-- dump date 20140619_022256 -- class Genbank::misc_feature -- table misc_feature_note -- id note 452471000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 452471000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 452471000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471000004 Walker A motif; other site 452471000005 ATP binding site [chemical binding]; other site 452471000006 Walker B motif; other site 452471000007 arginine finger; other site 452471000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 452471000009 DnaA box-binding interface [nucleotide binding]; other site 452471000010 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 452471000011 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 452471000012 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 452471000013 TRAM domain; Region: TRAM; cl01282 452471000014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452471000015 S-adenosylmethionine binding site [chemical binding]; other site 452471000016 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 452471000017 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452471000018 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 452471000019 Predicted permeases [General function prediction only]; Region: COG0795 452471000020 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 452471000021 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 452471000022 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 452471000023 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 452471000024 16S/18S rRNA binding site [nucleotide binding]; other site 452471000025 S13e-L30e interaction site [polypeptide binding]; other site 452471000026 25S rRNA binding site [nucleotide binding]; other site 452471000027 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 452471000028 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 452471000029 RNase E interface [polypeptide binding]; other site 452471000030 trimer interface [polypeptide binding]; other site 452471000031 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 452471000032 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 452471000033 RNase E interface [polypeptide binding]; other site 452471000034 trimer interface [polypeptide binding]; other site 452471000035 active site 452471000036 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 452471000037 putative nucleic acid binding region [nucleotide binding]; other site 452471000038 G-X-X-G motif; other site 452471000039 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 452471000040 RNA binding site [nucleotide binding]; other site 452471000041 domain interface; other site 452471000042 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 452471000043 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 452471000044 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452471000045 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452471000046 DNA binding residues [nucleotide binding] 452471000047 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 452471000048 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452471000049 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452471000050 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 452471000051 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 452471000052 active site 452471000053 substrate binding site [chemical binding]; other site 452471000054 metal binding site [ion binding]; metal-binding site 452471000055 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 452471000056 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 452471000057 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452471000058 catalytic residue [active] 452471000059 lipoprotein signal peptidase; Provisional; Region: PRK14788 452471000060 lipoprotein signal peptidase; Provisional; Region: PRK14787 452471000061 ADP-ribose binding site [chemical binding]; other site 452471000062 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 452471000063 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 452471000064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452471000065 S-adenosylmethionine binding site [chemical binding]; other site 452471000066 exopolyphosphatase; Region: exo_poly_only; TIGR03706 452471000067 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 452471000068 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452471000069 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 452471000070 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 452471000071 GIY-YIG motif/motif A; other site 452471000072 active site 452471000073 catalytic site [active] 452471000074 putative DNA binding site [nucleotide binding]; other site 452471000075 metal binding site [ion binding]; metal-binding site 452471000076 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 452471000077 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 452471000078 DNA binding site [nucleotide binding] 452471000079 F-box-like; Region: F-box-like; pfam12937 452471000080 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471000081 Substrate binding site [chemical binding]; other site 452471000082 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 452471000083 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 452471000084 Predicted permeases [General function prediction only]; Region: COG0795 452471000085 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 452471000086 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 452471000087 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 452471000088 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 452471000089 E3 interaction surface; other site 452471000090 lipoyl attachment site [posttranslational modification]; other site 452471000091 e3 binding domain; Region: E3_binding; pfam02817 452471000092 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 452471000093 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 452471000094 active site 452471000095 HslU subunit interaction site [polypeptide binding]; other site 452471000096 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471000097 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471000098 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471000099 Sel1-like repeats; Region: SEL1; smart00671 452471000100 Sel1-like repeats; Region: SEL1; smart00671 452471000101 Sel1 repeat; Region: Sel1; pfam08238 452471000102 Sel1-like repeats; Region: SEL1; smart00671 452471000103 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 452471000104 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 452471000105 hinge; other site 452471000106 active site 452471000107 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 452471000108 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 452471000109 Part of AAA domain; Region: AAA_19; pfam13245 452471000110 Family description; Region: UvrD_C_2; pfam13538 452471000111 SurA N-terminal domain; Region: SurA_N_3; cl07813 452471000112 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 452471000113 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 452471000114 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471000115 Na binding site [ion binding]; other site 452471000116 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452471000117 Zn2+ binding site [ion binding]; other site 452471000118 Mg2+ binding site [ion binding]; other site 452471000119 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 452471000120 G1 box; other site 452471000121 GTP/Mg2+ binding site [chemical binding]; other site 452471000122 G2 box; other site 452471000123 Switch I region; other site 452471000124 G3 box; other site 452471000125 Switch II region; other site 452471000126 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 452471000127 GTP/Mg2+ binding site [chemical binding]; other site 452471000128 G4 box; other site 452471000129 G5 box; other site 452471000130 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452471000131 G1 box; other site 452471000132 G1 box; other site 452471000133 GTP/Mg2+ binding site [chemical binding]; other site 452471000134 Switch I region; other site 452471000135 G2 box; other site 452471000136 G2 box; other site 452471000137 G3 box; other site 452471000138 G3 box; other site 452471000139 Switch II region; other site 452471000140 Switch II region; other site 452471000141 G4 box; other site 452471000142 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452471000143 G1 box; other site 452471000144 GTP/Mg2+ binding site [chemical binding]; other site 452471000145 G2 box; other site 452471000146 G3 box; other site 452471000147 Switch II region; other site 452471000148 G4 