-- dump date 20140619_022138 -- class Genbank::misc_feature -- table misc_feature_note -- id note 306263000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 306263000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 306263000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263000004 Walker A motif; other site 306263000005 ATP binding site [chemical binding]; other site 306263000006 Walker B motif; other site 306263000007 arginine finger; other site 306263000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 306263000009 DnaA box-binding interface [nucleotide binding]; other site 306263000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 306263000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 306263000012 putative DNA binding surface [nucleotide binding]; other site 306263000013 dimer interface [polypeptide binding]; other site 306263000014 beta-clamp/clamp loader binding surface; other site 306263000015 beta-clamp/translesion DNA polymerase binding surface; other site 306263000016 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 306263000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263000018 Mg2+ binding site [ion binding]; other site 306263000019 G-X-G motif; other site 306263000020 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 306263000021 anchoring element; other site 306263000022 dimer interface [polypeptide binding]; other site 306263000023 ATP binding site [chemical binding]; other site 306263000024 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 306263000025 active site 306263000026 putative metal-binding site [ion binding]; other site 306263000027 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 306263000028 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 306263000029 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 306263000030 active site 306263000031 purine riboside binding site [chemical binding]; other site 306263000032 Protein of unknown function (DUF511); Region: DUF511; pfam04373 306263000033 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 306263000034 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 306263000035 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 306263000036 Moco binding site; other site 306263000037 metal coordination site [ion binding]; other site 306263000038 dimerization interface [polypeptide binding]; other site 306263000039 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 306263000040 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 306263000041 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 306263000042 PhnA protein; Region: PhnA; pfam03831 306263000043 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 306263000044 CTP synthetase; Validated; Region: pyrG; PRK05380 306263000045 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 306263000046 Catalytic site [active] 306263000047 active site 306263000048 UTP binding site [chemical binding]; other site 306263000049 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 306263000050 active site 306263000051 putative oxyanion hole; other site 306263000052 catalytic triad [active] 306263000053 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 306263000054 DHH family; Region: DHH; pfam01368 306263000055 DHHA1 domain; Region: DHHA1; pfam02272 306263000056 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 306263000057 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 306263000058 N-acetyl-D-glucosamine binding site [chemical binding]; other site 306263000059 catalytic residue [active] 306263000060 peptide chain release factor 1; Validated; Region: prfA; PRK00591 306263000061 This domain is found in peptide chain release factors; Region: PCRF; smart00937 306263000062 RF-1 domain; Region: RF-1; pfam00472 306263000063 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 306263000064 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 306263000065 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 306263000066 RNA binding surface [nucleotide binding]; other site 306263000067 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 306263000068 active site 306263000069 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 306263000070 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 306263000071 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 306263000072 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 306263000073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263000074 S-adenosylmethionine binding site [chemical binding]; other site 306263000075 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 306263000076 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 306263000077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263000078 FeS/SAM binding site; other site 306263000079 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 306263000080 FeS/SAM binding site; other site 306263000081 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 306263000082 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 306263000083 active site 306263000084 adenylosuccinate lyase; Provisional; Region: PRK08470 306263000085 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 306263000086 tetramer interface [polypeptide binding]; other site 306263000087 active site 306263000088 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 306263000089 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 306263000090 ATP cone domain; Region: ATP-cone; pfam03477 306263000091 Class I ribonucleotide reductase; Region: RNR_I; cd01679 306263000092 active site 306263000093 dimer interface [polypeptide binding]; other site 306263000094 catalytic residues [active] 306263000095 effector binding site; other site 306263000096 R2 peptide binding site; other site 306263000097 Predicted membrane protein [Function unknown]; Region: COG1297 306263000098 putative oligopeptide transporter, OPT family; Region: TIGR00733 306263000099 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 306263000100 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 306263000101 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 306263000102 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 306263000103 active site 306263000104 dimer interface [polypeptide binding]; other site 306263000105 motif 1; other site 306263000106 motif 2; other site 306263000107 motif 3; other site 306263000108 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 306263000109 anticodon binding site; other site 306263000110 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 306263000111 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 306263000112 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 306263000113 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 306263000114 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 306263000115 Predicted transcriptional regulator [Transcription]; Region: COG2378 306263000116 HTH domain; Region: HTH_11; pfam08279 306263000117 WYL domain; Region: WYL; pfam13280 306263000118 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 306263000119 metal ion-dependent adhesion site (MIDAS); other site 306263000120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263000121 Walker A motif; other site 306263000122 ATP binding site [chemical binding]; other site 306263000123 Walker B motif; other site 306263000124 arginine finger; other site 306263000125 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 306263000126 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 306263000127 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 306263000128 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 306263000129 23S rRNA binding site [nucleotide binding]; other site 306263000130 L21 binding site [polypeptide binding]; other site 306263000131 L13 binding site [polypeptide binding]; other site 306263000132 DNA ligase; Provisional; Region: PRK09125 306263000133 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 306263000134 DNA binding site [nucleotide binding] 306263000135 active site 306263000136 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 306263000137 DNA binding site [nucleotide binding] 306263000138 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 306263000139 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 306263000140 dimer interface [polypeptide binding]; other site 306263000141 putative PBP binding regions; other site 306263000142 ABC-ATPase subunit interface; other site 306263000143 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 306263000144 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 306263000145 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 306263000146 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 306263000147 intersubunit interface [polypeptide binding]; other site 306263000148 Methyltransferase domain; Region: Methyltransf_23; pfam13489 306263000149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263000150 S-adenosylmethionine binding site [chemical binding]; other site 306263000151 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 306263000152 active site 306263000153 substrate binding pocket [chemical binding]; other site 306263000154 dimer interface [polypeptide binding]; other site 306263000155 Helix-turn-helix domain; Region: HTH_36; pfam13730 306263000156 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 306263000157 putative metal dependent hydrolase; Provisional; Region: PRK11598 306263000158 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 306263000159 Sulfatase; Region: Sulfatase; pfam00884 306263000160 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 306263000161 putative catalytic site [active] 306263000162 putative metal binding site [ion binding]; other site 306263000163 putative phosphate binding site [ion binding]; other site 306263000164 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 306263000165 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 306263000166 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 306263000167 ATP cone domain; Region: ATP-cone; pfam03477 306263000168 Class III ribonucleotide reductase; Region: RNR_III; cd01675 306263000169 effector binding site; other site 306263000170 active site 306263000171 Zn binding site [ion binding]; other site 306263000172 glycine loop; other site 306263000173 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 306263000174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263000175 FeS/SAM binding site; other site 306263000176 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 306263000177 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 306263000178 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 306263000179 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 306263000180 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 306263000181 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 306263000182 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 306263000183 dimerization interface [polypeptide binding]; other site 306263000184 putative ATP binding site [chemical binding]; other site 306263000185 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 306263000186 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 306263000187 CoA-binding site [chemical binding]; other site 306263000188 ATP-binding [chemical binding]; other site 306263000189 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 306263000190 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 306263000191 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 306263000192 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 306263000193 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 306263000194 AAA domain; Region: AAA_14; pfam13173 306263000195 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 306263000196 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 306263000197 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 306263000198 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 306263000199 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 306263000200 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 306263000201 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 306263000202 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 306263000203 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 306263000204 putative translocon binding site; other site 306263000205 protein-rRNA interface [nucleotide binding]; other site 306263000206 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 306263000207 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 306263000208 G-X-X-G motif; other site 306263000209 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 306263000210 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 306263000211 23S rRNA interface [nucleotide binding]; other site 306263000212 5S rRNA interface [nucleotide binding]; other site 306263000213 putative antibiotic binding site [chemical binding]; other site 306263000214 L25 interface [polypeptide binding]; other site 306263000215 L27 interface [polypeptide binding]; other site 306263000216 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 306263000217 putative translocon interaction site; other site 306263000218 23S rRNA interface [nucleotide binding]; other site 306263000219 signal recognition particle (SRP54) interaction site; other site 306263000220 L23 interface [polypeptide binding]; other site 306263000221 trigger factor interaction site; other site 306263000222 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 306263000223 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 306263000224 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 306263000225 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 306263000226 RNA binding site [nucleotide binding]; other site 306263000227 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 306263000228 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 306263000229 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 306263000230 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 306263000231 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 306263000232 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 306263000233 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 306263000234 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 306263000235 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 306263000236 5S rRNA interface [nucleotide binding]; other site 306263000237 23S rRNA interface [nucleotide binding]; other site 306263000238 L5 interface [polypeptide binding]; other site 306263000239 ribosomal protein S5; Validated; Region: rps5; CHL00138 306263000240 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 306263000241 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 306263000242 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 306263000243 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 306263000244 SecY translocase; Region: SecY; pfam00344 306263000245 glutamate racemase; Provisional; Region: PRK00865 306263000246 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 306263000247 active site 306263000248 homotetramer interface [polypeptide binding]; other site 306263000249 homodimer interface [polypeptide binding]; other site 306263000250 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 306263000251 non-heme iron binding site [ion binding]; other site 306263000252 dimer interface [polypeptide binding]; other site 306263000253 Rubrerythrin [Energy production and conversion]; Region: COG1592 306263000254 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 306263000255 binuclear metal center [ion binding]; other site 306263000256 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 306263000257 iron binding site [ion binding]; other site 306263000258 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 306263000259 putative active site [active] 306263000260 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 306263000261 RNA/DNA hybrid binding site [nucleotide binding]; other site 306263000262 active site 306263000263 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 306263000264 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 306263000265 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 306263000266 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 306263000267 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 306263000268 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 306263000269 active site 306263000270 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 306263000271 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263000272 dimer interface [polypeptide binding]; other site 306263000273 putative CheW interface [polypeptide binding]; other site 306263000274 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 306263000275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263000276 metabolite-proton symporter; Region: 2A0106; TIGR00883 306263000277 putative substrate translocation pore; other site 306263000278 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 306263000279 rRNA binding site [nucleotide binding]; other site 306263000280 predicted 30S ribosome binding site; other site 306263000281 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 306263000282 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 306263000283 30S ribosomal protein S13; Region: bact_S13; TIGR03631 306263000284 30S ribosomal protein S11; Validated; Region: PRK05309 306263000285 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 306263000286 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 306263000287 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 306263000288 RNA binding surface [nucleotide binding]; other site 306263000289 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 306263000290 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 306263000291 alphaNTD homodimer interface [polypeptide binding]; other site 306263000292 alphaNTD - beta interaction site [polypeptide binding]; other site 306263000293 alphaNTD - beta' interaction site [polypeptide binding]; other site 306263000294 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 306263000295 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 306263000296 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 306263000297 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 306263000298 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 306263000299 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 306263000300 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 306263000301 NAD binding site [chemical binding]; other site 306263000302 dimerization interface [polypeptide binding]; other site 306263000303 product binding site; other site 306263000304 substrate binding site [chemical binding]; other site 306263000305 zinc binding site [ion binding]; other site 306263000306 catalytic residues [active] 306263000307 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 306263000308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263000309 active site 306263000310 motif I; other site 306263000311 motif II; other site 306263000312 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 306263000313 putative active site pocket [active] 306263000314 4-fold oligomerization interface [polypeptide binding]; other site 306263000315 metal binding residues [ion binding]; metal-binding site 306263000316 3-fold/trimer interface [polypeptide binding]; other site 306263000317 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 306263000318 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 306263000319 putative active site [active] 306263000320 oxyanion strand; other site 306263000321 catalytic triad [active] 306263000322 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 306263000323 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 306263000324 catalytic residues [active] 306263000325 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 306263000326 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 306263000327 substrate binding site [chemical binding]; other site 306263000328 glutamase interaction surface [polypeptide binding]; other site 306263000329 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 306263000330 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 306263000331 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 306263000332 metal binding site [ion binding]; metal-binding site 306263000333 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 306263000334 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263000335 dimer interface [polypeptide binding]; other site 306263000336 putative CheW interface [polypeptide binding]; other site 306263000337 LabA_like proteins; Region: LabA_like; cd06167 306263000338 putative metal binding site [ion binding]; other site 306263000339 Uncharacterized conserved protein [Function unknown]; Region: COG1432 306263000340 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 306263000341 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 306263000342 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 306263000343 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 306263000344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 306263000345 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 306263000346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263000347 putative substrate translocation pore; other site 306263000348 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 306263000349 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 306263000350 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306263000351 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 306263000352 hypothetical protein; Provisional; Region: PRK03762 306263000353 PDZ domain; Region: PDZ_2; pfam13180 306263000354 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 306263000355 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 306263000356 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 306263000357 substrate binding pocket [chemical binding]; other site 306263000358 chain length determination region; other site 306263000359 substrate-Mg2+ binding site; other site 306263000360 catalytic residues [active] 306263000361 aspartate-rich region 1; other site 306263000362 active site lid residues [active] 306263000363 aspartate-rich region 2; other site 306263000364 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 306263000365 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 306263000366 TPP-binding site [chemical binding]; other site 306263000367 dimer interface [polypeptide binding]; other site 306263000368 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 306263000369 PYR/PP interface [polypeptide binding]; other site 306263000370 dimer interface [polypeptide binding]; other site 306263000371 TPP binding site [chemical binding]; other site 306263000372 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 306263000373 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 306263000374 anti sigma factor interaction site; other site 306263000375 regulatory phosphorylation site [posttranslational modification]; other site 306263000376 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 306263000377 Permease; Region: Permease; pfam02405 306263000378 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 306263000379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306263000380 Walker A/P-loop; other site 306263000381 ATP binding site [chemical binding]; other site 306263000382 Q-loop/lid; other site 306263000383 ABC transporter signature motif; other site 306263000384 Walker B; other site 306263000385 D-loop; other site 306263000386 H-loop/switch region; other site 306263000387 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 306263000388 mce related protein; Region: MCE; pfam02470 306263000389 Protein of unknown function (DUF330); Region: DUF330; cl01135 306263000390 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 306263000391 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 306263000392 E-class dimer interface [polypeptide binding]; other site 306263000393 P-class dimer interface [polypeptide binding]; other site 306263000394 active site 306263000395 Cu2+ binding site [ion binding]; other site 306263000396 Zn2+ binding site [ion binding]; other site 306263000397 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 306263000398 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 306263000399 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 306263000400 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 306263000401 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 306263000402 ligand binding site [chemical binding]; other site 306263000403 active site 306263000404 UGI interface [polypeptide binding]; other site 306263000405 catalytic site [active] 306263000406 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 306263000407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 306263000408 dimer interface [polypeptide binding]; other site 306263000409 phosphorylation site [posttranslational modification] 306263000410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263000411 ATP binding site [chemical binding]; other site 306263000412 Mg2+ binding site [ion binding]; other site 306263000413 G-X-G motif; other site 306263000414 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306263000415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263000416 active site 306263000417 phosphorylation site [posttranslational modification] 306263000418 intermolecular recognition site; other site 306263000419 dimerization interface [polypeptide binding]; other site 306263000420 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 306263000421 DNA binding site [nucleotide binding] 306263000422 Protein of unknown function (DUF1104); Region: DUF1104; pfam06518 306263000423 Protein of unknown function (DUF541); Region: SIMPL; cl01077 306263000424 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 306263000425 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 306263000426 minor groove reading motif; other site 306263000427 helix-hairpin-helix signature motif; other site 306263000428 substrate binding pocket [chemical binding]; other site 306263000429 active site 306263000430 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263000431 FeS/SAM binding site; other site 306263000432 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 306263000433 SprA-related family; Region: SprA-related; pfam12118 306263000434 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 306263000435 TrkA-N domain; Region: TrkA_N; pfam02254 306263000436 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 306263000437 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 306263000438 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 306263000439 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 306263000440 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 306263000441 Aspartase; Region: Aspartase; cd01357 306263000442 active sites [active] 306263000443 tetramer interface [polypeptide binding]; other site 306263000444 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 306263000445 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263000446 dimer interface [polypeptide binding]; other site 306263000447 putative CheW interface [polypeptide binding]; other site 306263000448 Protein of unknown function (DUF493); Region: DUF493; cl01102 306263000449 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 306263000450 trimer interface [polypeptide binding]; other site 306263000451 dimer interface [polypeptide binding]; other site 306263000452 putative active site [active] 306263000453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263000454 metabolite-proton symporter; Region: 2A0106; TIGR00883 306263000455 putative substrate translocation pore; other site 306263000456 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 306263000457 apolar tunnel; other site 306263000458 heme binding site [chemical binding]; other site 306263000459 dimerization interface [polypeptide binding]; other site 306263000460 AMIN domain; Region: AMIN; pfam11741 306263000461 enolase; Provisional; Region: eno; PRK00077 306263000462 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 306263000463 dimer interface [polypeptide binding]; other site 306263000464 metal binding site [ion binding]; metal-binding site 306263000465 substrate binding pocket [chemical binding]; other site 306263000466 recombinase A; Provisional; Region: recA; PRK09354 306263000467 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 306263000468 hexamer interface [polypeptide binding]; other site 306263000469 Walker A motif; other site 306263000470 ATP binding site [chemical binding]; other site 306263000471 Walker B motif; other site 306263000472 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 306263000473 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 306263000474 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 306263000475 FAD binding domain; Region: FAD_binding_4; pfam01565 306263000476 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 306263000477 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 306263000478 active site 306263000479 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 306263000480 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 306263000481 biotin synthase; Provisional; Region: PRK08508 306263000482 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263000483 FeS/SAM binding site; other site 306263000484 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 306263000485 DNA topoisomerase I; Validated; Region: PRK05582 306263000486 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 306263000487 active site 306263000488 interdomain interaction site; other site 306263000489 putative metal-binding site [ion binding]; other site 306263000490 nucleotide binding site [chemical binding]; other site 306263000491 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 306263000492 domain I; other site 306263000493 DNA binding groove [nucleotide binding] 306263000494 phosphate binding site [ion binding]; other site 306263000495 domain II; other site 306263000496 domain III; other site 306263000497 nucleotide binding site [chemical binding]; other site 306263000498 catalytic site [active] 306263000499 domain IV; other site 306263000500 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 306263000501 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 306263000502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 306263000503 flagellin; Provisional; Region: PRK13589 306263000504 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 306263000505 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 306263000506 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 306263000507 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 306263000508 flagellin; Reviewed; Region: PRK08411 306263000509 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 306263000510 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 306263000511 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 306263000512 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 306263000513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 306263000514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 306263000515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 306263000516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 306263000517 pseudaminic acid synthase; Region: PseI; TIGR03586 306263000518 NeuB family; Region: NeuB; pfam03102 306263000519 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 306263000520 NeuB binding interface [polypeptide binding]; other site 306263000521 putative substrate binding site [chemical binding]; other site 306263000522 flagellar motor switch protein; Validated; Region: PRK08433 306263000523 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 306263000524 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 306263000525 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 306263000526 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306263000527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263000528 active site 306263000529 phosphorylation site [posttranslational modification] 306263000530 intermolecular recognition site; other site 306263000531 dimerization interface [polypeptide binding]; other site 306263000532 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 306263000533 DNA binding site [nucleotide binding] 306263000534 Dihydroneopterin aldolase; Region: FolB; pfam02152 306263000535 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 306263000536 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 306263000537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 306263000538 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 306263000539 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 306263000540 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 306263000541 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 306263000542 GTPase CgtA; Reviewed; Region: obgE; PRK12299 306263000543 GTP1/OBG; Region: GTP1_OBG; pfam01018 306263000544 Obg GTPase; Region: Obg; cd01898 306263000545 G1 box; other site 306263000546 GTP/Mg2+ binding site [chemical binding]; other site 306263000547 Switch I region; other site 306263000548 G2 box; other site 306263000549 G3 box; other site 306263000550 Switch II region; other site 306263000551 G4 box; other site 306263000552 G5 box; other site 306263000553 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 306263000554 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 306263000555 putative active site [active] 306263000556 substrate binding site [chemical binding]; other site 306263000557 putative cosubstrate binding site; other site 306263000558 catalytic site [active] 306263000559 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 306263000560 substrate binding site [chemical binding]; other site 306263000561 biotin--protein ligase; Provisional; Region: PRK08477 306263000562 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 306263000563 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 306263000564 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 306263000565 P-loop; other site 306263000566 Magnesium ion binding site [ion binding]; other site 306263000567 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 306263000568 Magnesium ion binding site [ion binding]; other site 306263000569 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 306263000570 ParB-like nuclease domain; Region: ParBc; pfam02195 306263000571 F0F1 ATP synthase subunit B'; Validated; Region: PRK08476 306263000572 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 306263000573 F0F1 ATP synthase subunit B; Validated; Region: PRK08475 306263000574 F0F1 ATP synthase subunit delta; Validated; Region: PRK08474 306263000575 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 306263000576 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 306263000577 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 306263000578 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 306263000579 beta subunit interaction interface [polypeptide binding]; other site 306263000580 Walker A motif; other site 306263000581 ATP binding site [chemical binding]; other site 306263000582 Walker B motif; other site 306263000583 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 306263000584 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 306263000585 core domain interface [polypeptide binding]; other site 306263000586 delta subunit interface [polypeptide binding]; other