfam domains PF07655 Secretin N-terminal domain and PF07660 Secretin and TonB N terminus short domain were both identified within CDS. Literature search identified paper giving further clues to product function. kept within product function. Functional classification - Protein and peptide secretion; PMID:12949093; type II protein secretion system D protein 1409306 ctsD 905761 ctsD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 type II protein secretion system D protein YP_002344854.1 1407888 R 192222 CDS YP_002344855.1 218563076 905762 complement(1409278..1409595) 1 NC_002163.1 Original (2000) note: Cj1475c, unknown, len: 105 aa; no Hp match; Updated (2006) note: Literature search identified paper giving further clues to product function. Functional classification - Unknown; PMID:12949093; hypothetical protein 1409595 ctsR 905762 ctsR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344855.1 1409278 R 192222 CDS YP_002344856.1 218563077 905763 complement(1409619..1413179) 1 NC_002163.1 Original (2000) note: Cj1476c, probable pyruvate-flavodoxin oxidoreductase, len: 1186 aa; highly similar to many e.g. NIFJ_ECOLI probable pyruvate-flavodoxin oxidoreductase (1174 aa), fasta scores; opt: 3586 z-score: 3799.5 E(): 0, 47.2% identity in 1193 aa overlap. N-term has 28.6% identity to HP1110,C-term has 29.7% identity to HP1111. Contains 2x PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature,and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains; Updated (2006) note: Pfam domains PF02775 Thiamine pyrophosphate enzyme, C-terminal, PF01558 Pyruvate ferredoxin/flavodoxin oxidoreductase and PF01855 Pyruvate flavodoxin/ferredoxin oxidoreductase were all identified within CDS. Further support given to product function. Characterised in Escherichia coli with acceptable identity score. not added to product function. Functional classification - Energy metabolism - Electron transport; pyruvate-flavodoxin oxidoreductase 1413179 905763 Cj1476c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 pyruvate-flavodoxin oxidoreductase YP_002344856.1 1409619 R 192222 CDS YP_002344857.1 218563078 905764 complement(1413272..1413913) 1 NC_002163.1 Original (2000) note: Cj1477c, probable hydrolase,len: 206 aa; similar to e.g. GPH_ECOLI phosphoglycolate phosphatase (252 aa), fasta scores; opt: 209 z-score: 257.5 E(): 5.1e-07, 27.5% identity in 222 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase. Also similar to Cj1233 (27.3% identity in 205 aa overlap). No Hp match; Updated (2006) note: Similar to different types of hydrolases. kept within product function. Functional classification - Misc; PMID:12576589; hydrolase 1413913 905764 Cj1477c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hydrolase YP_002344857.1 1413272 R 192222 CDS YP_002344858.1 218563079 905765 complement(1413913..1414872) 1 NC_002163.1 Original (2000) note: Cj1478c, cadF, outer membrane fibronectin-binding protein, len: 319 aa; 82.8% identical to TR:O06895 (EMBL:U87559) C. jejuni CADF precursor (fibronectin-binding protein) (326 aa), and similar to many oprF proteins e.g. PORF_PSEFL outer membrane porin F precursor (root adhesin) (326 aa), fasta scores; opt: 401 z-score: 458.6 E(): 3.2e-18, 29.1% identity in 316 aa overlap. No Hp match. Contains PS01068 OmpA-like domain,and Pfam match to entry PF00691 OmpA, OmpA family; Updated (2006) note: Characterised within Campylobacter jejuni, so not added to product function. Functional classification - Pathogenicity; PMID:9220003, PMID:9435102, PMID:16091041; outer membrane fibronectin-binding protein 1414872 cadF 905765 cadF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 outer membrane fibronectin-binding protein YP_002344858.1 1413913 R 192222 CDS YP_002344859.1 218563080 905766 complement(1414997..1415386) 1 NC_002163.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 1415386 rpsI 905766 rpsI Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S9 YP_002344859.1 1414997 R 192222 CDS YP_002344860.1 218563081 905767 complement(1415389..1415814) 1 NC_002163.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 1415814 rplM 905767 rplM Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L13 YP_002344860.1 1415389 R 192222 CDS YP_002344861.1 218563082 905768 complement(1415898..1418663) 1 NC_002163.1 Original (2000) note: Cj1481c, possible helicase,len: 921 aa; weak similarity to several predicted helicases e.g. UVRD_MYCGE DNA helicase II homolog (703 aa), fasta scores; opt: 220 z-score: 237.1 E(): 7e-06, 24.5% identity in 715 aa overlap, and to e.g. ADDA_BACSU ATP-dependent nuclease subunit A (contains helicase activity) (1232 aa), fasta scores; opt: 204 z-score: 216.2 E(): 0.0001, 23.0% identity in 868 aa overlap. 30.5% identity to HP1553. Also similar to predicted helicases Cj1101 (23.9% identity in 532 aa overlap), and Cj0777 (24.1% identity in 673 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Pfam domain PF00580 UvrD/REP helicase identified within CDS. Further support given to product function. Not yet specifically characterised within related bacteria with acceptable identity score. Thus, kept within product function. Functional classification - DNA replication,restriction/modification, recombination and repair; recombination protein RecB 1418663 905768 Cj1481c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 recombination protein RecB YP_002344861.1 1415898 R 192222 CDS YP_002344862.1 218563083 905769 complement(1418660..1421026) 1 NC_002163.1 Original (2000) note: Cj1482c, unknown, len: 788 aa; 29.5% identity to HP1089. Functional classification -Conserved hypothetical proteins; hypothetical protein 1421026 905769 Cj1482c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344862.1 1418660 R 192222 CDS YP_002344863.1 218563084 905770 complement(1421023..1421544) 1 NC_002163.1 Original (2000) note: Cj1483c, probable lipoprotein, len: 173 aa; 30.8% identity (in N-term) to HP0150. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Functional classification - Membranes, lipoproteins and porins; lipoprotein 1421544 905770 Cj1483c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002344863.1 1421023 R 192222 CDS YP_002344864.1 218563085 905771 complement(1421531..1422133) 1 NC_002163.1 Original (2000) note: Cj1484c, probable membrane protein, len: 200 aa; no Hp match. Contains probable N-terminal signal sequence and probable C-terminal transmembrane domain. Functional classification -Membranes, lipoproteins and porins; hypothetical protein 1422133 905771 Cj1484c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344864.1 1421531 R 192222 CDS YP_002344865.1 218563086 905772 complement(1422130..1422231) 1 NC_002163.1 Original (2000) note: Cj1485c, probable periplasmic protein, len: 33 aa; no Hp match. Contains probable N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1422231 905772 Cj1485c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344865.1 1422130 R 192222 CDS YP_002344866.1 218563087 905773 complement(1422228..1422449) 1 NC_002163.1 Original (2000) note: Cj1486c, probable periplasmic protein, len: 73 aa; no Hp match. Contains probable N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1422449 905773 Cj1486c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344866.1 1422228 R 192222 CDS YP_002344867.1 218563088 905774 complement(1422446..1423309) 1 NC_002163.1 Original (2000) note: Cj1487c, ccoP, cb-type cytochrome C oxidase subunit III, len: 287 aa; simlar to TR:O87196 (EMBL:AB018105) H. pylori characterised cb-type cytochrome C oxidase subunit III (EC 1.9.3.1) (292 aa),fasta scores; opt: 952 z-score: 1043.8 E(): 0, 51.0% identity in 292 aa overlap (=HP0147, 51.2% identity). Contains 2x Pfam match to entry PF00034 cytochrome_c, and 2x PS00190 Cytochrome c family heme-binding site signature; Updated (2006) note: Characterised in Helicobacter pylori with acceptable identity score. not added to product function. Functional classification - Energy metabolism - Electron transport; PMID:9880817; cb-type cytochrome C oxidase subunit III 1423309 ccoP 905774 ccoP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cb-type cytochrome C oxidase subunit III YP_002344867.1 1422446 R 192222 CDS YP_002344868.1 218563089 905775 complement(1423309..1423572) 1 NC_002163.1 Original (2000) note: Cj1488c, ccoQ, cb-type cytochrome C oxidase subunit IV, len: 87 aa; similar to TR:O87195 (EMBL:AB018105) H. pylori characterised cb-type cytochrome C oxidase subunit IV (EC 1.9.3.1) (72 aa),fasta scores; opt: 143 z-score: 226.7 E(): 2.6e-05, 35.1% identity in 57 aa overlap (=HP0146); Updated (2006) note: Characterised in Helicobacter pylori with acceptable identity score. not added to product function. Functional classification - Energy metabolism - Electron transport; PMID:9880817; cb-type cytochrome C oxidase subunit IV 1423572 ccoQ 905775 ccoQ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cb-type cytochrome C oxidase subunit IV YP_002344868.1 1423309 R 192222 CDS YP_002344869.1 218563090 905776 complement(1423577..1424242) 1 NC_002163.1 CcoO; FixO; cbb3-type cytochrome c oxidase subunit II 1424242 ccoO 905776 ccoO Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cbb3-type cytochrome c oxidase subunit II YP_002344869.1 1423577 R 192222 CDS YP_002344870.1 218563091 905777 complement(1424255..1425721) 1 NC_002163.1 CcoN; FixN; cbb3-type cytochrome c oxidase subunit I 1425721 ccoN 905777 ccoN Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 cbb3-type cytochrome c oxidase subunit I YP_002344870.1 1424255 R 192222 CDS YP_002344871.1 218563092 905778 complement(1425847..1426527) 1 NC_002163.1 Original (2000) note: Cj1491c, probable two-component regulator, len: 226 aa; similar to many e.g. VANR_ENTFA regulatory protein VANRB (220 aa), fasta scores; opt: 322 z-score: 369.3 E(): 3e-13, 29.9% identity in 214 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain; Updated (2006) note: Pfam domain PF00486 Transcriptional regulatory protein, C terminal identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score has been carried out yet, so kept within product function. Functional classification - Signal transduction; two-component regulator 1426527 905778 Cj1491c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 two-component regulator YP_002344871.1 1425847 R 192222 CDS YP_002344872.1 218563093 905779 complement(1426530..1427741) 1 NC_002163.1 Original (2000) note: Cj1492c, probable two-component sensor, len: 403 aa; similar to many e.g. KINC_BACSU sporulation kinase C (428 aa), fasta scores; opt: 281 z-score: 301.1 E(): 1.9e-09, 29.3% identity in 242 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain; Updated (2006) note: No specific characterisation with acceptable identity score has been carried out yet,so kept within product function. Functional classification - Signal transduction; two-component sensor 1427741 905779 Cj1492c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 two-component sensor YP_002344872.1 1426530 R 192222 CDS YP_002344873.1 218563094 905783 complement(1427738..1428397) 1 NC_002163.1 Original (2000) note: Cj1493c, probable integral membrane protein, len: 219 aa; 33.9% identity to HP0861; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 1428397 905783 Cj1493c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344873.1 1427738 R 192222 CDS YP_002344874.1 218563095 905785 complement(1428394..1429512) 1 NC_002163.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1429512 carA 905785 carA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 carbamoyl phosphate synthase small subunit YP_002344874.1 1428394 R 192222 CDS YP_002344875.1 218563096 905784 complement(1429512..1430063) 1 NC_002163.1 Original (2000) note: Cj1495c, unknown, len: 183 aa; similar to hypothetical proteins e.g. TR:O67633 (EMBL:AE000754) Aquifex aeolicus AQ_1752 (183 aa), fasta scores; opt: 268 z-score: 310.8 E(): 5.4e-10, 24.6% identity in 183 aa overlap. 45.4% identity to HP1236; Updated (2006) note: Pfam domain PF04368 Protein of unknown function (DUF507) identified within CDS. Conserved added to product function. Functional classification -Conserved hypothetical proteins; hypothetical protein 1430063 905784 Cj1495c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344875.1 1429512 R 192222 CDS YP_002344876.1 218563097 906007 complement(1430156..1430674) 1 NC_002163.1 Original (2000) note: Cj1496c, probable periplasmic protein, len: 172 aa; similar to TR:O30719 (EMBL:AF016039) H. pylori PDP protein (HP0257) (223 aa), fasta scores; opt: 232 z-score: 243.0 E(): 3.3e-06, 33.3% identity in 177 aa overlap. Contains probable N-terminal signal sequence; Updated (2006) note: Paper identified linking protein to glycoprotein. Functional classification -Miscellaneous periplasmic proteins; PMID:12186869; periplasmic protein 1430674 906007 Cj1496c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344876.1 1430156 R 192222 CDS YP_002344877.1 218563098 905781 complement(1430667..1431095) 1 NC_002163.1 Original (2000) note: Cj1497c, unknown, len: 142 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 1431095 905781 Cj1497c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344877.1 1430667 R 192222 CDS YP_002344878.1 218563099 905786 complement(1431092..1432342) 1 NC_002163.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 1432342 purA 905786 purA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 adenylosuccinate synthetase YP_002344878.1 1431092 R 192222 CDS YP_002344879.1 218563100 905787 1432607..1433815 1 NC_002163.1 Original (2000) note: Cj1500, probable integral membrane protein, len: 402 aa; similar to hypothetical membrane protens e.g. YEDE_ECOLI (401 aa), fasta scores; opt: 722 z-score: 819.1 E(): 0, 44.3% identity in 395 aa overlap. No Hp match; Updated (2006) note: Pfam domain x2 PF04143 YeeE/YedE family (DUF395) identified within CDS. Also, ten probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Functional classification - Membranes, lipoproteins and porins; inner membrane protein 1433815 905787 Cj1500 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 inner membrane protein YP_002344879.1 1432607 D 192222 CDS YP_002344880.1 218563101 905791 1433819..1434046 1 NC_002163.1 Updated (2006) note: Conserved added to product function due to present motif within CDS; Original (2000) note: Cj1501, unknown, len: 85 aa; similar to hypothetical proteins e.g. YEDF_ECOLI (77 aa),fasta scores; opt: 341 z-score: 453.8 E(): 5.9e-18, 65.7% identity in 70 aa overlap. No Hp match. Contains PS01148 Uncharacterized protein family UPF0033 signature, and Pfam match to entry PF01206 UPF0033, Uncharacterized protein family UPF0033; hypothetical protein 1434046 905791 Cj1501 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344880.1 1433819 D 192222 CDS YP_002344881.1 218563102 905789 complement(1434062..1435549) 1 NC_002163.1 Original (2000) note: Cj1502c, putP, probable sodium/proline symporter, len: 495 aa; similar to many e.g. PUTP_ECOLI sodium/proline symporter (proline permease) (502 aa), fatsa scores; opt: 1695 z-score: 1986.4 E(): 0, 51.7% identity in 487 aa overlap. 74.9% identity to HP0055. Contains Pfam match to entry PF00474 SSF, Sodium:solute symporter family; Updated (2006) note: Twelve probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised within Escherichia coli with acceptable identity scores. kept within product function. Functional classification -Transport/binding proteins - Amino acids and amines; PMID:1567896, PMID:3302614; sodium/proline symporter 1435549 putP 905789 putP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sodium/proline symporter YP_002344881.1 1434062 R 192222 CDS YP_002344882.1 218563103 905792 complement(1435549..1439037) 1 NC_002163.1 Original (2000) note: Cj1503c, putA, possible proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase, len: 1162 aa; similar to e.g. PUTA_ECOLI bifunctional PUTA protein [includes: proline dehydrogenase (EC 1.5.99.8); delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12) (1320 aa), fasta scores; opt: 611 z-score: 639.8 E(): 2.6e-28, 26.9% identity in 892 aa overlap. 65.0% identity to HP0056. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase, PS00017 ATP/GTP-binding site motif A (P-loop), PS00687 Aldehyde dehydrogenases glutamic acid active site, and PS00070 Aldehyde dehydrogenases cysteine active site; Updated (2006) note: Pfam domain PF01619 Proline dehydrogenase also identified within CDS. Further support given to product function. Characterised within Escherichia coli, however, identity score was not acceptable. kept within product function. Functional classification - Degradation - Amino acids; PMID:15449943, PMID:7966312, PMID:12009917; proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase 1439037 putA 905792 putA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase YP_002344882.1 1435549 R 192222 CDS YP_002344883.1 218563104 905797 complement(1439168..1440094) 1 NC_002163.1 Original (2000) note: Cj1504c, selD, probable selenide,water dikinase, len: 308 aa; similar to e.g. SELD_ECOLI selenide,water dikinase (selenophosphate synthetase) (EC 2.7.9.3) (347 aa), fasta scores; opt: 638 z-score: 720.3 E(): 8.4e-33, 37.2% identity in 298 aa overlap. No Hp match. Contains Pfam match to entry PF00586 AIRS, AIR synthase related proteins; Updated (2006) note: Characterised wihtin Escherichia coli with acceptable identity score. kept within product function. Functional classification -Aminoacyl tRNA synthetases and their modification; PMID:2405383, PMID:1527085; selenide,water dikinase 1440094 selD 905797 selD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 selenide,water dikinase YP_002344883.1 1439168 R 192222 CDS YP_002344884.1 218563105 905793 complement(1440200..1440772) 1 NC_002163.1 Original (2000) note: Cj1505c, unknown, len: 190 aa; similar in N-term to hypothetical proteins e.g. Y990_METJA (75 aa), fasta scores; opt: 121 z-score: 164.1 E(): 0.081, 33.3% identity in 69 aa overlap. No Hp match. Some simlarity to Cj1492c (21.1% identity in 190 aa overlap). Contains Pfam match to entry PF01206 UPF0033,Uncharacterized protein family UPF0033; Updated (2006) note: Pfam domain PF01206 SirA-like protein identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation with acceptable identity score carried out yet, so kept within product function. Functional classification - Signal transduction; PMID:14645287; two-component response regulator 1440772 905793 Cj1505c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 two-component response regulator YP_002344884.1 1440200 R 192222 CDS YP_002344885.1 218563106 905796 complement(1440883..1442985) 1 NC_002163.1 Original (2000) note: Cj1506c, probable MCP-type signal transduction protein, len: 700 aa; similar to many e.g. TR:CAB38318 (EMBL:AJ132321) Halobacterium salinarium arginine chemotaxis CAR protein (452 aa), fasta scores; opt: 382 z-score: 382.7 E(): 5.4e-14, 29.9% identity in 281 aa overlap. Contains two possible transmembrane domains and Pfam match to entry PF00015 MCPsignal,Methyl-accepting chemotaxis protein (MCP) signaling domain. 