box; other site 452471000149 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 452471000150 G1 box; other site 452471000151 GTP/Mg2+ binding site [chemical binding]; other site 452471000152 G2 box; other site 452471000153 G3 box; other site 452471000154 Switch II region; other site 452471000155 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452471000156 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452471000157 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 452471000158 Walker A/P-loop; other site 452471000159 ATP binding site [chemical binding]; other site 452471000160 Q-loop/lid; other site 452471000161 ABC transporter signature motif; other site 452471000162 Walker B; other site 452471000163 D-loop; other site 452471000164 H-loop/switch region; other site 452471000165 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 452471000166 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 452471000167 dimerization interface 3.5A [polypeptide binding]; other site 452471000168 active site 452471000169 elongation factor Ts; Provisional; Region: tsf; PRK09377 452471000170 UBA/TS-N domain; Region: UBA; pfam00627 452471000171 Elongation factor TS; Region: EF_TS; pfam00889 452471000172 Elongation factor TS; Region: EF_TS; pfam00889 452471000173 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 452471000174 rRNA interaction site [nucleotide binding]; other site 452471000175 S8 interaction site; other site 452471000176 putative laminin-1 binding site; other site 452471000177 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 452471000178 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 452471000179 23S rRNA interface [nucleotide binding]; other site 452471000180 L3 interface [polypeptide binding]; other site 452471000181 transport protein TonB; Provisional; Region: PRK10819 452471000182 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 452471000183 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 452471000184 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 452471000185 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 452471000186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452471000187 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 452471000188 NAD(P) binding site [chemical binding]; other site 452471000189 active site 452471000190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471000191 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471000192 ATP synthase A chain; Region: ATP-synt_A; cl00413 452471000193 ATP synthase subunit C; Region: ATP-synt_C; cl00466 452471000194 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 452471000195 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 452471000196 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 452471000197 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 452471000198 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 452471000199 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 452471000200 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 452471000201 beta subunit interaction interface [polypeptide binding]; other site 452471000202 Walker A motif; other site 452471000203 ATP binding site [chemical binding]; other site 452471000204 Walker B motif; other site 452471000205 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 452471000206 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 452471000207 core domain interface [polypeptide binding]; other site 452471000208 delta subunit interface [polypeptide binding]; other site 452471000209 epsilon subunit interface [polypeptide binding]; other site 452471000210 TLC ATP/ADP transporter; Region: TLC; cl03940 452471000211 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 452471000212 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 452471000213 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 452471000214 dimer interface [polypeptide binding]; other site 452471000215 decamer (pentamer of dimers) interface [polypeptide binding]; other site 452471000216 catalytic triad [active] 452471000217 peroxidatic and resolving cysteines [active] 452471000218 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471000219 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 452471000220 EamA-like transporter family; Region: EamA; pfam00892 452471000221 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 452471000222 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452471000223 FtsX-like permease family; Region: FtsX; pfam02687 452471000224 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 452471000225 trimer interface [polypeptide binding]; other site 452471000226 active site 452471000227 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 452471000228 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 452471000229 active site 452471000230 Substrate binding site; other site 452471000231 Mg++ binding site; other site 452471000232 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 452471000233 putative trimer interface [polypeptide binding]; other site 452471000234 putative CoA binding site [chemical binding]; other site 452471000235 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 452471000236 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 452471000237 Peptidase family M23; Region: Peptidase_M23; pfam01551 452471000238 potential frameshift: common BLAST hit: gi|189502489|ref|YP_001958206.1| transposase IS4 family protein 452471000239 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471000240 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471000241 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 452471000242 dimer interface [polypeptide binding]; other site 452471000243 catalytic triad [active] 452471000244 Clp protease; Region: CLP_protease; pfam00574 452471000245 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 452471000246 active site 452471000247 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 452471000248 F-box-like; Region: F-box-like; pfam12937 452471000249 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471000250 Leucine-rich repeats; other site 452471000251 Substrate binding site [chemical binding]; other site 452471000252 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471000253 Leucine-rich repeats; other site 452471000254 Substrate binding site [chemical binding]; other site 452471000255 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471000256 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471000257 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 452471000258 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 452471000259 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 452471000260 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 452471000261 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 452471000262 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 452471000263 Protein export membrane protein; Region: SecD_SecF; pfam02355 452471000264 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471000265 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000266 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000267 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471000268 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000269 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 452471000270 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 452471000271 catalytic residues [active] 452471000272 catalytic nucleophile [active] 452471000273 Presynaptic Site I dimer interface [polypeptide binding]; other site 452471000274 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 452471000275 Synaptic Flat tetramer interface [polypeptide binding]; other site 452471000276 Synaptic Site I dimer interface [polypeptide binding]; other site 452471000277 DNA binding site [nucleotide binding] 452471000278 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 452471000279 DNA-binding interface [nucleotide binding]; DNA binding site 452471000280 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 452471000281 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 452471000282 Zn binding site [ion binding]; other site 452471000283 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 452471000284 hypothetical protein; Reviewed; Region: PRK00024 452471000285 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 452471000286 MPN+ (JAMM) motif; other site 452471000287 Zinc-binding site [ion binding]; other site 452471000288 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 452471000289 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 452471000290 putative tRNA-binding site [nucleotide binding]; other site 452471000291 B3/4 domain; Region: B3_4; pfam03483 452471000292 tRNA synthetase B5 domain; Region: B5; pfam03484 452471000293 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 452471000294 dimer interface [polypeptide binding]; other site 452471000295 motif 1; other site 452471000296 motif 3; other site 452471000297 motif 2; other site 452471000298 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 452471000299 Cell division protein ZapA; Region: ZapA; pfam05164 452471000300 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 452471000301 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 452471000302 NAD(P) binding site [chemical binding]; other site 452471000303 homotetramer interface [polypeptide binding]; other site 452471000304 homodimer interface [polypeptide binding]; other site 452471000305 active site 452471000306 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 452471000307 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 452471000308 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 452471000309 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 452471000310 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471000311 Substrate binding site [chemical binding]; other site 452471000312 A Receptor for Ubiquitination Targets; Region: FBOX; smart00256 452471000313 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471000314 Leucine-rich repeats; other site 452471000315 Substrate binding site [chemical binding]; other site 452471000316 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 452471000317 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 452471000318 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 452471000319 NAD(P) binding pocket [chemical binding]; other site 452471000320 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 452471000321 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 452471000322 PYR/PP interface [polypeptide binding]; other site 452471000323 dimer interface [polypeptide binding]; other site 452471000324 TPP binding site [chemical binding]; other site 452471000325 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 452471000326 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 452471000327 TPP-binding site [chemical binding]; other site 452471000328 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 452471000329 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452471000330 active site 452471000331 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 452471000332 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 452471000333 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 452471000334 Substrate binding site; other site 452471000335 Cupin domain; Region: Cupin_2; cl17218 452471000336 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 452471000337 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000338 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471000339 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000340 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471000341 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000342 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000343 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471000344 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471000345 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 452471000346 elongation factor G; Reviewed; Region: PRK12739 452471000347 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 452471000348 G1 box; other site 452471000349 putative GEF interaction site [polypeptide binding]; other site 452471000350 GTP/Mg2+ binding site [chemical binding]; other site 452471000351 Switch I region; other site 452471000352 G2 box; other site 452471000353 G3 box; other site 452471000354 Switch II region; other site 452471000355 G4 box; other site 452471000356 G5 box; other site 452471000357 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 452471000358 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 452471000359 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 452471000360 30S ribosomal protein S7; Validated; Region: PRK05302 452471000361 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 452471000362 S17 interaction site [polypeptide binding]; other site 452471000363 S8 interaction site; other site 452471000364 16S rRNA interaction site [nucleotide binding]; other site 452471000365 streptomycin interaction site [chemical binding]; other site 452471000366 23S rRNA interaction site [nucleotide binding]; other site 452471000367 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 452471000368 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471000369 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 452471000370 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471000371 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 452471000372 PLD-like domain; Region: PLDc_2; pfam13091 452471000373 putative active site [active] 452471000374 catalytic site [active] 452471000375 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471000376 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471000377 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 452471000378 catalytic motif [active] 452471000379 Catalytic residue [active] 452471000380 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471000381 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 452471000382 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 452471000383 active site 452471000384 catalytic site [active] 452471000385 substrate binding site [chemical binding]; other site 452471000386 transcription termination factor NusA; Region: NusA; TIGR01953 452471000387 NusA N-terminal domain; Region: NusA_N; pfam08529 452471000388 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 452471000389 RNA binding site [nucleotide binding]; other site 452471000390 homodimer interface [polypeptide binding]; other site 452471000391 NusA-like KH domain; Region: KH_5; pfam13184 452471000392 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 452471000393 G-X-X-G motif; other site 452471000394 translation initiation factor IF-2; Validated; Region: infB; PRK05306 452471000395 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 452471000396 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 452471000397 G1 box; other site 452471000398 putative GEF interaction site [polypeptide binding]; other site 452471000399 GTP/Mg2+ binding site [chemical binding]; other site 452471000400 Switch I region; other site 452471000401 G2 box; other site 452471000402 G3 box; other site 452471000403 Switch II region; other site 452471000404 G4 box; other site 452471000405 G5 box; other site 452471000406 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 452471000407 Translation-initiation factor 2; Region: IF-2; pfam11987 452471000408 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 452471000409 Haemolytic domain; Region: Haemolytic; pfam01809 452471000410 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 452471000411 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452471000412 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 452471000413 active site 452471000414 DNA binding site [nucleotide binding] 452471000415 Int/Topo IB signature motif; other site 452471000416 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 452471000417 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 452471000418 dimer interface [polypeptide binding]; other site 452471000419 anticodon binding site; other site 452471000420 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 452471000421 homodimer interface [polypeptide binding]; other site 452471000422 motif 1; other site 452471000423 active site 452471000424 motif 2; other site 452471000425 GAD domain; Region: GAD; pfam02938 452471000426 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452471000427 active site 452471000428 motif 3; other site 452471000429 enolase; Provisional; Region: eno; PRK00077 452471000430 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 452471000431 dimer interface [polypeptide binding]; other site 452471000432 metal binding site [ion binding]; metal-binding site 452471000433 substrate binding pocket [chemical binding]; other site 452471000434 DNA polymerase III subunit beta; Validated; Region: PRK05643 452471000435 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 452471000436 putative DNA binding surface [nucleotide binding]; other site 452471000437 dimer interface [polypeptide binding]; other site 452471000438 beta-clamp/clamp loader binding surface; other site 452471000439 beta-clamp/translesion DNA polymerase binding surface; other site 452471000440 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 