-- dump date 20140619_022114 -- class Genbank::misc_feature -- table misc_feature_note -- id note 718271000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 718271000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271000003 Walker A motif; other site 718271000004 ATP binding site [chemical binding]; other site 718271000005 Walker B motif; other site 718271000006 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 718271000007 DnaA box-binding interface [nucleotide binding]; other site 718271000008 DNA polymerase III subunit beta; Validated; Region: PRK05643 718271000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 718271000010 putative DNA binding surface [nucleotide binding]; other site 718271000011 dimer interface [polypeptide binding]; other site 718271000012 beta-clamp/clamp loader binding surface; other site 718271000013 beta-clamp/translesion DNA polymerase binding surface; other site 718271000014 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 718271000015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718271000016 Mg2+ binding site [ion binding]; other site 718271000017 G-X-G motif; other site 718271000018 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 718271000019 anchoring element; other site 718271000020 dimer interface [polypeptide binding]; other site 718271000021 ATP binding site [chemical binding]; other site 718271000022 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 718271000023 active site 718271000024 putative metal-binding site [ion binding]; other site 718271000025 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 718271000026 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 718271000027 sulfite oxidase; Provisional; Region: PLN00177 718271000028 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 718271000029 Moco binding site; other site 718271000030 metal coordination site [ion binding]; other site 718271000031 dimerization interface [polypeptide binding]; other site 718271000032 Predicted permease [General function prediction only]; Region: COG2056 718271000033 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 718271000034 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 718271000035 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 718271000036 active site 718271000037 dimer interface [polypeptide binding]; other site 718271000038 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 718271000039 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 718271000040 active site 718271000041 FMN binding site [chemical binding]; other site 718271000042 substrate binding site [chemical binding]; other site 718271000043 3Fe-4S cluster binding site [ion binding]; other site 718271000044 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 718271000045 domain interface; other site 718271000046 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 718271000047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718271000048 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 718271000049 RNA/DNA hybrid binding site [nucleotide binding]; other site 718271000050 active site 718271000051 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 718271000052 Helix-hairpin-helix motif; Region: HHH; pfam00633 718271000053 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 718271000054 non-heme iron binding site [ion binding]; other site 718271000055 dimer interface [polypeptide binding]; other site 718271000056 Rubrerythrin [Energy production and conversion]; Region: COG1592 718271000057 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 718271000058 binuclear metal center [ion binding]; other site 718271000059 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 718271000060 iron binding site [ion binding]; other site 718271000061 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 718271000062 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 718271000063 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 718271000064 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 718271000065 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 718271000066 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 718271000067 Ligand Binding Site [chemical binding]; other site 718271000068 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 718271000069 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 718271000070 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718271000071 dimer interface [polypeptide binding]; other site 718271000072 putative CheW interface [polypeptide binding]; other site 718271000073 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 718271000074 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 718271000075 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 718271000076 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 718271000077 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 718271000078 active site 718271000079 adenylosuccinate lyase; Provisional; Region: PRK08470 718271000080 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 718271000081 tetramer interface [polypeptide binding]; other site 718271000082 active site 718271000083 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 718271000084 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 718271000085 ATP cone domain; Region: ATP-cone; pfam03477 718271000086 Class I ribonucleotide reductase; Region: RNR_I; cd01679 718271000087 active site 718271000088 dimer interface [polypeptide binding]; other site 718271000089 catalytic residues [active] 718271000090 effector binding site; other site 718271000091 R2 peptide binding site; other site 718271000092 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 718271000093 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718271000094 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 718271000095 CTP synthetase; Validated; Region: pyrG; PRK05380 718271000096 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 718271000097 Catalytic site [active] 718271000098 active site 718271000099 UTP binding site [chemical binding]; other site 718271000100 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 718271000101 active site 718271000102 putative oxyanion hole; other site 718271000103 catalytic triad [active] 718271000104 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 718271000105 DHH family; Region: DHH; pfam01368 718271000106 DHHA1 domain; Region: DHHA1; pfam02272 718271000107 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 718271000108 active site 718271000109 homodimer interface [polypeptide binding]; other site 718271000110 homotetramer interface [polypeptide binding]; other site 718271000111 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 718271000112 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 718271000113 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 718271000114 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 718271000115 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 718271000116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 718271000117 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 718271000118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271000119 putative substrate translocation pore; other site 718271000120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 718271000121 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 718271000122 Cytochrome c [Energy production and conversion]; Region: COG3258 718271000123 Cytochrome c; Region: Cytochrom_C; pfam00034 718271000124 Cytochrome c; Region: Cytochrom_C; pfam00034 718271000125 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 718271000126 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 718271000127 putative GEF interaction site [polypeptide binding]; other site 718271000128 Switch I region; other site 718271000129 G2 box; other site 718271000130 G3 box; other site 718271000131 Switch II region; other site 718271000132 GTP/Mg2+ binding site [chemical binding]; other site 718271000133 G4 box; other site 718271000134 G5 box; other site 718271000135 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 718271000136 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 718271000137 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 718271000138 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 718271000139 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 718271000140 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 718271000141 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 718271000142 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718271000143 Protein of unknown function (DUF342); Region: DUF342; pfam03961 718271000144 Hemerythrin; Region: Hemerythrin; cd12107 718271000145 Fe binding site [ion binding]; other site 718271000146 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 718271000147 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 718271000148 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 718271000149 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 718271000150 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 718271000151 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 718271000152 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 718271000153 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 718271000154 Ligand Binding Site [chemical binding]; other site 718271000155 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 718271000156 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 718271000157 putative active site [active] 718271000158 flagellar motor switch protein FliY; Validated; Region: PRK08432 718271000159 flagellar motor switch protein FliN; Region: fliN; TIGR02480 718271000160 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 718271000161 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 718271000162 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 718271000163 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718271000164 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 718271000165 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718271000166 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 718271000167 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 718271000168 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718271000169 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 718271000170 catalytic center binding site [active] 718271000171 ATP binding site [chemical binding]; other site 718271000172 Dehydroquinase class II; Region: DHquinase_II; pfam01220 718271000173 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 718271000174 trimer interface [polypeptide binding]; other site 718271000175 active site 718271000176 dimer interface [polypeptide binding]; other site 718271000177 chlorohydrolase; Provisional; Region: PRK08418 718271000178 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 718271000179 active site 718271000180 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 718271000181 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 718271000182 tandem repeat interface [polypeptide binding]; other site 718271000183 oligomer interface [polypeptide binding]; other site 718271000184 active site residues [active] 718271000185 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 718271000186 Hemerythrin family; Region: Hemerythrin-like; cl15774 718271000187 Hemerythrin; Region: Hemerythrin; cd12107 718271000188 Uncharacterized conserved protein [Function unknown]; Region: COG1556 718271000189 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 718271000190 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 718271000191 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718271000192 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 718271000193 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 718271000194 Cysteine-rich domain; Region: CCG; pfam02754 718271000195 Cysteine-rich domain; Region: CCG; pfam02754 718271000196 L-lactate permease; Region: Lactate_perm; cl00701 718271000197 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 718271000198 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 718271000199 CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081 718271000200 putative catalytic site [active] 718271000201 CdtC interface [polypeptide binding]; other site 718271000202 heterotrimer interface [polypeptide binding]; other site 718271000203 CdtA interface [polypeptide binding]; other site 718271000204 putative metal binding site [ion binding]; other site 718271000205 putative phosphate binding site [ion binding]; other site 718271000206 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 718271000207 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 718271000208 putative sugar binding sites [chemical binding]; other site 718271000209 Q-X-W motif; other site 718271000210 Cytochrome bd-type quinol oxidase, subunit 1 [Energy production and conversion]; Region: CydA; COG1271 718271000211 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 718271000212 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 718271000213 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 718271000214 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 718271000215 aspartate racemase; Region: asp_race; TIGR00035 718271000216 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 718271000217 ligand binding site [chemical binding]; other site 718271000218 active site 718271000219 UGI interface [polypeptide binding]; other site 718271000220 catalytic site [active] 718271000221 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 718271000222 Aspartase; Region: Aspartase; cd01357 718271000223 active sites [active] 718271000224 tetramer interface [polypeptide binding]; other site 718271000225 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 718271000226 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 718271000227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 718271000228 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 718271000229 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 718271000230 putative dimer interface [polypeptide binding]; other site 718271000231 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 718271000232 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 718271000233 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 718271000234 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 718271000235 GTPase CgtA; Reviewed; Region: obgE; PRK12299 718271000236 GTP1/OBG; Region: GTP1_OBG; pfam01018 718271000237 Obg GTPase; Region: Obg; cd01898 718271000238 G1 box; other site 718271000239 GTP/Mg2+ binding site [chemical binding]; other site 718271000240 Switch I region; other site 718271000241 G2 box; other site 718271000242 G3 box; other site 718271000243 Switch II region; other site 718271000244 G4 box; other site 718271000245 G5 box; other site 718271000246 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 718271000247 nucleotide binding site [chemical binding]; other site 718271000248 homotetrameric interface [polypeptide binding]; other site 718271000249 putative phosphate binding site [ion binding]; other site 718271000250 putative allosteric binding site; other site 718271000251 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 718271000252 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 718271000253 putative active site [active] 718271000254 substrate binding site [chemical binding]; other site 718271000255 putative cosubstrate binding site; other site 718271000256 catalytic site [active] 718271000257 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 718271000258 substrate binding site [chemical binding]; other site 718271000259 biotin--protein ligase; Provisional; Region: PRK08477 718271000260 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 718271000261 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 718271000262 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 718271000263 P-loop; other site 718271000264 Magnesium ion binding site [ion binding]; other site 718271000265 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 718271000266 Magnesium ion binding site [ion binding]; other site 718271000267 ParB-like nuclease domain; Region: ParB; smart00470 718271000268 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 718271000269 F0F1 ATP synthase subunit B'; Validated; Region: PRK08476 718271000270 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 718271000271 F0F1 ATP synthase subunit B; Validated; Region: PRK08475 718271000272 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 718271000273 F0F1 ATP synthase subunit delta; Validated; Region: PRK08474 718271000274 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 718271000275 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 718271000276 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 718271000277 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 718271000278 beta subunit interaction interface [polypeptide binding]; other site 718271000279 Walker A motif; other site 718271000280 ATP binding site [chemical binding]; other site 718271000281 Walker B motif; other site 718271000282 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 718271000283 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 718271000284 core domain interface [polypeptide binding]; other site 718271000285 delta subunit interface [polypeptide binding]; other site 718271000286 epsilon subunit interface [polypeptide binding]; other site 718271000287 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 718271000288 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 718271000289 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 718271000290 alpha subunit interaction interface [polypeptide binding]; other site 718271000291 Walker A motif; other site 718271000292 ATP binding site [chemical binding]; other site 718271000293 Walker B motif; other site 718271000294 inhibitor binding site; inhibition site 718271000295 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 718271000296 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 718271000297 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 718271000298 gamma subunit interface [polypeptide binding]; other site 718271000299 epsilon subunit interface [polypeptide binding]; other site 718271000300 LBP interface [polypeptide binding]; other site 718271000301 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 718271000302 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 718271000303 TolR protein; Region: tolR; TIGR02801 718271000304 TonB C terminal; Region: TonB_2; pfam13103 718271000305 translocation protein TolB; Provisional; Region: tolB; PRK04043 718271000306 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 718271000307 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718271000308 ligand binding site [chemical binding]; other site 718271000309 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 718271000310 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 718271000311 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 718271000312 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 718271000313 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 718271000314 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 718271000315 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 718271000316 Ligand Binding Site [chemical binding]; other site 718271000317 Isochorismatase family; Region: Isochorismatase; pfam00857 718271000318 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 718271000319 catalytic triad [active] 718271000320 conserved cis-peptide bond; other site 718271000321 putative recombination protein RecO; Provisional; Region: PRK13908 718271000322 metal-binding heat shock protein; Provisional; Region: PRK00016 718271000323 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 718271000324 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 718271000325 FMN binding site [chemical binding]; other site 718271000326 active site 718271000327 catalytic residues [active] 718271000328 substrate binding site [chemical binding]; other site 718271000329 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 718271000330 Uncharacterized conserved protein [Function unknown]; Region: COG1576 718271000331 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 718271000332 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 718271000333 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 718271000334 Putative fructose-1,6-bisphosphatase or related enzymes of inositol monophosphatase family. These are Mg++ dependent phosphatases. Members in this family may have fructose-1,6-bisphosphatase and/or inositol-monophosphatase activity. Fructose-1; Region: Arch_FBPase_2; cd01642 718271000335 putative active site [active] 718271000336 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 718271000337 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718271000338 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718271000339 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718271000340 Surface antigen; Region: Bac_surface_Ag; pfam01103 718271000341 prephenate dehydrogenase; Validated; Region: PRK08507 718271000342 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 718271000343 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 718271000344 Peptidase family M23; Region: Peptidase_M23; pfam01551 718271000345 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 718271000346 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 718271000347 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 718271000348 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 718271000349 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 718271000350 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 718271000351 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 718271000352 translation initiation factor IF-2; Region: IF-2; TIGR00487 718271000353 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 718271000354 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 718271000355 G1 box; other site 718271000356 putative GEF interaction site [polypeptide binding]; other site 718271000357 GTP/Mg2+ binding site [chemical binding]; other site 718271000358 Switch I region; other site 718271000359 G2 box; other site 718271000360 G3 box; other site 718271000361 Switch II region; other site 718271000362 G4 box; other site 718271000363 G5 box; other site 718271000364 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 718271000365 Translation-initiation factor 2; Region: IF-2; pfam11987 718271000366 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 718271000367 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 718271000368 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 718271000369 Sm and related proteins; Region: Sm_like; cl00259 718271000370 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 718271000371 putative oligomer interface [polypeptide binding]; other site 718271000372 putative RNA binding site [nucleotide binding]; other site 718271000373 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 718271000374 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 718271000375 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 718271000376 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718271000377 dimer interface [polypeptide binding]; other site 718271000378 putative PBP binding regions; other site 718271000379 ABC-ATPase subunit interface; other site 718271000380 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 718271000381 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 718271000382 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 718271000383 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 718271000384 putative metal binding residues [ion binding]; other site 718271000385 Cache domain; Region: Cache_1; pfam02743 718271000386 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 718271000387 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718271000388 dimer interface [polypeptide binding]; other site 718271000389 putative CheW interface [polypeptide binding]; other site 718271000390 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 718271000391 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 718271000392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 718271000393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718271000394 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 718271000395 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 718271000396 catalytic residues [active] 718271000397 Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792 718271000398 homoserine dehydrogenase; Provisional; Region: PRK06349 718271000399 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 718271000400 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 718271000401 aspartate aminotransferase; Provisional; Region: PRK08636 718271000402 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718271000403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271000404 homodimer interface [polypeptide binding]; other site 718271000405 catalytic residue [active] 718271000406 Helix-turn-helix domain; Region: HTH_25; pfam13413 718271000407 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 718271000408 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 718271000409 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 718271000410 Predicted methyltransferases [General function prediction only]; Region: COG0313 718271000411 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 718271000412 putative SAM binding site [chemical binding]; other site 718271000413 putative homodimer interface [polypeptide binding]; other site 718271000414 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 718271000415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 718271000416 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 718271000417 queuosine biosynthesis protein QueD; Region: queuosine_QueD; TIGR03367 718271000418 active site 718271000419 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 718271000420 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718271000421 FeS/SAM binding site; other site 718271000422 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 718271000423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718271000424 FeS/SAM binding site; other site 718271000425 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 718271000426 prenyltransferase; Reviewed; Region: ubiA; PRK12874 718271000427 UbiA prenyltransferase family; Region: UbiA; pfam01040 718271000428 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 718271000429 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 718271000430 Predicted membrane protein [Function unknown]; Region: COG1971 718271000431 Domain of unknown function DUF; Region: DUF204; pfam02659 718271000432 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 718271000433 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 718271000434 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 718271000435 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 718271000436 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 718271000437 NAD(P) binding pocket [chemical binding]; other site 718271000438 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 718271000439 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 718271000440 Walker A/P-loop; other site 718271000441 ATP binding site [chemical binding]; other site 718271000442 Q-loop/lid; other site 718271000443 ABC transporter signature motif; other site 718271000444 Walker B; other site 718271000445 D-loop; other site 718271000446 H-loop/switch region; other site 718271000447 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 718271000448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271000449 dimer interface [polypeptide binding]; other site 718271000450 conserved gate region; other site 718271000451 putative PBP binding loops; other site 718271000452 ABC-ATPase subunit interface; other site 718271000453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271000454 dimer interface [polypeptide binding]; other site 718271000455 conserved gate region; other site 718271000456 putative PBP binding loops; other site 718271000457 ABC-ATPase subunit interface; other site 718271000458 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 718271000459 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 718271000460 Uncharacterized iron-regulated protein [Function unknown]; Region: PhuW; COG3016 718271000461 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 718271000462 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 718271000463 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 718271000464 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 718271000465 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 718271000466 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 718271000467 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 718271000468 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 718271000469 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 718271000470 Domain of unknown function DUF21; Region: DUF21; pfam01595 718271000471 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 718271000472 Transporter associated domain; Region: CorC_HlyC; smart01091 718271000473 Predicted kinase [General function prediction only]; Region: COG4639 718271000474 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 718271000475 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 718271000476 active site 718271000477 metal binding site [ion binding]; metal-binding site 718271000478 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 718271000479 PhnA protein; Region: PhnA; pfam03831 718271000480 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 718271000481 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 718271000482 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 718271000483 active site 718271000484 substrate binding site [chemical binding]; other site 718271000485 cosubstrate binding site; other site 718271000486 catalytic site [active] 718271000487 Uncharacterized conserved protein [Function unknown]; Region: COG0062 718271000488 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 718271000489 putative substrate binding site [chemical binding]; other site 718271000490 putative ATP binding site [chemical binding]; other site 718271000491 Uncharacterized conserved protein [Function unknown]; Region: COG1432 718271000492 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 718271000493 putative metal binding site [ion binding]; other site 718271000494 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 718271000495 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 718271000496 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 718271000497 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 718271000498 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 718271000499 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 718271000500 active site 718271000501 catalytic residues [active] 718271000502 metal binding site [ion binding]; metal-binding site 718271000503 Clp protease; Region: CLP_protease; pfam00574 718271000504 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 718271000505 oligomer interface [polypeptide binding]; other site 718271000506 active site residues [active] 718271000507 trigger factor; Provisional; Region: tig; PRK01490 718271000508 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 718271000509 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 718271000510 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 718271000511 homodecamer interface [polypeptide binding]; other site 718271000512 GTP cyclohydrolase I; Provisional; Region: PLN03044 718271000513 active site 718271000514 putative catalytic site residues [active] 718271000515 zinc binding site [ion binding]; other site 718271000516 GTP-CH-I/GFRP interaction surface; other site 718271000517 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 718271000518 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 718271000519 Walker A motif/ATP binding site; other site 718271000520 Walker B motif; other site 718271000521 amidophosphoribosyltransferase; Provisional; Region: PRK08525 718271000522 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 718271000523 active site 718271000524 tetramer interface [polypeptide binding]; other site 718271000525 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718271000526 active site 718271000527 dihydrodipicolinate reductase; Provisional; Region: PRK00048 718271000528 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 718271000529 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 718271000530 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 718271000531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271000532 Walker A motif; other site 718271000533 ATP binding site [chemical binding]; other site 718271000534 Walker B motif; other site 718271000535 arginine finger; other site 718271000536 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 718271000537 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 718271000538 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 718271000539 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 718271000540 Citrate transporter; Region: CitMHS; pfam03600 718271000541 Predicted membrane protein [Function unknown]; Region: COG1297 718271000542 putative oligopeptide transporter, OPT family; Region: TIGR00733 718271000543 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 718271000544 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 718271000545 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 718271000546 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 718271000547 active site 718271000548 dimer interface [polypeptide binding]; other site 718271000549 motif 1; other site 718271000550 motif 2; other site 718271000551 motif 3; other site 718271000552 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 718271000553 anticodon binding site; other site 718271000554 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 718271000555 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 718271000556 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 718271000557 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 718271000558 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 718271000559 potential frameshift: common BLAST hit: gi|315123809|ref|YP_004065813.1| serine protease eatA precursor 718271000560 potential frameshift: common BLAST hit: gi|315123809|ref|YP_004065813.1| serine protease eatA precursor 718271000561 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 718271000562 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 718271000563 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 718271000564 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 718271000565 putative acetyltransferase YhhY; Provisional; Region: PRK10140 718271000566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718271000567 Coenzyme A binding pocket [chemical binding]; other site 718271000568 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 718271000569 feedback inhibition sensing region; other site 718271000570 homohexameric interface [polypeptide binding]; other site 718271000571 nucleotide binding site [chemical binding]; other site 718271000572 N-acetyl-L-glutamate binding site [chemical binding]; other site 718271000573 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 718271000574 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 718271000575 inhibitor-cofactor binding pocket; inhibition site 718271000576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271000577 catalytic residue [active] 718271000578 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 718271000579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718271000580 S-adenosylmethionine binding site [chemical binding]; other site 718271000581 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 718271000582 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 718271000583 trimer interface [polypeptide binding]; other site 718271000584 putative metal binding site [ion binding]; other site 718271000585 putative nicotinate phosphoribosyltransferase; Region: NAPRTase_put; TIGR01513 718271000586 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 718271000587 active site 718271000588 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 718271000589 dimer interface [polypeptide binding]; other site 718271000590 putative radical transfer pathway; other site 718271000591 diiron center [ion binding]; other site 718271000592 tyrosyl radical; other site 718271000593 RDD family; Region: RDD; pfam06271 718271000594 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718271000595 active site 718271000596 ribosome recycling factor; Reviewed; Region: frr; PRK00083 718271000597 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 718271000598 hinge region; other site 718271000599 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 718271000600 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 718271000601 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 718271000602 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 718271000603 active site clefts [active] 718271000604 zinc binding site [ion binding]; other site 718271000605 dimer interface [polypeptide binding]; other site 718271000606 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 718271000607 Mechanosensitive ion channel; Region: MS_channel; pfam00924 718271000608 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 718271000609 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 718271000610 trimerization site [polypeptide binding]; other site 718271000611 active site 718271000612 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 718271000613 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 718271000614 cysteine desulfurase, NifS family, epsilon proteobacteria type; Region: nifS_epsilon; TIGR03403 718271000615 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 718271000616 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718271000617 catalytic residue [active] 718271000618 Hemerythrin-like iron-binding protein 718271000619 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 718271000620 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 718271000621 23S rRNA binding site [nucleotide binding]; other site 718271000622 L21 binding site [polypeptide binding]; other site 718271000623 L13 binding site [polypeptide binding]; other site 718271000624 FIST C domain; Region: FIST_C; pfam10442 718271000625 hypothetical protein 718271000626 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 