-- dump date 20140619_022048 -- class Genbank::misc_feature -- table misc_feature_note -- id note 195099000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 195099000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099000003 Walker A motif; other site 195099000004 ATP binding site [chemical binding]; other site 195099000005 Walker B motif; other site 195099000006 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 195099000007 DnaA box-binding interface [nucleotide binding]; other site 195099000008 DNA polymerase III subunit beta; Validated; Region: PRK05643 195099000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 195099000010 putative DNA binding surface [nucleotide binding]; other site 195099000011 dimer interface [polypeptide binding]; other site 195099000012 beta-clamp/clamp loader binding surface; other site 195099000013 beta-clamp/translesion DNA polymerase binding surface; other site 195099000014 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 195099000015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195099000016 Mg2+ binding site [ion binding]; other site 195099000017 G-X-G motif; other site 195099000018 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 195099000019 anchoring element; other site 195099000020 dimer interface [polypeptide binding]; other site 195099000021 ATP binding site [chemical binding]; other site 195099000022 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 195099000023 active site 195099000024 putative metal-binding site [ion binding]; other site 195099000025 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 195099000026 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 195099000027 sulfite oxidase; Provisional; Region: PLN00177 195099000028 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 195099000029 Moco binding site; other site 195099000030 metal coordination site [ion binding]; other site 195099000031 dimerization interface [polypeptide binding]; other site 195099000032 Predicted permease [General function prediction only]; Region: COG2056 195099000033 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 195099000034 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 195099000035 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 195099000036 active site 195099000037 dimer interface [polypeptide binding]; other site 195099000038 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 195099000039 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 195099000040 active site 195099000041 FMN binding site [chemical binding]; other site 195099000042 substrate binding site [chemical binding]; other site 195099000043 3Fe-4S cluster binding site [ion binding]; other site 195099000044 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 195099000045 domain interface; other site 195099000046 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 195099000047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 195099000048 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 195099000049 RNA/DNA hybrid binding site [nucleotide binding]; other site 195099000050 active site 195099000051 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 195099000052 Helix-hairpin-helix motif; Region: HHH; pfam00633 195099000053 Rubrerythrin [Energy production and conversion]; Region: COG1592 195099000054 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 195099000055 binuclear metal center [ion binding]; other site 195099000056 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 195099000057 iron binding site [ion binding]; other site 195099000058 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 195099000059 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 195099000060 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 195099000061 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 195099000062 Ligand Binding Site [chemical binding]; other site 195099000063 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 195099000064 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 195099000065 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 195099000066 dimer interface [polypeptide binding]; other site 195099000067 putative CheW interface [polypeptide binding]; other site 195099000068 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 195099000069 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 195099000070 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 195099000071 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 195099000072 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 195099000073 active site 195099000074 adenylosuccinate lyase; Provisional; Region: PRK08470 195099000075 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 195099000076 tetramer interface [polypeptide binding]; other site 195099000077 active site 195099000078 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 195099000079 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 195099000080 ATP cone domain; Region: ATP-cone; pfam03477 195099000081 Class I ribonucleotide reductase; Region: RNR_I; cd01679 195099000082 active site 195099000083 dimer interface [polypeptide binding]; other site 195099000084 catalytic residues [active] 195099000085 effector binding site; other site 195099000086 R2 peptide binding site; other site 195099000087 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 195099000088 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 195099000089 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 195099000090 CTP synthetase; Validated; Region: pyrG; PRK05380 195099000091 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 195099000092 Catalytic site [active] 195099000093 active site 195099000094 UTP binding site [chemical binding]; other site 195099000095 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 195099000096 active site 195099000097 putative oxyanion hole; other site 195099000098 catalytic triad [active] 195099000099 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 195099000100 DHH family; Region: DHH; pfam01368 195099000101 DHHA1 domain; Region: DHHA1; pfam02272 195099000102 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 195099000103 active site 195099000104 homodimer interface [polypeptide binding]; other site 195099000105 homotetramer interface [polypeptide binding]; other site 195099000106 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 195099000107 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 195099000108 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 195099000109 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 195099000110 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 195099000111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 195099000112 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 195099000113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099000114 putative substrate translocation pore; other site 195099000115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 195099000116 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 195099000117 Cytochrome c [Energy production and conversion]; Region: COG3258 195099000118 Cytochrome c; Region: Cytochrom_C; pfam00034 195099000119 Cytochrome c; Region: Cytochrom_C; pfam00034 195099000120 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 195099000121 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 195099000122 G1 box; other site 195099000123 putative GEF interaction site [polypeptide binding]; other site 195099000124 GTP/Mg2+ binding site [chemical binding]; other site 195099000125 Switch I region; other site 195099000126 G2 box; other site 195099000127 G3 box; other site 195099000128 Switch II region; other site 195099000129 G4 box; other site 195099000130 G5 box; other site 195099000131 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 195099000132 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 195099000133 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 195099000134 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 195099000135 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 195099000136 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 195099000137 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 195099000138 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 195099000139 Protein of unknown function (DUF342); Region: DUF342; pfam03961 195099000140 Hemerythrin; Region: Hemerythrin; cd12107 195099000141 Fe binding site [ion binding]; other site 195099000142 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 195099000143 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 195099000144 Ligand Binding Site [chemical binding]; other site 195099000145 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 195099000146 Beta-lactamase; Region: Beta-lactamase; cl17358 195099000147 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 195099000148 putative active site [active] 195099000149 flagellar motor switch protein FliY; Validated; Region: PRK08432 195099000150 flagellar motor switch protein FliN; Region: fliN; TIGR02480 195099000151 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 195099000152 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 195099000153 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 195099000154 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 195099000155 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 195099000156 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 195099000157 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 195099000158 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 195099000159 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 195099000160 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 195099000161 catalytic center binding site [active] 195099000162 ATP binding site [chemical binding]; other site 195099000163 Dehydroquinase class II; Region: DHquinase_II; pfam01220 195099000164 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 195099000165 trimer interface [polypeptide binding]; other site 195099000166 active site 195099000167 dimer interface [polypeptide binding]; other site 195099000168 chlorohydrolase; Provisional; Region: PRK08418 195099000169 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 195099000170 active site 195099000171 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 195099000172 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 195099000173 tandem repeat interface [polypeptide binding]; other site 195099000174 oligomer interface [polypeptide binding]; other site 195099000175 active site residues [active] 195099000176 Uncharacterized conserved protein [Function unknown]; Region: COG1556 195099000177 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 195099000178 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 195099000179 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 195099000180 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 195099000181 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 195099000182 Cysteine-rich domain; Region: CCG; pfam02754 195099000183 Cysteine-rich domain; Region: CCG; pfam02754 195099000184 L-lactate permease; Region: Lactate_perm; cl00701 195099000185 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 195099000186 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 195099000187 CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081 195099000188 putative catalytic site [active] 195099000189 CdtC interface [polypeptide binding]; other site 195099000190 heterotrimer interface [polypeptide binding]; other site 195099000191 CdtA interface [polypeptide binding]; other site 195099000192 putative metal binding site [ion binding]; other site 195099000193 putative phosphate binding site [ion binding]; other site 195099000194 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 195099000195 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 195099000196 putative sugar binding sites [chemical binding]; other site 195099000197 Q-X-W motif; other site 195099000198 Cytochrome bd-type quinol oxidase, subunit 1 [Energy production and conversion]; Region: CydA; COG1271 195099000199 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 195099000200 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 195099000201 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 195099000202 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 195099000203 aspartate racemase; Region: asp_race; TIGR00035 195099000204 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 195099000205 ligand binding site [chemical binding]; other site 195099000206 active site 195099000207 UGI interface [polypeptide binding]; other site 195099000208 catalytic site [active] 195099000209 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 195099000210 Aspartase; Region: Aspartase; cd01357 195099000211 active sites [active] 195099000212 tetramer interface [polypeptide binding]; other site 195099000213 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 195099000214 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 195099000215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 195099000216 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 195099000217 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 195099000218 putative dimer interface [polypeptide binding]; other site 195099000219 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 195099000220 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 195099000221 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 195099000222 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 195099000223 GTPase CgtA; Reviewed; Region: obgE; PRK12299 195099000224 GTP1/OBG; Region: GTP1_OBG; pfam01018 195099000225 Obg GTPase; Region: Obg; cd01898 195099000226 G1 box; other site 195099000227 GTP/Mg2+ binding site [chemical binding]; other site 195099000228 Switch I region; other site 195099000229 G2 box; other site 195099000230 G3 box; other site 195099000231 Switch II region; other site 195099000232 G4 box; other site 195099000233 G5 box; other site 195099000234 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 195099000235 nucleotide binding site [chemical binding]; other site 195099000236 homotetrameric interface [polypeptide binding]; other site 195099000237 putative phosphate binding site [ion binding]; other site 195099000238 putative allosteric binding site; other site 195099000239 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 195099000240 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 195099000241 putative active site [active] 195099000242 substrate binding site [chemical binding]; other site 195099000243 putative cosubstrate binding site; other site 195099000244 catalytic site [active] 195099000245 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 195099000246 substrate binding site [chemical binding]; other site 195099000247 biotin--protein ligase; Provisional; Region: PRK08477 195099000248 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 195099000249 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 195099000250 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 195099000251 P-loop; other site 195099000252 Magnesium ion binding site [ion binding]; other site 195099000253 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 195099000254 Magnesium ion binding site [ion binding]; other site 195099000255 ParB-like nuclease domain; Region: ParB; smart00470 195099000256 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 195099000257 F0F1 ATP synthase subunit B'; Validated; Region: PRK08476 195099000258 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 195099000259 F0F1 ATP synthase subunit B; Validated; Region: PRK08475 195099000260 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 195099000261 F0F1 ATP synthase subunit delta; Validated; Region: PRK08474 195099000262 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 195099000263 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 195099000264 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 195099000265 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 195099000266 beta subunit interaction interface [polypeptide binding]; other site 195099000267 Walker A motif; other site 195099000268 ATP binding site [chemical binding]; other site 195099000269 Walker B motif; other site 195099000270 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 195099000271 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 195099000272 core domain interface [polypeptide binding]; other site 195099000273 delta subunit interface [polypeptide binding]; other site 195099000274 epsilon subunit interface [polypeptide binding]; other site 195099000275 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 195099000276 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 195099000277 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 195099000278 alpha subunit interaction interface [polypeptide binding]; other site 195099000279 Walker A motif; other site 195099000280 ATP binding site [chemical binding]; other site 195099000281 Walker B motif; other site 195099000282 inhibitor binding site; inhibition site 195099000283 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 195099000284 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 195099000285 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 195099000286 gamma subunit interface [polypeptide binding]; other site 195099000287 epsilon subunit interface [polypeptide binding]; other site 195099000288 LBP interface [polypeptide binding]; other site 195099000289 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 195099000290 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 195099000291 TolR protein; Region: tolR; TIGR02801 195099000292 TonB C terminal; Region: TonB_2; pfam13103 195099000293 translocation protein TolB; Provisional; Region: tolB; PRK04043 195099000294 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 195099000295 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 195099000296 ligand binding site [chemical binding]; other site 195099000297 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 195099000298 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 195099000299 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 195099000300 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 195099000301 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 195099000302 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 195099000303 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 195099000304 Ligand Binding Site [chemical binding]; other site 195099000305 Isochorismatase family; Region: Isochorismatase; pfam00857 195099000306 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 195099000307 catalytic triad [active] 195099000308 conserved cis-peptide bond; other site 195099000309 putative recombination protein RecO; Provisional; Region: PRK13908 195099000310 metal-binding heat shock protein; Provisional; Region: PRK00016 195099000311 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 195099000312 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 195099000313 FMN binding site [chemical binding]; other site 195099000314 active site 195099000315 catalytic residues [active] 195099000316 substrate binding site [chemical binding]; other site 195099000317 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 195099000318 Uncharacterized conserved protein [Function unknown]; Region: COG1576 195099000319 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 195099000320 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 195099000321 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 195099000322 Putative fructose-1,6-bisphosphatase or related enzymes of inositol monophosphatase family. These are Mg++ dependent phosphatases. Members in this family may have fructose-1,6-bisphosphatase and/or inositol-monophosphatase activity. Fructose-1; Region: Arch_FBPase_2; cd01642 195099000323 putative active site [active] 195099000324 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 195099000325 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 195099000326 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 195099000327 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 195099000328 Surface antigen; Region: Bac_surface_Ag; pfam01103 195099000329 prephenate dehydrogenase; Validated; Region: PRK08507 195099000330 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 195099000331 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 195099000332 Peptidase family M23; Region: Peptidase_M23; pfam01551 195099000333 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 195099000334 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 195099000335 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 195099000336 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 195099000337 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 195099000338 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 195099000339 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 195099000340 translation initiation factor IF-2; Region: IF-2; TIGR00487 195099000341 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 195099000342 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 195099000343 G1 box; other site 195099000344 putative GEF interaction site [polypeptide binding]; other site 195099000345 GTP/Mg2+ binding site [chemical binding]; other site 195099000346 Switch I region; other site 195099000347 G2 box; other site 195099000348 G3 box; other site 195099000349 Switch II region; other site 195099000350 G4 box; other site 195099000351 G5 box; other site 195099000352 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 195099000353 Translation-initiation factor 2; Region: IF-2; pfam11987 195099000354 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 195099000355 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 195099000356 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 195099000357 Sm and related proteins; Region: Sm_like; cl00259 195099000358 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 195099000359 putative oligomer interface [polypeptide binding]; other site 195099000360 putative RNA binding site [nucleotide binding]; other site 195099000361 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 195099000362 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 195099000363 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 195099000364 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 195099000365 dimer interface [polypeptide binding]; other site 195099000366 putative PBP binding regions; other site 195099000367 ABC-ATPase subunit interface; other site 195099000368 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 195099000369 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 195099000370 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 195099000371 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 195099000372 putative metal binding residues [ion binding]; other site 195099000373 Cache domain; Region: Cache_1; pfam02743 195099000374 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 195099000375 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 195099000376 dimer interface [polypeptide binding]; other site 195099000377 putative CheW interface [polypeptide binding]; other site 195099000378 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 195099000379 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 195099000380 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 195099000381 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 195099000382 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 195099000383 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 195099000384 catalytic residues [active] 195099000385 Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792 195099000386 homoserine dehydrogenase; Provisional; Region: PRK06349 195099000387 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 195099000388 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 195099000389 aspartate aminotransferase; Provisional; Region: PRK08636 195099000390 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 195099000391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099000392 homodimer interface [polypeptide binding]; other site 195099000393 catalytic residue [active] 195099000394 Helix-turn-helix domain; Region: HTH_25; pfam13413 195099000395 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 195099000396 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 195099000397 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 195099000398 Predicted methyltransferases [General function prediction only]; Region: COG0313 195099000399 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 195099000400 putative SAM binding site [chemical binding]; other site 195099000401 putative homodimer interface [polypeptide binding]; other site 195099000402 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 195099000403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 195099000404 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 195099000405 queuosine biosynthesis protein QueD; Region: queuosine_QueD; TIGR03367 195099000406 active site 195099000407 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 195099000408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195099000409 FeS/SAM binding site; other site 195099000410 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 195099000411 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195099000412 FeS/SAM binding site; other site 195099000413 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 195099000414 prenyltransferase; Reviewed; Region: ubiA; PRK12874 195099000415 UbiA prenyltransferase family; Region: UbiA; pfam01040 195099000416 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 195099000417 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 195099000418 Predicted membrane protein [Function unknown]; Region: COG1971 195099000419 Domain of unknown function DUF; Region: DUF204; pfam02659 195099000420 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 195099000421 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 195099000422 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 195099000423 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 195099000424 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 195099000425 NAD(P) binding pocket [chemical binding]; other site 195099000426 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 195099000427 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 195099000428 Walker A/P-loop; other site 195099000429 ATP binding site [chemical binding]; other site 195099000430 Q-loop/lid; other site 195099000431 ABC transporter signature motif; other site 195099000432 Walker B; other site 195099000433 D-loop; other site 195099000434 H-loop/switch region; other site 195099000435 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 195099000436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099000437 dimer interface [polypeptide binding]; other site 195099000438 conserved gate region; other site 195099000439 putative PBP binding loops; other site 195099000440 ABC-ATPase subunit interface; other site 195099000441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099000442 dimer interface [polypeptide binding]; other site 195099000443 conserved gate region; other site 195099000444 putative PBP binding loops; other site 195099000445 ABC-ATPase subunit interface; other site 195099000446 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 195099000447 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 195099000448 Uncharacterized iron-regulated protein [Function unknown]; Region: PhuW; COG3016 195099000449 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 195099000450 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 195099000451 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 195099000452 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 195099000453 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 195099000454 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 195099000455 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 195099000456 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 195099000457 Domain of unknown function DUF21; Region: DUF21; pfam01595 195099000458 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 195099000459 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 195099000460 Transporter associated domain; Region: CorC_HlyC; smart01091 195099000461 Predicted kinase [General function prediction only]; Region: COG4639 195099000462 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 195099000463 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 195099000464 active site 195099000465 metal binding site [ion binding]; metal-binding site 195099000466 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 195099000467 PhnA protein; Region: PhnA; pfam03831 195099000468 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 195099000469 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 195099000470 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 195099000471 active site 195099000472 substrate binding site [chemical binding]; other site 195099000473 cosubstrate binding site; other site 195099000474 catalytic site [active] 195099000475 Uncharacterized conserved protein [Function unknown]; Region: COG0062 195099000476 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 195099000477 putative substrate binding site [chemical binding]; other site 195099000478 putative ATP binding site [chemical binding]; other site 195099000479 Uncharacterized conserved protein [Function unknown]; Region: COG1432 195099000480 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 195099000481 putative metal binding site [ion binding]; other site 195099000482 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 195099000483 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 195099000484 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 195099000485 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 195099000486 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 195099000487 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 195099000488 active site 195099000489 catalytic residues [active] 195099000490 metal binding site [ion binding]; metal-binding site 195099000491 Clp protease; Region: CLP_protease; pfam00574 195099000492 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 195099000493 oligomer interface [polypeptide binding]; other site 195099000494 active site residues [active] 195099000495 trigger factor; Provisional; Region: tig; PRK01490 195099000496 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 195099000497 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 195099000498 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 195099000499 homodecamer interface [polypeptide binding]; other site 195099000500 GTP cyclohydrolase I; Provisional; Region: PLN03044 195099000501 active site 195099000502 putative catalytic site residues [active] 195099000503 zinc binding site [ion binding]; other site 195099000504 GTP-CH-I/GFRP interaction surface; other site 195099000505 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 195099000506 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 195099000507 Walker A motif/ATP binding site; other site 195099000508 Walker B motif; other site 195099000509 amidophosphoribosyltransferase; Provisional; Region: PRK08525 195099000510 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 195099000511 active site 195099000512 tetramer interface [polypeptide binding]; other site 195099000513 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195099000514 active site 195099000515 dihydrodipicolinate reductase; Provisional; Region: PRK00048 195099000516 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 195099000517 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 195099000518 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 195099000519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099000520 Walker A motif; other site 195099000521 ATP binding site [chemical binding]; other site 195099000522 Walker B motif; other site 195099000523 arginine finger; other site 195099000524 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 195099000525 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 195099000526 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 195099000527 Predicted membrane protein [Function unknown]; Region: COG1297 195099000528 putative oligopeptide transporter, OPT family; Region: TIGR00733 195099000529 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 195099000530 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 195099000531 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 195099000532 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 195099000533 active site 195099000534 dimer interface [polypeptide binding]; other site 195099000535 motif 1; other site 195099000536 motif 2; other site 195099000537 motif 3; other site 195099000538 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 195099000539 anticodon binding site; other site 195099000540 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 195099000541 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 195099000542 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 195099000543 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 195099000544 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 195099000545 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 195099000546 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 195099000547 lysogenic Mu-like bacteriophage; target site duplication = TATGC with terminal inverted repeats TG..CA; CJE_PHAGE01 195099000548 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 195099000549 Predicted transcriptional regulator [Transcription]; Region: COG2932 195099000550 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 195099000551 Catalytic site [active] 195099000552 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 195099000553 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 195099000554 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 195099000555 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 195099000556 Phage tail tube protein FII; Region: Phage_tube; cl01390 195099000557 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 195099000558 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 195099000559 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 195099000560 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 195099000561 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 195099000562 Baseplate J-like protein; Region: Baseplate_J; cl01294 195099000563 Baseplate J-like protein; Region: Baseplate_J; pfam04865 195099000564 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 195099000565 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 195099000566 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 195099000567 Peptidase M15; Region: Peptidase_M15_3; cl01194 195099000568 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 195099000569 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 195099000570 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 195099000571 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 195099000572 Protein of unknown function (DUF1804); Region: DUF1804; pfam08822 195099000573 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 195099000574 Protein of unknown function (DUF935); Region: DUF935; pfam06074 195099000575 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 195099000576 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 195099000577 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 195099000578 Phage Tail Protein X; Region: Phage_tail_X; cl02088 195099000579 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 195099000580 Mor transcription activator family; Region: Mor; cl02360 195099000581 Endonuclease I; Region: Endonuclease_1; pfam04231 195099000582 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 195099000583 AAA domain; Region: AAA_25; pfam13481 195099000584 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 195099000585 Walker A motif; other site 195099000586 ATP binding site [chemical binding]; other site 195099000587 Walker B motif; other site 195099000588 YopX protein; Region: YopX; pfam09643 195099000589 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 195099000590 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 195099000591 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 195099000592 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 195099000593 DNA binding residues [nucleotide binding] 195099000594 AAA domain; Region: AAA_30; pfam13604 195099000595 AAA domain; Region: AAA_22; pfam13401 195099000596 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 195099000597 Integrase core domain; Region: rve; pfam00665 195099000598 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 195099000599 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 195099000600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 195099000601 non-specific DNA binding site [nucleotide binding]; other site 195099000602 salt bridge; other site 195099000603 sequence-specific DNA binding site [nucleotide binding]; other site 195099000604 Predicted transcriptional regulator [Transcription]; Region: COG2932 195099000605 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 195099000606 Catalytic site [active] 195099000607 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 195099000608 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 195099000609 putative acetyltransferase YhhY; Provisional; Region: PRK10140 195099000610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195099000611 