site 306263000587 epsilon subunit interface [polypeptide binding]; other site 306263000588 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 306263000589 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 306263000590 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 306263000591 alpha subunit interaction interface [polypeptide binding]; other site 306263000592 Walker A motif; other site 306263000593 ATP binding site [chemical binding]; other site 306263000594 Walker B motif; other site 306263000595 inhibitor binding site; inhibition site 306263000596 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 306263000597 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 306263000598 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 306263000599 gamma subunit interface [polypeptide binding]; other site 306263000600 epsilon subunit interface [polypeptide binding]; other site 306263000601 LBP interface [polypeptide binding]; other site 306263000602 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 306263000603 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 306263000604 TolR protein; Region: tolR; TIGR02801 306263000605 TonB C terminal; Region: TonB_2; pfam13103 306263000606 translocation protein TolB; Provisional; Region: tolB; PRK04043 306263000607 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 306263000608 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 306263000609 ligand binding site [chemical binding]; other site 306263000610 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 306263000611 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 306263000612 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 306263000613 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 306263000614 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 306263000615 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 306263000616 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 306263000617 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 306263000618 Ligand Binding Site [chemical binding]; other site 306263000619 Isochorismatase family; Region: Isochorismatase; pfam00857 306263000620 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 306263000621 catalytic triad [active] 306263000622 conserved cis-peptide bond; other site 306263000623 putative recombination protein RecO; Provisional; Region: PRK13908 306263000624 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 306263000625 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 306263000626 FMN binding site [chemical binding]; other site 306263000627 active site 306263000628 catalytic residues [active] 306263000629 substrate binding site [chemical binding]; other site 306263000630 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 306263000631 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 306263000632 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 306263000633 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 306263000634 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 306263000635 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 306263000636 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 306263000637 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 306263000638 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 306263000639 Surface antigen; Region: Bac_surface_Ag; pfam01103 306263000640 prephenate dehydrogenase; Validated; Region: PRK08507 306263000641 Prephenate dehydrogenase; Region: PDH; pfam02153 306263000642 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 306263000643 Peptidase family M23; Region: Peptidase_M23; pfam01551 306263000644 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 306263000645 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 306263000646 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 306263000647 homoserine kinase; Provisional; Region: PRK01212 306263000648 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 306263000649 Protein of unknown function (DUF448); Region: DUF448; pfam04296 306263000650 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 306263000651 translation initiation factor IF-2; Region: IF-2; TIGR00487 306263000652 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 306263000653 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 306263000654 G1 box; other site 306263000655 putative GEF interaction site [polypeptide binding]; other site 306263000656 GTP/Mg2+ binding site [chemical binding]; other site 306263000657 Switch I region; other site 306263000658 G2 box; other site 306263000659 G3 box; other site 306263000660 Switch II region; other site 306263000661 G4 box; other site 306263000662 G5 box; other site 306263000663 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 306263000664 Translation-initiation factor 2; Region: IF-2; pfam11987 306263000665 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 306263000666 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 306263000667 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 306263000668 Sm and related proteins; Region: Sm_like; cl00259 306263000669 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 306263000670 putative oligomer interface [polypeptide binding]; other site 306263000671 putative RNA binding site [nucleotide binding]; other site 306263000672 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 306263000673 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 306263000674 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 306263000675 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 306263000676 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 306263000677 catalytic motif [active] 306263000678 Zn binding site [ion binding]; other site 306263000679 RibD C-terminal domain; Region: RibD_C; cl17279 306263000680 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 306263000681 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 306263000682 tandem repeat interface [polypeptide binding]; other site 306263000683 oligomer interface [polypeptide binding]; other site 306263000684 active site residues [active] 306263000685 chlorohydrolase; Provisional; Region: PRK08418 306263000686 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 306263000687 active site 306263000688 Dehydroquinase class II; Region: DHquinase_II; pfam01220 306263000689 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 306263000690 trimer interface [polypeptide binding]; other site 306263000691 active site 306263000692 dimer interface [polypeptide binding]; other site 306263000693 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 306263000694 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 306263000695 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 306263000696 active site 306263000697 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 306263000698 catalytic center binding site [active] 306263000699 ATP binding site [chemical binding]; other site 306263000700 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 306263000701 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 306263000702 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 306263000703 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 306263000704 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 306263000705 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 306263000706 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 306263000707 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 306263000708 DNA binding residues [nucleotide binding] 306263000709 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 306263000710 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 306263000711 flagellar motor switch protein FliY; Validated; Region: PRK08432 306263000712 flagellar motor switch protein FliN; Region: fliN; TIGR02480 306263000713 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 306263000714 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 306263000715 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 306263000716 Ligand Binding Site [chemical binding]; other site 306263000717 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 306263000718 tetramer interfaces [polypeptide binding]; other site 306263000719 binuclear metal-binding site [ion binding]; other site 306263000720 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046 306263000721 ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747 306263000722 Response regulator receiver domain; Region: Response_reg; pfam00072 306263000723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263000724 active site 306263000725 phosphorylation site [posttranslational modification] 306263000726 intermolecular recognition site; other site 306263000727 dimerization interface [polypeptide binding]; other site 306263000728 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 306263000729 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 306263000730 substrate binding site; other site 306263000731 dimer interface; other site 306263000732 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 306263000733 homotrimer interaction site [polypeptide binding]; other site 306263000734 zinc binding site [ion binding]; other site 306263000735 CDP-binding sites; other site 306263000736 antiporter inner membrane protein; Provisional; Region: PRK11670 306263000737 Domain of unknown function DUF59; Region: DUF59; pfam01883 306263000738 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 306263000739 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 306263000740 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 306263000741 putative trimer interface [polypeptide binding]; other site 306263000742 putative CoA binding site [chemical binding]; other site 306263000743 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 306263000744 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 306263000745 dimerization interface [polypeptide binding]; other site 306263000746 DPS ferroxidase diiron center [ion binding]; other site 306263000747 ion pore; other site 306263000748 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 306263000749 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 306263000750 active site 306263000751 dimer interface [polypeptide binding]; other site 306263000752 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 306263000753 dimer interface [polypeptide binding]; other site 306263000754 active site 306263000755 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 306263000756 active site 306263000757 tetramer interface; other site 306263000758 Uncharacterized conserved protein [Function unknown]; Region: COG1739 306263000759 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 306263000760 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 306263000761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306263000762 Walker A/P-loop; other site 306263000763 ATP binding site [chemical binding]; other site 306263000764 Q-loop/lid; other site 306263000765 ABC transporter signature motif; other site 306263000766 Walker B; other site 306263000767 D-loop; other site 306263000768 H-loop/switch region; other site 306263000769 ABC transporter; Region: ABC_tran_2; pfam12848 306263000770 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 306263000771 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 306263000772 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 306263000773 active site 306263000774 substrate binding site [chemical binding]; other site 306263000775 metal binding site [ion binding]; metal-binding site 306263000776 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 306263000777 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 306263000778 Ligand Binding Site [chemical binding]; other site 306263000779 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 306263000780 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 306263000781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263000782 FeS/SAM binding site; other site 306263000783 peptide chain release factor 2; Validated; Region: prfB; PRK00578 306263000784 PCRF domain; Region: PCRF; pfam03462 306263000785 RF-1 domain; Region: RF-1; pfam00472 306263000786 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 306263000787 Ligand Binding Site [chemical binding]; other site 306263000788 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 306263000789 Ligand Binding Site [chemical binding]; other site 306263000790 Ion channel; Region: Ion_trans_2; pfam07885 306263000791 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 306263000792 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 306263000793 Predicted membrane protein [Function unknown]; Region: COG2855 306263000794 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 306263000795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 306263000796 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 306263000797 dimerization interface [polypeptide binding]; other site 306263000798 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 306263000799 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306263000800 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 306263000801 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 306263000802 Mg++ binding site [ion binding]; other site 306263000803 putative catalytic motif [active] 306263000804 putative substrate binding site [chemical binding]; other site 306263000805 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 306263000806 phosphoglyceromutase; Provisional; Region: PRK05434 306263000807 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 306263000808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263000809 NAD(P) binding site [chemical binding]; other site 306263000810 active site 306263000811 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 306263000812 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK08455 306263000813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 306263000814 YheO-like PAS domain; Region: PAS_6; pfam08348 306263000815 HTH domain; Region: HTH_22; pfam13309 306263000816 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 306263000817 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 306263000818 tetramer interface [polypeptide binding]; other site 306263000819 heme binding pocket [chemical binding]; other site 306263000820 NADPH binding site [chemical binding]; other site 306263000821 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 306263000822 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 306263000823 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 306263000824 argininosuccinate lyase; Provisional; Region: PRK00855 306263000825 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 306263000826 active sites [active] 306263000827 tetramer interface [polypeptide binding]; other site 306263000828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 306263000829 YheO-like PAS domain; Region: PAS_6; pfam08348 306263000830 HTH domain; Region: HTH_22; pfam13309 306263000831 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 306263000832 homotrimer interaction site [polypeptide binding]; other site 306263000833 putative active site [active] 306263000834 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 306263000835 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 306263000836 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 306263000837 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306263000838 catalytic residue [active] 306263000839 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 306263000840 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 306263000841 tetramer interface [polypeptide binding]; other site 306263000842 active site 306263000843 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 306263000844 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 306263000845 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 306263000846 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 306263000847 G1 box; other site 306263000848 GTP/Mg2+ binding site [chemical binding]; other site 306263000849 Switch I region; other site 306263000850 G2 box; other site 306263000851 G3 box; other site 306263000852 Switch II region; other site 306263000853 G4 box; other site 306263000854 G5 box; other site 306263000855 Nucleoside recognition; Region: Gate; pfam07670 306263000856 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 306263000857 Nucleoside recognition; Region: Gate; pfam07670 306263000858 Putative transcription activator [Transcription]; Region: TenA; COG0819 306263000859 acyl carrier protein; Provisional; Region: acpP; PRK00982 306263000860 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 306263000861 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 306263000862 dimer interface [polypeptide binding]; other site 306263000863 active site 306263000864 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 306263000865 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 306263000866 Cla_0288; potential protein location (conserved hypothetical protein (DUF455 domain protein) [Campylobacter lari RM2100]) that overlaps RNA (tRNA-F) 306263000867 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 306263000868 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 306263000869 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 306263000870 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 306263000871 Walker A/P-loop; other site 306263000872 ATP binding site [chemical binding]; other site 306263000873 Q-loop/lid; other site 306263000874 ABC transporter signature motif; other site 306263000875 Walker B; other site 306263000876 D-loop; other site 306263000877 H-loop/switch region; other site 306263000878 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 306263000879 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 306263000880 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 306263000881 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 306263000882 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 306263000883 putative active site [active] 306263000884 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 306263000885 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306263000886 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 306263000887 active site 306263000888 nucleotide binding site [chemical binding]; other site 306263000889 HIGH motif; other site 306263000890 KMSKS motif; other site 306263000891 LicD family; Region: LicD; pfam04991 306263000892 Tetratricopeptide repeat; Region: TPR_16; pfam13432 306263000893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263000894 binding surface 306263000895 TPR motif; other site 306263000896 TPR repeat; Region: TPR_11; pfam13414 306263000897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263000898 binding surface 306263000899 TPR motif; other site 306263000900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263000901 binding surface 306263000902 Tetratricopeptide repeat; Region: TPR_12; pfam13424 306263000903 TPR motif; other site 306263000904 Tetratricopeptide repeat; Region: TPR_16; pfam13432 306263000905 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 306263000906 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 306263000907 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 306263000908 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 306263000909 putative ADP-binding pocket [chemical binding]; other site 306263000910 Protein of unknown function (DUF2972); Region: DUF2972; pfam11186 306263000911 capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689 306263000912 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 306263000913 active site 306263000914 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 306263000915 active site 306263000916 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 306263000917 active site 306263000918 catalytic site [active] 306263000919 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 306263000920 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263000921 motif II; other site 306263000922 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 306263000923 Ligand binding site; other site 306263000924 SnoaL-like domain; Region: SnoaL_2; pfam12680 306263000925 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 306263000926 Ligand binding site; other site 306263000927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263000928 S-adenosylmethionine binding site [chemical binding]; other site 306263000929 Methyltransferase domain; Region: Methyltransf_31; pfam13847 306263000930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263000931 S-adenosylmethionine binding site [chemical binding]; other site 306263000932 hypothetical protein; Provisional; Region: PRK05849 306263000933 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 306263000934 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 306263000935 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 306263000936 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 306263000937 catalytic triad [active] 306263000938 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 306263000939 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 306263000940 active site 306263000941 metal-binding site 306263000942 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 306263000943 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 306263000944 ligand-binding site [chemical binding]; other site 306263000945 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 306263000946 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 306263000947 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 306263000948 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 306263000949 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 306263000950 Cytochrome P450; Region: p450; cl12078 306263000951 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 306263000952 NusA N-terminal domain; Region: NusA_N; pfam08529 306263000953 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 306263000954 RNA binding site [nucleotide binding]; other site 306263000955 homodimer interface [polypeptide binding]; other site 306263000956 NusA-like KH domain; Region: KH_5; pfam13184 306263000957 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 306263000958 G-X-X-G motif; other site 306263000959 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 306263000960 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 306263000961 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263000962 FeS/SAM binding site; other site 306263000963 TRAM domain; Region: TRAM; pfam01938 306263000964 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 306263000965 putative acyl-acceptor binding pocket; other site 306263000966 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 306263000967 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553 306263000968 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 306263000969 Iron-sulfur protein interface; other site 306263000970 proximal heme binding site [chemical binding]; other site 306263000971 distal heme binding site [chemical binding]; other site 306263000972 dimer interface [polypeptide binding]; other site 306263000973 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 306263000974 L-aspartate oxidase; Provisional; Region: PRK06175 306263000975 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 306263000976 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 306263000977 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 306263000978 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 306263000979 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 306263000980 Dynamin family; Region: Dynamin_N; pfam00350 306263000981 G1 box; other site 306263000982 GTP/Mg2+ binding site [chemical binding]; other site 306263000983 G2 box; other site 306263000984 Switch I region; other site 306263000985 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 306263000986 G3 box; other site 306263000987 Switch II region; other site 306263000988 GTP/Mg2+ binding site [chemical binding]; other site 306263000989 G4 box; other site 306263000990 G5 box; other site 306263000991 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 306263000992 Dynamin family; Region: Dynamin_N; pfam00350 306263000993 G1 box; other site 306263000994 GTP/Mg2+ binding site [chemical binding]; other site 306263000995 G2 box; other site 306263000996 Switch I region; other site 306263000997 G3 box; other site 306263000998 Switch II region; other site 306263000999 G4 box; other site 306263001000 G5 box; other site 306263001001 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 306263001002 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 306263001003 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 306263001004 Predicted transcriptional regulators [Transcription]; Region: COG1733 306263001005 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 306263001006 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 306263001007 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 306263001008 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 306263001009 putative NAD(P) binding site [chemical binding]; other site 306263001010 putative substrate binding site [chemical binding]; other site 306263001011 catalytic Zn binding site [ion binding]; other site 306263001012 structural Zn binding site [ion binding]; other site 306263001013 dimer interface [polypeptide binding]; other site 306263001014 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 306263001015 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 306263001016 DEAD-like helicases superfamily; Region: DEXDc; smart00487 306263001017 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 306263001018 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 306263001019 putative Mg++ binding site [ion binding]; other site 306263001020 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 306263001021 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 306263001022 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 306263001023 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 306263001024 Virulence protein [General function prediction only]; Region: COG3943 306263001025 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 306263001026 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 306263001027 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 306263001028 dimer interface [polypeptide binding]; other site 306263001029 putative functional site; other site 306263001030 putative MPT binding site; other site 306263001031 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 306263001032 MoaE homodimer interface [polypeptide binding]; other site 306263001033 MoaD interaction [polypeptide binding]; other site 306263001034 active site residues [active] 306263001035 ThiS family; Region: ThiS; pfam02597 306263001036 charged pocket; other site 306263001037 hydrophobic patch; other site 306263001038 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 306263001039 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 306263001040 Multicopper oxidase; Region: Cu-oxidase; pfam00394 306263001041 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 306263001042 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 306263001043 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 306263001044 dimer interface [polypeptide binding]; other site 306263001045 active site 306263001046 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306263001047 catalytic residues [active] 306263001048 substrate binding site [chemical binding]; other site 306263001049 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 306263001050 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 306263001051 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 306263001052 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 306263001053 [4Fe-4S] binding site [ion binding]; other site 306263001054 molybdopterin cofactor binding site; other site 306263001055 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 306263001056 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 306263001057 molybdopterin cofactor binding site; other site 306263001058 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 306263001059 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 306263001060 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 306263001061 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 306263001062 CPxP motif; other site 306263001063 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 306263001064 dimerization interface [polypeptide binding]; other site 306263001065 putative ATP binding site [chemical binding]; other site 306263001066 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 306263001067 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 306263001068 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 306263001069 NAD(P) binding site [chemical binding]; other site 306263001070 catalytic residues [active] 306263001071 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 306263001072 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 306263001073 Na binding site [ion binding]; other site 306263001074 hypothetical protein; Provisional; Region: PRK11018 306263001075 CPxP motif; other site 306263001076 putative inner membrane protein; Provisional; Region: PRK11099 306263001077 Sulphur transport; Region: Sulf_transp; pfam04143 306263001078 Sulphur transport; Region: Sulf_transp; pfam04143 306263001079 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 306263001080 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 306263001081 GDP-binding site [chemical binding]; other site 306263001082 ACT binding site; other site 306263001083 IMP binding site; other site 306263001084 Flagellar FliJ protein; Region: FliJ; pfam02050 306263001085 Uncharacterized conserved protein [Function unknown]; Region: COG3334 306263001086 Protein of unknown function (DUF507); Region: DUF507; pfam04368 306263001087 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 306263001088 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 306263001089 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 306263001090 catalytic site [active] 306263001091 subunit interface [polypeptide binding]; other site 306263001092 Uncharacterized conserved protein [Function unknown]; Region: COG2836 306263001093 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 306263001094 Low-spin heme binding site [chemical binding]; other site 306263001095 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 306263001096 D-pathway; other site 306263001097 Putative water exit pathway; other site 306263001098 Binuclear center (active site) [active] 306263001099 K-pathway; other site 306263001100 Putative proton exit pathway; other site 306263001101 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 306263001102 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 306263001103 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 306263001104 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 306263001105 Cytochrome c; Region: Cytochrom_C; pfam00034 306263001106 Cytochrome c; Region: Cytochrom_C; pfam00034 306263001107 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 306263001108 FixH; Region: FixH; pfam05751 306263001109 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 306263001110 Part of AAA domain; Region: AAA_19; pfam13245 306263001111 putative recombination protein RecB; Provisional; Region: PRK13909 306263001112 Family description; Region: UvrD_C_2; pfam13538 306263001113 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 306263001114 Cache domain; Region: Cache_1; pfam02743 306263001115 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 306263001116 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263001117 dimer interface [polypeptide binding]; other site 306263001118 putative CheW interface [polypeptide binding]; other site 306263001119 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 306263001120 23S rRNA interface [nucleotide binding]; other site 306263001121 L3 interface [polypeptide binding]; other site 306263001122 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 306263001123 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 306263001124 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 306263001125 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 306263001126 ligand binding site [chemical binding]; other site 306263001127 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 306263001128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263001129 active site 306263001130 motif I; other site 306263001131 motif II; other site 306263001132 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 306263001133 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 306263001134 dimer interface [polypeptide binding]; other site 306263001135 PYR/PP interface [polypeptide binding]; other site 306263001136 TPP binding site [chemical binding]; other site 306263001137 substrate binding site [chemical binding]; other site 306263001138 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 306263001139 Domain of unknown function; Region: EKR; smart00890 306263001140 4Fe-4S binding domain; Region: Fer4_6; pfam12837 306263001141 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 306263001142 TPP-binding site [chemical binding]; other site 306263001143 dimer interface [polypeptide binding]; other site 306263001144 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 306263001145 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 306263001146 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 306263001147 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 306263001148 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 306263001149 Walker A motif; other site 306263001150 ATP binding site [chemical binding]; other site 306263001151 Walker B motif; other site 306263001152 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 306263001153 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 306263001154 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 306263001155 hypothetical protein; Provisional; Region: PRK10621 306263001156 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 306263001157 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 306263001158 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 306263001159 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 306263001160 FlgN protein; Region: FlgN; pfam05130 306263001161 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 306263001162 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 306263001163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 306263001164 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 306263001165 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 306263001166 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 306263001167 thiamine monophosphate kinase; Provisional; Region: PRK05731 306263001168 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 306263001169 ATP binding site [chemical binding]; other site 306263001170 dimerization interface [polypeptide binding]; other site 306263001171 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 306263001172 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 306263001173 Permutation of conserved domain; other site 306263001174 active site 306263001175 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 306263001176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4378 306263001177 flavodoxin FldA; Validated; Region: PRK09267 306263001178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 306263001179 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 306263001180 dUTPase; Region: dUTPase_2; pfam08761 306263001181 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 306263001182 active site 306263001183 homodimer interface [polypeptide binding]; other site 306263001184 metal binding site [ion binding]; metal-binding site 306263001185 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 306263001186 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 306263001187 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 306263001188 triosephosphate isomerase; Provisional; Region: PRK14565 306263001189 substrate binding site [chemical binding]; other site 306263001190 dimer interface [polypeptide binding]; other site 306263001191 catalytic triad [active] 306263001192 Phosphoglycerate kinase; Region: PGK; pfam00162 306263001193 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 306263001194 substrate binding site [chemical binding]; other site 306263001195 hinge regions; other site 306263001196 ADP binding site [chemical binding]; other site 306263001197 catalytic site [active] 306263001198 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 306263001199 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 306263001200 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 306263001201 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 306263001202 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 306263001203 active site 306263001204 (T/H)XGH motif; other site 306263001205 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 306263001206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001207 binding surface 306263001208 TPR motif; other site 306263001209 TPR repeat; Region: TPR_11; pfam13414 306263001210 TPR repeat; Region: TPR_11; pfam13414 306263001211 TPR repeat; Region: TPR_11; pfam13414 306263001212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001213 binding surface 306263001214 TPR motif; other site 306263001215 TPR repeat; Region: TPR_11; pfam13414 306263001216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001217 binding surface 306263001218 TPR motif; other site 306263001219 Tetratricopeptide repeat; Region: TPR_16; pfam13432 306263001220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001221 TPR repeat; Region: TPR_11; pfam13414 306263001222 binding surface 306263001223 TPR motif; other site 306263001224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001225 binding surface 306263001226 TPR repeat; Region: TPR_11; pfam13414 306263001227 TPR motif; other site 306263001228 TPR repeat; Region: TPR_11; pfam13414 306263001229 TPR repeat; Region: TPR_11; pfam13414 306263001230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001231 binding surface 306263001232 TPR motif; other site 306263001233 Tetratricopeptide repeat; Region: TPR_12; pfam13424 306263001234 Tetratricopeptide repeat; Region: TPR_12; pfam13424 306263001235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001236 binding surface 306263001237 TPR motif; other site 306263001238 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 306263001239 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 306263001240 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 306263001241 fumarate hydratase; Reviewed; Region: fumC; PRK00485 306263001242 Class II fumarases; Region: Fumarase_classII; cd01362 306263001243 active site 306263001244 tetramer interface [polypeptide binding]; other site 306263001245 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 306263001246 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 306263001247 glutaminase active site [active] 306263001248 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 306263001249 dimer interface [polypeptide binding]; other site 306263001250 active site 306263001251 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 306263001252 dimer interface [polypeptide binding]; other site 306263001253 active site 306263001254 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 306263001255 hypothetical protein; Provisional; Region: PRK08444 306263001256 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 306263001257 FeS/SAM binding site; other site 306263001258 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 306263001259 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 306263001260 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306263001261 active site 306263001262 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 306263001263 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 306263001264 molybdopterin cofactor binding site; other site 306263001265 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 306263001266 molybdopterin cofactor binding site; other site 306263001267 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 306263001268 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 306263001269 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 306263001270 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 306263001271 Protein of unknown function (DUF328); Region: DUF328; pfam03883 306263001272 elongation factor Tu; Reviewed; Region: PRK00049 306263001273 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 306263001274 G1 box; other site 306263001275 GEF interaction site [polypeptide binding]; other site 306263001276 GTP/Mg2+ binding site [chemical binding]; other site 306263001277 Switch I region; other site 306263001278 G2 box; other site 306263001279 G3 box; other site 306263001280 Switch II region; other site 306263001281 G4 box; other site 306263001282 G5 box; other site 306263001283 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 306263001284 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 306263001285 Antibiotic Binding Site [chemical binding]; other site 306263001286 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 306263001287 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 306263001288 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 306263001289 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 306263001290 putative homodimer interface [polypeptide binding]; other site 306263001291 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 306263001292 heterodimer interface [polypeptide binding]; other site 306263001293 homodimer interface [polypeptide binding]; other site 306263001294 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 306263001295 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 306263001296 23S rRNA interface [nucleotide binding]; other site 306263001297 L7/L12 interface [polypeptide binding]; other site 306263001298 putative thiostrepton binding site; other site 306263001299 L25 interface [polypeptide binding]; other site 306263001300 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 306263001301 mRNA/rRNA interface [nucleotide binding]; other site 306263001302 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 306263001303 23S rRNA interface [nucleotide binding]; other site 306263001304 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 306263001305 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 306263001306 L11 interface [polypeptide binding]; other site 306263001307 putative EF-Tu interaction site [polypeptide binding]; other site 306263001308 putative EF-G interaction site [polypeptide binding]; other site 306263001309 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 306263001310 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 306263001311 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 306263001312 RPB11 interaction site [polypeptide binding]; other site 306263001313 RPB12 interaction site [polypeptide binding]; other site 306263001314 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 306263001315 RPB3 interaction site [polypeptide binding]; other site 306263001316 RPB1 interaction site [polypeptide binding]; other site 306263001317 RPB11 interaction site [polypeptide binding]; other site 306263001318 RPB10 interaction site [polypeptide binding]; other site 306263001319 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 306263001320 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 306263001321 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 306263001322 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 306263001323 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 306263001324 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 306263001325 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 306263001326 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 306263001327 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 306263001328 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 306263001329 DNA binding site [nucleotide binding] 306263001330 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 306263001331 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 306263001332 S17 interaction site [polypeptide binding]; other site 306263001333 S8 interaction site; other site 306263001334 16S rRNA interaction site [nucleotide binding]; other site 306263001335 streptomycin interaction site [chemical binding]; other site 306263001336 23S rRNA interaction site [nucleotide binding]; other site 306263001337 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 306263001338 30S ribosomal protein S7; Validated; Region: PRK05302 306263001339 elongation factor G; Reviewed; Region: PRK00007 306263001340 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 306263001341 G1 box; other site 306263001342 putative GEF interaction site [polypeptide binding]; other site 306263001343 GTP/Mg2+ binding site [chemical binding]; other site 306263001344 Switch I region; other site 306263001345 G2 box; other site 306263001346 G3 box; other site 306263001347 Switch II region; other site 306263001348 G4 box; other site 306263001349 G5 box; other site 306263001350 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 306263001351 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 306263001352 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 306263001353 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 306263001354 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 306263001355 Domain of unknown function DUF21; Region: DUF21; pfam01595 306263001356 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 306263001357 Transporter associated domain; Region: CorC_HlyC; smart01091 306263001358 putative transporter; Reviewed; Region: PRK12369 306263001359 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 306263001360 Na binding site [ion binding]; other site 306263001361 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 306263001362 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 306263001363 NAD(P) binding pocket [chemical binding]; other site 306263001364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263001365 dimer interface [polypeptide binding]; other site 306263001366 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 306263001367 conserved gate region; other site 306263001368 putative PBP binding loops; other site 306263001369 ABC-ATPase subunit interface; other site 306263001370 Predicted metal-binding protein [General function prediction only]; Region: COG3019 306263001371 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 306263001372 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 306263001373 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 306263001374 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 306263001375 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 306263001376 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 306263001377 N-terminal plug; other site 306263001378 ligand-binding site [chemical binding]; other site 306263001379 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08451 306263001380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263001381 Walker A motif; other site 306263001382 ATP binding site [chemical binding]; other site 306263001383 Walker B motif; other site 306263001384 transcription termination factor Rho; Provisional; Region: rho; PRK09376 306263001385 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 306263001386 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 306263001387 RNA binding site [nucleotide binding]; other site 306263001388 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 306263001389 multimer interface [polypeptide binding]; other site 306263001390 Walker A motif; other site 306263001391 ATP binding site [chemical binding]; other site 306263001392 Walker B motif; other site 306263001393 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 306263001394 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 306263001395 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 306263001396 metal-binding site [ion binding] 306263001397 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 306263001398 Soluble P-type ATPase [General function prediction only]; Region: COG4087 306263001399 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 306263001400 Cytochrome c; Region: Cytochrom_C; cl11414 306263001401 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 306263001402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263001403 active site 306263001404 motif I; other site 306263001405 motif II; other site 306263001406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263001407 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 306263001408 NAD(P) binding site [chemical binding]; other site 306263001409 active site 306263001410 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 306263001411 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 306263001412 putative ribose interaction site [chemical binding]; other site 306263001413 putative ADP binding site [chemical binding]; other site 306263001414 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 306263001415 active site 306263001416 nucleotide binding site [chemical binding]; other site 306263001417 HIGH motif; other site 306263001418 KMSKS motif; other site 306263001419 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 306263001420 dimer interface [polypeptide binding]; other site 306263001421 active site 306263001422 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 306263001423 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 306263001424 domain interfaces; other site 306263001425 active site 306263001426 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 306263001427 Predicted dehydrogenase [General function prediction only]; Region: COG0579 306263001428 pantothenate kinase; Reviewed; Region: PRK13333 306263001429 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 306263001430 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 306263001431 Colicin V production protein; Region: Colicin_V; pfam02674 306263001432 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 306263001433 metal binding site 2 [ion binding]; metal-binding site 306263001434 putative DNA binding helix; other site 306263001435 metal binding site 1 [ion binding]; metal-binding site 306263001436 dimer interface [polypeptide binding]; other site 306263001437 structural Zn2+ binding site [ion binding]; other site 306263001438 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 306263001439 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 306263001440 dimer interface [polypeptide binding]; other site 306263001441 putative anticodon binding site; other site 306263001442 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 306263001443 motif 1; other site 306263001444 active site 306263001445 motif 2; other site 306263001446 motif 3; other site 306263001447 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 306263001448 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 306263001449 dimer interface [polypeptide binding]; other site 306263001450 active site 306263001451 glycine-pyridoxal phosphate binding site [chemical binding]; other site 306263001452 folate binding site [chemical binding]; other site 306263001453 Domain of unknown function (DUF1882); Region: DUF1882; pfam08966 306263001454 Sporulation related domain; Region: SPOR; pfam05036 306263001455 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 306263001456 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 306263001457 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 306263001458 shikimate binding site; other site 306263001459 NAD(P) binding site [chemical binding]; other site 306263001460 chaperone protein DnaJ; Provisional; Region: PRK10767 306263001461 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 306263001462 HSP70 interaction site [polypeptide binding]; other site 306263001463 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 306263001464 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 306263001465 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 306263001466 dimer interface [polypeptide binding]; other site 306263001467 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306263001468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263001469 active site 306263001470 phosphorylation site [posttranslational modification] 306263001471 intermolecular recognition site; other site 306263001472 dimerization interface [polypeptide binding]; other site 306263001473 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 306263001474 DNA binding site [nucleotide binding] 306263001475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 306263001476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 306263001477 dimer interface [polypeptide binding]; other site 306263001478 phosphorylation site [posttranslational modification] 306263001479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263001480 ATP binding site [chemical binding]; other site 306263001481 Mg2+ binding site [ion binding]; other site 306263001482 G-X-G motif; other site 306263001483 recombination protein RecR; Reviewed; Region: recR; PRK00076 306263001484 RecR protein; Region: RecR; pfam02132 306263001485 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 306263001486 putative active site [active] 306263001487 putative metal-binding site [ion binding]; other site 306263001488 tetramer interface [polypeptide binding]; other site 306263001489 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 306263001490 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 306263001491 GIY-YIG motif/motif A; other site 306263001492 active site 306263001493 catalytic site [active] 306263001494 putative DNA binding site [nucleotide binding]; other site 306263001495 metal binding site [ion binding]; metal-binding site 306263001496 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 306263001497 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 306263001498 Citrate transporter; Region: CitMHS; pfam03600 306263001499 GMP synthase; Reviewed; Region: guaA; PRK00074 306263001500 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 306263001501 AMP/PPi binding site [chemical binding]; other site 306263001502 candidate oxyanion hole; other site 306263001503 catalytic triad [active] 306263001504 potential glutamine specificity residues [chemical binding]; other site 306263001505 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 306263001506 ATP Binding subdomain [chemical binding]; other site 306263001507 Ligand Binding sites [chemical binding]; other site 306263001508 Dimerization subdomain; other site 306263001509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263001510 S-adenosylmethionine binding site [chemical binding]; other site 306263001511 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 306263001512 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 306263001513 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 306263001514 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 306263001515 RDD family; Region: RDD; pfam06271 306263001516 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 306263001517 Organic solvent tolerance protein; Region: OstA_C; pfam04453 306263001518 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 306263001519 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 306263001520 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 306263001521 oligomer interface [polypeptide binding]; other site 306263001522 RNA binding site [nucleotide binding]; other site 306263001523 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 306263001524 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 306263001525 RNase E interface [polypeptide binding]; other site 306263001526 trimer interface [polypeptide binding]; other site 306263001527 active site 306263001528 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 306263001529 putative nucleic acid binding region [nucleotide binding]; other site 306263001530 G-X-X-G motif; other site 306263001531 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 306263001532 RNA binding site [nucleotide binding]; other site 306263001533 AAA domain; Region: AAA_30; pfam13604 306263001534 PIF1-like helicase; Region: PIF1; pfam05970 306263001535 Helicase; Region: Herpes_Helicase; pfam02689 306263001536 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 306263001537 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 306263001538 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 306263001539 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 306263001540 DEAD/DEAH box helicase; Region: DEAD; pfam00270 306263001541 ATP binding site [chemical binding]; other site 306263001542 putative Mg++ binding site [ion binding]; other site 306263001543 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 306263001544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306263001545 nucleotide binding region [chemical binding]; other site 306263001546 ATP-binding site [chemical binding]; other site 306263001547 SEC-C motif; Region: SEC-C; pfam02810 306263001548 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 306263001549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263001550 active site 306263001551 phosphorylation site [posttranslational modification] 306263001552 intermolecular recognition site; other site 306263001553 dimerization interface [polypeptide binding]; other site 306263001554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263001555 Walker A motif; other site 306263001556 ATP binding site [chemical binding]; other site 306263001557 Walker B motif; other site 306263001558 arginine finger; other site 306263001559 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 306263001560 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 306263001561 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 306263001562 Predicted membrane protein [Function unknown]; Region: COG2862 306263001563 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 306263001564 substrate binding site [chemical binding]; other site 306263001565 active site 306263001566 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 306263001567 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263001568 FeS/SAM binding site; other site 306263001569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001570 binding surface 306263001571 TPR motif; other site 306263001572 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 306263001573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 306263001574 binding surface 306263001575 TPR motif; other site 306263001576 seryl-tRNA synthetase; Provisional; Region: PRK05431 306263001577 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 306263001578 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 306263001579 dimer interface [polypeptide binding]; other site 306263001580 active site 306263001581 motif 1; other site 306263001582 motif 2; other site 306263001583 motif 3; other site 306263001584 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 306263001585 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 306263001586 active site 306263001587 HIGH motif; other site 306263001588 dimer interface [polypeptide binding]; other site 306263001589 KMSKS motif; other site 306263001590 shikimate kinase; Reviewed; Region: aroK; PRK00131 306263001591 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 306263001592 ADP binding site [chemical binding]; other site 306263001593 magnesium binding site [ion binding]; other site 306263001594 putative shikimate binding site; other site 306263001595 GTP-binding protein Der; Reviewed; Region: PRK00093 306263001596 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 306263001597 G1 box; other site 306263001598 GTP/Mg2+ binding site [chemical binding]; other site 306263001599 Switch I region; other site 306263001600 G2 box; other site 306263001601 Switch II region; other site 306263001602 G3 box; other site 306263001603 G4 box; other site 306263001604 G5 box; other site 306263001605 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 306263001606 G1 box; other site 306263001607 GTP/Mg2+ binding site [chemical binding]; other site 306263001608 Switch I region; other site 306263001609 G2 box; other site 306263001610 G3 box; other site 306263001611 Switch II region; other site 306263001612 G4 box; other site 306263001613 G5 box; other site 306263001614 EamA-like transporter family; Region: EamA; pfam00892 306263001615 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 306263001616 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 306263001617 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 306263001618 homopentamer interface [polypeptide binding]; other site 306263001619 active site 306263001620 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 306263001621 putative RNA binding site [nucleotide binding]; other site 306263001622 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 306263001623 active site 306263001624 dimer interface [polypeptide binding]; other site 306263001625 META domain; Region: META; pfam03724 306263001626 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 306263001627 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 306263001628 dimerization interface [polypeptide binding]; other site 306263001629 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263001630 dimer interface [polypeptide binding]; other site 306263001631 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 306263001632 putative CheW interface [polypeptide binding]; other site 306263001633 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 306263001634 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 306263001635 purine monophosphate binding site [chemical binding]; other site 306263001636 dimer interface [polypeptide binding]; other site 306263001637 putative catalytic residues [active] 306263001638 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 306263001639 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 306263001640 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 306263001641 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 306263001642 putative metal binding site [ion binding]; other site 306263001643 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 306263001644 HSP70 interaction site [polypeptide binding]; other site 306263001645 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 306263001646 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 306263001647 dimerization interface [polypeptide binding]; other site 306263001648 ATP binding site [chemical binding]; other site 306263001649 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 306263001650 dimerization interface [polypeptide binding]; other site 306263001651 ATP binding site [chemical binding]; other site 306263001652 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 306263001653 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 306263001654 trmE is a tRNA modification GTPase; Region: trmE; cd04164 306263001655 G1 box; other site 306263001656 GTP/Mg2+ binding site [chemical binding]; other site 306263001657 Switch I region; other site 306263001658 G2 box; other site 306263001659 Switch II region; other site 306263001660 G3 box; other site 306263001661 G4 box; other site 306263001662 G5 box; other site 306263001663 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 306263001664 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 306263001665 membrane protein insertase; Provisional; Region: PRK01318 306263001666 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 306263001667 Haemolytic domain; Region: Haemolytic; pfam01809 306263001668 RNase P protein component [Translation, ribosomal structure and biogenesis]; Region: RnpA; COG0594 306263001669 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 306263001670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 306263001671 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 306263001672 Coenzyme A binding pocket [chemical binding]; other site 306263001673 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_2; cd10034 306263001674 putative uracil binding site [chemical binding]; other site 306263001675 putative active site [active] 306263001676 DDE superfamily endonuclease; Region: DDE_5; cl17874 306263001677 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 306263001678 active site 306263001679 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 306263001680 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 306263001681 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 306263001682 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 306263001683 catalytic residues [active] 306263001684 hinge region; other site 306263001685 alpha helical domain; other site 306263001686 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 306263001687 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 306263001688 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 306263001689 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 306263001690 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 306263001691 metal binding site [ion binding]; metal-binding site 306263001692 Staphylococcal nuclease homologues; Region: SNc; smart00318 306263001693 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 306263001694 Catalytic site; other site 306263001695 Methyltransferase domain; Region: Methyltransf_31; pfam13847 306263001696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263001697 S-adenosylmethionine binding site [chemical binding]; other site 306263001698 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 306263001699 flagellin; Provisional; Region: PRK12804 306263001700 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 306263001701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263001702 S-adenosylmethionine binding site [chemical binding]; other site 306263001703 Peptidase family M48; Region: Peptidase_M48; pfam01435 306263001704 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 306263001705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306263001706 Walker A/P-loop; other site 306263001707 ATP binding site [chemical binding]; other site 306263001708 Q-loop/lid; other site 306263001709 ABC transporter signature motif; other site 306263001710 Walker B; other site 306263001711 D-loop; other site 306263001712 H-loop/switch region; other site 306263001713 ABC transporter; Region: ABC_tran_2; pfam12848 306263001714 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 306263001715 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 306263001716 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 306263001717 putative active site [active] 306263001718 putative metal binding site [ion binding]; other site 306263001719 phosphatidylserine decarboxylase; Provisional; Region: PRK03934 306263001720 flhB C-terminus-related protein; Region: flhB_rel; TIGR00789 306263001721 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 306263001722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263001723 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306263001724 putative substrate translocation pore; other site 306263001725 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 306263001726 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 306263001727 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 306263001728 inhibitor-cofactor binding pocket; inhibition site 306263001729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263001730 catalytic residue [active] 306263001731 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 306263001732 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14166 306263001733 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 306263001734 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 306263001735 homodimer interface [polypeptide binding]; other site 306263001736 NADP binding site [chemical binding]; other site 306263001737 substrate binding site [chemical binding]; other site 306263001738 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 306263001739 signal peptidase I; Provisional; Region: PRK10861 306263001740 Catalytic site [active] 306263001741 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 306263001742 aspartate aminotransferase; Provisional; Region: PRK05764 306263001743 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 306263001744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263001745 homodimer interface [polypeptide binding]; other site 306263001746 catalytic residue [active] 306263001747 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 306263001748 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 306263001749 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 306263001750 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 306263001751 acetyl-CoA carboxylase subunit A; Validated; Region: PRK08463 306263001752 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 306263001753 ATP-grasp domain; Region: ATP-grasp_4; cl17255 306263001754 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 306263001755 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 306263001756 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 306263001757 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 306263001758 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 306263001759 HSP70 interaction site [polypeptide binding]; other site 306263001760 cell division protein FtsW; Region: ftsW; TIGR02614 306263001761 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 306263001762 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 306263001763 substrate binding pocket [chemical binding]; other site 306263001764 membrane-bound complex binding site; other site 306263001765 hinge residues; other site 306263001766 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 306263001767 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 306263001768 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306263001769 catalytic residue [active] 306263001770 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 306263001771 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 306263001772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 306263001773 dimer interface [polypeptide binding]; other site 306263001774 phosphorylation site [posttranslational modification] 306263001775 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 306263001776 ATP binding site [chemical binding]; other site 306263001777 Mg2+ binding site [ion binding]; other site 306263001778 G-X-G motif; other site 306263001779 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 306263001780 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 306263001781 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 306263001782 Walker A/P-loop; other site 