718271000627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271000628 metabolite-proton symporter; Region: 2A0106; TIGR00883 718271000629 putative substrate translocation pore; other site 718271000630 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 718271000631 trimer interface [polypeptide binding]; other site 718271000632 dimer interface [polypeptide binding]; other site 718271000633 putative active site [active] 718271000634 Protein of unknown function (DUF493); Region: DUF493; pfam04359 718271000635 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 718271000636 putative catalytic site [active] 718271000637 putative metal binding site [ion binding]; other site 718271000638 putative phosphate binding site [ion binding]; other site 718271000639 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 718271000640 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 718271000641 Sulfatase; Region: Sulfatase; pfam00884 718271000642 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 718271000643 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 718271000644 active site 718271000645 substrate binding pocket [chemical binding]; other site 718271000646 dimer interface [polypeptide binding]; other site 718271000647 D12 class N6 adenine-specific DNA methyltransferase, putative 718271000648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718271000649 S-adenosylmethionine binding site [chemical binding]; other site 718271000650 Cache domain; Region: Cache_1; pfam02743 718271000651 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 718271000652 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718271000653 dimer interface [polypeptide binding]; other site 718271000654 putative CheW interface [polypeptide binding]; other site 718271000655 zinc transporter ZupT; Provisional; Region: PRK04201 718271000656 ZIP Zinc transporter; Region: Zip; pfam02535 718271000657 Cache domain; Region: Cache_1; pfam02743 718271000658 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 718271000659 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718271000660 dimer interface [polypeptide binding]; other site 718271000661 putative CheW interface [polypeptide binding]; other site 718271000662 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 718271000663 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 718271000664 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 718271000665 SPFH domain / Band 7 family; Region: Band_7; pfam01145 718271000666 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 718271000667 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 718271000668 homodimer interface [polypeptide binding]; other site 718271000669 substrate-cofactor binding pocket; other site 718271000670 catalytic residue [active] 718271000671 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 718271000672 active site 1 [active] 718271000673 dimer interface [polypeptide binding]; other site 718271000674 hexamer interface [polypeptide binding]; other site 718271000675 active site 2 [active] 718271000676 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 718271000677 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 718271000678 catalytic triad [active] 718271000679 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 718271000680 Ligand Binding Site [chemical binding]; other site 718271000681 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 718271000682 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 718271000683 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 718271000684 active site 718271000685 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 718271000686 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 718271000687 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 718271000688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271000689 Walker A motif; other site 718271000690 ATP binding site [chemical binding]; other site 718271000691 Walker B motif; other site 718271000692 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 718271000693 rod shape-determining protein MreB; Provisional; Region: PRK13927 718271000694 MreB and similar proteins; Region: MreB_like; cd10225 718271000695 nucleotide binding site [chemical binding]; other site 718271000696 Mg binding site [ion binding]; other site 718271000697 putative protofilament interaction site [polypeptide binding]; other site 718271000698 RodZ interaction site [polypeptide binding]; other site 718271000699 rod shape-determining protein MreC; Provisional; Region: PRK13922 718271000700 rod shape-determining protein MreC; Region: MreC; pfam04085 718271000701 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 718271000702 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 718271000703 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 718271000704 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 718271000705 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 718271000706 ATP-grasp domain; Region: ATP-grasp_4; cl17255 718271000707 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 718271000708 IMP binding site; other site 718271000709 dimer interface [polypeptide binding]; other site 718271000710 interdomain contacts; other site 718271000711 partial ornithine binding site; other site 718271000712 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 718271000713 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 718271000714 putative active site [active] 718271000715 transaldolase; Provisional; Region: PRK03903 718271000716 catalytic residue [active] 718271000717 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 718271000718 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 718271000719 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718271000720 motif II; other site 718271000721 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 718271000722 putative CheA interaction surface; other site 718271000723 chemotaxis protein CheA; Provisional; Region: PRK10547 718271000724 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 718271000725 putative binding surface; other site 718271000726 active site 718271000727 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 718271000728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718271000729 ATP binding site [chemical binding]; other site 718271000730 Mg2+ binding site [ion binding]; other site 718271000731 G-X-G motif; other site 718271000732 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 718271000733 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 718271000734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718271000735 active site 718271000736 phosphorylation site [posttranslational modification] 718271000737 intermolecular recognition site; other site 718271000738 dimerization interface [polypeptide binding]; other site 718271000739 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 718271000740 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 718271000741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718271000742 active site 718271000743 phosphorylation site [posttranslational modification] 718271000744 intermolecular recognition site; other site 718271000745 dimerization interface [polypeptide binding]; other site 718271000746 active site 718271000747 metal binding site [ion binding]; metal-binding site 718271000748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2908 718271000749 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 718271000750 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 718271000751 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 718271000752 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 718271000753 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 718271000754 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 718271000755 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 718271000756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271000757 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 718271000758 putative substrate translocation pore; other site 718271000759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271000760 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 718271000761 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 718271000762 ATP binding site [chemical binding]; other site 718271000763 substrate interface [chemical binding]; other site 718271000764 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 718271000765 tetramerization interface [polypeptide binding]; other site 718271000766 active site 718271000767 pantoate--beta-alanine ligase; Region: panC; TIGR00018 718271000768 Pantoate-beta-alanine ligase; Region: PanC; cd00560 718271000769 active site 718271000770 ATP-binding site [chemical binding]; other site 718271000771 pantoate-binding site; other site 718271000772 HXXH motif; other site 718271000773 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 718271000774 oligomerization interface [polypeptide binding]; other site 718271000775 active site 718271000776 metal binding site [ion binding]; metal-binding site 718271000777 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 718271000778 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 718271000779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718271000780 Walker A/P-loop; other site 718271000781 ATP binding site [chemical binding]; other site 718271000782 Q-loop/lid; other site 718271000783 ABC transporter signature motif; other site 718271000784 Walker B; other site 718271000785 D-loop; other site 718271000786 H-loop/switch region; other site 718271000787 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 718271000788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271000789 dimer interface [polypeptide binding]; other site 718271000790 conserved gate region; other site 718271000791 putative PBP binding loops; other site 718271000792 ABC-ATPase subunit interface; other site 718271000793 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 718271000794 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 718271000795 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 718271000796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718271000797 S-adenosylmethionine binding site [chemical binding]; other site 718271000798 Protein of unknown function (DUF452); Region: DUF452; cl01062 718271000799 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 718271000800 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 718271000801 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718271000802 catalytic residue [active] 718271000803 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 718271000804 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 718271000805 inhibitor-cofactor binding pocket; inhibition site 718271000806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271000807 catalytic residue [active] 718271000808 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 718271000809 AAA domain; Region: AAA_26; pfam13500 718271000810 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 718271000811 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 718271000812 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 718271000813 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 718271000814 5S rRNA interface [nucleotide binding]; other site 718271000815 CTC domain interface [polypeptide binding]; other site 718271000816 L16 interface [polypeptide binding]; other site 718271000817 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 718271000818 putative active site [active] 718271000819 catalytic residue [active] 718271000820 Predicted permeases [General function prediction only]; Region: COG0795 718271000821 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 718271000822 diaminopimelate decarboxylase; Region: lysA; TIGR01048 718271000823 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 718271000824 active site 718271000825 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718271000826 substrate binding site [chemical binding]; other site 718271000827 catalytic residues [active] 718271000828 dimer interface [polypeptide binding]; other site 718271000829 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 718271000830 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718271000831 active site 718271000832 motif I; other site 718271000833 motif II; other site 718271000834 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 718271000835 chorismate mutase domain of proteobacterial P-protein, clade 2; Region: CM_P2; TIGR01807 718271000836 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 718271000837 Prephenate dehydratase; Region: PDT; pfam00800 718271000838 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 718271000839 putative L-Phe binding site [chemical binding]; other site 718271000840 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 718271000841 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718271000842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271000843 homodimer interface [polypeptide binding]; other site 718271000844 catalytic residue [active] 718271000845 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 718271000846 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 718271000847 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 718271000848 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 718271000849 FliG C-terminal domain; Region: FliG_C; pfam01706 718271000850 flagellar assembly protein H; Validated; Region: fliH; PRK06669 718271000851 Flagellar assembly protein FliH; Region: FliH; pfam02108 718271000852 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 718271000853 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 718271000854 TPP-binding site; other site 718271000855 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 718271000856 PYR/PP interface [polypeptide binding]; other site 718271000857 dimer interface [polypeptide binding]; other site 718271000858 TPP binding site [chemical binding]; other site 718271000859 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 718271000860 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 718271000861 metal binding site 2 [ion binding]; metal-binding site 718271000862 putative DNA binding helix; other site 718271000863 metal binding site 1 [ion binding]; metal-binding site 718271000864 structural Zn2+ binding site [ion binding]; other site 718271000865 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 718271000866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718271000867 S-adenosylmethionine binding site [chemical binding]; other site 718271000868 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 718271000869 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 718271000870 generic binding surface II; other site 718271000871 generic binding surface I; other site 718271000872 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 718271000873 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 718271000874 homodimer interface [polypeptide binding]; other site 718271000875 substrate-cofactor binding pocket; other site 718271000876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271000877 catalytic residue [active] 718271000878 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 718271000879 homotrimer interaction site [polypeptide binding]; other site 718271000880 putative active site [active] 718271000881 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 718271000882 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 718271000883 dimer interface [polypeptide binding]; other site 718271000884 active site 718271000885 CoA binding pocket [chemical binding]; other site 718271000886 putative phosphate acyltransferase; Provisional; Region: PRK05331 718271000887 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 718271000888 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 718271000889 active site 718271000890 multimer interface [polypeptide binding]; other site 718271000891 Ferredoxin [Energy production and conversion]; Region: COG1146 718271000892 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 718271000893 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 718271000894 dimer interface [polypeptide binding]; other site 718271000895 decamer (pentamer of dimers) interface [polypeptide binding]; other site 718271000896 catalytic triad [active] 718271000897 peroxidatic and resolving cysteines [active] 718271000898 Flagellar biosynthesis protein FlhB;truncated protein 718271000899 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 718271000900 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 718271000901 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718271000902 ligand binding site [chemical binding]; other site 718271000903 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 718271000904 flagellar motor protein MotA; Validated; Region: PRK08456 718271000905 DNA polymerase I; Provisional; Region: PRK05755 718271000906 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 718271000907 active site 718271000908 metal binding site 1 [ion binding]; metal-binding site 718271000909 putative 5' ssDNA interaction site; other site 718271000910 metal binding site 3; metal-binding site 718271000911 metal binding site 2 [ion binding]; metal-binding site 718271000912 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 718271000913 putative DNA binding site [nucleotide binding]; other site 718271000914 putative metal binding site [ion binding]; other site 718271000915 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 718271000916 active site 718271000917 catalytic site [active] 718271000918 substrate binding site [chemical binding]; other site 718271000919 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 718271000920 active site 718271000921 DNA binding site [nucleotide binding] 718271000922 catalytic site [active] 718271000923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271000924 metabolite-proton symporter; Region: 2A0106; TIGR00883 718271000925 putative substrate translocation pore; other site 718271000926 nuc_hydro_CjNH. Nucleoside hydrolases similar to Campylobacter jejuni nucleoside hydrolase. This group contains eukaryotic and bacterial proteins similar to C. jejuni nucleoside hydrolase. Nucleoside hydrolases cleave the N-glycosidic bond in...; Region: nuc_hydro_CjNH; cd02654 718271000927 active site 718271000928 Predicted membrane protein [Function unknown]; Region: COG1238 718271000929 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Region: 2A060605; TIGR00920 718271000930 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 718271000931 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 718271000932 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 718271000933 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 718271000934 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 718271000935 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 718271000936 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 718271000937 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 718271000938 Glutamine amidotransferase class-I; Region: GATase; pfam00117 718271000939 glutamine binding [chemical binding]; other site 718271000940 catalytic triad [active] 718271000941 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 718271000942 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 718271000943 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 718271000944 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 718271000945 active site 718271000946 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 718271000947 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 718271000948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271000949 catalytic residue [active] 718271000950 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 718271000951 substrate binding site [chemical binding]; other site 718271000952 active site 718271000953 catalytic residues [active] 718271000954 heterodimer interface [polypeptide binding]; other site 718271000955 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 718271000956 flagellar motor switch protein; Validated; Region: PRK08433 718271000957 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 718271000958 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 718271000959 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 718271000960 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 718271000961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718271000962 active site 718271000963 phosphorylation site [posttranslational modification] 718271000964 intermolecular recognition site; other site 718271000965 dimerization interface [polypeptide binding]; other site 718271000966 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718271000967 DNA binding site [nucleotide binding] 718271000968 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 718271000969 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 718271000970 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 718271000971 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 718271000972 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 718271000973 active site 718271000974 substrate binding site [chemical binding]; other site 718271000975 metal binding site [ion binding]; metal-binding site 718271000976 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 718271000977 lipoprotein signal peptidase; Provisional; Region: PRK14787 718271000978 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 718271000979 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 718271000980 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 718271000981 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 718271000982 Protein export membrane protein; Region: SecD_SecF; cl14618 718271000983 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 718271000984 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718271000985 HlyD family secretion protein; Region: HlyD_3; pfam13437 718271000986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 718271000987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718271000988 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 718271000989 4Fe-4S binding domain; Region: Fer4_5; pfam12801 718271000990 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718271000991 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 718271000992 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 718271000993 hypothetical protein; Provisional; Region: PRK04081 718271000994 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 718271000995 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 718271000996 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 718271000997 putative ligand binding site [chemical binding]; other site 718271000998 putative NAD binding site [chemical binding]; other site 718271000999 catalytic site [active] 718271001000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 718271001001 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 718271001002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 718271001003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271001004 Walker A motif; other site 718271001005 ATP binding site [chemical binding]; other site 718271001006 Walker B motif; other site 718271001007 arginine finger; other site 718271001008 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 718271001009 TMAO/DMSO reductase; Reviewed; Region: PRK05363 718271001010 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 718271001011 Moco binding site; other site 718271001012 metal coordination site [ion binding]; other site 718271001013 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 718271001014 active site 718271001015 dimer interface [polypeptide binding]; other site 718271001016 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 718271001017 putative RNA binding site [nucleotide binding]; other site 718271001018 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 718271001019 homopentamer interface [polypeptide binding]; other site 718271001020 active site 718271001021 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 718271001022 EamA-like transporter family; Region: EamA; pfam00892 718271001023 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 718271001024 GTP-binding protein Der; Reviewed; Region: PRK00093 718271001025 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 718271001026 G1 box; other site 718271001027 GTP/Mg2+ binding site [chemical binding]; other site 718271001028 Switch I region; other site 718271001029 G2 box; other site 718271001030 Switch II region; other site 718271001031 G3 box; other site 718271001032 G4 box; other site 718271001033 G5 box; other site 718271001034 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 718271001035 GTP/Mg2+ binding site [chemical binding]; other site 718271001036 Switch I region; other site 718271001037 G2 box; other site 718271001038 G3 box; other site 718271001039 Switch II region; other site 718271001040 G4 box; other site 718271001041 G5 box; other site 718271001042 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 718271001043 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 718271001044 ADP binding site [chemical binding]; other site 718271001045 magnesium binding site [ion binding]; other site 718271001046 putative shikimate binding site; other site 718271001047 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 718271001048 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 718271001049 active site 718271001050 HIGH motif; other site 718271001051 dimer interface [polypeptide binding]; other site 718271001052 KMSKS motif; other site 718271001053 seryl-tRNA synthetase; Provisional; Region: PRK05431 718271001054 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 718271001055 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 718271001056 dimer interface [polypeptide binding]; other site 718271001057 active site 718271001058 motif 1; other site 718271001059 motif 2; other site 718271001060 motif 3; other site 718271001061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718271001062 binding surface 718271001063 TPR motif; other site 718271001064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718271001065 TPR motif; other site 718271001066 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 718271001067 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 718271001068 domain interfaces; other site 718271001069 active site 718271001070 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 718271001071 Predicted dehydrogenase [General function prediction only]; Region: COG0579 718271001072 pantothenate kinase; Reviewed; Region: PRK13333 718271001073 PQQ-like domain; Region: PQQ_2; pfam13360 718271001074 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 718271001075 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 718271001076 Colicin V production protein; Region: Colicin_V; pfam02674 718271001077 ferric uptake regulator; Provisional; Region: fur; PRK09462 718271001078 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 718271001079 metal binding site 2 [ion binding]; metal-binding site 718271001080 putative DNA binding helix; other site 718271001081 metal binding site 1 [ion binding]; metal-binding site 718271001082 dimer interface [polypeptide binding]; other site 718271001083 structural Zn2+ binding site [ion binding]; other site 718271001084 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 718271001085 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 718271001086 dimer interface [polypeptide binding]; other site 718271001087 putative anticodon binding site; other site 718271001088 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 718271001089 motif 1; other site 718271001090 active site 718271001091 motif 2; other site 718271001092 motif 3; other site 718271001093 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 718271001094 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 718271001095 dimer interface [polypeptide binding]; other site 718271001096 active site 718271001097 glycine-pyridoxal phosphate binding site [chemical binding]; other site 718271001098 folate binding site [chemical binding]; other site 718271001099 Domain of unknown function (DUF1882); Region: DUF1882; pfam08966 718271001100 Sporulation related domain; Region: SPOR; pfam05036 718271001101 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 718271001102 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 718271001103 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 718271001104 shikimate binding site; other site 718271001105 NAD(P) binding site [chemical binding]; other site 718271001106 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 718271001107 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553 718271001108 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 718271001109 Iron-sulfur protein interface; other site 718271001110 proximal heme binding site [chemical binding]; other site 718271001111 distal heme binding site [chemical binding]; other site 718271001112 dimer interface [polypeptide binding]; other site 718271001113 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 718271001114 L-aspartate oxidase; Provisional; Region: PRK06175 718271001115 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 718271001116 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 718271001117 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 718271001118 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718271001119 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 718271001120 Dynamin family; Region: Dynamin_N; pfam00350 718271001121 G1 box; other site 718271001122 GTP/Mg2+ binding site [chemical binding]; other site 718271001123 G2 box; other site 718271001124 Switch I region; other site 718271001125 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 718271001126 G3 box; other site 718271001127 Switch II region; other site 718271001128 GTP/Mg2+ binding site [chemical binding]; other site 718271001129 G4 box; other site 718271001130 G5 box; other site 718271001131 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 718271001132 Dynamin family; Region: Dynamin_N; pfam00350 718271001133 G1 box; other site 718271001134 GTP/Mg2+ binding site [chemical binding]; other site 718271001135 G2 box; other site 718271001136 Switch I region; other site 718271001137 G3 box; other site 718271001138 Switch II region; other site 718271001139 G4 box; other site 718271001140 G5 box; other site 718271001141 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 718271001142 Sel1-like repeats; Region: SEL1; smart00671 718271001143 Sel1 repeat; Region: Sel1; cl02723 718271001144 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 718271001145 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 718271001146 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 718271001147 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 718271001148 SprA-related family; Region: SprA-related; pfam12118 718271001149 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 718271001150 HIT family signature motif; other site 718271001151 catalytic residue [active] 718271001152 Uncharacterized conserved protein [Function unknown]; Region: COG2353 718271001153 Transposase; Region: HTH_Tnp_1; cl17663 718271001154 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 718271001155 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718271001156 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718271001157 ABC transporter; Region: ABC_tran_2; pfam12848 718271001158 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718271001159 S-layer like family, C-terminal region; Region: S_layer_C; pfam05124 718271001160 Uncharacterized conserved protein [Function unknown]; Region: COG1739 718271001161 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 718271001162 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 718271001163 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718271001164 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718271001165 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 718271001166 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 718271001167 Mg++ binding site [ion binding]; other site 718271001168 putative catalytic motif [active] 718271001169 putative substrate binding site [chemical binding]; other site 718271001170 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 718271001171 phosphoglyceromutase; Provisional; Region: PRK05434 718271001172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718271001173 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 718271001174 NAD(P) binding site [chemical binding]; other site 718271001175 active site 718271001176 Uncharacterized conserved protein [Function unknown]; Region: COG5015 718271001177 L-aspartate oxidase; Provisional; Region: PRK06175 718271001178 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 718271001179 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 718271001180 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 718271001181 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 718271001182 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 718271001183 Cysteine-rich domain; Region: CCG; pfam02754 718271001184 Cysteine-rich domain; Region: CCG; pfam02754 718271001185 Putative transcription activator [Transcription]; Region: TenA; COG0819 718271001186 acyl carrier protein; Provisional; Region: acpP; PRK00982 718271001187 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 718271001188 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 718271001189 dimer interface [polypeptide binding]; other site 718271001190 active site 718271001191 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 718271001192 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 718271001193 Ferric receptor CfrA 718271001194 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 718271001195 dimer interface [polypeptide binding]; other site 718271001196 ADP-ribose binding site [chemical binding]; other site 718271001197 active site 718271001198 nudix motif; other site 718271001199 metal binding site [ion binding]; metal-binding site 718271001200 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 718271001201 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718271001202 dimer interface [polypeptide binding]; other site 718271001203 putative CheW interface [polypeptide binding]; other site 718271001204 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 718271001205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 718271001206 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 718271001207 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 718271001208 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 718271001209 substrate binding site [chemical binding]; other site 718271001210 hexamer interface [polypeptide binding]; other site 718271001211 metal binding site [ion binding]; metal-binding site 718271001212 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 718271001213 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 718271001214 active site 718271001215 catalytic site [active] 718271001216 substrate binding site [chemical binding]; other site 718271001217 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 718271001218 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 718271001219 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 718271001220 putative acyl-acceptor binding pocket; other site 718271001221 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 718271001222 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 718271001223 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718271001224 FeS/SAM binding site; other site 718271001225 TRAM domain; Region: TRAM; pfam01938 718271001226 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 718271001227 NusA N-terminal domain; Region: NusA_N; pfam08529 718271001228 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 718271001229 RNA binding site [nucleotide binding]; other site 718271001230 homodimer interface [polypeptide binding]; other site 718271001231 NusA-like KH domain; Region: KH_5; pfam13184 718271001232 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 718271001233 G-X-X-G motif; other site 718271001234 H+ Antiporter protein; Region: 2A0121; TIGR00900 718271001235 hypothetical protein; Provisional; Region: PRK08445 718271001236 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718271001237 FeS/SAM binding site; other site 718271001238 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 718271001239 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 718271001240 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 718271001241 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 718271001242 generic binding surface II; other site 718271001243 ssDNA binding site; other site 718271001244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718271001245 ATP binding site [chemical binding]; other site 718271001246 putative Mg++ binding site [ion binding]; other site 718271001247 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718271001248 nucleotide binding region [chemical binding]; other site 718271001249 ATP-binding site [chemical binding]; other site 718271001250 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 718271001251 apolar tunnel; other site 718271001252 heme binding site [chemical binding]; other site 718271001253 dimerization interface [polypeptide binding]; other site 718271001254 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 718271001255 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 718271001256 ligand binding site [chemical binding]; other site 718271001257 flexible hinge region; other site 718271001258 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 718271001259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271001260 dimer interface [polypeptide binding]; other site 718271001261 conserved gate region; other site 718271001262 putative PBP binding loops; other site 718271001263 ABC-ATPase subunit interface; other site 718271001264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271001265 dimer interface [polypeptide binding]; other site 718271001266 conserved gate region; other site 718271001267 putative PBP binding loops; other site 718271001268 ABC-ATPase subunit interface; other site 718271001269 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 718271001270 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 718271001271 Walker A/P-loop; other site 718271001272 ATP binding site [chemical binding]; other site 718271001273 Q-loop/lid; other site 718271001274 ABC transporter signature motif; other site 718271001275 Walker B; other site 718271001276 D-loop; other site 718271001277 