Coenzyme A binding pocket [chemical binding]; other site 195099000612 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 195099000613 feedback inhibition sensing region; other site 195099000614 homohexameric interface [polypeptide binding]; other site 195099000615 nucleotide binding site [chemical binding]; other site 195099000616 N-acetyl-L-glutamate binding site [chemical binding]; other site 195099000617 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 195099000618 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 195099000619 inhibitor-cofactor binding pocket; inhibition site 195099000620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099000621 catalytic residue [active] 195099000622 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 195099000623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195099000624 S-adenosylmethionine binding site [chemical binding]; other site 195099000625 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 195099000626 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 195099000627 trimer interface [polypeptide binding]; other site 195099000628 putative metal binding site [ion binding]; other site 195099000629 putative nicotinate phosphoribosyltransferase; Region: NAPRTase_put; TIGR01513 195099000630 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 195099000631 active site 195099000632 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 195099000633 dimer interface [polypeptide binding]; other site 195099000634 putative radical transfer pathway; other site 195099000635 diiron center [ion binding]; other site 195099000636 tyrosyl radical; other site 195099000637 RDD family; Region: RDD; pfam06271 195099000638 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195099000639 active site 195099000640 ribosome recycling factor; Reviewed; Region: frr; PRK00083 195099000641 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 195099000642 hinge region; other site 195099000643 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 195099000644 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 195099000645 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 195099000646 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 195099000647 active site clefts [active] 195099000648 zinc binding site [ion binding]; other site 195099000649 dimer interface [polypeptide binding]; other site 195099000650 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 195099000651 Mechanosensitive ion channel; Region: MS_channel; pfam00924 195099000652 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 195099000653 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 195099000654 trimerization site [polypeptide binding]; other site 195099000655 active site 195099000656 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 195099000657 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 195099000658 cysteine desulfurase, NifS family, epsilon proteobacteria type; Region: nifS_epsilon; TIGR03403 195099000659 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 195099000660 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 195099000661 catalytic residue [active] 195099000662 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 195099000663 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 195099000664 23S rRNA binding site [nucleotide binding]; other site 195099000665 L21 binding site [polypeptide binding]; other site 195099000666 L13 binding site [polypeptide binding]; other site 195099000667 FIST C domain; Region: FIST_C; pfam10442 195099000668 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 195099000669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099000670 metabolite-proton symporter; Region: 2A0106; TIGR00883 195099000671 putative substrate translocation pore; other site 195099000672 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 195099000673 trimer interface [polypeptide binding]; other site 195099000674 dimer interface [polypeptide binding]; other site 195099000675 putative active site [active] 195099000676 Protein of unknown function (DUF493); Region: DUF493; pfam04359 195099000677 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 195099000678 putative catalytic site [active] 195099000679 putative metal binding site [ion binding]; other site 195099000680 putative phosphate binding site [ion binding]; other site 195099000681 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 195099000682 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 195099000683 Sulfatase; Region: Sulfatase; pfam00884 195099000684 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 195099000685 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 195099000686 active site 195099000687 substrate binding pocket [chemical binding]; other site 195099000688 dimer interface [polypeptide binding]; other site 195099000689 Predicted helicase [General function prediction only]; Region: COG4889 195099000690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195099000691 S-adenosylmethionine binding site [chemical binding]; other site 195099000692 Cache domain; Region: Cache_1; pfam02743 195099000693 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 195099000694 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 195099000695 dimer interface [polypeptide binding]; other site 195099000696 putative CheW interface [polypeptide binding]; other site 195099000697 zinc transporter ZupT; Provisional; Region: PRK04201 195099000698 ZIP Zinc transporter; Region: Zip; pfam02535 195099000699 Cache domain; Region: Cache_1; pfam02743 195099000700 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 195099000701 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 195099000702 dimer interface [polypeptide binding]; other site 195099000703 putative CheW interface [polypeptide binding]; other site 195099000704 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 195099000705 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 195099000706 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 195099000707 SPFH domain / Band 7 family; Region: Band_7; pfam01145 195099000708 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 195099000709 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 195099000710 homodimer interface [polypeptide binding]; other site 195099000711 substrate-cofactor binding pocket; other site 195099000712 catalytic residue [active] 195099000713 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 195099000714 active site 1 [active] 195099000715 dimer interface [polypeptide binding]; other site 195099000716 hexamer interface [polypeptide binding]; other site 195099000717 active site 2 [active] 195099000718 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 195099000719 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 195099000720 catalytic triad [active] 195099000721 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 195099000722 Ligand Binding Site [chemical binding]; other site 195099000723 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 195099000724 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 195099000725 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 195099000726 active site 195099000727 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 195099000728 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 195099000729 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 195099000730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099000731 Walker A motif; other site 195099000732 ATP binding site [chemical binding]; other site 195099000733 Walker B motif; other site 195099000734 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 195099000735 rod shape-determining protein MreB; Provisional; Region: PRK13927 195099000736 MreB and similar proteins; Region: MreB_like; cd10225 195099000737 nucleotide binding site [chemical binding]; other site 195099000738 Mg binding site [ion binding]; other site 195099000739 putative protofilament interaction site [polypeptide binding]; other site 195099000740 RodZ interaction site [polypeptide binding]; other site 195099000741 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 195099000742 rod shape-determining protein MreC; Region: MreC; pfam04085 195099000743 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 195099000744 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 195099000745 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 195099000746 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 195099000747 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 195099000748 ATP-grasp domain; Region: ATP-grasp_4; cl17255 195099000749 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 195099000750 IMP binding site; other site 195099000751 dimer interface [polypeptide binding]; other site 195099000752 interdomain contacts; other site 195099000753 partial ornithine binding site; other site 195099000754 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 195099000755 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 195099000756 putative active site [active] 195099000757 transaldolase; Provisional; Region: PRK03903 195099000758 catalytic residue [active] 195099000759 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 195099000760 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 195099000761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195099000762 motif II; other site 195099000763 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 195099000764 putative CheA interaction surface; other site 195099000765 chemotaxis protein CheA; Provisional; Region: PRK10547 195099000766 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 195099000767 putative binding surface; other site 195099000768 active site 195099000769 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 195099000770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195099000771 ATP binding site [chemical binding]; other site 195099000772 Mg2+ binding site [ion binding]; other site 195099000773 G-X-G motif; other site 195099000774 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 195099000775 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 195099000776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195099000777 active site 195099000778 phosphorylation site [posttranslational modification] 195099000779 intermolecular recognition site; other site 195099000780 dimerization interface [polypeptide binding]; other site 195099000781 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 195099000782 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 195099000783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195099000784 active site 195099000785 phosphorylation site [posttranslational modification] 195099000786 intermolecular recognition site; other site 195099000787 dimerization interface [polypeptide binding]; other site 195099000788 active site 195099000789 metal binding site [ion binding]; metal-binding site 195099000790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2908 195099000791 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 195099000792 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 195099000793 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 195099000794 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 195099000795 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 195099000796 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 195099000797 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 195099000798 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 195099000799 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 195099000800 ATP binding site [chemical binding]; other site 195099000801 substrate interface [chemical binding]; other site 195099000802 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 195099000803 tetramerization interface [polypeptide binding]; other site 195099000804 active site 195099000805 pantoate--beta-alanine ligase; Region: panC; TIGR00018 195099000806 Pantoate-beta-alanine ligase; Region: PanC; cd00560 195099000807 active site 195099000808 ATP-binding site [chemical binding]; other site 195099000809 pantoate-binding site; other site 195099000810 HXXH motif; other site 195099000811 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 195099000812 oligomerization interface [polypeptide binding]; other site 195099000813 active site 195099000814 metal binding site [ion binding]; metal-binding site 195099000815 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 195099000816 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 195099000817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195099000818 Walker A/P-loop; other site 195099000819 ATP binding site [chemical binding]; other site 195099000820 Q-loop/lid; other site 195099000821 ABC transporter signature motif; other site 195099000822 Walker B; other site 195099000823 D-loop; other site 195099000824 H-loop/switch region; other site 195099000825 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 195099000826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099000827 dimer interface [polypeptide binding]; other site 195099000828 conserved gate region; other site 195099000829 putative PBP binding loops; other site 195099000830 ABC-ATPase subunit interface; other site 195099000831 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 195099000832 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 195099000833 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 195099000834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195099000835 S-adenosylmethionine binding site [chemical binding]; other site 195099000836 Protein of unknown function (DUF452); Region: DUF452; cl01062 195099000837 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 195099000838 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 195099000839 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 195099000840 catalytic residue [active] 195099000841 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 195099000842 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 195099000843 inhibitor-cofactor binding pocket; inhibition site 195099000844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099000845 catalytic residue [active] 195099000846 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 195099000847 AAA domain; Region: AAA_26; pfam13500 195099000848 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 195099000849 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 195099000850 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 195099000851 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 195099000852 5S rRNA interface [nucleotide binding]; other site 195099000853 CTC domain interface [polypeptide binding]; other site 195099000854 L16 interface [polypeptide binding]; other site 195099000855 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 195099000856 putative active site [active] 195099000857 catalytic residue [active] 195099000858 Predicted permeases [General function prediction only]; Region: COG0795 195099000859 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 195099000860 diaminopimelate decarboxylase; Region: lysA; TIGR01048 195099000861 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 195099000862 active site 195099000863 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 195099000864 substrate binding site [chemical binding]; other site 195099000865 catalytic residues [active] 195099000866 dimer interface [polypeptide binding]; other site 195099000867 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 195099000868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195099000869 active site 195099000870 motif I; other site 195099000871 motif II; other site 195099000872 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 195099000873 chorismate mutase domain of proteobacterial P-protein, clade 2; Region: CM_P2; TIGR01807 195099000874 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 195099000875 Prephenate dehydratase; Region: PDT; pfam00800 195099000876 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 195099000877 putative L-Phe binding site [chemical binding]; other site 195099000878 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 195099000879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 195099000880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099000881 homodimer interface [polypeptide binding]; other site 195099000882 catalytic residue [active] 195099000883 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 195099000884 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 195099000885 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 195099000886 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 195099000887 FliG C-terminal domain; Region: FliG_C; pfam01706 195099000888 flagellar assembly protein H; Validated; Region: fliH; PRK06669 195099000889 Flagellar assembly protein FliH; Region: FliH; pfam02108 195099000890 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 195099000891 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 195099000892 TPP-binding site; other site 195099000893 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 195099000894 PYR/PP interface [polypeptide binding]; other site 195099000895 dimer interface [polypeptide binding]; other site 195099000896 TPP binding site [chemical binding]; other site 195099000897 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 195099000898 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 195099000899 metal binding site 2 [ion binding]; metal-binding site 195099000900 putative DNA binding helix; other site 195099000901 metal binding site 1 [ion binding]; metal-binding site 195099000902 structural Zn2+ binding site [ion binding]; other site 195099000903 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 195099000904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195099000905 S-adenosylmethionine binding site [chemical binding]; other site 195099000906 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 195099000907 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 195099000908 generic binding surface II; other site 195099000909 generic binding surface I; other site 195099000910 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 195099000911 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 195099000912 homodimer interface [polypeptide binding]; other site 195099000913 substrate-cofactor binding pocket; other site 195099000914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099000915 catalytic residue [active] 195099000916 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 195099000917 homotrimer interaction site [polypeptide binding]; other site 195099000918 putative active site [active] 195099000919 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 195099000920 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 195099000921 dimer interface [polypeptide binding]; other site 195099000922 active site 195099000923 CoA binding pocket [chemical binding]; other site 195099000924 putative phosphate acyltransferase; Provisional; Region: PRK05331 195099000925 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 195099000926 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 195099000927 active site 195099000928 multimer interface [polypeptide binding]; other site 195099000929 Ferredoxin [Energy production and conversion]; Region: COG1146 195099000930 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 195099000931 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 195099000932 dimer interface [polypeptide binding]; other site 195099000933 decamer (pentamer of dimers) interface [polypeptide binding]; other site 195099000934 catalytic triad [active] 195099000935 peroxidatic and resolving cysteines [active] 195099000936 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 195099000937 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 195099000938 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 195099000939 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 195099000940 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 195099000941 ligand binding site [chemical binding]; other site 195099000942 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 195099000943 flagellar motor protein MotA; Validated; Region: PRK08456 195099000944 DNA polymerase I; Provisional; Region: PRK05755 195099000945 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 195099000946 active site 195099000947 metal binding site 1 [ion binding]; metal-binding site 195099000948 putative 5' ssDNA interaction site; other site 195099000949 metal binding site 3; metal-binding site 195099000950 metal binding site 2 [ion binding]; metal-binding site 195099000951 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 195099000952 putative DNA binding site [nucleotide binding]; other site 195099000953 putative metal binding site [ion binding]; other site 195099000954 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 195099000955 active site 195099000956 catalytic site [active] 195099000957 substrate binding site [chemical binding]; other site 195099000958 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 195099000959 active site 195099000960 DNA binding site [nucleotide binding] 195099000961 catalytic site [active] 195099000962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099000963 metabolite-proton symporter; Region: 2A0106; TIGR00883 195099000964 putative substrate translocation pore; other site 195099000965 nuc_hydro_CjNH. Nucleoside hydrolases similar to Campylobacter jejuni nucleoside hydrolase. This group contains eukaryotic and bacterial proteins similar to C. jejuni nucleoside hydrolase. Nucleoside hydrolases cleave the N-glycosidic bond in...; Region: nuc_hydro_CjNH; cd02654 195099000966 active site 195099000967 Predicted membrane protein [Function unknown]; Region: COG1238 195099000968 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 195099000969 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 195099000970 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 195099000971 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 195099000972 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 195099000973 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 195099000974 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 195099000975 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 195099000976 Glutamine amidotransferase class-I; Region: GATase; pfam00117 195099000977 glutamine binding [chemical binding]; other site 195099000978 catalytic triad [active] 195099000979 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 195099000980 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 195099000981 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 195099000982 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 195099000983 active site 195099000984 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 195099000985 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 195099000986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099000987 catalytic residue [active] 195099000988 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 195099000989 substrate binding site [chemical binding]; other site 195099000990 active site 195099000991 catalytic residues [active] 195099000992 heterodimer interface [polypeptide binding]; other site 195099000993 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 195099000994 flagellar motor switch protein; Validated; Region: PRK08433 195099000995 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 195099000996 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 195099000997 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 195099000998 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195099000999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195099001000 active site 195099001001 phosphorylation site [posttranslational modification] 195099001002 intermolecular recognition site; other site 195099001003 dimerization interface [polypeptide binding]; other site 195099001004 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195099001005 DNA binding site [nucleotide binding] 195099001006 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 195099001007 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 195099001008 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 195099001009 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 195099001010 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 195099001011 active site 195099001012 substrate binding site [chemical binding]; other site 195099001013 metal binding site [ion binding]; metal-binding site 195099001014 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 195099001015 lipoprotein signal peptidase; Provisional; Region: PRK14787 195099001016 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 195099001017 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 195099001018 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 195099001019 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 195099001020 Protein export membrane protein; Region: SecD_SecF; cl14618 195099001021 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 195099001022 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 195099001023 HlyD family secretion protein; Region: HlyD_3; pfam13437 195099001024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 195099001025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 195099001026 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 195099001027 4Fe-4S binding domain; Region: Fer4_5; pfam12801 195099001028 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 195099001029 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 195099001030 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 195099001031 hypothetical protein; Provisional; Region: PRK04081 195099001032 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 195099001033 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 195099001034 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 195099001035 putative ligand binding site [chemical binding]; other site 195099001036 putative NAD binding site [chemical binding]; other site 195099001037 catalytic site [active] 195099001038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 195099001039 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 195099001040 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 195099001041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099001042 Walker A motif; other site 195099001043 ATP binding site [chemical binding]; other site 195099001044 Walker B motif; other site 195099001045 arginine finger; other site 195099001046 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 195099001047 TMAO/DMSO reductase; Reviewed; Region: PRK05363 195099001048 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 195099001049 Moco binding site; other site 195099001050 metal coordination site [ion binding]; other site 195099001051 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 195099001052 active site 195099001053 dimer interface [polypeptide binding]; other site 195099001054 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 195099001055 putative RNA binding site [nucleotide binding]; other site 195099001056 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 195099001057 homopentamer interface [polypeptide binding]; other site 195099001058 active site 195099001059 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 195099001060 EamA-like transporter family; Region: EamA; pfam00892 195099001061 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 195099001062 GTP-binding protein Der; Reviewed; Region: PRK00093 195099001063 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 195099001064 G1 box; other site 195099001065 GTP/Mg2+ binding site [chemical binding]; other site 195099001066 Switch I region; other site 195099001067 G2 box; other site 195099001068 Switch II region; other site 195099001069 G3 box; other site 195099001070 G4 box; other site 195099001071 G5 box; other site 195099001072 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 195099001073 GTP/Mg2+ binding site [chemical binding]; other site 195099001074 Switch I region; other site 195099001075 G2 box; other site 195099001076 G3 box; other site 195099001077 Switch II region; other site 195099001078 G4 box; other site 195099001079 G5 box; other site 195099001080 shikimate kinase; Reviewed; Region: aroK; PRK00131 195099001081 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 195099001082 ADP binding site [chemical binding]; other site 195099001083 magnesium binding site [ion binding]; other site 195099001084 putative shikimate binding site; other site 195099001085 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 195099001086 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 195099001087 active site 195099001088 HIGH motif; other site 195099001089 dimer interface [polypeptide binding]; other site 195099001090 KMSKS motif; other site 195099001091 seryl-tRNA synthetase; Provisional; Region: PRK05431 195099001092 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 195099001093 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 195099001094 dimer interface [polypeptide binding]; other site 195099001095 active site 195099001096 motif 1; other site 195099001097 motif 2; other site 195099001098 motif 3; other site 195099001099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 195099001100 binding surface 195099001101 TPR motif; other site 195099001102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 195099001103 TPR motif; other site 195099001104 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 195099001105 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 195099001106 domain interfaces; other site 195099001107 active site 195099001108 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 195099001109 Predicted dehydrogenase [General function prediction only]; Region: COG0579 195099001110 pantothenate kinase; Reviewed; Region: PRK13333 195099001111 PQQ-like domain; Region: PQQ_2; pfam13360 195099001112 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 195099001113 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 195099001114 Colicin V production protein; Region: Colicin_V; pfam02674 195099001115 ferric uptake regulator; Provisional; Region: fur; PRK09462 195099001116 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 195099001117 metal binding site 2 [ion binding]; metal-binding site 195099001118 putative DNA binding helix; other site 195099001119 metal binding site 1 [ion binding]; metal-binding site 195099001120 dimer interface [polypeptide binding]; other site 195099001121 structural Zn2+ binding site [ion binding]; other site 195099001122 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 195099001123 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 195099001124 dimer interface [polypeptide binding]; other site 195099001125 putative anticodon binding site; other site 195099001126 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 195099001127 motif 1; other site 195099001128 active site 195099001129 motif 2; other site 195099001130 motif 3; other site 195099001131 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 195099001132 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 195099001133 dimer interface [polypeptide binding]; other site 195099001134 active site 195099001135 glycine-pyridoxal phosphate binding site [chemical binding]; other site 195099001136 folate binding site [chemical binding]; other site 195099001137 Domain of unknown function (DUF1882); Region: DUF1882; pfam08966 195099001138 Sporulation related domain; Region: SPOR; pfam05036 195099001139 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 195099001140 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 195099001141 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 195099001142 shikimate binding site; other site 195099001143 NAD(P) binding site [chemical binding]; other site 195099001144 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 195099001145 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553 195099001146 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 195099001147 Iron-sulfur protein interface; other site 195099001148 proximal heme binding site [chemical binding]; other site 195099001149 distal heme binding site [chemical binding]; other site 195099001150 dimer interface [polypeptide binding]; other site 195099001151 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 195099001152 L-aspartate oxidase; Provisional; Region: PRK06175 195099001153 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 195099001154 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 195099001155 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 195099001156 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 195099001157 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 195099001158 Dynamin family; Region: Dynamin_N; pfam00350 195099001159 G1 box; other site 195099001160 GTP/Mg2+ binding site [chemical binding]; other site 195099001161 G2 box; other site 195099001162 Switch I region; other site 195099001163 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 195099001164 G3 box; other site 195099001165 Switch II region; other site 195099001166 GTP/Mg2+ binding site [chemical binding]; other site 195099001167 G4 box; other site 195099001168 G5 box; other site 195099001169 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 195099001170 Dynamin family; Region: Dynamin_N; pfam00350 195099001171 G1 box; other site 195099001172 GTP/Mg2+ binding site [chemical binding]; other site 195099001173 G2 box; other site 195099001174 Switch I region; other site 195099001175 G3 box; other site 195099001176 Switch II region; other site 195099001177 G4 box; other site 195099001178 G5 box; other site 195099001179 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 195099001180 Sel1-like repeats; Region: SEL1; smart00671 195099001181 Sel1 repeat; Region: Sel1; cl02723 195099001182 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 195099001183 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 195099001184 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 195099001185 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 195099001186 SprA-related family; Region: SprA-related; pfam12118 195099001187 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 195099001188 HIT family signature motif; other site 195099001189 catalytic residue [active] 195099001190 Uncharacterized conserved protein [Function unknown]; Region: COG2353 195099001191 Transposase; Region: HTH_Tnp_1; cl17663 195099001192 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 195099001193 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195099001194 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195099001195 ABC transporter; Region: ABC_tran_2; pfam12848 195099001196 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195099001197 S-layer like family, C-terminal region; Region: S_layer_C; pfam05124 195099001198 Uncharacterized conserved protein [Function unknown]; Region: COG1739 195099001199 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 195099001200 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 195099001201 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 195099001202 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 195099001203 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 195099001204 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 195099001205 Mg++ binding site [ion binding]; other site 195099001206 putative catalytic motif [active] 195099001207 putative substrate binding site [chemical binding]; other site 195099001208 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 195099001209 phosphoglyceromutase; Provisional; Region: PRK05434 195099001210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 195099001211 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 195099001212 NAD(P) binding site [chemical binding]; other site 195099001213 active site 195099001214 Uncharacterized conserved protein [Function unknown]; Region: COG5015 195099001215 L-aspartate oxidase; Provisional; Region: PRK06175 195099001216 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 195099001217 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 195099001218 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 195099001219 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 195099001220 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 195099001221 Cysteine-rich domain; Region: CCG; pfam02754 195099001222 Cysteine-rich domain; Region: CCG; pfam02754 195099001223 Putative transcription activator [Transcription]; Region: TenA; COG0819 195099001224 acyl carrier protein; Provisional; Region: acpP; PRK00982 195099001225 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 195099001226 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 195099001227 dimer interface [polypeptide binding]; other site 195099001228 active site 195099001229 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 195099001230 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 195099001231 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 195099001232 dimer interface [polypeptide binding]; other site 195099001233 ADP-ribose binding site [chemical binding]; other site 195099001234 active site 195099001235 nudix motif; other site 195099001236 metal binding site [ion binding]; metal-binding site 195099001237 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 195099001238 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 195099001239 dimer interface [polypeptide binding]; other site 195099001240 putative CheW interface [polypeptide binding]; other site 195099001241 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 