306263001783 ATP binding site [chemical binding]; other site 306263001784 Q-loop/lid; other site 306263001785 ABC transporter signature motif; other site 306263001786 Walker B; other site 306263001787 D-loop; other site 306263001788 H-loop/switch region; other site 306263001789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263001790 dimer interface [polypeptide binding]; other site 306263001791 conserved gate region; other site 306263001792 putative PBP binding loops; other site 306263001793 ABC-ATPase subunit interface; other site 306263001794 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 306263001795 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 306263001796 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 306263001797 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 306263001798 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 306263001799 Peptidase family M23; Region: Peptidase_M23; pfam01551 306263001800 Uncharacterized conserved protein [Function unknown]; Region: COG1565 306263001801 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 306263001802 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 306263001803 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 306263001804 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 306263001805 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 306263001806 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 306263001807 active site 306263001808 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 306263001809 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 306263001810 Interdomain contacts; other site 306263001811 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 306263001812 Interdomain contacts; other site 306263001813 Cytokine receptor motif; other site 306263001814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263001815 S-adenosylmethionine binding site [chemical binding]; other site 306263001816 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 306263001817 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 306263001818 Walker A/P-loop; other site 306263001819 ATP binding site [chemical binding]; other site 306263001820 Q-loop/lid; other site 306263001821 ABC transporter signature motif; other site 306263001822 Walker B; other site 306263001823 D-loop; other site 306263001824 H-loop/switch region; other site 306263001825 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 306263001826 Peptidase family M23; Region: Peptidase_M23; pfam01551 306263001827 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 306263001828 putative nucleotide binding site [chemical binding]; other site 306263001829 uridine monophosphate binding site [chemical binding]; other site 306263001830 homohexameric interface [polypeptide binding]; other site 306263001831 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 306263001832 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 306263001833 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 306263001834 Zn2+ binding site [ion binding]; other site 306263001835 Mg2+ binding site [ion binding]; other site 306263001836 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 306263001837 synthetase active site [active] 306263001838 NTP binding site [chemical binding]; other site 306263001839 metal binding site [ion binding]; metal-binding site 306263001840 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 306263001841 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 306263001842 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 306263001843 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 306263001844 active site 306263001845 HIGH motif; other site 306263001846 dimer interface [polypeptide binding]; other site 306263001847 KMSKS motif; other site 306263001848 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 306263001849 RNA binding surface [nucleotide binding]; other site 306263001850 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 306263001851 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 306263001852 FMN binding site [chemical binding]; other site 306263001853 substrate binding site [chemical binding]; other site 306263001854 putative catalytic residue [active] 306263001855 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 306263001856 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 306263001857 active site 306263001858 metal binding site [ion binding]; metal-binding site 306263001859 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 306263001860 Uncharacterized conserved protein [Function unknown]; Region: COG4121 306263001861 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 306263001862 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 306263001863 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 306263001864 active site 306263001865 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 306263001866 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 306263001867 putative substrate binding region [chemical binding]; other site 306263001868 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 306263001869 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 306263001870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263001871 NAD(P) binding site [chemical binding]; other site 306263001872 active site 306263001873 dihydrodipicolinate synthase; Region: dapA; TIGR00674 306263001874 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 306263001875 dimer interface [polypeptide binding]; other site 306263001876 active site 306263001877 catalytic residue [active] 306263001878 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 306263001879 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 306263001880 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 306263001881 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 306263001882 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 306263001883 quinone interaction residues [chemical binding]; other site 306263001884 active site 306263001885 catalytic residues [active] 306263001886 FMN binding site [chemical binding]; other site 306263001887 substrate binding site [chemical binding]; other site 306263001888 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 306263001889 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 306263001890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306263001891 Walker A/P-loop; other site 306263001892 ATP binding site [chemical binding]; other site 306263001893 Q-loop/lid; other site 306263001894 ABC transporter signature motif; other site 306263001895 Walker B; other site 306263001896 D-loop; other site 306263001897 H-loop/switch region; other site 306263001898 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 306263001899 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 306263001900 active site 306263001901 HIGH motif; other site 306263001902 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 306263001903 KMSKS motif; other site 306263001904 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 306263001905 tRNA binding surface [nucleotide binding]; other site 306263001906 anticodon binding site; other site 306263001907 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 306263001908 Protein of unknown function (DUF342); Region: DUF342; pfam03961 306263001909 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14601 306263001910 RuvA N terminal domain; Region: RuvA_N; pfam01330 306263001911 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 306263001912 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 306263001913 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 306263001914 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 306263001915 ATP-grasp domain; Region: ATP-grasp_4; cl17255 306263001916 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 306263001917 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 306263001918 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 306263001919 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306263001920 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 306263001921 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 306263001922 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 306263001923 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 306263001924 propionate/acetate kinase; Provisional; Region: PRK12379 306263001925 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 306263001926 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 306263001927 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 306263001928 active site 306263001929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263001930 dimer interface [polypeptide binding]; other site 306263001931 conserved gate region; other site 306263001932 ABC-ATPase subunit interface; other site 306263001933 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 306263001934 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 306263001935 Walker A/P-loop; other site 306263001936 ATP binding site [chemical binding]; other site 306263001937 Q-loop/lid; other site 306263001938 ABC transporter signature motif; other site 306263001939 Walker B; other site 306263001940 D-loop; other site 306263001941 H-loop/switch region; other site 306263001942 NIL domain; Region: NIL; pfam09383 306263001943 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 306263001944 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306263001945 active site 306263001946 HIGH motif; other site 306263001947 nucleotide binding site [chemical binding]; other site 306263001948 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 306263001949 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 306263001950 active site 306263001951 KMSKS motif; other site 306263001952 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 306263001953 tRNA binding surface [nucleotide binding]; other site 306263001954 anticodon binding site; other site 306263001955 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 306263001956 OmpA family; Region: OmpA; pfam00691 306263001957 ligand binding site [chemical binding]; other site 306263001958 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 306263001959 dimer interface [polypeptide binding]; other site 306263001960 substrate binding site [chemical binding]; other site 306263001961 metal binding sites [ion binding]; metal-binding site 306263001962 adenylate kinase; Reviewed; Region: adk; PRK00279 306263001963 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 306263001964 AMP-binding site [chemical binding]; other site 306263001965 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 306263001966 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 306263001967 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 306263001968 dimer interface [polypeptide binding]; other site 306263001969 anticodon binding site; other site 306263001970 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 306263001971 homodimer interface [polypeptide binding]; other site 306263001972 motif 1; other site 306263001973 active site 306263001974 motif 2; other site 306263001975 GAD domain; Region: GAD; pfam02938 306263001976 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 306263001977 active site 306263001978 motif 3; other site 306263001979 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 306263001980 ATP-NAD kinase; Region: NAD_kinase; pfam01513 306263001981 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 306263001982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306263001983 Walker A/P-loop; other site 306263001984 ATP binding site [chemical binding]; other site 306263001985 Q-loop/lid; other site 306263001986 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 306263001987 ABC transporter signature motif; other site 306263001988 Walker B; other site 306263001989 D-loop; other site 306263001990 H-loop/switch region; other site 306263001991 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 306263001992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263001993 active site 306263001994 phosphorylation site [posttranslational modification] 306263001995 intermolecular recognition site; other site 306263001996 dimerization interface [polypeptide binding]; other site 306263001997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263001998 active site 306263001999 phosphorylation site [posttranslational modification] 306263002000 intermolecular recognition site; other site 306263002001 dimerization interface [polypeptide binding]; other site 306263002002 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 306263002003 metal binding site [ion binding]; metal-binding site 306263002004 active site 306263002005 I-site; other site 306263002006 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 306263002007 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 306263002008 active site 306263002009 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 306263002010 N-acetyl-D-glucosamine binding site [chemical binding]; other site 306263002011 catalytic residue [active] 306263002012 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 306263002013 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 306263002014 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 306263002015 Sporulation related domain; Region: SPOR; pfam05036 306263002016 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 306263002017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263002018 active site 306263002019 motif I; other site 306263002020 motif II; other site 306263002021 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 306263002022 OstA-like protein; Region: OstA; pfam03968 306263002023 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 306263002024 G1 box; other site 306263002025 GTP/Mg2+ binding site [chemical binding]; other site 306263002026 Switch I region; other site 306263002027 G2 box; other site 306263002028 G3 box; other site 306263002029 Switch II region; other site 306263002030 G4 box; other site 306263002031 G5 box; other site 306263002032 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 306263002033 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 306263002034 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 306263002035 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 306263002036 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 306263002037 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 306263002038 sec-independent translocase; Provisional; Region: PRK04098 306263002039 Predicted permeases [General function prediction only]; Region: COG0701 306263002040 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 306263002041 putative DNA binding site [nucleotide binding]; other site 306263002042 dimerization interface [polypeptide binding]; other site 306263002043 putative Zn2+ binding site [ion binding]; other site 306263002044 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 306263002045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263002046 FeS/SAM binding site; other site 306263002047 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 306263002048 putative active site [active] 306263002049 Ap4A binding site [chemical binding]; other site 306263002050 nudix motif; other site 306263002051 putative metal binding site [ion binding]; other site 306263002052 aspartate kinase; Reviewed; Region: PRK06635 306263002053 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 306263002054 putative nucleotide binding site [chemical binding]; other site 306263002055 putative catalytic residues [active] 306263002056 putative Mg ion binding site [ion binding]; other site 306263002057 putative aspartate binding site [chemical binding]; other site 306263002058 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 306263002059 putative allosteric regulatory site; other site 306263002060 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 306263002061 DNA replication regulator; Region: HobA; pfam12163 306263002062 DNA polymerase III subunit delta'; Validated; Region: PRK08485 306263002063 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 306263002064 dihydropteroate synthase; Region: DHPS; TIGR01496 306263002065 substrate binding pocket [chemical binding]; other site 306263002066 dimer interface [polypeptide binding]; other site 306263002067 inhibitor binding site; inhibition site 306263002068 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 306263002069 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 306263002070 nucleotide binding pocket [chemical binding]; other site 306263002071 K-X-D-G motif; other site 306263002072 catalytic site [active] 306263002073 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 306263002074 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 306263002075 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 306263002076 Dimer interface [polypeptide binding]; other site 306263002077 BRCT sequence motif; other site 306263002078 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 306263002079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263002080 S-adenosylmethionine binding site [chemical binding]; other site 306263002081 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 306263002082 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306263002083 active site 306263002084 nucleotide binding site [chemical binding]; other site 306263002085 HIGH motif; other site 306263002086 KMSKS motif; other site 306263002087 Riboflavin kinase; Region: Flavokinase; pfam01687 306263002088 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 306263002089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263002090 S-adenosylmethionine binding site [chemical binding]; other site 306263002091 GTP-binding protein YchF; Reviewed; Region: PRK09601 306263002092 YchF GTPase; Region: YchF; cd01900 306263002093 G1 box; other site 306263002094 GTP/Mg2+ binding site [chemical binding]; other site 306263002095 Switch I region; other site 306263002096 G2 box; other site 306263002097 Switch II region; other site 306263002098 G3 box; other site 306263002099 G4 box; other site 306263002100 G5 box; other site 306263002101 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 306263002102 multifunctional aminopeptidase A; Provisional; Region: PRK00913 306263002103 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 306263002104 interface (dimer of trimers) [polypeptide binding]; other site 306263002105 Substrate-binding/catalytic site; other site 306263002106 Zn-binding sites [ion binding]; other site 306263002107 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 306263002108 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 306263002109 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306263002110 active site 306263002111 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 306263002112 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 306263002113 CheB methylesterase; Region: CheB_methylest; pfam01339 306263002114 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 306263002115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263002116 S-adenosylmethionine binding site [chemical binding]; other site 306263002117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263002118 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306263002119 putative substrate translocation pore; other site 306263002120 hypothetical protein; Provisional; Region: PRK08445 306263002121 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 306263002122 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 306263002123 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 306263002124 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 306263002125 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 306263002126 generic binding surface II; other site 306263002127 ssDNA binding site; other site 306263002128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306263002129 ATP binding site [chemical binding]; other site 306263002130 putative Mg++ binding site [ion binding]; other site 306263002131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306263002132 nucleotide binding region [chemical binding]; other site 306263002133 ATP-binding site [chemical binding]; other site 306263002134 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 306263002135 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 306263002136 ligand binding site [chemical binding]; other site 306263002137 flexible hinge region; other site 306263002138 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 306263002139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263002140 dimer interface [polypeptide binding]; other site 306263002141 conserved gate region; other site 306263002142 putative PBP binding loops; other site 306263002143 ABC-ATPase subunit interface; other site 306263002144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263002145 dimer interface [polypeptide binding]; other site 306263002146 conserved gate region; other site 306263002147 putative PBP binding loops; other site 306263002148 ABC-ATPase subunit interface; other site 306263002149 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 306263002150 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 306263002151 Walker A/P-loop; other site 306263002152 ATP binding site [chemical binding]; other site 306263002153 Q-loop/lid; other site 306263002154 ABC transporter signature motif; other site 306263002155 Walker B; other site 306263002156 D-loop; other site 306263002157 H-loop/switch region; other site 306263002158 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 306263002159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 306263002160 substrate binding pocket [chemical binding]; other site 306263002161 membrane-bound complex binding site; other site 306263002162 hinge residues; other site 306263002163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263002164 metabolite-proton symporter; Region: 2A0106; TIGR00883 306263002165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263002166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 306263002167 TrkA-C domain; Region: TrkA_C; pfam02080 306263002168 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 306263002169 active site 306263002170 dimer interface [polypeptide binding]; other site 306263002171 metal binding site [ion binding]; metal-binding site 306263002172 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 306263002173 Mechanosensitive ion channel; Region: MS_channel; pfam00924 306263002174 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 306263002175 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 306263002176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263002177 FeS/SAM binding site; other site 306263002178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263002179 Walker B motif; other site 306263002180 arginine finger; other site 306263002181 Peptidase family M41; Region: Peptidase_M41; pfam01434 306263002182 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 306263002183 MPT binding site; other site 306263002184 trimer interface [polypeptide binding]; other site 306263002185 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 306263002186 active site residue [active] 306263002187 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 306263002188 active site residue [active] 306263002189 heat shock protein 90; Provisional; Region: PRK05218 306263002190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263002191 ATP binding site [chemical binding]; other site 306263002192 Mg2+ binding site [ion binding]; other site 306263002193 G-X-G motif; other site 306263002194 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 306263002195 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 306263002196 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 306263002197 putative acyl-acceptor binding pocket; other site 306263002198 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 306263002199 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 306263002200 putative active site [active] 306263002201 catalytic triad [active] 306263002202 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 306263002203 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 306263002204 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 306263002205 ATP binding site [chemical binding]; other site 306263002206 active site 306263002207 substrate binding site [chemical binding]; other site 306263002208 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 306263002209 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 306263002210 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 306263002211 protein binding site [polypeptide binding]; other site 306263002212 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 306263002213 Catalytic dyad [active] 306263002214 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 306263002215 Clp amino terminal domain; Region: Clp_N; pfam02861 306263002216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263002217 Walker A motif; other site 306263002218 ATP binding site [chemical binding]; other site 306263002219 Walker B motif; other site 306263002220 arginine finger; other site 306263002221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263002222 Walker A motif; other site 306263002223 ATP binding site [chemical binding]; other site 306263002224 Walker B motif; other site 306263002225 arginine finger; other site 306263002226 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 306263002227 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 306263002228 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 306263002229 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 306263002230 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 306263002231 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 306263002232 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 306263002233 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 306263002234 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 306263002235 putative substrate-binding site; other site 306263002236 nickel binding site [ion binding]; other site 306263002237 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 306263002238 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 306263002239 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 306263002240 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306263002241 active site 306263002242 HIGH motif; other site 306263002243 nucleotide binding site [chemical binding]; other site 306263002244 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 306263002245 active site 306263002246 KMSKS motif; other site 306263002247 YGGT family; Region: YGGT; pfam02325 306263002248 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 306263002249 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 306263002250 N-acetyl-D-glucosamine binding site [chemical binding]; other site 306263002251 catalytic residue [active] 306263002252 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 306263002253 Walker A motif; other site 306263002254 fructose-1,6-bisphosphatase; Provisional; Region: PRK09293 306263002255 active site 306263002256 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 306263002257 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 306263002258 active site 306263002259 HIGH motif; other site 306263002260 KMSKS motif; other site 306263002261 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 306263002262 tRNA binding surface [nucleotide binding]; other site 306263002263 anticodon binding site; other site 306263002264 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 306263002265 putative tRNA-binding site [nucleotide binding]; other site 306263002266 dimer interface [polypeptide binding]; other site 306263002267 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 306263002268 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 306263002269 Uncharacterized conserved protein [Function unknown]; Region: COG2353 306263002270 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 306263002271 Ligand Binding Site [chemical binding]; other site 306263002272 metal-binding heat shock protein; Provisional; Region: PRK00016 306263002273 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 306263002274 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 306263002275 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 306263002276 Rhomboid family; Region: Rhomboid; pfam01694 306263002277 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 306263002278 catalytic core [active] 306263002279 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 306263002280 aspartate racemase; Region: asp_race; TIGR00035 306263002281 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 306263002282 active site 306263002283 DNA binding site [nucleotide binding] 306263002284 Int/Topo IB signature motif; other site 306263002285 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 306263002286 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 306263002287 hinge; other site 306263002288 active site 306263002289 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 306263002290 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 306263002291 dimer interface [polypeptide binding]; other site 306263002292 putative functional site; other site 306263002293 putative MPT binding site; other site 306263002294 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 306263002295 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515 306263002296 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 306263002297 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 306263002298 Flavoprotein; Region: Flavoprotein; pfam02441 306263002299 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 306263002300 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 306263002301 active site 306263002302 (T/H)XGH motif; other site 306263002303 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 306263002304 thymidylate kinase; Validated; Region: tmk; PRK00698 306263002305 TMP-binding site; other site 306263002306 ATP-binding site [chemical binding]; other site 306263002307 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 306263002308 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 306263002309 dimer interface [polypeptide binding]; other site 306263002310 motif 1; other site 306263002311 active site 306263002312 motif 2; other site 306263002313 motif 3; other site 306263002314 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 306263002315 anticodon binding site; other site 306263002316 arginine decarboxylase; Provisional; Region: PRK05354 306263002317 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 306263002318 dimer interface [polypeptide binding]; other site 306263002319 active site 306263002320 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306263002321 catalytic residues [active] 306263002322 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 306263002323 serine O-acetyltransferase; Region: cysE; TIGR01172 306263002324 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 306263002325 trimer interface [polypeptide binding]; other site 306263002326 active site 306263002327 substrate binding site [chemical binding]; other site 306263002328 CoA binding site [chemical binding]; other site 306263002329 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 306263002330 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 306263002331 active site 306263002332 homodimer interface [polypeptide binding]; other site 306263002333 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 306263002334 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306263002335 catalytic residue [active] 306263002336 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 306263002337 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 306263002338 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 306263002339 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 306263002340 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 306263002341 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 306263002342 Walker A/P-loop; other site 306263002343 ATP binding site [chemical binding]; other site 306263002344 Q-loop/lid; other site 306263002345 ABC transporter signature motif; other site 306263002346 Walker B; other site 306263002347 D-loop; other site 306263002348 H-loop/switch region; other site 306263002349 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 306263002350 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis]; Region: COG1188 306263002351 RNA binding surface [nucleotide binding]; other site 306263002352 argininosuccinate synthase; Provisional; Region: PRK13820 306263002353 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 306263002354 ANP binding site [chemical binding]; other site 306263002355 Substrate Binding Site II [chemical binding]; other site 306263002356 Substrate Binding Site I [chemical binding]; other site 306263002357 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 306263002358 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 306263002359 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 306263002360 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 306263002361 active site 306263002362 HslU subunit interaction site [polypeptide binding]; other site 306263002363 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 306263002364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263002365 Walker A motif; other site 306263002366 ATP binding site [chemical binding]; other site 306263002367 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 306263002368 Walker B motif; other site 306263002369 arginine finger; other site 306263002370 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 306263002371 GTPase Era; Reviewed; Region: era; PRK00089 306263002372 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 306263002373 G1 box; other site 306263002374 GTP/Mg2+ binding site [chemical binding]; other site 306263002375 Switch I region; other site 306263002376 G2 box; other site 306263002377 Switch II region; other site 306263002378 G3 box; other site 306263002379 G4 box; other site 306263002380 G5 box; other site 306263002381 KH domain; Region: KH_2; pfam07650 306263002382 flagellar protein FliS; Validated; Region: fliS; PRK05685 306263002383 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 306263002384 flagellar capping protein; Provisional; Region: PRK12765 306263002385 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 306263002386 FlaG protein; Region: FlaG; cl00591 306263002387 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 306263002388 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 306263002389 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 306263002390 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 306263002391 domain interfaces; other site 306263002392 active site 306263002393 prolyl-tRNA synthetase; Provisional; Region: PRK09194 306263002394 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 306263002395 dimer interface [polypeptide binding]; other site 306263002396 motif 1; other site 306263002397 active site 306263002398 motif 2; other site 306263002399 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 306263002400 putative deacylase active site [active] 306263002401 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 306263002402 active site 306263002403 motif 3; other site 306263002404 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 306263002405 anticodon binding site; other site 306263002406 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 