H-loop/switch region; other site 718271001278 elongation factor Tu; Reviewed; Region: PRK00049 718271001279 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 718271001280 G1 box; other site 718271001281 GEF interaction site [polypeptide binding]; other site 718271001282 GTP/Mg2+ binding site [chemical binding]; other site 718271001283 Switch I region; other site 718271001284 G2 box; other site 718271001285 G3 box; other site 718271001286 Switch II region; other site 718271001287 G4 box; other site 718271001288 G5 box; other site 718271001289 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 718271001290 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 718271001291 Antibiotic Binding Site [chemical binding]; other site 718271001292 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 718271001293 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 718271001294 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 718271001295 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 718271001296 putative homodimer interface [polypeptide binding]; other site 718271001297 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 718271001298 heterodimer interface [polypeptide binding]; other site 718271001299 homodimer interface [polypeptide binding]; other site 718271001300 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 718271001301 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 718271001302 23S rRNA interface [nucleotide binding]; other site 718271001303 L7/L12 interface [polypeptide binding]; other site 718271001304 putative thiostrepton binding site; other site 718271001305 L25 interface [polypeptide binding]; other site 718271001306 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 718271001307 mRNA/rRNA interface [nucleotide binding]; other site 718271001308 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 718271001309 23S rRNA interface [nucleotide binding]; other site 718271001310 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 718271001311 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 718271001312 L11 interface [polypeptide binding]; other site 718271001313 putative EF-Tu interaction site [polypeptide binding]; other site 718271001314 putative EF-G interaction site [polypeptide binding]; other site 718271001315 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 718271001316 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 718271001317 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 718271001318 RPB11 interaction site [polypeptide binding]; other site 718271001319 RPB12 interaction site [polypeptide binding]; other site 718271001320 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 718271001321 RPB3 interaction site [polypeptide binding]; other site 718271001322 RPB1 interaction site [polypeptide binding]; other site 718271001323 RPB11 interaction site [polypeptide binding]; other site 718271001324 RPB10 interaction site [polypeptide binding]; other site 718271001325 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 718271001326 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 718271001327 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 718271001328 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 718271001329 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 718271001330 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 718271001331 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 718271001332 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 718271001333 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 718271001334 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 718271001335 DNA binding site [nucleotide binding] 718271001336 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 718271001337 Transcriptional regulator [Transcription]; Region: IclR; COG1414 718271001338 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718271001339 putative DNA binding site [nucleotide binding]; other site 718271001340 putative Zn2+ binding site [ion binding]; other site 718271001341 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 718271001342 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 718271001343 inhibitor site; inhibition site 718271001344 active site 718271001345 dimer interface [polypeptide binding]; other site 718271001346 catalytic residue [active] 718271001347 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 718271001348 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 718271001349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271001350 putative substrate translocation pore; other site 718271001351 short chain dehydrogenase; Provisional; Region: PRK08628 718271001352 classical (c) SDRs; Region: SDR_c; cd05233 718271001353 NAD(P) binding site [chemical binding]; other site 718271001354 active site 718271001355 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 718271001356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271001357 putative substrate translocation pore; other site 718271001358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271001359 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 718271001360 Amidohydrolase; Region: Amidohydro_2; pfam04909 718271001361 Domain of unknown function (DUF718); Region: DUF718; cl01281 718271001362 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 718271001363 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 718271001364 NAD binding site [chemical binding]; other site 718271001365 catalytic residues [active] 718271001366 substrate binding site [chemical binding]; other site 718271001367 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 718271001368 S17 interaction site [polypeptide binding]; other site 718271001369 S8 interaction site; other site 718271001370 16S rRNA interaction site [nucleotide binding]; other site 718271001371 streptomycin interaction site [chemical binding]; other site 718271001372 23S rRNA interaction site [nucleotide binding]; other site 718271001373 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 718271001374 30S ribosomal protein S7; Validated; Region: PRK05302 718271001375 elongation factor G; Reviewed; Region: PRK00007 718271001376 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 718271001377 G1 box; other site 718271001378 putative GEF interaction site [polypeptide binding]; other site 718271001379 GTP/Mg2+ binding site [chemical binding]; other site 718271001380 Switch I region; other site 718271001381 G2 box; other site 718271001382 G3 box; other site 718271001383 Switch II region; other site 718271001384 G4 box; other site 718271001385 G5 box; other site 718271001386 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 718271001387 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 718271001388 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 718271001389 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 718271001390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718271001391 S-adenosylmethionine binding site [chemical binding]; other site 718271001392 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 718271001393 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 718271001394 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 718271001395 active site 718271001396 substrate (anthranilate) binding pocket [chemical binding]; other site 718271001397 product (indole) binding pocket [chemical binding]; other site 718271001398 ribulose/triose binding site [chemical binding]; other site 718271001399 phosphate binding site [ion binding]; other site 718271001400 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 718271001401 nucleotide binding site/active site [active] 718271001402 HIT family signature motif; other site 718271001403 catalytic residue [active] 718271001404 Predicted ATPase [General function prediction only]; Region: COG2603 718271001405 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 718271001406 active site residue [active] 718271001407 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 718271001408 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 718271001409 ferrochelatase; Reviewed; Region: hemH; PRK00035 718271001410 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 718271001411 C-terminal domain interface [polypeptide binding]; other site 718271001412 active site 718271001413 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 718271001414 active site 718271001415 N-terminal domain interface [polypeptide binding]; other site 718271001416 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 718271001417 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 718271001418 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 718271001419 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 718271001420 inhibitor-cofactor binding pocket; inhibition site 718271001421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271001422 catalytic residue [active] 718271001423 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 718271001424 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 718271001425 motif 1; other site 718271001426 active site 718271001427 motif 2; other site 718271001428 motif 3; other site 718271001429 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 718271001430 DHHA1 domain; Region: DHHA1; pfam02272 718271001431 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 718271001432 Maf-like protein; Region: Maf; pfam02545 718271001433 active site 718271001434 dimer interface [polypeptide binding]; other site 718271001435 Transglycosylase; Region: Transgly; pfam00912 718271001436 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 718271001437 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 718271001438 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 718271001439 Clp amino terminal domain; Region: Clp_N; pfam02861 718271001440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271001441 Walker A motif; other site 718271001442 ATP binding site [chemical binding]; other site 718271001443 Walker B motif; other site 718271001444 arginine finger; other site 718271001445 Protein of unknown function (DUF972); Region: DUF972; pfam06156 718271001446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271001447 Walker A motif; other site 718271001448 ATP binding site [chemical binding]; other site 718271001449 Walker B motif; other site 718271001450 arginine finger; other site 718271001451 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 718271001452 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 718271001453 putative homodimer interface [polypeptide binding]; other site 718271001454 putative homotetramer interface [polypeptide binding]; other site 718271001455 putative metal binding site [ion binding]; other site 718271001456 putative homodimer-homodimer interface [polypeptide binding]; other site 718271001457 putative allosteric switch controlling residues; other site 718271001458 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 718271001459 C-terminal peptidase (prc); Region: prc; TIGR00225 718271001460 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 718271001461 protein binding site [polypeptide binding]; other site 718271001462 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 718271001463 Catalytic dyad [active] 718271001464 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 718271001465 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 718271001466 ATP binding site [chemical binding]; other site 718271001467 active site 718271001468 substrate binding site [chemical binding]; other site 718271001469 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 718271001470 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 718271001471 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 718271001472 putative active site [active] 718271001473 catalytic triad [active] 718271001474 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 718271001475 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 718271001476 putative acyl-acceptor binding pocket; other site 718271001477 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 718271001478 heat shock protein 90; Provisional; Region: PRK05218 718271001479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718271001480 ATP binding site [chemical binding]; other site 718271001481 Mg2+ binding site [ion binding]; other site 718271001482 G-X-G motif; other site 718271001483 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 718271001484 active site residue [active] 718271001485 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 718271001486 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 718271001487 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 718271001488 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 718271001489 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 718271001490 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 718271001491 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK03907 718271001492 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 718271001493 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718271001494 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718271001495 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 718271001496 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 718271001497 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 718271001498 dimerization interface [polypeptide binding]; other site 718271001499 Protein of unknown function; Region: DUF3971; pfam13116 718271001500 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 718271001501 AsmA-like C-terminal region; Region: AsmA_1; pfam13109 718271001502 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 718271001503 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 718271001504 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 718271001505 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 718271001506 NAD(P) binding site [chemical binding]; other site 718271001507 LDH/MDH dimer interface [polypeptide binding]; other site 718271001508 substrate binding site [chemical binding]; other site 718271001509 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 718271001510 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 718271001511 CoA-ligase; Region: Ligase_CoA; pfam00549 718271001512 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 718271001513 CoA binding domain; Region: CoA_binding; smart00881 718271001514 CoA-ligase; Region: Ligase_CoA; pfam00549 718271001515 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 718271001516 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 718271001517 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 718271001518 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 718271001519 dimer interface [polypeptide binding]; other site 718271001520 PYR/PP interface [polypeptide binding]; other site 718271001521 TPP binding site [chemical binding]; other site 718271001522 substrate binding site [chemical binding]; other site 718271001523 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 718271001524 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 718271001525 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 718271001526 TPP-binding site [chemical binding]; other site 718271001527 2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441 718271001528 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 718271001529 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 718271001530 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 718271001531 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 718271001532 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 718271001533 substrate binding pocket [chemical binding]; other site 718271001534 chain length determination region; other site 718271001535 substrate-Mg2+ binding site; other site 718271001536 catalytic residues [active] 718271001537 aspartate-rich region 1; other site 718271001538 active site lid residues [active] 718271001539 aspartate-rich region 2; other site 718271001540 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 718271001541 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 718271001542 tRNA; other site 718271001543 putative tRNA binding site [nucleotide binding]; other site 718271001544 putative NADP binding site [chemical binding]; other site 718271001545 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 718271001546 prolyl-tRNA synthetase; Provisional; Region: PRK09194 718271001547 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 718271001548 dimer interface [polypeptide binding]; other site 718271001549 motif 1; other site 718271001550 active site 718271001551 motif 2; other site 718271001552 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 718271001553 putative deacylase active site [active] 718271001554 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 718271001555 active site 718271001556 motif 3; other site 718271001557 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 718271001558 anticodon binding site; other site 718271001559 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 718271001560 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 718271001561 domain interfaces; other site 718271001562 active site 718271001563 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 718271001564 FlaG protein; Region: FlaG; cl00591 718271001565 flagellar capping protein; Provisional; Region: PRK12765 718271001566 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 718271001567 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 718271001568 flagellar protein FliS; Validated; Region: fliS; PRK05685 718271001569 elongation factor P; Validated; Region: PRK00529 718271001570 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 718271001571 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 718271001572 RNA binding site [nucleotide binding]; other site 718271001573 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 718271001574 RNA binding site [nucleotide binding]; other site 718271001575 Predicted membrane protein [Function unknown]; Region: COG3819 718271001576 Predicted membrane protein [Function unknown]; Region: COG3817 718271001577 Protein of unknown function (DUF979); Region: DUF979; pfam06166 718271001578 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 718271001579 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 718271001580 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 718271001581 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 718271001582 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 718271001583 active site 718271001584 Predicted membrane protein [Function unknown]; Region: COG1289 718271001585 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 718271001586 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 718271001587 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 718271001588 putative catalytic cysteine [active] 718271001589 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 718271001590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 718271001591 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718271001592 MATE efflux family protein 718271001593 Protein of unknown function (DUF2860); Region: DUF2860; pfam11059 718271001594 replicative DNA helicase; Provisional; Region: PRK08506 718271001595 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 718271001596 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 718271001597 Walker A motif; other site 718271001598 ATP binding site [chemical binding]; other site 718271001599 Walker B motif; other site 718271001600 DNA binding loops [nucleotide binding] 718271001601 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 718271001602 G1 box; other site 718271001603 GTP/Mg2+ binding site [chemical binding]; other site 718271001604 G2 box; other site 718271001605 Switch I region; other site 718271001606 G3 box; other site 718271001607 Switch II region; other site 718271001608 G4 box; other site 718271001609 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 718271001610 putative ATP 718271001611 Predicted transcriptional regulator [Transcription]; Region: COG2378 718271001612 HTH domain; Region: HTH_11; pfam08279 718271001613 WYL domain; Region: WYL; pfam13280 718271001614 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 718271001615 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 718271001616 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 718271001617 Uncharacterized conserved protein [Function unknown]; Region: COG1610 718271001618 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527 718271001619 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 718271001620 PYR/PP interface [polypeptide binding]; other site 718271001621 dimer interface [polypeptide binding]; other site 718271001622 TPP binding site [chemical binding]; other site 718271001623 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 718271001624 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 718271001625 TPP-binding site [chemical binding]; other site 718271001626 dimer interface [polypeptide binding]; other site 718271001627 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 718271001628 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 718271001629 putative valine binding site [chemical binding]; other site 718271001630 dimer interface [polypeptide binding]; other site 718271001631 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 718271001632 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 718271001633 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 718271001634 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 718271001635 trimer interface [polypeptide binding]; other site 718271001636 active site 718271001637 UDP-GlcNAc binding site [chemical binding]; other site 718271001638 lipid binding site [chemical binding]; lipid-binding site 718271001639 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 718271001640 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 718271001641 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 718271001642 sec-independent translocase; Provisional; Region: PRK04098 718271001643 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 718271001644 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 718271001645 putative active site [active] 718271001646 Ap4A binding site [chemical binding]; other site 718271001647 nudix motif; other site 718271001648 putative metal binding site [ion binding]; other site 718271001649 aspartate kinase; Reviewed; Region: PRK06635 718271001650 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 718271001651 putative nucleotide binding site [chemical binding]; other site 718271001652 putative catalytic residues [active] 718271001653 putative Mg ion binding site [ion binding]; other site 718271001654 putative aspartate binding site [chemical binding]; other site 718271001655 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 718271001656 putative allosteric regulatory site; other site 718271001657 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 718271001658 DNA replication regulator; Region: HobA; pfam12163 718271001659 DNA polymerase III subunit delta'; Validated; Region: PRK08485 718271001660 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 718271001661 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 718271001662 substrate binding pocket [chemical binding]; other site 718271001663 dimer interface [polypeptide binding]; other site 718271001664 inhibitor binding site; inhibition site 718271001665 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 718271001666 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 718271001667 nucleotide binding pocket [chemical binding]; other site 718271001668 K-X-D-G motif; other site 718271001669 catalytic site [active] 718271001670 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 718271001671 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 718271001672 Dimer interface [polypeptide binding]; other site 718271001673 BRCT sequence motif; other site 718271001674 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 718271001675 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 718271001676 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 718271001677 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 718271001678 active site 718271001679 nucleotide binding site [chemical binding]; other site 718271001680 HIGH motif; other site 718271001681 KMSKS motif; other site 718271001682 Riboflavin kinase; Region: Flavokinase; pfam01687 718271001683 Methyltransferase domain; Region: Methyltransf_31; pfam13847 718271001684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718271001685 S-adenosylmethionine binding site [chemical binding]; other site 718271001686 Predicted membrane protein [Function unknown]; Region: COG2860 718271001687 UPF0126 domain; Region: UPF0126; pfam03458 718271001688 UPF0126 domain; Region: UPF0126; pfam03458 718271001689 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 718271001690 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 718271001691 active site 718271001692 substrate binding site [chemical binding]; other site 718271001693 Mg2+ binding site [ion binding]; other site 718271001694 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 718271001695 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 718271001696 minor groove reading motif; other site 718271001697 helix-hairpin-helix signature motif; other site 718271001698 substrate binding pocket [chemical binding]; other site 718271001699 active site 718271001700 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 718271001701 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 718271001702 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 718271001703 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 718271001704 active site 718271001705 intersubunit interface [polypeptide binding]; other site 718271001706 zinc binding site [ion binding]; other site 718271001707 Na+ binding site [ion binding]; other site 718271001708 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 718271001709 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 718271001710 hypothetical protein; Validated; Region: PRK09039 718271001711 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718271001712 ligand binding site [chemical binding]; other site 718271001713 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 718271001714 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 718271001715 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718271001716 catalytic residue [active] 718271001717 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 718271001718 Na2 binding site [ion binding]; other site 718271001719 putative substrate binding site 1 [chemical binding]; other site 718271001720 Na binding site 1 [ion binding]; other site 718271001721 putative substrate binding site 2 [chemical binding]; other site 718271001722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 718271001723 MOSC domain; Region: MOSC; pfam03473 718271001724 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 718271001725 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 718271001726 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 718271001727 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 718271001728 DsbD alpha interface [polypeptide binding]; other site 718271001729 catalytic residues [active] 718271001730 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 718271001731 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 718271001732 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 718271001733 metal binding site [ion binding]; metal-binding site 718271001734 dimer interface [polypeptide binding]; other site 718271001735 macrolide transporter subunit MacA; Provisional; Region: PRK11578 718271001736 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718271001737 HlyD family secretion protein; Region: HlyD_3; pfam13437 718271001738 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 718271001739 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 718271001740 Walker A/P-loop; other site 718271001741 ATP binding site [chemical binding]; other site 718271001742 Q-loop/lid; other site 718271001743 ABC transporter signature motif; other site 718271001744 Walker B; other site 718271001745 D-loop; other site 718271001746 H-loop/switch region; other site 718271001747 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 718271001748 FtsX-like permease family; Region: FtsX; pfam02687 718271001749 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 718271001750 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 718271001751 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 718271001752 active site 718271001753 oxyanion hole [active] 718271001754 catalytic triad [active] 718271001755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2845 718271001756 active site 718271001757 catalytic triad [active] 718271001758 oxyanion hole [active] 718271001759 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 718271001760 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 718271001761 Ferritin-like domain; Region: Ferritin; pfam00210 718271001762 ferroxidase diiron center [ion binding]; other site 718271001763 PBP superfamily domain; Region: PBP_like_2; cl17296 718271001764 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 718271001765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271001766 dimer interface [polypeptide binding]; other site 718271001767 conserved gate region; other site 718271001768 putative PBP binding loops; other site 718271001769 ABC-ATPase subunit interface; other site 718271001770 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 718271001771 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 718271001772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271001773 dimer interface [polypeptide binding]; other site 718271001774 conserved gate region; other site 718271001775 putative PBP binding loops; other site 718271001776 ABC-ATPase subunit interface; other site 718271001777 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14269 718271001778 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 718271001779 Walker A/P-loop; other site 718271001780 ATP binding site [chemical binding]; other site 718271001781 Q-loop/lid; other site 718271001782 ABC transporter signature motif; other site 718271001783 Walker B; other site 718271001784 D-loop; other site 718271001785 H-loop/switch region; other site 718271001786 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 718271001787 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 718271001788 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 718271001789 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 718271001790 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 718271001791 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 718271001792 Acylphosphatase; Region: Acylphosphatase; pfam00708 718271001793 HypF finger; Region: zf-HYPF; pfam07503 718271001794 HypF finger; Region: zf-HYPF; pfam07503 718271001795 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 718271001796 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718271001797 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 718271001798 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 718271001799 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 718271001800 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 718271001801 dimerization interface [polypeptide binding]; other site 718271001802 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 718271001803 ATP binding site [chemical binding]; other site 718271001804 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 718271001805 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 718271001806 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 718271001807 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 718271001808 DNA methylase; Region: N6_N4_Mtase; pfam01555 718271001809 DNA methylase; Region: N6_N4_Mtase; pfam01555 718271001810 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718271001811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 718271001812 ATP binding site [chemical binding]; other site 718271001813 putative Mg++ binding site [ion binding]; other site 718271001814 DNA polymerase III subunit delta; Validated; Region: PRK08487 718271001815 Exoribonuclease R [Transcription]; Region: VacB; COG0557 718271001816 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 718271001817 RNB domain; Region: RNB; pfam00773 718271001818 ketol-acid reductoisomerase; Provisional; Region: PRK05479 718271001819 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 718271001820 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 718271001821 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 718271001822 NodB motif; other site 718271001823 putative active site [active] 718271001824 putative catalytic site [active] 718271001825 Zn binding site [ion binding]; other site 718271001826 DNA protecting protein DprA; Region: dprA; TIGR00732 718271001827 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 718271001828 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 718271001829 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 718271001830 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 718271001831 methionine sulfoxide reductase A; Provisional; Region: PRK14054 718271001832 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 718271001833 dimer interface [polypeptide binding]; other site 718271001834 substrate binding site [chemical binding]; other site 718271001835 metal binding sites [ion binding]; metal-binding site 718271001836 adenylate kinase; Reviewed; Region: adk; PRK00279 718271001837 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 718271001838 AMP-binding site [chemical binding]; other site 718271001839 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 718271001840 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 718271001841 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 718271001842 dimer interface [polypeptide binding]; other site 718271001843 anticodon binding site; other site 718271001844 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 718271001845 homodimer interface [polypeptide binding]; other site 718271001846 motif 1; other site 718271001847 active site 718271001848 motif 2; other site 718271001849 GAD domain; Region: GAD; pfam02938 718271001850 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 718271001851 active site 718271001852 motif 3; other site 718271001853 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: pnk; PRK14077 718271001854 ATP-NAD kinase; Region: NAD_kinase; pfam01513 718271001855 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 718271001856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718271001857 Walker A/P-loop; other site 718271001858 ATP binding site [chemical binding]; other site 718271001859 Q-loop/lid; other site 718271001860 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 718271001861 ABC transporter signature motif; other site 718271001862 Walker B; other site 718271001863 D-loop; other site 718271001864 H-loop/switch region; other site 718271001865 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 718271001866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718271001867 active site 718271001868 phosphorylation site [posttranslational modification] 718271001869 intermolecular recognition site; other site 718271001870 dimerization interface [polypeptide binding]; other site 718271001871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718271001872 active site 718271001873 phosphorylation site [posttranslational modification] 718271001874 intermolecular recognition site; other site 718271001875 dimerization interface [polypeptide binding]; other site 718271001876 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718271001877 metal binding site [ion binding]; metal-binding site 718271001878 active site 718271001879 I-site; other site 718271001880 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 718271001881 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 718271001882 active site 718271001883 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 718271001884 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718271001885 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718271001886 catalytic residue [active] 718271001887 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 718271001888 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 718271001889 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 718271001890 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 718271001891 Sporulation related domain; Region: SPOR; pfam05036 718271001892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718271001893 active site 718271001894 motif I; other site 718271001895 motif II; other site 718271001896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 718271001897 OstA-like protein; Region: OstA; pfam03968 718271001898 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 718271001899 G1 box; other site 718271001900 GTP/Mg2+ binding site [chemical binding]; other site 718271001901 Switch I region; other site 718271001902 G2 box; other site 718271001903 G3 box; other site 718271001904 Switch II region; other site 718271001905 G4 box; other site 718271001906 G5 box; other site 718271001907 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 718271001908 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 718271001909 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 718271001910 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 718271001911 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 718271001912 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 718271001913 active site 718271001914 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 718271001915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271001916 putative substrate translocation pore; other site 718271001917 POT family; Region: PTR2; cl17359 718271001918 potential frameshift: common BLAST hit: gi|153951072|ref|YP_001398387.1| di-/tripeptide transporter 718271001919 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 718271001920 POT family; Region: PTR2; cl17359 718271001921 potential frameshift: common BLAST hit: gi|121612355|ref|YP_001000358.1| di-/tripeptide transporter 718271001922 potential frameshift: common BLAST hit: gi|121612355|ref|YP_001000358.1| di-/tripeptide transporter 718271001923 POT family; Region: PTR2; cl17359 718271001924 POT family; Region: PTR2; cl17359 718271001925 GTPase Era; Reviewed; Region: era; PRK00089 718271001926 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 718271001927 G1 box; other site 718271001928 GTP/Mg2+ binding