195099001242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 195099001243 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 195099001244 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 195099001245 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 195099001246 substrate binding site [chemical binding]; other site 195099001247 hexamer interface [polypeptide binding]; other site 195099001248 metal binding site [ion binding]; metal-binding site 195099001249 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 195099001250 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 195099001251 active site 195099001252 catalytic site [active] 195099001253 substrate binding site [chemical binding]; other site 195099001254 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 195099001255 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 195099001256 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 195099001257 putative acyl-acceptor binding pocket; other site 195099001258 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 195099001259 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 195099001260 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195099001261 FeS/SAM binding site; other site 195099001262 TRAM domain; Region: TRAM; pfam01938 195099001263 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 195099001264 NusA N-terminal domain; Region: NusA_N; pfam08529 195099001265 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 195099001266 RNA binding site [nucleotide binding]; other site 195099001267 homodimer interface [polypeptide binding]; other site 195099001268 NusA-like KH domain; Region: KH_5; pfam13184 195099001269 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 195099001270 G-X-X-G motif; other site 195099001271 H+ Antiporter protein; Region: 2A0121; TIGR00900 195099001272 hypothetical protein; Provisional; Region: PRK08445 195099001273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195099001274 FeS/SAM binding site; other site 195099001275 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 195099001276 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 195099001277 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 195099001278 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 195099001279 generic binding surface II; other site 195099001280 ssDNA binding site; other site 195099001281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195099001282 ATP binding site [chemical binding]; other site 195099001283 putative Mg++ binding site [ion binding]; other site 195099001284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195099001285 nucleotide binding region [chemical binding]; other site 195099001286 ATP-binding site [chemical binding]; other site 195099001287 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 195099001288 apolar tunnel; other site 195099001289 heme binding site [chemical binding]; other site 195099001290 dimerization interface [polypeptide binding]; other site 195099001291 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 195099001292 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 195099001293 ligand binding site [chemical binding]; other site 195099001294 flexible hinge region; other site 195099001295 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 195099001296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099001297 dimer interface [polypeptide binding]; other site 195099001298 conserved gate region; other site 195099001299 putative PBP binding loops; other site 195099001300 ABC-ATPase subunit interface; other site 195099001301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099001302 dimer interface [polypeptide binding]; other site 195099001303 conserved gate region; other site 195099001304 putative PBP binding loops; other site 195099001305 ABC-ATPase subunit interface; other site 195099001306 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 195099001307 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 195099001308 Walker A/P-loop; other site 195099001309 ATP binding site [chemical binding]; other site 195099001310 Q-loop/lid; other site 195099001311 ABC transporter signature motif; other site 195099001312 Walker B; other site 195099001313 D-loop; other site 195099001314 H-loop/switch region; other site 195099001315 elongation factor Tu; Reviewed; Region: PRK00049 195099001316 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 195099001317 G1 box; other site 195099001318 GEF interaction site [polypeptide binding]; other site 195099001319 GTP/Mg2+ binding site [chemical binding]; other site 195099001320 Switch I region; other site 195099001321 G2 box; other site 195099001322 G3 box; other site 195099001323 Switch II region; other site 195099001324 G4 box; other site 195099001325 G5 box; other site 195099001326 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 195099001327 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 195099001328 Antibiotic Binding Site [chemical binding]; other site 195099001329 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 195099001330 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 195099001331 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 195099001332 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 195099001333 putative homodimer interface [polypeptide binding]; other site 195099001334 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 195099001335 heterodimer interface [polypeptide binding]; other site 195099001336 homodimer interface [polypeptide binding]; other site 195099001337 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 195099001338 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 195099001339 23S rRNA interface [nucleotide binding]; other site 195099001340 L7/L12 interface [polypeptide binding]; other site 195099001341 putative thiostrepton binding site; other site 195099001342 L25 interface [polypeptide binding]; other site 195099001343 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 195099001344 mRNA/rRNA interface [nucleotide binding]; other site 195099001345 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 195099001346 23S rRNA interface [nucleotide binding]; other site 195099001347 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 195099001348 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 195099001349 L11 interface [polypeptide binding]; other site 195099001350 putative EF-Tu interaction site [polypeptide binding]; other site 195099001351 putative EF-G interaction site [polypeptide binding]; other site 195099001352 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 195099001353 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 195099001354 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 195099001355 RPB11 interaction site [polypeptide binding]; other site 195099001356 RPB12 interaction site [polypeptide binding]; other site 195099001357 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 195099001358 RPB3 interaction site [polypeptide binding]; other site 195099001359 RPB1 interaction site [polypeptide binding]; other site 195099001360 RPB11 interaction site [polypeptide binding]; other site 195099001361 RPB10 interaction site [polypeptide binding]; other site 195099001362 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 195099001363 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 195099001364 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 195099001365 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 195099001366 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 195099001367 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 195099001368 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 195099001369 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 195099001370 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 195099001371 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 195099001372 DNA binding site [nucleotide binding] 195099001373 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 195099001374 Transcriptional regulator [Transcription]; Region: IclR; COG1414 195099001375 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 195099001376 putative DNA binding site [nucleotide binding]; other site 195099001377 putative Zn2+ binding site [ion binding]; other site 195099001378 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 195099001379 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 195099001380 inhibitor site; inhibition site 195099001381 active site 195099001382 dimer interface [polypeptide binding]; other site 195099001383 catalytic residue [active] 195099001384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099001385 putative substrate translocation pore; other site 195099001386 short chain dehydrogenase; Provisional; Region: PRK08628 195099001387 classical (c) SDRs; Region: SDR_c; cd05233 195099001388 NAD(P) binding site [chemical binding]; other site 195099001389 active site 195099001390 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 195099001391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099001392 putative substrate translocation pore; other site 195099001393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099001394 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 195099001395 Amidohydrolase; Region: Amidohydro_2; pfam04909 195099001396 Domain of unknown function (DUF718); Region: DUF718; cl01281 195099001397 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 195099001398 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 195099001399 NAD binding site [chemical binding]; other site 195099001400 catalytic residues [active] 195099001401 substrate binding site [chemical binding]; other site 195099001402 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 195099001403 S17 interaction site [polypeptide binding]; other site 195099001404 S8 interaction site; other site 195099001405 16S rRNA interaction site [nucleotide binding]; other site 195099001406 streptomycin interaction site [chemical binding]; other site 195099001407 23S rRNA interaction site [nucleotide binding]; other site 195099001408 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 195099001409 30S ribosomal protein S7; Validated; Region: PRK05302 195099001410 elongation factor G; Reviewed; Region: PRK00007 195099001411 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 195099001412 G1 box; other site 195099001413 putative GEF interaction site [polypeptide binding]; other site 195099001414 GTP/Mg2+ binding site [chemical binding]; other site 195099001415 Switch I region; other site 195099001416 G2 box; other site 195099001417 G3 box; other site 195099001418 Switch II region; other site 195099001419 G4 box; other site 195099001420 G5 box; other site 195099001421 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 195099001422 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 195099001423 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 195099001424 attL site 195099001425 lysogenic bacteriophage; targeted tRNA-Arg-4; CJE_PHAGE02 195099001426 integrase; Provisional; Region: PRK09692 195099001427 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 195099001428 active site 195099001429 DNA binding site [nucleotide binding] 195099001430 Int/Topo IB signature motif; other site 195099001431 Helix-turn-helix domain; Region: HTH_17; pfam12728 195099001432 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 195099001433 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 195099001434 AntA/AntB antirepressor; Region: AntA; pfam08346 195099001435 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 195099001436 DNA methylase; Region: N6_N4_Mtase; pfam01555 195099001437 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 195099001438 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 195099001439 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 195099001440 Helix-turn-helix domain; Region: HTH_39; pfam14090 195099001441 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 195099001442 Sel1-like repeats; Region: SEL1; smart00671 195099001443 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 195099001444 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 195099001445 active site 195099001446 substrate binding site [chemical binding]; other site 195099001447 Mg2+ binding site [ion binding]; other site 195099001448 Predicted transcriptional regulator [Transcription]; Region: COG2932 195099001449 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 195099001450 Catalytic site [active] 195099001451 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 195099001452 Endodeoxyribonuclease RusA; Region: RusA; cl01885 195099001453 Terminase-like family; Region: Terminase_6; pfam03237 195099001454 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 195099001455 crystallin beta/gamma motif-containing protein; Region: PHA00657 195099001456 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 195099001457 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 195099001458 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 195099001459 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 195099001460 attR site 195099001461 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 195099001462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195099001463 S-adenosylmethionine binding site [chemical binding]; other site 195099001464 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 195099001465 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 195099001466 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 195099001467 active site 195099001468 substrate (anthranilate) binding pocket [chemical binding]; other site 195099001469 product (indole) binding pocket [chemical binding]; other site 195099001470 ribulose/triose binding site [chemical binding]; other site 195099001471 phosphate binding site [ion binding]; other site 195099001472 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 195099001473 nucleotide binding site/active site [active] 195099001474 HIT family signature motif; other site 195099001475 catalytic residue [active] 195099001476 Predicted ATPase [General function prediction only]; Region: COG2603 195099001477 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 195099001478 active site residue [active] 195099001479 ferrochelatase; Reviewed; Region: hemH; PRK00035 195099001480 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 195099001481 C-terminal domain interface [polypeptide binding]; other site 195099001482 active site 195099001483 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 195099001484 active site 195099001485 N-terminal domain interface [polypeptide binding]; other site 195099001486 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 195099001487 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 195099001488 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 195099001489 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 195099001490 inhibitor-cofactor binding pocket; inhibition site 195099001491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099001492 catalytic residue [active] 195099001493 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 195099001494 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 195099001495 motif 1; other site 195099001496 active site 195099001497 motif 2; other site 195099001498 motif 3; other site 195099001499 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 195099001500 DHHA1 domain; Region: DHHA1; pfam02272 195099001501 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 195099001502 Maf-like protein; Region: Maf; pfam02545 195099001503 active site 195099001504 dimer interface [polypeptide binding]; other site 195099001505 Transglycosylase; Region: Transgly; pfam00912 195099001506 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 195099001507 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 195099001508 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 195099001509 Clp amino terminal domain; Region: Clp_N; pfam02861 195099001510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099001511 Walker A motif; other site 195099001512 ATP binding site [chemical binding]; other site 195099001513 Walker B motif; other site 195099001514 arginine finger; other site 195099001515 Protein of unknown function (DUF972); Region: DUF972; pfam06156 195099001516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099001517 Walker A motif; other site 195099001518 ATP binding site [chemical binding]; other site 195099001519 Walker B motif; other site 195099001520 arginine finger; other site 195099001521 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 195099001522 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 195099001523 putative homodimer interface [polypeptide binding]; other site 195099001524 putative homotetramer interface [polypeptide binding]; other site 195099001525 putative metal binding site [ion binding]; other site 195099001526 putative homodimer-homodimer interface [polypeptide binding]; other site 195099001527 putative allosteric switch controlling residues; other site 195099001528 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 195099001529 C-terminal peptidase (prc); Region: prc; TIGR00225 195099001530 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 195099001531 protein binding site [polypeptide binding]; other site 195099001532 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 195099001533 Catalytic dyad [active] 195099001534 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 195099001535 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 195099001536 ATP binding site [chemical binding]; other site 195099001537 active site 195099001538 substrate binding site [chemical binding]; other site 195099001539 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 195099001540 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 195099001541 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 195099001542 putative active site [active] 195099001543 catalytic triad [active] 195099001544 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 195099001545 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 195099001546 putative acyl-acceptor binding pocket; other site 195099001547 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 195099001548 heat shock protein 90; Provisional; Region: PRK05218 195099001549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195099001550 ATP binding site [chemical binding]; other site 195099001551 Mg2+ binding site [ion binding]; other site 195099001552 G-X-G motif; other site 195099001553 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 195099001554 active site residue [active] 195099001555 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 195099001556 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 195099001557 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 195099001558 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 195099001559 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 195099001560 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 195099001561 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK03907 195099001562 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 195099001563 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 195099001564 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 195099001565 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 195099001566 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 195099001567 YceG-like family; Region: YceG; pfam02618 195099001568 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 195099001569 dimerization interface [polypeptide binding]; other site 195099001570 Protein of unknown function; Region: DUF3971; pfam13116 195099001571 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 195099001572 AsmA-like C-terminal region; Region: AsmA_1; pfam13109 195099001573 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 195099001574 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 195099001575 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 195099001576 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 195099001577 NAD(P) binding site [chemical binding]; other site 195099001578 LDH/MDH dimer interface [polypeptide binding]; other site 195099001579 substrate binding site [chemical binding]; other site 195099001580 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 195099001581 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 195099001582 CoA-ligase; Region: Ligase_CoA; pfam00549 195099001583 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 195099001584 CoA binding domain; Region: CoA_binding; smart00881 195099001585 CoA-ligase; Region: Ligase_CoA; pfam00549 195099001586 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 195099001587 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 195099001588 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 195099001589 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 195099001590 dimer interface [polypeptide binding]; other site 195099001591 PYR/PP interface [polypeptide binding]; other site 195099001592 TPP binding site [chemical binding]; other site 195099001593 substrate binding site [chemical binding]; other site 195099001594 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 195099001595 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 195099001596 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 195099001597 TPP-binding site [chemical binding]; other site 195099001598 2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441 195099001599 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 195099001600 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 195099001601 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 195099001602 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 195099001603 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 195099001604 substrate binding pocket [chemical binding]; other site 195099001605 chain length determination region; other site 195099001606 substrate-Mg2+ binding site; other site 195099001607 catalytic residues [active] 195099001608 aspartate-rich region 1; other site 195099001609 active site lid residues [active] 195099001610 aspartate-rich region 2; other site 195099001611 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 195099001612 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 195099001613 tRNA; other site 195099001614 putative tRNA binding site [nucleotide binding]; other site 195099001615 putative NADP binding site [chemical binding]; other site 195099001616 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 195099001617 prolyl-tRNA synthetase; Provisional; Region: PRK09194 195099001618 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 195099001619 dimer interface [polypeptide binding]; other site 195099001620 motif 1; other site 195099001621 active site 195099001622 motif 2; other site 195099001623 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 195099001624 putative deacylase active site [active] 195099001625 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 195099001626 active site 195099001627 motif 3; other site 195099001628 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 195099001629 anticodon binding site; other site 195099001630 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 195099001631 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 195099001632 domain interfaces; other site 195099001633 active site 195099001634 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 195099001635 flagellar protein FlaG; Provisional; Region: PRK08452 195099001636 flagellar capping protein; Provisional; Region: PRK12765 195099001637 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 195099001638 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 195099001639 flagellar protein FliS; Validated; Region: fliS; PRK05685 195099001640 elongation factor P; Validated; Region: PRK00529 195099001641 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 195099001642 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 195099001643 RNA binding site [nucleotide binding]; other site 195099001644 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 195099001645 RNA binding site [nucleotide binding]; other site 195099001646 Predicted membrane protein [Function unknown]; Region: COG3819 195099001647 Predicted membrane protein [Function unknown]; Region: COG3817 195099001648 Protein of unknown function (DUF979); Region: DUF979; pfam06166 195099001649 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 195099001650 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 195099001651 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 195099001652 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 195099001653 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 195099001654 active site 195099001655 Predicted membrane protein [Function unknown]; Region: COG1289 195099001656 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 195099001657 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 195099001658 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 195099001659 putative catalytic cysteine [active] 195099001660 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 195099001661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 195099001662 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 195099001663 Protein of unknown function (DUF2860); Region: DUF2860; pfam11059 195099001664 replicative DNA helicase; Provisional; Region: PRK08506 195099001665 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 195099001666 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 195099001667 Walker A motif; other site 195099001668 ATP binding site [chemical binding]; other site 195099001669 Walker B motif; other site 195099001670 DNA binding loops [nucleotide binding] 195099001671 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 195099001672 G1 box; other site 195099001673 GTP/Mg2+ binding site [chemical binding]; other site 195099001674 G2 box; other site 195099001675 Switch I region; other site 195099001676 G3 box; other site 195099001677 Switch II region; other site 195099001678 G4 box; other site 195099001679 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 195099001680 Predicted transcriptional regulator [Transcription]; Region: COG2378 195099001681 HTH domain; Region: HTH_11; pfam08279 195099001682 WYL domain; Region: WYL; pfam13280 195099001683 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 195099001684 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 195099001685 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 195099001686 Uncharacterized conserved protein [Function unknown]; Region: COG1610 195099001687 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527 195099001688 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 195099001689 PYR/PP interface [polypeptide binding]; other site 195099001690 dimer interface [polypeptide binding]; other site 195099001691 TPP binding site [chemical binding]; other site 195099001692 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 195099001693 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 195099001694 TPP-binding site [chemical binding]; other site 195099001695 dimer interface [polypeptide binding]; other site 195099001696 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 195099001697 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 195099001698 putative valine binding site [chemical binding]; other site 195099001699 dimer interface [polypeptide binding]; other site 195099001700 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 195099001701 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 195099001702 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 195099001703 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 195099001704 trimer interface [polypeptide binding]; other site 195099001705 active site 195099001706 UDP-GlcNAc binding site [chemical binding]; other site 195099001707 lipid binding site [chemical binding]; lipid-binding site 195099001708 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 195099001709 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 195099001710 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 195099001711 sec-independent translocase; Provisional; Region: PRK04098 195099001712 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 195099001713 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 195099001714 putative active site [active] 195099001715 Ap4A binding site [chemical binding]; other site 195099001716 nudix motif; other site 195099001717 putative metal binding site [ion binding]; other site 195099001718 aspartate kinase; Reviewed; Region: PRK06635 195099001719 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 195099001720 putative nucleotide binding site [chemical binding]; other site 195099001721 putative catalytic residues [active] 195099001722 putative Mg ion binding site [ion binding]; other site 195099001723 putative aspartate binding site [chemical binding]; other site 195099001724 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 195099001725 putative allosteric regulatory site; other site 195099001726 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 195099001727 DNA replication regulator; Region: HobA; pfam12163 195099001728 DNA polymerase III subunit delta'; Validated; Region: PRK08485 195099001729 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 195099001730 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 195099001731 substrate binding pocket [chemical binding]; other site 195099001732 dimer interface [polypeptide binding]; other site 195099001733 inhibitor binding site; inhibition site 195099001734 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 195099001735 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 195099001736 nucleotide binding pocket [chemical binding]; other site 195099001737 K-X-D-G motif; other site 195099001738 catalytic site [active] 195099001739 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 195099001740 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 195099001741 Dimer interface [polypeptide binding]; other site 195099001742 BRCT sequence motif; other site 195099001743 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 195099001744 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 195099001745 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 195099001746 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 195099001747 active site 195099001748 nucleotide binding site [chemical binding]; other site 195099001749 HIGH motif; other site 195099001750 KMSKS motif; other site 195099001751 Riboflavin kinase; Region: Flavokinase; pfam01687 195099001752 Methyltransferase domain; Region: Methyltransf_31; pfam13847 195099001753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195099001754 S-adenosylmethionine binding site [chemical binding]; other site 195099001755 Predicted membrane protein [Function unknown]; Region: COG2860 195099001756 UPF0126 domain; Region: UPF0126; pfam03458 195099001757 UPF0126 domain; Region: UPF0126; pfam03458 195099001758 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 195099001759 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 195099001760 active site 195099001761 substrate binding site [chemical binding]; other site 195099001762 Mg2+ binding site [ion binding]; other site 195099001763 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 195099001764 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 195099001765 minor groove reading motif; other site 195099001766 helix-hairpin-helix signature motif; other site 195099001767 substrate binding pocket [chemical binding]; other site 195099001768 active site 195099001769 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 195099001770 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 195099001771 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 195099001772 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 195099001773 active site 195099001774 intersubunit interface [polypeptide binding]; other site 195099001775 zinc binding site [ion binding]; other site 195099001776 Na+ binding site [ion binding]; other site 195099001777 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 195099001778 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 195099001779 hypothetical protein; Validated; Region: PRK09039 195099001780 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 195099001781 ligand binding site [chemical binding]; other site 195099001782 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 195099001783 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 195099001784 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 195099001785 catalytic residue [active] 195099001786 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 195099001787 Na2 binding site [ion binding]; other site 195099001788 putative substrate binding site 1 [chemical binding]; other site 195099001789 Na binding site 1 [ion binding]; other site 195099001790 putative substrate binding site 2 [chemical binding]; other site 195099001791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 195099001792 MOSC domain; Region: MOSC; pfam03473 195099001793 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 195099001794 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 195099001795 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 195099001796 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 195099001797 DsbD alpha interface [polypeptide binding]; other site 195099001798 catalytic residues [active] 195099001799 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 195099001800 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 195099001801 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 195099001802 metal binding site [ion binding]; metal-binding site 195099001803 dimer interface [polypeptide binding]; other site 195099001804 macrolide transporter subunit MacA; Provisional; Region: PRK11578 195099001805 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 195099001806 HlyD family secretion protein; Region: HlyD_3; pfam13437 195099001807 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 195099001808 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 195099001809 Walker A/P-loop; other site 195099001810 ATP binding site [chemical binding]; other site 195099001811 Q-loop/lid; other site 195099001812 ABC transporter signature motif; other site 195099001813 Walker B; other site 195099001814 D-loop; other site 195099001815 H-loop/switch region; other site 195099001816 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 195099001817 FtsX-like permease family; Region: FtsX; pfam02687 195099001818 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 195099001819 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 195099001820 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 195099001821 active site 195099001822 oxyanion hole [active] 195099001823 catalytic triad [active] 195099001824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2845 195099001825 active site 195099001826 catalytic triad [active] 195099001827 oxyanion hole [active] 195099001828 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 195099001829 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 195099001830 Ferritin-like domain; Region: Ferritin; pfam00210 195099001831 ferroxidase diiron center [ion binding]; other site 195099001832 PBP superfamily domain; Region: PBP_like_2; cl17296 195099001833 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 195099001834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099001835 dimer interface [polypeptide binding]; other site 195099001836 conserved gate region; other site 195099001837 putative PBP binding loops; other site 195099001838 ABC-ATPase subunit interface; other site 195099001839 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 195099001840 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 195099001841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099001842 dimer interface [polypeptide binding]; other site 195099001843 conserved gate region; other site 195099001844 putative PBP binding loops; other site 195099001845 ABC-ATPase subunit interface; other site 195099001846 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14269 195099001847 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 195099001848 Walker A/P-loop; other site 195099001849 ATP binding site [chemical binding]; other site 195099001850 Q-loop/lid; other site 195099001851 ABC transporter signature motif; other site 195099001852 Walker B; other site 195099001853 D-loop; other site 195099001854 H-loop/switch region; other site 195099001855 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 195099001856 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 195099001857 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 195099001858 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 195099001859 Acylphosphatase; Region: Acylphosphatase; pfam00708 195099001860 HypF finger; Region: zf-HYPF; pfam07503 195099001861 HypF finger; Region: zf-HYPF; pfam07503 195099001862 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 195099001863 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 195099001864 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 195099001865 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 195099001866 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 195099001867 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 195099001868 dimerization interface [polypeptide binding]; other site 195099001869 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 195099001870 ATP binding site [chemical binding]; other site 195099001871 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 