35.3% identity to HP0099; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. kept in product function. Functional classification -Signal transduction; PMID:9750306; MCP-type signal transduction protein 1442985 905796 Cj1506c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MCP-type signal transduction protein YP_002344885.1 1440883 R 192222 CDS YP_002344886.1 218563107 905800 complement(1443095..1443832) 1 NC_002163.1 Original (2000) note: Cj1507c, unknown, len: 245 aa; no Hp match; Updated (2006) note: Pfam domain PF00126 Bacterial regulatory helix-turn-helix protein, lysR family identified within CDS. Product modified to more specific family based on motif match. No specific characterisation has been carried out yet, so kept within product function. Literature search identified paper giving further clues to product function. Functional classification - Broad regulatory functions; PMID:14641908; regulatory protein 1443832 905800 Cj1507c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 regulatory protein YP_002344886.1 1443095 R 192222 CDS YP_002344887.1 218563108 905799 complement(1443825..1444607) 1 NC_002163.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 1444607 fdhD 905799 fdhD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 formate dehydrogenase accessory protein YP_002344887.1 1443825 R 192222 CDS YP_002344888.1 218563109 905794 complement(1444774..1445706) 1 NC_002163.1 Original (2000) note: Cj1509c, fdhC, probable formate dehydrogenase, cytochrome B subunit, len: 310 aa; similar to e.g. TR:P28180 (EMBL:X54057) Wolinella succinogenes formate dehydrogenase C precursor (306 aa),fasta scores; opt: 634 z-score: 759.3 E(): 0, 42.8% identity in 318 aa overlap, and FDNI_ECOLI formate dehydrogenase, nitrate-inducible, cytochrome B556(fdn) subunit (217 aa), fasta scores; opt: 189 z-score: 234.3 E(): 9.9e-06, 25.5% identity in 212 aa overlap. No Hp ortholog; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Some characterisation in Wolinella succinogenes with acceptable identity score. kept in product function. Functional classification - Energy metabolism - Respiration -Anaerobic; PMID:9006048, PMID:1781728; formate dehydrogenase, cytochrom B subunit 1445706 fdhC 905794 fdhC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 formate dehydrogenase, cytochrom B subunit YP_002344888.1 1444774 R 192222 CDS YP_002344889.1 218563110 905790 complement(1445703..1446344) 1 NC_002163.1 Original (2000) note: Cj1510c, fdhB, probable formate dehydrogenase iron-sulfur subunit, len: 213 aa; similar to e.g. FDHB_WOLSU formate dehydrogenase iron-sulfur subunit (EC 1.2.1.2) (200 aa), fasta scores; opt: 1025 z-score: 1153.1 E(): 0, 69.5% identity in 197 aa overlap. No Hp ortholog. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature, and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains; Updated (2006) note: Some characterisation in Wolinella succinogenes with acceptable identity score. kept within product function. Functional classification - Energy metabolism - Respiration -Anaerobic; PMID:1781728, PMID:9006048; formate dehydrogenase iron-sulfur subunit 1446344 fdhB 905790 fdhB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 formate dehydrogenase iron-sulfur subunit YP_002344889.1 1445703 R 192222 CDS YP_002344890.1 218563111 905795 complement(1446341..1449145) 1 NC_002163.1 Original (2000) note: Cj1511c, fdhA, probable formate dehydrogenase large subunit, len: 934 aa; similar to e.g. TR:P28179 (EMBL:X54057) Wolinella succinogenes formate dehydrogenase large subunit precursor (EC 1.2.1.2)(939 aa), fasta scores; opt: 3368 z-score: 3913.9 E(): 7.3e-211, 52.8% identity in 930 aa overlap, and FDHF_ECOLI formate dehydrogenase H (EC 1.2.1.2) (formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide) (715 aa), fasta scores; opt: 813 z-score: 943.1 E(): 2.2e-45, 30.9% identity in 696 aa overlap. No Hp match. Contains Pfam match to entry PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases,and PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. Note that TGA codes for Selenocysteine at codon 181 complement(1448602..1448604); Updated (2006) note: Different characterisation in Escherichia coli and Wolinella succinogenes with acceptable identity scores to both. kept within product function. Functional classification - Energy metabolism - Respiration - Anaerobic; PMID:2941757, PMID:9036855, PMID:9006048; formate dehydrogenase large subunit 1449145 fdhA 905795 fdhA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 formate dehydrogenase large subunit YP_002344890.1 1446341 R 192222 CDS YP_002344891.1 218563112 905788 complement(1449145..1449336) 1 NC_002163.1 Original (2000) note: Cj1513c, possible periplasmic protein, len: 63 aa; no Hp match. Contains possible N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1449336 905788 Cj1513c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344891.1 1449145 R 192222 CDS YP_002344892.1 218563113 905802 complement(1449311..1450024) 1 NC_002163.1 Original (2000) note: Cj1514c, unknown, len: 237 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 1450024 905802 Cj1514c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344892.1 1449311 R 192222 CDS YP_002344893.1 218563114 905798 complement(1450328..1451476) 1 NC_002163.1 Original (2000) note: Cj1515c, probable decarboxylase, len: 382 aa; similar to TR:Q56575 (EMBL:D31783) Vibrio alginolyticus carboxynorspermidine decarboxylase (377 aa), fasta scores; opt: 667 z-score: 807.5 E(): 0, 36.6% identity in 380 aa overlap. 45.8% identity to HP0020; Updated (2006) note: Pfam domain PF00278 Pyridoxal-dependent decarboxylase, C-terminal identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet, so kept within product function. Functional classification - Misc; decarboxylase 1451476 905798 Cj1515c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 decarboxylase YP_002344893.1 1450328 R 192222 CDS YP_002344894.1 218563115 905803 1451600..1453141 1 NC_002163.1 Original (2000) note: Cj1516, probable periplasmic oxidoreductase, len: 1539 aa; similar to members of the multicoper oxidase family e.g. YACK_ECOLI probable blue-copper protein yack precursor (516 aa), fasta scores; opt: 376 z-score: 429.0 E(): 1.4e-16, 28.7% identity in 460 aa overlap, and BLRO_MYRVE bilirubin oxidase precursor (572 aa), fasta scores; opt: 309 z-score: 352.2 E(): 2.7e-12, 24.8% identity in 499 aa overlap. No Hp match. Contains possible N-terminal signal sequence, Pfam match to entry PF00394 Cu-oxidase, Multicopper oxidase, and PS00080 Multicopper oxidases signature 2; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet, so kept within product function. Functional classification - Misc; periplasmic oxidoreductase 1453141 905803 Cj1516 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic oxidoreductase YP_002344894.1 1451600 D 192222 CDS YP_002344895.1 218563116 905801 1453143..1453364 1 NC_002163.1 Original (2000) note: Cj1517, moaD, possible molybdopterin converting factor, subunit 1, len: 73 aa; similar to many predicted moaD genes, e.g. TR:O31706 (EMBL:AF012285) Bacillus subtilis molybdopterin converting factor (subunit 1) (77 aa), fasta scores; opt: 111 z-score: 167.7 E(): 0.051, 30.5% identity in 59 aa overlap, and weakly similar to MOAD_ECOLI molybdopterin [mpt] converting factor, subunit 1 (81 aa), fasta scores; opt: 81 z-score: 127.5 E(): 8.8, 38.5% identity in 26 aa overlap. 61.6% identity to HP0801; Updated (2006) note: Pfam domain PF02597 ThiS family identified within CDS. Further support given to product function. Specific characterisation with an acceptable similairty score has not been carried out yet,so kept within product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Molybdopterin; molybdopterin converting factor subunit 1 1453364 moaD 905801 moaD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molybdopterin converting factor subunit 1 YP_002344895.1 1453143 D 192222 CDS YP_002344896.1 218563117 905805 1453365..1453811 1 NC_002163.1 Original (2000) note: Cj1518, moaE, possible molybdopterin converting factor, subunit 2, len: 148 aa; similar to many predicted moaE genes, e.g. TR:O31705 (EMBL:AF012285) Bacillus subtilis molybdopterin converting factor (subunit 2) (157 aa), fasta scores; opt: 134 z-score: 182.4 E(): 0.0078, 25.2% identity in 131 aa overlap, and to MOAE_ECOLI molybdopterin [mpt] converting factor, subunit 2 (149 aa), fasta scores opt: 133 z-score: 181.4 E(): 0.0087, 26.0% identity in 123 aa overlap. 50.4% identity to HP0800; Updated (2006) note: Pfam domain PF02391 MoaE protein identified within CDS. Further support given to product function. Specific characterisation with acceptable similairty score has not been carried out yet,so kept within product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Molybdopterin; molybdopterin converting factor subunit 2 1453811 moaE 905805 moaE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molybdopterin converting factor subunit 2 YP_002344896.1 1453365 D 192222 CDS YP_002344897.1 218563118 905804 1453815..1455005 1 NC_002163.1 Original (2000) note: Cj1519, moeA2, probable molybdopterin biosynthesis protein, len: 396 aa; similar to e.g. MOEA_ECOLI molybdopterin biosynthesis MOEA protein (411 aa), fasta scores; opt: 541 z-score: 624.0 E(): 1.9e-27, 29.2% identity in 366 aa overlap. No Hp ortholog,but 37.3% identity to HP0172. Also similar to Cj0857c moeA (33.3% identity in 378 aa overlap). Contains Pfam match to entry PF00994 MoCF_biosynth, Molybdenum cofactor biosynthesis protein; Updated (2006) note: Pfam domains PF03453 MoeA N-terminal region (domain I and II), PF00994 Probable molybdopterin binding domain and PF03454 MoeA C-terminal region (domain IV) were all identified within CDS. Further support given to product function. Specific characterisation with acceptable similairty score has not been carried out yet, so kept within product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Molybdopterin; molybdopterin biosynthesis protein 1455005 moeA2 905804 moeA2 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 molybdopterin biosynthesis protein YP_002344897.1 1453815 D 192222 CDS YP_002344898.1 218563119 905810 complement(1455569..1456000) 1 NC_002163.1 Original (2000) note: Cj1521c, unknown, len: 143 aa; no Hp match; Updated (2006) note: Cj1521c,CJ1522c and Cj1523c are believed to be CRISPR-associated proteins that contribute to the CRISPR repeat region formation. Functional classification - Misc; PMID:11952905, PMID:16612537, PMID:16545108; CRISPR-associated protein 1456000 905810 Cj1521c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CRISPR-associated protein YP_002344898.1 1455569 R 192222 CDS YP_002344899.1 218563120 905808 complement(1455993..1456883) 1 NC_002163.1 Original (2000) note: Cj1522c, unknown, len: 296 aa; very weak simlarity to TR:O28401 (EMBL:AE000973) Archaeoglobus fulgidus AF1878 (345 aa), fasta scores; opt: 156 z-score: 198.5 E(): 0.00099, 25.3% identity in 281 aa overlap. No Hp match; Updated (2006) note: Cj1521c,CJ1522c and Cj1523c are believed to be CRISPR-associated proteins that contribute to the CRISPR repeat region formation. Functional classification - Misc; PMID:11952905, PMID:16612537, PMID:16545108; CRISPR-associated protein 1456883 905808 Cj1522c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CRISPR-associated protein YP_002344899.1 1455993 R 192222 CDS YP_002344900.1 218563121 905809 complement(1456880..1459834) 1 NC_002163.1 Original (2000) note: Cj1523c, unknown, len: 984 aa; no Hp match; Updated (2006) note: Cj1521c,CJ1522c and Cj1523c are believed to be CRISPR-associated proteins that contribute to the CRISPR repeat region formation. Functional classification - Misc; PMID:11952905, PMID:16612537, PMID:16545108; CRISPR-associated protein 1459834 905809 Cj1523c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CRISPR-associated protein YP_002344900.1 1456880 R 192222 CDS YP_002344901.1 218563122 905806 complement(1461504..1462493) 1 NC_002163.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 1462493 purM 905806 purM Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphoribosylaminoimidazole synthetase YP_002344901.1 1461504 R 192222 CDS YP_002344902.1 218563123 905813 1462554..1463159 1 NC_002163.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 1463159 coaE 905813 coaE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dephospho-CoA kinase YP_002344902.1 1462554 D 192222 CDS YP_002344903.1 218563124 905812 1463156..1463905 1 NC_002163.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 1463905 dapF 905812 dapF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 diaminopimelate epimerase YP_002344903.1 1463156 D 192222 CDS YP_002344904.1 218563125 905246 1463880..1464611 1 NC_002163.1 Original (2000) note: Cj1532, possible periplasmic protein, len: 243 aa; some similarity to N-terminus of BAX_ECOLI BAX protein (274 aa), fasta scores; opt: 240 z-score: 286.1 E(): 1.3e-08, 38.3% identity in 120 aa overlap. No Hp match. Contains possible N-terminal signal sequence; Updated (2006) note: Pfam domain PF01832 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (Glucosaminidase) identified within CDS. No specific characterisation carried out yet, so kept within product function. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1464611 905246 Cj1532 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344904.1 1463880 D 192222 CDS YP_002344905.1 218563126 905815 complement(1464608..1465645) 1 NC_002163.1 Original (2000) note: Cj1533c, unknown, len: 345 aa; 27.9% identity to HP1321. Contains possible helix-turn-helix motif at aa 191-212 (Score 1065, +2.81 SD). Functional classification - Broad regulatory functions; hypothetical protein 1465645 905815 Cj1533c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344905.1 1464608 R 192222 CDS YP_002344906.1 218563127 905816 complement(1465710..1466159) 1 NC_002163.1 Original (2000) note: Cj1534c, possible bacterioferritin, len: 149 aa; similar to many members of the DPS family e.g. NAPA_HELPY neutrophil-activating protein A (=HP0243) (bacterioferritin)(144 aa), fasta scores; opt: 397 z-score: 495.1 E(): 3e-20, 41.3% identity in 143 aa overlap, TPF1_TREPA antigen TPF1 (176 aa), fasta scores; opt: 296 z-score: 372.0 E(): 2.1e-13, 33.3% identity in 144 aa overlap, MRGA_BACSU metalloregulation DNA-binding stress protein (153 aa), fasta scores; opt: 234 z-score: 298.1 E(): 2.8e-09, 33.1% identity in 127 aa overlap, and FRI_LISIN non-heme iron-containing ferritin (156 aa), fasta scores; opt: 226 z-score: 288.3 E(): 9.8e-09, 31.8% identity in 148 aa overlap; Updated (2006) note: Pfam domain PF00210 Ferritin-like domain identified within CDS. Further support given to product function. kept within product function. Paper identified linking protein to glycoprotein (PMID:12186869). Functional classification -Transport/binding proteins - Cations; PMID:7883175, PMID:8709848, PMID:12186869; bacterioferritin 1466159 905816 Cj1534c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bacterioferritin YP_002344906.1 1465710 R 192222 CDS YP_002344907.1 218563128 905817 complement(1466289..1467509) 1 NC_002163.1 catalyzes the formation of D-fructose 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate isomerase 1467509 pgi 905817 pgi Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glucose-6-phosphate isomerase YP_002344907.1 1466289 R 192222 CDS YP_002344908.1 218563129 905818 complement(1467503..1468327) 1 NC_002163.1 Original (2000) note: Cj1536c, galU, probable UTP--glucose-1-phosphate uridylyltransferase, len: 274 aa; highly similar to many e.g. GALU_PSEAE UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (279 aa), fasta scores; opt: 1245 z-score: 1547.3 E(): 0,65.9% identity in 270 aa overlap. 61.3% identity to HP0646. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase; Updated (2006) note: Characterised in Pseudomonas aeruginosa with acceptable identity score. Thus, was not added to product function. Functional classification - Degradation - Carbon compounds; PMID:8169209; UTP-glucose-1-phosphate uridylyltransferase 1468327 galU 905818 galU Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UTP-glucose-1-phosphate uridylyltransferase YP_002344908.1 1467503 R 192222 CDS YP_002344909.1 218563130 905819 complement(1468409..1470382) 1 NC_002163.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 1470382 acs 905819 acs Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetyl-CoA synthetase YP_002344909.1 1468409 R 192222 CDS YP_002344910.1 218563131 905820 complement(1470520..1471515) 1 NC_002163.1 Original (2000) note: Cj1538c, possible anion-uptake ABC-transport system ATP-binding protein,len: 331 aa; similar to many e.g. LACK_AGRRD lactose transport ATP-binding protein LACK (363 aa), fasta scores; opt: 319 z-score: 386.4 E(): 3.3e-14, 28.8% identity in 208 aa overlap, and UGPC_ECOLI SN-glycerol-3-phosphate transport ATP-binding protein (356 aa), fasta scores; opt: 298 z-score: 361.6 E(): 8.1e-13, 32.1% identity in 196 aa overlap. No Hp ortholog. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran, ABC transporters. identification as anion-uptake is due to similarities of associated permease Cj1539c; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. kept in product function. Functional classification -Transport/binding proteins - Anions; anion-uptake ABC-transport system ATP-binding protein 1471515 905820 Cj1538c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 anion-uptake ABC-transport system ATP-binding protein YP_002344910.1 1470520 R 192222 CDS YP_002344911.1 218563132 905821 complement(1471517..1472236) 1 NC_002163.1 Original (2000) note: Cj1539c, possible anion-uptake ABC-transport system permease, len: 239 aa; similar to many involved in anion uptake e.g. CYST_ECOLI sulfate transport system permease (277 aa), fasta scores; opt: 235 z-score: 293.7 E(): 4.9e-09,23.6% identity in 220 aa overlap, and MODB_ECOLI molybdenum transport system permease proteim (229 aa),fasta scores; opt: 201 z-score: 253.9 E(): 8.1e-07, 25.2% identity in 214 aa overlap. No Hp otholog; Updated (2006) note: Pfam domain PF00528 Binding-protein-dependent transport system inner membrane component identified within CDS. Also, five probable transmembrane helices predicted by TMHMM2.0. No specific characterisation with acceptable identity score, so kept within product function. Functional classification - Transport/binding proteins - Anions; anion-uptake ABC-transport system permease 1472236 905821 Cj1539c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 anion-uptake ABC-transport system permease YP_002344911.1 1471517 R 192222 CDS YP_002344912.1 218563133 905822 1472282..1473091 1 NC_002163.1 Original (2000) note: Cj1540, probable periplasmic protein, len: 269 aa; similar to TR:O26579 (EMBL:AE000832) Methanobacterium thermoautotrophicum MTH479 (293 aa),fasta scores; opt: 416 z-score: 475.8 E(): 3.5e-19, 37.0% identity in 273 aa overlap. No Hp match. Contains probable N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1473091 905822 Cj1540 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344912.1 1472282 D 192222 CDS YP_002344913.1 218563134 905823 1473233..1474000 1 NC_002163.1 Original (2000) note: Cj1541, unknown, len: 255 aa; similar to hypothetical proteins e.g. YCSF_BACSU (211 aa),fasta scores; opt: 736 z-score: 875.7 E(): 0, 59.9% identity in 177 aa overlap, and to LAMB_EMENI Aspergillus nidulans lactam utilization protein LAMB (262 aa), fasta scores; opt: 405 z-score: 485.4 E(): 1e-19, 44.9% identity in 127 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03746 LamB/YcsF family identified within CDS. No specific characterisation has been carried out yet, so kept within product function. Functional classification - Conserved hypothetical proteins; LamB/YcsF family protein 1474000 905823 Cj1541 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 LamB/YcsF family protein YP_002344913.1 1473233 D 192222 CDS YP_002344914.1 218563135 905826 1474010..1474750 1 NC_002163.1 Original (2000) note: Cj1542, unknown, len: 246 aa; similar to hypothetical proteins e.g. YCSJ_BACSU (578 aa),fasta scores; opt: 569 z-score: 690.1 E(): 4.1e-31, 41.8% identity in 237 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02682 Allophanate hydrolase subunit 1 identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out yet, so kept within product function. Also,similarity to Bacillus subtilis kinase a inhibitor (sporulation inhibitor kipi) (PMID:9334321). Functional classification - Degradation - Carbon compounds; PMID:9334321; allophanate hydrolase subunit 1 1474750 905826 Cj1542 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 allophanate hydrolase subunit 1 YP_002344914.1 1474010 D 192222 CDS YP_002344915.1 218563136 905824 1474731..1475696 1 NC_002163.1 Original (2000) note: Cj1543, unknown, len: 321 aa; similar to hypothetical proteins e.g. YBGK_ECOLI (310 aa),fasta scores; opt: 553 z-score: 652.4 E(): 5.1e-29, 32.7% identity in 312 aa overlap. Also similar to part of DUR1_YEAST urea amidolyase [includes: urea carboxylase; allophanate hydrolase] (1835 aa), fasta scores; opt: 307 z-score: 353.8 E(): 2.2e-12, 28.5% identity in 333 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02626 Allophanate hydrolase subunit 2 identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out yet, so kept within product function. Functional classification - Degradation - Carbon compounds; allophanate hydrolase subunit 2 1475696 905824 Cj1543 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 allophanate hydrolase subunit 2 YP_002344915.1 1474731 D 192222 CDS YP_002344916.1 218563137 905162 complement(1475693..1476589) 1 NC_002163.1 Original (2000) note: Cj1544c, probable integral membrane protein, len: 298 aa; simlar to hypothetical membrane proteins e.g. YYAM_BACSU (305 aa), fasta scores; opt: 244 z-score: 300.4 E(): 2.1e-09, 22.3% identity in 300 aa overlap. No Hp match. Contains Pfam match to entry PF00892 DUF6, Integral membrane protein; Updated (2006) note: Ten probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; integral membrane protein 1476589 905162 Cj1544c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002344916.1 1475693 R 192222 CDS YP_002344917.1 218563138 904498 complement(1476622..1477200) 1 NC_002163.1 Original (2000) note: Cj1545c, unknown, len: 192 aa; similar to e.g. MDAB_ECOLI modulator of drug activity B (193 aa), fasta scores; opt: 777 z-score: 934.0 E(): 0,57.8% identity in 192 aa overlap. Also weak simlarity to many boxidoreductases e.g. YCAK_ECOLI NAD(P)H oxidoreductase YCAK (196 aa), fasta scores; opt: 124 z-score: 159.3 E(): 0.15, 24.7% identity in 174 aa overlap. 65.1% identity to HP0630; Updated (2006) note: Pfam domain PF02525 Flavodoxin-like fold identified within CDS. Further support given to product function. Homolog designation kept within product function. Functional classification -Conserved hypothetical proteins; MdaB protein 1477200 904498 Cj1545c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MdaB protein YP_002344917.1 1476622 R 192222 CDS YP_002344918.1 218563139 905827 1477300..1477647 1 NC_002163.1 Original (2000) note: Cj1546, unknown, len: 115 aa; similar to hypothetical proteins e.g. YYBR_BACSU (125 aa),fasta scores; opt: 278 z-score: 389.5 E(): 2.3e-14, 42.5% identity in 106 aa overlap. No Hp match. Also similar to Cj1556 (43.6% identity in 101 aa overlap); Updated (2006) note: Pfam domain PF01638 Transcriptional regulator identified within CDS. Product modified to more specific family member based on motif match. kept within product function. Functional classification - Broad regulatory functions; transcriptional regulator 1477647 905827 Cj1546 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcriptional regulator YP_002344918.1 1477300 D 192222 CDS YP_002344919.1 218563140 904541 1477635..1478084 1 NC_002163.1 Original (2000) note: Cj1547, unknown, len: 149 aa; similar to e.g. BLC_ECOLI outer membrane lipoprotein BLC precursor (177 aa), fasta scores; opt: 230 z-score: 307.6 E(): 8.2e-10, 27.6% identity in 145 aa overlap, and APD_MOUSE apolipoprotein D precursor (189 aa), fasta scores; opt: 151 z-score: 206.3 E(): 0.00036, 30.3% identity in 145 aa overlap. No Hp match. Contains PS00213 Lipocalin signature, but no N-terminal signal sequence. Functional classification - Conserved hypothetical proteins; Blc protein 1478084 904541 Cj1547 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Blc protein YP_002344919.1 1477635 D 192222 CDS YP_002344920.1 218563141 904495 complement(1478086..1479162) 1 NC_002163.1 Original (2000) note: Cj1548c, probable NADP-dependent alcohol dehydrogenase, len: 358 aa; similar to e.g. ADH_MYCTU NADP-dependent alcohol dehydrogenase (EC 1.1.1.2) (346 aa), fasta scores; opt: 997 z-score: 1095.7 E(): 0, 43.9% identity in 344 aa overlap. Also similar to plant lignin production alcohol dehydrogenases e.g. CAD3_ARATH cinnamyl-alcohol dehydrogenase ELI3-2 (359 aa),fasta scores; opt: 949 z-score: 1043.1 E(): 0, 40.9% identity in 352 aa overlap. 65.8% identity to HP1104. Contains PS00059 Zinc-containing alcohol dehydrogenases signature, and Pfam match to entry PF00107 adh_zinc,Zinc-binding dehydrogenases; Updated (2006) note: kept within product function as acceptable identity score to more than one characterised bacteria. Functional classification - Misc; PMID:1427101; NADP-dependent alcohol dehydrogenase 1479162 904495 Cj1548c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NADP-dependent alcohol dehydrogenase YP_002344920.1 1478086 R 192222 CDS YP_002344921.1 218563142 905828 complement(1479390..1482485) 1 NC_002163.1 Original (2000) note: Cj1549c, probable type I restriction enzyme R protein, len: 1031 aa; similar to many e.g. T1R1_ECOLI type I restriction enzyme EcoR124II R protein (EC 3.1.21.3) (1033 aa), fasta scores; opt: 353 z-score: 372.8 E(): 1.9e-13, 23.5% identity in 1047 aa overlap. 26.4% identity to HP1402; Updated (2006) note: Pfam domains PF04851 Type III restriction enzyme, res subunit and PF04313 Type I restriction enzyme R protein N terminal were both identified within CDS. Literature search identified work carried out in Campylobacter jejuni. This CDS is the start of a type I locus (genes Cj1549-Cj1553). Some characterisation work within Escherichia coli, however, kept within product function as identity score was unnacceptable. Functional classification - DNA replication, restriction/modification, recombination and repair; PMID:15699185, PMID:9016588; type I restriction enzyme R protein 1482485 hsdR 905828 hsdR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 type I restriction enzyme R protein YP_002344921.1 1479390 R 192222 CDS YP_002344922.1 218563143 905829 complement(1482488..1484254) 1 NC_002163.1 Original (2000) note: Cj1550c, probable ATP/GTP-binding protein, len: 588 aa; some similarity to hypothetical proteins e.g. TR:O50349 Lactobacillus helveticus plasmid plh1 hypothetical protein (495 aa),fasta scores; opt: 209 z-score: 231.6 E(): 1.4e-05, 22.6% identity in 412 aa overlap. No Hp match. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Prosite domain PS50893 ABC_TRANSPORTER_2, ATP-binding cassette, ABC transporter-type domain profile identified within CDS. Literature search identified work carried out within Helicobacter pylori and Campylobacter jejuni. This CDS is within a type I locus (genes Cj1549-Cj1553). kept within product function. Functional classification - Conserved hypothetical proteins; PMID:15699185; ATP/GTP-binding protein 1484254 rloH 905829 rloH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP/GTP-binding protein YP_002344922.1 1482488 R 192222 CDS YP_002344923.1 218563144 905830 complement(1484265..1485407) 1 NC_002163.1 Original (2000) note: Cj1551c, probable type I restriction enzyme S protein, len: 588 aa; simlar to many e.g. T1S_SALTY type I restriction enzymE StySJI specificity protein (S protein) (469 aa), fasta scores; opt: 173 z-score: 199.9 E(): 0.00082, 25.6% identity in 301 aa overlap. 24.1% identity to HP0462; Updated (2006) note: Literature search identified work carried out within Helicobacter pylori and Campylobacter jejuni. This CDS is within a type I locus (genes Cj1549-Cj1553). Some characterisation work within Escherichia coli, however, kept within product function as identity scores were unnacceptable. Functional classification - DNA replication,restriction/modification, recombination and repair; PMID:15699185, PMID:3025838, PMID:1453962; type I restriction enzyme S protein 1485407 hsdS 905830 hsdS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 type I restriction enzyme S protein YP_002344923.1 1484265 R 192222 CDS YP_002344924.1 218563145 905831 complement(1485626..1487092) 1 NC_002163.1 Original (2000) note: Cj1552c, unknown, len: 488 aa; no Hp match; Updated (2006) note: Pfam domain PF04326 Divergent AAA domain identified within CDS. Conserved added to product function. Literature search identified work carried out within Helicobacter pylori and Campylobacter jejuni. This CDS is within a type I locus (genes Cj1549-Cj1553). Functional classification - Unknown; PMID:15699185; hypothetical protein 1487092 mloB 905831 mloB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344924.1 1485626 R 192222 CDS YP_002344925.1 218563146 905832 complement(1487089..1488591) 1 NC_002163.1 Original (2000) note: Cj1553c, probable type I restriction enzyme M protein, len: 500 aa; simlar to many e.g. T1M1_ECOLI type I restriction enzyme EcoR124II M protein (EC 2.1.1.72) (520 aa), fasta scores; opt: 447 z-score: 527.4 E(): 4.7e-22, 25.9% identity in 521 aa overlap. 30.2% identity to HP0850. Contains PS00092 N-6 Adenine-specific DNA methylases signature; Updated (2006) note: Pfam domains PF02384 N-6 DNA Methylase and PF02506 Type I restriction modification system were identified within CDS. Further support given to product function. Literature search identified work carried out within Helicobacter pylori and Campylobacter jejuni. This CDS is within a type I locus (genes Cj1549-Cj1553). Some characterisation work within Escherichia coli, however, kept within product function as identity scores were unnacceptable. Functional classification - DNA replication,restriction/modification, recombination and repair; PMID:15699185, PMID:8145241, PMID:9016588; type I restriction enzyme M protein 1488591 hsdM 905832 hsdM Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 type I restriction enzyme M protein YP_002344925.1 1487089 R 192222 CDS YP_002344926.1 218563147 905833 complement(1488961..1489596) 1 NC_002163.1 Original (2000) note: Cj1555c, unknown, len: 211 aa; similar to TR:P71037 Bacillus subtilis YWNB (213 aa),fasta scores; opt: 519 z-score: 635.5 E(): 4.5e-28, 42.9% identity in 212 aa overlap. No Hp match. Functional classification - Conserved hypothetical proteins; hypothetical protein 1489596 905833 Cj1555c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344926.1 1488961 R 192222 CDS YP_002344927.1 218563148 905834 1489789..1490121 1 NC_002163.1 Original (2000) note: Cj1556, unknown, len: 110 aa; similar to hypothetical proteins e.g. YYBR_BACSU (125 aa),fasta scores; opt: 307 z-score: 402.3 E(): 4.3e-15, 43.7% identity in 103 aa overlap. No Hp match. Also similar to Cj1546 (43.6% identity in 101 aa overlap); Updated (2006) note: Pfam domain PF01638 Transcriptional regulator identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out yet, so kept within product function. Functional classification - Broad regulatory functions; transcriptional regulator 1490121 905834 Cj1556 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcriptional regulator YP_002344927.1 1489789 D 192222 CDS YP_002344928.1 218563149 905835 1490206..1490379 1 NC_002163.1 Original (2000) note: Cj1558, probable membrane protein, len: 57 aa; no Hp match. May constitute the 5' end of Cj1560, which may be a pseudogene; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; hypothetical protein 1490379 905835 Cj1558 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344928.1 1490206 D 192222 CDS YP_002344930.1 218563150 905837 1491162..1491341 1 NC_002163.1 Original (2000) note: Cj1561, probable transcriptional regulator, len: 59 aa; similar to N-terminus of e.g. ARR1_ECOLI arsenical resistance operon repressor (117 aa), fasta scores; opt: 142 z-score: 236.5 E(): 7.4e-06, 38.2% identity in 55 aa overlap, and CADC_LISMO cadmium efflux system accessory protein (119 aa), fasta scores; opt: 134 z-score: 224.1 E(): 3.7e-05,42.0% identity in 50 aa overlap. No Hp match. Contains helix-turn-helix motif at aa 30-51 (Score 1478, +4.22 SD); Updated (2006) note: Similar to more than one characterised bacteria. designation kept within product function. Functional classification - Broad regulatory functions; transcriptional regulator 1491341 905837 Cj1561 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcriptional regulator YP_002344930.1 1491162 D 192222 CDS YP_002344931.1 218563151 905838 1491332..1491484 1 NC_002163.1 Original (2000) note: Cj1562, unknown, len: 50 aa; no Hp match. Functional classification - Unknown; hypothetical protein 1491484 905838 Cj1562 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344931.1 1491332 D 192222 CDS YP_002344932.1 218563152 904355 complement(1491492..1491923) 1 NC_002163.1 Original (2000) note: Cj1563c, probable transcriptional regulator, len: 143 aa; similar to members of the MerR family e.g. Y186_HAEIN hypothetical transcriptional regulator HI0186 (135 aa), fasta scores; opt: 241 z-score: 290.6 E(): 7.3e-09, 31.9% identity in 119 aa overlap, and BLTR_BACSU multidrug-efflux transporter 2 regulator (273 aa), fasta scores; opt: 149 z-score: 182.1 E(): 0.008, 24.4% identity in 127 aa overlap. No Hp match. Contains helix-turn-helix motif at aa 4-25 (Score 1172, +3.18 SD); Updated (2006) note: Pfam domain PF00376 MerR family regulatory protein identified within CDS. Further support given to product function. No specific characterisation has been carried out with acceptable identity score, so kept within product function. Functional classification - Broad regulatory functions; transcriptional regulator 1491923 904355 Cj1563c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transcriptional regulator YP_002344932.1 1491492 R 192222 CDS YP_002344933.1 218563153 904333 1492003..1493991 1 NC_002163.1 Original (2000) note: Cj1564, probable methyl-accepting chemotaxis signal transduction protein,len: 662 aa; similar to many e.g. TLPC_BACSU methyl-accepting chemotaxis protein TLPC (573 aa), fasta scores; opt: 351 z-score: 363.6 E(): 6.2e-13, 26.2% identity in 553 aa overlap. No Hp ortholog. C-terminus contains repeat1, and is identical to the other repeat 1-containing genes Cj0262c and Cj0144. Contains N-terminal signal sequence and transmembrane anchor around aa 300. Also contains Pfam match to entry PF00015 MCPsignal,Methyl-accepting chemotaxis protein (MCP) signaling domain; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Characterisation work carried out within Bacillus subtilis, however, identity scores were marginal. kept within product function. Functional classification - Chemotaxis and mobility; PMID:6213619, PMID:7921238; methyl-accepting chemotaxis signal transduction protein 1493991 904333 Cj1564 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methyl-accepting chemotaxis signal transduction protein YP_002344933.1 1492003 D 192222 CDS YP_002344934.1 218563154 905864 complement(1494034..1496400) 1 NC_002163.1 Original (2000) note: Cj1565c, pflA, required for flagellar function, len: 788 aa; identical to TR:Q46092 (EMBL:U09019) C. jejuni pflA (788 aa). 