306263002407 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 306263002408 tRNA; other site 306263002409 putative tRNA binding site [nucleotide binding]; other site 306263002410 putative NADP binding site [chemical binding]; other site 306263002411 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 306263002412 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 306263002413 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 306263002414 substrate binding pocket [chemical binding]; other site 306263002415 chain length determination region; other site 306263002416 substrate-Mg2+ binding site; other site 306263002417 catalytic residues [active] 306263002418 aspartate-rich region 1; other site 306263002419 active site lid residues [active] 306263002420 aspartate-rich region 2; other site 306263002421 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 306263002422 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 306263002423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263002424 motif II; other site 306263002425 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 306263002426 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 306263002427 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 306263002428 TrkA-N domain; Region: TrkA_N; pfam02254 306263002429 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 306263002430 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 306263002431 DNA binding residues [nucleotide binding] 306263002432 putative dimer interface [polypeptide binding]; other site 306263002433 chaperone protein DnaJ; Provisional; Region: PRK14299 306263002434 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 306263002435 HSP70 interaction site [polypeptide binding]; other site 306263002436 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 306263002437 substrate binding site [polypeptide binding]; other site 306263002438 dimer interface [polypeptide binding]; other site 306263002439 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 306263002440 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 306263002441 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 306263002442 protein binding site [polypeptide binding]; other site 306263002443 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 306263002444 protein binding site [polypeptide binding]; other site 306263002445 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306263002446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263002447 active site 306263002448 phosphorylation site [posttranslational modification] 306263002449 intermolecular recognition site; other site 306263002450 dimerization interface [polypeptide binding]; other site 306263002451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 306263002452 DNA binding site [nucleotide binding] 306263002453 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 306263002454 HAMP domain; Region: HAMP; pfam00672 306263002455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 306263002456 dimer interface [polypeptide binding]; other site 306263002457 phosphorylation site [posttranslational modification] 306263002458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263002459 ATP binding site [chemical binding]; other site 306263002460 Mg2+ binding site [ion binding]; other site 306263002461 G-X-G motif; other site 306263002462 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 306263002463 Part of AAA domain; Region: AAA_19; pfam13245 306263002464 Family description; Region: UvrD_C_2; pfam13538 306263002465 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 306263002466 dimer interface [polypeptide binding]; other site 306263002467 catalytic triad [active] 306263002468 peroxidatic and resolving cysteines [active] 306263002469 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 306263002470 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 306263002471 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 306263002472 methionine sulfoxide reductase A; Provisional; Region: PRK14054 306263002473 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 306263002474 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 306263002475 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 306263002476 dimerization interface [polypeptide binding]; other site 306263002477 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 306263002478 ATP binding site [chemical binding]; other site 306263002479 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 306263002480 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 306263002481 HupF/HypC family; Region: HupF_HypC; pfam01455 306263002482 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 306263002483 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 306263002484 Acylphosphatase; Region: Acylphosphatase; pfam00708 306263002485 HypF finger; Region: zf-HYPF; pfam07503 306263002486 HypF finger; Region: zf-HYPF; pfam07503 306263002487 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 306263002488 Protein of unknown function DUF45; Region: DUF45; pfam01863 306263002489 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 306263002490 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 306263002491 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 306263002492 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 306263002493 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14269 306263002494 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 306263002495 Walker A/P-loop; other site 306263002496 ATP binding site [chemical binding]; other site 306263002497 Q-loop/lid; other site 306263002498 ABC transporter signature motif; other site 306263002499 Walker B; other site 306263002500 D-loop; other site 306263002501 H-loop/switch region; other site 306263002502 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 306263002503 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 306263002504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263002505 dimer interface [polypeptide binding]; other site 306263002506 conserved gate region; other site 306263002507 putative PBP binding loops; other site 306263002508 ABC-ATPase subunit interface; other site 306263002509 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 306263002510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263002511 dimer interface [polypeptide binding]; other site 306263002512 conserved gate region; other site 306263002513 putative PBP binding loops; other site 306263002514 ABC-ATPase subunit interface; other site 306263002515 PBP superfamily domain; Region: PBP_like_2; cl17296 306263002516 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306263002517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263002518 active site 306263002519 phosphorylation site [posttranslational modification] 306263002520 intermolecular recognition site; other site 306263002521 dimerization interface [polypeptide binding]; other site 306263002522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 306263002523 DNA binding site [nucleotide binding] 306263002524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 306263002525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 306263002526 dimer interface [polypeptide binding]; other site 306263002527 phosphorylation site [posttranslational modification] 306263002528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263002529 ATP binding site [chemical binding]; other site 306263002530 Mg2+ binding site [ion binding]; other site 306263002531 G-X-G motif; other site 306263002532 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 306263002533 Ferritin-like domain; Region: Ferritin; pfam00210 306263002534 ferroxidase diiron center [ion binding]; other site 306263002535 Predicted transcriptional regulator [Transcription]; Region: COG2932 306263002536 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 306263002537 Catalytic site [active] 306263002538 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 306263002539 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 306263002540 active site residue [active] 306263002541 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 306263002542 heme-binding residues [chemical binding]; other site 306263002543 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 306263002544 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 306263002545 heme-binding residues [chemical binding]; other site 306263002546 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 306263002547 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 306263002548 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 306263002549 catalytic residues [active] 306263002550 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 306263002551 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 306263002552 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 306263002553 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 306263002554 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 306263002555 trimer interface [polypeptide binding]; other site 306263002556 active site 306263002557 UDP-GlcNAc binding site [chemical binding]; other site 306263002558 lipid binding site [chemical binding]; lipid-binding site 306263002559 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 306263002560 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 306263002561 putative valine binding site [chemical binding]; other site 306263002562 dimer interface [polypeptide binding]; other site 306263002563 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 306263002564 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527 306263002565 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 306263002566 PYR/PP interface [polypeptide binding]; other site 306263002567 dimer interface [polypeptide binding]; other site 306263002568 TPP binding site [chemical binding]; other site 306263002569 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 306263002570 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 306263002571 TPP-binding site [chemical binding]; other site 306263002572 dimer interface [polypeptide binding]; other site 306263002573 2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441 306263002574 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 306263002575 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 306263002576 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 306263002577 TPP-binding site [chemical binding]; other site 306263002578 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 306263002579 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 306263002580 dimer interface [polypeptide binding]; other site 306263002581 PYR/PP interface [polypeptide binding]; other site 306263002582 TPP binding site [chemical binding]; other site 306263002583 substrate binding site [chemical binding]; other site 306263002584 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 306263002585 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 306263002586 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 306263002587 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 306263002588 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 306263002589 NAD(P) binding site [chemical binding]; other site 306263002590 LDH/MDH dimer interface [polypeptide binding]; other site 306263002591 substrate binding site [chemical binding]; other site 306263002592 Protein of unknown function; Region: DUF3971; pfam13116 306263002593 AsmA-like C-terminal region; Region: AsmA_1; pfam13109 306263002594 YceG-like family; Region: YceG; pfam02618 306263002595 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 306263002596 dimerization interface [polypeptide binding]; other site 306263002597 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 306263002598 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 306263002599 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 306263002600 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 306263002601 alternative start site for ftsK 306263002602 lagellar hook-associated protein FlgL; Provisional; Region: PRK14692 306263002603 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 306263002604 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 306263002605 integrase; Provisional; Region: PRK09692 306263002606 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 306263002607 active site 306263002608 Int/Topo IB signature motif; other site 306263002609 Helix-turn-helix domain; Region: HTH_17; pfam12728 306263002610 Replication initiation factor; Region: Rep_trans; pfam02486 306263002611 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 306263002612 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 306263002613 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 306263002614 active site 306263002615 catalytic site [active] 306263002616 substrate binding site [chemical binding]; other site 306263002617 Uncharacterized conserved protein [Function unknown]; Region: COG4748 306263002618 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 306263002619 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 306263002620 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 306263002621 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 306263002622 ribonuclease Y; Region: RNase_Y; TIGR03319 306263002623 Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601 306263002624 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 306263002625 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 306263002626 Phage capsid family; Region: Phage_capsid; pfam05065 306263002627 phosphodiesterase; Provisional; Region: PRK12704 306263002628 Phage-related protein [Function unknown]; Region: COG4695 306263002629 Phage portal protein; Region: Phage_portal; pfam04860 306263002630 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 306263002631 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 306263002632 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 306263002633 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 306263002634 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 306263002635 active site 306263002636 Predicted transcriptional regulator [Transcription]; Region: COG2378 306263002637 HTH domain; Region: HTH_11; pfam08279 306263002638 WYL domain; Region: WYL; pfam13280 306263002639 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 306263002640 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 306263002641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263002642 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 306263002643 Walker A motif; other site 306263002644 ATP binding site [chemical binding]; other site 306263002645 Walker B motif; other site 306263002646 arginine finger; other site 306263002647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263002648 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 306263002649 Walker A motif; other site 306263002650 ATP binding site [chemical binding]; other site 306263002651 Walker B motif; other site 306263002652 arginine finger; other site 306263002653 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 306263002654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 306263002655 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 306263002656 Uncharacterized conserved protein [Function unknown]; Region: COG1479 306263002657 Protein of unknown function DUF262; Region: DUF262; pfam03235 306263002658 Protein of unknown function DUF262; Region: DUF262; pfam03235 306263002659 Uncharacterized conserved protein [Function unknown]; Region: COG1479 306263002660 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 306263002661 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 306263002662 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 306263002663 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 306263002664 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 306263002665 active site 306263002666 PHP Thumb interface [polypeptide binding]; other site 306263002667 metal binding site [ion binding]; metal-binding site 306263002668 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 306263002669 generic binding surface II; other site 306263002670 generic binding surface I; other site 306263002671 DJ-1 family protein; Region: not_thiJ; TIGR01383 306263002672 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 306263002673 conserved cys residue [active] 306263002674 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 306263002675 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 306263002676 putative active site; other site 306263002677 catalytic triad [active] 306263002678 putative dimer interface [polypeptide binding]; other site 306263002679 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 306263002680 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 306263002681 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 306263002682 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 306263002683 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 306263002684 NAD synthetase; Provisional; Region: PRK13980 306263002685 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 306263002686 homodimer interface [polypeptide binding]; other site 306263002687 NAD binding pocket [chemical binding]; other site 306263002688 ATP binding pocket [chemical binding]; other site 306263002689 Mg binding site [ion binding]; other site 306263002690 active-site loop [active] 306263002691 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 306263002692 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 306263002693 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 306263002694 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 306263002695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263002696 catalytic residue [active] 306263002697 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 306263002698 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 306263002699 Ligand binding site; other site 306263002700 oligomer interface; other site 306263002701 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 306263002702 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 306263002703 substrate binding pocket [chemical binding]; other site 306263002704 membrane-bound complex binding site; other site 306263002705 hinge residues; other site 306263002706 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 306263002707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263002708 dimer interface [polypeptide binding]; other site 306263002709 conserved gate region; other site 306263002710 putative PBP binding loops; other site 306263002711 ABC-ATPase subunit interface; other site 306263002712 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 306263002713 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 306263002714 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 306263002715 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 306263002716 DsbD alpha interface [polypeptide binding]; other site 306263002717 catalytic residues [active] 306263002718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 306263002719 MOSC domain; Region: MOSC; pfam03473 306263002720 3-alpha domain; Region: 3-alpha; pfam03475 306263002721 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 306263002722 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 306263002723 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 306263002724 Na2 binding site [ion binding]; other site 306263002725 putative substrate binding site 1 [chemical binding]; other site 306263002726 Na binding site 1 [ion binding]; other site 306263002727 putative substrate binding site 2 [chemical binding]; other site 306263002728 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 306263002729 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 306263002730 ligand binding site [chemical binding]; other site 306263002731 AAA domain; Region: AAA_13; pfam13166 306263002732 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 306263002733 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 306263002734 active site 306263002735 intersubunit interface [polypeptide binding]; other site 306263002736 zinc binding site [ion binding]; other site 306263002737 Na+ binding site [ion binding]; other site 306263002738 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 306263002739 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 306263002740 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 306263002741 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 306263002742 minor groove reading motif; other site 306263002743 helix-hairpin-helix signature motif; other site 306263002744 substrate binding pocket [chemical binding]; other site 306263002745 active site 306263002746 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 306263002747 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 306263002748 N terminus of Notch ligand; Region: MNNL; pfam07657 306263002749 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 306263002750 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 306263002751 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 306263002752 Walker A/P-loop; other site 306263002753 ATP binding site [chemical binding]; other site 306263002754 Q-loop/lid; other site 306263002755 ABC transporter signature motif; other site 306263002756 Walker B; other site 306263002757 D-loop; other site 306263002758 H-loop/switch region; other site 306263002759 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 306263002760 FtsX-like permease family; Region: FtsX; pfam02687 306263002761 macrolide transporter subunit MacA; Provisional; Region: PRK11578 306263002762 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 306263002763 HlyD family secretion protein; Region: HlyD_3; pfam13437 306263002764 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 306263002765 dimer interface [polypeptide binding]; other site 306263002766 FMN binding site [chemical binding]; other site 306263002767 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 306263002768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263002769 putative substrate translocation pore; other site 306263002770 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 306263002771 putative acyl-acceptor binding pocket; other site 306263002772 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 306263002773 acyl-activating enzyme (AAE) consensus motif; other site 306263002774 AMP binding site [chemical binding]; other site 306263002775 active site 306263002776 CoA binding site [chemical binding]; other site 306263002777 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 306263002778 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 306263002779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 306263002780 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 306263002781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263002782 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 306263002783 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 306263002784 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 306263002785 nucleotide binding site/active site [active] 306263002786 HIT family signature motif; other site 306263002787 catalytic residue [active] 306263002788 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 306263002789 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 306263002790 active site residue [active] 306263002791 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 306263002792 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 306263002793 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 306263002794 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946 306263002795 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 306263002796 active site 306263002797 hydrophilic channel; other site 306263002798 dimerization interface [polypeptide binding]; other site 306263002799 catalytic residues [active] 306263002800 active site lid [active] 306263002801 exopolyphosphatase; Region: exo_poly_only; TIGR03706 306263002802 Yqey-like protein; Region: YqeY; cl17540 306263002803 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 306263002804 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 306263002805 active site 306263002806 substrate binding site [chemical binding]; other site 306263002807 Mg2+ binding site [ion binding]; other site 306263002808 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 306263002809 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 306263002810 nucleotide binding site [chemical binding]; other site 306263002811 NEF interaction site [polypeptide binding]; other site 306263002812 SBD interface [polypeptide binding]; other site 306263002813 GrpE; Region: GrpE; pfam01025 306263002814 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 306263002815 dimer interface [polypeptide binding]; other site 306263002816 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 306263002817 heat-inducible transcription repressor; Provisional; Region: PRK03911 306263002818 DHH family; Region: DHH; pfam01368 306263002819 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 306263002820 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 306263002821 FHIPEP family; Region: FHIPEP; pfam00771 306263002822 Rrf2 family protein; Region: rrf2_super; TIGR00738 306263002823 Transcriptional regulator; Region: Rrf2; pfam02082 306263002824 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 306263002825 16S/18S rRNA binding site [nucleotide binding]; other site 306263002826 S13e-L30e interaction site [polypeptide binding]; other site 306263002827 25S rRNA binding site [nucleotide binding]; other site 306263002828 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 306263002829 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 306263002830 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 306263002831 DNA protecting protein DprA; Region: dprA; TIGR00732 306263002832 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 306263002833 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 306263002834 NodB motif; other site 306263002835 putative active site [active] 306263002836 putative catalytic site [active] 306263002837 Zn binding site [ion binding]; other site 306263002838 ketol-acid reductoisomerase; Provisional; Region: PRK05479 306263002839 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 306263002840 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 306263002841 Exoribonuclease R [Transcription]; Region: VacB; COG0557 306263002842 RNB domain; Region: RNB; pfam00773 306263002843 DNA polymerase III subunit delta; Validated; Region: PRK08487 306263002844 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 306263002845 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 306263002846 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 306263002847 dimer interface [polypeptide binding]; other site 306263002848 ssDNA binding site [nucleotide binding]; other site 306263002849 tetramer (dimer of dimers) interface [polypeptide binding]; other site 306263002850 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 306263002851 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 306263002852 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 306263002853 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 306263002854 flagellar assembly protein FliW; Provisional; Region: PRK13282 306263002855 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 306263002856 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 306263002857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263002858 Walker A motif; other site 306263002859 ATP binding site [chemical binding]; other site 306263002860 Walker B motif; other site 306263002861 arginine finger; other site 306263002862 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 306263002863 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263002864 dimer interface [polypeptide binding]; other site 306263002865 putative CheW interface [polypeptide binding]; other site 306263002866 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 306263002867 PAS domain; Region: PAS_9; pfam13426 306263002868 putative active site [active] 306263002869 heme pocket [chemical binding]; other site 306263002870 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 306263002871 PAS domain; Region: PAS_9; pfam13426 306263002872 putative active site [active] 306263002873 heme pocket [chemical binding]; other site 306263002874 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 306263002875 threonine dehydratase; Provisional; Region: PRK08526 306263002876 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 306263002877 tetramer interface [polypeptide binding]; other site 306263002878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263002879 catalytic residue [active] 306263002880 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 306263002881 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 306263002882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263002883 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306263002884 putative substrate translocation pore; other site 306263002885 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 306263002886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263002887 S-adenosylmethionine binding site [chemical binding]; other site 306263002888 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 306263002889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263002890 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 306263002891 NAD(P) binding site [chemical binding]; other site 306263002892 active site 306263002893 DsrC like protein; Region: DsrC; cl01101 306263002894 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 306263002895 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 306263002896 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 306263002897 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 306263002898 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 306263002899 DNA binding site [nucleotide binding] 306263002900 active site 306263002901 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 306263002902 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 306263002903 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 306263002904 dimerization interface 3.5A [polypeptide binding]; other site 306263002905 active site 306263002906 Predicted permeases [General function prediction only]; Region: COG0795 306263002907 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 306263002908 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 306263002909 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 306263002910 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 306263002911 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 306263002912 catalytic residue [active] 306263002913 putative FPP diphosphate binding site; other site 306263002914 putative FPP binding hydrophobic cleft; other site 306263002915 dimer interface [polypeptide binding]; other site 306263002916 putative IPP diphosphate binding site; other site 306263002917 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 306263002918 Flavoprotein; Region: Flavoprotein; pfam02441 306263002919 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 306263002920 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 306263002921 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 306263002922 Substrate binding site; other site 306263002923 Mg++ binding site; other site 306263002924 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 306263002925 active site 306263002926 substrate binding site [chemical binding]; other site 306263002927 CoA binding site [chemical binding]; other site 306263002928 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 306263002929 Predicted permeases [General function prediction only]; Region: COG0679 306263002930 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 306263002931 chorismate binding enzyme; Region: Chorismate_bind; cl10555 306263002932 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 306263002933 Aminotransferase class IV; Region: Aminotran_4; pfam01063 306263002934 substrate-cofactor binding pocket; other site 306263002935 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 306263002936 Glutamine amidotransferase class-I; Region: GATase; pfam00117 306263002937 glutamine binding [chemical binding]; other site 306263002938 catalytic triad [active] 306263002939 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 306263002940 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 306263002941 HlyD family secretion protein; Region: HlyD_3; pfam13437 306263002942 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 306263002943 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 306263002944 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 306263002945 Cupin domain; Region: Cupin_2; cl17218 306263002946 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 306263002947 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 306263002948 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14593 306263002949 RimM N-terminal domain; Region: RimM; pfam01782 306263002950 PRC-barrel domain; Region: PRC; pfam05239 306263002951 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 306263002952 KH domain; Region: KH_4; pfam13083 306263002953 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 306263002954 signal recognition particle protein; Provisional; Region: PRK10867 306263002955 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 306263002956 P loop; other site 306263002957 GTP binding site [chemical binding]; other site 306263002958 Signal peptide binding domain; Region: SRP_SPB; pfam02978 306263002959 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 306263002960 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 306263002961 active site 306263002962 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 306263002963 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 306263002964 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 306263002965 Putative zinc ribbon domain; Region: DUF164; pfam02591 306263002966 Uncharacterized conserved protein [Function unknown]; Region: COG0327 306263002967 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 306263002968 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 306263002969 dimer interface [polypeptide binding]; other site 306263002970 motif 1; other site 306263002971 active site 306263002972 motif 2; other site 306263002973 motif 3; other site 306263002974 Protein of unknown function (DUF3972); Region: DUF3972; pfam13118 306263002975 AIR carboxylase; Region: AIRC; smart01001 306263002976 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 306263002977 Peptidase family U32; Region: Peptidase_U32; pfam01136 306263002978 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 306263002979 glutamine synthetase, type I; Region: GlnA; TIGR00653 306263002980 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 306263002981 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 306263002982 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 306263002983 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 306263002984 active site 306263002985 NTP binding site [chemical binding]; other site 306263002986 metal binding triad [ion binding]; metal-binding site 306263002987 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 306263002988 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 306263002989 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 306263002990 putative active site [active] 306263002991 putative substrate binding site [chemical binding]; other site 306263002992 putative cosubstrate binding site; other site 306263002993 catalytic site [active] 306263002994 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 306263002995 NapD protein; Region: NapD; cl01163 306263002996 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 306263002997 FOG: WD40 repeat [General function prediction only]; Region: COG2319 306263002998 structural tetrad; other site 306263002999 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 306263003000 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 306263003001 4Fe-4S binding domain; Region: Fer4_5; pfam12801 306263003002 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 306263003003 4Fe-4S binding domain; Region: Fer4; cl02805 306263003004 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 306263003005 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 306263003006 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 306263003007 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 306263003008 molybdopterin cofactor binding site; other site 306263003009 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 306263003010 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 306263003011 molybdopterin cofactor binding site; other site 306263003012 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 306263003013 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 306263003014 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 306263003015 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 306263003016 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 306263003017 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 306263003018 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 306263003019 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 306263003020 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 306263003021 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 306263003022 DNA binding residues [nucleotide binding] 306263003023 polyphosphate kinase; Provisional; Region: PRK05443 306263003024 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 306263003025 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 306263003026 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 306263003027 putative domain interface [polypeptide binding]; other site 306263003028 putative active site [active] 306263003029 catalytic site [active] 306263003030 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 306263003031 putative domain interface [polypeptide binding]; other site 306263003032 putative active site [active] 306263003033 catalytic site [active] 306263003034 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 306263003035 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 306263003036 Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit [Inorganic ion transport and metabolism]; Region: NrfA; COG3303 306263003037 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 306263003038 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 306263003039 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 306263003040 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 306263003041 active site 306263003042 catalytic site [active] 306263003043 substrate binding site [chemical binding]; other site 306263003044 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 306263003045 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 306263003046 substrate binding site [chemical binding]; other site 306263003047 hexamer interface [polypeptide binding]; other site 306263003048 metal binding site [ion binding]; metal-binding site 306263003049 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 306263003050 Ion channel; Region: Ion_trans_2; pfam07885 306263003051 TrkA-N domain; Region: TrkA_N; pfam02254 306263003052 TrkA-C domain; Region: TrkA_C; pfam02080 306263003053 Protein of unknown function (DUF465); Region: DUF465; cl01070 306263003054 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 306263003055 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263003056 dimer interface [polypeptide binding]; other site 306263003057 putative CheW interface [polypeptide binding]; other site 306263003058 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 306263003059 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 306263003060 dimer interface [polypeptide binding]; other site 306263003061 ADP-ribose binding site [chemical binding]; other site 306263003062 active site 306263003063 nudix motif; other site 306263003064 metal binding site [ion binding]; metal-binding site 306263003065 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 306263003066 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 306263003067 ring oligomerisation interface [polypeptide binding]; other site 306263003068 ATP/Mg binding site [chemical binding]; other site 306263003069 stacking interactions; other site 306263003070 hinge regions; other site 306263003071 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 306263003072 oligomerisation interface [polypeptide binding]; other site 306263003073 mobile loop; other site 306263003074 roof hairpin; other site 306263003075 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 306263003076 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 306263003077 30S subunit binding site; other site 306263003078 3-methyladenine DNA glycosylase; Provisional; Region: PRK13913 306263003079 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 306263003080 minor groove reading motif; other site 306263003081 helix-hairpin-helix signature motif; other site 306263003082 active site 306263003083 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 306263003084 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 306263003085 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306263003086 ATP binding site [chemical binding]; other site 306263003087 putative Mg++ binding site [ion binding]; other site 306263003088 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306263003089 nucleotide binding region [chemical binding]; other site 306263003090 ATP-binding site [chemical binding]; other site 306263003091 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 306263003092 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 306263003093 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 306263003094 Peptidase family M23; Region: Peptidase_M23; pfam01551 306263003095 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 306263003096 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 306263003097 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306263003098 Lipopolysaccharide-assembly; Region: LptE; pfam04390 306263003099 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 306263003100 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 306263003101 HIGH motif; other site 306263003102 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 306263003103 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306263003104 active site 306263003105 KMSKS motif; other site 306263003106 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 306263003107 tRNA binding surface [nucleotide binding]; other site 306263003108 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 306263003109 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 306263003110 Protein export membrane protein; Region: SecD_SecF; pfam02355 306263003111 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 306263003112 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 306263003113 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 306263003114 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 306263003115 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 306263003116 active site 306263003117 catalytic triad [active] 306263003118 S-adenosylmethionine synthetase; Validated; Region: PRK05250 306263003119 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 306263003120 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 306263003121 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 306263003122 serine/threonine transporter SstT; Provisional; Region: PRK13628 306263003123 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 306263003124 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 306263003125 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 306263003126 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 306263003127 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 306263003128 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 306263003129 active site 306263003130 Zn binding site [ion binding]; other site 306263003131 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 306263003132 Part of AAA domain; Region: AAA_19; pfam13245 306263003133 Family description; Region: UvrD_C_2; pfam13538 306263003134 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04099 306263003135 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 306263003136 active site 306263003137 RNA-binding global regulator CsrA [Signal transduction mechanisms]; Region: CsrA; COG1551 306263003138 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 306263003139 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 306263003140 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 306263003141 SmpB-tmRNA interface; other site 306263003142 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 306263003143 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 306263003144 Uncharacterized conserved protein [Function unknown]; Region: COG2127 306263003145 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 306263003146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263003147 Walker A motif; other site 306263003148 ATP binding site [chemical binding]; other site 306263003149 Walker B motif; other site 306263003150 arginine finger; other site 306263003151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263003152 Walker A motif; other site 306263003153 ATP binding site [chemical binding]; other site 306263003154 Walker B motif; other site 306263003155 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 306263003156 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 306263003157 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 306263003158 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 306263003159 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 306263003160 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 306263003161 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 306263003162 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK03907 306263003163 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 306263003164 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 306263003165 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 306263003166 ferrochelatase; Reviewed; Region: hemH; PRK00035 306263003167 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 306263003168 C-terminal domain interface [polypeptide binding]; other site 306263003169 active site 306263003170 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 306263003171 active site 306263003172 N-terminal domain interface [polypeptide binding]; other site 306263003173 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 306263003174 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 306263003175 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 306263003176 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 306263003177 inhibitor-cofactor binding pocket; inhibition site 306263003178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263003179 catalytic residue [active] 306263003180 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 306263003181 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 306263003182 motif 1; other site 306263003183 active site 306263003184 motif 2; other site 306263003185 motif 3; other site 306263003186 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 306263003187 DHHA1 domain; Region: DHHA1; pfam02272 306263003188 Maf-like protein; Reviewed; Region: PRK04056 306263003189 Maf-like protein; Region: Maf; pfam02545 306263003190 putative active site [active] 306263003191 Transglycosylase; Region: Transgly; pfam00912 306263003192 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 306263003193 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 306263003194 TMAO/DMSO reductase; Reviewed; Region: PRK05363 306263003195 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 306263003196 Moco binding site; other site 306263003197 metal coordination site [ion binding]; other site 306263003198 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 306263003199 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 306263003200 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 306263003201 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 306263003202 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 306263003203 metal-binding site [ion binding] 306263003204 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 306263003205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263003206 motif II; other site 306263003207 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 306263003208 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 306263003209 hypothetical protein; Provisional; Region: PRK12378 306263003210 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 306263003211 active site 306263003212 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 306263003213 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 306263003214 Uncharacterized conserved protein [Function unknown]; Region: COG2966 306263003215 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 306263003216 Uncharacterized conserved protein [Function unknown]; Region: COG3610 306263003217 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 306263003218 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 306263003219 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 306263003220 active site 306263003221 HIGH motif; other site 306263003222 KMSK motif region; other site 306263003223 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 306263003224 tRNA binding surface [nucleotide binding]; other site 306263003225 anticodon binding site; other site 306263003226 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 306263003227 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 306263003228 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 306263003229 catalytic site [active] 306263003230 G-X2-G-X-G-K; other site 306263003231 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 306263003232 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 306263003233 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 306263003234 Walker A/P-loop; other site 306263003235 ATP binding site [chemical binding]; other site 306263003236 Q-loop/lid; other site 306263003237 ABC transporter signature motif; other site 306263003238 Walker B; other site 306263003239 D-loop; other site 306263003240 H-loop/switch region; other site 306263003241 elongation factor Ts; Provisional; Region: tsf; PRK09377 306263003242 UBA/TS-N domain; Region: UBA; pfam00627 306263003243 Elongation factor TS; Region: EF_TS; pfam00889 306263003244 Elongation factor TS; Region: EF_TS; pfam00889 306263003245 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 306263003246 rRNA interaction site [nucleotide binding]; other site 306263003247 S8 interaction site; other site 306263003248 putative laminin-1 binding site; other site 306263003249 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 306263003250 Cytochrome c; Region: Cytochrom_C; pfam00034 306263003251 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 306263003252 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 306263003253 Qi binding site; other site 306263003254 intrachain domain interface; other site 306263003255 interchain domain interface [polypeptide binding]; other site 306263003256 heme bH binding site [chemical binding]; other site 306263003257 heme bL binding site [chemical binding]; other site 306263003258 Qo binding site; other site 306263003259 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 306263003260 interchain domain interface [polypeptide binding]; other site 306263003261 intrachain domain interface; other site 306263003262 Qi binding site; other site 306263003263 Qo binding site; other site 306263003264 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 306263003265 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 306263003266 iron-sulfur cluster [ion binding]; other site 306263003267 [2Fe-2S] cluster binding site [ion binding]; other site 306263003268 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 306263003269 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 306263003270 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 306263003271 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 306263003272 Lumazine binding domain; Region: Lum_binding; pfam00677 306263003273 Lumazine binding domain; Region: Lum_binding; pfam00677 306263003274 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 306263003275 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 306263003276 PspC domain; Region: PspC; cl00864 306263003277 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 306263003278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 306263003279 dimer interface [polypeptide binding]; other site 306263003280 phosphorylation site [posttranslational modification] 306263003281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263003282 ATP binding site [chemical binding]; other site 306263003283 Mg2+ binding site [ion binding]; other site 306263003284 G-X-G motif; other site 306263003285 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 306263003286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263003287 active site 306263003288 phosphorylation site [posttranslational modification] 306263003289 intermolecular recognition site; other site 306263003290 dimerization interface [polypeptide binding]; other site 306263003291 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 306263003292 DNA binding site [nucleotide binding] 306263003293 Hemerythrin; Region: Hemerythrin; cd12107 306263003294 hypothetical protein; Provisional; Region: PRK04860 306263003295 Hemerythrin; Region: Hemerythrin; cd12107 306263003296 Fe binding site [ion binding]; other site 306263003297 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 306263003298 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 306263003299 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 306263003300 Cytochrome c; Region: Cytochrom_C; cl11414 306263003301 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 306263003302 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 306263003303 putative ligand binding site [chemical binding]; other site 306263003304 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 306263003305 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 306263003306 putative ligand binding site [chemical binding]; other site 306263003307 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 306263003308 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 306263003309 TM-ABC transporter signature motif; other site 306263003310 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 306263003311 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 306263003312 TM-ABC transporter signature motif; other site 306263003313 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 306263003314 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 306263003315 Walker A/P-loop; other site 306263003316 ATP binding site [chemical binding]; other site 306263003317 Q-loop/lid; other site 306263003318 ABC transporter signature motif; other site 306263003319 Walker B; other site 306263003320 D-loop; other site 306263003321 H-loop/switch region; other site 306263003322 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 306263003323 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 306263003324 Walker A/P-loop; other site 306263003325 ATP binding site [chemical binding]; other site 306263003326 Q-loop/lid; other site 306263003327 ABC transporter signature motif; other site 306263003328 Walker B; other site 306263003329 D-loop; other site 306263003330 H-loop/switch region; other site 306263003331 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 306263003332 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 306263003333 GTP-binding protein LepA; Provisional; Region: PRK05433 306263003334 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 306263003335 G1 box; other site 306263003336 putative GEF interaction site [polypeptide binding]; other site 306263003337 GTP/Mg2+ binding site [chemical binding]; other site 306263003338 Switch I region; other site 306263003339 G2 box; other site 306263003340 G3 box; other site 306263003341 Switch II region; other site 306263003342 G4 box; other site 306263003343 G5 box; other site 306263003344 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 306263003345 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 306263003346 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 306263003347 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 306263003348 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 306263003349 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 306263003350 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 306263003351 active site 306263003352 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 306263003353 thiamine phosphate binding site [chemical binding]; other site 306263003354 active site 306263003355 pyrophosphate binding site [ion binding]; other site 306263003356 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 306263003357 substrate binding site [chemical binding]; other site 306263003358 multimerization interface [polypeptide binding]; other site 306263003359 ATP binding site [chemical binding]; other site 306263003360 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 306263003361 substrate binding site [chemical binding]; other site 306263003362 dimer interface [polypeptide binding]; other site 306263003363 ATP binding site [chemical binding]; other site 306263003364 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 306263003365 Low molecular weight phosphatase family; Region: LMWPc; cd00115 306263003366 active site 306263003367 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 306263003368 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 306263003369 dimerization interface [polypeptide binding]; other site 306263003370 active site 306263003371 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 306263003372 dimer interface [polypeptide binding]; other site 306263003373 active site 306263003374 Schiff base residues; other site 306263003375 Protein of unknown function (DUF2603); Region: DUF2603; pfam10788 306263003376 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 306263003377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263003378 FeS/SAM binding site; other site 306263003379 HemN C-terminal domain; Region: HemN_C; pfam06969 306263003380 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 306263003381 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 306263003382 Cysteine-rich domain; Region: CCG; pfam02754 306263003383 Cysteine-rich domain; Region: CCG; pfam02754 306263003384 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 306263003385 alanine racemase; Reviewed; Region: alr; PRK00053 306263003386 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306263003387 catalytic residue [active] 306263003388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 306263003389 Protein of unknown function (DUF461); Region: DUF461; pfam04314 306263003390 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 306263003391 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 306263003392 Cu(I) binding site [ion binding]; other site 306263003393 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 306263003394 FtsX-like permease family; Region: FtsX; pfam02687 306263003395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3018 306263003396 DNA gyrase subunit A; Validated; Region: PRK05560 306263003397 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 306263003398 CAP-like domain; other site 306263003399 active site 306263003400 primary dimer interface [polypeptide binding]; other site 306263003401 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306263003402 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306263003403 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306263003404 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306263003405 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 306263003406 comF family protein; Region: comF; TIGR00201 306263003407 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306263003408 active site 306263003409 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 306263003410 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 306263003411 transmembrane helices; other site 306263003412 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 306263003413 thiamine phosphate binding site [chemical binding]; other site 306263003414 active site 306263003415 pyrophosphate binding site [ion binding]; other site 306263003416 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 306263003417 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263003418 FeS/SAM binding site; other site 306263003419 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 306263003420 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 306263003421 ThiS interaction site; other site 306263003422 putative active site [active] 306263003423 tetramer interface [polypeptide binding]; other site 306263003424 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 306263003425 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 306263003426 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 306263003427 putative ATP binding site [chemical binding]; other site 306263003428 putative substrate interface [chemical binding]; other site 306263003429 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 306263003430 thiS-thiF/thiG interaction site; other site 306263003431 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 306263003432 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 306263003433 metal binding site [ion binding]; metal-binding site 306263003434 dimer interface [polypeptide binding]; other site 306263003435 LysE type translocator; Region: LysE; cl00565 306263003436 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 306263003437 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 306263003438 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 306263003439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306263003440 Walker A/P-loop; other site 306263003441 ATP binding site [chemical binding]; other site 306263003442 Q-loop/lid; other site 306263003443 ABC transporter signature motif; other site 306263003444 Walker B; other site 306263003445 D-loop; other site 306263003446 H-loop/switch region; other site 306263003447 Smr domain; Region: Smr; pfam01713 306263003448 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 306263003449 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 306263003450 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 306263003451 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 306263003452 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 306263003453 Predicted amidohydrolase [General function prediction only]; Region: COG0388 306263003454 active site 306263003455 catalytic triad [active] 306263003456 dimer interface [polypeptide binding]; other site 306263003457 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 306263003458 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 306263003459 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 306263003460 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 306263003461 active site 306263003462 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 306263003463 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 306263003464 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 306263003465 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 306263003466 active site 306263003467 HIGH motif; other site 306263003468 nucleotide binding site [chemical binding]; other site 306263003469 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 306263003470 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 306263003471 active site 306263003472 KMSKS motif; other site 306263003473 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 306263003474 tRNA binding surface [nucleotide binding]; other site 306263003475 anticodon binding site; other site 306263003476 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 306263003477 Competence-damaged protein; Region: CinA; pfam02464 306263003478 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 306263003479 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 306263003480 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 306263003481 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 306263003482 catalytic residues [active] 306263003483 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 306263003484 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 306263003485 Walker A/P-loop; other site 306263003486 ATP binding site [chemical binding]; other site 306263003487 Q-loop/lid; other site 306263003488 ABC transporter signature motif; other site 306263003489 Walker B; other site 306263003490 D-loop; other site 306263003491 H-loop/switch region; other site 306263003492 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 306263003493 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 306263003494 FtsX-like permease family; Region: FtsX; pfam02687 306263003495 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 306263003496 FtsX-like permease family; Region: FtsX; pfam02687 306263003497 Predicted membrane protein [Function unknown]; Region: COG4393 306263003498 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 306263003499 Uncharacterized conserved protein [Function unknown]; Region: COG3350 306263003500 Fe2+ transport protein; Region: Iron_transport; pfam10634 306263003501 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 306263003502 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 306263003503 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 306263003504 homodimer interface [polypeptide binding]; other site 306263003505 substrate-cofactor binding pocket; other site 306263003506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263003507 catalytic residue [active] 306263003508 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 306263003509 MraW methylase family; Region: Methyltransf_5; cl17771 306263003510 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 306263003511 hypothetical protein; Provisional; Region: PRK05834 306263003512 SurA N-terminal domain; Region: SurA_N_3; cl07813 306263003513 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 306263003514 cell division protein FtsA; Region: ftsA; TIGR01174 306263003515 Cell division protein FtsA; Region: FtsA; smart00842 306263003516 Cell division protein FtsA; Region: FtsA; pfam14450 306263003517 cell division protein FtsZ; Validated; Region: PRK09330 306263003518 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 306263003519 nucleotide binding site [chemical binding]; other site 306263003520 SulA interaction site; other site 306263003521 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 306263003522 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 306263003523 active site 306263003524 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 306263003525 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 306263003526 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 306263003527 primosome assembly protein PriA; Validated; Region: PRK05580 306263003528 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306263003529 ATP binding site [chemical binding]; other site 306263003530 putative Mg++ binding site [ion binding]; other site 306263003531 helicase superfamily c-terminal domain; Region: HELICc; smart00490 306263003532 ATP-binding site [chemical binding]; other site 306263003533 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 306263003534 excinuclease ABC subunit B; Provisional; Region: PRK05298 306263003535 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306263003536 ATP binding site [chemical binding]; other site 306263003537 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 306263003538 nucleotide binding region [chemical binding]; other site 306263003539 ATP-binding site [chemical binding]; other site 306263003540 Ultra-violet resistance protein B; Region: UvrB; pfam12344 306263003541 UvrB/uvrC motif; Region: UVR; pfam02151 306263003542 elongation factor P; Validated; Region: PRK00529 306263003543 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 306263003544 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 306263003545 RNA binding site [nucleotide binding]; other site 306263003546 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 306263003547 RNA binding site [nucleotide binding]; other site 306263003548 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 306263003549 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 306263003550 ligand binding site [chemical binding]; other site 306263003551 NAD binding site [chemical binding]; other site 306263003552 dimerization interface [polypeptide binding]; other site 306263003553 catalytic site [active] 306263003554 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 306263003555 putative L-serine binding site [chemical binding]; other site 306263003556 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 306263003557 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 306263003558 RNA binding site [nucleotide binding]; other site 306263003559 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 306263003560 RNA binding site [nucleotide binding]; other site 306263003561 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 306263003562 RNA binding site [nucleotide binding]; other site 306263003563 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 306263003564 RNA binding site [nucleotide binding]; other site 306263003565 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 306263003566 RNA binding site [nucleotide binding]; other site 306263003567 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 306263003568 RNA binding site [nucleotide binding]; other site 306263003569 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 306263003570 LytB protein; Region: LYTB; pfam02401 306263003571 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 306263003572 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 306263003573 hinge; other site 306263003574 active site 306263003575 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 306263003576 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 306263003577 putative tRNA-binding site [nucleotide binding]; other site 306263003578 B3/4 domain; Region: B3_4; pfam03483 306263003579 tRNA synthetase B5 domain; Region: B5; pfam03484 306263003580 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 306263003581 dimer interface [polypeptide binding]; other site 306263003582 motif 1; other site 306263003583 motif 3; other site 306263003584 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 306263003585 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 306263003586 