195099001872 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 195099001873 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 195099001874 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 195099001875 DNA methylase; Region: N6_N4_Mtase; pfam01555 195099001876 DNA methylase; Region: N6_N4_Mtase; pfam01555 195099001877 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195099001878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 195099001879 ATP binding site [chemical binding]; other site 195099001880 putative Mg++ binding site [ion binding]; other site 195099001881 DNA polymerase III subunit delta; Validated; Region: PRK08487 195099001882 Exoribonuclease R [Transcription]; Region: VacB; COG0557 195099001883 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 195099001884 RNB domain; Region: RNB; pfam00773 195099001885 ketol-acid reductoisomerase; Provisional; Region: PRK05479 195099001886 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 195099001887 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 195099001888 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 195099001889 NodB motif; other site 195099001890 putative active site [active] 195099001891 putative catalytic site [active] 195099001892 Zn binding site [ion binding]; other site 195099001893 DNA protecting protein DprA; Region: dprA; TIGR00732 195099001894 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 195099001895 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 195099001896 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 195099001897 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 195099001898 methionine sulfoxide reductase A; Provisional; Region: PRK14054 195099001899 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 195099001900 dimer interface [polypeptide binding]; other site 195099001901 substrate binding site [chemical binding]; other site 195099001902 metal binding sites [ion binding]; metal-binding site 195099001903 adenylate kinase; Reviewed; Region: adk; PRK00279 195099001904 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 195099001905 AMP-binding site [chemical binding]; other site 195099001906 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 195099001907 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 195099001908 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 195099001909 dimer interface [polypeptide binding]; other site 195099001910 anticodon binding site; other site 195099001911 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 195099001912 homodimer interface [polypeptide binding]; other site 195099001913 motif 1; other site 195099001914 active site 195099001915 motif 2; other site 195099001916 GAD domain; Region: GAD; pfam02938 195099001917 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 195099001918 active site 195099001919 motif 3; other site 195099001920 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: pnk; PRK14077 195099001921 ATP-NAD kinase; Region: NAD_kinase; pfam01513 195099001922 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 195099001923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195099001924 Walker A/P-loop; other site 195099001925 ATP binding site [chemical binding]; other site 195099001926 Q-loop/lid; other site 195099001927 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 195099001928 ABC transporter signature motif; other site 195099001929 Walker B; other site 195099001930 D-loop; other site 195099001931 H-loop/switch region; other site 195099001932 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 195099001933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195099001934 active site 195099001935 phosphorylation site [posttranslational modification] 195099001936 intermolecular recognition site; other site 195099001937 dimerization interface [polypeptide binding]; other site 195099001938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195099001939 active site 195099001940 phosphorylation site [posttranslational modification] 195099001941 intermolecular recognition site; other site 195099001942 dimerization interface [polypeptide binding]; other site 195099001943 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 195099001944 metal binding site [ion binding]; metal-binding site 195099001945 active site 195099001946 I-site; other site 195099001947 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 195099001948 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 195099001949 active site 195099001950 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 195099001951 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 195099001952 N-acetyl-D-glucosamine binding site [chemical binding]; other site 195099001953 catalytic residue [active] 195099001954 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 195099001955 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 195099001956 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 195099001957 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 195099001958 Sporulation related domain; Region: SPOR; pfam05036 195099001959 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 195099001960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195099001961 active site 195099001962 motif I; other site 195099001963 motif II; other site 195099001964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 195099001965 OstA-like protein; Region: OstA; pfam03968 195099001966 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 195099001967 G1 box; other site 195099001968 GTP/Mg2+ binding site [chemical binding]; other site 195099001969 Switch I region; other site 195099001970 G2 box; other site 195099001971 G3 box; other site 195099001972 Switch II region; other site 195099001973 G4 box; other site 195099001974 G5 box; other site 195099001975 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 195099001976 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 195099001977 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 195099001978 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 195099001979 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 195099001980 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 195099001981 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 195099001982 active site 195099001983 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 195099001984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099001985 putative substrate translocation pore; other site 195099001986 POT family; Region: PTR2; cl17359 195099001987 GTPase Era; Reviewed; Region: era; PRK00089 195099001988 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 195099001989 G1 box; other site 195099001990 GTP/Mg2+ binding site [chemical binding]; other site 195099001991 Switch I region; other site 195099001992 G2 box; other site 195099001993 Switch II region; other site 195099001994 G3 box; other site 195099001995 G4 box; other site 195099001996 G5 box; other site 195099001997 KH domain; Region: KH_2; pfam07650 195099001998 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 195099001999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099002000 Walker A motif; other site 195099002001 ATP binding site [chemical binding]; other site 195099002002 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 195099002003 Walker B motif; other site 195099002004 arginine finger; other site 195099002005 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 195099002006 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 195099002007 active site 195099002008 HslU subunit interaction site [polypeptide binding]; other site 195099002009 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 195099002010 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 195099002011 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 195099002012 argininosuccinate synthase; Provisional; Region: PRK13820 195099002013 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 195099002014 ANP binding site [chemical binding]; other site 195099002015 Substrate Binding Site II [chemical binding]; other site 195099002016 Substrate Binding Site I [chemical binding]; other site 195099002017 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis]; Region: COG1188 195099002018 RNA binding surface [nucleotide binding]; other site 195099002019 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 195099002020 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 195099002021 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 195099002022 Walker A/P-loop; other site 195099002023 ATP binding site [chemical binding]; other site 195099002024 Q-loop/lid; other site 195099002025 ABC transporter signature motif; other site 195099002026 Walker B; other site 195099002027 D-loop; other site 195099002028 H-loop/switch region; other site 195099002029 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 195099002030 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 195099002031 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 195099002032 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 195099002033 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 195099002034 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 195099002035 K+-transporting ATPase, c chain; Region: KdpC; cl00944 195099002036 excinuclease ABC subunit B; Provisional; Region: PRK05298 195099002037 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195099002038 ATP binding site [chemical binding]; other site 195099002039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195099002040 nucleotide binding region [chemical binding]; other site 195099002041 ATP-binding site [chemical binding]; other site 195099002042 Ultra-violet resistance protein B; Region: UvrB; pfam12344 195099002043 primosome assembly protein PriA; Validated; Region: PRK05580 195099002044 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195099002045 ATP binding site [chemical binding]; other site 195099002046 putative Mg++ binding site [ion binding]; other site 195099002047 helicase superfamily c-terminal domain; Region: HELICc; smart00490 195099002048 ATP-binding site [chemical binding]; other site 195099002049 Protein of unknown function (DUF2972); Region: DUF2972; pfam11186 195099002050 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 195099002051 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 195099002052 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 195099002053 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 195099002054 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 195099002055 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 195099002056 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 195099002057 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 195099002058 propionate/acetate kinase; Provisional; Region: PRK12379 195099002059 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 195099002060 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 195099002061 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 195099002062 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 195099002063 MraW methylase family; Region: Methyltransf_5; cl17771 195099002064 SurA N-terminal domain; Region: SurA_N_3; cl07813 195099002065 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 195099002066 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 195099002067 cell division protein FtsA; Region: ftsA; TIGR01174 195099002068 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 195099002069 nucleotide binding site [chemical binding]; other site 195099002070 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 195099002071 Cell division protein FtsA; Region: FtsA; pfam14450 195099002072 cell division protein FtsZ; Validated; Region: PRK09330 195099002073 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 195099002074 nucleotide binding site [chemical binding]; other site 195099002075 SulA interaction site; other site 195099002076 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 195099002077 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 195099002078 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 195099002079 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 195099002080 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 195099002081 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 195099002082 glutamine synthetase, type I; Region: GlnA; TIGR00653 195099002083 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 195099002084 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 195099002085 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 195099002086 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 195099002087 Peptidase family U32; Region: Peptidase_U32; pfam01136 195099002088 AIR carboxylase; Region: AIRC; smart01001 195099002089 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 195099002090 dimer interface [polypeptide binding]; other site 195099002091 motif 1; other site 195099002092 active site 195099002093 motif 2; other site 195099002094 motif 3; other site 195099002095 Uncharacterized conserved protein [Function unknown]; Region: COG0327 195099002096 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 195099002097 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 195099002098 Putative zinc ribbon domain; Region: DUF164; pfam02591 195099002099 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 195099002100 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 195099002101 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 195099002102 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 195099002103 active site 195099002104 signal recognition particle protein; Provisional; Region: PRK10867 195099002105 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 195099002106 P loop; other site 195099002107 GTP binding site [chemical binding]; other site 195099002108 Signal peptide binding domain; Region: SRP_SPB; pfam02978 195099002109 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 195099002110 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 195099002111 KH domain; Region: KH_4; pfam13083 195099002112 G-X-X-G motif; other site 195099002113 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 195099002114 RimM N-terminal domain; Region: RimM; pfam01782 195099002115 PRC-barrel domain; Region: PRC; pfam05239 195099002116 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 195099002117 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 195099002118 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 195099002119 active site 195099002120 homotetramer interface [polypeptide binding]; other site 195099002121 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 195099002122 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 195099002123 ArsC family; Region: ArsC; pfam03960 195099002124 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 195099002125 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 195099002126 active site 195099002127 PHP Thumb interface [polypeptide binding]; other site 195099002128 metal binding site [ion binding]; metal-binding site 195099002129 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 195099002130 generic binding surface I; other site 195099002131 generic binding surface II; other site 195099002132 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 195099002133 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 195099002134 catalytic residue [active] 195099002135 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 195099002136 flagellin; Provisional; Region: PRK12804 195099002137 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 195099002138 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 195099002139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 195099002140 Peptidase family M48; Region: Peptidase_M48; pfam01435 195099002141 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 195099002142 MPT binding site; other site 195099002143 trimer interface [polypeptide binding]; other site 195099002144 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 195099002145 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 195099002146 oligomer interface [polypeptide binding]; other site 195099002147 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 195099002148 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 195099002149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 195099002150 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 195099002151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 195099002152 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 195099002153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099002154 dimer interface [polypeptide binding]; other site 195099002155 conserved gate region; other site 195099002156 putative PBP binding loops; other site 195099002157 ABC-ATPase subunit interface; other site 195099002158 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 195099002159 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 195099002160 Walker A/P-loop; other site 195099002161 ATP binding site [chemical binding]; other site 195099002162 Q-loop/lid; other site 195099002163 ABC transporter signature motif; other site 195099002164 Walker B; other site 195099002165 D-loop; other site 195099002166 H-loop/switch region; other site 195099002167 TOBE domain; Region: TOBE_2; pfam08402 195099002168 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 195099002169 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 195099002170 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 195099002171 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 195099002172 substrate binding pocket [chemical binding]; other site 195099002173 membrane-bound complex binding site; other site 195099002174 hinge residues; other site 195099002175 haemagglutination activity domain; Region: Haemagg_act; smart00912 195099002176 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 195099002177 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 195099002178 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 195099002179 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 195099002180 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 195099002181 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 195099002182 N-terminal plug; other site 195099002183 ligand-binding site [chemical binding]; other site 195099002184 heat-inducible transcription repressor; Provisional; Region: PRK03911 195099002185 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 195099002186 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 195099002187 dimer interface [polypeptide binding]; other site 195099002188 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 195099002189 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 195099002190 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 195099002191 nucleotide binding site [chemical binding]; other site 195099002192 NEF interaction site [polypeptide binding]; other site 195099002193 SBD interface [polypeptide binding]; other site 195099002194 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 195099002195 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 195099002196 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 195099002197 aspartate aminotransferase; Provisional; Region: PRK05764 195099002198 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 195099002199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099002200 homodimer interface [polypeptide binding]; other site 195099002201 catalytic residue [active] 195099002202 serine O-acetyltransferase; Region: cysE; TIGR01172 195099002203 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 195099002204 trimer interface [polypeptide binding]; other site 195099002205 active site 195099002206 substrate binding site [chemical binding]; other site 195099002207 CoA binding site [chemical binding]; other site 195099002208 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 195099002209 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 195099002210 dimer interface [polypeptide binding]; other site 195099002211 active site 195099002212 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 195099002213 catalytic residues [active] 195099002214 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 195099002215 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 195099002216 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 195099002217 dimer interface [polypeptide binding]; other site 195099002218 motif 1; other site 195099002219 active site 195099002220 motif 2; other site 195099002221 motif 3; other site 195099002222 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 195099002223 anticodon binding site; other site 195099002224 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 195099002225 thymidylate kinase; Validated; Region: tmk; PRK00698 195099002226 TMP-binding site; other site 195099002227 ATP-binding site [chemical binding]; other site 195099002228 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 195099002229 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 195099002230 active site 195099002231 (T/H)XGH motif; other site 195099002232 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 195099002233 Flavoprotein; Region: Flavoprotein; pfam02441 195099002234 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515 195099002235 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 195099002236 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 195099002237 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 195099002238 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 195099002239 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 195099002240 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 195099002241 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 195099002242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099002243 ABC-ATPase subunit interface; other site 195099002244 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 195099002245 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 195099002246 Walker A/P-loop; other site 195099002247 ATP binding site [chemical binding]; other site 195099002248 Q-loop/lid; other site 195099002249 ABC transporter signature motif; other site 195099002250 Walker B; other site 195099002251 D-loop; other site 195099002252 H-loop/switch region; other site 195099002253 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 195099002254 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 195099002255 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 195099002256 active site 195099002257 HIGH motif; other site 195099002258 nucleotide binding site [chemical binding]; other site 195099002259 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 195099002260 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 195099002261 active site 195099002262 KMSKS motif; other site 195099002263 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 195099002264 tRNA binding surface [nucleotide binding]; other site 195099002265 anticodon binding site; other site 195099002266 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 195099002267 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 195099002268 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 195099002269 Part of AAA domain; Region: AAA_19; pfam13245 195099002270 Family description; Region: UvrD_C_2; pfam13538 195099002271 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 195099002272 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 195099002273 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 195099002274 dimer interface [polypeptide binding]; other site 195099002275 catalytic triad [active] 195099002276 peroxidatic and resolving cysteines [active] 195099002277 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 195099002278 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 195099002279 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 195099002280 molybdopterin cofactor binding site; other site 195099002281 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 195099002282 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 195099002283 molybdopterin cofactor binding site; other site 195099002284 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 195099002285 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 195099002286 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 195099002287 4Fe-4S binding domain; Region: Fer4_5; pfam12801 195099002288 4Fe-4S binding domain; Region: Fer4; cl02805 195099002289 Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043 195099002290 FOG: WD40 repeat [General function prediction only]; Region: COG2319 195099002291 Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062 195099002292 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 195099002293 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 195099002294 active site 195099002295 NTP binding site [chemical binding]; other site 195099002296 metal binding triad [ion binding]; metal-binding site 195099002297 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 195099002298 Formyltetrahydrofolate hydrolase [Nucleotide transport and metabolism]; Region: PurU; COG0788 195099002299 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 195099002300 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 195099002301 putative active site [active] 195099002302 putative substrate binding site [chemical binding]; other site 195099002303 putative cosubstrate binding site; other site 195099002304 catalytic site [active] 195099002305 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 195099002306 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 195099002307 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 195099002308 catalytic residue [active] 195099002309 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 195099002310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195099002311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195099002312 dimer interface [polypeptide binding]; other site 195099002313 phosphorylation site [posttranslational modification] 195099002314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195099002315 ATP binding site [chemical binding]; other site 195099002316 Mg2+ binding site [ion binding]; other site 195099002317 G-X-G motif; other site 195099002318 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 195099002319 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 195099002320 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 195099002321 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 195099002322 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 195099002323 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 195099002324 ATP-grasp domain; Region: ATP-grasp_4; cl17255 195099002325 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14601 195099002326 RuvA N terminal domain; Region: RuvA_N; pfam01330 195099002327 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 195099002328 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 195099002329 Protein of unknown function (DUF342); Region: DUF342; pfam03961 195099002330 integral membrane protein MviN; Region: mviN; TIGR01695 195099002331 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 195099002332 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 195099002333 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 195099002334 active site 195099002335 HIGH motif; other site 195099002336 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 195099002337 KMSKS motif; other site 195099002338 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 195099002339 tRNA binding surface [nucleotide binding]; other site 195099002340 anticodon binding site; other site 195099002341 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 195099002342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 195099002343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195099002344 Walker A/P-loop; other site 195099002345 ATP binding site [chemical binding]; other site 195099002346 Q-loop/lid; other site 195099002347 ABC transporter signature motif; other site 195099002348 Walker B; other site 195099002349 D-loop; other site 195099002350 H-loop/switch region; other site 195099002351 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 195099002352 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 195099002353 quinone interaction residues [chemical binding]; other site 195099002354 active site 195099002355 catalytic residues [active] 195099002356 FMN binding site [chemical binding]; other site 195099002357 substrate binding site [chemical binding]; other site 195099002358 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 195099002359 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 195099002360 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 195099002361 dihydrodipicolinate synthase; Region: dapA; TIGR00674 195099002362 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 195099002363 dimer interface [polypeptide binding]; other site 195099002364 active site 195099002365 catalytic residue [active] 195099002366 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 195099002367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 195099002368 NAD(P) binding site [chemical binding]; other site 195099002369 active site 195099002370 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 195099002371 NAD synthetase; Provisional; Region: PRK13980 195099002372 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 195099002373 homodimer interface [polypeptide binding]; other site 195099002374 NAD binding pocket [chemical binding]; other site 195099002375 ATP binding pocket [chemical binding]; other site 195099002376 Mg binding site [ion binding]; other site 195099002377 active-site loop [active] 195099002378 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 195099002379 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 195099002380 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 195099002381 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 195099002382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099002383 catalytic residue [active] 195099002384 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 195099002385 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 195099002386 Ligand binding site; other site 195099002387 oligomer interface; other site 195099002388 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 195099002389 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 195099002390 substrate binding pocket [chemical binding]; other site 195099002391 membrane-bound complex binding site; other site 195099002392 hinge residues; other site 195099002393 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 195099002394 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 195099002395 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 195099002396 Substrate binding site; other site 195099002397 Mg++ binding site; other site 195099002398 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 195099002399 active site 195099002400 substrate binding site [chemical binding]; other site 195099002401 CoA binding site [chemical binding]; other site 195099002402 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 195099002403 Flavoprotein; Region: Flavoprotein; pfam02441 195099002404 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 195099002405 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 195099002406 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 195099002407 catalytic residue [active] 195099002408 putative FPP diphosphate binding site; other site 195099002409 putative FPP binding hydrophobic cleft; other site 195099002410 dimer interface [polypeptide binding]; other site 195099002411 putative IPP diphosphate binding site; other site 195099002412 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 195099002413 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 195099002414 Predicted permeases [General function prediction only]; Region: COG0795 195099002415 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 195099002416 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 195099002417 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 195099002418 dimerization interface 3.5A [polypeptide binding]; other site 195099002419 active site 195099002420 threonine dehydratase; Provisional; Region: PRK08526 195099002421 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 195099002422 tetramer interface [polypeptide binding]; other site 195099002423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099002424 catalytic residue [active] 195099002425 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 195099002426 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 195099002427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 195099002428 tRNA (Uracil-5-)-methyltransferase; Region: tRNA_U5-meth_tr; pfam05958 195099002429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195099002430 S-adenosylmethionine binding site [chemical binding]; other site 195099002431 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 195099002432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 195099002433 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 195099002434 NAD(P) binding site [chemical binding]; other site 195099002435 active site 195099002436 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 195099002437 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 195099002438 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 195099002439 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 195099002440 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 195099002441 substrate binding site [chemical binding]; other site 195099002442 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 195099002443 substrate binding site [chemical binding]; other site 195099002444 ligand binding site [chemical binding]; other site 195099002445 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 195099002446 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 195099002447 DNA binding site [nucleotide binding] 195099002448 active site 195099002449 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 195099002450 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 195099002451 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 195099002452 active site 195099002453 HIGH motif; other site 195099002454 KMSKS motif; other site 195099002455 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 195099002456 tRNA binding surface [nucleotide binding]; other site 195099002457 anticodon binding site; other site 195099002458 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 195099002459 putative tRNA-binding site [nucleotide binding]; other site 195099002460 dimer interface [polypeptide binding]; other site 195099002461 Fructose-1,6-bisphosphatase [Carbohydrate transport and metabolism]; Region: Fbp; COG0158 195099002462 active site 195099002463 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 195099002464 Walker A motif; other site 195099002465 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 195099002466 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 195099002467 N-acetyl-D-glucosamine binding site [chemical binding]; other site 195099002468 catalytic residue [active] 195099002469 YGGT family; Region: YGGT; pfam02325 195099002470 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 195099002471 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 195099002472 active site 195099002473 HIGH motif; other site 195099002474 nucleotide binding site [chemical binding]; other site 195099002475 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 195099002476 active site 195099002477 KMSKS motif; other site 195099002478 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 195099002479 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 195099002480 putative active site [active] 195099002481 putative metal binding site [ion binding]; other site 195099002482 phosphatidylserine decarboxylase; Provisional; Region: PRK03934 195099002483 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 195099002484 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 195099002485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099002486 putative substrate translocation pore; other site 195099002487 Major Facilitator Superfamily; Region: MFS_1; pfam07690 195099002488 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 195099002489 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 195099002490 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 195099002491 inhibitor-cofactor binding pocket; inhibition site 195099002492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099002493 catalytic residue [active] 195099002494 ubiquitin-activating enzyme E1; Region: Ube1; TIGR01408 195099002495 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14166 195099002496 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 195099002497 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 195099002498 homodimer interface [polypeptide binding]; other site 195099002499 NADP binding site [chemical binding]; other site 195099002500 substrate binding site [chemical binding]; other site 195099002501 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 195099002502 Catalytic site [active] 195099002503 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 195099002504 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 195099002505 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 195099002506 dimer interface [polypeptide binding]; other site 195099002507 putative functional site; other site 195099002508 putative MPT binding site; other site 195099002509 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 195099002510 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 