452471000441 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 452471000442 homodimer interface [polypeptide binding]; other site 452471000443 oligonucleotide binding site [chemical binding]; other site 452471000444 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 452471000445 IHF - DNA interface [nucleotide binding]; other site 452471000446 IHF dimer interface [polypeptide binding]; other site 452471000447 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 452471000448 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 452471000449 minor groove reading motif; other site 452471000450 helix-hairpin-helix signature motif; other site 452471000451 substrate binding pocket [chemical binding]; other site 452471000452 active site 452471000453 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 452471000454 DNA binding and oxoG recognition site [nucleotide binding] 452471000455 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 452471000456 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 452471000457 dimer interface [polypeptide binding]; other site 452471000458 ssDNA binding site [nucleotide binding]; other site 452471000459 tetramer (dimer of dimers) interface [polypeptide binding]; other site 452471000460 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471000461 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471000462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 452471000463 Transposase; Region: DEDD_Tnp_IS110; pfam01548 452471000464 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 452471000465 Family of unknown function (DUF490); Region: DUF490; pfam04357 452471000466 UGMP family protein; Validated; Region: PRK09604 452471000467 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 452471000468 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 452471000469 SmpB-tmRNA interface; other site 452471000470 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 452471000471 Protein of unknown function (DUF502); Region: DUF502; pfam04367 452471000472 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 452471000473 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 452471000474 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 452471000475 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 452471000476 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 452471000477 alphaNTD homodimer interface [polypeptide binding]; other site 452471000478 alphaNTD - beta interaction site [polypeptide binding]; other site 452471000479 alphaNTD - beta' interaction site [polypeptide binding]; other site 452471000480 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 452471000481 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 452471000482 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 452471000483 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 452471000484 RNA binding surface [nucleotide binding]; other site 452471000485 30S ribosomal protein S11; Validated; Region: PRK05309 452471000486 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 452471000487 30S ribosomal protein S13; Region: bact_S13; TIGR03631 452471000488 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 452471000489 rRNA binding site [nucleotide binding]; other site 452471000490 predicted 30S ribosome binding site; other site 452471000491 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 452471000492 active site 452471000493 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 452471000494 SecY translocase; Region: SecY; pfam00344 452471000495 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 452471000496 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 452471000497 23S rRNA binding site [nucleotide binding]; other site 452471000498 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 452471000499 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 452471000500 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 452471000501 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 452471000502 5S rRNA interface [nucleotide binding]; other site 452471000503 23S rRNA interface [nucleotide binding]; other site 452471000504 L5 interface [polypeptide binding]; other site 452471000505 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 452471000506 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 452471000507 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 452471000508 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 452471000509 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 452471000510 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 452471000511 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 452471000512 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 452471000513 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 452471000514 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 452471000515 RNA binding site [nucleotide binding]; other site 452471000516 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 452471000517 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 452471000518 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 452471000519 L23 interface [polypeptide binding]; other site 452471000520 signal recognition particle (SRP54) interaction site; other site 452471000521 trigger factor interaction site; other site 452471000522 23S rRNA interface [nucleotide binding]; other site 452471000523 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 452471000524 23S rRNA interface [nucleotide binding]; other site 452471000525 5S rRNA interface [nucleotide binding]; other site 452471000526 putative antibiotic binding site [chemical binding]; other site 452471000527 L25 interface [polypeptide binding]; other site 452471000528 L27 interface [polypeptide binding]; other site 452471000529 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 452471000530 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 452471000531 G-X-X-G motif; other site 452471000532 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 452471000533 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 452471000534 protein-rRNA interface [nucleotide binding]; other site 452471000535 putative translocon binding site; other site 452471000536 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 452471000537 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 452471000538 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 452471000539 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 452471000540 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 452471000541 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 452471000542 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 452471000543 BioY family; Region: BioY; pfam02632 452471000544 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452471000545 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 452471000546 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 452471000547 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 452471000548 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 452471000549 putative active site [active] 452471000550 putative metal binding site [ion binding]; other site 452471000551 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 452471000552 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452471000553 Walker A/P-loop; other site 452471000554 ATP binding site [chemical binding]; other site 452471000555 Q-loop/lid; other site 452471000556 ABC transporter signature motif; other site 452471000557 Walker B; other site 452471000558 D-loop; other site 452471000559 H-loop/switch region; other site 452471000560 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 452471000561 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 452471000562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452471000563 Walker A/P-loop; other site 452471000564 ATP binding site [chemical binding]; other site 452471000565 Q-loop/lid; other site 452471000566 ABC transporter signature motif; other site 452471000567 Walker B; other site 452471000568 D-loop; other site 452471000569 H-loop/switch region; other site 452471000570 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452471000571 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 452471000572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452471000573 dimer interface [polypeptide binding]; other site 452471000574 conserved gate region; other site 452471000575 putative PBP binding loops; other site 452471000576 ABC-ATPase subunit interface; other site 452471000577 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452471000578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452471000579 dimer interface [polypeptide binding]; other site 452471000580 conserved gate region; other site 452471000581 putative PBP binding loops; other site 452471000582 ABC-ATPase subunit interface; other site 452471000583 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 452471000584 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 452471000585 Bacterial Ig-like domain; Region: Big_5; pfam13205 452471000586 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471000587 Na binding site [ion binding]; other site 452471000588 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452471000589 Zn2+ binding site [ion binding]; other site 452471000590 Mg2+ binding site [ion binding]; other site 452471000591 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 452471000592 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 452471000593 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 452471000594 putative active site [active] 452471000595 putative metal binding site [ion binding]; other site 452471000596 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 452471000597 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452471000598 Walker A/P-loop; other site 452471000599 ATP binding site [chemical binding]; other site 452471000600 Q-loop/lid; other site 452471000601 ABC transporter signature motif; other site 452471000602 Walker B; other site 452471000603 D-loop; other site 452471000604 H-loop/switch region; other site 452471000605 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 452471000606 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 452471000607 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452471000608 Walker A/P-loop; other site 452471000609 ATP binding site [chemical binding]; other site 452471000610 Q-loop/lid; other site 452471000611 ABC transporter signature motif; other site 452471000612 Walker B; other site 452471000613 D-loop; other site 452471000614 H-loop/switch region; other site 452471000615 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452471000616 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 452471000617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452471000618 dimer interface [polypeptide binding]; other site 452471000619 conserved gate region; other site 452471000620 putative PBP binding loops; other site 452471000621 ABC-ATPase subunit interface; other site 452471000622 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452471000623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452471000624 dimer interface [polypeptide binding]; other site 452471000625 conserved gate region; other site 452471000626 putative PBP binding loops; other site 452471000627 ABC-ATPase subunit interface; other site 452471000628 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 452471000629 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 452471000630 Bacterial Ig-like domain; Region: Big_5; pfam13205 452471000631 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471000632 Na binding site [ion binding]; other site 452471000633 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452471000634 Zn2+ binding site [ion binding]; other site 452471000635 Mg2+ binding site [ion binding]; other site 452471000636 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cl03649 452471000637 DDE domain; Region: DDE_Tnp_IS240; pfam13610 452471000638 Integrase core domain; Region: rve; pfam00665 452471000639 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 452471000640 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 452471000641 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 452471000642 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452471000643 Walker A/P-loop; other site 452471000644 ATP binding site [chemical binding]; other site 452471000645 Q-loop/lid; other site 452471000646 ABC transporter signature motif; other site 452471000647 Walker B; other site 452471000648 D-loop; other site 452471000649 H-loop/switch region; other site 452471000650 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 452471000651 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 452471000652 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 452471000653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452471000654 FeS/SAM binding site; other site 452471000655 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000656 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471000657 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000658 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000659 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471000660 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471000661 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471000662 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471000663 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000664 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471000665 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000666 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471000667 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000668 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 452471000669 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 452471000670 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 452471000671 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 452471000672 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 452471000673 PLD-like domain; Region: PLDc_2; pfam13091 452471000674 putative active site [active] 452471000675 catalytic site [active] 452471000676 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471000677 Ankyrin repeat; Region: Ank; pfam00023 452471000678 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471000679 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000680 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471000681 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000682 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471000683 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471000684 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471000685 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 452471000686 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 452471000687 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 452471000688 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 452471000689 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 452471000690 nucleoside/Zn binding site; other site 452471000691 dimer interface [polypeptide binding]; other site 452471000692 catalytic motif [active] 452471000693 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 452471000694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471000695 Walker A motif; other site 452471000696 ATP binding site [chemical binding]; other site 452471000697 Walker B motif; other site 452471000698 arginine finger; other site 452471000699 Peptidase family M41; Region: Peptidase_M41; pfam01434 452471000700 Oligomerisation domain; Region: Oligomerisation; pfam02410 452471000701 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 452471000702 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 452471000703 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 452471000704 HD domain; Region: HD_4; pfam13328 452471000705 membrane protein insertase; Provisional; Region: PRK01318 452471000706 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 452471000707 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 452471000708 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 452471000709 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 452471000710 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 452471000711 FeS assembly ATPase SufC; Region: sufC; TIGR01978 452471000712 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 452471000713 Walker A/P-loop; other site 452471000714 ATP binding site [chemical binding]; other site 452471000715 Q-loop/lid; other site 452471000716 ABC transporter signature motif; other site 452471000717 Walker B; other site 452471000718 D-loop; other site 452471000719 H-loop/switch region; other site 452471000720 FeS assembly protein SufD; Region: sufD; TIGR01981 452471000721 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 452471000722 Ribosome-binding factor A; Region: RBFA; pfam02033 452471000723 triosephosphate isomerase; Provisional; Region: PRK14567 452471000724 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 452471000725 substrate binding site [chemical binding]; other site 452471000726 dimer interface [polypeptide binding]; other site 452471000727 catalytic triad [active] 452471000728 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 452471000729 