22.7% identity to HP1274. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF07719 Tetratricopeptide repeat identified within CDS. Similar to previously characterised PflA protein in Campylobacter jejuni. Paper identified linking protein to glycoprotein. Functional classification - Surface structures; PMID:7715450, PMID:12186869; paralysed flagellum protein 1496400 pflA 905864 pflA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 paralysed flagellum protein YP_002344934.1 1494034 R 192222 CDS YP_002344935.1 218563155 905839 complement(1496422..1497810) 1 NC_002163.1 Original (2000) note: Cj1566c, nuoN, probable NADH dehydrogenase I chain N, len: 462 aa; similar to many e.g. NUON_ECOLI NADH dehydrogenase I chain N (EC 1.6.5.3) (425 aa), fasta scores; opt: 592 z-score: 716.4 E(): 1.4e-32,32.3% identity in 402 aa overlap. 35.3% identity to HP1273. Contains Pfam match to entry PF00361 oxidored_q1,NADH-Ubiquinone/plastoquinone (complex I), various chains; Updated (2006) note: Characterised operon within Escherichia coli. Appropriate motifs also present. Identity score was acceptable, so not added to product function. Twelve probable transmembrane helices predicted by TMHMM2.0. Functional classification - Energy metabolism - Respiration - Aerobic; PMID:7565112, PMID:7730262, PMID:15368583,PMID:12718520; NADH dehydrogenase I chain N 1497810 nuoN 905839 nuoN Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NADH dehydrogenase I chain N YP_002344935.1 1496422 R 192222 CDS YP_002344936.1 218563156 905840 complement(1497800..1499287) 1 NC_002163.1 Original (2000) note: Cj1567c, nuoM, probable NADH dehydrogenase I chain M, len: 495 aa; similar to many e.g. NU4M_CHOCR NADH-ubiquinone oxidoreductase chain 4 (EC 1.6.5.3) (492 aa), fasta scores; opt: 1055 z-score: 1213.7 E(): 0, 36.4% identity in 495 aa overlap, and NUOM_ECOLI NADH dehydrogenase I chain M(EC 1.6.5.3) (509 aa), blastp scores; E= 1.5e-58, 32% identity in 419 aa overlap. 40.1% identity to HP1272. Contains Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I),various chains; Updated (2006) note: Characterised operon within Escherichia coli. Appropriate motifs present. Identity score was acceptable, so not added to product function. Fourteen probable transmembrane helices predicted by TMHMM2.0. Functional classification - Energy metabolism - Respiration - Aerobic; PMID:7565112, PMID:7730262, PMID:15368583,PMID:12923180; NADH dehydrogenase I chain M 1499287 nuoM 905840 nuoM Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NADH dehydrogenase I chain M YP_002344936.1 1497800 R 192222 CDS YP_002344937.1 218563157 905250 complement(1499289..1501079) 1 NC_002163.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 1501079 nuoL 905250 nuoL Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NADH dehydrogenase subunit L YP_002344937.1 1499289 R 192222 CDS YP_002344938.1 218563158 904491 complement(1501081..1501377) 1 NC_002163.1 Original (2000) note: Cj1569c, nuoK, probable NADH dehydrogenase I chain K, len: 98 aa; similar to many e.g. NUOK_ECOLI NADH dehydrogenase I chain K (EC 1.6.5.3) (100 aa), fasta scores; opt: 212 z-score: 302.0 E(): 1.7e-09,32.6% identity in 95 aa overlap. 45.8% identity to HP1270. Contains Pfam match to entry PF00420 oxidored_q2,NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Updated (2006) note: Characterised operon within Escherichia coli. Appropriate motifs present. Identity score was acceptable, so not added to product function. Three probable transmembrane helices predicted by TMHMM2.0. Functional classification - Energy metabolism - Respiration - Aerobic; PMID:7565112, PMID:7730262, PMID:15368583,PMID:15996109; NADH dehydrogenase I chain K 1501377 nuoK 904491 nuoK Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NADH dehydrogenase I chain K YP_002344938.1 1501081 R 192222 CDS YP_002344939.1 218563159 905841 complement(1501374..1501892) 1 NC_002163.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 1501892 nuoJ 905841 nuoJ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NADH dehydrogenase subunit J YP_002344939.1 1501374 R 192222 CDS YP_002344940.1 218563160 905842 complement(1501889..1502530) 1 NC_002163.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 1502530 nuoI 905842 nuoI Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NADH dehydrogenase subunit I YP_002344940.1 1501889 R 192222 CDS YP_002344941.1 218563161 905843 complement(1502540..1503538) 1 NC_002163.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 1503538 nuoH 905843 nuoH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NADH dehydrogenase subunit H YP_002344941.1 1502540 R 192222 CDS YP_002344942.1 218563162 905177 complement(1503531..1505993) 1 NC_002163.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit G 1505993 nuoG 905177 nuoG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NADH dehydrogenase subunit G YP_002344942.1 1503531 R 192222 CDS YP_002344943.1 218563163 905844 complement(1505990..1506682) 1 NC_002163.1 Original (2000) note: Cj1574c, unknown, len: 230 aa; 26.5% identity to HP1265. Functional classification -Conserved hypothetical proteins; hypothetical protein 1506682 905844 Cj1574c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344943.1 1505990 R 192222 CDS YP_002344944.1 218563164 905845 complement(1506679..1506906) 1 NC_002163.1 Original (2000) note: Cj1575c, unknown, len: 75 aa; 52.0% identity to HP1264. Functional classification -Conserved hypothetical proteins; hypothetical protein 1506906 905845 Cj1575c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344944.1 1506679 R 192222 CDS YP_002344945.1 218563165 905846 complement(1506903..1508129) 1 NC_002163.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 1508129 nuoD 905846 nuoD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NADH dehydrogenase subunit D YP_002344945.1 1506903 R 192222 CDS YP_002344946.1 218563166 905847 complement(1508131..1508925) 1 NC_002163.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit C 1508925 nuoC 905847 nuoC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NADH dehydrogenase subunit C YP_002344946.1 1508131 R 192222 CDS YP_002344947.1 218563167 905848 complement(1508922..1509425) 1 NC_002163.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 1509425 nuoB 905848 nuoB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NADH dehydrogenase subunit B YP_002344947.1 1508922 R 192222 CDS YP_002344948.1 218563168 905849 complement(1509407..1509796) 1 NC_002163.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit A 1509796 nuoA 905849 nuoA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NADH dehydrogenase subunit A YP_002344948.1 1509407 R 192222 CDS YP_002344949.1 218563169 905850 complement(1509909..1510574) 1 NC_002163.1 Original (2000) note: Cj1580c, probable peptide ABC-transport system ATP-binding protein, len: 221 aa; similar to e.g. DPPF_ECOLI dipeptide transport ATP-binding protein (334 aa), fasta scores; opt: 436 z-score: 498.1 E(): 2e-20, 34.8% identity in 210 aa overlap, and APPF_BACSU oligopeptide transport ATP-binding protein (329 aa), fasta scores; opt: 419 z-score: 479.2 E(): 2.3e-19,30.8% identity in 211 aa overlap. 30.6% identity to HP0302. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran, ABC transporters; Updated (2006) note: Similar to different transport systems with acceptable identity scores. kept within product function. Functional classification -Transport/binding proteins - Other; peptide ABC transporter ATP-binding protein 1510574 905850 Cj1580c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptide ABC transporter ATP-binding protein YP_002344949.1 1509909 R 192222 CDS YP_002344950.1 218563170 905851 complement(1510567..1511277) 1 NC_002163.1 Original (2000) note: Cj1581c, probable peptide ABC-transport system ATP-binding protein, len: 236 aa; similar to e.g. OPPD_ECOLI oligopeptide transport ATP-binding protein (337 aa), fasta scores opt: 385 z-score: 442.8 E(): 2.4e-17, 31.5% identity in 232 aa overlap. 29.8% identity to HP0301. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran, ABC transporters; Updated (2006) note: Similar to different transport systems with acceptable identity scores. kept within product function. Functional classification -Transport/binding proteins - Other; peptide ABC transporter ATP-binding protein 1511277 905851 Cj1581c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptide ABC transporter ATP-binding protein YP_002344950.1 1510567 R 192222 CDS YP_002344951.1 218563171 905852 complement(1511274..1512068) 1 NC_002163.1 Original (2000) note: Cj1582c, probable peptide ABC-transport system permease, len: 264 aa; similar to e.g. PPC_BACSU oligopeptide transport permease (303 aa), fasta scores; opt: 397 z-score: 467.3 E(): 1e-18, 29.1% identity in 261 aa overlap. 26.3% identity to HP0300. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Similar to different transport systems with acceptable identity scores. kept within product function. Functional classification - Transport/binding proteins - Other; PMID:16045618; peptide ABC transporter permease 1512068 905852 Cj1582c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptide ABC transporter permease YP_002344951.1 1511274 R 192222 CDS YP_002344952.1 218563172 905853 complement(1512055..1512999) 1 NC_002163.1 Original (2000) note: Cj1583c, probable peptide ABC-transport system permease, len: 314 aa; similar to e.g. OPPB_LACLC oligopeptide transport system permease (319 aa), fasta scores; opt: 476 z-score: 540.7 E(): 8.5e-23, 28.4% identity in 317 aa overlap. 24.1% identity to HP0299; Updated (2006) note: Six probable transmembrane helices predicted by TMHMM2.0. Pfam domain PF00528 Binding-protein-dependent transport system inner membrane component identified within CDS. Similar to different transport systems with acceptable identity scores. kept within product function. Functional classification - Transport/binding proteins - Other; peptide ABC transporter permease 1512999 905853 Cj1583c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptide ABC transporter permease YP_002344952.1 1512055 R 192222 CDS YP_002344953.1 218563173 905854 complement(1512999..1514534) 1 NC_002163.1 Original (2000) note: Cj1584c, probable peptide ABC-transport system periplasmic peptide-binding protein,len: 511 aa; similar to e.g. APPA_BACSU oligopeptide-binding protein APPA precursor (543 aa),fasta scores; opt: 700 z-score: 791.8 E(): 0, 30.5% identity in 509 aa overlap. 26.7% identity to HP0298. Contains probable N-terminal signal sequence and Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5; Updated (2006) note: Prosite domain PS00092 N6_MTASE, N-6 Adenine-specific DNA methylases signature identified within CDS. Similar to different transport systems with acceptable identity scores. kept within product function. Functional classification -Transport/binding proteins - Other; peptide ABC transporter periplasmic peptide-binding protein 1514534 905854 Cj1584c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptide ABC transporter periplasmic peptide-binding protein YP_002344953.1 1512999 R 192222 CDS YP_002344954.1 218563174 905855 complement(1514644..1517415) 1 NC_002163.1 Original (2000) note: Cj1585c, probable oxidoreductase, len: 923 aa; similar to e.g. YDIJ_ECOLI (1018 aa), fasta scores; opt: 299 z-score: 326.0 E(): 7.7e-11, 24.0% identity in 668 aa overlap, and GLCD_ECOLI glycolate oxidase subunit GLCD (499 aa), fasta scores; opt: 258 z-score: 285.3 E(): 1.4e-08, 23.4% identity in 483 aa overlap. 49.2% identity to HP1222 (misannotated as D-lactate dehydrogenase). Contains PS00551 Prokaryotic molybdopterin oxidoreductases signature 1, ands 2x PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; Updated (2006) note: Pfam domains PF02913 FAD linked oxidases, C-terminal domain and PF01565 FAD binding domain were identified within CDS. Not specifically characterised with acceptable identity score. Thus, kept within product function. Literature search identified paper giving further support to product function. Functional classification - Misc; PMID:15292134; oxidoreductase 1517415 905855 Cj1585c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 oxidoreductase YP_002344954.1 1514644 R 192222 CDS YP_002344955.1 218563175 905856 1517567..1517989 1 NC_002163.1 Original (2000) note: Cj1586, probable bacterial haemoglobin, len: 140 aa; similar to e.g. BAHG_VITST bacterial hemoglobin (soluble cytochrome O) (146 aa),fasta scores; opt: 417 z-score: 527.0 E(): 4.9e-22, 49.6% identity in 141 aa overlap. No Hp match. Contains Pfam match to entry PF00042 globin; Updated (2006) note: Characterised within Campylobacter jejuni. Cgb protein plays a role in detoxification of NO and related compounds. NssR (Nitrosative stress sensing Regulator - Cj0466) controls the expression of a nitrosative stress-responsive regulon in Campylobacter jejuni which includes ctb (Cj0465c) and cgb (Cj1586). not added to product function. Functional classification - Energy metabolism - Electron transport; PMID:16045618, PMID:15292134, PMID:16339953,PMID:16681372; single domain haemoglobin 1517989 cgb 905856 cgb Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 single domain haemoglobin YP_002344955.1 1517567 D 192222 CDS YP_002344956.1 218563176 905857 complement(1518009..1519640) 1 NC_002163.1 efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding component 1519640 905857 Cj1587c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 multidrug transporter membrane component/ATP-binding component YP_002344956.1 1518009 R 192222 CDS YP_002344957.1 218563177 905858 complement(1519690..1520985) 1 NC_002163.1 Original (2000) note: Cj1588c, probable transmembrane transport protein, len: 431 aa; similar to e.g. YHJE_ECOLI hypothetical metabolite transport protein (440 aa), fasta scores; opt: 682 z-score: 771.4 E(): 0,28.9% identity in 422 aa overlap, and PROP_ECOLI proline/betaine transporter (proline porter II) (500 aa),fasta scores; opt: 655 z-score: 740.4 E(): 0, 30.1% identity in 415 aa overlap. No Hp ortholog. Contains PS00217 Sugar transport proteins signature 2, and Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporters; Updated (2006) note: Pfam domain PF07690 Major Facilitator Superfamily identified within CDS. Also,twelve probable transmembrane helices predicted by TMHMM2.0. Not specifically characterised yet with acceptable identity score. Product function modified based on motif match. kept within product function. Functional classification - Transport/binding proteins -Other; MFS transport protein 1520985 905858 Cj1588c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 MFS transport protein YP_002344957.1 1519690 R 192222 CDS YP_002344958.1 218563178 905859 1521072..1521869 1 NC_002163.1 Original (2000) note: Cj1589, unknown, len: 265 aa; some similarity to TR:O34910 (EMBL:AF027868) Bacillus subtilis YOBT (233 aa), fasta scores; opt: 178 z-score: 211.5 E(): 0.00019, 27.6% identity in 203 aa overlap. No Hp match. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily. Functional classification - Conserved hypothetical proteins; hypothetical protein 1521869 905859 Cj1589 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344958.1 1521072 D 192222 CDS YP_002344959.1 218563179 905860 1521957..1522175 1 NC_002163.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1522175 infA 905860 infA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 translation initiation factor IF-1 YP_002344959.1 1521957 D 192222 CDS YP_002344960.1 218563180 905861 1522347..1522460 1 NC_002163.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 1522460 rpmJ 905861 rpmJ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L36 YP_002344960.1 1522347 D 192222 CDS YP_002344961.1 218563181 905825 1522463..1522828 1 NC_002163.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 1522828 rpsM 905825 rpsM Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S13 YP_002344961.1 1522463 D 192222 CDS YP_002344962.1 218563182 905862 1522838..1523230 1 NC_002163.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 1523230 rpsK 905862 rpsK Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S11 YP_002344962.1 1522838 D 192222 CDS YP_002344963.1 218563183 905863 1523258..1523884 1 NC_002163.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 1523884 rpsD 905863 rpsD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S4 YP_002344963.1 1523258 D 192222 CDS YP_002344964.1 218563184 905865 1523897..1524910 1 NC_002163.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 1524910 rpoA 905865 rpoA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA-directed RNA polymerase subunit alpha YP_002344964.1 1523897 D 192222 CDS YP_002344965.1 218563185 905866 1524914..1525267 1 NC_002163.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 1525267 rplQ 905866 rplQ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L17 YP_002344965.1 1524914 D 192222 CDS YP_002344966.1 218563186 905867 1525440..1526339 1 NC_002163.