195099002511 hinge; other site 195099002512 active site 195099002513 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 195099002514 EamA-like transporter family; Region: EamA; pfam00892 195099002515 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 195099002516 Glutamine amidotransferase class-I; Region: GATase; pfam00117 195099002517 glutamine binding [chemical binding]; other site 195099002518 catalytic triad [active] 195099002519 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 195099002520 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 195099002521 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 195099002522 substrate-cofactor binding pocket; other site 195099002523 homodimer interface [polypeptide binding]; other site 195099002524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099002525 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 195099002526 catalytic residue [active] 195099002527 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 195099002528 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 195099002529 active site 195099002530 DNA binding site [nucleotide binding] 195099002531 Int/Topo IB signature motif; other site 195099002532 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 195099002533 catalytic residues [active] 195099002534 hinge region; other site 195099002535 alpha helical domain; other site 195099002536 putative disulfide oxidoreductase; Provisional; Region: PRK04307 195099002537 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 195099002538 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 195099002539 catalytic residues [active] 195099002540 hinge region; other site 195099002541 alpha helical domain; other site 195099002542 DHH family; Region: DHH; pfam01368 195099002543 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 195099002544 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 195099002545 FHIPEP family; Region: FHIPEP; pfam00771 195099002546 Rrf2 family protein; Region: rrf2_super; TIGR00738 195099002547 Transcriptional regulator; Region: Rrf2; pfam02082 195099002548 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 195099002549 16S/18S rRNA binding site [nucleotide binding]; other site 195099002550 S13e-L30e interaction site [polypeptide binding]; other site 195099002551 25S rRNA binding site [nucleotide binding]; other site 195099002552 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 195099002553 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 195099002554 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 195099002555 lagellar hook-associated protein FlgL; Provisional; Region: PRK14692 195099002556 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 195099002557 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 195099002558 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 195099002559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195099002560 Walker A/P-loop; other site 195099002561 ATP binding site [chemical binding]; other site 195099002562 Q-loop/lid; other site 195099002563 ABC transporter signature motif; other site 195099002564 Walker B; other site 195099002565 D-loop; other site 195099002566 H-loop/switch region; other site 195099002567 ABC transporter; Region: ABC_tran_2; pfam12848 195099002568 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195099002569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195099002570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195099002571 ATP binding site [chemical binding]; other site 195099002572 Mg2+ binding site [ion binding]; other site 195099002573 G-X-G motif; other site 195099002574 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 195099002575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195099002576 active site 195099002577 phosphorylation site [posttranslational modification] 195099002578 intermolecular recognition site; other site 195099002579 dimerization interface [polypeptide binding]; other site 195099002580 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195099002581 DNA binding site [nucleotide binding] 195099002582 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 195099002583 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 195099002584 ligand binding site [chemical binding]; other site 195099002585 NAD binding site [chemical binding]; other site 195099002586 dimerization interface [polypeptide binding]; other site 195099002587 catalytic site [active] 195099002588 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 195099002589 putative L-serine binding site [chemical binding]; other site 195099002590 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 195099002591 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 195099002592 RNA binding site [nucleotide binding]; other site 195099002593 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 195099002594 RNA binding site [nucleotide binding]; other site 195099002595 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 195099002596 RNA binding site [nucleotide binding]; other site 195099002597 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 195099002598 RNA binding site [nucleotide binding]; other site 195099002599 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 195099002600 RNA binding site [nucleotide binding]; other site 195099002601 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 195099002602 RNA binding site [nucleotide binding]; other site 195099002603 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 195099002604 LytB protein; Region: LYTB; pfam02401 195099002605 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 195099002606 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 195099002607 hinge; other site 195099002608 active site 195099002609 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 195099002610 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 195099002611 putative tRNA-binding site [nucleotide binding]; other site 195099002612 B3/4 domain; Region: B3_4; pfam03483 195099002613 tRNA synthetase B5 domain; Region: B5; smart00874 195099002614 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 195099002615 dimer interface [polypeptide binding]; other site 195099002616 motif 1; other site 195099002617 motif 3; other site 195099002618 motif 2; other site 195099002619 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 195099002620 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 195099002621 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 195099002622 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 195099002623 dimer interface [polypeptide binding]; other site 195099002624 motif 1; other site 195099002625 active site 195099002626 motif 2; other site 195099002627 motif 3; other site 195099002628 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 195099002629 nucleotide binding site/active site [active] 195099002630 HIT family signature motif; other site 195099002631 catalytic residue [active] 195099002632 DJ-1 family protein; Region: not_thiJ; TIGR01383 195099002633 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 195099002634 conserved cys residue [active] 195099002635 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 195099002636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099002637 dimer interface [polypeptide binding]; other site 195099002638 conserved gate region; other site 195099002639 putative PBP binding loops; other site 195099002640 ABC-ATPase subunit interface; other site 195099002641 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 195099002642 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 195099002643 Walker A/P-loop; other site 195099002644 ATP binding site [chemical binding]; other site 195099002645 Q-loop/lid; other site 195099002646 ABC transporter signature motif; other site 195099002647 Walker B; other site 195099002648 D-loop; other site 195099002649 H-loop/switch region; other site 195099002650 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 195099002651 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 195099002652 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 195099002653 alanine racemase; Reviewed; Region: alr; PRK00053 195099002654 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 195099002655 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 195099002656 catalytic residue [active] 195099002657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 195099002658 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 195099002659 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 195099002660 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 195099002661 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 195099002662 Cu(I) binding site [ion binding]; other site 195099002663 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 195099002664 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 195099002665 dimer interface [polypeptide binding]; other site 195099002666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099002667 catalytic residue [active] 195099002668 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 195099002669 IHF dimer interface [polypeptide binding]; other site 195099002670 IHF - DNA interface [nucleotide binding]; other site 195099002671 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 195099002672 Uncharacterized small protein [Function unknown]; Region: COG2879 195099002673 carbon starvation protein A; Provisional; Region: PRK15015 195099002674 Carbon starvation protein CstA; Region: CstA; pfam02554 195099002675 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 195099002676 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 195099002677 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 195099002678 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195099002679 active site 195099002680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099002681 dimer interface [polypeptide binding]; other site 195099002682 conserved gate region; other site 195099002683 putative PBP binding loops; other site 195099002684 ABC-ATPase subunit interface; other site 195099002685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099002686 dimer interface [polypeptide binding]; other site 195099002687 conserved gate region; other site 195099002688 putative PBP binding loops; other site 195099002689 ABC-ATPase subunit interface; other site 195099002690 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 195099002691 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 195099002692 substrate binding pocket [chemical binding]; other site 195099002693 membrane-bound complex binding site; other site 195099002694 hinge residues; other site 195099002695 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 195099002696 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 195099002697 Walker A/P-loop; other site 195099002698 ATP binding site [chemical binding]; other site 195099002699 Q-loop/lid; other site 195099002700 ABC transporter signature motif; other site 195099002701 Walker B; other site 195099002702 D-loop; other site 195099002703 H-loop/switch region; other site 195099002704 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 195099002705 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 195099002706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195099002707 S-adenosylmethionine binding site [chemical binding]; other site 195099002708 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 195099002709 CheB methylesterase; Region: CheB_methylest; pfam01339 195099002710 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 195099002711 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 195099002712 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 195099002713 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195099002714 active site 195099002715 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 195099002716 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 195099002717 multifunctional aminopeptidase A; Provisional; Region: PRK00913 195099002718 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 195099002719 interface (dimer of trimers) [polypeptide binding]; other site 195099002720 Substrate-binding/catalytic site; other site 195099002721 Zn-binding sites [ion binding]; other site 195099002722 GTP-binding protein YchF; Reviewed; Region: PRK09601 195099002723 YchF GTPase; Region: YchF; cd01900 195099002724 G1 box; other site 195099002725 GTP/Mg2+ binding site [chemical binding]; other site 195099002726 Switch I region; other site 195099002727 G2 box; other site 195099002728 Switch II region; other site 195099002729 G3 box; other site 195099002730 G4 box; other site 195099002731 G5 box; other site 195099002732 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 195099002733 argininosuccinate lyase; Provisional; Region: PRK00855 195099002734 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 195099002735 active sites [active] 195099002736 tetramer interface [polypeptide binding]; other site 195099002737 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 195099002738 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 195099002739 active site 195099002740 substrate-binding site [chemical binding]; other site 195099002741 metal-binding site [ion binding] 195099002742 ATP binding site [chemical binding]; other site 195099002743 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 195099002744 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 195099002745 active site 195099002746 catalytic residues [active] 195099002747 metal binding site [ion binding]; metal-binding site 195099002748 homodimer binding site [polypeptide binding]; other site 195099002749 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 195099002750 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 195099002751 carboxyltransferase (CT) interaction site; other site 195099002752 biotinylation site [posttranslational modification]; other site 195099002753 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 195099002754 Na2 binding site [ion binding]; other site 195099002755 putative substrate binding site 1 [chemical binding]; other site 195099002756 Na binding site 1 [ion binding]; other site 195099002757 putative substrate binding site 2 [chemical binding]; other site 195099002758 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 195099002759 Na2 binding site [ion binding]; other site 195099002760 putative substrate binding site 1 [chemical binding]; other site 195099002761 Na binding site 1 [ion binding]; other site 195099002762 putative substrate binding site 2 [chemical binding]; other site 195099002763 F0F1 ATP synthase subunit C; Validated; Region: PRK08482 195099002764 Predicted permeases [General function prediction only]; Region: COG0679 195099002765 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 195099002766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099002767 putative substrate translocation pore; other site 195099002768 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 195099002769 putative acyl-acceptor binding pocket; other site 195099002770 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 195099002771 acyl-activating enzyme (AAE) consensus motif; other site 195099002772 AMP binding site [chemical binding]; other site 195099002773 active site 195099002774 CoA binding site [chemical binding]; other site 195099002775 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 195099002776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099002777 dimer interface [polypeptide binding]; other site 195099002778 conserved gate region; other site 195099002779 putative PBP binding loops; other site 195099002780 ABC-ATPase subunit interface; other site 195099002781 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 195099002782 FtsX-like permease family; Region: FtsX; pfam02687 195099002783 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 195099002784 DEAD/DEAH box helicase; Region: DEAD; pfam00270 195099002785 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 195099002786 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195099002787 nucleotide binding region [chemical binding]; other site 195099002788 ATP-binding site [chemical binding]; other site 195099002789 SEC-C motif; Region: SEC-C; pfam02810 195099002790 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 195099002791 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 195099002792 PIF1-like helicase; Region: PIF1; pfam05970 195099002793 Helicase; Region: Herpes_Helicase; pfam02689 195099002794 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 195099002795 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 195099002796 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 195099002797 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 195099002798 NlpC/P60 family; Region: NLPC_P60; cl17555 195099002799 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 195099002800 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 195099002801 putative active site; other site 195099002802 catalytic triad [active] 195099002803 putative dimer interface [polypeptide binding]; other site 195099002804 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 195099002805 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 195099002806 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 195099002807 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 195099002808 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 195099002809 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 195099002810 dimer interface [polypeptide binding]; other site 195099002811 putative CheW interface [polypeptide binding]; other site 195099002812 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 195099002813 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 195099002814 purine monophosphate binding site [chemical binding]; other site 195099002815 dimer interface [polypeptide binding]; other site 195099002816 putative catalytic residues [active] 195099002817 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 195099002818 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 195099002819 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 195099002820 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 195099002821 putative metal binding site [ion binding]; other site 195099002822 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 195099002823 HSP70 interaction site [polypeptide binding]; other site 195099002824 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 195099002825 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 195099002826 dimerization interface [polypeptide binding]; other site 195099002827 ATP binding site [chemical binding]; other site 195099002828 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 195099002829 dimerization interface [polypeptide binding]; other site 195099002830 ATP binding site [chemical binding]; other site 195099002831 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 195099002832 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 195099002833 trmE is a tRNA modification GTPase; Region: trmE; cd04164 195099002834 G1 box; other site 195099002835 GTP/Mg2+ binding site [chemical binding]; other site 195099002836 Switch I region; other site 195099002837 G2 box; other site 195099002838 Switch II region; other site 195099002839 G3 box; other site 195099002840 G4 box; other site 195099002841 G5 box; other site 195099002842 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 195099002843 membrane protein insertase; Provisional; Region: PRK01318 195099002844 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 195099002845 Uncharacterized conserved protein [Function unknown]; Region: COG0759 195099002846 RNase P protein component [Translation, ribosomal structure and biogenesis]; Region: RnpA; COG0594 195099002847 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 195099002848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195099002849 Coenzyme A binding pocket [chemical binding]; other site 195099002850 Uracil-DNA glycosylase [DNA replication, recombination, and repair]; Region: COG1573 195099002851 ligand binding site [chemical binding]; other site 195099002852 active site 195099002853 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 195099002854 active site 195099002855 haemagglutination activity domain; Region: Haemagg_act; cl05436 195099002856 Methyltransferase domain; Region: Methyltransf_23; pfam13489 195099002857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195099002858 S-adenosylmethionine binding site [chemical binding]; other site 195099002859 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 195099002860 active site 1 [active] 195099002861 active site 2 [active] 195099002862 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 195099002863 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 195099002864 Catalytic site; other site 195099002865 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 195099002866 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 195099002867 metal binding site [ion binding]; metal-binding site 195099002868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099002869 metabolite-proton symporter; Region: 2A0106; TIGR00883 195099002870 putative substrate translocation pore; other site 195099002871 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 195099002872 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 195099002873 substrate binding pocket [chemical binding]; other site 195099002874 membrane-bound complex binding site; other site 195099002875 hinge residues; other site 195099002876 ADP-specific Phosphofructokinase/Glucokinase conserved region; Region: ADP_PFK_GK; cl14060 195099002877 Protein of unknown function (DUF328); Region: DUF328; cl01143 195099002878 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 195099002879 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 195099002880 metal binding site [ion binding]; metal-binding site 195099002881 putative dimer interface [polypeptide binding]; other site 195099002882 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 195099002883 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 195099002884 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 195099002885 Cysteine-rich domain; Region: CCG; pfam02754 195099002886 Cysteine-rich domain; Region: CCG; pfam02754 195099002887 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 195099002888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195099002889 FeS/SAM binding site; other site 195099002890 HemN C-terminal domain; Region: HemN_C; pfam06969 195099002891 Protein of unknown function (DUF2603); Region: DUF2603; pfam10788 195099002892 ornithine carbamoyltransferase; Provisional; Region: PRK00779 195099002893 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 195099002894 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 195099002895 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 195099002896 dimer interface [polypeptide binding]; other site 195099002897 active site 195099002898 Schiff base residues; other site 195099002899 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 195099002900 dimerization interface [polypeptide binding]; other site 195099002901 active site 195099002902 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 195099002903 16S rRNA (guanine(527)-N(7))-methyltransferase GidB; Region: gidB; TIGR00138 195099002904 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 195099002905 Transcriptional regulator [Transcription]; Region: LysR; COG0583 195099002906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 195099002907 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 195099002908 dimerization interface [polypeptide binding]; other site 195099002909 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 195099002910 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 195099002911 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 195099002912 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 195099002913 DNA binding residues [nucleotide binding] 195099002914 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 195099002915 catalytic core [active] 195099002916 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 195099002917 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 195099002918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099002919 Walker A motif; other site 195099002920 ATP binding site [chemical binding]; other site 195099002921 Walker B motif; other site 195099002922 arginine finger; other site 195099002923 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 195099002924 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 195099002925 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 195099002926 Mechanosensitive ion channel; Region: MS_channel; pfam00924 195099002927 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 195099002928 active site 195099002929 dimer interface [polypeptide binding]; other site 195099002930 metal binding site [ion binding]; metal-binding site 195099002931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 195099002932 TrkA-C domain; Region: TrkA_C; pfam02080 195099002933 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 195099002934 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 195099002935 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 195099002936 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 195099002937 Genomic Island/Integrate element. Targeted tRNA-Arg-3. Conjugative plasmid? attL/R=tcctcttgagcgcaccat 195099002938 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 195099002939 active site 195099002940 catalytic residues [active] 195099002941 DNA binding site [nucleotide binding] 195099002942 Int/Topo IB signature motif; other site 195099002943 Fic/DOC family; Region: Fic; cl00960 195099002944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 195099002945 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 195099002946 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 195099002947 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 195099002948 nucleophilic elbow; other site 195099002949 catalytic triad; other site 195099002950 LabA_like proteins; Region: LabA_like; cd06167 195099002951 Uncharacterized conserved protein [Function unknown]; Region: COG1432 195099002952 putative metal binding site [ion binding]; other site 195099002953 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 195099002954 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 195099002955 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 195099002956 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 195099002957 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 195099002958 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 195099002959 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 195099002960 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 195099002961 Walker A/P-loop; other site 195099002962 ATP binding site [chemical binding]; other site 195099002963 Q-loop/lid; other site 195099002964 ABC transporter signature motif; other site 195099002965 Walker B; other site 195099002966 D-loop; other site 195099002967 H-loop/switch region; other site 195099002968 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 195099002969 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 195099002970 Walker A/P-loop; other site 195099002971 ATP binding site [chemical binding]; other site 195099002972 Q-loop/lid; other site 195099002973 ABC transporter signature motif; other site 195099002974 Walker B; other site 195099002975 D-loop; other site 195099002976 H-loop/switch region; other site 195099002977 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 195099002978 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 195099002979 TM-ABC transporter signature motif; other site 195099002980 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 195099002981 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 195099002982 TM-ABC transporter signature motif; other site 195099002983 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 195099002984 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 195099002985 putative ligand binding site [chemical binding]; other site 195099002986 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 195099002987 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 195099002988 putative ligand binding site [chemical binding]; other site 195099002989 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 195099002990 Cytochrome c; Region: Cytochrom_C; cl11414 195099002991 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 195099002992 Predicted membrane protein [Function unknown]; Region: COG2862 195099002993 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 195099002994 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 195099002995 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 195099002996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195099002997 active site 195099002998 phosphorylation site [posttranslational modification] 195099002999 intermolecular recognition site; other site 195099003000 dimerization interface [polypeptide binding]; other site 195099003001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099003002 Walker A motif; other site 195099003003 ATP binding site [chemical binding]; other site 195099003004 Walker B motif; other site 195099003005 arginine finger; other site 195099003006 LPP20 lipoprotein; Region: LPP20; cl15824 195099003007 DNA gyrase subunit A; Validated; Region: PRK05560 195099003008 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 195099003009 CAP-like domain; other site 195099003010 active site 195099003011 primary dimer interface [polypeptide binding]; other site 195099003012 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 195099003013 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 195099003014 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 195099003015 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 195099003016 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 195099003017 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 195099003018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195099003019 active site 195099003020 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 195099003021 GTP-binding protein LepA; Provisional; Region: PRK05433 195099003022 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 195099003023 G1 box; other site 195099003024 putative GEF interaction site [polypeptide binding]; other site 195099003025 GTP/Mg2+ binding site [chemical binding]; other site 195099003026 Switch I region; other site 195099003027 G2 box; other site 195099003028 G3 box; other site 195099003029 Switch II region; other site 195099003030 G4 box; other site 195099003031 G5 box; other site 195099003032 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 195099003033 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 195099003034 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 195099003035 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 195099003036 HlyD family secretion protein; Region: HlyD_3; pfam13437 195099003037 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 195099003038 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 195099003039 HSP70 interaction site [polypeptide binding]; other site 195099003040 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 195099003041 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 195099003042 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 195099003043 acetyl-CoA carboxylase subunit A; Validated; Region: PRK08463 195099003044 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 195099003045 ATP-grasp domain; Region: ATP-grasp_4; cl17255 195099003046 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 195099003047 cell division protein FtsW; Region: ftsW; TIGR02614 195099003048 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 195099003049 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 195099003050 active site 195099003051 homodimer interface [polypeptide binding]; other site 195099003052 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 195099003053 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 195099003054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195099003055 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 195099003056 thiamine phosphate binding site [chemical binding]; other site 195099003057 active site 195099003058 pyrophosphate binding site [ion binding]; other site 195099003059 thiazole biosynthesis protein ThiH; Region: thiH; TIGR02351 195099003060 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195099003061 FeS/SAM binding site; other site 195099003062 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 195099003063 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 195099003064 ThiS interaction site; other site 195099003065 putative active site [active] 195099003066 tetramer interface [polypeptide binding]; other site 195099003067 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 195099003068 thiamine biosynthesis protein ThiF, family 2; Region: thiF_fam2; TIGR02354 195099003069 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 195099003070 putative ATP binding site [chemical binding]; other site 195099003071 putative substrate interface [chemical binding]; other site 195099003072 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 195099003073 thiS-thiF/thiG interaction site; other site 195099003074 succinyl-diaminopimelate desuccinylase, proteobacterial clade; Region: dapE_proteo; TIGR01246 195099003075 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 195099003076 metal binding site [ion binding]; metal-binding site 195099003077 dimer interface [polypeptide binding]; other site 195099003078 LysE type translocator; Region: LysE; pfam01810 195099003079 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 195099003080 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 195099003081 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 195099003082 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 195099003083 Methyltransferase domain; Region: Methyltransf_26; pfam13659 195099003084 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 195099003085 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 195099003086 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 195099003087 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 195099003088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195099003089 Walker A/P-loop; other site 195099003090 ATP binding site [chemical binding]; other site 195099003091 Q-loop/lid; other site 195099003092 ABC transporter signature motif; other site 195099003093 Walker B; other site 195099003094 D-loop; other site 195099003095 H-loop/switch region; other site 195099003096 Smr domain; Region: Smr; pfam01713 195099003097 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 195099003098 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 195099003099 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 195099003100 Predicted amidohydrolase [General function prediction only]; Region: COG0388 195099003101 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 195099003102 active site 195099003103 catalytic triad [active] 195099003104 dimer interface [polypeptide binding]; other site 195099003105 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 195099003106 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 195099003107 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 195099003108 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 195099003109 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 195099003110 active site 195099003111 indole-3-acetamide amidohydrolase; Region: PLN02722 195099003112 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 195099003113 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 195099003114 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 195099003115 active site 195099003116 HIGH motif; other site 195099003117 nucleotide binding site [chemical binding]; other site 195099003118 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 195099003119 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 195099003120 active site 195099003121 KMSKS motif; other site 195099003122 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 195099003123 tRNA binding surface [nucleotide binding]; other site 195099003124 anticodon binding site; other site 195099003125 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 195099003126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195099003127 Coenzyme A binding pocket [chemical binding]; other site 195099003128 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 195099003129 dimer interface [polypeptide binding]; other site 195099003130 FMN binding site [chemical binding]; other site 195099003131 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 195099003132 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 195099003133 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 195099003134 active site 195099003135 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 195099003136 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 195099003137 putative substrate binding region [chemical binding]; other site 195099003138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 195099003139 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 195099003140 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 195099003141 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 195099003142 dimer interface [polypeptide binding]; other site 195099003143 ssDNA binding site [nucleotide binding]; other site 195099003144 tetramer (dimer of dimers) interface [polypeptide binding]; other site 