site [chemical binding]; other site 718271001929 Switch I region; other site 718271001930 G2 box; other site 718271001931 Switch II region; other site 718271001932 G3 box; other site 718271001933 G4 box; other site 718271001934 G5 box; other site 718271001935 KH domain; Region: KH_2; pfam07650 718271001936 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 718271001937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271001938 Walker A motif; other site 718271001939 ATP binding site [chemical binding]; other site 718271001940 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 718271001941 Walker B motif; other site 718271001942 arginine finger; other site 718271001943 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 718271001944 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 718271001945 active site 718271001946 HslU subunit interaction site [polypeptide binding]; other site 718271001947 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 718271001948 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 718271001949 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 718271001950 argininosuccinate synthase; Provisional; Region: PRK13820 718271001951 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 718271001952 ANP binding site [chemical binding]; other site 718271001953 Substrate Binding Site II [chemical binding]; other site 718271001954 Substrate Binding Site I [chemical binding]; other site 718271001955 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis]; Region: COG1188 718271001956 RNA binding surface [nucleotide binding]; other site 718271001957 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 718271001958 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 718271001959 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 718271001960 Walker A/P-loop; other site 718271001961 ATP binding site [chemical binding]; other site 718271001962 Q-loop/lid; other site 718271001963 ABC transporter signature motif; other site 718271001964 Walker B; other site 718271001965 D-loop; other site 718271001966 H-loop/switch region; other site 718271001967 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 718271001968 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 718271001969 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 718271001970 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 718271001971 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 718271001972 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 718271001973 Potassium-transporting ATPase A chain;TC 3.A.3.7.1 718271001974 Potassium-transporting ATPase B chain;TC 3.A.3.7.1 718271001975 K+-transporting ATPase, c chain; Region: KdpC; cl00944 718271001976 Osmosensitive K+ channel histidine kinase KdpD 718271001977 excinuclease ABC subunit B; Provisional; Region: PRK05298 718271001978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718271001979 ATP binding site [chemical binding]; other site 718271001980 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718271001981 nucleotide binding region [chemical binding]; other site 718271001982 ATP-binding site [chemical binding]; other site 718271001983 Ultra-violet resistance protein B; Region: UvrB; pfam12344 718271001984 primosome assembly protein PriA; Validated; Region: PRK05580 718271001985 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718271001986 ATP binding site [chemical binding]; other site 718271001987 putative Mg++ binding site [ion binding]; other site 718271001988 helicase superfamily c-terminal domain; Region: HELICc; smart00490 718271001989 ATP-binding site [chemical binding]; other site 718271001990 invasion phenotype protein 718271001991 Predicted transcriptional regulator [Transcription]; Region: COG2932 718271001992 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 718271001993 Catalytic site [active] 718271001994 Integrase core domain; Region: rve; pfam00665 718271001995 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 718271001996 AAA domain; Region: AAA_22; pfam13401 718271001997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271001998 Walker A motif; other site 718271001999 ATP binding site [chemical binding]; other site 718271002000 Walker B motif; other site 718271002001 arginine finger; other site 718271002002 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 718271002003 DNA binding residues [nucleotide binding] 718271002004 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 718271002005 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 718271002006 YopX protein; Region: YopX; pfam09643 718271002007 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 718271002008 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 718271002009 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 718271002010 Protein of unknown function (DUF935); Region: DUF935; pfam06074 718271002011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 718271002012 Terminase-like family; Region: Terminase_6; pfam03237 718271002013 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 718271002014 Peptidase M15; Region: Peptidase_M15_3; cl01194 718271002015 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 718271002016 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 718271002017 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 718271002018 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 718271002019 rod shape-determining protein MreC; Provisional; Region: PRK13922 718271002020 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 718271002021 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 718271002022 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 718271002023 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 718271002024 Baseplate J-like protein; Region: Baseplate_J; cl01294 718271002025 Baseplate J-like protein; Region: Baseplate_J; pfam04865 718271002026 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 718271002027 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 718271002028 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 718271002029 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 718271002030 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 718271002031 Phage tail tube protein FII; Region: Phage_tube; cl01390 718271002032 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 718271002033 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 718271002034 Phage Tail Protein X; Region: Phage_tail_X; cl02088 718271002035 Phage protein D [General function prediction only]; Region: COG3500 718271002036 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 718271002037 Predicted transcriptional regulator [Transcription]; Region: COG2932 718271002038 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 718271002039 Catalytic site [active] 718271002040 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 718271002041 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 718271002042 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 718271002043 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 718271002044 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 718271002045 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 718271002046 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 718271002047 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 718271002048 propionate/acetate kinase; Provisional; Region: PRK12379 718271002049 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 718271002050 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 718271002051 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 718271002052 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 718271002053 MraW methylase family; Region: Methyltransf_5; cl17771 718271002054 SurA N-terminal domain; Region: SurA_N_3; cl07813 718271002055 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 718271002056 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 718271002057 cell division protein FtsA; Region: ftsA; TIGR01174 718271002058 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718271002059 nucleotide binding site [chemical binding]; other site 718271002060 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 718271002061 Cell division protein FtsA; Region: FtsA; pfam14450 718271002062 cell division protein FtsZ; Validated; Region: PRK09330 718271002063 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 718271002064 nucleotide binding site [chemical binding]; other site 718271002065 SulA interaction site; other site 718271002066 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 718271002067 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718271002068 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 718271002069 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 718271002070 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718271002071 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718271002072 glutamine synthetase, type I; Region: GlnA; TIGR00653 718271002073 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 718271002074 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 718271002075 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 718271002076 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 718271002077 Peptidase family U32; Region: Peptidase_U32; pfam01136 718271002078 AIR carboxylase; Region: AIRC; smart01001 718271002079 Protein of unknown function (DUF3972); Region: DUF3972; pfam13118 718271002080 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 718271002081 dimer interface [polypeptide binding]; other site 718271002082 motif 1; other site 718271002083 active site 718271002084 motif 2; other site 718271002085 motif 3; other site 718271002086 Uncharacterized conserved protein [Function unknown]; Region: COG0327 718271002087 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 718271002088 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 718271002089 Putative zinc ribbon domain; Region: DUF164; pfam02591 718271002090 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 718271002091 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 718271002092 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 718271002093 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 718271002094 active site 718271002095 signal recognition particle protein; Provisional; Region: PRK10867 718271002096 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 718271002097 P loop; other site 718271002098 GTP binding site [chemical binding]; other site 718271002099 Signal peptide binding domain; Region: SRP_SPB; pfam02978 718271002100 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 718271002101 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 718271002102 KH domain; Region: KH_4; pfam13083 718271002103 G-X-X-G motif; other site 718271002104 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 718271002105 RimM N-terminal domain; Region: RimM; pfam01782 718271002106 PRC-barrel domain; Region: PRC; pfam05239 718271002107 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 718271002108 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 718271002109 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 718271002110 active site 718271002111 homotetramer interface [polypeptide binding]; other site 718271002112 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 718271002113 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 718271002114 ArsC family; Region: ArsC; pfam03960 718271002115 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 718271002116 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 718271002117 active site 718271002118 PHP Thumb interface [polypeptide binding]; other site 718271002119 metal binding site [ion binding]; metal-binding site 718271002120 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 718271002121 generic binding surface I; other site 718271002122 generic binding surface II; other site 718271002123 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 718271002124 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718271002125 catalytic residue [active] 718271002126 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 718271002127 flagellin; Provisional; Region: PRK12804 718271002128 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 718271002129 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 718271002130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 718271002131 Peptidase family M48; Region: Peptidase_M48; pfam01435 718271002132 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 718271002133 MPT binding site; other site 718271002134 trimer interface [polypeptide binding]; other site 718271002135 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 718271002136 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 718271002137 oligomer interface [polypeptide binding]; other site 718271002138 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 718271002139 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 718271002140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 718271002141 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 718271002142 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4132 718271002143 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 718271002144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271002145 dimer interface [polypeptide binding]; other site 718271002146 conserved gate region; other site 718271002147 putative PBP binding loops; other site 718271002148 ABC-ATPase subunit interface; other site 718271002149 Ferric iron ABC transporter, ATP-binding protein 718271002150 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 718271002151 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 718271002152 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718271002153 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 718271002154 substrate binding pocket [chemical binding]; other site 718271002155 membrane-bound complex binding site; other site 718271002156 hinge residues; other site 718271002157 Putative periplasmic protein 718271002158 haemagglutination activity domain; Region: Haemagg_act; smart00912 718271002159 potential frameshift: common BLAST hit: gi|121613175|ref|YP_001000437.1| putative outer-membrane protein 718271002160 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 718271002161 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 718271002162 Probable transposase; Region: OrfB_IS605; pfam01385 718271002163 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 718271002164 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 718271002165 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 718271002166 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 718271002167 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 718271002168 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718271002169 N-terminal plug; other site 718271002170 ligand-binding site [chemical binding]; other site 718271002171 heat-inducible transcription repressor; Provisional; Region: PRK03911 718271002172 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 718271002173 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 718271002174 dimer interface [polypeptide binding]; other site 718271002175 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 718271002176 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 718271002177 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 718271002178 nucleotide binding site [chemical binding]; other site 718271002179 NEF interaction site [polypeptide binding]; other site 718271002180 SBD interface [polypeptide binding]; other site 718271002181 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 718271002182 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 718271002183 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 718271002184 aspartate aminotransferase; Provisional; Region: PRK05764 718271002185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718271002186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271002187 homodimer interface [polypeptide binding]; other site 718271002188 catalytic residue [active] 718271002189 serine O-acetyltransferase; Region: cysE; TIGR01172 718271002190 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 718271002191 trimer interface [polypeptide binding]; other site 718271002192 active site 718271002193 substrate binding site [chemical binding]; other site 718271002194 CoA binding site [chemical binding]; other site 718271002195 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 718271002196 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 718271002197 dimer interface [polypeptide binding]; other site 718271002198 active site 718271002199 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718271002200 catalytic residues [active] 718271002201 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 718271002202 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 718271002203 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 718271002204 dimer interface [polypeptide binding]; other site 718271002205 motif 1; other site 718271002206 active site 718271002207 motif 2; other site 718271002208 motif 3; other site 718271002209 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 718271002210 anticodon binding site; other site 718271002211 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 718271002212 thymidylate kinase; Validated; Region: tmk; PRK00698 718271002213 TMP-binding site; other site 718271002214 ATP-binding site [chemical binding]; other site 718271002215 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 718271002216 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 718271002217 active site 718271002218 (T/H)XGH motif; other site 718271002219 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 718271002220 Flavoprotein; Region: Flavoprotein; pfam02441 718271002221 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515 718271002222 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 718271002223 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 718271002224 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 718271002225 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 718271002226 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 718271002227 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 718271002228 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 718271002229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271002230 ABC-ATPase subunit interface; other site 718271002231 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 718271002232 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 718271002233 Walker A/P-loop; other site 718271002234 ATP binding site [chemical binding]; other site 718271002235 Q-loop/lid; other site 718271002236 ABC transporter signature motif; other site 718271002237 Walker B; other site 718271002238 D-loop; other site 718271002239 H-loop/switch region; other site 718271002240 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 718271002241 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 718271002242 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 718271002243 active site 718271002244 HIGH motif; other site 718271002245 nucleotide binding site [chemical binding]; other site 718271002246 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 718271002247 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 718271002248 active site 718271002249 KMSKS motif; other site 718271002250 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 718271002251 tRNA binding surface [nucleotide binding]; other site 718271002252 anticodon binding site; other site 718271002253 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 718271002254 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 718271002255 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 718271002256 Part of AAA domain; Region: AAA_19; pfam13245 718271002257 Family description; Region: UvrD_C_2; pfam13538 718271002258 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 718271002259 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 718271002260 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 718271002261 dimer interface [polypeptide binding]; other site 718271002262 catalytic triad [active] 718271002263 peroxidatic and resolving cysteines [active] 718271002264 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 718271002265 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 718271002266 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718271002267 molybdopterin cofactor binding site; other site 718271002268 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718271002269 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 718271002270 molybdopterin cofactor binding site; other site 718271002271 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 718271002272 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718271002273 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 718271002274 4Fe-4S binding domain; Region: Fer4_5; pfam12801 718271002275 4Fe-4S binding domain; Region: Fer4; cl02805 718271002276 Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043 718271002277 FOG: WD40 repeat [General function prediction only]; Region: COG2319 718271002278 Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062 718271002279 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 718271002280 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 718271002281 active site 718271002282 NTP binding site [chemical binding]; other site 718271002283 metal binding triad [ion binding]; metal-binding site 718271002284 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 718271002285 Formyltetrahydrofolate hydrolase [Nucleotide transport and metabolism]; Region: PurU; COG0788 718271002286 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 718271002287 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 718271002288 putative active site [active] 718271002289 putative substrate binding site [chemical binding]; other site 718271002290 putative cosubstrate binding site; other site 718271002291 catalytic site [active] 718271002292 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 718271002293 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 718271002294 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718271002295 catalytic residue [active] 718271002296 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 718271002297 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 718271002298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718271002299 dimer interface [polypeptide binding]; other site 718271002300 phosphorylation site [posttranslational modification] 718271002301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718271002302 ATP binding site [chemical binding]; other site 718271002303 Mg2+ binding site [ion binding]; other site 718271002304 G-X-G motif; other site 718271002305 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 718271002306 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718271002307 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 718271002308 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 718271002309 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 718271002310 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 718271002311 ATP-grasp domain; Region: ATP-grasp_4; cl17255 718271002312 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14601 718271002313 RuvA N terminal domain; Region: RuvA_N; pfam01330 718271002314 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 718271002315 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 718271002316 Protein of unknown function (DUF342); Region: DUF342; pfam03961 718271002317 integral membrane protein MviN; Region: mviN; TIGR01695 718271002318 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 718271002319 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 718271002320 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 718271002321 active site 718271002322 HIGH motif; other site 718271002323 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 718271002324 KMSKS motif; other site 718271002325 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 718271002326 tRNA binding surface [nucleotide binding]; other site 718271002327 anticodon binding site; other site 718271002328 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 718271002329 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 718271002330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718271002331 Walker A/P-loop; other site 718271002332 ATP binding site [chemical binding]; other site 718271002333 Q-loop/lid; other site 718271002334 ABC transporter signature motif; other site 718271002335 Walker B; other site 718271002336 D-loop; other site 718271002337 H-loop/switch region; other site 718271002338 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 718271002339 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 718271002340 quinone interaction residues [chemical binding]; other site 718271002341 active site 718271002342 catalytic residues [active] 718271002343 FMN binding site [chemical binding]; other site 718271002344 substrate binding site [chemical binding]; other site 718271002345 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 718271002346 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 718271002347 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 718271002348 dihydrodipicolinate synthase; Region: dapA; TIGR00674 718271002349 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 718271002350 dimer interface [polypeptide binding]; other site 718271002351 active site 718271002352 catalytic residue [active] 718271002353 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 718271002354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718271002355 NAD(P) binding site [chemical binding]; other site 718271002356 active site 718271002357 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 718271002358 NAD synthetase; Provisional; Region: PRK13980 718271002359 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 718271002360 homodimer interface [polypeptide binding]; other site 718271002361 NAD binding pocket [chemical binding]; other site 718271002362 ATP binding pocket [chemical binding]; other site 718271002363 Mg binding site [ion binding]; other site 718271002364 active-site loop [active] 718271002365 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 718271002366 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 718271002367 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 718271002368 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 718271002369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271002370 catalytic residue [active] 718271002371 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 718271002372 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 718271002373 Ligand binding site; other site 718271002374 oligomer interface; other site 718271002375 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 718271002376 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718271002377 substrate binding pocket [chemical binding]; other site 718271002378 membrane-bound complex binding site; other site 718271002379 hinge residues; other site 718271002380 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 718271002381 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 718271002382 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 718271002383 Substrate binding site; other site 718271002384 Mg++ binding site; other site 718271002385 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 718271002386 active site 718271002387 substrate binding site [chemical binding]; other site 718271002388 CoA binding site [chemical binding]; other site 718271002389 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 718271002390 Flavoprotein; Region: Flavoprotein; pfam02441 718271002391 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 718271002392 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 718271002393 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 718271002394 catalytic residue [active] 718271002395 putative FPP diphosphate binding site; other site 718271002396 putative FPP binding hydrophobic cleft; other site 718271002397 dimer interface [polypeptide binding]; other site 718271002398 putative IPP diphosphate binding site; other site 718271002399 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 718271002400 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 718271002401 Predicted permeases [General function prediction only]; Region: COG0795 718271002402 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 718271002403 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 718271002404 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 718271002405 dimerization interface 3.5A [polypeptide binding]; other site 718271002406 active site 718271002407 threonine dehydratase; Provisional; Region: PRK08526 718271002408 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 718271002409 tetramer interface [polypeptide binding]; other site 718271002410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271002411 catalytic residue [active] 718271002412 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 718271002413 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 718271002414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 718271002415 tRNA (Uracil-5-)-methyltransferase; Region: tRNA_U5-meth_tr; pfam05958 718271002416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718271002417 S-adenosylmethionine binding site [chemical binding]; other site 718271002418 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 718271002419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718271002420 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 718271002421 NAD(P) binding site [chemical binding]; other site 718271002422 active site 718271002423 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 718271002424 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 718271002425 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 718271002426 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 718271002427 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 718271002428 substrate binding site [chemical binding]; other site 718271002429 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 718271002430 substrate binding site [chemical binding]; other site 718271002431 ligand binding site [chemical binding]; other site 718271002432 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 718271002433 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 718271002434 DNA binding site [nucleotide binding] 718271002435 active site 718271002436 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 718271002437 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 718271002438 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 718271002439 active site 718271002440 HIGH motif; other site 718271002441 KMSKS motif; other site 718271002442 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 718271002443 tRNA binding surface [nucleotide binding]; other site 718271002444 anticodon binding site; other site 718271002445 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 718271002446 putative tRNA-binding site [nucleotide binding]; other site 718271002447 dimer interface [polypeptide binding]; other site 718271002448 Fructose-1,6-bisphosphatase [Carbohydrate transport and metabolism]; Region: Fbp; COG0158 718271002449 active site 718271002450 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 718271002451 Walker A motif; other site 718271002452 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 718271002453 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718271002454 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718271002455 catalytic residue [active] 718271002456 YGGT family; Region: YGGT; pfam02325 718271002457 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 718271002458 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 718271002459 active site 718271002460 HIGH motif; other site 718271002461 nucleotide binding site [chemical binding]; other site 718271002462 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 718271002463 active site 718271002464 KMSKS motif; other site 718271002465 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 718271002466 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 718271002467 putative active site [active] 718271002468 putative metal binding site [ion binding]; other site 718271002469 phosphatidylserine decarboxylase; Provisional; Region: PRK03934 718271002470 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 718271002471 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 718271002472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271002473 putative substrate translocation pore; other site 718271002474 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718271002475 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 718271002476 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 718271002477 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 718271002478 inhibitor-cofactor binding pocket; inhibition site 718271002479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271002480 catalytic residue [active] 718271002481 ubiquitin-activating enzyme E1; Region: Ube1; TIGR01408 718271002482 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14166 718271002483 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 718271002484 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 718271002485 homodimer interface [polypeptide binding]; other site 718271002486 NADP binding site [chemical binding]; other site 718271002487 substrate binding site [chemical binding]; other site 718271002488 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 718271002489 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 718271002490 Catalytic site [active] 718271002491 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 718271002492 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 718271002493 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 718271002494 dimer interface [polypeptide binding]; other site 718271002495 putative functional site; other site 718271002496 putative MPT binding site; other site 718271002497 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 718271002498 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 718271002499 hinge; other site 718271002500 active site 718271002501 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 718271002502 EamA-like transporter family; Region: EamA; pfam00892 718271002503 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 718271002504 Glutamine amidotransferase class-I; Region: GATase; pfam00117 718271002505 glutamine binding [chemical binding]; other site 718271002506 catalytic triad [active] 718271002507 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 718271002508 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 718271002509 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 718271002510 substrate-cofactor binding pocket; other site 718271002511 homodimer interface [polypeptide binding]; other site 718271002512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271002513 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 718271002514 catalytic residue [active] 718271002515 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 718271002516 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 718271002517 active site 718271002518 DNA binding site [nucleotide binding] 718271002519 Int/Topo IB signature motif; other site 718271002520 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 718271002521 catalytic residues [active] 718271002522 hinge region; other site 718271002523 alpha helical domain; other site 718271002524 putative disulfide oxidoreductase; Provisional; Region: PRK04307 718271002525 arylsulfate sulfotransferase 718271002526 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 718271002527 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 718271002528 catalytic residues [active] 718271002529 hinge region; other site 718271002530 alpha helical domain; other site 718271002531 Cytochrome c; Region: Cytochrom_C; pfam00034 718271002532 Cytochrome c [Energy production and conversion]; Region: COG3258 718271002533 DHH family; Region: DHH; pfam01368 718271002534 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 718271002535 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 718271002536 FHIPEP family; Region: FHIPEP; pfam00771 718271002537 Rrf2 family protein; Region: rrf2_super; TIGR00738 718271002538 Transcriptional regulator; Region: Rrf2; pfam02082 718271002539 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 718271002540 16S/18S rRNA binding site [nucleotide binding]; other site 718271002541 S13e-L30e interaction site [polypeptide binding]; other site 718271002542 25S rRNA binding site [nucleotide binding]; other site 718271002543 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 718271002544 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 718271002545 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 718271002546 lagellar hook-associated protein FlgL; Provisional; Region: PRK14692 718271002547 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 718271002548 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 718271002549 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 718271002550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718271002551 Walker A/P-loop; other site 718271002552 ATP binding site [chemical binding]; other site 718271002553 Q-loop/lid; other site 718271002554 ABC transporter signature motif; other site 718271002555 Walker B; other site 718271002556 D-loop; other site 718271002557 H-loop/switch region; other site 718271002558 ABC transporter; Region: ABC_tran_2; pfam12848 718271002559 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718271002560 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 718271002561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718271002562 ATP binding site [chemical binding]; other site 718271002563 Mg2+ binding site [ion binding]; other site 718271002564 G-X-G motif; other site 718271002565 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 718271002566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718271002567 active site 718271002568 phosphorylation site [posttranslational modification] 718271002569 intermolecular recognition site; other site 718271002570 dimerization interface [polypeptide binding]; other site 718271002571 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718271002572 DNA binding site [nucleotide binding] 718271002573 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 718271002574 