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 306263003587 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 306263003588 dimer interface [polypeptide binding]; other site 306263003589 motif 1; other site 306263003590 active site 306263003591 motif 2; other site 306263003592 motif 3; other site 306263003593 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 306263003594 nucleotide binding site/active site [active] 306263003595 HIT family signature motif; other site 306263003596 catalytic residue [active] 306263003597 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 306263003598 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 306263003599 active site 306263003600 substrate-binding site [chemical binding]; other site 306263003601 metal-binding site [ion binding] 306263003602 ATP binding site [chemical binding]; other site 306263003603 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 306263003604 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 306263003605 active site 306263003606 catalytic residues [active] 306263003607 metal binding site [ion binding]; metal-binding site 306263003608 homodimer binding site [polypeptide binding]; other site 306263003609 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 306263003610 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 306263003611 carboxyltransferase (CT) interaction site; other site 306263003612 biotinylation site [posttranslational modification]; other site 306263003613 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 306263003614 putative substrate binding site 1 [chemical binding]; other site 306263003615 Na binding site 1 [ion binding]; other site 306263003616 putative substrate binding site 2 [chemical binding]; other site 306263003617 Na2 binding site [ion binding]; other site 306263003618 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 306263003619 Na2 binding site [ion binding]; other site 306263003620 putative substrate binding site 1 [chemical binding]; other site 306263003621 Na binding site 1 [ion binding]; other site 306263003622 putative substrate binding site 2 [chemical binding]; other site 306263003623 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 306263003624 Na2 binding site [ion binding]; other site 306263003625 putative substrate binding site 1 [chemical binding]; other site 306263003626 Na binding site 1 [ion binding]; other site 306263003627 putative substrate binding site 2 [chemical binding]; other site 306263003628 F0F1 ATP synthase subunit C; Validated; Region: PRK08482 306263003629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 306263003630 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 306263003631 putative active site [active] 306263003632 heme pocket [chemical binding]; other site 306263003633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 306263003634 putative active site [active] 306263003635 heme pocket [chemical binding]; other site 306263003636 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263003637 dimer interface [polypeptide binding]; other site 306263003638 putative CheW interface [polypeptide binding]; other site 306263003639 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 306263003640 dihydroorotase; Provisional; Region: PRK08417 306263003641 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 306263003642 active site 306263003643 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 306263003644 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 306263003645 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 306263003646 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 306263003647 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 306263003648 GatB domain; Region: GatB_Yqey; smart00845 306263003649 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 306263003650 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 306263003651 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 306263003652 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 306263003653 DNA repair protein RadA; Provisional; Region: PRK11823 306263003654 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 306263003655 Walker A motif; other site 306263003656 ATP binding site [chemical binding]; other site 306263003657 Walker B motif; other site 306263003658 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 306263003659 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 306263003660 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 306263003661 P loop; other site 306263003662 GTP binding site [chemical binding]; other site 306263003663 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 306263003664 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 306263003665 catalytic residues [active] 306263003666 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 306263003667 phosphodiesterase; Provisional; Region: PRK12704 306263003668 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 306263003669 KH domain; Region: KH_1; pfam00013 306263003670 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 306263003671 Zn2+ binding site [ion binding]; other site 306263003672 Mg2+ binding site [ion binding]; other site 306263003673 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 306263003674 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 306263003675 Competence protein; Region: Competence; pfam03772 306263003676 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 306263003677 FAD binding domain; Region: FAD_binding_4; pfam01565 306263003678 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 306263003679 putative peptidase; Provisional; Region: PRK11649 306263003680 Peptidase family M23; Region: Peptidase_M23; pfam01551 306263003681 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 306263003682 MgtE intracellular N domain; Region: MgtE_N; pfam03448 306263003683 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 306263003684 Divalent cation transporter; Region: MgtE; pfam01769 306263003685 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 306263003686 dimer interface [polypeptide binding]; other site 306263003687 catalytic triad [active] 306263003688 peroxidatic and resolving cysteines [active] 306263003689 replicative DNA helicase; Provisional; Region: PRK08506 306263003690 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 306263003691 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 306263003692 Walker A motif; other site 306263003693 ATP binding site [chemical binding]; other site 306263003694 Walker B motif; other site 306263003695 DNA binding loops [nucleotide binding] 306263003696 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 306263003697 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 306263003698 dimer interface [polypeptide binding]; other site 306263003699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263003700 catalytic residue [active] 306263003701 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 306263003702 IHF - DNA interface [nucleotide binding]; other site 306263003703 IHF dimer interface [polypeptide binding]; other site 306263003704 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 306263003705 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 306263003706 putative active site [active] 306263003707 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 306263003708 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 306263003709 active site 306263003710 flagellin modification protein A; Provisional; Region: PRK09186 306263003711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 306263003712 NAD(P) binding site [chemical binding]; other site 306263003713 active site 306263003714 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 306263003715 ligand binding site; other site 306263003716 tetramer interface; other site 306263003717 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 306263003718 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 306263003719 FOG: CBS domain [General function prediction only]; Region: COG0517 306263003720 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 306263003721 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 306263003722 Substrate binding site; other site 306263003723 metal-binding site 306263003724 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 306263003725 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 306263003726 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651 306263003727 putative active site [active] 306263003728 putative substrate binding site [chemical binding]; other site 306263003729 putative cosubstrate binding site; other site 306263003730 catalytic site [active] 306263003731 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 306263003732 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 306263003733 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 306263003734 active site 306263003735 homodimer interface [polypeptide binding]; other site 306263003736 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 306263003737 NeuB family; Region: NeuB; pfam03102 306263003738 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 306263003739 NeuB binding interface [polypeptide binding]; other site 306263003740 putative substrate binding site [chemical binding]; other site 306263003741 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 306263003742 active site 306263003743 substrate binding site [chemical binding]; other site 306263003744 cosubstrate binding site; other site 306263003745 catalytic site [active] 306263003746 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 306263003747 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 306263003748 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 306263003749 NAD binding site [chemical binding]; other site 306263003750 substrate binding site [chemical binding]; other site 306263003751 active site 306263003752 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 306263003753 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 306263003754 active site 306263003755 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 306263003756 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 306263003757 active site 306263003758 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 306263003759 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 306263003760 active site 306263003761 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 306263003762 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 306263003763 active site 306263003764 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 306263003765 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 306263003766 active site 306263003767 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 306263003768 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 306263003769 putative metal binding site; other site 306263003770 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 306263003771 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 306263003772 Substrate binding site; other site 306263003773 metal-binding site 306263003774 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 306263003775 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 306263003776 putative acyl-acceptor binding pocket; other site 306263003777 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 306263003778 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 306263003779 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 306263003780 putative active site [active] 306263003781 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 306263003782 active site 306263003783 catalytic site [active] 306263003784 substrate binding site [chemical binding]; other site 306263003785 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 306263003786 UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179 306263003787 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 306263003788 NAD binding site [chemical binding]; other site 306263003789 homodimer interface [polypeptide binding]; other site 306263003790 active site 306263003791 substrate binding site [chemical binding]; other site 306263003792 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 306263003793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306263003794 Walker A/P-loop; other site 306263003795 ATP binding site [chemical binding]; other site 306263003796 Q-loop/lid; other site 306263003797 ABC transporter signature motif; other site 306263003798 Walker B; other site 306263003799 D-loop; other site 306263003800 H-loop/switch region; other site 306263003801 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 306263003802 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 306263003803 putative ADP-binding pocket [chemical binding]; other site 306263003804 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 306263003805 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 306263003806 putative ADP-binding pocket [chemical binding]; other site 306263003807 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 306263003808 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 306263003809 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 306263003810 putative ADP-binding pocket [chemical binding]; other site 306263003811 Bacterial sugar transferase; Region: Bac_transf; pfam02397 306263003812 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 306263003813 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 306263003814 putative trimer interface [polypeptide binding]; other site 306263003815 putative CoA binding site [chemical binding]; other site 306263003816 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 306263003817 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 306263003818 inhibitor-cofactor binding pocket; inhibition site 306263003819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263003820 catalytic residue [active] 306263003821 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 306263003822 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 306263003823 NAD(P) binding site [chemical binding]; other site 306263003824 homodimer interface [polypeptide binding]; other site 306263003825 substrate binding site [chemical binding]; other site 306263003826 active site 306263003827 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 306263003828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263003829 active site 306263003830 phosphorylation site [posttranslational modification] 306263003831 intermolecular recognition site; other site 306263003832 dimerization interface [polypeptide binding]; other site 306263003833 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 306263003834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263003835 S-adenosylmethionine binding site [chemical binding]; other site 306263003836 FtsH Extracellular; Region: FtsH_ext; pfam06480 306263003837 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 306263003838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263003839 Walker A motif; other site 306263003840 ATP binding site [chemical binding]; other site 306263003841 Walker B motif; other site 306263003842 arginine finger; other site 306263003843 Peptidase family M41; Region: Peptidase_M41; pfam01434 306263003844 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 306263003845 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 306263003846 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 306263003847 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 306263003848 DNA polymerase IV; Reviewed; Region: PRK03103 306263003849 Y-family of DNA polymerases; Region: PolY; cl12025 306263003850 active site 306263003851 DNA binding site [nucleotide binding] 306263003852 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 306263003853 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 306263003854 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 306263003855 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306263003856 active site 306263003857 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 306263003858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263003859 Walker A motif; other site 306263003860 ATP binding site [chemical binding]; other site 306263003861 Walker B motif; other site 306263003862 arginine finger; other site 306263003863 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 306263003864 Domain of unknown function DUF20; Region: UPF0118; pfam01594 306263003865 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 306263003866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263003867 Major Facilitator Superfamily; Region: MFS_1; pfam07690 306263003868 putative substrate translocation pore; other site 306263003869 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 306263003870 active site 306263003871 dimerization interface [polypeptide binding]; other site 306263003872 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 306263003873 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 306263003874 VacJ like lipoprotein; Region: VacJ; cl01073 306263003875 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 306263003876 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 306263003877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306263003878 Walker A/P-loop; other site 306263003879 ATP binding site [chemical binding]; other site 306263003880 ABC transporter; Region: ABC_tran; pfam00005 306263003881 Q-loop/lid; other site 306263003882 ABC transporter signature motif; other site 306263003883 Walker B; other site 306263003884 D-loop; other site 306263003885 H-loop/switch region; other site 306263003886 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 306263003887 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 306263003888 selenocysteine synthase; Provisional; Region: PRK04311 306263003889 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 306263003890 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 306263003891 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 306263003892 G1 box; other site 306263003893 putative GEF interaction site [polypeptide binding]; other site 306263003894 GTP/Mg2+ binding site [chemical binding]; other site 306263003895 Switch I region; other site 306263003896 G2 box; other site 306263003897 G3 box; other site 306263003898 Switch II region; other site 306263003899 G4 box; other site 306263003900 G5 box; other site 306263003901 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 306263003902 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 306263003903 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 306263003904 glutamate dehydrogenase; Provisional; Region: PRK09414 306263003905 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 306263003906 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 306263003907 NAD(P) binding pocket [chemical binding]; other site 306263003908 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 306263003909 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 306263003910 Malic enzyme, N-terminal domain; Region: malic; pfam00390 306263003911 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 306263003912 putative NAD(P) binding site [chemical binding]; other site 306263003913 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 306263003914 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 306263003915 active site 306263003916 HIGH motif; other site 306263003917 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 306263003918 active site 306263003919 KMSKS motif; other site 306263003920 SurA N-terminal domain; Region: SurA_N; pfam09312 306263003921 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 306263003922 biotin carboxylase; Validated; Region: PRK08462 306263003923 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 306263003924 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 306263003925 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 306263003926 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 306263003927 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 306263003928 carboxyltransferase (CT) interaction site; other site 306263003929 biotinylation site [posttranslational modification]; other site 306263003930 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 306263003931 trimer interface [polypeptide binding]; other site 306263003932 active site 306263003933 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 306263003934 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 306263003935 NAD(P) binding site [chemical binding]; other site 306263003936 homodimer interface [polypeptide binding]; other site 306263003937 substrate binding site [chemical binding]; other site 306263003938 active site 306263003939 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 306263003940 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 306263003941 inhibitor-cofactor binding pocket; inhibition site 306263003942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263003943 catalytic residue [active] 306263003944 M28 Zn-Peptidases; Region: M28_like_3; cd05644 306263003945 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 306263003946 active site 306263003947 metal binding site [ion binding]; metal-binding site 306263003948 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 306263003949 Methyltransferase domain; Region: Methyltransf_23; pfam13489 306263003950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263003951 S-adenosylmethionine binding site [chemical binding]; other site 306263003952 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 306263003953 Acid Phosphatase; Region: Acid_PPase; cl17256 306263003954 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12880 306263003955 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 306263003956 dimer interface [polypeptide binding]; other site 306263003957 active site 306263003958 CoA binding pocket [chemical binding]; other site 306263003959 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 306263003960 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 306263003961 potential frameshift: common BLAST hit: gi|218562909|ref|YP_002344688.1| N-acetyltransferase 306263003962 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 306263003963 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 306263003964 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 306263003965 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 306263003966 acyl-activating enzyme (AAE) consensus motif; other site 306263003967 AMP binding site [chemical binding]; other site 306263003968 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 306263003969 active site 306263003970 cosubstrate binding site; other site 306263003971 substrate binding site [chemical binding]; other site 306263003972 catalytic site [active] 306263003973 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 306263003974 active site 306263003975 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 306263003976 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 306263003977 ligand binding site; other site 306263003978 tetramer interface; other site 306263003979 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 306263003980 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 306263003981 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_1; cd08821 306263003982 putative active site [active] 306263003983 putative substrate binding site [chemical binding]; other site 306263003984 putative cosubstrate binding site; other site 306263003985 catalytic site [active] 306263003986 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 306263003987 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 306263003988 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 306263003989 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 306263003990 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 306263003991 substrate binding site [chemical binding]; other site 306263003992 glutamase interaction surface [polypeptide binding]; other site 306263003993 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 306263003994 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 306263003995 putative active site [active] 306263003996 oxyanion strand; other site 306263003997 catalytic triad [active] 306263003998 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 306263003999 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 306263004000 Ligand Binding Site [chemical binding]; other site 306263004001 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 306263004002 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 306263004003 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 306263004004 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 306263004005 HAMP domain; Region: HAMP; pfam00672 306263004006 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263004007 dimer interface [polypeptide binding]; other site 306263004008 putative CheW interface [polypeptide binding]; other site 306263004009 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 306263004010 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 306263004011 dimer interface [polypeptide binding]; other site 306263004012 decamer (pentamer of dimers) interface [polypeptide binding]; other site 306263004013 catalytic triad [active] 306263004014 peroxidatic and resolving cysteines [active] 306263004015 Ferredoxin [Energy production and conversion]; Region: COG1146 306263004016 4Fe-4S binding domain; Region: Fer4; cl02805 306263004017 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 306263004018 active site 306263004019 multimer interface [polypeptide binding]; other site 306263004020 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 306263004021 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 306263004022 putative phosphate acyltransferase; Provisional; Region: PRK05331 306263004023 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 306263004024 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 306263004025 dimer interface [polypeptide binding]; other site 306263004026 active site 306263004027 CoA binding pocket [chemical binding]; other site 306263004028 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 306263004029 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 306263004030 ligand binding site [chemical binding]; other site 306263004031 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 306263004032 flagellar motor protein MotA; Validated; Region: PRK08456 306263004033 DNA polymerase I; Provisional; Region: PRK05755 306263004034 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 306263004035 active site 306263004036 metal binding site 1 [ion binding]; metal-binding site 306263004037 putative 5' ssDNA interaction site; other site 306263004038 metal binding site 3; metal-binding site 306263004039 metal binding site 2 [ion binding]; metal-binding site 306263004040 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 306263004041 putative DNA binding site [nucleotide binding]; other site 306263004042 putative metal binding site [ion binding]; other site 306263004043 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 306263004044 active site 306263004045 catalytic site [active] 306263004046 substrate binding site [chemical binding]; other site 306263004047 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 306263004048 active site 306263004049 DNA binding site [nucleotide binding] 306263004050 catalytic site [active] 306263004051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 306263004052 metabolite-proton symporter; Region: 2A0106; TIGR00883 306263004053 putative substrate translocation pore; other site 306263004054 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 306263004055 active site 306263004056 Predicted membrane protein [Function unknown]; Region: COG1238 306263004057 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 306263004058 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 306263004059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263004060 catalytic residue [active] 306263004061 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 306263004062 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 306263004063 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 306263004064 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 306263004065 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 306263004066 carbon starvation protein A; Provisional; Region: PRK15015 306263004067 Carbon starvation protein CstA; Region: CstA; pfam02554 306263004068 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 306263004069 Protein of unknown function (DUF466); Region: DUF466; pfam04328 306263004070 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 306263004071 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306263004072 catalytic residue [active] 306263004073 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 306263004074 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 306263004075 generic binding surface I; other site 306263004076 generic binding surface II; other site 306263004077 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 306263004078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263004079 S-adenosylmethionine binding site [chemical binding]; other site 306263004080 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 306263004081 metal binding site 2 [ion binding]; metal-binding site 306263004082 putative DNA binding helix; other site 306263004083 metal binding site 1 [ion binding]; metal-binding site 306263004084 structural Zn2+ binding site [ion binding]; other site 306263004085 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 306263004086 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 306263004087 TPP-binding site; other site 306263004088 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 306263004089 PYR/PP interface [polypeptide binding]; other site 306263004090 dimer interface [polypeptide binding]; other site 306263004091 TPP binding site [chemical binding]; other site 306263004092 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 306263004093 flagellar assembly protein H; Validated; Region: fliH; PRK06669 306263004094 Flagellar assembly protein FliH; Region: FliH; pfam02108 306263004095 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 306263004096 MgtE intracellular N domain; Region: MgtE_N; cl15244 306263004097 FliG C-terminal domain; Region: FliG_C; pfam01706 306263004098 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 306263004099 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 306263004100 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 306263004101 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 306263004102 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 306263004103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263004104 homodimer interface [polypeptide binding]; other site 306263004105 catalytic residue [active] 306263004106 Chorismate mutase type II; Region: CM_2; cl00693 306263004107 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 306263004108 Prephenate dehydratase; Region: PDT; pfam00800 306263004109 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 306263004110 putative L-Phe binding site [chemical binding]; other site 306263004111 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 306263004112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263004113 active site 306263004114 motif I; other site 306263004115 motif II; other site 306263004116 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 306263004117 diaminopimelate decarboxylase; Region: lysA; TIGR01048 306263004118 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 306263004119 active site 306263004120 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 306263004121 substrate binding site [chemical binding]; other site 306263004122 catalytic residues [active] 306263004123 dimer interface [polypeptide binding]; other site 306263004124 Predicted permeases [General function prediction only]; Region: COG0795 306263004125 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 306263004126 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 306263004127 putative active site [active] 306263004128 catalytic residue [active] 306263004129 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 306263004130 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 306263004131 5S rRNA interface [nucleotide binding]; other site 306263004132 CTC domain interface [polypeptide binding]; other site 306263004133 L16 interface [polypeptide binding]; other site 306263004134 Class I aldolases; Region: Aldolase_Class_I; cl17187 306263004135 transaldolase; Provisional; Region: PRK03903 306263004136 catalytic residue [active] 306263004137 phosphoserine phosphatase SerB; Region: serB; TIGR00338 306263004138 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 306263004139 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 306263004140 motif II; other site 306263004141 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 306263004142 putative CheA interaction surface; other site 306263004143 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 306263004144 putative binding surface; other site 306263004145 active site 306263004146 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 306263004147 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 306263004148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 306263004149 ATP binding site [chemical binding]; other site 306263004150 Mg2+ binding site [ion binding]; other site 306263004151 G-X-G motif; other site 306263004152 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 306263004153 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 306263004154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263004155 active site 306263004156 phosphorylation site [posttranslational modification] 306263004157 intermolecular recognition site; other site 306263004158 dimerization interface [polypeptide binding]; other site 306263004159 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 306263004160 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 306263004161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 306263004162 active site 306263004163 phosphorylation site [posttranslational modification] 306263004164 intermolecular recognition site; other site 306263004165 dimerization interface [polypeptide binding]; other site 306263004166 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 306263004167 putative active site [active] 306263004168 putative metal binding site [ion binding]; other site 306263004169 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 306263004170 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 306263004171 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 306263004172 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 306263004173 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 306263004174 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 306263004175 CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081 306263004176 putative catalytic site [active] 306263004177 CdtC interface [polypeptide binding]; other site 306263004178 heterotrimer interface [polypeptide binding]; other site 306263004179 CdtA interface [polypeptide binding]; other site 306263004180 putative metal binding site [ion binding]; other site 306263004181 putative phosphate binding site [ion binding]; other site 306263004182 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 306263004183 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 306263004184 putative sugar binding sites [chemical binding]; other site 306263004185 Q-X-W motif; other