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 452471000730 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 452471000731 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 452471000732 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 452471000733 rod shape-determining protein MreC; Provisional; Region: PRK13922 452471000734 rod shape-determining protein MreC; Region: MreC; pfam04085 452471000735 rod shape-determining protein MreB; Provisional; Region: PRK13927 452471000736 MreB and similar proteins; Region: MreB_like; cd10225 452471000737 nucleotide binding site [chemical binding]; other site 452471000738 Mg binding site [ion binding]; other site 452471000739 putative protofilament interaction site [polypeptide binding]; other site 452471000740 RodZ interaction site [polypeptide binding]; other site 452471000741 potential frameshift: common BLAST hit: gi|189502533|ref|YP_001958250.1| transposase IS4 family protein 452471000742 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471000743 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452471000744 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471000745 gliding motility associated protien GldN; Region: GldN; TIGR03523 452471000746 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 452471000747 GldM N-terminal domain; Region: GldM_N; pfam12081 452471000748 GldM C-terminal domain; Region: GldM_C; pfam12080 452471000749 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 452471000750 gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529 452471000751 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 452471000752 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 452471000753 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 452471000754 Mg++ binding site [ion binding]; other site 452471000755 putative catalytic motif [active] 452471000756 putative substrate binding site [chemical binding]; other site 452471000757 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 452471000758 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 452471000759 dimer interface [polypeptide binding]; other site 452471000760 motif 1; other site 452471000761 active site 452471000762 motif 2; other site 452471000763 motif 3; other site 452471000764 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 452471000765 anticodon binding site; other site 452471000766 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471000767 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 452471000768 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 452471000769 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 452471000770 transcription termination factor Rho; Provisional; Region: PRK12608 452471000771 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 452471000772 RNA binding site [nucleotide binding]; other site 452471000773 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 452471000774 multimer interface [polypeptide binding]; other site 452471000775 Walker A motif; other site 452471000776 ATP binding site [chemical binding]; other site 452471000777 Walker B motif; other site 452471000778 seryl-tRNA synthetase; Provisional; Region: PRK05431 452471000779 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 452471000780 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452471000781 motif 1; other site 452471000782 dimer interface [polypeptide binding]; other site 452471000783 active site 452471000784 motif 2; other site 452471000785 motif 3; other site 452471000786 adenylate kinase; Reviewed; Region: adk; PRK00279 452471000787 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 452471000788 AMP-binding site [chemical binding]; other site 452471000789 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 452471000790 GTPase CgtA; Reviewed; Region: obgE; PRK12299 452471000791 GTP1/OBG; Region: GTP1_OBG; pfam01018 452471000792 Obg GTPase; Region: Obg; cd01898 452471000793 G1 box; other site 452471000794 GTP/Mg2+ binding site [chemical binding]; other site 452471000795 Switch I region; other site 452471000796 G2 box; other site 452471000797 G3 box; other site 452471000798 Switch II region; other site 452471000799 G4 box; other site 452471000800 G5 box; other site 452471000801 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 452471000802 putative hydrophobic ligand binding site [chemical binding]; other site 452471000803 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 452471000804 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452471000805 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452471000806 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 452471000807 Walker A/P-loop; other site 452471000808 ATP binding site [chemical binding]; other site 452471000809 Q-loop/lid; other site 452471000810 ABC transporter signature motif; other site 452471000811 Walker B; other site 452471000812 D-loop; other site 452471000813 H-loop/switch region; other site 452471000814 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471000815 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 452471000816 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 452471000817 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452471000818 ATP binding site [chemical binding]; other site 452471000819 putative Mg++ binding site [ion binding]; other site 452471000820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452471000821 nucleotide binding region [chemical binding]; other site 452471000822 ATP-binding site [chemical binding]; other site 452471000823 TRCF domain; Region: TRCF; pfam03461 452471000824 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 452471000825 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 452471000826 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 452471000827 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 452471000828 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 452471000829 dimer interface [polypeptide binding]; other site 452471000830 active site 452471000831 glycine-pyridoxal phosphate binding site [chemical binding]; other site 452471000832 folate binding site [chemical binding]; other site 452471000833 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 452471000834 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 452471000835 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 452471000836 prolyl-tRNA synthetase; Provisional; Region: PRK08661 452471000837 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 452471000838 dimer interface [polypeptide binding]; other site 452471000839 motif 1; other site 452471000840 active site 452471000841 motif 2; other site 452471000842 motif 3; other site 452471000843 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 452471000844 anticodon binding site; other site 452471000845 zinc-binding site [ion binding]; other site 452471000846 proline aminopeptidase P II; Provisional; Region: PRK10879 452471000847 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 452471000848 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 452471000849 active site 452471000850 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 452471000851 DNA binding site [nucleotide binding] 452471000852 active site 452471000853 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 452471000854 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 452471000855 putative acyl-acceptor binding pocket; other site 452471000856 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 452471000857 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 452471000858 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 452471000859 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 452471000860 A new structural DNA glycosylase; Region: AlkD_like; cd06561 452471000861 active site 452471000862 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 452471000863 Helix-turn-helix domain; Region: HTH_18; pfam12833 452471000864 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 452471000865 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 452471000866 DNA binding site [nucleotide binding] 452471000867 active site 452471000868 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 452471000869 phosphoglyceromutase; Provisional; Region: PRK05434 452471000870 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 452471000871 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 452471000872 active site 452471000873 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 452471000874 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 452471000875 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 452471000876 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 452471000877 