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 1526339 hisG 905867 hisG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP phosphoribosyltransferase YP_002344966.1 1525440 D 192222 CDS YP_002344967.1 218563187 905868 1526347..1527633 1 NC_002163.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1527633 hisD 905868 hisD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 histidinol dehydrogenase YP_002344967.1 1526347 D 192222 CDS YP_002344968.1 218563188 905869 1527630..1528688 1 NC_002163.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 1528688 hisB 905869 hisB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_002344968.1 1527630 D 192222 CDS YP_002344969.1 218563189 904385 1528685..1529272 1 NC_002163.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1529272 hisH 904385 hisH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 imidazole glycerol phosphate synthase subunit HisH YP_002344969.1 1528685 D 192222 CDS YP_002344970.1 218563190 904505 1529269..1530000 1 NC_002163.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1530000 hisA 904505 hisA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_002344970.1 1529269 D 192222 CDS YP_002344971.1 218563191 905870 1529985..1530941 1 NC_002163.1 Original (2000) note: Cj1602, unknown, len: 318 aa; 35.8% identity to HP0852; Updated (2006) note: Pfam domain PF04373 Protein of unknown function (DUF511) identified within CDS. Conserved added to product function. Functional classification -Conserved hypothetical proteins; PMID:11956101, PMID:15901688; hypothetical protein 1530941 905870 Cj1602 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344971.1 1529985 D 192222 CDS YP_002344972.1 218563192 905871 1530942..1531709 1 NC_002163.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1531709 hisF 905871 hisF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 imidazole glycerol phosphate synthase subunit HisF YP_002344972.1 1530942 D 192222 CDS YP_002344973.1 218563193 905159 1531711..1532334 1 NC_002163.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 1532334 hisI 905159 hisI Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase YP_002344973.1 1531711 D 192222 CDS YP_002344974.1 218563194 905872 complement(1532359..1533519) 1 NC_002163.1 Updated (2006) note: Identity score with Escherichia coli was marginal. kept within product function as sequence alignment was partial; Original (2000) note: Cj1605c, dapD, possible 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase, len: 386 aa; simlar in N-terminus to e.g. TR:O69283 (EMBL:AJ004934) Corynebacterium glutamicum tetrahydrodipicolinate succinylase (EC 2.3.1.117) (230 aa), fasta scores; opt: 587 z-score: 643.6 E(): 1.6e-28, 47.3% identity in 245 aa overlap, and weakly similar to DAPD_ECOLI 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase (EC 2.3.1.117) (274 aa), fasta scores; opt: 190 z-score: 214.3 E(): 0.00013, 27.3% identity in 143 aa overlap. 48.5% identity to HP0626. Functional classification - Amino acid biosynthesis -Aspartate family; 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase 1533519 dapD 905872 dapD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase YP_002344974.1 1532359 R 192222 CDS YP_002344975.1 218563195 905873 complement(1533545..1534651) 1 NC_002163.1 Original (2000) note: Cj1606c, mrp, probable ATP/GTP-binding protein (mrp protein homolog), len: 368 aa; similar to many members of the MRP family e.g. MRP_ECOLI MRP protein (379 aa), fasta scores; opt: 839 z-score: 921.1 E(): 0, 37.1% identity in 340 aa overlap. 50.1% identity to HP0207. Also similar to Cj0063c (31.4% identity in 159 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Pfam domain PF01883 Domain of unknown function DUF59 identified within CDS. Functional classification - Conserved hypothetical proteins; ATP/GTP-binding protein 1534651 mrp 905873 mrp Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP/GTP-binding protein YP_002344975.1 1533545 R 192222 CDS YP_002344976.1 218563196 905874 1534774..1535889 1 NC_002163.1 bifunctional enzyme involved in formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate and 2-C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP from 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; binds divalent cations; bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 1535889 ispDF 905874 ispDF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_002344976.1 1534774 D 192222 CDS YP_002344977.1 218563197 905875 1535886..1536773 1 NC_002163.1 Original (2000) note: Cj1608, possible two-component regulator, len: 295 aa, some similarity to regulatory components of tw-component systems e.g. TR:O87527 (EMBL:AF082668) Streptococcus pyogenes capsule synthesis regulator CSRR (228 aa), fasta scores; opt: 170 z-score: 203.9 E(): 0.00049, 35.0% identity in 123 aa overlap, and BASR_ECOLI transcriptional regulatory protein (222 aa), blastp scores; E = 1.6e-06 29% identity in 113 aa overlap. 33.8% identity to HP1021. Contains helix-turn-helix motif at aa 271-292 (Score 997, +2.58 SD). Also some similarity to Cj1024c (22.0% identity in 341 aa overlap); Updated (2006) note: PMID:15901688; Updated (2006) note: Pfam domain PF00072 Response regulator receiver domain identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet. kept within product function. Literature search identified paper giving further information on product function. Functional classification - Signal transduction; PMID:15901688; two-component regulator 1536773 905875 Cj1608 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 two-component regulator YP_002344977.1 1535886 D 192222 CDS YP_002344978.1 218563198 905876 1536751..1537911 1 NC_002163.1 Original (2000) note: Cj1609, possible sulfate adenylyltransferase, len: 386 aa; similar to e.g. TR:O34764 (EMBL:) BAcillus subtilis sulfate adenylyltransferase (382 aa), fasta scores; opt: 360 z-score: 414.1 E(): 9.6e-16, 23.4% identity in 351 aa overlap, and TR:O66036 (EMBL:U84759) Chromatium vinosum sulfate adenylyltransferase (EC 2.7.7.4) (397 aa), fasta scores; opt: 273 z-score: 315.2 E(): 3.1e-10, 21.8% identity in 357 aa overlap. No Hp match; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. kept within product function. Functional classification -Central intermediary metabolism - Sulphur metabolism; sulfate adenylyltransferase 1537911 905876 Cj1609 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 sulfate adenylyltransferase YP_002344978.1 1536751 D 192222 CDS YP_002344979.1 218563199 905877 1537916..1538416 1 NC_002163.1 Original (2000) note: Cj1610, pgpA, probable phosphatidylglycerophosphatase, len: 166 aa; simlar to e.g. PGPA_ECOLI phosphatidylglycerophosphatase A (EC 3.1.3.27) (172 aa), fasta scores; opt: 238 z-score: 319.5 E(): 1.8e-10, 33.3% identity in 135 aa overlap. 47.1% identity to HP0737; Updated (2006) note: Three probable transmembrane helices predicted by TMHMM2.0. Some characterisation work carried out within Escherichia coli, however, identity score was marginal. Sequence alignment was only partial. kept within product function. Functional classification - Synthesis and modification of macromolecules - Phospholipids; PMID:2846510, PMID:1309518; phosphatidylglycerophosphatase 1538416 pgpA 905877 pgpA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphatidylglycerophosphatase YP_002344979.1 1537916 D 192222 CDS YP_002344980.1 218563200 905878 1538495..1538758 1 NC_002163.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 1538758 rpsT 905878 rpsT Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S20 YP_002344980.1 1538495 D 192222 CDS YP_002344981.1 218563201 905879 1538777..1539844 1 NC_002163.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1539844 prfA 905879 prfA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 peptide chain release factor 1 YP_002344981.1 1538777 D 192222 CDS YP_002344982.1 218563202 905880 complement(1539858..1540613) 1 NC_002163.1 Original (2000) note: Cj1613c, unknown, len: 251 aa; similar to hypothetical proteins e.g. Y854_HAEIN hypothetical protein HI0854 (253 aa), fasta scores; opt: 827 z-score: 991.6 E(): 0, 48.4% identity in 248 aa overlap. 56.1% identity to HP0318; Updated (2006) note: Pfam domain PF01243 Pyridoxamine 5'-phosphate oxidase identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation with acceptable identity score has been carried out yet. kept within product function. Literature search identified paper (PMID:15632442) giving further clues to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Pyridoxine; PMID:15632442, PMID:12686112; pyridoxamine 5'-phosphate oxidase 1540613 905880 Cj1613c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 pyridoxamine 5'-phosphate oxidase YP_002344982.1 1539858 R 192222 CDS YP_002344983.1 218563203 905881 1540807..1542936 1 NC_002163.1 Original (2000) note: Cj1614, chuA, haemin uptake system outer membrane receptor, len: 709 aa; mutants are unable to grow on haemin - see van Vliet et al, J. Bact 180, 5921-5298 (1998). Similar to TR:O85161 (EMBL:AF047484) Vibrio vulnificus heme receptor (712 aa),fasta scores; opt: 270 z-score: 302.6 E(): 1.6e-09, 22.9% identity in 750 aa overlap, and TR:Q56644 (EMBL:L27149) Vibrio cholerae heme receptor (693 aa), fast scores; opt: 242 z-score: 271.3 E(): 8.6e-08, 23.0% identity in 744 aa overlap. 21.6% identity to HP0807. Also similar to Cj0755 (23.6% identity in 770 aa overlap), and Cj0444 (32.1% identity in 190 aa overlap). Contains Pfam match to entry PF00593 TonB_boxC, TonB dependant receptor C-terminal region; Updated (2006) note: Characterisation work within Campylobacter jejuni. not added to product function. Functional classification - Transport/binding proteins - Cations; PMID:9157252, PMID:9765558; haemin uptake system outer membrane receptor 1542936 chuA 905881 chuA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 haemin uptake system outer membrane receptor YP_002344983.1 1540807 D 192222 CDS YP_002344984.1 218563204 905882 1542911..1543897 1 NC_002163.1 Original (2000) note: Cj1615, chuB, probable haemin uptake system permease, len: 328 aa; similar to e.g. FHUB_BACSU ferrichrome transport permease FHUB (384 aa), fasta scores; opt: 505 z-score: 606.7 E(): 1.8e-26, 29.5% identity in 336 aa overlap. 31.2% identity to HP0889. Contains Pfam match to entry PF01032 FecCD_family, FecCD transport family. Predicted function is based on apparent co-transcription with Cj1614 chuA; Updated (2006) note: Nine probable transmembrane helices predicted by TMHMM2.0. Yet to be specifically characterised with acceptable identity score. kept within product function. Functional classification -Transport/binding proteins - Cations; PMID:9765558; hemin uptake system permease 1543897 chuB 905882 chuB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hemin uptake system permease YP_002344984.1 1542911 D 192222 CDS YP_002344985.1 218563205 905883 1543897..1544673 1 NC_002163.1 Original (2000) note: Cj1616, chuC, probable haemin uptake system ATP-binding protein, len: 258 aa; similar to e.g. FEPC_ECOLI ferric enterobactin transport ATP-binding protein (271 aa), fasta scores; opt: 477 z-score: 544.5 E(): 5.2e-23, 32.6% identity in 242 aa overlap. 32.9% identity to HP0888. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran, ABC transporters. Predicted function is based on apparent co-transcription with Cj1614 chuA; Updated (2006) note: Yet to be specifically characterised with acceptable identity score. kept within product function. Functional classification -Transport/binding proteins - Cations; PMID:9765558; hemin uptake system ATP-binding protein 1544673 chuC 905883 chuC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hemin uptake system ATP-binding protein YP_002344985.1 1543897 D 192222 CDS YP_002344986.1 218563206 905884 1544670..1545476 1 NC_002163.1 Original (2000) note: Cj1617, chuD, probable haemin uptake system periplasmic haemin-binding protein, len: 268 aa; similar to e.g. HMUT_YERPE hemin-binding periplasmic protein HMUT precursor (278 aa), fasta scores; opt: 189 z-score: 223.7 E(): 3.9e-05, 23.9% identity in 230 aa overlap. No Hp match. Contains probable N-terminal signal sequence. Predicted function is based on apparent co-transcription with Cj1614 chuA; Updated (2006) note: Pfam domain PF01497 Periplasmic binding protein identified within CDS. Further support given to product function. Yet to be specifically characterised with acceptable identity score. kept within product function. Functional classification -Transport/binding proteins - Cations; PMID:9765558; hemin uptake system periplasmic hemin-binding protein 1545476 chuD 905884 chuD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hemin uptake system periplasmic hemin-binding protein YP_002344986.1 1544670 D 192222 CDS YP_002344987.1 218563207 905885 complement(1545473..1546390) 1 NC_002163.1 Original (2000) note: Cj1618c, unknown, len: 305 aa; weak similarity to hypothetical proteins e.g. TR:Q59026 (EMBL:U67603) Methanococcus jannaschii hypothetical protein MJ1632 (255 aa), fasta scores; opt: 138 z-score: 169.9 E(): 0.038, 25.8% identity in 256 aa overlap (contains predicted iron-sulfur cluster which is conserved in Cj1618c). 34.5% identity to HP0568; Updated (2006) note: Pfam domain PF04055 Radical SAM superfamily identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out yet. kept within product function. Functional classification - Misc; radical SAM domain protein 1546390 905885 Cj1618c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 radical SAM domain protein YP_002344987.1 1545473 R 192222 CDS YP_002344988.1 218563208 905886 1546496..1547755 1 NC_002163.1 Original (2000) note: Cj1619, kgtP, probable alpha-ketoglutarate permease, len: 419 aa; similar to KGTP_ECOLI alpha-ketoglutarate permease (432 aa), fasta scores; opt: 1348 z-score: 1575.2 E(): 0, 49.0% identity in 414 aa overlap. 49.9% identity to HP1091. Contains PS00217 Sugar transport proteins signature 2, and Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporters; Updated (2006) note: PMID:2053984; Updated (2006) note: Twelve probable transmembrane helices predicted by TMHMM2.0. Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Transport/binding proteins - Carbohydrates, organic acids and alcohols; PMID:2053984; alpha-ketoglutarate permease 1547755 kgtP 905886 kgtP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 alpha-ketoglutarate permease YP_002344988.1 1546496 D 192222 CDS YP_002344989.1 218563209 905887 complement(1547741..1548760) 1 NC_002163.1 Original (2000) note: Cj1620c, mutY, probable A/G-specific adenine glycosylase, len: 339 aa; similar to e.g. MUTY_ECOLI A/G-specific adenine glycosylase (EC 3.2.2.-) (350 aa), blastp scores; E= 1.0e-41, 39% identity in 271 aa overlap. 47.6% identity to HP0142. Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III; Updated (2006) note: Pfam domain PF00730 HhH-GPD superfamily base excision DNA repair and PF00633 Helix-hairpin-helix motif were both identified within CDS. Further support given to product function. Characterisation work has been carried out within Escherichia coli with acceptable identity score. not added to product function. Functional classification -DNA replication, restriction/modification, recombination and repair; PMID:2197596, PMID:9846876, PMID:15456766; A/G-specific adenine glycosylase 1548760 mutY 905887 mutY Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 A/G-specific adenine glycosylase YP_002344989.1 1547741 R 192222 CDS YP_002344990.1 218563210 905888 1548833..1549585 1 NC_002163.1 Original (2000) note: Cj1621, possible periplasmic protein, len: 250 aa; no Hp match. Contains probable N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1549585 905888 Cj1621 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344990.1 1548833 D 192222 CDS YP_002344991.1 218563211 905894 1550235..1551245 1 NC_002163.1 Original (2000) note: Cj1622, ribD, probable riboflavin-specific deaminase, len: 336 aa; similar to e.g. RIBD_ACTPL riboflavin-specific deaminase (EC 3.5.4.-) (410 aa), fasta scores; opt: 320 z-score: 381.1 E(): 6.6e-14, 35.7% identity in 235 aa overlap, and RIBD_ECOLI riboflavin-specific deaminase (EC 3.5.4.-). (367 aa), opt: 249 z-score: 298.4 E(): 2.7e-09, 28.4% identity in 282 aa overlap. 37.9% identity to ; HP1505. Contains Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminases zinc-binding region; Updated (2006) note: Characterisation has been carried out within Helicobacter pylori and Escherichia coli and identity scores were acceptable. Product function modified to more specific function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carriers - Riboflavin; PMID:11024263, PMID:9068650; riboflavin-specific deaminase/reductase 1551245 ribD 905894 ribD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 riboflavin-specific deaminase/reductase YP_002344991.1 1550235 D 192222 CDS YP_002344992.1 218563212 905895 1551226..1551747 1 NC_002163.1 Original (2000) note: Cj1623, probable membrane protein, len: 173 aa; no Hp match; Updated (2006) note: Two probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins; hypothetical protein 1551747 905895 Cj1623 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344992.1 1551226 D 192222 CDS YP_002344993.1 218563213 905896 complement(1551755..1553119) 1 NC_002163.1 Original (2000) note: Cj1624c, sdaA, probable L-serine dehydratase, len: 454 aa; similar to many e.g. SDHL_ECOLI L-serine dehydratase 1 (EC 4.2.1.13) (454 aa),fasta scores; opt: 1316 z-score: 1553.3 E(): 0, 46.0% identity in 465 aa overlap. 53.4% identity to HP0132; Updated (2006) note: Pfam domains PF03313 Serine dehydratase alpha chain and PF03315 Serine dehydratase beta chain were identified within CDS. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Degradation - Amino acids; PMID:8436113, PMID:14688104; L-serine dehydratase 1553119 sdaA 905896 sdaA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 L-serine dehydratase YP_002344993.1 1551755 R 192222 CDS YP_002344994.1 218563214 905897 complement(1553134..1554384) 1 NC_002163.1 Original (2000) note: Cj1625c, sdaC, probable serine transporter, len: 416 aa; similar to e.g. SDAC_ECOLI serine transporter (429 aa), fasta scores; opt: 1392 z-score: 1574.7 E(): 0, 50.1% identity in 417 aa overlap, and TDCC_ECOLI threonine/serine transporter (443 aa), fasta scores; opt: 848 z-score: 961.6 E(): 0, 43.8% identity in 432 aa overlap. 42.0% identity to HP0133; Updated (2006) note: Prosite domains PS50286 AROMATIC_AA_PERM_2, Amino acid/polyamine transporter II and PS50285 AMINO_ACID_PERMEASE_2, Amino acid/polyamine transporter I were identified within CDS. Further support given to product function. Eleven probable transmembrane helices predicted by TMHMM2.0. Characterised within Escherichia coli with acceptable identity scores. Product function updated. not added to product function. Functional classification - Transport/binding proteins -Amino acids and amines; PMID:8026499, PMID:15743941, PMID:14688104; amino acid transporter 1554384 sdaC 905897 sdaC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 amino acid transporter YP_002344994.1 1553134 R 192222 CDS YP_002344995.1 218563215 905898 complement(1554644..1555060) 1 NC_002163.1 Original (2000) note: Cj1626c, probable periplasmic protein, len: 138 aa; no Hp match. Also similar to Cj1004 (38.6% identity in 140 aa overlap), and in N-terminus to Cj1722c (53.1% identity in 32 aa overlap); Updated (2006) note: Literature search identified paper giving further clues to product function. Functional classification - Miscellaneous periplasmic proteins; PMID:15554967; periplasmic protein 1555060 905898 Cj1626c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002344995.1 1554644 R 192222 CDS YP_002344996.1 218563216 905899 complement(1555124..1555867) 1 NC_002163.1 Original (2000) note: Cj1627c, unknown, len: 247 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown; hypothetical protein 1555867 905899 Cj1627c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002344996.1 1555124 R 192222 CDS YP_002344997.1 218563217 905901 1556025..1556450 1 NC_002163.1 Original (2000) note: Cj1628, exbB2, probable exbB/tolQ family transport protein, len: 141 aa; similar to many e.g. EXBB_HAEDU biopolymer transport EXBB protein (150 aa), fasta scores; opt: 426 z-score: 531.7 E(): 2.7e-22, 51.2% identity in 129 aa overlap. 54.4% identity to HP1339. Also similar to Cj0179 exbB (31.3% identity in 150 aa overlap), and Cj0109 exbB2 (44.4% identity in 81 aa overlap); Updated (2006) note: Pfam domain PF01618 MotA/TolQ/ExbB proton channel family identified within CDS. Further support given to product function. Three probable transmembrane helices predicted by TMHMM2.0. No specific characterisation has been carried out yet, so kept within product function. Functional classification - Transport/binding proteins - Other; PMID:9781885; exbB/tolQ family transport protein 1556450 exbB2 905901 exbB2 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 exbB/tolQ family transport protein YP_002344997.1 1556025 D 192222 CDS YP_002344998.1 218563218 905902 1556443..1556832 1 NC_002163.1 Original (2000) note: Cj1629, exbD2, probable exbD/tolR family transport protein, len: 129 aa; similar to many e.g. EXBD_HAEDU biopolymer transport EXBD protein (129 aa), fasta scores; opt: 337 z-score: 414.6 E(): 9e-16, 44.8% identity in 125 aa overlap. 49.6% identity to HP1340. Also similar to Cj0180 exbD (31.1% identity in 122 aa overlap) and Cj0110 exbD2 (26.4% identity in 121 aa overlap); Updated (2006) note: Pfam domain PF02472 Biopolymer transport protein ExbD/TolR identified within CDS. Further support given to product function. One probable transmembrane helices predicted by TMHMM2.0. No specific characterisation with acceptable identity score carried out yet, so kept within product function. Functional classification - Transport/binding proteins -Other; PMID:9781885; exbD/tolR family transport protein 1556832 exbD2 905902 exbD2 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 exbD/tolR family transport protein YP_002344998.1 1556443 D 192222 CDS YP_002344999.1 218563219 905903 1556829..1557512 1 NC_002163.1 Original (2000) note: Cj1630, tonB2, probable tonB transport protein, len: 227 aa; similar to many e.g. TONB_CAMCO TONB protein (232 aa), fasta scores; opt: 412 z-score: 428.1 E(): 1.6e-16, 41.9% identity in 236 aa overlap. 25.9% identity to HP0582. Also similar to Cj0753c tonB (41.7% identity in 230 aa overlap); Updated (2006) note: Pfam domain PF03544 Gram-negative bacterial tonB protein identified within CDS. Further support given to product function. Also, one probable transmembrane helix predicted by TMHMM2.0. Some characterisation work carried out within Campylobacter coli with acceptable identity score. Characterisation work also carried out within Vibrio cholerae, however, identity score was unnacceptable. kept within product function. Functional classification - Transport/binding proteins - Other; PMID:9190817, PMID:10689178, PMID:15557661; TonB transport protein 1557512 tonB2 905903 tonB2 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 TonB transport protein YP_002344999.1 1556829 D 192222 CDS YP_002345000.1 218563220 905904 complement(1557525..1558394) 1 NC_002163.1 Original (2000) note: Cj1631c, unknown, len: 289 aa; no Hp match. Contains PS00018 EF-hand calcium-binding domain. Functional classification - Unknown; hypothetical protein 1558394 905904 Cj1631c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002345000.1 1557525 R 192222 CDS YP_002345001.1 218563221 905905 complement(1558398..1558559) 1 NC_002163.1 Original (2000) note: Cj1632c, possible periplasmic protein, len: 53 aa; no Hp match. Contains possible N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1558559 905905 Cj1632c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002345001.1 1558398 R 192222 CDS YP_002345002.1 218563222 905906 1558654..1559637 1 NC_002163.1 Original (2000) note: Cj1633, unknown, len: 327 aa; similar to hypothetical proteins e.g. TR:O67046 (EMBL:AE000713) Aquifex aeolicus AQ_898 (251 aa), fasta scores; opt: 544 z-score: 648.2 E(): 8.8e-29, 50.2% identity in 221 aa overlap. 44.7% identity to HP0013. Contains HP0013; Updated (2006) note: Pfam domain PF01902 ATP-binding region identified within CDS. Product function modified to more specific family member based on motif match. kept within product function. Functional classification - Conserved hypothetical proteins; ATP-binding protein 1559637 905906 Cj1633 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ATP-binding protein YP_002345002.1 1558654 D 192222 CDS YP_002345003.1 218563223 905907 complement(1559723..1560811) 1 NC_002163.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1560811 aroC 905907 aroC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 chorismate synthase YP_002345003.1 1559723 R 192222 CDS YP_002345004.1 218563224 905908 complement(1560811..1561485) 1 NC_002163.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 1561485 rnc 905908 rnc Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribonuclease III YP_002345004.1 1560811 R 192222 CDS YP_002345005.1 218563225 905909 complement(1561472..1561912) 1 NC_002163.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 1561912 rnhA 905909 rnhA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribonuclease H YP_002345005.1 1561472 R 192222 CDS YP_002345006.1 218563226 905910 complement(1561899..1562885) 1 NC_002163.1 Original (2000) note: Cj1637c, probable periplasmic protein, len: 328 aa; 26.1% identity to HP0660. Contains possible N-terminal signal sequence; Updated (2006) note: Pfam domain PF07719 Tetratricopeptide repeat identified within CDS. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 1562885 905910 Cj1637c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002345006.1 1561899 R 192222 CDS YP_002345007.1 218563227 905911 1562955..1564772 1 NC_002163.1 synthesizes RNA primers at the replication forks; DNA primase 1564772 dnaG 905911 dnaG Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA primase YP_002345007.1 1562955 D 192222 CDS YP_002345008.1 218563228 905912 1564854..1565126 1 NC_002163.1 Original (2000) note: Cj1639, unknown, len: 90 aa; similar to members of the NIFU family of hypothetical poteins e.g. NIU1_RHOCA NIFU protein 1 (135 aa), fasta scores; opt: 158 z-score: 219.3 E(): 6.8e-05 36.5% identity in 63 aa overlap. Identical to TR:O69292 (EMBL:Y16882) C. jejuni NIFU-like protein. 52.2% identity to HP1492. Contains Pfam match to entry PF01106 NifU-like,NifU-like domain. Also similar to N-terminus of Cj0239c (38.2% identity in 76 aa overlap). Functional classification - Conserved hypothetical proteins; NifU protein 1565126 905912 Cj1639 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 NifU protein YP_002345008.1 1564854 D 192222 CDS YP_002345009.1 218563229 905913 1565113..1565664 1 NC_002163.1 Original (2000) note: Cj1640, unknown, len: 183 aa; 27.7% identity to HP1493. Functional classification -Conserved hypothetical proteins; hypothetical protein 1565664 905913 Cj1640 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002345009.1 1565113 D 192222 CDS YP_002345010.1 218563230 905914 1565648..1566931 1 NC_002163.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1566931 murE 905914 murE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_002345010.1 1565648 D 192222 CDS YP_002345011.1 218563231 905915 1566935..1567246 1 NC_002163.1 Original (2000) note: Cj1642, unknown, len: 309 aa; similar to hypothetical proteins e.g. TR:O34247 (EMBL:AJ003049) Wolinella succinogenes ORF102 (102 aa),fasta scores; opt: 351 z-score: 446.1 E(): 1.6e-17, 62.5% identity in 96 aa overlap, and YBAB_ECOLI (109 aa), fast scores; opt: 182 z-score: 240.6 E(): 4.4e-06, 36.7% identity in 98 aa overlap. 45.4% identity to HP0035; Updated (2006) note: Pfam domain PF02575 Uncharacterised BCR, YbaB family COG0718 identified within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 1567246 905915 Cj1642 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002345011.1 1566935 D 192222 CDS YP_002345012.1 218563232 905916 1567243..1568337 1 NC_002163.1 Original (2000) note: Cj1643, probable periplasmic protein, len: 364 aa; similar to hypothetical proteins e.g. TR:O34248 (EMBL:AJ003049) Wolinella succinogenes ORF341 protein (341 aa), fasta scores; opt: 238 z-score: 283.8 E(): 1.7e-08, 23.6% identity in 314 aa overlap. 25.5% identity to HP0036. Contains probable N-terminal signal sequence, and Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF); Updated (2006) note: Paper identified linking protein to glycoprotein. Functional classification -Miscellaneous periplasmic proteins; PMID:12186869; periplasmic protein 1568337 905916 Cj1643 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002345012.1 1567243 D 192222 CDS YP_002345013.1 218563233 905917 1568334..1569179 1 NC_002163.1 Original (2000) note: Cj1644, ispA, probable geranyltranstransferase, len: 281 aa; similar to many e.g. ISPA_ECOLI geranyltranstransferase (EC 2.5.1.10) (FARN (299 aa), fast scores; opt: 520 z-score: 633.4 E(): 5.8e-28, 37.5% identity in 275 aa overlap. 48.0% identity to HP0929. Alos similar to Cj0541 (27.6% identity in 268 aa overlap). Contains PS00723 and PS00444 Polyprenyl synthetases signatures 1 and 2, and Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification -Biosynthesis of cofactors, prosthetic groups and carriers - Menaquinone and ubiquinine; PMID:2089044; geranyltranstransferase 1569179 ispA 905917 ispA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 geranyltranstransferase YP_002345013.1 1568334 D 192222 CDS YP_002345014.1 218563234 905918 1569190..1571088 1 NC_002163.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1571088 tkt 905918 tkt Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transketolase YP_002345014.1 1569190 D 192222 CDS YP_002345015.1 218563235 905919 1571090..1572199 1 NC_002163.1 Original (2000) note: Cj1646, iamB, possible ABC transport system permease, len: 369 aa; 91.6% identity to TR:O68254 (EMBL:AF023133) C. jejuni iamB gene fragment (133 aa). Similar to hypothetical proteins e.g. YRBE_ECOLI (260 aa), fast scores; opt: 363 z-score: 423.9 E(): 2.7e-16, 28.1% identity in 256 aa overlap, and to TR:AAD17958 (EMBL:AF106002) Pseudomonas putida toluene tolerance protein TTG2B (265 aa), fast scores; opt: 381 z-score: 444.3 E(): 2e-17, 30.0% identity in 203 aa overlap. 41.1% identity to HP1466; Updated (2006) note: Pfam domain PF02405 Domain of unknown function DUF140 identified within CDS. Six probable transmembrane helices predicted by TMHMM2.0. Specific characterisation with acceptable identity score has not been carried out yet. kept within product function. Some work carried out within Campylobacter spp. Functional classification - Transport/binding proteins -Other; PMID:11283056, PMID:12694614; ABC transporter permease 1572199 iamB 905919 iamB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter permease YP_002345015.1 1571090 D 192222 CDS YP_002345016.1 218563236 905920 1572200..1572922 1 NC_002163.1 Original (2000) note: Cj1647, iamA, probable ABC transport system ATP-binding protein, len: 240 aa; 89.5% identity to TR:O68255(EMBL:AF023133) C. jejuni iamA ABC-transporter. Similar to hypothetical proteins e.g. YRBF_ECOLI HYPOTHETICAL ABC transporter ATP-binding protein (269 aa), fasta scores; opt: 453 z-score: 533.0 E(): 2.3e-22, 31.8% identity in 239 aa overlap, and to TR:AAD17957 (EMBL:AF106002) Pseudomonas putida toluene tolerance protein TTG2A (269 aa), fasta scores; opt: 491 z-score: 576.9 E(): 8.2e-25, 34.5% identity in 238 aa overlap. 40.5% identity to HP1465. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and fam match to entry PF00005 ABC_tran, ABC transporters; Updated (2006) note: Specific characterisation with acceptable identity score has not been carried out yet. Thus, kept within product function. Some work carried out within Campylobacter spp. Functional classification - Transport/binding proteins - Other; PMID:11283056, PMID:16300911; ABC transporter ATP-binding protein 1572922 iamA 905920 iamA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter ATP-binding protein YP_002345016.1 1572200 D 192222 CDS YP_002345017.1 218563237 905921 1572925..1573815 1 NC_002163.1 Original (2000) note: Cj1648, possible ABC transport system periplasmic substrate-binding protein,len: 296 aa; similar to hypothetical proteins e.g. TR:O67491 (EMBL:AE000744) Aquifex aeolicus AQ_1533 (300 aa), fasta scores; opt: 362 z-score: 406.8 E(): 2.4e-15,29.7% identity in 303 aa overlap, and, weakly, to TR:AAD17959 (EMBL:AF106002) Pseudomonas putida toluene tolerance protein TTG2C (161 aa), fasta scores; opt: 161 z-score: 190.8 E(): 0.0026, 28.7% identity in 122 aa overlap. 24.0% identity to HP1464. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF02470 mce related protein identified within CDS. Specific characterisation with acceptable identity score has not been carried out yet. kept within product function. Functional classification - Transport/binding proteins - Other; ABC transporter substrate-binding protein 1573815 905921 Cj1648 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter substrate-binding protein YP_002345017.1 1572925 D 192222 CDS YP_002345018.1 218563238 905922 1573815..1574414 1 NC_002163.1 Original (2000) note: Cj1649, probable lipoprotein,len: 199 aa; some similarity to YFXK_BRAJA hypothetical protein in (fragment) (180 aa), fast scores; opt: 184 z-score: 235.4 E(): 8.6e-06, 24.5% identity in 143 aa overlap. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. No Hp match. Functional classification - Membranes, lipoproteins and porins; lipoprotein 1574414 905922 Cj1649 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002345018.1 1573815 D 192222 CDS YP_002345019.1 218563239 905923 1574470..1574970 1 NC_002163.1 Original (2000) note: Cj1650, unknown, len: 166 aa; 30.7% identity to HP1076. Functional classification -Conserved hypothetical proteins; hypothetical protein 1574970 905923 Cj1650 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002345019.1 1574470 D 192222 CDS YP_002345020.1 218563240 905924 complement(1575339..1576097) 1 NC_002163.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 1576097 map 905924 map Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 methionine aminopeptidase YP_002345020.1 1575339 R 192222 CDS YP_002345021.1 218563241 905925 complement(1576099..1576851) 1 NC_002163.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1576851 murI 905925 murI Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 glutamate racemase YP_002345021.1 1576099 R 192222 CDS YP_002345022.1 218563242 905926 complement(1576853..1577311) 1 NC_002163.1 Original (2000) note: Cj1653c, probable lipoprotein, len: 152 aa; similar to hypothetical proteins e.g. NLPC_ECOLI probable lipoprotein NLPC precursor (154 aa), fasta scores; opt: 381 z-score: 485.2 E(): 1e-19,40.3% identity in 154 aa overlap, and SPR_ECOLI lipoprotein SPR precursor (188 aa), fasta scores; opt: 355 z-score: 451.8 E(): 7.6e-18, 44.7% identity in 123 aa overlap. No Hp match. Contains probable N-terminal signal sequence with appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site, and Pfam match to entry PF00877 NLPC_P60, NLP/P60 family. Functional classification - Membranes, lipoproteins and porins; lipoprotein 1577311 905926 Cj1653c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002345022.1 1576853 R 192222 CDS YP_002345023.1 218563243 905927 complement(1577320..1578489) 1 NC_002163.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 1578489 nhaA 905927 nhaA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 pH-dependent sodium/proton antiporter YP_002345023.1 1577320 R 192222 CDS YP_002345024.1 218563244 905928 complement(1578486..1579634) 1 NC_002163.1 Original (2000) note: Cj1655c, nhaA1, probable Na(+)/H(+) antiporter, len: 382 aa; similar to e.g. NHAA_ECOLI Na(+)/H(+) antiporter 1 (388 aa), fasta scores; opt: 1165 z-score: 1343.6 E(): 0, 47.3% identity in 383 aa overlap. 