195099003145 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 195099003146 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 195099003147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099003148 Walker A motif; other site 195099003149 ATP binding site [chemical binding]; other site 195099003150 Walker B motif; other site 195099003151 arginine finger; other site 195099003152 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 195099003153 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 195099003154 flagellar assembly protein FliW; Provisional; Region: PRK13282 195099003155 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 195099003156 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 195099003157 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 195099003158 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 195099003159 active site 195099003160 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 195099003161 thiamine phosphate binding site [chemical binding]; other site 195099003162 active site 195099003163 pyrophosphate binding site [ion binding]; other site 195099003164 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 195099003165 substrate binding site [chemical binding]; other site 195099003166 dimer interface [polypeptide binding]; other site 195099003167 ATP binding site [chemical binding]; other site 195099003168 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 195099003169 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 195099003170 minor groove reading motif; other site 195099003171 helix-hairpin-helix signature motif; other site 195099003172 active site 195099003173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099003174 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 195099003175 Walker A motif; other site 195099003176 ATP binding site [chemical binding]; other site 195099003177 Walker B motif; other site 195099003178 arginine finger; other site 195099003179 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 195099003180 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 195099003181 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195099003182 ATP binding site [chemical binding]; other site 195099003183 putative Mg++ binding site [ion binding]; other site 195099003184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195099003185 nucleotide binding region [chemical binding]; other site 195099003186 ATP-binding site [chemical binding]; other site 195099003187 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 195099003188 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 195099003189 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 195099003190 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 195099003191 Peptidase family M23; Region: Peptidase_M23; pfam01551 195099003192 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 195099003193 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 195099003194 Lipopolysaccharide-assembly; Region: LptE; pfam04390 195099003195 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 195099003196 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 195099003197 HIGH motif; other site 195099003198 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 195099003199 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 195099003200 active site 195099003201 KMSKS motif; other site 195099003202 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 195099003203 tRNA binding surface [nucleotide binding]; other site 195099003204 anticodon binding site; other site 195099003205 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 195099003206 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 195099003207 Protein export membrane protein; Region: SecD_SecF; pfam02355 195099003208 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 195099003209 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 195099003210 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 195099003211 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 195099003212 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 195099003213 active site 195099003214 catalytic triad [active] 195099003215 dimer interface [polypeptide binding]; other site 195099003216 S-adenosylmethionine synthetase; Validated; Region: PRK05250 195099003217 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 195099003218 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 195099003219 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 195099003220 Na+/serine symporter [Amino acid transport and metabolism]; Region: SstT; COG3633 195099003221 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 195099003222 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 195099003223 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 195099003224 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 195099003225 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 195099003226 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 195099003227 active site 195099003228 Zn binding site [ion binding]; other site 195099003229 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 195099003230 Part of AAA domain; Region: AAA_19; pfam13245 195099003231 Family description; Region: UvrD_C_2; pfam13538 195099003232 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04099 195099003233 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 195099003234 active site 195099003235 RNA-binding global regulator CsrA [Signal transduction mechanisms]; Region: CsrA; COG1551 195099003236 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 195099003237 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 195099003238 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 195099003239 SmpB-tmRNA interface; other site 195099003240 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 195099003241 catalytic residues [active] 195099003242 Uncharacterized conserved protein [Function unknown]; Region: COG2127 195099003243 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 195099003244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099003245 Walker A motif; other site 195099003246 ATP binding site [chemical binding]; other site 195099003247 Walker B motif; other site 195099003248 arginine finger; other site 195099003249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099003250 Walker A motif; other site 195099003251 ATP binding site [chemical binding]; other site 195099003252 Walker B motif; other site 195099003253 arginine finger; other site 195099003254 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 195099003255 Leu/Phe-tRNA-protein transferase [Posttranslational modification, protein turnover, chaperones]; Region: Aat; COG2360 195099003256 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 195099003257 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 195099003258 putative active site [active] 195099003259 heme pocket [chemical binding]; other site 195099003260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 195099003261 putative active site [active] 195099003262 heme pocket [chemical binding]; other site 195099003263 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 195099003264 dimer interface [polypeptide binding]; other site 195099003265 putative CheW interface [polypeptide binding]; other site 195099003266 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 195099003267 methionine sulfoxide reductase B; Provisional; Region: PRK05508 195099003268 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 195099003269 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 195099003270 dinuclear metal binding motif [ion binding]; other site 195099003271 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 195099003272 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 195099003273 Phosphatidylserine decarboxylase [Lipid metabolism]; Region: Psd; COG0688 195099003274 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 195099003275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099003276 Walker A motif; other site 195099003277 ATP binding site [chemical binding]; other site 195099003278 Walker B motif; other site 195099003279 arginine finger; other site 195099003280 Peptidase family M41; Region: Peptidase_M41; pfam01434 195099003281 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 195099003282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195099003283 S-adenosylmethionine binding site [chemical binding]; other site 195099003284 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 195099003285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195099003286 active site 195099003287 phosphorylation site [posttranslational modification] 195099003288 intermolecular recognition site; other site 195099003289 dimerization interface [polypeptide binding]; other site 195099003290 Cache domain; Region: Cache_1; pfam02743 195099003291 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 195099003292 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 195099003293 NAD(P) binding site [chemical binding]; other site 195099003294 homodimer interface [polypeptide binding]; other site 195099003295 substrate binding site [chemical binding]; other site 195099003296 active site 195099003297 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 195099003298 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 195099003299 inhibitor-cofactor binding pocket; inhibition site 195099003300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099003301 catalytic residue [active] 195099003302 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 195099003303 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 195099003304 putative trimer interface [polypeptide binding]; other site 195099003305 putative CoA binding site [chemical binding]; other site 195099003306 Bacterial sugar transferase; Region: Bac_transf; pfam02397 195099003307 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 195099003308 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 195099003309 putative ADP-binding pocket [chemical binding]; other site 195099003310 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 195099003311 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 195099003312 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 195099003313 putative ADP-binding pocket [chemical binding]; other site 195099003314 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 195099003315 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 195099003316 active site 195099003317 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 195099003318 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 195099003319 putative ADP-binding pocket [chemical binding]; other site 195099003320 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 195099003321 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 195099003322 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195099003323 Walker A/P-loop; other site 195099003324 ATP binding site [chemical binding]; other site 195099003325 Q-loop/lid; other site 195099003326 ABC transporter signature motif; other site 195099003327 Walker B; other site 195099003328 D-loop; other site 195099003329 H-loop/switch region; other site 195099003330 UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179 195099003331 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 195099003332 NAD binding site [chemical binding]; other site 195099003333 homodimer interface [polypeptide binding]; other site 195099003334 active site 195099003335 substrate binding site [chemical binding]; other site 195099003336 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 195099003337 active site 195099003338 catalytic site [active] 195099003339 substrate binding site [chemical binding]; other site 195099003340 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 195099003341 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 195099003342 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 195099003343 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 195099003344 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 195099003345 putative active site [active] 195099003346 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 195099003347 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 195099003348 putative acyl-acceptor binding pocket; other site 195099003349 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 195099003350 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 195099003351 putative metal binding site; other site 195099003352 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 195099003353 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 195099003354 Substrate binding site; other site 195099003355 metal-binding site 195099003356 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 195099003357 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 195099003358 active site 195099003359 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 195099003360 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 195099003361 active site 195099003362 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 195099003363 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 195099003364 active site 195099003365 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 195099003366 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 195099003367 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 195099003368 active site 195099003369 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 195099003370 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 195099003371 putative active site [active] 195099003372 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 195099003373 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 195099003374 dimer interface [polypeptide binding]; other site 195099003375 active site 195099003376 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 195099003377 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 195099003378 putative ribose interaction site [chemical binding]; other site 195099003379 putative ADP binding site [chemical binding]; other site 195099003380 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 195099003381 active site 195099003382 nucleotide binding site [chemical binding]; other site 195099003383 HIGH motif; other site 195099003384 KMSKS motif; other site 195099003385 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 195099003386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 195099003387 NAD(P) binding site [chemical binding]; other site 195099003388 active site 195099003389 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 195099003390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195099003391 active site 195099003392 motif I; other site 195099003393 motif II; other site 195099003394 Cytochrome c553 [Energy production and conversion]; Region: COG2863 195099003395 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 195099003396 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 195099003397 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 195099003398 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 195099003399 metal-binding site [ion binding] 195099003400 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 195099003401 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195099003402 motif II; other site 195099003403 transcription termination factor Rho; Provisional; Region: rho; PRK09376 195099003404 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 195099003405 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 195099003406 RNA binding site [nucleotide binding]; other site 195099003407 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 195099003408 multimer interface [polypeptide binding]; other site 195099003409 Walker A motif; other site 195099003410 ATP binding site [chemical binding]; other site 195099003411 Walker B motif; other site 195099003412 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08451 195099003413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099003414 Walker A motif; other site 195099003415 ATP binding site [chemical binding]; other site 195099003416 DNA polymerase III subunit delta'; Validated; Region: PRK08485 195099003417 Walker B motif; other site 195099003418 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 195099003419 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 195099003420 metal-binding site [ion binding] 195099003421 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 195099003422 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 195099003423 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 195099003424 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 195099003425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 195099003426 Uncharacterized conserved protein [Function unknown]; Region: COG3610 195099003427 Uncharacterized conserved protein [Function unknown]; Region: COG2966 195099003428 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 195099003429 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 195099003430 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 195099003431 NAD binding site [chemical binding]; other site 195099003432 dimer interface [polypeptide binding]; other site 195099003433 tetramer (dimer of dimers) interface [polypeptide binding]; other site 195099003434 substrate binding site [chemical binding]; other site 195099003435 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 195099003436 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 195099003437 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 195099003438 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 195099003439 active site 195099003440 hypothetical protein; Provisional; Region: PRK12378 195099003441 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 195099003442 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 195099003443 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 195099003444 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 195099003445 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 195099003446 active site 195099003447 HIGH motif; other site 195099003448 KMSK motif region; other site 195099003449 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 195099003450 tRNA binding surface [nucleotide binding]; other site 195099003451 anticodon binding site; other site 195099003452 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 195099003453 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 195099003454 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 195099003455 catalytic site [active] 195099003456 G-X2-G-X-G-K; other site 195099003457 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 195099003458 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 195099003459 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 195099003460 Walker A/P-loop; other site 195099003461 ATP binding site [chemical binding]; other site 195099003462 Q-loop/lid; other site 195099003463 ABC transporter signature motif; other site 195099003464 Walker B; other site 195099003465 D-loop; other site 195099003466 H-loop/switch region; other site 195099003467 elongation factor Ts; Provisional; Region: tsf; PRK09377 195099003468 UBA/TS-N domain; Region: UBA; pfam00627 195099003469 Elongation factor TS; Region: EF_TS; pfam00889 195099003470 Elongation factor TS; Region: EF_TS; pfam00889 195099003471 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 195099003472 rRNA interaction site [nucleotide binding]; other site 195099003473 S8 interaction site; other site 195099003474 putative laminin-1 binding site; other site 195099003475 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 195099003476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195099003477 S-adenosylmethionine binding site [chemical binding]; other site 195099003478 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 195099003479 Cytochrome c; Region: Cytochrom_C; pfam00034 195099003480 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 195099003481 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 195099003482 intrachain domain interface; other site 195099003483 interchain domain interface [polypeptide binding]; other site 195099003484 heme bH binding site [chemical binding]; other site 195099003485 Qi binding site; other site 195099003486 heme bL binding site [chemical binding]; other site 195099003487 Qo binding site; other site 195099003488 interchain domain interface [polypeptide binding]; other site 195099003489 intrachain domain interface; other site 195099003490 Qi binding site; other site 195099003491 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 195099003492 Qo binding site; other site 195099003493 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 195099003494 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 195099003495 [2Fe-2S] cluster binding site [ion binding]; other site 195099003496 arsenical pump membrane protein; Provisional; Region: PRK15445 195099003497 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 195099003498 transmembrane helices; other site 195099003499 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 195099003500 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 195099003501 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 195099003502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 195099003503 PAS domain; Region: PAS_9; pfam13426 195099003504 putative active site [active] 195099003505 heme pocket [chemical binding]; other site 195099003506 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 195099003507 dimer interface [polypeptide binding]; other site 195099003508 putative CheW interface [polypeptide binding]; other site 195099003509 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 195099003510 PAS domain; Region: PAS_9; pfam13426 195099003511 putative active site [active] 195099003512 heme pocket [chemical binding]; other site 195099003513 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 195099003514 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 195099003515 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 195099003516 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 195099003517 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 195099003518 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 195099003519 dihydroorotase; Provisional; Region: PRK08417 195099003520 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 195099003521 active site 195099003522 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 195099003523 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 195099003524 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 195099003525 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 195099003526 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 195099003527 GatB domain; Region: GatB_Yqey; smart00845 195099003528 S-ribosylhomocysteinase; Provisional; Region: PRK02260 195099003529 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 195099003530 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 195099003531 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 195099003532 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 195099003533 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 195099003534 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 195099003535 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 195099003536 THF binding site; other site 195099003537 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 195099003538 substrate binding site [chemical binding]; other site 195099003539 THF binding site; other site 195099003540 zinc-binding site [ion binding]; other site 195099003541 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 195099003542 FAD binding site [chemical binding]; other site 195099003543 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 195099003544 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 195099003545 DNA repair protein RadA; Provisional; Region: PRK11823 195099003546 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 195099003547 Walker A motif; other site 195099003548 ATP binding site [chemical binding]; other site 195099003549 Walker B motif; other site 195099003550 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 195099003551 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 195099003552 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 195099003553 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 195099003554 P loop; other site 195099003555 GTP binding site [chemical binding]; other site 195099003556 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 195099003557 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 195099003558 catalytic residues [active] 195099003559 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 195099003560 phosphodiesterase; Provisional; Region: PRK12704 195099003561 KH domain; Region: KH_1; pfam00013 195099003562 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 195099003563 Zn2+ binding site [ion binding]; other site 195099003564 Mg2+ binding site [ion binding]; other site 195099003565 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 195099003566 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 195099003567 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 195099003568 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 195099003569 FAD binding domain; Region: FAD_binding_4; pfam01565 195099003570 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 195099003571 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 195099003572 Peptidase family M23; Region: Peptidase_M23; pfam01551 195099003573 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 195099003574 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 195099003575 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 195099003576 Lumazine binding domain; Region: Lum_binding; pfam00677 195099003577 Lumazine binding domain; Region: Lum_binding; pfam00677 195099003578 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 195099003579 oligomerisation interface [polypeptide binding]; other site 195099003580 mobile loop; other site 195099003581 roof hairpin; other site 195099003582 chaperonin GroL; Region: GroEL; TIGR02348 195099003583 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 195099003584 ring oligomerisation interface [polypeptide binding]; other site 195099003585 ATP/Mg binding site [chemical binding]; other site 195099003586 stacking interactions; other site 195099003587 hinge regions; other site 195099003588 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195099003589 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195099003590 dimer interface [polypeptide binding]; other site 195099003591 phosphorylation site [posttranslational modification] 195099003592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195099003593 ATP binding site [chemical binding]; other site 195099003594 Mg2+ binding site [ion binding]; other site 195099003595 G-X-G motif; other site 195099003596 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195099003597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195099003598 active site 195099003599 phosphorylation site [posttranslational modification] 195099003600 intermolecular recognition site; other site 195099003601 dimerization interface [polypeptide binding]; other site 195099003602 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 195099003603 DNA binding site [nucleotide binding] 195099003604 Hemerythrin; Region: Hemerythrin; cd12107 195099003605 Fe binding site [ion binding]; other site 195099003606 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 195099003607 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195099003608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195099003609 dimer interface [polypeptide binding]; other site 195099003610 phosphorylation site [posttranslational modification] 195099003611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195099003612 ATP binding site [chemical binding]; other site 195099003613 Mg2+ binding site [ion binding]; other site 195099003614 G-X-G motif; other site 195099003615 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195099003616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195099003617 active site 195099003618 phosphorylation site [posttranslational modification] 195099003619 intermolecular recognition site; other site 195099003620 dimerization interface [polypeptide binding]; other site 195099003621 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195099003622 DNA binding site [nucleotide binding] 195099003623 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 195099003624 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 195099003625 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 195099003626 protein binding site [polypeptide binding]; other site 195099003627 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 195099003628 protein binding site [polypeptide binding]; other site 195099003629 chaperone protein DnaJ; Provisional; Region: PRK14299 195099003630 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 195099003631 HSP70 interaction site [polypeptide binding]; other site 195099003632 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 195099003633 substrate binding site [polypeptide binding]; other site 195099003634 dimer interface [polypeptide binding]; other site 195099003635 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 195099003636 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 195099003637 DNA binding residues [nucleotide binding] 195099003638 putative dimer interface [polypeptide binding]; other site 195099003639 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 195099003640 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 195099003641 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 195099003642 TrkA-N domain; Region: TrkA_N; pfam02254 195099003643 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 195099003644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195099003645 motif II; other site 195099003646 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 195099003647 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 195099003648 Peptidase family M23; Region: Peptidase_M23; pfam01551 195099003649 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 195099003650 exopolyphosphatase; Region: exo_poly_only; TIGR03706 195099003651 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 195099003652 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 195099003653 active site 195099003654 hydrophilic channel; other site 195099003655 dimerization interface [polypeptide binding]; other site 195099003656 catalytic residues [active] 195099003657 active site lid [active] 195099003658 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946 195099003659 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 195099003660 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 195099003661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099003662 putative substrate translocation pore; other site 195099003663 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 195099003664 substrate binding site [chemical binding]; other site 195099003665 active site 195099003666 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 195099003667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195099003668 FeS/SAM binding site; other site 195099003669 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 195099003670 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 195099003671 GIY-YIG motif/motif A; other site 195099003672 active site 195099003673 catalytic site [active] 195099003674 putative DNA binding site [nucleotide binding]; other site 195099003675 metal binding site [ion binding]; metal-binding site 195099003676 UvrB/uvrC motif; Region: UVR; pfam02151 195099003677 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 195099003678 GMP synthase; Reviewed; Region: guaA; PRK00074 195099003679 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 195099003680 AMP/PPi binding site [chemical binding]; other site 195099003681 candidate oxyanion hole; other site 195099003682 catalytic triad [active] 195099003683 potential glutamine specificity residues [chemical binding]; other site 195099003684 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 195099003685 ATP Binding subdomain [chemical binding]; other site 195099003686 Ligand Binding sites [chemical binding]; other site 195099003687 Dimerization subdomain; other site 195099003688 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 195099003689 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 195099003690 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 195099003691 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 195099003692 Predicted membrane protein/domain [Function unknown]; Region: COG1714 195099003693 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 195099003694 Organic solvent tolerance protein; Region: OstA_C; pfam04453 195099003695 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 195099003696 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 195099003697 oligomer interface [polypeptide binding]; other site 195099003698 RNA binding site [nucleotide binding]; other site 195099003699 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 195099003700 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 195099003701 RNase E interface [polypeptide binding]; other site 195099003702 trimer interface [polypeptide binding]; other site 195099003703 active site 195099003704 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 195099003705 putative nucleic acid binding region [nucleotide binding]; other site 195099003706 G-X-X-G motif; other site 195099003707 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 195099003708 RNA binding site [nucleotide binding]; other site 195099003709 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 195099003710 putative active site [active] 195099003711 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 195099003712 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 195099003713 Low molecular weight phosphatase family; Region: LMWPc; cd00115 195099003714 active site 195099003715 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 195099003716 chaperone protein DnaJ; Provisional; Region: PRK10767 195099003717 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 195099003718 HSP70 interaction site [polypeptide binding]; other site 195099003719 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 195099003720 substrate binding site [polypeptide binding]; other site 195099003721 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 195099003722 Zn binding sites [ion binding]; other site 195099003723 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 195099003724 dimer interface [polypeptide binding]; other site 195099003725 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195099003726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195099003727 active site 195099003728 phosphorylation site [posttranslational modification] 195099003729 intermolecular recognition site; other site 195099003730 dimerization interface [polypeptide binding]; other site 195099003731 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195099003732 DNA binding site [nucleotide binding] 195099003733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195099003734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195099003735 dimer interface [polypeptide binding]; other site 195099003736 phosphorylation site [posttranslational modification] 195099003737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195099003738 ATP binding site [chemical binding]; other site 195099003739 Mg2+ binding site [ion binding]; other site 195099003740 G-X-G motif; other site 195099003741 recombination protein RecR; Reviewed; Region: recR; PRK00076 195099003742 RecR protein; Region: RecR; pfam02132 195099003743 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 195099003744 active site 195099003745 metal binding site [ion binding]; metal-binding site 195099003746 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 195099003747 putative substrate-binding site; other site 195099003748 nickel binding site [ion binding]; other site 195099003749 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 195099003750 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 195099003751 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 195099003752 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 195099003753 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 195099003754 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 195099003755 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 195099003756 Uncharacterized conserved protein [Function unknown]; Region: COG4121 195099003757 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 195099003758 AMIN domain; Region: AMIN; pfam11741 195099003759 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 195099003760 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 195099003761 active site 195099003762 metal binding site [ion binding]; metal-binding site 195099003763 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 195099003764 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 195099003765 FMN binding site [chemical binding]; other site 195099003766 substrate binding site [chemical binding]; other site 195099003767 putative catalytic residue [active] 195099003768 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 195099003769 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 195099003770 active site 195099003771 HIGH motif; other site 195099003772 dimer interface [polypeptide binding]; other site 195099003773 KMSKS motif; other site 195099003774 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 195099003775 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 195099003776 Zn2+ binding site [ion binding]; other site 195099003777 Mg2+ binding site [ion binding]; other site 195099003778 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 195099003779 synthetase active site [active] 195099003780 NTP binding site [chemical binding]; other site 195099003781 metal binding site [ion binding]; metal-binding site 195099003782 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 195099003783 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 195099003784 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 195099003785 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 195099003786 putative nucleotide binding site [chemical binding]; other site 195099003787 uridine monophosphate binding site [chemical binding]; other site 195099003788 homohexameric interface [polypeptide binding]; other site 195099003789 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 195099003790 Peptidase family M23; Region: Peptidase_M23; pfam01551 195099003791 FtsX-like permease family; Region: FtsX; pfam02687 195099003792 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 195099003793 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 195099003794 Walker A/P-loop; other site 195099003795 ATP binding site [chemical binding]; other site 195099003796 Q-loop/lid; other site 195099003797 ABC transporter signature motif; other site 195099003798 Walker B; other site 195099003799 D-loop; other site 195099003800 H-loop/switch region; other site 195099003801 tRNA (guanine-N(7)-)-methyltransferase; Provisional; Region: PRK14121 195099003802 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 195099003803 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 195099003804 Interdomain contacts; other site 195099003805 Cytokine receptor motif; other site 195099003806 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 195099003807 Interdomain contacts; other site 195099003808 Cytokine receptor motif; other site 195099003809 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 195099003810 Interdomain contacts; other site 195099003811 Cytokine receptor motif; other site 195099003812 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 195099003813 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195099003814 RNA binding surface [nucleotide binding]; other site 195099003815 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 195099003816 active site 195099003817 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 195099003818 lysogenic bacteriophage. Targeted tRNA-Met-1. attL/R=ctgctaaatccaccatt. 