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 452471000878 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 452471000879 trimer interface [polypeptide binding]; other site 452471000880 active site 452471000881 UDP-GlcNAc binding site [chemical binding]; other site 452471000882 lipid binding site [chemical binding]; lipid-binding site 452471000883 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 452471000884 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 452471000885 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452471000886 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452471000887 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452471000888 nudix motif; other site 452471000889 excinuclease ABC subunit B; Provisional; Region: PRK05298 452471000890 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452471000891 ATP binding site [chemical binding]; other site 452471000892 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452471000893 nucleotide binding region [chemical binding]; other site 452471000894 ATP-binding site [chemical binding]; other site 452471000895 Ultra-violet resistance protein B; Region: UvrB; pfam12344 452471000896 UvrB/uvrC motif; Region: UVR; pfam02151 452471000897 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 452471000898 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 452471000899 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471000900 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 452471000901 ApbE family; Region: ApbE; pfam02424 452471000902 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 452471000903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471000904 Walker A motif; other site 452471000905 ATP binding site [chemical binding]; other site 452471000906 Walker B motif; other site 452471000907 arginine finger; other site 452471000908 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 452471000909 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 452471000910 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 452471000911 folate binding site [chemical binding]; other site 452471000912 NADP+ binding site [chemical binding]; other site 452471000913 competence damage-inducible protein A; Provisional; Region: PRK00549 452471000914 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 452471000915 putative MPT binding site; other site 452471000916 Competence-damaged protein; Region: CinA; pfam02464 452471000917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471000918 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471000919 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 452471000920 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452471000921 Catalytic site [active] 452471000922 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452471000923 dihydrodipicolinate reductase; Provisional; Region: PRK00048 452471000924 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 452471000925 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 452471000926 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 452471000927 ParB-like nuclease domain; Region: ParBc; pfam02195 452471000928 KorB domain; Region: KorB; pfam08535 452471000929 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 452471000930 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 452471000931 P-loop; other site 452471000932 Magnesium ion binding site [ion binding]; other site 452471000933 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 452471000934 Magnesium ion binding site [ion binding]; other site 452471000935 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 452471000936 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 452471000937 ring oligomerisation interface [polypeptide binding]; other site 452471000938 ATP/Mg binding site [chemical binding]; other site 452471000939 stacking interactions; other site 452471000940 hinge regions; other site 452471000941 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 452471000942 oligomerisation interface [polypeptide binding]; other site 452471000943 mobile loop; other site 452471000944 roof hairpin; other site 452471000945 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 452471000946 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 452471000947 generic binding surface II; other site 452471000948 ssDNA binding site; other site 452471000949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452471000950 ATP binding site [chemical binding]; other site 452471000951 putative Mg++ binding site [ion binding]; other site 452471000952 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452471000953 nucleotide binding region [chemical binding]; other site 452471000954 ATP-binding site [chemical binding]; other site 452471000955 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471000956 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 452471000957 catalytic residues [active] 452471000958 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471000959 Sel1-like repeats; Region: SEL1; smart00671 452471000960 Sel1-like repeats; Region: SEL1; smart00671 452471000961 Sel1-like repeats; Region: SEL1; smart00671 452471000962 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471000963 Substrate binding site [chemical binding]; other site 452471000964 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 452471000965 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471000966 Leucine-rich repeats; other site 452471000967 Leucine rich repeat; Region: LRR_8; pfam13855 452471000968 Leucine rich repeat; Region: LRR_8; pfam13855 452471000969 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 452471000970 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 452471000971 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 452471000972 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 452471000973 NodB motif; other site 452471000974 putative active site [active] 452471000975 putative catalytic site [active] 452471000976 putative Zn binding site [ion binding]; other site 452471000977 DNA polymerase I; Provisional; Region: PRK05755 452471000978 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 452471000979 active site 452471000980 metal binding site 1 [ion binding]; metal-binding site 452471000981 putative 5' ssDNA interaction site; other site 452471000982 metal binding site 3; metal-binding site 452471000983 metal binding site 2 [ion binding]; metal-binding site 452471000984 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 452471000985 putative DNA binding site [nucleotide binding]; other site 452471000986 putative metal binding site [ion binding]; other site 452471000987 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 452471000988 active site 452471000989 catalytic site [active] 452471000990 substrate binding site [chemical binding]; other site 452471000991 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 452471000992 active site 452471000993 DNA binding site [nucleotide binding] 452471000994 catalytic site [active] 452471000995 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 452471000996 tetramer interface [polypeptide binding]; other site 452471000997 TPP-binding site [chemical binding]; other site 452471000998 heterodimer interface [polypeptide binding]; other site 452471000999 phosphorylation loop region [posttranslational modification] 452471001000 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 452471001001 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 452471001002 PYR/PP interface [polypeptide binding]; other site 452471001003 dimer interface [polypeptide binding]; other site 452471001004 TPP binding site [chemical binding]; other site 452471001005 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 452471001006 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 452471001007 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452471001008 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 452471001009 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471001010 Na binding site [ion binding]; other site 452471001011 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 452471001012 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 452471001013 substrate binding site [chemical binding]; other site 452471001014 oxyanion hole (OAH) forming residues; other site 452471001015 trimer interface [polypeptide binding]; other site 452471001016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471001017 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471001018 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00197 452471001019 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452471001020 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 