41.0% identity to HP1552. Also similar to Cj1654c nhaA2 (56.3% identity in 378 aa overlap); Updated (2006) note: Pfam domain PF06965 Na+/H+ antiporter identified within CDS. Further support given to product function. Also, ten probable transmembrane helices predicted by TMHMM2.0. Characterised within Escherichia coli with acceptable identity score. not added to product function. Functional classification - Transport/binding proteins - Cations; PMID:1645730, PMID:1657980, PMID:9507001; Na(+)/H(+) antiporter 1579634 nhaA1 905928 nhaA1 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Na(+)/H(+) antiporter YP_002345024.1 1578486 R 192222 CDS YP_002345025.1 218563245 905929 complement(1579777..1579959) 1 NC_002163.1 Original (2000) note: Cj1656c, unknown, len: 180 aa; no Hp match. Functional classification - Unknown; hypothetical protein 1579959 905929 Cj1656c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002345025.1 1579777 R 192222 CDS YP_002345026.1 218563246 905930 1580836..1582926 1 NC_002163.1 Original (2000) note: Cj1658, probable integral membrane protein, len: 696 aa; similar to TR:CAA21360 (EMBL:AL031866) Yersinia pestis ORF37 upstream of p19 homolog in 102 kbases unstable region (639 aa), fasta scores; opt: 1055 z-score: 1112.1 E(): 0, 31.6% identity in 706 aa overlap. Contains possible N-terminal signal sequence, followed by non-membrane domain with three coiled-coil regions to aa 440. C-terminal domain contains six possible membrane spanning sequences, and is similar to hypothetical membrane proteins e.g. YWBL_BACSU (481 aa), fasta scores; opt: 439 z-score: 466.4 E(): 1.2e-18,26.5% identity in 449 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03239 Iron permease FTR1 family identified within CDS. Also, seven probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member based on motif match. No specific characterisation has been carried out yet, so kept within product function. Literature search identified paper giving further clues to product function. Functional classification -Transport/binding proteins - Cations; PMID:15632442; iron permease 1582926 905930 Cj1658 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 iron permease YP_002345026.1 1580836 D 192222 CDS YP_002345027.1 218563247 905931 1582923..1583462 1 NC_002163.1 Original (2000) note: Cj1659, p19, periplasmic protein, len: 179 aa; identical to TR:O07089 (EMBL:Y13641) C. jejuni 19 kDa periplamic protein (fragment) (152 aa),and similar to TR:CAA21359 (EMBL:AL031866) Yersinia pestis ORF36 in 102 kbases unstable region (175 aa), fasta scores; opt: 677 z-score: 805.8 E(): 0, 57.9% identity in 178 aa overlap, and TA34_TREPA 34 kD membrane antigen precursor (pathogen-specific membrane antigen) (204 aa),fasta scores; opt: 353 z-score: 425.6 E(): 2.2e-16, 35.8% identity in 159 aa overlap. No Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Characterised within Campylobacter jejuni, so not added to product function. Paper identified linking protein to glycoprotein. Functional classification - Miscellaneous periplasmic proteins; PMID:12186869, PMID:9766213; periplasmic protein p19 1583462 p19 905931 p19 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein p19 YP_002345027.1 1582923 D 192222 CDS YP_002345028.1 218563248 905932 1583545..1584948 1 NC_002163.1 Original (2000) note: Cj1660, probable integral membrane protein, len: 467 aa; 97.3% identity to TR:O07090 (EMBL:Y13641) C. jejuni hypothetical protein (fragment) (73 aa), and similar to TR:CAA21358 (EMBL:AL031866) Yersinia pestis ORF35 in 102 kbases unstable region (469 aa), fasta scores; opt: 687 z-score: 761.3 E(): 0, 27.5% identity in 465 aa overlap. No Hp match; Updated (2006) note: Eight probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Pfam domain PF04945 YHS domain identified within CDS. No specific characterisation with acceptable identity score has been carried out yet, so kept within product function. Literature search identified paper giving further clues to product function. Functional classification - Membranes, lipoproteins and porins; PMID:15632442; integral membrane protein 1584948 905932 Cj1660 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002345028.1 1583545 D 192222 CDS YP_002345029.1 218563249 905933 1584935..1586227 1 NC_002163.1 Original (2000) note: Cj1661, possible ABC transport system permease, len: 430 aa; similar to hypothetical membrane proteins e.g. TR:CAA21357 (EMBL:AL031866) Yersinia pestis ORF34 in 102 kbases unstable region (430 aa), fasta scores; opt: 929 z-score: 1043.7 E(): 0, 36.1% identity in 435 aa overlap, and to the membrane domain of hypothetical ACB-transporters e.g. YBJZ_ECOLI hypothetical ABC transporter ATP-binding protein (648 aa), fasta scores; opt: 189 z-score: 214.0 E(): 0.00014, 22.0% identity in 241 aa overlap. No Hp match. Also similar to Cj1662 (28.1% identity in 437 aa overlap); Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. Pfam domain PF02687 Predicted permease identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score has been carried out yet,so kept within product function. Functional classification - Transport/binding proteins - Other; ABC transporter permease 1586227 905933 Cj1661 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter permease YP_002345029.1 1584935 D 192222 CDS YP_002345030.1 218563250 905934 1586217..1587335 1 NC_002163.1 Original (2000) note: Cj1662, probable integral membrane protein, len: 372 aa; similar to hypothetical membrane proteins e.g. TR:CAA21356 (EMBL:AL031866) Yersinia pestis ORF33 in 102 kbases unstable region (387 aa), fasta scores; opt: 637 z-score: 710.8 E(): 2.9e-32,32.5% identity in 375 aa overlap. No Hp match. Also similar to Cj1661 (28.1% identity in 437 aa overlap). Possibly a permease for an ABC transport system; ABC-binding protein is downstream; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. Pfam domain PF02687 Predicted permease identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score has been carried out yet,so kept within product function. Functional classification - Transport/binding proteins - Other; integral membrane protein 1587335 905934 Cj1662 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 integral membrane protein YP_002345030.1 1586217 D 192222 CDS YP_002345031.1 218563251 905935 1587332..1587985 1 NC_002163.1 Original (2000) note: Cj1663, probable ABC transport system ATP-binding protein, len: 217 aa; similar to many e.g. TR:CAA21355(EMBL:AL031866) Yersinia pestis ORF32 in 102 kbases unstable region (237 aa), fasta scores; opt: 859 z-score: 985.9 E(): 0, 60.8% identity in 209 aa overlap, and GLNQ_ECOLI glutamine transport ATP-binding protein (240 aa), fasta scores; opt: 555 z-score: 641.1 E(): 2.2e-28, 43.5% identity in 214 aa overlap. No Hp ortholog. Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran, ABC transporters; Updated (2006) note: kept within product function as similar to more than one transport system. Functional classification - Transport/binding proteins -Other; ABC transporter ATP-binding protein 1587985 905935 Cj1663 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ABC transporter ATP-binding protein YP_002345031.1 1587332 D 192222 CDS YP_002345032.1 218563252 905936 1587982..1588470 1 NC_002163.1 Original (2000) note: Cj1664, possible periplasmic thiredoxin, len: 162 aa; similar to e.g. TR:CAA21354 (EMBL:AL031866) Yersinia pestis ORF31 in 102 kbases unstable region (165 aa), fast scores; opt: 225 z-score: 278.4 E(): 3.5e-08, 33.3% identity in 141 aa overlap, and weakly to RESA_BACSU RESA protein (contains thiredoxin domain) (181 aa), fasta scores; opt: 124 z-score: 159.5 E(): 0.15, 25.0% identity in 112 aa overlap. No Hp match. Contains PS00194 Thioredoxin family active site and probable N-terminal signal sequence; Updated (2006) note: Specific characterisation with acceptable identity score has not been carried out yet. kept within product function. Literature search identified paper giving further clues to product function (PMID:15632442). Functional classification - Energy metabolism - Respiration - Electron transport; PMID:15322369, PMID:15632442; periplasmic thiredoxin 1588470 905936 Cj1664 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic thiredoxin YP_002345032.1 1587982 D 192222 CDS YP_002345033.1 218563253 905937 1588431..1588934 1 NC_002163.1 Original (2000) note: Cj1665, possible lipoprotein thiredoxin, len: 167 aa; similar to TR:O33920 (EMBL:U75949) Salmonella typhimurium suppressor for copper-sensitivity D (168 aa), fasta scores; opt: 121 z-score: 163.1 E(): 0.093, 27.5% identity in 153 aa overlap, and weakly to many thiredoxins, e.g. THIO_BUCAP thioredoxin (108 aa), fasta scores; opt: 108 z-score: 149.9 E(): 0.5, 28.6% identity in 112 aa overlap. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. No Hp match; Updated (2006) note: Specific characterisation with acceptable identity score has not been carried out yet. kept within product function. Literature search identified paper giving further clues to product function (PMID:15632442). Functional classification - Energy metabolism - Respiration - Electron transport; PMID:15632442; lipoprotein thiredoxin 1588934 905937 Cj1665 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein thiredoxin YP_002345033.1 1588431 D 192222 CDS YP_002345034.1 218563254 905938 complement(1588944..1589381) 1 NC_002163.1 Original (2000) note: Cj1666c, probable periplasmic protein, len: 145 aa; similar to TR:AAD11752 (EMBL:AF067954) Salmonella typhimurium ORF105 in silver resistance cluster (105 aa), fasta scores; opt: 244 z-score: 293.2 E(): 5.2e-09, 39.2% identity in 102 aa overlap, and TR:O67205 (EMBL:AE000724) Aquifex aeolicus AQ_1129 (122 aa), fats scores; opt: 231 z-score: 277.7 E(): 3.8e-08, 33.3% identity in 117 aa overlap. No Hp match. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain PF04214 Protein of unknown function, DUF identified within CDS. Functional classification - Miscellaneous periplasmic proteins; periplasmic protein 1589381 905938 Cj1666c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002345034.1 1588944 R 192222 CDS YP_002345035.1 218563255 905939 complement(1589462..1589614) 1 NC_002163.1 Original (2000) note: Cj1667c, repA protein homolog, len: 50 aa; highly similar to TR:Q46016 (EMBL:X82080) Campylobacter coli plasmid PCCT2 repA protein (26 aa), fast scores; opt: 93 z-score: 179.3 E(): 0.011, 57.7% identity in 26 aa overlap. No Hp match. This gene sequence is < 19% G+C and has an atypical positional base preference. Functional classification - Plasmid related functions; RepA protein 1589614 905939 Cj1667c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 RepA protein YP_002345035.1 1589462 R 192222 CDS YP_002345036.1 218563256 905940 complement(1589680..1590096) 1 NC_002163.1 Original (2000) note: Cj1668c, probable periplasmic protein, len: 138 aa; no Hp match. Contains probable N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1590096 905940 Cj1668c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002345036.1 1589680 R 192222 CDS YP_002345037.1 218563257 905944 complement(1590752..1591600) 1 NC_002163.1 catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA; DNA ligase 1591600 905944 Cj1669c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA ligase YP_002345037.1 1590752 R 192222 CDS YP_002345038.1 218563258 905945 complement(1591600..1592262) 1 NC_002163.1 Original (2000) note: Cj1670c, probable periplasmic protein, len: 220 aa; 27.3% identity to HP0156. Contains probable N-terminal signal sequence; Updated (2006) note: Characterisation paper within Campylobacter jejuni identified new gene name. Papers identified linking protein to glycoprotein (PMID:12186869). Functional classification - Miscellaneous periplasmic proteins; PMID:12186869, PMID:11985725; periplasmic protein 1592262 cgpA 905945 cgpA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002345038.1 1591600 R 192222 CDS YP_002345039.1 218563259 905946 complement(1592252..1592455) 1 NC_002163.1 Original (2000) note: Cj1671c, unknown, len: 67 aa; 38.7% identity to HP0155; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Conserved hypothetical proteins; hypothetical protein 1592455 905946 Cj1671c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002345039.1 1592252 R 192222 CDS YP_002345040.1 218563260 905947 complement(1592521..1593765) 1 NC_002163.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1593765 eno 905947 eno Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 phosphopyruvate hydratase YP_002345040.1 1592521 R 192222 CDS YP_002345041.1 218563261 905948 complement(1593765..1594796) 1 NC_002163.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1594796 recA 905948 recA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 recombinase A YP_002345041.1 1593765 R 192222 CDS YP_002345042.1 218563262 905949 1594902..1595762 1 NC_002163.1 Original (2000) note: Cj1674, unknown, len: 286 aa; similar to hypothetical proteins e.g. TR:AE000683 (EMBL:AE000683) (279 aa), fasta scores; opt: 489 z-score: 599.3 E(): 4.7e-26, 35.4% identity in 260 aa overlap. 58.7% identity to HP0152; Updated (2006) note: Pfam domain PF02642 Uncharacterized ACR, COG2107 identified within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins; hypothetical protein 1595762 905949 Cj1674 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002345042.1 1594902 D 192222 CDS YP_002345043.1 218563263 905950 1595774..1596043 1 NC_002163.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 1596043 fliQ 905950 fliQ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar biosynthesis protein FliQ YP_002345043.1 1595774 D 192222 CDS YP_002345044.1 218563264 905951 1596040..1596816 1 NC_002163.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 1596816 murB 905951 murB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 UDP-N-acetylenolpyruvoylglucosamine reductase YP_002345044.1 1596040 D 192222 CDS YP_002345045.1 218563265 905952 join(1597008..1597589,1597592..1600372) 1 NC_002163.1 Original (2000) note: Cj1678, possible lipoprotein,len: 928 aa; no Hp match. Contains a poly-T tract at aa 1 which, if variable, would allow translation from Cj1677 (which contains a signal sequence and lipid attachment site). Otherwise translation could start at aa 46. Highly similar to Cj0629 (90.7% identity in 901 aa overlap). Cj0629 has a non-variable poly-T tract in an quivalent position, which could allow translation from Cj0628 (similar to Cj1677); Original (2000) note: Cj1677, probable lipoprotein,len: 216 aa; no Hp match. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. There is a poly-T tract at the C-terminus (aa 194) which, if variable, would allow translation into the downstream ORF Cj1678. Similar to Cj0628 which does have a variable poly-T tract at the smae position which could allow translation into Cj0629 (highly similar to Cj1678); Updated (2006) note: Coding sequences have been merged to reflect the complete amino acid sequence for this gene regardless of phase. Previous annotation gave Cj1677 and Cj1678 as seperate CDSs. Merging of these CDSs has lead to loss of the downstream CDS. Functional classification - Membranes, lipoproteins and porins; lipoprotein 1600372 905952 Cj1677 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 lipoprotein YP_002345045.1 1597008 D 192222 CDS YP_002345046.1 218563266 905954 1600574..1602328 1 NC_002163.1 Original (2000) note: Cj1679, unknown, len: 584 aa; no Hp match; Updated (2006) note: Pfam domain x2 PF07719 Tetratricopeptide repeat identified within CDS. Functional classification - Unknown; hypothetical protein 1602328 905954 Cj1679 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002345046.1 1600574 D 192222 CDS YP_002345047.1 218563267 905955 complement(1602332..1603099) 1 NC_002163.1 Original (2000) note: Cj1680c, probable periplasmic protein, len: 255 aa; no Hp match. Contains probable N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1603099 905955 Cj1680c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002345047.1 1602332 R 192222 CDS YP_002345048.1 218563268 905956 complement(1603139..1603903) 1 NC_002163.1 Original (2000) note: Cj1681c, cysQ, probable cysQ protein homolog, len: 254 aa; similar to e.g. CYSQ_ECOLI CYSQ protein (246 aa), fasta scores; opt: 421 z-score: 500.9 E(): 1.4e-20, 32.4% identity in 247 aa overlap. No Hp match. Contains Pfam match to entry PF00459 inositol_P,Inositol monophosphatase family, and PS00629 Inositol monophosphatase family signature 1. Functional classification - Central intermediary metabolism - Sulphur metabolism; PMID:1729235, PMID:7493934; CysQ protein 1603903 cysQ 905956 cysQ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CysQ protein YP_002345048.1 1603139 R 192222 CDS YP_002345049.1 218563269 905957 complement(1603983..1605251) 1 NC_002163.1 Original (2000) note: Cj1682c, gltA, probable citrate synthase, len: 422 aa; similar to many e.g. CISY_PSEAE citrate synthase (EC 4.1.3.7) (428 aa), fasta scores; opt: 1520 z-score: 1734.6 E(): 0, 53.8% identity in 405 aa overlap. 52.8% identity to HP0026. Contains PS00480 Citrate synthase signature, and Pfam match to entry PF00285 citrate_synt, Citrate synthase; Updated (2006) note: Characterised within Pseudomonas aeruginosa with acceptable identity score. Appropriate motifs present. not added to product function. EC number has been updated. Functional classification - Energy metabolism - Tricarboxylic acid cycle; PMID:2507528; citrate synthase 1605251 gltA 905957 gltA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 citrate synthase YP_002345049.1 1603983 R 192222 CDS YP_002345050.1 218563270 905958 complement(1605366..1606541) 1 NC_002163.1 Original (2000) note: Cj1684c, probable transmembrane transport protein, len: 391 aa; simlar to many predicted Na+/H+ antiporters, and to KEFB_ECOLI Glutathione-regulated potassium-efflux system protein (601 aa), fasta scores; opt: 197 z-score: 237.9 E(): 6.2e-06,21.9% identity in 324 aa overlap, and NAPA_ENTHR Na(+)/H(+) antiporter (383 aa), blastp scores; E= 3.1e-10,22% identity in 372 aa overlap. 