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 718271002575 ligand binding site [chemical binding]; other site 718271002576 NAD binding site [chemical binding]; other site 718271002577 dimerization interface [polypeptide binding]; other site 718271002578 catalytic site [active] 718271002579 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 718271002580 putative L-serine binding site [chemical binding]; other site 718271002581 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 718271002582 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 718271002583 RNA binding site [nucleotide binding]; other site 718271002584 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 718271002585 RNA binding site [nucleotide binding]; other site 718271002586 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 718271002587 RNA binding site [nucleotide binding]; other site 718271002588 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 718271002589 RNA binding site [nucleotide binding]; other site 718271002590 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 718271002591 RNA binding site [nucleotide binding]; other site 718271002592 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 718271002593 RNA binding site [nucleotide binding]; other site 718271002594 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 718271002595 LytB protein; Region: LYTB; pfam02401 718271002596 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 718271002597 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 718271002598 hinge; other site 718271002599 active site 718271002600 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 718271002601 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 718271002602 putative tRNA-binding site [nucleotide binding]; other site 718271002603 B3/4 domain; Region: B3_4; pfam03483 718271002604 tRNA synthetase B5 domain; Region: B5; smart00874 718271002605 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 718271002606 dimer interface [polypeptide binding]; other site 718271002607 motif 1; other site 718271002608 motif 3; other site 718271002609 motif 2; other site 718271002610 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 718271002611 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 718271002612 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 718271002613 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 718271002614 dimer interface [polypeptide binding]; other site 718271002615 motif 1; other site 718271002616 active site 718271002617 motif 2; other site 718271002618 motif 3; other site 718271002619 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 718271002620 nucleotide binding site/active site [active] 718271002621 HIT family signature motif; other site 718271002622 catalytic residue [active] 718271002623 DJ-1 family protein; Region: not_thiJ; TIGR01383 718271002624 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 718271002625 conserved cys residue [active] 718271002626 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 718271002627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271002628 dimer interface [polypeptide binding]; other site 718271002629 conserved gate region; other site 718271002630 putative PBP binding loops; other site 718271002631 ABC-ATPase subunit interface; other site 718271002632 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 718271002633 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 718271002634 Walker A/P-loop; other site 718271002635 ATP binding site [chemical binding]; other site 718271002636 Q-loop/lid; other site 718271002637 ABC transporter signature motif; other site 718271002638 Walker B; other site 718271002639 D-loop; other site 718271002640 H-loop/switch region; other site 718271002641 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 718271002642 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 718271002643 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 718271002644 alanine racemase; Reviewed; Region: alr; PRK00053 718271002645 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 718271002646 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718271002647 catalytic residue [active] 718271002648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 718271002649 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 718271002650 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 718271002651 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 718271002652 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 718271002653 Cu(I) binding site [ion binding]; other site 718271002654 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 718271002655 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 718271002656 dimer interface [polypeptide binding]; other site 718271002657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271002658 catalytic residue [active] 718271002659 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 718271002660 IHF dimer interface [polypeptide binding]; other site 718271002661 IHF - DNA interface [nucleotide binding]; other site 718271002662 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 718271002663 Protein of unknown function (DUF466); Region: DUF466; cl01082 718271002664 carbon starvation protein A 718271002665 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 718271002666 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 718271002667 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718271002668 active site 718271002669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271002670 dimer interface [polypeptide binding]; other site 718271002671 conserved gate region; other site 718271002672 putative PBP binding loops; other site 718271002673 ABC-ATPase subunit interface; other site 718271002674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271002675 dimer interface [polypeptide binding]; other site 718271002676 conserved gate region; other site 718271002677 putative PBP binding loops; other site 718271002678 ABC-ATPase subunit interface; other site 718271002679 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 718271002680 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718271002681 substrate binding pocket [chemical binding]; other site 718271002682 membrane-bound complex binding site; other site 718271002683 hinge residues; other site 718271002684 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 718271002685 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 718271002686 Walker A/P-loop; other site 718271002687 ATP binding site [chemical binding]; other site 718271002688 Q-loop/lid; other site 718271002689 ABC transporter signature motif; other site 718271002690 Walker B; other site 718271002691 D-loop; other site 718271002692 H-loop/switch region; other site 718271002693 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 718271002694 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 718271002695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718271002696 S-adenosylmethionine binding site [chemical binding]; other site 718271002697 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 718271002698 CheB methylesterase; Region: CheB_methylest; pfam01339 718271002699 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 718271002700 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 718271002701 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 718271002702 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718271002703 active site 718271002704 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 718271002705 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 718271002706 multifunctional aminopeptidase A; Provisional; Region: PRK00913 718271002707 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 718271002708 interface (dimer of trimers) [polypeptide binding]; other site 718271002709 Substrate-binding/catalytic site; other site 718271002710 Zn-binding sites [ion binding]; other site 718271002711 GTP-binding protein YchF; Reviewed; Region: PRK09601 718271002712 YchF GTPase; Region: YchF; cd01900 718271002713 G1 box; other site 718271002714 GTP/Mg2+ binding site [chemical binding]; other site 718271002715 Switch I region; other site 718271002716 G2 box; other site 718271002717 Switch II region; other site 718271002718 G3 box; other site 718271002719 G4 box; other site 718271002720 G5 box; other site 718271002721 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 718271002722 argininosuccinate lyase; Provisional; Region: PRK00855 718271002723 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 718271002724 active sites [active] 718271002725 tetramer interface [polypeptide binding]; other site 718271002726 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 718271002727 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 718271002728 active site 718271002729 substrate-binding site [chemical binding]; other site 718271002730 metal-binding site [ion binding] 718271002731 ATP binding site [chemical binding]; other site 718271002732 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 718271002733 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 718271002734 active site 718271002735 catalytic residues [active] 718271002736 metal binding site [ion binding]; metal-binding site 718271002737 homodimer binding site [polypeptide binding]; other site 718271002738 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 718271002739 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 718271002740 carboxyltransferase (CT) interaction site; other site 718271002741 biotinylation site [posttranslational modification]; other site 718271002742 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 718271002743 Na2 binding site [ion binding]; other site 718271002744 putative substrate binding site 1 [chemical binding]; other site 718271002745 Na binding site 1 [ion binding]; other site 718271002746 putative substrate binding site 2 [chemical binding]; other site 718271002747 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 718271002748 Na2 binding site [ion binding]; other site 718271002749 putative substrate binding site 1 [chemical binding]; other site 718271002750 Na binding site 1 [ion binding]; other site 718271002751 putative substrate binding site 2 [chemical binding]; other site 718271002752 F0F1 ATP synthase subunit C; Validated; Region: PRK08482 718271002753 Predicted permeases [General function prediction only]; Region: COG0679 718271002754 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 718271002755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271002756 putative substrate translocation pore; other site 718271002757 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 718271002758 putative acyl-acceptor binding pocket; other site 718271002759 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 718271002760 acyl-activating enzyme (AAE) consensus motif; other site 718271002761 AMP binding site [chemical binding]; other site 718271002762 active site 718271002763 CoA binding site [chemical binding]; other site 718271002764 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 718271002765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271002766 dimer interface [polypeptide binding]; other site 718271002767 conserved gate region; other site 718271002768 putative PBP binding loops; other site 718271002769 ABC-ATPase subunit interface; other site 718271002770 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 718271002771 FtsX-like permease family; Region: FtsX; pfam02687 718271002772 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 718271002773 DEAD/DEAH box helicase; Region: DEAD; pfam00270 718271002774 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 718271002775 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718271002776 nucleotide binding region [chemical binding]; other site 718271002777 ATP-binding site [chemical binding]; other site 718271002778 SEC-C motif; Region: SEC-C; pfam02810 718271002779 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 718271002780 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 718271002781 PIF1-like helicase; Region: PIF1; pfam05970 718271002782 Helicase; Region: Herpes_Helicase; pfam02689 718271002783 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 718271002784 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 718271002785 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 718271002786 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 718271002787 NlpC/P60 family; Region: NLPC_P60; cl17555 718271002788 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 718271002789 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 718271002790 putative active site; other site 718271002791 catalytic triad [active] 718271002792 putative dimer interface [polypeptide binding]; other site 718271002793 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 718271002794 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 718271002795 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 718271002796 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 718271002797 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 718271002798 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718271002799 dimer interface [polypeptide binding]; other site 718271002800 putative CheW interface [polypeptide binding]; other site 718271002801 potential frameshift: common BLAST hit: gi|315124450|ref|YP_004066454.1| methyl-accepting chemotaxis protein 718271002802 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 718271002803 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 718271002804 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 718271002805 purine monophosphate binding site [chemical binding]; other site 718271002806 dimer interface [polypeptide binding]; other site 718271002807 putative catalytic residues [active] 718271002808 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 718271002809 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 718271002810 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 718271002811 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 718271002812 putative metal binding site [ion binding]; other site 718271002813 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 718271002814 HSP70 interaction site [polypeptide binding]; other site 718271002815 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 718271002816 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 718271002817 dimerization interface [polypeptide binding]; other site 718271002818 ATP binding site [chemical binding]; other site 718271002819 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 718271002820 dimerization interface [polypeptide binding]; other site 718271002821 ATP binding site [chemical binding]; other site 718271002822 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 718271002823 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 718271002824 trmE is a tRNA modification GTPase; Region: trmE; cd04164 718271002825 G1 box; other site 718271002826 GTP/Mg2+ binding site [chemical binding]; other site 718271002827 Switch I region; other site 718271002828 G2 box; other site 718271002829 Switch II region; other site 718271002830 G3 box; other site 718271002831 G4 box; other site 718271002832 G5 box; other site 718271002833 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 718271002834 membrane protein insertase; Provisional; Region: PRK01318 718271002835 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 718271002836 Uncharacterized conserved protein [Function unknown]; Region: COG0759 718271002837 RNase P protein component [Translation, ribosomal structure and biogenesis]; Region: RnpA; COG0594 718271002838 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 718271002839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718271002840 Coenzyme A binding pocket [chemical binding]; other site 718271002841 Uracil-DNA glycosylase [DNA replication, recombination, and repair]; Region: COG1573 718271002842 ligand binding site [chemical binding]; other site 718271002843 active site 718271002844 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 718271002845 active site 718271002846 haemagglutination activity domain; Region: Haemagg_act; cl05436 718271002847 potential frameshift: common BLAST hit: gi|121612600|ref|YP_001000204.1| putative periplasmic protein 718271002848 potential frameshift: common BLAST hit: gi|121612600|ref|YP_001000204.1| putative periplasmic protein 718271002849 conserved hypothetical protein, degenerate 718271002850 Methyltransferase domain; Region: Methyltransf_23; pfam13489 718271002851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718271002852 S-adenosylmethionine binding site [chemical binding]; other site 718271002853 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 718271002854 active site 1 [active] 718271002855 active site 2 [active] 718271002856 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 718271002857 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 718271002858 Catalytic site; other site 718271002859 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 718271002860 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 718271002861 metal binding site [ion binding]; metal-binding site 718271002862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271002863 metabolite-proton symporter; Region: 2A0106; TIGR00883 718271002864 putative substrate translocation pore; other site 718271002865 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 718271002866 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718271002867 substrate binding pocket [chemical binding]; other site 718271002868 membrane-bound complex binding site; other site 718271002869 hinge residues; other site 718271002870 ADP-specific Phosphofructokinase/Glucokinase conserved region; Region: ADP_PFK_GK; cl14060 718271002871 Protein of unknown function (DUF328); Region: DUF328; cl01143 718271002872 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 718271002873 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 718271002874 metal binding site [ion binding]; metal-binding site 718271002875 putative dimer interface [polypeptide binding]; other site 718271002876 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 718271002877 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 718271002878 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718271002879 Cysteine-rich domain; Region: CCG; pfam02754 718271002880 Cysteine-rich domain; Region: CCG; pfam02754 718271002881 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 718271002882 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718271002883 FeS/SAM binding site; other site 718271002884 HemN C-terminal domain; Region: HemN_C; pfam06969 718271002885 Protein of unknown function (DUF2603); Region: DUF2603; pfam10788 718271002886 ornithine carbamoyltransferase; Provisional; Region: PRK00779 718271002887 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 718271002888 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 718271002889 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 718271002890 dimer interface [polypeptide binding]; other site 718271002891 active site 718271002892 Schiff base residues; other site 718271002893 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 718271002894 dimerization interface [polypeptide binding]; other site 718271002895 active site 718271002896 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 718271002897 16S rRNA (guanine(527)-N(7))-methyltransferase GidB; Region: gidB; TIGR00138 718271002898 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 718271002899 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718271002900 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718271002901 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718271002902 dimerization interface [polypeptide binding]; other site 718271002903 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 718271002904 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718271002905 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 718271002906 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718271002907 DNA binding residues [nucleotide binding] 718271002908 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 718271002909 catalytic core [active] 718271002910 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 718271002911 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 718271002912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271002913 Walker A motif; other site 718271002914 ATP binding site [chemical binding]; other site 718271002915 Walker B motif; other site 718271002916 arginine finger; other site 718271002917 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 718271002918 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 718271002919 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 718271002920 Mechanosensitive ion channel; Region: MS_channel; pfam00924 718271002921 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 718271002922 active site 718271002923 dimer interface [polypeptide binding]; other site 718271002924 metal binding site [ion binding]; metal-binding site 718271002925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 718271002926 TrkA-C domain; Region: TrkA_C; pfam02080 718271002927 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 718271002928 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 718271002929 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 718271002930 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 718271002931 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 718271002932 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 718271002933 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 718271002934 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 718271002935 Walker A/P-loop; other site 718271002936 ATP binding site [chemical binding]; other site 718271002937 Q-loop/lid; other site 718271002938 ABC transporter signature motif; other site 718271002939 Walker B; other site 718271002940 D-loop; other site 718271002941 H-loop/switch region; other site 718271002942 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 718271002943 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 718271002944 Walker A/P-loop; other site 718271002945 ATP binding site [chemical binding]; other site 718271002946 Q-loop/lid; other site 718271002947 ABC transporter signature motif; other site 718271002948 Walker B; other site 718271002949 D-loop; other site 718271002950 H-loop/switch region; other site 718271002951 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 718271002952 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 718271002953 TM-ABC transporter signature motif; other site 718271002954 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718271002955 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 718271002956 TM-ABC transporter signature motif; other site 718271002957 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 718271002958 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 718271002959 putative ligand binding site [chemical binding]; other site 718271002960 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 718271002961 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 718271002962 putative ligand binding site [chemical binding]; other site 718271002963 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 718271002964 Cytochrome c; Region: Cytochrom_C; cl11414 718271002965 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 718271002966 Predicted membrane protein [Function unknown]; Region: COG2862 718271002967 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 718271002968 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 718271002969 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 718271002970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718271002971 active site 718271002972 phosphorylation site [posttranslational modification] 718271002973 intermolecular recognition site; other site 718271002974 dimerization interface [polypeptide binding]; other site 718271002975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271002976 Walker A motif; other site 718271002977 ATP binding site [chemical binding]; other site 718271002978 Walker B motif; other site 718271002979 arginine finger; other site 718271002980 LPP20 lipoprotein; Region: LPP20; cl15824 718271002981 DNA gyrase subunit A; Validated; Region: PRK05560 718271002982 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 718271002983 CAP-like domain; other site 718271002984 active site 718271002985 primary dimer interface [polypeptide binding]; other site 718271002986 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718271002987 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718271002988 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718271002989 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718271002990 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718271002991 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 718271002992 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718271002993 active site 718271002994 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 718271002995 GTP-binding protein LepA; Provisional; Region: PRK05433 718271002996 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 718271002997 G1 box; other site 718271002998 putative GEF interaction site [polypeptide binding]; other site 718271002999 GTP/Mg2+ binding site [chemical binding]; other site 718271003000 Switch I region; other site 718271003001 G2 box; other site 718271003002 G3 box; other site 718271003003 Switch II region; other site 718271003004 G4 box; other site 718271003005 G5 box; other site 718271003006 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 718271003007 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 718271003008 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 718271003009 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 718271003010 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718271003011 HlyD family secretion protein; Region: HlyD_3; pfam13437 718271003012 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 718271003013 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 718271003014 HSP70 interaction site [polypeptide binding]; other site 718271003015 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 718271003016 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 718271003017 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 718271003018 acetyl-CoA carboxylase subunit A; Validated; Region: PRK08463 718271003019 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 718271003020 ATP-grasp domain; Region: ATP-grasp_4; cl17255 718271003021 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 718271003022 cell division protein FtsW; Region: ftsW; TIGR02614 718271003023 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 718271003024 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 718271003025 active site 718271003026 homodimer interface [polypeptide binding]; other site 718271003027 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 718271003028 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 718271003029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718271003030 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 718271003031 thiamine phosphate binding site [chemical binding]; other site 718271003032 active site 718271003033 pyrophosphate binding site [ion binding]; other site 718271003034 thiazole biosynthesis protein ThiH; Region: thiH; TIGR02351 718271003035 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718271003036 FeS/SAM binding site; other site 718271003037 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 718271003038 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 718271003039 ThiS interaction site; other site 718271003040 putative active site [active] 718271003041 tetramer interface [polypeptide binding]; other site 718271003042 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 718271003043 thiamine biosynthesis protein ThiF, family 2; Region: thiF_fam2; TIGR02354 718271003044 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 718271003045 putative ATP binding site [chemical binding]; other site 718271003046 putative substrate interface [chemical binding]; other site 718271003047 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 718271003048 thiS-thiF/thiG interaction site; other site 718271003049 succinyl-diaminopimelate desuccinylase, proteobacterial clade; Region: dapE_proteo; TIGR01246 718271003050 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 718271003051 metal binding site [ion binding]; metal-binding site 718271003052 dimer interface [polypeptide binding]; other site 718271003053 LysE type translocator; Region: LysE; pfam01810 718271003054 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 718271003055 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 718271003056 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 718271003057 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 718271003058 Methyltransferase domain; Region: Methyltransf_26; pfam13659 718271003059 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 718271003060 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 718271003061 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 718271003062 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 718271003063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718271003064 Walker A/P-loop; other site 718271003065 ATP binding site [chemical binding]; other site 718271003066 Q-loop/lid; other site 718271003067 ABC transporter signature motif; other site 718271003068 Walker B; other site 718271003069 D-loop; other site 718271003070 H-loop/switch region; other site 718271003071 Smr domain; Region: Smr; pfam01713 718271003072 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 718271003073 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 718271003074 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718271003075 Predicted amidohydrolase [General function prediction only]; Region: COG0388 718271003076 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 718271003077 active site 718271003078 catalytic triad [active] 718271003079 dimer interface [polypeptide binding]; other site 718271003080 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 718271003081 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 718271003082 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 718271003083 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 718271003084 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 718271003085 active site 718271003086 indole-3-acetamide amidohydrolase; Region: PLN02722 718271003087 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 718271003088 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 718271003089 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 718271003090 active site 718271003091 HIGH motif; other site 718271003092 nucleotide binding site [chemical binding]; other site 718271003093 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 718271003094 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 718271003095 active site 718271003096 KMSKS motif; other site 718271003097 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 718271003098 tRNA binding surface [nucleotide binding]; other site 718271003099 anticodon binding site; other site 718271003100 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 718271003101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718271003102 Coenzyme A binding pocket [chemical binding]; other site 718271003103 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 718271003104 dimer interface [polypeptide binding]; other site 718271003105 FMN binding site [chemical binding]; other site 718271003106 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 718271003107 dimer interface [polypeptide binding]; other site 718271003108 FMN binding site [chemical binding]; other site 718271003109 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 718271003110 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 718271003111 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 718271003112 active site 718271003113 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 718271003114 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 718271003115 putative substrate binding region [chemical binding]; other site 718271003116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 718271003117 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 718271003118 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 718271003119 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 718271003120 dimer interface [polypeptide binding]; other site 718271003121 ssDNA binding site [nucleotide binding]; other site 718271003122 tetramer (dimer of dimers) interface [polypeptide binding]; other site 718271003123 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 718271003124 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 718271003125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271003126 Walker A motif; other site 718271003127 ATP binding site [chemical binding]; other site 718271003128 Walker B motif; other site 718271003129 arginine finger; other site 718271003130 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 718271003131 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 718271003132 flagellar assembly protein FliW; Provisional; Region: PRK13282 718271003133 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 718271003134 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 718271003135 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 718271003136 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 718271003137 active site 718271003138 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 718271003139 active site 718271003140 thiamine phosphate binding site [chemical binding]; other site 718271003141 pyrophosphate binding site [ion binding]; other site 718271003142 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 718271003143 substrate binding site [chemical binding]; other site 718271003144 dimer interface [polypeptide binding]; other site 718271003145 ATP binding site [chemical binding]; other site 718271003146 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 718271003147 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 718271003148 minor groove reading motif; other site 718271003149 helix-hairpin-helix signature motif; other site 718271003150 active site 718271003151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271003152 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 718271003153 Walker A motif; other site 718271003154 ATP binding site [chemical binding]; other site 718271003155 Walker B motif; other site 718271003156 arginine finger; other site 718271003157 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 718271003158 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 718271003159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718271003160 ATP binding site [chemical binding]; other site 718271003161 putative Mg++ binding site [ion binding]; other site 718271003162 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718271003163 nucleotide binding region [chemical binding]; other site 718271003164 ATP-binding site [chemical binding]; other site 718271003165 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 718271003166 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 718271003167 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 718271003168 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 718271003169 Peptidase family M23; Region: Peptidase_M23; pfam01551 718271003170 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 718271003171 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718271003172 Lipopolysaccharide-assembly; Region: LptE; pfam04390 718271003173 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 718271003174 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 718271003175 HIGH motif; other site 718271003176 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 718271003177 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 718271003178 active site 718271003179 KMSKS motif; other site 718271003180 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 718271003181 tRNA binding surface [nucleotide binding]; other site 718271003182 anticodon binding site; other site 718271003183 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 718271003184 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 718271003185 Protein export membrane protein; Region: SecD_SecF; pfam02355 718271003186 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 718271003187 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 718271003188 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 718271003189 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 718271003190 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 718271003191 active site 718271003192 catalytic triad [active] 718271003193 dimer interface [polypeptide binding]; other site 718271003194 S-adenosylmethionine synthetase; Validated; Region: PRK05250 718271003195 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 718271003196 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 718271003197 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 718271003198 Na+/serine symporter [Amino acid transport and metabolism]; Region: SstT; COG3633 718271003199 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718271003200 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 718271003201 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 718271003202 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 718271003203 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 718271003204 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 718271003205 active site 718271003206 Zn binding site [ion binding]; other site 718271003207 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 718271003208 Part of AAA domain; Region: AAA_19; pfam13245 718271003209 Family description; Region: UvrD_C_2; pfam13538 718271003210 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04099 718271003211 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 718271003212 active site 718271003213 RNA-binding global regulator CsrA [Signal transduction mechanisms]; Region: CsrA; COG1551 718271003214 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 718271003215 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 718271003216 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 718271003217 SmpB-tmRNA interface; other site 718271003218 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 718271003219 catalytic