195099003819 integrase; Provisional; Region: PRK09692 195099003820 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 195099003821 active site 195099003822 Int/Topo IB signature motif; other site 195099003823 Helix-turn-helix domain; Region: HTH_17; pfam12728 195099003824 DNA methylase; Region: N6_N4_Mtase; pfam01555 195099003825 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 195099003826 Replication initiation factor; Region: Rep_trans; pfam02486 195099003827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 195099003828 non-specific DNA binding site [nucleotide binding]; other site 195099003829 salt bridge; other site 195099003830 sequence-specific DNA binding site [nucleotide binding]; other site 195099003831 YopX protein; Region: YopX; pfam09643 195099003832 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 195099003833 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 195099003834 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 195099003835 Predicted transcriptional regulator [Transcription]; Region: COG2932 195099003836 Catalytic site [active] 195099003837 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 195099003838 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 195099003839 active site 195099003840 substrate binding site [chemical binding]; other site 195099003841 Mg2+ binding site [ion binding]; other site 195099003842 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 195099003843 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 195099003844 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 195099003845 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 195099003846 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 195099003847 Phage capsid family; Region: Phage_capsid; pfam05065 195099003848 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 195099003849 chromosome segregation protein; Provisional; Region: PRK03918 195099003850 Minor capsid protein; Region: Minor_capsid_2; pfam11114 195099003851 Phage portal protein; Region: Phage_portal; pfam04860 195099003852 Phage-related protein [Function unknown]; Region: COG4695 195099003853 PemK-like protein; Region: PemK; pfam02452 195099003854 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 195099003855 Phage terminase, small subunit; Region: Terminase_4; cl01525 195099003856 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 195099003857 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 195099003858 active site 195099003859 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 195099003860 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 195099003861 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 195099003862 TrkA-N domain; Region: TrkA_N; pfam02254 195099003863 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 195099003864 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195099003865 active site 195099003866 Malic enzyme, N-terminal domain; Region: malic; pfam00390 195099003867 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 195099003868 putative NAD(P) binding site [chemical binding]; other site 195099003869 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 195099003870 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 195099003871 active site 195099003872 HIGH motif; other site 195099003873 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 195099003874 active site 195099003875 KMSKS motif; other site 195099003876 SurA N-terminal domain; Region: SurA_N; pfam09312 195099003877 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 195099003878 biotin carboxylase; Validated; Region: PRK08462 195099003879 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 195099003880 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 195099003881 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 195099003882 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 195099003883 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 195099003884 carboxyltransferase (CT) interaction site; other site 195099003885 biotinylation site [posttranslational modification]; other site 195099003886 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 195099003887 trimer interface [polypeptide binding]; other site 195099003888 active site 195099003889 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 195099003890 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 195099003891 NAD(P) binding site [chemical binding]; other site 195099003892 homodimer interface [polypeptide binding]; other site 195099003893 substrate binding site [chemical binding]; other site 195099003894 active site 195099003895 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 195099003896 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 195099003897 inhibitor-cofactor binding pocket; inhibition site 195099003898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099003899 catalytic residue [active] 195099003900 Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain [General function prediction only]; Region: COG4310 195099003901 M28 Zn-Peptidases; Region: M28_like_3; cd05644 195099003902 active site 195099003903 metal binding site [ion binding]; metal-binding site 195099003904 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 195099003905 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 195099003906 Methyltransferase domain; Region: Methyltransf_23; pfam13489 195099003907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195099003908 S-adenosylmethionine binding site [chemical binding]; other site 195099003909 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 195099003910 HAD-superfamily phosphatase, subfamily IIIC; Region: HAD-SF-IIIC; TIGR01681 195099003911 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12880 195099003912 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 195099003913 dimer interface [polypeptide binding]; other site 195099003914 active site 195099003915 CoA binding pocket [chemical binding]; other site 195099003916 Phosphopantetheine attachment site; Region: PP-binding; cl09936 195099003917 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 195099003918 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 195099003919 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 195099003920 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 195099003921 acyl-activating enzyme (AAE) consensus motif; other site 195099003922 AMP binding site [chemical binding]; other site 195099003923 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 195099003924 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 195099003925 active site 195099003926 cosubstrate binding site; other site 195099003927 substrate binding site [chemical binding]; other site 195099003928 catalytic site [active] 195099003929 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 195099003930 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 195099003931 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 195099003932 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 195099003933 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 195099003934 ligand binding site; other site 195099003935 tetramer interface; other site 195099003936 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 195099003937 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 195099003938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195099003939 Coenzyme A binding pocket [chemical binding]; other site 195099003940 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 195099003941 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 195099003942 substrate binding site [chemical binding]; other site 195099003943 glutamase interaction surface [polypeptide binding]; other site 195099003944 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 195099003945 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 195099003946 putative active site [active] 195099003947 oxyanion strand; other site 195099003948 catalytic triad [active] 195099003949 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 195099003950 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 195099003951 Ligand Binding Site [chemical binding]; other site 195099003952 pseudaminic acid synthase; Region: PseI; TIGR03586 195099003953 NeuB family; Region: NeuB; pfam03102 195099003954 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 195099003955 NeuB binding interface [polypeptide binding]; other site 195099003956 putative substrate binding site [chemical binding]; other site 195099003957 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 195099003958 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 195099003959 NAD binding site [chemical binding]; other site 195099003960 substrate binding site [chemical binding]; other site 195099003961 active site 195099003962 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 195099003963 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 195099003964 inhibitor-cofactor binding pocket; inhibition site 195099003965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099003966 catalytic residue [active] 195099003967 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 195099003968 active site 195099003969 cosubstrate binding site; other site 195099003970 substrate binding site [chemical binding]; other site 195099003971 catalytic site [active] 195099003972 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 195099003973 NeuB family; Region: NeuB; pfam03102 195099003974 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 195099003975 NeuB binding interface [polypeptide binding]; other site 195099003976 putative substrate binding site [chemical binding]; other site 195099003977 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 195099003978 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 195099003979 active site 195099003980 homodimer interface [polypeptide binding]; other site 195099003981 FOG: CBS domain [General function prediction only]; Region: COG0517 195099003982 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 195099003983 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 195099003984 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 195099003985 Substrate binding site; other site 195099003986 metal-binding site 195099003987 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 195099003988 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 195099003989 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 195099003990 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 195099003991 ligand binding site; other site 195099003992 tetramer interface; other site 195099003993 flagellin modification protein A; Provisional; Region: PRK09186 195099003994 classical (c) SDR, subgroup 8; Region: SDR_c8; cd08930 195099003995 putative NAD(P) binding site [chemical binding]; other site 195099003996 active site 195099003997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 195099003998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 195099003999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 195099004000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 195099004001 flagellin; Provisional; Region: PRK13589 195099004002 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 195099004003 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 195099004004 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 195099004005 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 195099004006 flagellin; Reviewed; Region: PRK08411 195099004007 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 195099004008 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 195099004009 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 195099004010 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 195099004011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 195099004012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 195099004013 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 195099004014 UGMP family protein; Validated; Region: PRK09604 195099004015 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 195099004016 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 195099004017 active site 195099004018 Zn binding site [ion binding]; other site 195099004019 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 195099004020 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 195099004021 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 195099004022 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 195099004023 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 195099004024 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 195099004025 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 195099004026 Domain of unknown function (DUF814); Region: DUF814; pfam05670 195099004027 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 195099004028 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 195099004029 GTP binding site; other site 195099004030 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 195099004031 dimerization interface [polypeptide binding]; other site 195099004032 substrate binding site [chemical binding]; other site 195099004033 active site 195099004034 calcium binding site [ion binding]; other site 195099004035 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 195099004036 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 195099004037 ABC-ATPase subunit interface; other site 195099004038 dimer interface [polypeptide binding]; other site 195099004039 putative PBP binding regions; other site 195099004040 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 195099004041 ABC-ATPase subunit interface; other site 195099004042 dimer interface [polypeptide binding]; other site 195099004043 putative PBP binding regions; other site 195099004044 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 195099004045 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 195099004046 Walker A/P-loop; other site 195099004047 ATP binding site [chemical binding]; other site 195099004048 Q-loop/lid; other site 195099004049 ABC transporter signature motif; other site 195099004050 Walker B; other site 195099004051 D-loop; other site 195099004052 H-loop/switch region; other site 195099004053 Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit [Inorganic ion transport and metabolism]; Region: NrfA; COG3303 195099004054 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 195099004055 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 195099004056 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 195099004057 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 195099004058 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 195099004059 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 195099004060 putative domain interface [polypeptide binding]; other site 195099004061 putative active site [active] 195099004062 catalytic site [active] 195099004063 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 195099004064 putative domain interface [polypeptide binding]; other site 195099004065 putative active site [active] 195099004066 catalytic site [active] 195099004067 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 195099004068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099004069 Walker A motif; other site 195099004070 ATP binding site [chemical binding]; other site 195099004071 Walker B motif; other site 195099004072 arginine finger; other site 195099004073 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 195099004074 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 195099004075 Domain of unknown function DUF20; Region: UPF0118; pfam01594 195099004076 fumarate hydratase; Reviewed; Region: fumC; PRK00485 195099004077 Class II fumarases; Region: Fumarase_classII; cd01362 195099004078 active site 195099004079 tetramer interface [polypeptide binding]; other site 195099004080 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 195099004081 catalytic triad [active] 195099004082 putative active site [active] 195099004083 autotransporter-associated beta strand repeat; Region: autotrns_rpt; TIGR02601 195099004084 Autotransporter beta-domain; Region: Autotransporter; pfam03797 195099004085 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 195099004086 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 195099004087 glutaminase active site [active] 195099004088 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 195099004089 dimer interface [polypeptide binding]; other site 195099004090 active site 195099004091 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 195099004092 dimer interface [polypeptide binding]; other site 195099004093 active site 195099004094 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 195099004095 hypothetical protein; Provisional; Region: PRK08444 195099004096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195099004097 FeS/SAM binding site; other site 195099004098 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 195099004099 Sulfate transporter family; Region: Sulfate_transp; pfam00916 195099004100 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 195099004101 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195099004102 active site 195099004103 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 195099004104 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 195099004105 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 195099004106 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 195099004107 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 195099004108 active site 195099004109 dimerization interface [polypeptide binding]; other site 195099004110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099004111 Major Facilitator Superfamily; Region: MFS_1; pfam07690 195099004112 putative substrate translocation pore; other site 195099004113 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 195099004114 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 195099004115 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 195099004116 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 195099004117 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 195099004118 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 195099004119 G1 box; other site 195099004120 putative GEF interaction site [polypeptide binding]; other site 195099004121 GTP/Mg2+ binding site [chemical binding]; other site 195099004122 Switch I region; other site 195099004123 G2 box; other site 195099004124 G3 box; other site 195099004125 Switch II region; other site 195099004126 G4 box; other site 195099004127 G5 box; other site 195099004128 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 195099004129 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 195099004130 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 195099004131 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 195099004132 flavodoxin FldA; Validated; Region: PRK09267 195099004133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4378 195099004134 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 195099004135 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 195099004136 tetramer interface [polypeptide binding]; other site 195099004137 heme binding pocket [chemical binding]; other site 195099004138 NADPH binding site [chemical binding]; other site 195099004139 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 195099004140 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 195099004141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 195099004142 YheO-like PAS domain; Region: PAS_6; pfam08348 195099004143 HTH domain; Region: HTH_22; pfam13309 195099004144 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 195099004145 homotrimer interaction site [polypeptide binding]; other site 195099004146 putative active site [active] 195099004147 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 195099004148 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 195099004149 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 195099004150 catalytic residue [active] 195099004151 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 195099004152 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 195099004153 tetramer interface [polypeptide binding]; other site 195099004154 active site 195099004155 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 195099004156 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 195099004157 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 195099004158 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 195099004159 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415 195099004160 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 195099004161 NAD binding site [chemical binding]; other site 195099004162 homotetramer interface [polypeptide binding]; other site 195099004163 homodimer interface [polypeptide binding]; other site 195099004164 substrate binding site [chemical binding]; other site 195099004165 active site 195099004166 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 195099004167 triosephosphate isomerase; Provisional; Region: PRK14565 195099004168 substrate binding site [chemical binding]; other site 195099004169 dimer interface [polypeptide binding]; other site 195099004170 catalytic triad [active] 195099004171 Phosphoglycerate kinase; Region: PGK; pfam00162 195099004172 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 195099004173 substrate binding site [chemical binding]; other site 195099004174 hinge regions; other site 195099004175 ADP binding site [chemical binding]; other site 195099004176 catalytic site [active] 195099004177 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 195099004178 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 195099004179 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 195099004180 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 195099004181 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 195099004182 active site 195099004183 (T/H)XGH motif; other site 195099004184 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 195099004185 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 195099004186 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 195099004187 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 195099004188 active site 195099004189 substrate binding site [chemical binding]; other site 195099004190 metal binding site [ion binding]; metal-binding site 195099004191 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK08455 195099004192 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 195099004193 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 195099004194 Cytochrome P450; Region: p450; cl12078 195099004195 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 195099004196 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 195099004197 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 195099004198 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 195099004199 Ligand binding site; other site 195099004200 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 195099004201 active site 195099004202 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 195099004203 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 195099004204 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 195099004205 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 195099004206 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 195099004207 active site 195099004208 catalytic site [active] 195099004209 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 195099004210 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 195099004211 Substrate binding site; other site 195099004212 Mg++ binding site; other site 195099004213 metal-binding site 195099004214 Mg++ binding site; other site 195099004215 metal-binding site 195099004216 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 195099004217 dimer interface [polypeptide binding]; other site 195099004218 active site 195099004219 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 195099004220 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 195099004221 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 195099004222 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 195099004223 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 195099004224 NADP-binding site; other site 195099004225 homotetramer interface [polypeptide binding]; other site 195099004226 substrate binding site [chemical binding]; other site 195099004227 homodimer interface [polypeptide binding]; other site 195099004228 active site 195099004229 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 195099004230 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 195099004231 NADP binding site [chemical binding]; other site 195099004232 active site 195099004233 putative substrate binding site [chemical binding]; other site 195099004234 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 195099004235 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 195099004236 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 195099004237 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 195099004238 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 195099004239 KpsF/GutQ family protein; Region: kpsF; TIGR00393 195099004240 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 195099004241 putative active site [active] 195099004242 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 195099004243 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 195099004244 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 195099004245 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 195099004246 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 195099004247 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 195099004248 Walker A/P-loop; other site 195099004249 ATP binding site [chemical binding]; other site 195099004250 Q-loop/lid; other site 195099004251 ABC transporter signature motif; other site 195099004252 Walker B; other site 195099004253 D-loop; other site 195099004254 H-loop/switch region; other site 195099004255 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 195099004256 ABC-2 type transporter; Region: ABC2_membrane; cl17235 195099004257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 195099004258 dUTPase; Region: dUTPase_2; pfam08761 195099004259 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 195099004260 active site 195099004261 homodimer interface [polypeptide binding]; other site 195099004262 metal binding site [ion binding]; metal-binding site 195099004263 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 195099004264 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 195099004265 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 195099004266 Ligand Binding Site [chemical binding]; other site 195099004267 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 195099004268 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 195099004269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195099004270 FeS/SAM binding site; other site 195099004271 peptide chain release factor 2; Validated; Region: prfB; PRK00578 195099004272 This domain is found in peptide chain release factors; Region: PCRF; smart00937 195099004273 RF-1 domain; Region: RF-1; pfam00472 195099004274 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 195099004275 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 195099004276 Permutation of conserved domain; other site 195099004277 active site 195099004278 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 195099004279 thiamine monophosphate kinase; Provisional; Region: PRK05731 195099004280 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 195099004281 ATP binding site [chemical binding]; other site 195099004282 dimerization interface [polypeptide binding]; other site 195099004283 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 195099004284 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 195099004285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 195099004286 S-adenosylmethionine binding site [chemical binding]; other site 195099004287 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 195099004288 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 195099004289 Rod binding protein; Region: Rod-binding; cl01626 195099004290 FlgN protein; Region: FlgN; pfam05130 195099004291 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 195099004292 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 195099004293 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 195099004294 hypothetical protein; Provisional; Region: PRK10621 195099004295 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 195099004296 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 195099004297 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 195099004298 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 195099004299 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 195099004300 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 195099004301 Walker A motif; other site 195099004302 ATP binding site [chemical binding]; other site 195099004303 Walker B motif; other site 195099004304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195099004305 AAA domain; Region: AAA_22; pfam13401 195099004306 Walker A motif; other site 195099004307 ATP binding site [chemical binding]; other site 195099004308 Walker B motif; other site 195099004309 arginine finger; other site 195099004310 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 195099004311 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 195099004312 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 195099004313 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 195099004314 dimer interface [polypeptide binding]; other site 195099004315 PYR/PP interface [polypeptide binding]; other site 195099004316 TPP binding site [chemical binding]; other site 195099004317 substrate binding site [chemical binding]; other site 195099004318 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 195099004319 Domain of unknown function; Region: EKR; pfam10371 195099004320 4Fe-4S binding domain; Region: Fer4_6; pfam12837 195099004321 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 195099004322 TPP-binding site [chemical binding]; other site 195099004323 dimer interface [polypeptide binding]; other site 195099004324 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 195099004325 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195099004326 motif II; other site 195099004327 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 195099004328 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 195099004329 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 195099004330 ligand binding site [chemical binding]; other site 195099004331 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 195099004332 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 195099004333 23S rRNA interface [nucleotide binding]; other site 195099004334 L3 interface [polypeptide binding]; other site 195099004335 Part of AAA domain; Region: AAA_19; pfam13245 195099004336 putative recombination protein RecB; Provisional; Region: PRK13909 195099004337 Family description; Region: UvrD_C_2; pfam13538 195099004338 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 195099004339 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 195099004340 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 195099004341 FixH; Region: FixH; pfam05751 195099004342 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 195099004343 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 195099004344 Cytochrome c; Region: Cytochrom_C; cl11414 195099004345 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 195099004346 cytochrome c oxidase, cbb3-type, CcoQ subunit, epsilon-Proteobacterial; Region: cbb3_Q_epsi; TIGR02736 195099004347 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 195099004348 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 195099004349 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 195099004350 Low-spin heme binding site [chemical binding]; other site 195099004351 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 195099004352 D-pathway; other site 195099004353 Putative water exit pathway; other site 195099004354 Binuclear center (active site) [active] 195099004355 K-pathway; other site 195099004356 Putative proton exit pathway; other site 195099004357 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195099004358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195099004359 active site 195099004360 phosphorylation site [posttranslational modification] 195099004361 intermolecular recognition site; other site 195099004362 dimerization interface [polypeptide binding]; other site 195099004363 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195099004364 DNA binding site [nucleotide binding] 195099004365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 195099004366 PAS domain; Region: PAS_9; pfam13426 195099004367 putative active site [active] 195099004368 heme pocket [chemical binding]; other site 195099004369 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195099004370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195099004371 ATP binding site [chemical binding]; other site 195099004372 Mg2+ binding site [ion binding]; other site 195099004373 G-X-G motif; other site 195099004374 Uncharacterized conserved protein [Function unknown]; Region: COG2836 195099004375 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 195099004376 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 195099004377 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 195099004378 catalytic site [active] 195099004379 subunit interface [polypeptide binding]; other site 195099004380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2952 195099004381 Uncharacterized conserved protein [Function unknown]; Region: COG3334 195099004382 Flagellar FliJ protein; Region: FliJ; pfam02050 195099004383 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 195099004384 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 195099004385 GDP-binding site [chemical binding]; other site 195099004386 ACT binding site; other site 195099004387 IMP binding site; other site 195099004388 putative inner membrane protein; Provisional; Region: PRK11099 195099004389 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 195099004390 Sulphur transport; Region: Sulf_transp; pfam04143 195099004391 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 195099004392 CPxP motif; other site 195099004393 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 195099004394 Na binding site [ion binding]; other site 195099004395 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 195099004396 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 195099004397 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 195099004398 Glutamate binding site [chemical binding]; other site 195099004399 NAD binding site [chemical binding]; other site 195099004400 catalytic residues [active] 195099004401 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 195099004402 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 195099004403 dimerization interface [polypeptide binding]; other site 195099004404 