35.9% identity to HP1183 (called NA+/H+ antiporter (napA) on basis of match to NAPA_ENTHR); Updated (2006) note: Eleven probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. No specific characterisation yet with acceptable identity score. kept within product function. Functional classification - Transport/binding proteins - Other; transmembrane transport protein 1606541 905958 Cj1684c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 transmembrane transport protein YP_002345050.1 1605366 R 192222 CDS YP_002345051.1 218563271 905959 complement(1606522..1607358) 1 NC_002163.1 catalyzes the formation of biotin from dethiobiotin and sulfur; biotin synthase 1607358 bioB 905959 bioB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 biotin synthase YP_002345051.1 1606522 R 192222 CDS YP_002345052.1 218563272 905960 complement(1607360..1609462) 1 NC_002163.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1609462 topA 905960 topA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 DNA topoisomerase I YP_002345052.1 1607360 R 192222 CDS YP_002345053.1 218563273 905961 1609657..1610928 1 NC_002163.1 Original (2000) note: Cj1687, possible efflux protein, len: 423 aa; similar to members of the major facilitator family e.g. NORA_STAAU quinolone resistance NORA protein (388 aa), fasta scores; opt: 333 z-score: 386.0 E(): 3.5e-14, 23.1% identity in 350 aa overlap, and BMR1_BACSU multidrug resistance protein 1 (389 aa), fasta scores; opt: 282 z-score: 327.8 E(): 6.1e-11, 24.6% identity in 305 aa overlap. No Hp match. Contains Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporters; Updated (2006) note: Pfam domain PF07690 Major Facilitator Superfamily identified within CDS. Also,twelve probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. No specific characterisation with acceptable identity score has been carried out yet. Literature search identified paper giving further clues to product function. Functional classification - Antibiotic resistance; PMID:16048946; efflux protein 1610928 905961 Cj1687 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 efflux protein YP_002345053.1 1609657 D 192222 CDS YP_002345054.1 218563274 905962 complement(1610956..1612221) 1 NC_002163.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 1612221 secY 905962 secY Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 preprotein translocase subunit SecY YP_002345054.1 1610956 R 192222 CDS YP_002345055.1 218563275 905963 complement(1612221..1612613) 1 NC_002163.1 late assembly protein; 50S ribosomal protein L15 1612613 rplO 905963 rplO Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L15 YP_002345055.1 1612221 R 192222 CDS YP_002345056.1 218563276 905964 complement(1612618..1613061) 1 NC_002163.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 1613061 rpsE 905964 rpsE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S5 YP_002345056.1 1612618 R 192222 CDS YP_002345057.1 218563277 905965 complement(1613073..1613429) 1 NC_002163.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 1613429 rplR 905965 rplR Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L18 YP_002345057.1 1613073 R 192222 CDS YP_002345058.1 218563278 905966 complement(1613439..1613975) 1 NC_002163.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 1613975 rplF 905966 rplF Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L6 YP_002345058.1 1613439 R 192222 CDS YP_002345059.1 218563279 905967 complement(1614054..1614449) 1 NC_002163.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 1614449 rpsH 905967 rpsH Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S8 YP_002345059.1 1614054 R 192222 CDS YP_002345060.1 218563280 905968 complement(1614459..1614644) 1 NC_002163.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 1614644 rpsN 905968 rpsN Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S14 YP_002345060.1 1614459 R 192222 CDS YP_002345061.1 218563281 905969 complement(1614646..1615191) 1 NC_002163.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 1615191 rplE 905969 rplE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L5 YP_002345061.1 1614646 R 192222 CDS YP_002345062.1 218563282 905970 complement(1615195..1615428) 1 NC_002163.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 1615428 rplX 905970 rplX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L24 YP_002345062.1 1615195 R 192222 CDS YP_002345063.1 218563283 905971 complement(1615428..1615796) 1 NC_002163.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 1615796 rplN 905971 rplN Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L14 YP_002345063.1 1615428 R 192222 CDS YP_002345064.1 218563284 905972 complement(1615796..1616047) 1 NC_002163.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 1616047 rpsQ 905972 rpsQ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S17 YP_002345064.1 1615796 R 192222 CDS YP_002345065.1 218563285 905973 complement(1616057..1616242) 1 NC_002163.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 1616242 rpmC 905973 rpmC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L29 YP_002345065.1 1616057 R 192222 CDS YP_002345066.1 218563286 905974 complement(1616229..1616654) 1 NC_002163.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 1616654 rplP 905974 rplP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L16 YP_002345066.1 1616229 R 192222 CDS YP_002345067.1 218563287 905975 complement(1616657..1617358) 1 NC_002163.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 1617358 rpsC 905975 rpsC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S3 YP_002345067.1 1616657 R 192222 CDS YP_002345068.1 218563288 905976 complement(1617358..1617783) 1 NC_002163.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 1617783 rplV 905976 rplV Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L22 YP_002345068.1 1617358 R 192222 CDS YP_002345069.1 218563289 905977 complement(1617794..1618075) 1 NC_002163.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 1618075 rpsS 905977 rpsS Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S19 YP_002345069.1 1617794 R 192222 CDS YP_002345070.1 218563290 905978 complement(1618077..1618907) 1 NC_002163.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 1618907 rplB 905978 rplB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L2 YP_002345070.1 1618077 R 192222 CDS YP_002345071.1 218563291 905979 complement(1618909..1619190) 1 NC_002163.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 1619190 rplW 905979 rplW Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L23 YP_002345071.1 1618909 R 192222 CDS YP_002345072.1 218563292 905980 complement(1619193..1619807) 1 NC_002163.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 1619807 rplD 905980 rplD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L4 YP_002345072.1 1619193 R 192222 CDS YP_002345073.1 218563293 905981 complement(1619804..1620379) 1 NC_002163.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 1620379 rplC 905981 rplC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 50S ribosomal protein L3 YP_002345073.1 1619804 R 192222 CDS YP_002345074.1 218563294 905982 complement(1620389..1620700) 1 NC_002163.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 1620700 rpsJ 905982 rpsJ Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 30S ribosomal protein S10 YP_002345074.1 1620389 R 192222 CDS YP_002345075.1 218563295 905983 complement(1620899..1621660) 1 NC_002163.1 Original (2000) note: Cj1709c, probable ribosomal pseudouridine synthase, len: 253 aa; similar to e.g. RLUB_BACSU ribosomal large subunit pseudouridine synthase B (EC 4.2.1.70) (229 aa), fasta scores; opt: 338 z-score: 414.2 E(): 9.5e-16, 33.9% identity in 236 aa overlap. 50.4% identity to HP1459. Contains PS01149 RsuA family of pseudouridine synthase signature; Updated (2006) note: Pfam domain PF00849 RNA pseudouridylate synthase and PF01479 S4 domain were identified within CDS. Further support given to product function. Characterisation work within Bacillus subtilis and others with marginal identity scores. kept in product function. Functional classification - Ribosome maturation and modification; PMID:9888802; ribosomal pseudouridine synthase 1621660 905983 Cj1709c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribosomal pseudouridine synthase YP_002345075.1 1620899 R 192222 CDS YP_002345076.1 218563296 905984 complement(1621696..1623690) 1 NC_002163.1 Original (2000) note: Cj1710c, unknown, len: 664 aa; similar to hypothetical proteins e.g. YKQC_BACSU (555 aa), fasta scores; opt: 1429 z-score: 1605.6 E(): 0, 39.5% identity in 544 aa overlap. N-terminal 100 aa is evry hydrophilic, and is conserved only with the Hp homolog and YOR4_CORGL (645 aa), fasta scores; opt: 1223 z-score: 1373.2 E(): 0, 34.4% identity in 613 aa overlap. 55.3% identity to HP1430. Contains S01292 Uncharacterized protein family UPF0036 signature, and fam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily; Updated (2006) note: Pfam domains PF07521 RNA-metabolising metallo-beta-lactamase and PF00753 Metallo-beta-lactamase superfamily identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out yet with acceptable simiarity score. Thus, kept within product function. Functional classification -Misc; metallo-beta-lactamase family protein 1623690 905984 Cj1710c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 metallo-beta-lactamase family protein YP_002345076.1 1621696 R 192222 CDS YP_002345077.1 218563297 905985 complement(1623659..1624459) 1 NC_002163.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1624459 ksgA 905985 ksgA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 dimethyladenosine transferase YP_002345077.1 1623659 R 192222 CDS YP_002345078.1 218563298 905986 1624541..1625077 1 NC_002163.1 Original (2000) note: Cj1712, unknown, len: 178 aa; 40.9% identity to HP1530 (called purine nucleoside phosphorylase (punB). Functional classification -Conserved hypothetical proteins; hypothetical protein 1625077 905986 Cj1712 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002345078.1 1624541 D 192222 CDS YP_002345079.1 218563299 905987 1625100..1626170 1 NC_002163.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 1626170 905987 Cj1713 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 ribosomal RNA large subunit methyltransferase N YP_002345079.1 1625100 D 192222 CDS YP_002345080.1 218563300 905988 1626167..1626265 1 NC_002163.1 Original (2000) note: Cj1714, small hydrophobic protein, len: 32 aa; no Hp match; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Unknown; hypothetical protein 1626265 905988 Cj1714 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002345080.1 1626167 D 192222 CDS YP_002345081.1 218563301 905992 1626807..1627337 1 NC_002163.1 Original (2000) note: Cj1715, possible acetyltransferase, len: 176 aa; similar to several plasmid- or integron-encoded genes e.g. STA_ECOLI streptothricin acetyltransferase (174 aa), fasta scores; opt: 149 z-score: 192.6 E(): 0.0021, 21.7% identity in 161 aa overlap, and TR:P75025 (EMBL:P75025) plasmid PVS1 hypothetical protein (166 aa), fasta scores; opt: 201 z-score: 255.1 E(): 6.9e-07, 26.1% identity in 161 aa overlap. Also simlilar to TR:O31513 (EMBL:Z99107) Bacillus subtilis chromosomal YESJ protein (180 aa), fasta scores; opt: 157 z-score: 202.0 E(): 0.00063, 20.6% identity in 155 aa overlap. No Hp match. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family; Updated (2006) note: Specific characterisation with acceptable identity score has not been carried out yet. Thus, kept within product function. Functional classification - Antibiotic resistance; acetyltransferase 1627337 905992 Cj1715 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 acetyltransferase YP_002345081.1 1626807 D 192222 CDS YP_002345082.1 218563302 905993 complement(1627317..1627919) 1 NC_002163.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 1627919 leuD 905993 leuD Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 isopropylmalate isomerase small subunit YP_002345082.1 1627317 R 192222 CDS YP_002345083.1 218563303 905994 complement(1627921..1629333) 1 NC_002163.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 1629333 leuC 905994 leuC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 isopropylmalate isomerase large subunit YP_002345083.1 1627921 R 192222 CDS YP_002345084.1 218563304 905995 complement(1629320..1630396) 1 NC_002163.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 1630396 leuB 905995 leuB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 3-isopropylmalate dehydrogenase YP_002345084.1 1629320 R 192222 CDS YP_002345085.1 218563305 905996 complement(1630393..1631928) 1 NC_002163.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 1631928 leuA 905996 leuA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 2-isopropylmalate synthase YP_002345085.1 1630393 R 192222 CDS YP_002345086.1 218563306 905997 1632248..1632877 1 NC_002163.1 Original (2000) note: Cj1720, unknown, len: 209 aa; no Hp match. Functional classification - Unknown; hypothetical protein 1632877 905997 Cj1720 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002345086.1 1632248 D 192222 CDS YP_002345087.1 218563307 905998 complement(1632901..1633545) 1 NC_002163.1 Original (2000) note: Cj1721c, possible outer membrane protein, len: 214 aa; very weak similarity to several e.g. TR:P95343 (EMBL:U52069) Neisseria gonorrhoeae outer membrane protein precursor (174 aa), blastp scores; E= 0.0043, 29% identity in 176 aa overlap. Contains probable N-terminal signal sequence. 22.3% identity to HP0706 (outer membrane protein (omp15)). Functional classification - Membranes, lipoproteins and porins; outer membrane protein 1633545 905998 Cj1721c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 outer membrane protein YP_002345087.1 1632901 R 192222 CDS YP_002345088.1 218563308 905999 complement(1633791..1633892) 1 NC_002163.1 Original (2000) note: Cj1722c, unknown, len: 33 aa; no Hp match. Similar to the N-termini of predicted periplasmic proteins Cj1626c (53.1% identity in 32 aa overlap), and Cj1004 (46.2% identity in 26 aa overlap). Functional classification - Unknown; hypothetical protein 1633892 905999 Cj1722c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002345088.1 1633791 R 192222 CDS YP_002345089.1 218563309 906000 complement(1633895..1634119) 1 NC_002163.1 Original (2000) note: Cj1723c, probable periplasmic protein, len: 74 aa; no Hp match. Contains probable N-terminal signal sequence. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1634119 906000 Cj1723c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002345089.1 1633895 R 192222 CDS YP_002345090.1 218563310 905900 complement(1634296..1634679) 1 NC_002163.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 1634679 905900 Cj1724c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 7-cyano-7-deazaguanine reductase YP_002345090.1 1634296 R 192222 CDS YP_002345091.1 218563311 905202 1634839..1635438 1 NC_002163.1 Original (2000) note: Cj1725, probable periplasmic protein, len: 199 aa; similar to TR:O66724 (EMBL:AE000688) Aquifex aeolicus AQ_407 (203 aa), fasta scores; opt: 411 z-score: 483.0 E(): 1.4e-19, 34.0% identity in 203 aa overlap. No Hp match. Functional classification -Miscellaneous periplasmic proteins; periplasmic protein 1635438 905202 Cj1725 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 periplasmic protein YP_002345091.1 1634839 D 192222 CDS YP_002345092.1 218563312 906001 complement(1635443..1636324) 1 NC_002163.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 1636324 metA 906001 metA Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 homoserine O-succinyltransferase YP_002345092.1 1635443 R 192222 CDS YP_002345093.1 218563313 906002 complement(1636407..1637678) 1 NC_002163.1 Original (2000) note: Cj1727c, metY, possible O-acetylhomoserine (thiol)-lyase, len: 423 aa; TR:P94890 (EMBL:Y10744) Leptospira meyeri O-acetylhomoserine sulfhydrylase (metY) (442 aa), fasta scores; opt: 1198 z-score: 1372.4 E(): 0, 43.0% identity in 433 aa overlap,and CYSD_EMENI O-acetylhomoserine (thiol)-lyase (EC 4.2.99.10) (437 aa), fasta scores; opt: 1001 z-score: 1147.5 E(): 0, 39.4% identity in 419 aa overlap. No Hp ortholog. Also similar to Cj1393 metC (30.0% identity in 363 aa overlap). Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Gamma-family of PLP-dependent enzymes; Updated (2006) note: No specific characterisation in related bacteria with acceptable identity score. kept within product function. Functional classification - Amino acid biosynthesis - Aspartate family; O-acetylhomoserine (thiol)-lyase 1637678 metB 906002 metB Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 O-acetylhomoserine (thiol)-lyase YP_002345093.1 1636407 R 192222 CDS YP_002345094.1 218563314 906003 complement(1637923..1638078) 1 NC_002163.1 Original (2000) note: Cj1728c, small hydrophobic protein, len: 51 aa; no Hp match. Some similarity to Cj1203c (33.3% identity in 42 aa overlap); Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Unknown; hypothetical protein 1638078 906003 Cj1728c Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 hypothetical protein YP_002345094.1 1637923 R 192222 CDS YP_002345095.1 218563315 906004 complement(1638104..1640701) 1 NC_002163.1 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1640701 flgE 906004 flgE Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 flagellar hook protein FlgE YP_002345095.1 1638104 R 192222 CDS YP_002345096.1 218563316 906005 complement(1640904..1641386) 1 NC_002163.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1641386 ruvC 906005 ruvC Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Holliday junction resolvase YP_002345096.1 1640904 R 192222 CDS