residues [active] 718271003220 Uncharacterized conserved protein [Function unknown]; Region: COG2127 718271003221 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 718271003222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271003223 Walker A motif; other site 718271003224 ATP binding site [chemical binding]; other site 718271003225 Walker B motif; other site 718271003226 arginine finger; other site 718271003227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271003228 Walker A motif; other site 718271003229 ATP binding site [chemical binding]; other site 718271003230 Walker B motif; other site 718271003231 arginine finger; other site 718271003232 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 718271003233 Leu/Phe-tRNA-protein transferase [Posttranslational modification, protein turnover, chaperones]; Region: Aat; COG2360 718271003234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718271003235 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 718271003236 putative active site [active] 718271003237 heme pocket [chemical binding]; other site 718271003238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718271003239 putative active site [active] 718271003240 heme pocket [chemical binding]; other site 718271003241 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718271003242 dimer interface [polypeptide binding]; other site 718271003243 putative CheW interface [polypeptide binding]; other site 718271003244 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 718271003245 methionine sulfoxide reductase B; Provisional; Region: PRK05508 718271003246 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 718271003247 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 718271003248 dinuclear metal binding motif [ion binding]; other site 718271003249 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 718271003250 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 718271003251 Phosphatidylserine decarboxylase [Lipid metabolism]; Region: Psd; COG0688 718271003252 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 718271003253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271003254 Walker A motif; other site 718271003255 ATP binding site [chemical binding]; other site 718271003256 Walker B motif; other site 718271003257 arginine finger; other site 718271003258 Peptidase family M41; Region: Peptidase_M41; pfam01434 718271003259 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 718271003260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718271003261 S-adenosylmethionine binding site [chemical binding]; other site 718271003262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718271003263 Response regulator receiver domain; Region: Response_reg; pfam00072 718271003264 active site 718271003265 phosphorylation site [posttranslational modification] 718271003266 intermolecular recognition site; other site 718271003267 dimerization interface [polypeptide binding]; other site 718271003268 Cache domain; Region: Cache_1; pfam02743 718271003269 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 718271003270 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 718271003271 NAD(P) binding site [chemical binding]; other site 718271003272 homodimer interface [polypeptide binding]; other site 718271003273 substrate binding site [chemical binding]; other site 718271003274 active site 718271003275 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 718271003276 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 718271003277 inhibitor-cofactor binding pocket; inhibition site 718271003278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271003279 catalytic residue [active] 718271003280 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 718271003281 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 718271003282 putative trimer interface [polypeptide binding]; other site 718271003283 putative CoA binding site [chemical binding]; other site 718271003284 Bacterial sugar transferase; Region: Bac_transf; pfam02397 718271003285 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718271003286 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 718271003287 putative ADP-binding pocket [chemical binding]; other site 718271003288 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 718271003289 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718271003290 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 718271003291 putative ADP-binding pocket [chemical binding]; other site 718271003292 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 718271003293 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 718271003294 active site 718271003295 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718271003296 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 718271003297 putative ADP-binding pocket [chemical binding]; other site 718271003298 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 718271003299 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 718271003300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718271003301 Walker A/P-loop; other site 718271003302 ATP binding site [chemical binding]; other site 718271003303 Q-loop/lid; other site 718271003304 ABC transporter signature motif; other site 718271003305 Walker B; other site 718271003306 D-loop; other site 718271003307 H-loop/switch region; other site 718271003308 UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179 718271003309 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 718271003310 NAD binding site [chemical binding]; other site 718271003311 homodimer interface [polypeptide binding]; other site 718271003312 active site 718271003313 substrate binding site [chemical binding]; other site 718271003314 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 718271003315 active site 718271003316 catalytic site [active] 718271003317 substrate binding site [chemical binding]; other site 718271003318 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 718271003319 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 718271003320 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 718271003321 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 718271003322 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 718271003323 putative active site [active] 718271003324 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 718271003325 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 718271003326 putative acyl-acceptor binding pocket; other site 718271003327 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 718271003328 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 718271003329 putative metal binding site; other site 718271003330 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 718271003331 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 718271003332 Substrate binding site; other site 718271003333 metal-binding site 718271003334 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 718271003335 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 718271003336 active site 718271003337 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 718271003338 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 718271003339 active site 718271003340 Beta-1,3-galactosyltransferase / Beta-1,4-galactosyltransferase 718271003341 hypothetical protein 718271003342 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 718271003343 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 718271003344 active site 718271003345 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 718271003346 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 718271003347 putative active site [active] 718271003348 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 718271003349 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 718271003350 dimer interface [polypeptide binding]; other site 718271003351 active site 718271003352 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 718271003353 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 718271003354 putative ribose interaction site [chemical binding]; other site 718271003355 putative ADP binding site [chemical binding]; other site 718271003356 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 718271003357 active site 718271003358 nucleotide binding site [chemical binding]; other site 718271003359 HIGH motif; other site 718271003360 KMSKS motif; other site 718271003361 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 718271003362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718271003363 NAD(P) binding site [chemical binding]; other site 718271003364 active site 718271003365 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 718271003366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718271003367 active site 718271003368 motif I; other site 718271003369 motif II; other site 718271003370 Cytochrome c553 [Energy production and conversion]; Region: COG2863 718271003371 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 718271003372 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 718271003373 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 718271003374 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 718271003375 metal-binding site [ion binding] 718271003376 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 718271003377 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718271003378 motif II; other site 718271003379 transcription termination factor Rho; Provisional; Region: rho; PRK09376 718271003380 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 718271003381 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 718271003382 RNA binding site [nucleotide binding]; other site 718271003383 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 718271003384 multimer interface [polypeptide binding]; other site 718271003385 Walker A motif; other site 718271003386 ATP binding site [chemical binding]; other site 718271003387 Walker B motif; other site 718271003388 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08451 718271003389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271003390 Walker A motif; other site 718271003391 ATP binding site [chemical binding]; other site 718271003392 DNA polymerase III subunit delta'; Validated; Region: PRK08485 718271003393 Walker B motif; other site 718271003394 Predicted small integral membrane protein [Function unknown]; Region: COG5472 718271003395 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 718271003396 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 718271003397 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 718271003398 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 718271003399 metal-binding site [ion binding] 718271003400 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 718271003401 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 718271003402 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 718271003403 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 718271003404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 718271003405 Uncharacterized conserved protein [Function unknown]; Region: COG3610 718271003406 Uncharacterized conserved protein [Function unknown]; Region: COG2966 718271003407 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 718271003408 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 718271003409 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 718271003410 NAD binding site [chemical binding]; other site 718271003411 dimer interface [polypeptide binding]; other site 718271003412 tetramer (dimer of dimers) interface [polypeptide binding]; other site 718271003413 substrate binding site [chemical binding]; other site 718271003414 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 718271003415 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 718271003416 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 718271003417 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 718271003418 active site 718271003419 hypothetical protein; Provisional; Region: PRK12378 718271003420 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 718271003421 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 718271003422 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 718271003423 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 718271003424 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 718271003425 active site 718271003426 HIGH motif; other site 718271003427 KMSK motif region; other site 718271003428 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 718271003429 tRNA binding surface [nucleotide binding]; other site 718271003430 anticodon binding site; other site 718271003431 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 718271003432 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 718271003433 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 718271003434 catalytic site [active] 718271003435 G-X2-G-X-G-K; other site 718271003436 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 718271003437 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 718271003438 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 718271003439 Walker A/P-loop; other site 718271003440 ATP binding site [chemical binding]; other site 718271003441 Q-loop/lid; other site 718271003442 ABC transporter signature motif; other site 718271003443 Walker B; other site 718271003444 D-loop; other site 718271003445 H-loop/switch region; other site 718271003446 elongation factor Ts; Provisional; Region: tsf; PRK09377 718271003447 UBA/TS-N domain; Region: UBA; pfam00627 718271003448 Elongation factor TS; Region: EF_TS; pfam00889 718271003449 Elongation factor TS; Region: EF_TS; pfam00889 718271003450 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 718271003451 rRNA interaction site [nucleotide binding]; other site 718271003452 S8 interaction site; other site 718271003453 putative laminin-1 binding site; other site 718271003454 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 718271003455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718271003456 S-adenosylmethionine binding site [chemical binding]; other site 718271003457 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 718271003458 Cytochrome c; Region: Cytochrom_C; pfam00034 718271003459 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 718271003460 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 718271003461 intrachain domain interface; other site 718271003462 interchain domain interface [polypeptide binding]; other site 718271003463 heme bH binding site [chemical binding]; other site 718271003464 Qi binding site; other site 718271003465 heme bL binding site [chemical binding]; other site 718271003466 Qo binding site; other site 718271003467 interchain domain interface [polypeptide binding]; other site 718271003468 intrachain domain interface; other site 718271003469 Qi binding site; other site 718271003470 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 718271003471 Qo binding site; other site 718271003472 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 718271003473 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 718271003474 [2Fe-2S] cluster binding site [ion binding]; other site 718271003475 arsenical pump membrane protein; Provisional; Region: PRK15445 718271003476 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 718271003477 transmembrane helices; other site 718271003478 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 718271003479 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 718271003480 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 718271003481 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718271003482 PAS domain; Region: PAS_9; pfam13426 718271003483 putative active site [active] 718271003484 heme pocket [chemical binding]; other site 718271003485 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718271003486 dimer interface [polypeptide binding]; other site 718271003487 putative CheW interface [polypeptide binding]; other site 718271003488 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718271003489 PAS domain; Region: PAS_9; pfam13426 718271003490 putative active site [active] 718271003491 heme pocket [chemical binding]; other site 718271003492 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718271003493 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 718271003494 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 718271003495 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 718271003496 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 718271003497 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 718271003498 dihydroorotase; Provisional; Region: PRK08417 718271003499 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 718271003500 active site 718271003501 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 718271003502 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 718271003503 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 718271003504 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 718271003505 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 718271003506 GatB domain; Region: GatB_Yqey; smart00845 718271003507 S-ribosylhomocysteinase; Provisional; Region: PRK02260 718271003508 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 718271003509 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 718271003510 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 718271003511 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 718271003512 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 718271003513 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 718271003514 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 718271003515 THF binding site; other site 718271003516 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 718271003517 substrate binding site [chemical binding]; other site 718271003518 THF binding site; other site 718271003519 zinc-binding site [ion binding]; other site 718271003520 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 718271003521 FAD binding site [chemical binding]; other site 718271003522 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 718271003523 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 718271003524 DNA repair protein RadA; Provisional; Region: PRK11823 718271003525 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 718271003526 Walker A motif; other site 718271003527 ATP binding site [chemical binding]; other site 718271003528 Walker B motif; other site 718271003529 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 718271003530 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 718271003531 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 718271003532 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 718271003533 P loop; other site 718271003534 GTP binding site [chemical binding]; other site 718271003535 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 718271003536 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 718271003537 catalytic residues [active] 718271003538 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 718271003539 phosphodiesterase; Provisional; Region: PRK12704 718271003540 KH domain; Region: KH_1; pfam00013 718271003541 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 718271003542 Zn2+ binding site [ion binding]; other site 718271003543 Mg2+ binding site [ion binding]; other site 718271003544 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 718271003545 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 718271003546 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 718271003547 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 718271003548 FAD binding domain; Region: FAD_binding_4; pfam01565 718271003549 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 718271003550 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 718271003551 Peptidase family M23; Region: Peptidase_M23; pfam01551 718271003552 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 718271003553 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 718271003554 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 718271003555 Lumazine binding domain; Region: Lum_binding; pfam00677 718271003556 Lumazine binding domain; Region: Lum_binding; pfam00677 718271003557 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 718271003558 oligomerisation interface [polypeptide binding]; other site 718271003559 mobile loop; other site 718271003560 roof hairpin; other site 718271003561 chaperonin GroL; Region: GroEL; TIGR02348 718271003562 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 718271003563 ring oligomerisation interface [polypeptide binding]; other site 718271003564 ATP/Mg binding site [chemical binding]; other site 718271003565 stacking interactions; other site 718271003566 hinge regions; other site 718271003567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 718271003568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718271003569 dimer interface [polypeptide binding]; other site 718271003570 phosphorylation site [posttranslational modification] 718271003571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718271003572 ATP binding site [chemical binding]; other site 718271003573 Mg2+ binding site [ion binding]; other site 718271003574 G-X-G motif; other site 718271003575 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 718271003576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718271003577 active site 718271003578 phosphorylation site [posttranslational modification] 718271003579 intermolecular recognition site; other site 718271003580 dimerization interface [polypeptide binding]; other site 718271003581 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 718271003582 DNA binding site [nucleotide binding] 718271003583 Hemerythrin; Region: Hemerythrin; cd12107 718271003584 Fe binding site [ion binding]; other site 718271003585 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 718271003586 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 718271003587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718271003588 dimer interface [polypeptide binding]; other site 718271003589 phosphorylation site [posttranslational modification] 718271003590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718271003591 ATP binding site [chemical binding]; other site 718271003592 Mg2+ binding site [ion binding]; other site 718271003593 G-X-G motif; other site 718271003594 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 718271003595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718271003596 active site 718271003597 phosphorylation site [posttranslational modification] 718271003598 intermolecular recognition site; other site 718271003599 dimerization interface [polypeptide binding]; other site 718271003600 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718271003601 DNA binding site [nucleotide binding] 718271003602 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 718271003603 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 718271003604 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 718271003605 protein binding site [polypeptide binding]; other site 718271003606 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 718271003607 protein binding site [polypeptide binding]; other site 718271003608 chaperone protein DnaJ; Provisional; Region: PRK14299 718271003609 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 718271003610 HSP70 interaction site [polypeptide binding]; other site 718271003611 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 718271003612 substrate binding site [polypeptide binding]; other site 718271003613 dimer interface [polypeptide binding]; other site 718271003614 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 718271003615 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 718271003616 DNA binding residues [nucleotide binding] 718271003617 putative dimer interface [polypeptide binding]; other site 718271003618 Glutathione-regulated potassium-efflux system protein kefB 718271003619 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 718271003620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718271003621 motif II; other site 718271003622 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 718271003623 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 718271003624 Peptidase family M23; Region: Peptidase_M23; pfam01551 718271003625 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 718271003626 exopolyphosphatase; Region: exo_poly_only; TIGR03706 718271003627 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 718271003628 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 718271003629 active site 718271003630 hydrophilic channel; other site 718271003631 dimerization interface [polypeptide binding]; other site 718271003632 catalytic residues [active] 718271003633 active site lid [active] 718271003634 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946 718271003635 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 718271003636 potential frameshift: common BLAST hit: gi|218562852|ref|YP_002344631.1| periplasmic protein 718271003637 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 718271003638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271003639 putative substrate translocation pore; other site 718271003640 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 718271003641 substrate binding site [chemical binding]; other site 718271003642 active site 718271003643 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 718271003644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718271003645 FeS/SAM binding site; other site 718271003646 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 718271003647 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 718271003648 GIY-YIG motif/motif A; other site 718271003649 active site 718271003650 catalytic site [active] 718271003651 putative DNA binding site [nucleotide binding]; other site 718271003652 metal binding site [ion binding]; metal-binding site 718271003653 UvrB/uvrC motif; Region: UVR; pfam02151 718271003654 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 718271003655 GMP synthase; Reviewed; Region: guaA; PRK00074 718271003656 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 718271003657 AMP/PPi binding site [chemical binding]; other site 718271003658 candidate oxyanion hole; other site 718271003659 catalytic triad [active] 718271003660 potential glutamine specificity residues [chemical binding]; other site 718271003661 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 718271003662 ATP Binding subdomain [chemical binding]; other site 718271003663 Ligand Binding sites [chemical binding]; other site 718271003664 Dimerization subdomain; other site 718271003665 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 718271003666 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 718271003667 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 718271003668 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 718271003669 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 718271003670 Predicted membrane protein/domain [Function unknown]; Region: COG1714 718271003671 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 718271003672 Organic solvent tolerance protein; Region: OstA_C; pfam04453 718271003673 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 718271003674 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 718271003675 oligomer interface [polypeptide binding]; other site 718271003676 RNA binding site [nucleotide binding]; other site 718271003677 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 718271003678 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 718271003679 RNase E interface [polypeptide binding]; other site 718271003680 trimer interface [polypeptide binding]; other site 718271003681 active site 718271003682 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 718271003683 putative nucleic acid binding region [nucleotide binding]; other site 718271003684 G-X-X-G motif; other site 718271003685 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 718271003686 RNA binding site [nucleotide binding]; other site 718271003687 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 718271003688 putative active site [active] 718271003689 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 718271003690 drug efflux system protein MdtG; Provisional; Region: PRK09874 718271003691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271003692 putative substrate translocation pore; other site 718271003693 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 718271003694 Low molecular weight phosphatase family; Region: LMWPc; cd00115 718271003695 active site 718271003696 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 718271003697 chaperone protein DnaJ; Provisional; Region: PRK10767 718271003698 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 718271003699 HSP70 interaction site [polypeptide binding]; other site 718271003700 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 718271003701 substrate binding site [polypeptide binding]; other site 718271003702 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 718271003703 Zn binding sites [ion binding]; other site 718271003704 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 718271003705 dimer interface [polypeptide binding]; other site 718271003706 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 718271003707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718271003708 active site 718271003709 phosphorylation site [posttranslational modification] 718271003710 intermolecular recognition site; other site 718271003711 dimerization interface [polypeptide binding]; other site 718271003712 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718271003713 DNA binding site [nucleotide binding] 718271003714 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 718271003715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718271003716 dimer interface [polypeptide binding]; other site 718271003717 phosphorylation site [posttranslational modification] 718271003718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718271003719 ATP binding site [chemical binding]; other site 718271003720 Mg2+ binding site [ion binding]; other site 718271003721 G-X-G motif; other site 718271003722 recombination protein RecR; Reviewed; Region: recR; PRK00076 718271003723 RecR protein; Region: RecR; pfam02132 718271003724 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 718271003725 active site 718271003726 metal binding site [ion binding]; metal-binding site 718271003727 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 718271003728 nickel binding site [ion binding]; other site 718271003729 putative substrate-binding site; other site 718271003730 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 718271003731 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 718271003732 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 718271003733 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 718271003734 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 718271003735 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 718271003736 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 718271003737 Uncharacterized conserved protein [Function unknown]; Region: COG4121 718271003738 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 718271003739 AMIN domain; Region: AMIN; pfam11741 718271003740 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 718271003741 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 718271003742 active site 718271003743 metal binding site [ion binding]; metal-binding site 718271003744 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 718271003745 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 718271003746 FMN binding site [chemical binding]; other site 718271003747 substrate binding site [chemical binding]; other site 718271003748 putative catalytic residue [active] 718271003749 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 718271003750 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 718271003751 active site 718271003752 HIGH motif; other site 718271003753 dimer interface [polypeptide binding]; other site 718271003754 KMSKS motif; other site 718271003755 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 718271003756 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 718271003757 Zn2+ binding site [ion binding]; other site 718271003758 Mg2+ binding site [ion binding]; other site 718271003759 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 718271003760 synthetase active site [active] 718271003761 NTP binding site [chemical binding]; other site 718271003762 metal binding site [ion binding]; metal-binding site 718271003763 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 718271003764 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 718271003765 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 718271003766 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 718271003767 putative nucleotide binding site [chemical binding]; other site 718271003768 uridine monophosphate binding site [chemical binding]; other site 718271003769 homohexameric interface [polypeptide binding]; other site 718271003770 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 718271003771 Peptidase family M23; Region: Peptidase_M23; pfam01551 718271003772 FtsX-like permease family; Region: FtsX; pfam02687 718271003773 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 718271003774 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 718271003775 Walker A/P-loop; other site 718271003776 ATP binding site [chemical binding]; other site 718271003777 Q-loop/lid; other site 718271003778 ABC transporter signature motif; other site 718271003779 Walker B; other site 718271003780 D-loop; other site 718271003781 H-loop/switch region; other site 718271003782 tRNA (guanine-N(7)-)-methyltransferase; Provisional; Region: PRK14121 718271003783 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 718271003784 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 718271003785 Interdomain contacts; other site 718271003786 Cytokine receptor motif; other site 718271003787 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 718271003788 Interdomain contacts; other site 718271003789 Cytokine receptor motif; other site 718271003790 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 718271003791 Interdomain contacts; other site 718271003792 Cytokine receptor motif; other site 718271003793 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 718271003794 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718271003795 RNA binding surface [nucleotide binding]; other site 718271003796 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 718271003797 active site 718271003798 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 718271003799 integrase; Provisional; Region: PRK09692 718271003800 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 718271003801 active site 718271003802 Int/Topo IB signature motif; other site 718271003803 Helix-turn-helix domain; Region: HTH_17; pfam12728 718271003804 DNA methylase; Region: N6_N4_Mtase; pfam01555 718271003805 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 718271003806 Replication initiation factor; Region: Rep_trans; pfam02486 718271003807 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 718271003808 non-specific DNA binding site [nucleotide binding]; other site 718271003809 salt bridge; other site 718271003810 sequence-specific DNA binding site [nucleotide binding]; other site 718271003811 YopX protein; Region: YopX; pfam09643 718271003812 potential frameshift: common BLAST hit: gi|57238171|ref|YP_179421.1| DNA-binding protein Roi 718271003813 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 718271003814 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 718271003815 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 718271003816 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 718271003817 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 718271003818 active site 718271003819 catalytic site [active] 718271003820 substrate binding site [chemical binding]; other site 718271003821 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 718271003822 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 718271003823 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 718271003824 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 718271003825 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 718271003826 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 718271003827 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 718271003828 Phage capsid family; Region: Phage_capsid; pfam05065 718271003829 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 718271003830 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 718271003831 Minor capsid protein; Region: Minor_capsid_2; pfam11114 718271003832 Phage portal protein; Region: Phage_portal; pfam04860 718271003833 Phage-related protein [Function unknown]; Region: COG4695 718271003834 PemK-like protein; Region: PemK; pfam02452 718271003835 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 718271003836 Phage terminase, small subunit; Region: Terminase_4; cl01525 718271003837 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 718271003838 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 718271003839 active site 718271003840 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 718271003841 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 718271003842 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 718271003843 TrkA-N domain; Region: TrkA_N; pfam02254 718271003844 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 718271003845 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718271003846 active site 718271003847 Malic enzyme, N-terminal domain; Region: malic; pfam00390 718271003848 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 718271003849 putative NAD(P) binding site [chemical binding]; other site 718271003850 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 718271003851 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 718271003852 active site 718271003853 HIGH motif; other site 718271003854 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 718271003855 active site 718271003856 KMSKS motif; other site 718271003857 SurA N-terminal domain; Region: SurA_N; pfam09312 718271003858 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 718271003859 biotin carboxylase; Validated; Region: PRK08462 718271003860 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 718271003861 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 718271003862 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 718271003863 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 718271003864 