putative ATP binding site [chemical binding]; other site 195099004405 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 195099004406 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 195099004407 CPxP motif; other site 195099004408 Cache domain; Region: Cache_1; pfam02743 195099004409 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 195099004410 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 195099004411 dimer interface [polypeptide binding]; other site 195099004412 putative CheW interface [polypeptide binding]; other site 195099004413 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 195099004414 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 195099004415 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 195099004416 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 195099004417 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 195099004418 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 195099004419 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 195099004420 [4Fe-4S] binding site [ion binding]; other site 195099004421 molybdopterin cofactor binding site; other site 195099004422 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 195099004423 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 195099004424 molybdopterin cofactor binding site; other site 195099004425 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 195099004426 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 195099004427 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 195099004428 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 195099004429 dimer interface [polypeptide binding]; other site 195099004430 active site 195099004431 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 195099004432 catalytic residues [active] 195099004433 substrate binding site [chemical binding]; other site 195099004434 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 195099004435 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 195099004436 Multicopper oxidase; Region: Cu-oxidase; pfam00394 195099004437 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 195099004438 ThiS family; Region: ThiS; pfam02597 195099004439 charged pocket; other site 195099004440 hydrophobic patch; other site 195099004441 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 195099004442 MoaE homodimer interface [polypeptide binding]; other site 195099004443 MoaD interaction [polypeptide binding]; other site 195099004444 active site residues [active] 195099004445 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 195099004446 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 195099004447 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 195099004448 dimer interface [polypeptide binding]; other site 195099004449 putative functional site; other site 195099004450 putative MPT binding site; other site 195099004451 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 195099004452 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 195099004453 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 195099004454 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 195099004455 dimerization interface [polypeptide binding]; other site 195099004456 putative ATP binding site [chemical binding]; other site 195099004457 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 195099004458 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 195099004459 CoA-binding site [chemical binding]; other site 195099004460 ATP-binding [chemical binding]; other site 195099004461 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 195099004462 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 195099004463 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 195099004464 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 195099004465 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 195099004466 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 195099004467 AAA domain; Region: AAA_14; pfam13173 195099004468 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 195099004469 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 195099004470 dimerization interface [polypeptide binding]; other site 195099004471 DPS ferroxidase diiron center [ion binding]; other site 195099004472 ion pore; other site 195099004473 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 195099004474 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 195099004475 active site 195099004476 dimer interface [polypeptide binding]; other site 195099004477 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 195099004478 dimer interface [polypeptide binding]; other site 195099004479 active site 195099004480 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 195099004481 active site 195099004482 tetramer interface; other site 195099004483 acetyl-CoA synthetase; Provisional; Region: PRK00174 195099004484 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 195099004485 active site 195099004486 CoA binding site [chemical binding]; other site 195099004487 acyl-activating enzyme (AAE) consensus motif; other site 195099004488 AMP binding site [chemical binding]; other site 195099004489 acetate binding site [chemical binding]; other site 195099004490 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 195099004491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195099004492 Walker A/P-loop; other site 195099004493 ATP binding site [chemical binding]; other site 195099004494 Q-loop/lid; other site 195099004495 ABC transporter signature motif; other site 195099004496 Walker B; other site 195099004497 D-loop; other site 195099004498 H-loop/switch region; other site 195099004499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099004500 dimer interface [polypeptide binding]; other site 195099004501 conserved gate region; other site 195099004502 putative PBP binding loops; other site 195099004503 ABC-ATPase subunit interface; other site 195099004504 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 195099004505 PBP superfamily domain; Region: PBP_like_2; pfam12849 195099004506 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 195099004507 putative active site [active] 195099004508 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 195099004509 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 195099004510 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 195099004511 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 195099004512 EamA-like transporter family; Region: EamA; cl17759 195099004513 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 195099004514 Predicted transcriptional regulators [Transcription]; Region: COG1733 195099004515 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 195099004516 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 195099004517 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 195099004518 putative NAD(P) binding site [chemical binding]; other site 195099004519 putative substrate binding site [chemical binding]; other site 195099004520 catalytic Zn binding site [ion binding]; other site 195099004521 structural Zn binding site [ion binding]; other site 195099004522 dimer interface [polypeptide binding]; other site 195099004523 AAA domain; Region: AAA_13; pfam13166 195099004524 Fic family protein [Function unknown]; Region: COG3177 195099004525 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 195099004526 Fic/DOC family; Region: Fic; pfam02661 195099004527 HsdM N-terminal domain; Region: HsdM_N; pfam12161 195099004528 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 195099004529 Methyltransferase domain; Region: Methyltransf_26; pfam13659 195099004530 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 195099004531 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 195099004532 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 195099004533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099004534 putative substrate translocation pore; other site 195099004535 Predicted permeases [General function prediction only]; Region: COG0701 195099004536 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 195099004537 dimerization interface [polypeptide binding]; other site 195099004538 putative DNA binding site [nucleotide binding]; other site 195099004539 putative Zn2+ binding site [ion binding]; other site 195099004540 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 195099004541 Low molecular weight phosphatase family; Region: LMWPc; cl00105 195099004542 active site 195099004543 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 195099004544 Sodium Bile acid symporter family; Region: SBF; cl17470 195099004545 Cache domain; Region: Cache_1; pfam02743 195099004546 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 195099004547 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 195099004548 dimer interface [polypeptide binding]; other site 195099004549 putative CheW interface [polypeptide binding]; other site 195099004550 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15490 195099004551 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 195099004552 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 195099004553 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 195099004554 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 195099004555 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 195099004556 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 195099004557 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 195099004558 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713 195099004559 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 195099004560 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 195099004561 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 195099004562 4Fe-4S binding domain; Region: Fer4; cl02805 195099004563 4Fe-4S binding domain; Region: Fer4; pfam00037 195099004564 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 195099004565 NADH dehydrogenase subunit G; Validated; Region: PRK08493 195099004566 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 195099004567 catalytic loop [active] 195099004568 iron binding site [ion binding]; other site 195099004569 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 195099004570 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 195099004571 NADH dehydrogenase subunit D; Validated; Region: PRK06075 195099004572 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 195099004573 NADH dehydrogenase subunit C; Provisional; Region: PRK08491 195099004574 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 195099004575 NADH dehydrogenase subunit B; Validated; Region: PRK06411 195099004576 NADH dehydrogenase subunit A; Validated; Region: PRK08489 195099004577 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 195099004578 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 195099004579 Walker A/P-loop; other site 195099004580 ATP binding site [chemical binding]; other site 195099004581 Q-loop/lid; other site 195099004582 ABC transporter signature motif; other site 195099004583 Walker B; other site 195099004584 D-loop; other site 195099004585 H-loop/switch region; other site 195099004586 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 195099004587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195099004588 Walker A/P-loop; other site 195099004589 ATP binding site [chemical binding]; other site 195099004590 Q-loop/lid; other site 195099004591 ABC transporter signature motif; other site 195099004592 Walker B; other site 195099004593 D-loop; other site 195099004594 H-loop/switch region; other site 195099004595 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 195099004596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195099004597 putative PBP binding loops; other site 195099004598 ABC-ATPase subunit interface; other site 195099004599 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 195099004600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 195099004601 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 195099004602 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 195099004603 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 195099004604 FAD binding domain; Region: FAD_binding_4; pfam01565 195099004605 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 195099004606 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 195099004607 heme-binding site [chemical binding]; other site 195099004608 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 195099004609 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 195099004610 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 195099004611 Walker A/P-loop; other site 195099004612 ATP binding site [chemical binding]; other site 195099004613 Q-loop/lid; other site 195099004614 ABC transporter signature motif; other site 195099004615 Walker B; other site 195099004616 D-loop; other site 195099004617 H-loop/switch region; other site 195099004618 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 195099004619 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 195099004620 rRNA binding site [nucleotide binding]; other site 195099004621 predicted 30S ribosome binding site; other site 195099004622 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 195099004623 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 195099004624 30S ribosomal protein S13; Region: bact_S13; TIGR03631 195099004625 30S ribosomal protein S11; Validated; Region: PRK05309 195099004626 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 195099004627 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 195099004628 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195099004629 RNA binding surface [nucleotide binding]; other site 195099004630 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 195099004631 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 195099004632 alphaNTD homodimer interface [polypeptide binding]; other site 195099004633 alphaNTD - beta interaction site [polypeptide binding]; other site 195099004634 alphaNTD - beta' interaction site [polypeptide binding]; other site 195099004635 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 195099004636 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 195099004637 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 195099004638 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 195099004639 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 195099004640 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 195099004641 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 195099004642 NAD binding site [chemical binding]; other site 195099004643 dimerization interface [polypeptide binding]; other site 195099004644 product binding site; other site 195099004645 substrate binding site [chemical binding]; other site 195099004646 zinc binding site [ion binding]; other site 195099004647 catalytic residues [active] 195099004648 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 195099004649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195099004650 active site 195099004651 motif I; other site 195099004652 motif II; other site 195099004653 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 195099004654 putative active site pocket [active] 195099004655 4-fold oligomerization interface [polypeptide binding]; other site 195099004656 metal binding residues [ion binding]; metal-binding site 195099004657 3-fold/trimer interface [polypeptide binding]; other site 195099004658 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 195099004659 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 195099004660 putative active site [active] 195099004661 oxyanion strand; other site 195099004662 catalytic triad [active] 195099004663 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 195099004664 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 195099004665 catalytic residues [active] 195099004666 Protein of unknown function (DUF511); Region: DUF511; cl01114 195099004667 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 195099004668 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 195099004669 substrate binding site [chemical binding]; other site 195099004670 glutamase interaction surface [polypeptide binding]; other site 195099004671 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 195099004672 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 195099004673 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 195099004674 metal binding site [ion binding]; metal-binding site 195099004675 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 195099004676 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 195099004677 putative trimer interface [polypeptide binding]; other site 195099004678 putative CoA binding site [chemical binding]; other site 195099004679 antiporter inner membrane protein; Provisional; Region: PRK11670 195099004680 Domain of unknown function DUF59; Region: DUF59; pfam01883 195099004681 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 195099004682 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 195099004683 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 195099004684 substrate binding site; other site 195099004685 dimer interface; other site 195099004686 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 195099004687 homotrimer interaction site [polypeptide binding]; other site 195099004688 zinc binding site [ion binding]; other site 195099004689 CDP-binding sites; other site 195099004690 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 195099004691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195099004692 active site 195099004693 intermolecular recognition site; other site 195099004694 dimerization interface [polypeptide binding]; other site 195099004695 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046 195099004696 ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747 195099004697 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 195099004698 tetramer interfaces [polypeptide binding]; other site 195099004699 binuclear metal-binding site [ion binding]; other site 195099004700 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 195099004701 peptide chain release factor 1; Validated; Region: prfA; PRK00591 195099004702 This domain is found in peptide chain release factors; Region: PCRF; smart00937 195099004703 RF-1 domain; Region: RF-1; pfam00472 195099004704 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 195099004705 heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109 195099004706 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 195099004707 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 195099004708 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 195099004709 N-terminal plug; other site 195099004710 ligand-binding site [chemical binding]; other site 195099004711 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 195099004712 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 195099004713 ABC-ATPase subunit interface; other site 195099004714 dimer interface [polypeptide binding]; other site 195099004715 putative PBP binding regions; other site 195099004716 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 195099004717 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 195099004718 Walker A/P-loop; other site 195099004719 ATP binding site [chemical binding]; other site 195099004720 Q-loop/lid; other site 195099004721 ABC transporter signature motif; other site 195099004722 Walker B; other site 195099004723 D-loop; other site 195099004724 H-loop/switch region; other site 195099004725 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 195099004726 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 195099004727 putative binding site residues; other site 195099004728 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 195099004729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099004730 putative substrate translocation pore; other site 195099004731 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 195099004732 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 195099004733 minor groove reading motif; other site 195099004734 helix-hairpin-helix signature motif; other site 195099004735 substrate binding pocket [chemical binding]; other site 195099004736 active site 195099004737 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 195099004738 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 195099004739 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 195099004740 catalytic motif [active] 195099004741 Zn binding site [ion binding]; other site 195099004742 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 195099004743 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 195099004744 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 195099004745 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 195099004746 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 195099004747 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 195099004748 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 195099004749 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 195099004750 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 195099004751 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 195099004752 TonB system transport protein ExbD, group 2; Region: ExbD_2; TIGR02804 195099004753 Protein of unknown function (DUF3135); Region: DUF3135; pfam11333 195099004754 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 195099004755 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 195099004756 Ligand Binding Site [chemical binding]; other site 195099004757 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 195099004758 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 195099004759 Tetramer interface [polypeptide binding]; other site 195099004760 active site 195099004761 FMN-binding site [chemical binding]; other site 195099004762 ribonuclease III; Reviewed; Region: rnc; PRK00102 195099004763 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 195099004764 dimerization interface [polypeptide binding]; other site 195099004765 active site 195099004766 metal binding site [ion binding]; metal-binding site 195099004767 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 195099004768 dsRNA binding site [nucleotide binding]; other site 195099004769 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 195099004770 RNA/DNA hybrid binding site [nucleotide binding]; other site 195099004771 active site 195099004772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 195099004773 TPR motif; other site 195099004774 binding surface 195099004775 Tetratricopeptide repeat; Region: TPR_16; pfam13432 195099004776 Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have...; Region: ZZ; cl00295 195099004777 Zinc-binding sites [ion binding]; other site 195099004778 zinc cluster 1 [ion binding]; other site 195099004779 putative charged binding surface; other site 195099004780 putative hydrophobic binding surface; other site 195099004781 zinc cluster 2 [ion binding]; other site 195099004782 DNA primase, catalytic core; Region: dnaG; TIGR01391 195099004783 CHC2 zinc finger; Region: zf-CHC2; pfam01807 195099004784 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 195099004785 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 195099004786 active site 195099004787 metal binding site [ion binding]; metal-binding site 195099004788 interdomain interaction site; other site 195099004789 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 195099004790 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 195099004791 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 195099004792 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 195099004793 hypothetical protein; Provisional; Region: PRK03762 195099004794 PDZ domain; Region: PDZ_2; pfam13180 195099004795 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 195099004796 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 195099004797 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 195099004798 substrate binding pocket [chemical binding]; other site 195099004799 chain length determination region; other site 195099004800 substrate-Mg2+ binding site; other site 195099004801 catalytic residues [active] 195099004802 aspartate-rich region 1; other site 195099004803 active site lid residues [active] 195099004804 aspartate-rich region 2; other site 195099004805 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 195099004806 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 195099004807 TPP-binding site [chemical binding]; other site 195099004808 dimer interface [polypeptide binding]; other site 195099004809 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 195099004810 PYR/PP interface [polypeptide binding]; other site 195099004811 dimer interface [polypeptide binding]; other site 195099004812 TPP binding site [chemical binding]; other site 195099004813 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 195099004814 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 195099004815 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 195099004816 Permease; Region: Permease; pfam02405 195099004817 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 195099004818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195099004819 Walker A/P-loop; other site 195099004820 ATP binding site [chemical binding]; other site 195099004821 Q-loop/lid; other site 195099004822 ABC transporter signature motif; other site 195099004823 Walker B; other site 195099004824 D-loop; other site 195099004825 H-loop/switch region; other site 195099004826 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 195099004827 mce related protein; Region: MCE; pfam02470 195099004828 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 195099004829 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 195099004830 active site 195099004831 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 195099004832 NlpC/P60 family; Region: NLPC_P60; pfam00877 195099004833 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 195099004834 Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004 195099004835 Putative motility protein; Region: YjfB_motility; pfam14070 195099004836 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 195099004837 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 195099004838 Predicted membrane protein [Function unknown]; Region: COG4393 195099004839 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 195099004840 Uncharacterized conserved protein [Function unknown]; Region: COG3350 195099004841 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 195099004842 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 195099004843 FtsX-like permease family; Region: FtsX; pfam02687 195099004844 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 195099004845 FtsX-like permease family; Region: FtsX; pfam02687 195099004846 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 195099004847 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 195099004848 Walker A/P-loop; other site 195099004849 ATP binding site [chemical binding]; other site 195099004850 Q-loop/lid; other site 195099004851 ABC transporter signature motif; other site 195099004852 Walker B; other site 195099004853 D-loop; other site 195099004854 H-loop/switch region; other site 195099004855 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 195099004856 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 195099004857 catalytic residues [active] 195099004858 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 195099004859 Predicted metal-binding protein [General function prediction only]; Region: COG3019 195099004860 DNA ligase; Provisional; Region: PRK09125 195099004861 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 195099004862 DNA binding site [nucleotide binding] 195099004863 active site 195099004864 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 195099004865 DNA binding site [nucleotide binding] 195099004866 AMIN domain; Region: AMIN; pfam11741 195099004867 enolase; Provisional; Region: eno; PRK00077 195099004868 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 195099004869 dimer interface [polypeptide binding]; other site 195099004870 metal binding site [ion binding]; metal-binding site 195099004871 substrate binding pocket [chemical binding]; other site 195099004872 recombinase A; Provisional; Region: recA; PRK09354 195099004873 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 195099004874 hexamer interface [polypeptide binding]; other site 195099004875 Walker A motif; other site 195099004876 ATP binding site [chemical binding]; other site 195099004877 Walker B motif; other site 195099004878 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 195099004879 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 195099004880 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 195099004881 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 195099004882 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 195099004883 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 195099004884 active site 195099004885 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 195099004886 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 195099004887 dimer interface [polypeptide binding]; other site 195099004888 active site 195099004889 citrylCoA binding site [chemical binding]; other site 195099004890 NADH binding [chemical binding]; other site 195099004891 cationic pore residues; other site 195099004892 oxalacetate/citrate binding site [chemical binding]; other site 195099004893 coenzyme A binding site [chemical binding]; other site 195099004894 catalytic triad [active] 195099004895 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 195099004896 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 195099004897 biotin synthase; Provisional; Region: PRK08508 195099004898 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195099004899 FeS/SAM binding site; other site 195099004900 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 195099004901 DNA topoisomerase I; Validated; Region: PRK05582 195099004902 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 195099004903 active site 195099004904 interdomain interaction site; other site 195099004905 putative metal-binding site [ion binding]; other site 195099004906 nucleotide binding site [chemical binding]; other site 195099004907 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 195099004908 domain I; other site 195099004909 DNA binding groove [nucleotide binding] 195099004910 phosphate binding site [ion binding]; other site 195099004911 domain II; other site 195099004912 domain III; other site 195099004913 nucleotide binding site [chemical binding]; other site 195099004914 catalytic site [active] 195099004915 domain IV; other site 195099004916 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 195099004917 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 195099004918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195099004919 putative substrate translocation pore; other site 195099004920 Major Facilitator Superfamily; Region: MFS_1; pfam07690 195099004921 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 195099004922 SecY translocase; Region: SecY; pfam00344 195099004923 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 195099004924 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 195099004925 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 195099004926 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 195099004927 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 195099004928 5S rRNA interface [nucleotide binding]; other site 195099004929 23S rRNA interface [nucleotide binding]; other site 195099004930 L5 interface [polypeptide binding]; other site 195099004931 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 195099004932 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 195099004933 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 195099004934 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 195099004935 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 195099004936 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 195099004937 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 195099004938 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 195099004939 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 195099004940 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 195099004941 RNA binding site [nucleotide binding]; other site 195099004942 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 195099004943 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 195099004944 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 195099004945 putative translocon interaction site; other site 195099004946 23S rRNA interface [nucleotide binding]; other site 195099004947 signal recognition particle (SRP54) interaction site; other site 195099004948 L23 interface [polypeptide binding]; other site 195099004949 trigger factor interaction site; other site 195099004950 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 195099004951 23S rRNA interface [nucleotide binding]; other site 195099004952 5S rRNA interface [nucleotide binding]; other site 195099004953 putative antibiotic binding site [chemical binding]; other site 195099004954 L25 interface [polypeptide binding]; other site 195099004955 L27 interface [polypeptide binding]; other site 195099004956 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 195099004957 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 195099004958 G-X-X-G motif; other site 195099004959 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 195099004960 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 195099004961 putative translocon binding site; other site 195099004962 protein-rRNA interface [nucleotide binding]; other site 195099004963 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 195099004964 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 195099004965 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 195099004966 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 195099004967 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 195099004968 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 195099004969 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 195099004970 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 195099004971 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 195099004972 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195099004973 RNA binding surface [nucleotide binding]; other site 195099004974 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 195099004975 active site 195099004976 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 195099004977 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 195099004978 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 195099004979 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 195099004980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195099004981 S-adenosylmethionine binding site [chemical binding]; other site 195099004982 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 195099004983 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 195099004984 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195099004985 FeS/SAM binding site; other site 195099004986 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 195099004987 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 195099004988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195099004989 Coenzyme A binding pocket [chemical binding]; other site 195099004990 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 195099004991 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 195099004992 substrate binding site [chemical binding]; other site 195099004993 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 195099004994 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 195099004995 substrate binding site [chemical binding]; other site 195099004996 ligand binding site [chemical binding]; other site 195099004997 tartrate dehydrogenase; Region: TTC; TIGR02089 195099004998 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 195099004999 2-isopropylmalate synthase; Validated; Region: PRK00915 195099005000 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 195099005001 active site 195099005002 catalytic residues [active] 195099005003 metal binding site [ion binding]; metal-binding site 195099005004 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 195099005005 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 195099005006 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 195099005007 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 195099005008 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 195099005009 homoserine O-succinyltransferase; Region: metA; TIGR01001 195099005010 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 195099005011 proposed active site lysine [active] 195099005012 conserved cys residue [active] 195099005013 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 195099005014 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 195099005015 homodimer interface [polypeptide binding]; other site 195099005016 substrate-cofactor binding pocket; other site 195099005017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195099005018 catalytic residue [active] 195099005019 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 195099005020 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 195099005021 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 195099005022 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 195099005023 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 195099005024 active site 195099005025 putative DNA-binding cleft [nucleotide binding]; other site 195099005026 dimer interface [polypeptide binding]; other site