site 306263004186 peptidase T; Region: peptidase-T; TIGR01882 306263004187 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 306263004188 metal binding site [ion binding]; metal-binding site 306263004189 dimer interface [polypeptide binding]; other site 306263004190 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 306263004191 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 306263004192 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 306263004193 active site pocket [active] 306263004194 oxyanion hole [active] 306263004195 catalytic triad [active] 306263004196 active site nucleophile [active] 306263004197 Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588 306263004198 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 306263004199 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 306263004200 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 306263004201 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 306263004202 ATP binding site [chemical binding]; other site 306263004203 substrate interface [chemical binding]; other site 306263004204 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 306263004205 CAAX protease self-immunity; Region: Abi; pfam02517 306263004206 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 306263004207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263004208 S-adenosylmethionine binding site [chemical binding]; other site 306263004209 Protein of unknown function (DUF452); Region: DUF452; cl01062 306263004210 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 306263004211 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 306263004212 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306263004213 catalytic residue [active] 306263004214 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 306263004215 Sel1-like repeats; Region: SEL1; smart00671 306263004216 Sel1-like repeats; Region: SEL1; smart00671 306263004217 Sel1-like repeats; Region: SEL1; smart00671 306263004218 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 306263004219 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 306263004220 inhibitor-cofactor binding pocket; inhibition site 306263004221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263004222 catalytic residue [active] 306263004223 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 306263004224 AAA domain; Region: AAA_26; pfam13500 306263004225 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 306263004226 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 306263004227 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 306263004228 catalytic nucleophile [active] 306263004229 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 306263004230 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 306263004231 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 306263004232 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 306263004233 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 306263004234 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 306263004235 ATP-grasp domain; Region: ATP-grasp_4; cl17255 306263004236 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 306263004237 IMP binding site; other site 306263004238 dimer interface [polypeptide binding]; other site 306263004239 interdomain contacts; other site 306263004240 partial ornithine binding site; other site 306263004241 rod shape-determining protein MreC; Provisional; Region: PRK13922 306263004242 rod shape-determining protein MreC; Region: MreC; pfam04085 306263004243 rod shape-determining protein MreB; Provisional; Region: PRK13927 306263004244 MreB and similar proteins; Region: MreB_like; cd10225 306263004245 nucleotide binding site [chemical binding]; other site 306263004246 Mg binding site [ion binding]; other site 306263004247 putative protofilament interaction site [polypeptide binding]; other site 306263004248 RodZ interaction site [polypeptide binding]; other site 306263004249 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 306263004250 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 306263004251 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 306263004252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263004253 Walker A motif; other site 306263004254 ATP binding site [chemical binding]; other site 306263004255 Walker B motif; other site 306263004256 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 306263004257 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 306263004258 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 306263004259 active site 306263004260 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 306263004261 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 306263004262 Ligand Binding Site [chemical binding]; other site 306263004263 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 306263004264 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 306263004265 catalytic triad [active] 306263004266 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 306263004267 active site 1 [active] 306263004268 dimer interface [polypeptide binding]; other site 306263004269 hexamer interface [polypeptide binding]; other site 306263004270 active site 2 [active] 306263004271 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 306263004272 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 306263004273 homodimer interface [polypeptide binding]; other site 306263004274 substrate-cofactor binding pocket; other site 306263004275 catalytic residue [active] 306263004276 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 306263004277 SPFH domain / Band 7 family; Region: Band_7; pfam01145 306263004278 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 306263004279 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 306263004280 amidophosphoribosyltransferase; Provisional; Region: PRK08525 306263004281 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 306263004282 active site 306263004283 tetramer interface [polypeptide binding]; other site 306263004284 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306263004285 active site 306263004286 dihydrodipicolinate reductase; Provisional; Region: PRK00048 306263004287 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 306263004288 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 306263004289 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 306263004290 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 306263004291 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 306263004292 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 306263004293 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 306263004294 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 306263004295 catalytic residues [active] 306263004296 hypothetical protein; Reviewed; Region: PRK12497 306263004297 homoserine dehydrogenase; Provisional; Region: PRK06349 306263004298 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 306263004299 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 306263004300 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 306263004301 aspartate aminotransferase; Provisional; Region: PRK08636 306263004302 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 306263004303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 306263004304 homodimer interface [polypeptide binding]; other site 306263004305 catalytic residue [active] 306263004306 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 306263004307 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 306263004308 Predicted methyltransferases [General function prediction only]; Region: COG0313 306263004309 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 306263004310 putative SAM binding site [chemical binding]; other site 306263004311 putative homodimer interface [polypeptide binding]; other site 306263004312 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 306263004313 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 306263004314 RNA methyltransferase, RsmE family; Region: TIGR00046 306263004315 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 306263004316 active site 306263004317 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 306263004318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263004319 FeS/SAM binding site; other site 306263004320 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 306263004321 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263004322 FeS/SAM binding site; other site 306263004323 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 306263004324 prenyltransferase; Reviewed; Region: ubiA; PRK12874 306263004325 UbiA prenyltransferase family; Region: UbiA; pfam01040 306263004326 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 306263004327 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 306263004328 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 306263004329 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 306263004330 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 306263004331 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 306263004332 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 306263004333 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 306263004334 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713 306263004335 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 306263004336 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 306263004337 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 306263004338 4Fe-4S binding domain; Region: Fer4; pfam00037 306263004339 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 306263004340 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 306263004341 NADH dehydrogenase subunit G; Validated; Region: PRK08493 306263004342 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 306263004343 catalytic loop [active] 306263004344 iron binding site [ion binding]; other site 306263004345 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 306263004346 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 306263004347 NADH dehydrogenase subunit G; Validated; Region: PRK08493 306263004348 NADH dehydrogenase subunit D; Validated; Region: PRK06075 306263004349 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 306263004350 NADH dehydrogenase subunit C; Provisional; Region: PRK08491 306263004351 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 306263004352 NADH dehydrogenase subunit B; Validated; Region: PRK06411 306263004353 NADH dehydrogenase subunit A; Validated; Region: PRK08489 306263004354 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 306263004355 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 306263004356 Walker A/P-loop; other site 306263004357 ATP binding site [chemical binding]; other site 306263004358 Q-loop/lid; other site 306263004359 ABC transporter signature motif; other site 306263004360 Walker B; other site 306263004361 D-loop; other site 306263004362 H-loop/switch region; other site 306263004363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 306263004364 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 306263004365 Q-loop/lid; other site 306263004366 ABC transporter signature motif; other site 306263004367 Walker B; other site 306263004368 D-loop; other site 306263004369 H-loop/switch region; other site 306263004370 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 306263004371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263004372 dimer interface [polypeptide binding]; other site 306263004373 conserved gate region; other site 306263004374 putative PBP binding loops; other site 306263004375 ABC-ATPase subunit interface; other site 306263004376 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 306263004377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263004378 dimer interface [polypeptide binding]; other site 306263004379 conserved gate region; other site 306263004380 putative PBP binding loops; other site 306263004381 ABC-ATPase subunit interface; other site 306263004382 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 306263004383 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 306263004384 BCCT family transporter; Region: BCCT; pfam02028 306263004385 Uncharacterized conserved protein [Function unknown]; Region: COG1556 306263004386 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 306263004387 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 306263004388 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 306263004389 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 306263004390 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 306263004391 Cysteine-rich domain; Region: CCG; pfam02754 306263004392 Cysteine-rich domain; Region: CCG; pfam02754 306263004393 L-lactate permease; Region: Lactate_perm; cl00701 306263004394 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 306263004395 Glypican; Region: Glypican; pfam01153 306263004396 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 306263004397 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 306263004398 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 306263004399 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 306263004400 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 306263004401 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 306263004402 molybdopterin cofactor binding site [chemical binding]; other site 306263004403 substrate binding site [chemical binding]; other site 306263004404 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 306263004405 molybdopterin cofactor binding site; other site 306263004406 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 306263004407 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 306263004408 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 306263004409 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 306263004410 active site 306263004411 substrate binding site [chemical binding]; other site 306263004412 cosubstrate binding site; other site 306263004413 catalytic site [active] 306263004414 Uncharacterized conserved protein [Function unknown]; Region: COG0062 306263004415 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 306263004416 putative substrate binding site [chemical binding]; other site 306263004417 putative ATP binding site [chemical binding]; other site 306263004418 RmuC family; Region: RmuC; pfam02646 306263004419 Uncharacterized conserved protein [Function unknown]; Region: COG1432 306263004420 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 306263004421 putative metal binding site [ion binding]; other site 306263004422 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 306263004423 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 306263004424 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 306263004425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263004426 Walker A motif; other site 306263004427 ATP binding site [chemical binding]; other site 306263004428 Walker B motif; other site 306263004429 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 306263004430 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 306263004431 active site 306263004432 catalytic residues [active] 306263004433 metal binding site [ion binding]; metal-binding site 306263004434 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 306263004435 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 306263004436 metal binding site [ion binding]; metal-binding site 306263004437 active site 306263004438 I-site; other site 306263004439 Clp protease; Region: CLP_protease; pfam00574 306263004440 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 306263004441 oligomer interface [polypeptide binding]; other site 306263004442 active site residues [active] 306263004443 trigger factor; Provisional; Region: tig; PRK01490 306263004444 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 306263004445 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 306263004446 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 306263004447 homodecamer interface [polypeptide binding]; other site 306263004448 GTP cyclohydrolase I; Provisional; Region: PLN03044 306263004449 active site 306263004450 putative catalytic site residues [active] 306263004451 zinc binding site [ion binding]; other site 306263004452 GTP-CH-I/GFRP interaction surface; other site 306263004453 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 306263004454 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 306263004455 Walker A motif/ATP binding site; other site 306263004456 Walker B motif; other site 306263004457 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 306263004458 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 306263004459 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 306263004460 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 306263004461 catalytic residue [active] 306263004462 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 306263004463 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 306263004464 trimerization site [polypeptide binding]; other site 306263004465 active site 306263004466 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 306263004467 NifU-like domain; Region: NifU; cl00484 306263004468 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 306263004469 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 306263004470 Predicted membrane protein [Function unknown]; Region: COG2860 306263004471 UPF0126 domain; Region: UPF0126; pfam03458 306263004472 UPF0126 domain; Region: UPF0126; pfam03458 306263004473 ATP-grasp domain; Region: ATP-grasp_4; cl17255 306263004474 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 306263004475 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 306263004476 Tetramer interface [polypeptide binding]; other site 306263004477 active site 306263004478 FMN-binding site [chemical binding]; other site 306263004479 ribonuclease III; Reviewed; Region: rnc; PRK00102 306263004480 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 306263004481 dimerization interface [polypeptide binding]; other site 306263004482 active site 306263004483 metal binding site [ion binding]; metal-binding site 306263004484 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 306263004485 dsRNA binding site [nucleotide binding]; other site 306263004486 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 306263004487 RNA/DNA hybrid binding site [nucleotide binding]; other site 306263004488 active site 306263004489 Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have...; Region: ZZ; cl00295 306263004490 Zinc-binding sites [ion binding]; other site 306263004491 zinc cluster 1 [ion binding]; other site 306263004492 putative charged binding surface; other site 306263004493 putative hydrophobic binding surface; other site 306263004494 zinc cluster 2 [ion binding]; other site 306263004495 DNA primase; Validated; Region: dnaG; PRK05667 306263004496 CHC2 zinc finger; Region: zf-CHC2; pfam01807 306263004497 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 306263004498 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 306263004499 active site 306263004500 metal binding site [ion binding]; metal-binding site 306263004501 interdomain interaction site; other site 306263004502 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 306263004503 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 306263004504 Ligand Binding Site [chemical binding]; other site 306263004505 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 306263004506 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263004507 dimer interface [polypeptide binding]; other site 306263004508 putative CheW interface [polypeptide binding]; other site 306263004509 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 306263004510 Transglycosylase; Region: Transgly; pfam00912 306263004511 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 306263004512 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 306263004513 Bacterial Ig-like domain; Region: Big_5; pfam13205 306263004514 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 306263004515 MG2 domain; Region: A2M_N; pfam01835 306263004516 Alpha-2-macroglobulin family; Region: A2M; pfam00207 306263004517 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 306263004518 surface patch; other site 306263004519 thioester region; other site 306263004520 specificity defining residues; other site 306263004521 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 306263004522 Mechanosensitive ion channel; Region: MS_channel; pfam00924 306263004523 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 306263004524 active site clefts [active] 306263004525 zinc binding site [ion binding]; other site 306263004526 dimer interface [polypeptide binding]; other site 306263004527 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 306263004528 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 306263004529 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 306263004530 ribosome recycling factor; Reviewed; Region: frr; PRK00083 306263004531 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 306263004532 hinge region; other site 306263004533 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 306263004534 active site 306263004535 RDD family; Region: RDD; pfam06271 306263004536 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 306263004537 dimer interface [polypeptide binding]; other site 306263004538 putative radical transfer pathway; other site 306263004539 diiron center [ion binding]; other site 306263004540 tyrosyl radical; other site 306263004541 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 306263004542 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 306263004543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263004544 S-adenosylmethionine binding site [chemical binding]; other site 306263004545 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 306263004546 active site 306263004547 zinc binding site [ion binding]; other site 306263004548 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 306263004549 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 306263004550 G1 box; other site 306263004551 putative GEF interaction site [polypeptide binding]; other site 306263004552 GTP/Mg2+ binding site [chemical binding]; other site 306263004553 Switch I region; other site 306263004554 G2 box; other site 306263004555 G3 box; other site 306263004556 Switch II region; other site 306263004557 G4 box; other site 306263004558 G5 box; other site 306263004559 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 306263004560 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 306263004561 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 306263004562 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12812 306263004563 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 306263004564 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 306263004565 flagellar hook protein FlgE; Validated; Region: flgE; PRK05841 306263004566 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 306263004567 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 306263004568 HD domain; Region: HD_3; pfam13023 306263004569 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 306263004570 Fic/DOC family; Region: Fic; cl00960 306263004571 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 306263004572 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 306263004573 Walker A/P-loop; other site 306263004574 ATP binding site [chemical binding]; other site 306263004575 Q-loop/lid; other site 306263004576 ABC transporter signature motif; other site 306263004577 Walker B; other site 306263004578 D-loop; other site 306263004579 H-loop/switch region; other site 306263004580 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 306263004581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 306263004582 dimer interface [polypeptide binding]; other site 306263004583 conserved gate region; other site 306263004584 putative PBP binding loops; other site 306263004585 ABC-ATPase subunit interface; other site 306263004586 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 306263004587 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 306263004588 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 306263004589 heme-binding site [chemical binding]; other site 306263004590 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 306263004591 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 306263004592 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 306263004593 Walker A/P-loop; other site 306263004594 ATP binding site [chemical binding]; other site 306263004595 Q-loop/lid; other site 306263004596 ABC transporter signature motif; other site 306263004597 Walker B; other site 306263004598 D-loop; other site 306263004599 H-loop/switch region; other site 306263004600 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 306263004601 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 306263004602 Surface antigen; Region: Bac_surface_Ag; pfam01103 306263004603 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 306263004604 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 306263004605 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 306263004606 active site 306263004607 Zn binding site [ion binding]; other site 306263004608 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 306263004609 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 306263004610 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 306263004611 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 306263004612 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 306263004613 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 306263004614 Domain of unknown function (DUF814); Region: DUF814; pfam05670 306263004615 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 306263004616 GTP binding site; other site 306263004617 Predicted permease [General function prediction only]; Region: COG2056 306263004618 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 306263004619 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 306263004620 Cache domain; Region: Cache_1; pfam02743 306263004621 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 306263004622 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263004623 dimer interface [polypeptide binding]; other site 306263004624 putative CheW interface [polypeptide binding]; other site 306263004625 Cache domain; Region: Cache_1; pfam02743 306263004626 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 306263004627 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 306263004628 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 306263004629 dimer interface [polypeptide binding]; other site 306263004630 putative CheW interface [polypeptide binding]; other site 306263004631 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 306263004632 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 306263004633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263004634 Walker A motif; other site 306263004635 ATP binding site [chemical binding]; other site 306263004636 Walker B motif; other site 306263004637 arginine finger; other site 306263004638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 306263004639 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 306263004640 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 306263004641 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 306263004642 putative ligand binding site [chemical binding]; other site 306263004643 putative NAD binding site [chemical binding]; other site 306263004644 catalytic site [active] 306263004645 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 306263004646 hypothetical protein; Provisional; Region: PRK04081 306263004647 LysE type translocator; Region: LysE; cl00565 306263004648 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 306263004649 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 306263004650 4Fe-4S binding domain; Region: Fer4_5; pfam12801 306263004651 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 306263004652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 306263004653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 306263004654 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 306263004655 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 306263004656 HlyD family secretion protein; Region: HlyD_3; pfam13437 306263004657 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 306263004658 Protein export membrane protein; Region: SecD_SecF; cl14618 306263004659 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 306263004660 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 306263004661 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 306263004662 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 306263004663 FeS/SAM binding site; other site 306263004664 Methyltransferase domain; Region: Methyltransf_31; pfam13847 306263004665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 306263004666 S-adenosylmethionine binding site [chemical binding]; other site 306263004667 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 306263004668 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 306263004669 lipoprotein signal peptidase; Provisional; Region: PRK14787 306263004670 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 306263004671 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 306263004672 active site 306263004673 substrate binding site [chemical binding]; other site 306263004674 metal binding site [ion binding]; metal-binding site 306263004675 recombination factor protein RarA; Reviewed; Region: PRK13342 306263004676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 306263004677 Walker A motif; other site 306263004678 ATP binding site [chemical binding]; other site 306263004679 Walker B motif; other site 306263004680 arginine finger; other site 306263004681 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 306263004682 Domain of unknown function (DUF305); Region: DUF305; pfam03713 306263004683 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 306263004684 active site 306263004685 putative DNA-binding cleft [nucleotide binding]; other site 306263004686 dimer interface [polypeptide binding]; other site 306263004687 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 306263004688 Methyltransferase domain; Region: Methyltransf_26; pfam13659 306263004689 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 306263004690 DEAD-like helicases superfamily; Region: DEXDc; smart00487 306263004691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 306263004692 ATP binding site [chemical binding]; other site 306263004693 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 306263004694 putative Mg++ binding site [ion binding]; other site 306263004695 helicase superfamily c-terminal domain; Region: HELICc; smart00490 306263004696 multiple promoter invertase; Provisional; Region: mpi; PRK13413 306263004697 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 306263004698 catalytic residues [active] 306263004699 catalytic nucleophile [active] 306263004700 Presynaptic Site I dimer interface [polypeptide binding]; other site 306263004701 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 306263004702 Synaptic Flat tetramer interface [polypeptide binding]; other site 306263004703 Synaptic Site I dimer interface [polypeptide binding]; other site 306263004704 DNA binding site [nucleotide binding] 306263004705 ParA-like protein; Provisional; Region: PHA02518 306263004706 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 306263004707 P-loop; other site 306263004708 Magnesium ion binding site [ion binding]; other site 306263004709 Type IV secretory pathway, VirB3-like protein; Region: VirB3; pfam05101 306263004710 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 306263004711 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 306263004712 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 306263004713 Type IV secretion system proteins; Region: T4SS; pfam07996 306263004714 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 306263004715 BRO family, N-terminal domain; Region: Bro-N; smart01040 306263004716 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 306263004717 VirB8 protein; Region: VirB8; pfam04335 306263004718 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 306263004719 VirB7 interaction site; other site 306263004720 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 306263004721 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 306263004722 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 306263004723 Walker A motif; other site 306263004724 hexamer interface [polypeptide binding]; other site 306263004725 ATP binding site [chemical binding]; other site 306263004726 Walker B motif; other site 306263004727 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 306263004728 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 306263004729 Walker A motif; other site 306263004730 ATP binding site [chemical binding]; other site 306263004731 Walker B motif; other site 306263004732 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 306263004733 TrbM; Region: TrbM; pfam07424 306263004734 DNA topoisomerase III; Provisional; Region: PRK07726 306263004735 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 306263004736 active site 306263004737 putative interdomain interaction site [polypeptide binding]; other site 306263004738 putative metal-binding site [ion binding]; other site 306263004739 putative nucleotide binding site [chemical binding]; other site 306263004740 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 306263004741 domain I; other site 306263004742 DNA binding groove [nucleotide binding] 306263004743 phosphate binding site [ion binding]; other site 306263004744 domain II; other site 306263004745 domain III; other site 306263004746 nucleotide binding site [chemical binding]; other site 306263004747 catalytic site [active] 306263004748 domain IV; other site 306263004749 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 306263004750 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 306263004751 dimer interface [polypeptide binding]; other site 306263004752 ssDNA binding site [nucleotide binding]; other site 306263004753 tetramer (dimer of dimers) interface [polypeptide binding]; other site 306263004754 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 306263004755 multiple promoter invertase; Provisional; Region: mpi; PRK13413 306263004756 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 306263004757 catalytic residues [active] 306263004758 catalytic nucleophile [active] 306263004759 Presynaptic Site I dimer interface [polypeptide binding]; other site 306263004760 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 306263004761 Synaptic Flat tetramer interface [polypeptide binding]; other site 306263004762 Synaptic Site I dimer interface [polypeptide binding]; other site 306263004763 DNA binding site [nucleotide binding] 306263004764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 306263004765 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 306263004766 active site 306263004767 metal binding site [ion binding]; metal-binding site 306263004768 interdomain interaction site; other site 306263004769 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 306263004770 putative active site [active] 306263004771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 306263004772 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 306263004773 active site 306263004774 metal binding site [ion binding]; metal-binding site 306263004775 interdomain interaction site; other site