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 718271003865 carboxyltransferase (CT) interaction site; other site 718271003866 biotinylation site [posttranslational modification]; other site 718271003867 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 718271003868 trimer interface [polypeptide binding]; other site 718271003869 active site 718271003870 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 718271003871 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 718271003872 NAD(P) binding site [chemical binding]; other site 718271003873 homodimer interface [polypeptide binding]; other site 718271003874 substrate binding site [chemical binding]; other site 718271003875 active site 718271003876 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 718271003877 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 718271003878 inhibitor-cofactor binding pocket; inhibition site 718271003879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271003880 catalytic residue [active] 718271003881 hypothetical protein 718271003882 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 718271003883 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 718271003884 Methyltransferase domain; Region: Methyltransf_23; pfam13489 718271003885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718271003886 S-adenosylmethionine binding site [chemical binding]; other site 718271003887 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 718271003888 HAD-superfamily phosphatase, subfamily IIIC; Region: HAD-SF-IIIC; TIGR01681 718271003889 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12880 718271003890 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 718271003891 dimer interface [polypeptide binding]; other site 718271003892 active site 718271003893 CoA binding pocket [chemical binding]; other site 718271003894 Phosphopantetheine attachment site; Region: PP-binding; cl09936 718271003895 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 718271003896 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 718271003897 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 718271003898 acyl-activating enzyme (AAE) consensus motif; other site 718271003899 AMP binding site [chemical binding]; other site 718271003900 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 718271003901 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 718271003902 active site 718271003903 cosubstrate binding site; other site 718271003904 substrate binding site [chemical binding]; other site 718271003905 catalytic site [active] 718271003906 polysaccharide deacetylase family protein 718271003907 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 718271003908 hypothetical protein 718271003909 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 718271003910 ligand binding site; other site 718271003911 tetramer interface; other site 718271003912 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 718271003913 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 718271003914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718271003915 Coenzyme A binding pocket [chemical binding]; other site 718271003916 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 718271003917 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 718271003918 substrate binding site [chemical binding]; other site 718271003919 glutamase interaction surface [polypeptide binding]; other site 718271003920 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 718271003921 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 718271003922 putative active site [active] 718271003923 oxyanion strand; other site 718271003924 catalytic triad [active] 718271003925 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 718271003926 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 718271003927 Ligand Binding Site [chemical binding]; other site 718271003928 pseudaminic acid synthase; Region: PseI; TIGR03586 718271003929 NeuB family; Region: NeuB; pfam03102 718271003930 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 718271003931 NeuB binding interface [polypeptide binding]; other site 718271003932 putative substrate binding site [chemical binding]; other site 718271003933 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 718271003934 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 718271003935 NAD binding site [chemical binding]; other site 718271003936 substrate binding site [chemical binding]; other site 718271003937 active site 718271003938 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 718271003939 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 718271003940 inhibitor-cofactor binding pocket; inhibition site 718271003941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271003942 catalytic residue [active] 718271003943 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 718271003944 substrate binding site [chemical binding]; other site 718271003945 active site 718271003946 cosubstrate binding site; other site 718271003947 catalytic site [active] 718271003948 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 718271003949 NeuB family; Region: NeuB; pfam03102 718271003950 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 718271003951 NeuB binding interface [polypeptide binding]; other site 718271003952 putative substrate binding site [chemical binding]; other site 718271003953 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 718271003954 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 718271003955 active site 718271003956 homodimer interface [polypeptide binding]; other site 718271003957 FOG: CBS domain [General function prediction only]; Region: COG0517 718271003958 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 718271003959 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 718271003960 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 718271003961 Substrate binding site; other site 718271003962 metal-binding site 718271003963 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 718271003964 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 718271003965 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 718271003966 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 718271003967 ligand binding site; other site 718271003968 tetramer interface; other site 718271003969 flagellin modification protein A; Provisional; Region: PRK09186 718271003970 classical (c) SDR, subgroup 8; Region: SDR_c8; cd08930 718271003971 putative NAD(P) binding site [chemical binding]; other site 718271003972 active site 718271003973 motility accessory factor 718271003974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 718271003975 conserved hypothetical protein 718271003976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 718271003977 flagellin; Reviewed; Region: PRK08411 718271003978 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 718271003979 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 718271003980 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 718271003981 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 718271003982 flagellin; Reviewed; Region: PRK08411 718271003983 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 718271003984 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 718271003985 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 718271003986 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 718271003987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 718271003988 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 718271003989 UGMP family protein; Validated; Region: PRK09604 718271003990 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 718271003991 Putative periplasmic protein 718271003992 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 718271003993 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 718271003994 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 718271003995 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 718271003996 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 718271003997 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 718271003998 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 718271003999 Domain of unknown function (DUF814); Region: DUF814; pfam05670 718271004000 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 718271004001 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 718271004002 GTP binding site; other site 718271004003 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 718271004004 dimerization interface [polypeptide binding]; other site 718271004005 substrate binding site [chemical binding]; other site 718271004006 active site 718271004007 calcium binding site [ion binding]; other site 718271004008 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 718271004009 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718271004010 ABC-ATPase subunit interface; other site 718271004011 dimer interface [polypeptide binding]; other site 718271004012 putative PBP binding regions; other site 718271004013 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 718271004014 ABC-ATPase subunit interface; other site 718271004015 dimer interface [polypeptide binding]; other site 718271004016 putative PBP binding regions; other site 718271004017 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 718271004018 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 718271004019 Walker A/P-loop; other site 718271004020 ATP binding site [chemical binding]; other site 718271004021 Q-loop/lid; other site 718271004022 ABC transporter signature motif; other site 718271004023 Walker B; other site 718271004024 D-loop; other site 718271004025 H-loop/switch region; other site 718271004026 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 718271004027 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 718271004028 putative ligand binding residues [chemical binding]; other site 718271004029 Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit [Inorganic ion transport and metabolism]; Region: NrfA; COG3303 718271004030 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 718271004031 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 718271004032 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 718271004033 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 718271004034 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 718271004035 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 718271004036 putative domain interface [polypeptide binding]; other site 718271004037 putative active site [active] 718271004038 catalytic site [active] 718271004039 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 718271004040 putative domain interface [polypeptide binding]; other site 718271004041 putative active site [active] 718271004042 catalytic site [active] 718271004043 potential frameshift: common BLAST hit: gi|315124800|ref|YP_004066804.1| vacuolating cytotoxin precursor 718271004044 Autotransporter beta-domain; Region: Autotransporter; smart00869 718271004045 potential frameshift: common BLAST hit: gi|315124800|ref|YP_004066804.1| vacuolating cytotoxin precursor 718271004046 potential frameshift: common BLAST hit: gi|315124800|ref|YP_004066804.1| vacuolating cytotoxin precursor 718271004047 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 718271004048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271004049 Walker A motif; other site 718271004050 ATP binding site [chemical binding]; other site 718271004051 Walker B motif; other site 718271004052 arginine finger; other site 718271004053 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 718271004054 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 718271004055 Domain of unknown function DUF20; Region: UPF0118; pfam01594 718271004056 fumarate hydratase; Reviewed; Region: fumC; PRK00485 718271004057 Class II fumarases; Region: Fumarase_classII; cd01362 718271004058 active site 718271004059 tetramer interface [polypeptide binding]; other site 718271004060 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 718271004061 catalytic triad [active] 718271004062 putative active site [active] 718271004063 autotransporter-associated beta strand repeat; Region: autotrns_rpt; TIGR02601 718271004064 Autotransporter beta-domain; Region: Autotransporter; pfam03797 718271004065 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 718271004066 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 718271004067 glutaminase active site [active] 718271004068 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 718271004069 dimer interface [polypeptide binding]; other site 718271004070 active site 718271004071 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 718271004072 dimer interface [polypeptide binding]; other site 718271004073 active site 718271004074 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 718271004075 hypothetical protein; Provisional; Region: PRK08444 718271004076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718271004077 FeS/SAM binding site; other site 718271004078 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 718271004079 Sulfate transporter family; Region: Sulfate_transp; pfam00916 718271004080 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 718271004081 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718271004082 active site 718271004083 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 718271004084 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 718271004085 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 718271004086 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 718271004087 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 718271004088 active site 718271004089 dimerization interface [polypeptide binding]; other site 718271004090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271004091 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718271004092 putative substrate translocation pore; other site 718271004093 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 718271004094 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 718271004095 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 718271004096 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 718271004097 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 718271004098 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 718271004099 G1 box; other site 718271004100 putative GEF interaction site [polypeptide binding]; other site 718271004101 GTP/Mg2+ binding site [chemical binding]; other site 718271004102 Switch I region; other site 718271004103 G2 box; other site 718271004104 G3 box; other site 718271004105 Switch II region; other site 718271004106 G4 box; other site 718271004107 G5 box; other site 718271004108 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 718271004109 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 718271004110 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 718271004111 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 718271004112 flavodoxin FldA; Validated; Region: PRK09267 718271004113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4378 718271004114 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 718271004115 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 718271004116 tetramer interface [polypeptide binding]; other site 718271004117 heme binding pocket [chemical binding]; other site 718271004118 NADPH binding site [chemical binding]; other site 718271004119 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 718271004120 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 718271004121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 718271004122 YheO-like PAS domain; Region: PAS_6; pfam08348 718271004123 HTH domain; Region: HTH_22; pfam13309 718271004124 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 718271004125 homotrimer interaction site [polypeptide binding]; other site 718271004126 putative active site [active] 718271004127 Anaerobic C4-dicarboxylate transporter DcuC 718271004128 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 718271004129 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 718271004130 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718271004131 catalytic residue [active] 718271004132 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 718271004133 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 718271004134 tetramer interface [polypeptide binding]; other site 718271004135 active site 718271004136 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 718271004137 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 718271004138 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 718271004139 G1 box; other site 718271004140 GTP/Mg2+ binding site [chemical binding]; other site 718271004141 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 718271004142 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 718271004143 G2 box; other site 718271004144 Switch I region; other site 718271004145 G3 box; other site 718271004146 Switch II region; other site 718271004147 GTP/Mg2+ binding site [chemical binding]; other site 718271004148 G4 box; other site 718271004149 G5 box; other site 718271004150 Nucleoside recognition; Region: Gate; pfam07670 718271004151 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 718271004152 Nucleoside recognition; Region: Gate; pfam07670 718271004153 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 718271004154 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 718271004155 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415 718271004156 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 718271004157 NAD binding site [chemical binding]; other site 718271004158 homotetramer interface [polypeptide binding]; other site 718271004159 homodimer interface [polypeptide binding]; other site 718271004160 substrate binding site [chemical binding]; other site 718271004161 active site 718271004162 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 718271004163 triosephosphate isomerase; Provisional; Region: PRK14565 718271004164 substrate binding site [chemical binding]; other site 718271004165 dimer interface [polypeptide binding]; other site 718271004166 catalytic triad [active] 718271004167 Phosphoglycerate kinase; Region: PGK; pfam00162 718271004168 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 718271004169 substrate binding site [chemical binding]; other site 718271004170 hinge regions; other site 718271004171 ADP binding site [chemical binding]; other site 718271004172 catalytic site [active] 718271004173 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 718271004174 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 718271004175 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 718271004176 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 718271004177 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 718271004178 active site 718271004179 (T/H)XGH motif; other site 718271004180 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 718271004181 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 718271004182 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 718271004183 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 718271004184 active site 718271004185 substrate binding site [chemical binding]; other site 718271004186 metal binding site [ion binding]; metal-binding site 718271004187 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK08455 718271004188 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 718271004189 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 718271004190 Cytochrome P450; Region: p450; cl12078 718271004191 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 718271004192 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 718271004193 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 718271004194 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 718271004195 Ligand binding site; other site 718271004196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 718271004197 active site 718271004198 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 718271004199 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 718271004200 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 718271004201 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 718271004202 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 718271004203 active site 718271004204 catalytic site [active] 718271004205 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 718271004206 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 718271004207 Substrate binding site; other site 718271004208 Mg++ binding site; other site 718271004209 metal-binding site 718271004210 Mg++ binding site; other site 718271004211 metal-binding site 718271004212 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 718271004213 dimer interface [polypeptide binding]; other site 718271004214 active site 718271004215 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 718271004216 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 718271004217 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 718271004218 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 718271004219 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 718271004220 NADP-binding site; other site 718271004221 homotetramer interface [polypeptide binding]; other site 718271004222 substrate binding site [chemical binding]; other site 718271004223 homodimer interface [polypeptide binding]; other site 718271004224 active site 718271004225 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 718271004226 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 718271004227 NADP binding site [chemical binding]; other site 718271004228 active site 718271004229 putative substrate binding site [chemical binding]; other site 718271004230 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 718271004231 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 718271004232 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718271004233 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 718271004234 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 718271004235 KpsF/GutQ family protein; Region: kpsF; TIGR00393 718271004236 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 718271004237 putative active site [active] 718271004238 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 718271004239 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 718271004240 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 718271004241 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 718271004242 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 718271004243 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 718271004244 Walker A/P-loop; other site 718271004245 ATP binding site [chemical binding]; other site 718271004246 Q-loop/lid; other site 718271004247 ABC transporter signature motif; other site 718271004248 Walker B; other site 718271004249 D-loop; other site 718271004250 H-loop/switch region; other site 718271004251 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 718271004252 ABC-2 type transporter; Region: ABC2_membrane; cl17235 718271004253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 718271004254 dUTPase; Region: dUTPase_2; pfam08761 718271004255 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 718271004256 active site 718271004257 homodimer interface [polypeptide binding]; other site 718271004258 metal binding site [ion binding]; metal-binding site 718271004259 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 718271004260 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 718271004261 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 718271004262 Ligand Binding Site [chemical binding]; other site 718271004263 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 718271004264 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 718271004265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718271004266 FeS/SAM binding site; other site 718271004267 peptide chain release factor 2; Validated; Region: prfB; PRK00578 718271004268 This domain is found in peptide chain release factors; Region: PCRF; smart00937 718271004269 RF-1 domain; Region: RF-1; pfam00472 718271004270 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 718271004271 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 718271004272 Permutation of conserved domain; other site 718271004273 active site 718271004274 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 718271004275 thiamine monophosphate kinase; Provisional; Region: PRK05731 718271004276 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 718271004277 ATP binding site [chemical binding]; other site 718271004278 dimerization interface [polypeptide binding]; other site 718271004279 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 718271004280 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 718271004281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 718271004282 S-adenosylmethionine binding site [chemical binding]; other site 718271004283 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 718271004284 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 718271004285 Rod binding protein; Region: Rod-binding; cl01626 718271004286 FlgN protein; Region: FlgN; pfam05130 718271004287 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 718271004288 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718271004289 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 718271004290 hypothetical protein; Provisional; Region: PRK10621 718271004291 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 718271004292 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 718271004293 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 718271004294 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 718271004295 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 718271004296 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 718271004297 Walker A motif; other site 718271004298 ATP binding site [chemical binding]; other site 718271004299 Walker B motif; other site 718271004300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718271004301 AAA domain; Region: AAA_22; pfam13401 718271004302 Walker A motif; other site 718271004303 ATP binding site [chemical binding]; other site 718271004304 Walker B motif; other site 718271004305 arginine finger; other site 718271004306 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 718271004307 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 718271004308 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 718271004309 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 718271004310 dimer interface [polypeptide binding]; other site 718271004311 PYR/PP interface [polypeptide binding]; other site 718271004312 TPP binding site [chemical binding]; other site 718271004313 substrate binding site [chemical binding]; other site 718271004314 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 718271004315 Domain of unknown function; Region: EKR; pfam10371 718271004316 4Fe-4S binding domain; Region: Fer4_6; pfam12837 718271004317 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 718271004318 TPP-binding site [chemical binding]; other site 718271004319 dimer interface [polypeptide binding]; other site 718271004320 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 718271004321 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718271004322 motif II; other site 718271004323 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 718271004324 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 718271004325 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718271004326 ligand binding site [chemical binding]; other site 718271004327 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 718271004328 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 718271004329 23S rRNA interface [nucleotide binding]; other site 718271004330 L3 interface [polypeptide binding]; other site 718271004331 Part of AAA domain; Region: AAA_19; pfam13245 718271004332 putative recombination protein RecB; Provisional; Region: PRK13909 718271004333 Family description; Region: UvrD_C_2; pfam13538 718271004334 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 718271004335 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 718271004336 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 718271004337 FixH; Region: FixH; pfam05751 718271004338 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 718271004339 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 718271004340 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 718271004341 Cytochrome c; Region: Cytochrom_C; cl11414 718271004342 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 718271004343 cytochrome c oxidase, cbb3-type, CcoQ subunit, epsilon-Proteobacterial; Region: cbb3_Q_epsi; TIGR02736 718271004344 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 718271004345 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 718271004346 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 718271004347 Low-spin heme binding site [chemical binding]; other site 718271004348 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 718271004349 D-pathway; other site 718271004350 Putative water exit pathway; other site 718271004351 Binuclear center (active site) [active] 718271004352 K-pathway; other site 718271004353 Putative proton exit pathway; other site 718271004354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718271004355 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 718271004356 active site 718271004357 phosphorylation site [posttranslational modification] 718271004358 intermolecular recognition site; other site 718271004359 dimerization interface [polypeptide binding]; other site 718271004360 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718271004361 DNA binding site [nucleotide binding] 718271004362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718271004363 PAS domain; Region: PAS_9; pfam13426 718271004364 putative active site [active] 718271004365 heme pocket [chemical binding]; other site 718271004366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 718271004367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718271004368 ATP binding site [chemical binding]; other site 718271004369 Mg2+ binding site [ion binding]; other site 718271004370 G-X-G motif; other site 718271004371 Uncharacterized conserved protein [Function unknown]; Region: COG2836 718271004372 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 718271004373 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 718271004374 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 718271004375 catalytic site [active] 718271004376 subunit interface [polypeptide binding]; other site 718271004377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2952 718271004378 Uncharacterized conserved protein [Function unknown]; Region: COG3334 718271004379 Flagellar FliJ protein; Region: FliJ; pfam02050 718271004380 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 718271004381 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 718271004382 GDP-binding site [chemical binding]; other site 718271004383 ACT binding site; other site 718271004384 IMP binding site; other site 718271004385 putative inner membrane protein; Provisional; Region: PRK11099 718271004386 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 718271004387 Sulphur transport; Region: Sulf_transp; pfam04143 718271004388 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 718271004389 CPxP motif; other site 718271004390 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 718271004391 Na binding site [ion binding]; other site 718271004392 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 718271004393 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 718271004394 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 718271004395 Glutamate binding site [chemical binding]; other site 718271004396 NAD binding site [chemical binding]; other site 718271004397 catalytic residues [active] 718271004398 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 718271004399 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 718271004400 dimerization interface [polypeptide binding]; other site 718271004401 putative ATP binding site [chemical binding]; other site 718271004402 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 718271004403 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 718271004404 CPxP motif; other site 718271004405 Cache domain; Region: Cache_1; pfam02743 718271004406 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 718271004407 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718271004408 dimer interface [polypeptide binding]; other site 718271004409 putative CheW interface [polypeptide binding]; other site 718271004410 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 718271004411 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 718271004412 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 718271004413 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 718271004414 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 718271004415 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 718271004416 molybdopterin cofactor binding site; other site 718271004417 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 718271004418 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 718271004419 molybdopterin cofactor binding site; other site 718271004420 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 718271004421 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718271004422 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 718271004423 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 718271004424 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 718271004425 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 718271004426 dimer interface [polypeptide binding]; other site 718271004427 active site 718271004428 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718271004429 catalytic residues [active] 718271004430 substrate binding site [chemical binding]; other site 718271004431 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 718271004432 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 718271004433 Multicopper oxidase; Region: Cu-oxidase; pfam00394 718271004434 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 718271004435 ThiS family; Region: ThiS; pfam02597 718271004436 charged pocket; other site 718271004437 hydrophobic patch; other site 718271004438 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 718271004439 MoaE homodimer interface [polypeptide binding]; other site 718271004440 MoaD interaction [polypeptide binding]; other site 718271004441 active site residues [active] 718271004442 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 718271004443 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 718271004444 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 718271004445 dimer interface [polypeptide binding]; other site 718271004446 putative functional site; other site 718271004447 putative MPT binding site; other site 718271004448 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 718271004449 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 718271004450 CRISPR-associated protein, Csn1 family 718271004451 C4-dicarboxylate anaerobic carrier, putative 718271004452 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 718271004453 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 718271004454 dimerization interface [polypeptide binding]; other site 718271004455 putative ATP binding site [chemical binding]; other site 718271004456 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 718271004457 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 718271004458 CoA-binding site [chemical binding]; other site 718271004459 ATP-binding [chemical binding]; other site 718271004460 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 718271004461 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 718271004462 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 718271004463 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 718271004464 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 718271004465 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 718271004466 AAA domain; Region: AAA_14; pfam13173 718271004467 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 718271004468 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 718271004469 dimerization interface [polypeptide binding]; other site 718271004470 DPS ferroxidase diiron center [ion binding]; other site 718271004471 ion pore; other site 718271004472 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 718271004473 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 718271004474 active site 718271004475 dimer interface [polypeptide binding]; other site 718271004476 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 718271004477 dimer interface [polypeptide binding]; other site 718271004478 active site 718271004479 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 718271004480 active site 718271004481 tetramer interface; other site 718271004482 acetyl-CoA synthetase; Provisional; Region: PRK00174 718271004483 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 718271004484 active site 718271004485 CoA binding site [chemical binding]; other site 718271004486 acyl-activating enzyme (AAE) consensus motif; other site 718271004487 AMP binding site [chemical binding]; other site 718271004488 acetate binding site [chemical binding]; other site 718271004489 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 718271004490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718271004491 Walker A/P-loop; other site 718271004492 ATP binding site [chemical binding]; other site 718271004493 Q-loop/lid; other site 718271004494 ABC transporter signature motif; other site 718271004495 Walker B; other site 718271004496 D-loop; other site 718271004497 H-loop/switch region; other site 718271004498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271004499 dimer interface [polypeptide binding]; other site 718271004500 conserved gate region; other site 718271004501 putative PBP binding loops; other site 718271004502 ABC-ATPase subunit interface; other site 718271004503 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 718271004504 PBP superfamily domain; Region: PBP_like_2; pfam12849 718271004505 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 718271004506 putative active site [active] 718271004507 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 718271004508 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 718271004509 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 718271004510 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 718271004511 EamA-like transporter family; Region: EamA; cl17759 718271004512 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 718271004513 Predicted transcriptional regulators [Transcription]; Region: COG1733 718271004514 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 718271004515 potential frameshift: common BLAST hit: gi|218563140|ref|YP_002344919.1| Blc protein 718271004516 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 718271004517 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 718271004518 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 718271004519 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 718271004520 putative NAD(P) binding site [chemical binding]; other site 718271004521 putative substrate binding site [chemical binding]; other site 718271004522 catalytic Zn binding site [ion binding]; other site 718271004523 structural Zn binding site [ion binding]; other site 718271004524 dimer interface [polypeptide binding]; other site 718271004525 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 718271004526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 718271004527 DEAD-like helicases superfamily; Region: DEXDc; smart00487 718271004528 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718271004529 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 718271004530 putative Mg++ binding site [ion binding]; other site 718271004531 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 718271004532 AAA domain; Region: AAA_13; pfam13166 718271004533 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 718271004534 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 718271004535 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 718271004536 Fic family protein [Function unknown]; Region: COG3177 718271004537 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 718271004538 Fic/DOC family; Region: Fic; pfam02661 718271004539 HsdM N-terminal domain; Region: HsdM_N; pfam12161 718271004540 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 718271004541 Methyltransferase domain; Region: Methyltransf_26; pfam13659 718271004542 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 718271004543 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 718271004544 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 718271004545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271004546 putative substrate translocation pore; other site 718271004547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718271004548 NADH(P)-binding; Region: NAD_binding_10; pfam13460 718271004549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718271004550 NADH(P)-binding; Region: NAD_binding_10; pfam13460 718271004551 active site 718271004552 Predicted permeases [General function prediction only]; Region: COG0701 718271004553 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718271004554 dimerization interface [polypeptide binding]; other site 718271004555 putative DNA binding site [nucleotide binding]; other site 718271004556 putative Zn2+ binding site [ion binding]; other site 718271004557 Low molecular weight phosphatase family; Region: LMWPc; cl00105 718271004558 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 718271004559 Sodium Bile acid symporter family; Region: SBF; cl17470 718271004560 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 718271004561 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 718271004562 putative dimer interface [polypeptide binding]; other site 718271004563 Cache domain; Region: Cache_1; pfam02743 718271004564 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 718271004565 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718271004566 dimer interface [polypeptide binding]; other site 718271004567 putative CheW interface [polypeptide binding]; other site 718271004568 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15490 718271004569 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 718271004570 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 718271004571 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 718271004572 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 718271004573 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 718271004574 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 718271004575 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 718271004576 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713 718271004577 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 718271004578 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 718271004579 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 718271004580 4Fe-4S binding domain; Region: Fer4; cl02805 718271004581 4Fe-4S binding domain; Region: Fer4; pfam00037 718271004582 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 718271004583 NADH dehydrogenase subunit G; Validated; Region: PRK08493 718271004584 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 718271004585 catalytic loop [active] 718271004586 iron binding site [ion binding]; other site 718271004587 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 718271004588 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718271004589 NADH dehydrogenase subunit D; Validated; Region: PRK06075 718271004590 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 718271004591 NADH dehydrogenase subunit C; Provisional; Region: PRK08491 718271004592 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 718271004593 NADH dehydrogenase subunit B; Validated; Region: PRK06411 718271004594 NADH dehydrogenase subunit A; Validated; Region: PRK08489 718271004595 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 718271004596 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718271004597 Walker A/P-loop; other site 718271004598 ATP binding site [chemical binding]; other site 718271004599 Q-loop/lid; other site 718271004600 ABC transporter signature motif; other site 718271004601 Walker B; other site 718271004602 D-loop; other site 718271004603 H-loop/switch region; other site 718271004604 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718271004605 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 718271004606 Walker A/P-loop; other site 718271004607 ATP binding site [chemical binding]; other site 718271004608 Q-loop/lid; other site 718271004609 ABC transporter signature motif; other site 718271004610 Walker B; other site 718271004611 D-loop; other site 718271004612 H-loop/switch region; other site 718271004613 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 718271004614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718271004615 putative PBP binding loops; other site 718271004616 ABC-ATPase subunit interface; other site 718271004617 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 718271004618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 718271004619 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 718271004620 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 718271004621 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 718271004622 FAD binding domain; Region: FAD_binding_4; pfam01565 718271004623 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 718271004624 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 718271004625 heme-binding site [chemical binding]; other site 718271004626 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 718271004627 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 718271004628 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 718271004629 Walker A/P-loop; other site 718271004630 ATP binding site [chemical binding]; other site 718271004631 Q-loop/lid; other site 718271004632 ABC transporter signature motif; other site 718271004633 Walker B; other site 718271004634 D-loop; other site 718271004635 H-loop/switch region; other site 718271004636 metabolite-proton symporter; Region: 2A0106; TIGR00883 718271004637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271004638 putative substrate translocation pore; other site 718271004639 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 718271004640 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 718271004641 rRNA binding site [nucleotide binding]; other site 718271004642 predicted 30S ribosome binding site; other site 718271004643 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 718271004644 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 718271004645 30S ribosomal protein S13; Region: bact_S13; TIGR03631 718271004646 30S ribosomal protein S11; Validated; Region: PRK05309 718271004647 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 718271004648 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 718271004649 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718271004650 RNA binding surface [nucleotide binding]; other site 718271004651 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 718271004652 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 718271004653 alphaNTD homodimer interface [polypeptide binding]; other site 718271004654 alphaNTD - beta interaction site [polypeptide binding]; other site 718271004655 alphaNTD - beta' interaction site [polypeptide binding]; other site 718271004656 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 718271004657 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 718271004658 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 718271004659 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 718271004660 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 718271004661 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 718271004662 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 718271004663 NAD binding site [chemical binding]; other site 718271004664 dimerization interface [polypeptide binding]; other site 718271004665 product binding site; other site 718271004666 substrate binding site [chemical binding]; other site 718271004667 zinc binding site [ion binding]; other site 718271004668 catalytic residues [active] 718271004669 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 718271004670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718271004671 active site 718271004672 motif I; other site 718271004673 motif II; other site 718271004674 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 718271004675 putative active site pocket [active] 718271004676 4-fold oligomerization interface [polypeptide binding]; other site 718271004677 metal binding residues [ion binding]; metal-binding site 718271004678 3-fold/trimer interface [polypeptide binding]; other site 718271004679 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 718271004680 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 718271004681 putative active site [active] 718271004682 oxyanion strand; other site 718271004683 catalytic triad [active] 718271004684 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 718271004685 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 718271004686 catalytic residues [active] 718271004687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2958 718271004688 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 718271004689 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 718271004690 substrate binding site [chemical binding]; other site 718271004691 glutamase interaction surface [polypeptide binding]; other site 718271004692 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 718271004693 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 718271004694 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 718271004695 metal binding site [ion binding]; metal-binding site 718271004696 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 718271004697 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 718271004698 putative trimer interface [polypeptide binding]; other site 718271004699 putative CoA binding site [chemical binding]; other site 718271004700 antiporter inner membrane protein; Provisional; Region: PRK11670 718271004701 Domain of unknown function DUF59; Region: DUF59; pfam01883 718271004702 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 718271004703 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 718271004704 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 718271004705 substrate binding site; other site 718271004706 dimer interface; other site 718271004707 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 718271004708 homotrimer interaction site [polypeptide binding]; other site 718271004709 zinc binding site [ion binding]; other site 718271004710 CDP-binding sites; other site 718271004711 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 718271004712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718271004713 active site 718271004714 intermolecular recognition site; other site 718271004715 dimerization interface [polypeptide binding]; other site 718271004716 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046 718271004717 ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747 718271004718 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 718271004719 tetramer interfaces [polypeptide binding]; other site 718271004720 binuclear metal-binding site [ion binding]; other site 718271004721 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 718271004722 peptide chain release factor 1; Validated; Region: prfA; PRK00591 718271004723 This domain is found in peptide chain release factors; Region: PCRF; smart00937 718271004724 RF-1 domain; Region: RF-1; pfam00472 718271004725 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 718271004726 heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109 718271004727 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 718271004728 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 718271004729 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718271004730 N-terminal plug; other site 718271004731 ligand-binding site [chemical binding]; other site 718271004732 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 718271004733 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718271004734 ABC-ATPase subunit interface; other site 718271004735 dimer interface [polypeptide binding]; other site 718271004736 putative PBP binding regions; other site 718271004737 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 718271004738 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 718271004739 Walker A/P-loop; other site 718271004740 ATP binding site [chemical binding]; other site 718271004741 Q-loop/lid; other site 718271004742 ABC transporter signature motif; other site 718271004743 Walker B; other site 718271004744 D-loop; other site 718271004745 H-loop/switch region; other site 718271004746 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 718271004747 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 718271004748 putative binding site residues; other site 718271004749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718271004750 FeS/SAM binding site; other site 718271004751 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 718271004752 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 718271004753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271004754 putative substrate translocation pore; other site 718271004755 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 718271004756 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 718271004757 minor groove reading motif; other site 718271004758 helix-hairpin-helix signature motif; other site 718271004759 substrate binding pocket [chemical binding]; other site 718271004760 active site 718271004761 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 718271004762 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 718271004763 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 718271004764 catalytic motif [active] 718271004765 Zn binding site [ion binding]; other site 718271004766 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 718271004767 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 718271004768 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 718271004769 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 718271004770 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 718271004771 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 718271004772 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 718271004773 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 718271004774 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 718271004775 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 718271004776 TonB system transport protein ExbD, group 2; Region: ExbD_2; TIGR02804 718271004777 Ferric siderophore transport system, periplasmic binding protein TonB 718271004778 Protein of unknown function (DUF3135); Region: DUF3135; pfam11333 718271004779 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 718271004780 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 718271004781 Ligand Binding Site [chemical binding]; other site 718271004782 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 718271004783 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 718271004784 Tetramer interface [polypeptide binding]; other site 718271004785 active site 718271004786 FMN-binding site [chemical binding]; other site 718271004787 ribonuclease III; Reviewed; Region: rnc; PRK00102 718271004788 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 718271004789 dimerization interface [polypeptide binding]; other site 718271004790 active site 718271004791 metal binding site [ion binding]; metal-binding site 718271004792 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 718271004793 dsRNA binding site [nucleotide binding]; other site 718271004794 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 718271004795 RNA/DNA hybrid binding site [nucleotide binding]; other site 718271004796 active site 718271004797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718271004798 TPR motif; other site 718271004799 binding surface 718271004800 Tetratricopeptide repeat; Region: TPR_16; pfam13432 718271004801 Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have...; Region: ZZ; cl00295 718271004802 Zinc-binding sites [ion binding]; other site 718271004803 zinc cluster 1 [ion binding]; other site 718271004804 putative charged binding surface; other site 718271004805 putative hydrophobic binding surface; other site 718271004806 zinc cluster 2 [ion binding]; other site 718271004807 DNA primase, catalytic core; Region: dnaG; TIGR01391 718271004808 CHC2 zinc finger; Region: zf-CHC2; pfam01807 718271004809 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 718271004810 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 718271004811 active site 718271004812 metal binding site [ion binding]; metal-binding site 718271004813 interdomain interaction site; other site 718271004814 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 718271004815 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 718271004816 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718271004817 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718271004818 hypothetical protein; Provisional; Region: PRK03762 718271004819 PDZ domain; Region: PDZ_2; pfam13180 718271004820 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 718271004821 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 718271004822 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 718271004823 substrate binding pocket [chemical binding]; other site 718271004824 chain length determination region; other site 718271004825 substrate-Mg2+ binding site; other site 718271004826 catalytic residues [active] 718271004827 aspartate-rich region 1; other site 718271004828 active site lid residues [active] 718271004829 aspartate-rich region 2; other site 718271004830 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 718271004831 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 718271004832 TPP-binding site [chemical binding]; other site 718271004833 dimer interface [polypeptide binding]; other site 718271004834 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 718271004835 PYR/PP interface [polypeptide binding]; other site 718271004836 dimer interface [polypeptide binding]; other site 718271004837 TPP binding site [chemical binding]; other site 718271004838 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 718271004839 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 718271004840 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 718271004841 Permease; Region: Permease; pfam02405 718271004842 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 718271004843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718271004844 Walker A/P-loop; other site 718271004845 ATP binding site [chemical binding]; other site 718271004846 Q-loop/lid; other site 718271004847 ABC transporter signature motif; other site 718271004848 Walker B; other site 718271004849 D-loop; other site 718271004850 H-loop/switch region; other site 718271004851 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 718271004852 mce related protein; Region: MCE; pfam02470 718271004853 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 718271004854 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 718271004855 active site 718271004856 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 718271004857 NlpC/P60 family; Region: NLPC_P60; pfam00877 718271004858 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 718271004859 Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004 718271004860 Putative motility protein; Region: YjfB_motility; pfam14070 718271004861 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 718271004862 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 718271004863 Predicted membrane protein [Function unknown]; Region: COG4393 718271004864 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 718271004865 Uncharacterized conserved protein [Function unknown]; Region: COG3350 718271004866 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 718271004867 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 718271004868 FtsX-like permease family; Region: FtsX; pfam02687 718271004869 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 718271004870 FtsX-like permease family; Region: FtsX; pfam02687 718271004871 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 718271004872 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 718271004873 Walker A/P-loop; other site 718271004874 ATP binding site [chemical binding]; other site 718271004875 Q-loop/lid; other site 718271004876 ABC transporter signature motif; other site 718271004877 Walker B; other site 718271004878 D-loop; other site 718271004879 H-loop/switch region; other site 718271004880 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 718271004881 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 718271004882 catalytic residues [active] 718271004883 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 718271004884 Predicted metal-binding protein [General function prediction only]; Region: COG3019 718271004885 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 718271004886 active site 718271004887 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 718271004888 DNA binding site [nucleotide binding] 718271004889 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 718271004890 DNA binding site [nucleotide binding] 718271004891 AMIN domain; Region: AMIN; pfam11741 718271004892 enolase; Provisional; Region: eno; PRK00077 718271004893 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 718271004894 dimer interface [polypeptide binding]; other site 718271004895 metal binding site [ion binding]; metal-binding site 718271004896 substrate binding pocket [chemical binding]; other site 718271004897 recombinase A; Provisional; Region: recA; PRK09354 718271004898 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 718271004899 hexamer interface [polypeptide binding]; other site 718271004900 Walker A motif; other site 718271004901 ATP binding site [chemical binding]; other site 718271004902 Walker B motif; other site 718271004903 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 718271004904 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 718271004905 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 718271004906 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 718271004907 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 718271004908 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 718271004909 active site 718271004910 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 718271004911 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 718271004912 dimer interface [polypeptide binding]; other site 718271004913 active site 718271004914 citrylCoA binding site [chemical binding]; other site 718271004915 NADH binding [chemical binding]; other site 718271004916 cationic pore residues; other site 718271004917 oxalacetate/citrate binding site [chemical binding]; other site 718271004918 coenzyme A binding site [chemical binding]; other site 718271004919 catalytic triad [active] 718271004920 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 718271004921 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 718271004922 biotin synthase; Provisional; Region: PRK08508 718271004923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718271004924 FeS/SAM binding site; other site 718271004925 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 718271004926 DNA topoisomerase I; Validated; Region: PRK05582 718271004927 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 718271004928 active site 718271004929 interdomain interaction site; other site 718271004930 putative metal-binding site [ion binding]; other site 718271004931 nucleotide binding site [chemical binding]; other site 718271004932 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 718271004933 domain I; other site 718271004934 DNA binding groove [nucleotide binding] 718271004935 phosphate binding site [ion binding]; other site 718271004936 domain II; other site 718271004937 domain III; other site 718271004938 nucleotide binding site [chemical binding]; other site 718271004939 catalytic site [active] 718271004940 domain IV; other site 718271004941 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 718271004942 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 718271004943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718271004944 putative substrate translocation pore; other site 718271004945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718271004946 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 718271004947 SecY translocase; Region: SecY; pfam00344 718271004948 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 718271004949 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 718271004950 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 718271004951 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 718271004952 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 718271004953 5S rRNA interface [nucleotide binding]; other site 718271004954 23S rRNA interface [nucleotide binding]; other site 718271004955 L5 interface [polypeptide binding]; other site 718271004956 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 718271004957 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 718271004958 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 718271004959 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 718271004960 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 718271004961 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 718271004962 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 718271004963 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 718271004964 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 718271004965 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 718271004966 RNA binding site [nucleotide binding]; other site 718271004967 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 718271004968 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 718271004969 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 718271004970 putative translocon interaction site; other site 718271004971 23S rRNA interface [nucleotide binding]; other site 718271004972 signal recognition particle (SRP54) interaction site; other site 718271004973 L23 interface [polypeptide binding]; other site 718271004974 trigger factor interaction site; other site 718271004975 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 718271004976 23S rRNA interface [nucleotide binding]; other site 718271004977 5S rRNA interface [nucleotide binding]; other site 718271004978 putative antibiotic binding site [chemical binding]; other site 718271004979 L25 interface [polypeptide binding]; other site 718271004980 L27 interface [polypeptide binding]; other site 718271004981 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 718271004982 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 718271004983 G-X-X-G motif; other site 718271004984 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 718271004985 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 718271004986 putative translocon binding site; other site 718271004987 protein-rRNA interface [nucleotide binding]; other site 718271004988 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 718271004989 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 718271004990 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 718271004991 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 718271004992 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 718271004993 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 718271004994 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 718271004995 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 718271004996 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 718271004997 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718271004998 RNA binding surface [nucleotide binding]; other site 718271004999 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 718271005000 active site 718271005001 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 718271005002 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 718271005003 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 718271005004 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 718271005005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718271005006 S-adenosylmethionine binding site [chemical binding]; other site 718271005007 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 718271005008 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 718271005009 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718271005010 FeS/SAM binding site; other site 718271005011 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 718271005012 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 718271005013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718271005014 Coenzyme A binding pocket [chemical binding]; other site 718271005015 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 718271005016 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 718271005017 substrate binding site [chemical binding]; other site 718271005018 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 718271005019 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 718271005020 substrate binding site [chemical binding]; other site 718271005021 ligand binding site [chemical binding]; other site 718271005022 tartrate dehydrogenase; Region: TTC; TIGR02089 718271005023 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 718271005024 2-isopropylmalate synthase; Validated; Region: PRK00915 718271005025 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 718271005026 active site 718271005027 catalytic residues [active] 718271005028 metal binding site [ion binding]; metal-binding site 718271005029 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 718271005030 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 718271005031 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 718271005032 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 718271005033 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 718271005034 homoserine O-succinyltransferase; Region: metA; TIGR01001 718271005035 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 718271005036 proposed active site lysine [active] 718271005037 conserved cys residue [active] 718271005038 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 718271005039 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 718271005040 homodimer interface [polypeptide binding]; other site 718271005041 substrate-cofactor binding pocket; other site 718271005042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718271005043 catalytic residue [active] 718271005044 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 718271005045 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718271005046 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 718271005047 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718271005048 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 718271005049 active site 718271005050 putative DNA-binding cleft [nucleotide binding]; other site 718271005051 dimer interface [polypeptide binding]; other site 718271005052 Methyltransferase domain; Region: Methyltransf_26; pfam13659 718271005053 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 718271005054 DEAD-like helicases superfamily; Region: DEXDc; smart00487 718271005055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 718271005056 ATP binding site [chemical binding]; other site 718271005057 putative Mg++ binding site [ion binding]; other site 718271005058 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 718271005059 helicase superfamily c-terminal domain; Region: HELICc; smart00490 718271005060 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718271005061 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 718271005062 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 718271005063 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 718271005064 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 718271005065 G1 box; other site 718271005066 putative GEF interaction site [polypeptide binding]; other site 718271005067 GTP/Mg2+ binding site [chemical binding]; other site 718271005068 Switch I region; other site 718271005069 G2 box; other site 718271005070 G3 box; other site 718271005071 Switch II region; other site 718271005072 G4 box; other site 718271005073 G5 box; other site 718271005074 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 718271005075 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 718271005076 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 718271005077 DNA topoisomerase III; Provisional; Region: PRK07726 718271005078 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 718271005079 active site 718271005080 putative interdomain interaction site [polypeptide binding]; other site 718271005081 putative metal-binding site [ion binding]; other site 718271005082 putative nucleotide binding site [chemical binding]; other site 718271005083 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 718271005084 domain I; other site 718271005085 DNA binding groove [nucleotide binding] 718271005086 phosphate binding site [ion binding]; other site 718271005087 domain II; other site 718271005088 domain III; other site 718271005089 nucleotide binding site [chemical binding]; other site 718271005090 catalytic site [active] 718271005091 domain IV; other site 718271005092 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 718271005093 TrbM; Region: TrbM; pfam07424 718271005094 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 718271005095 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 718271005096 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 718271005097 Walker A motif; other site 718271005098 ATP binding site [chemical binding]; other site 718271005099 Walker B motif; other site 718271005100 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 718271005101 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 718271005102 Walker A motif; other site 718271005103 hexamer interface [polypeptide binding]; other site 718271005104 ATP binding site [chemical binding]; other site 718271005105 Walker B motif; other site 718271005106 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 718271005107 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 718271005108 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 718271005109 VirB7 interaction site; other site 718271005110 VirB8 protein; Region: VirB8; pfam04335 718271005111 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 718271005112 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 718271005113 Type IV secretion system proteins; Region: T4SS; pfam07996 718271005114 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 718271005115 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 718271005116 dimer interface [polypeptide binding]; other site 718271005117 ssDNA binding site [nucleotide binding]; other site 718271005118 tetramer (dimer of dimers) interface [polypeptide binding]; other site 718271005119 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 718271005120 Type IV secretory pathway, VirB3-like protein; Region: VirB3; pfam05101 718271005121 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 718271005122 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 718271005123 TrbC/VIRB2 family; Region: TrbC; pfam04956 718271005124 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 718271005125 catalytic residues [active] 718271005126 catalytic nucleophile [active] 718271005127 Presynaptic Site I dimer interface [polypeptide binding]; other site 718271005128 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 718271005129 Synaptic Flat tetramer interface [polypeptide binding]; other site 718271005130 Synaptic Site I dimer interface [polypeptide binding]; other site 718271005131 DNA binding site [nucleotide binding] 718271005132 cpp26 718271005133 YcfA-like protein; Region: YcfA; cl00752 718271005134 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 718271005135 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 718271005136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 718271005137 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 718271005138 active site 718271005139 metal binding site [ion binding]; metal-binding site 718271005140 interdomain interaction site; other site 718271005141 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 718271005142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 718271005143 Coenzyme A binding pocket [chemical binding]; other site 718271005144 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 718271005145 LabA_like proteins; Region: LabA_like; cd06167 718271005146 putative metal binding site [ion binding]; other site 718271005147 Uncharacterized conserved protein [Function unknown]; Region: COG1432