452471001021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471001022 Walker A motif; other site 452471001023 ATP binding site [chemical binding]; other site 452471001024 Walker B motif; other site 452471001025 arginine finger; other site 452471001026 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 452471001027 recombination factor protein RarA; Reviewed; Region: PRK13342 452471001028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471001029 Walker A motif; other site 452471001030 ATP binding site [chemical binding]; other site 452471001031 Walker B motif; other site 452471001032 arginine finger; other site 452471001033 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 452471001034 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471001035 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 452471001036 nucleophilic elbow; other site 452471001037 catalytic triad; other site 452471001038 AAA ATPase domain; Region: AAA_16; pfam13191 452471001039 AAA domain; Region: AAA_22; pfam13401 452471001040 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471001041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471001042 binding surface 452471001043 TPR motif; other site 452471001044 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471001045 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001046 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471001047 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001048 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001049 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001050 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001051 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001052 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001053 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001054 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001055 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001056 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001057 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001058 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001059 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001060 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001061 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471001062 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471001063 Sel1-like repeats; Region: SEL1; smart00671 452471001064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471001065 binding surface 452471001066 TPR motif; other site 452471001067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471001068 binding surface 452471001069 TPR motif; other site 452471001070 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 452471001071 nucleophilic elbow; other site 452471001072 catalytic triad; other site 452471001073 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 452471001074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471001075 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471001076 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471001077 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452471001078 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452471001079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452471001080 Walker A/P-loop; other site 452471001081 ATP binding site [chemical binding]; other site 452471001082 Q-loop/lid; other site 452471001083 ABC transporter signature motif; other site 452471001084 Walker B; other site 452471001085 D-loop; other site 452471001086 H-loop/switch region; other site 452471001087 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 452471001088 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452471001089 FeS/SAM binding site; other site 452471001090 HemN C-terminal domain; Region: HemN_C; pfam06969 452471001091 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 452471001092 Malic enzyme, N-terminal domain; Region: malic; pfam00390 452471001093 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 452471001094 NAD(P) binding pocket [chemical binding]; other site 452471001095 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471001096 Na binding site [ion binding]; other site 452471001097 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 452471001098 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452471001099 Zn2+ binding site [ion binding]; other site 452471001100 Mg2+ binding site [ion binding]; other site 452471001101 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 452471001102 Glycoprotease family; Region: Peptidase_M22; pfam00814 452471001103 ribonuclease P; Reviewed; Region: rnpA; PRK01903 452471001104 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 452471001105 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 452471001106 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452471001107 active site 452471001108 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 452471001109 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 452471001110 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 452471001111 glycyl-tRNA synthetase; Provisional; Region: PRK04173 452471001112 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452471001113 motif 1; other site 452471001114 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 452471001115 active site 452471001116 motif 2; other site 452471001117 motif 3; other site 452471001118 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 452471001119 anticodon binding site; other site 452471001120 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471001121 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001122 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001123 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001124 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001125 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001126 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001127 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001128 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001129 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001130 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001131 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001132 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001133 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001134 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452471001136 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452471001137 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 452471001138 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452471001139 FtsX-like permease family; Region: FtsX; pfam02687 452471001140 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471001141 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 452471001142 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 452471001143 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 452471001144 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 452471001145 nucleotide binding site [chemical binding]; other site 452471001146 substrate binding site [chemical binding]; other site 452471001147 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 452471001148 AMP binding site [chemical binding]; other site 452471001149 metal binding site [ion binding]; metal-binding site 452471001150 active site 452471001151 seryl-tRNA synthetase; Provisional; Region: PRK05431 452471001152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471001153 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471001154 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452471001155 G1 box; other site 452471001156 GTP/Mg2+ binding site [chemical binding]; other site 452471001157 G2 box; other site 452471001158 Switch I region; other site 452471001159 G3 box; other site 452471001160 Switch II region; other site 452471001161 Zinc finger, C3HC4 type (RING finger); Region: zf-C3HC4_2; pfam13923 452471001162 RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably...; Region: RING; cd00162 452471001163 cross-brace motif; other site 452471001164 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 452471001165 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 452471001166 oligomer interface [polypeptide binding]; other site 452471001167 active site 452471001168 metal binding site [ion binding]; metal-binding site 452471001169 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 452471001170 Ferritin-like domain; Region: Ferritin; pfam00210 452471001171 ferroxidase diiron center [ion binding]; other site 452471001172 potential frameshift: common BLAST hit: gi|189502533|ref|YP_001958250.1| transposase IS4 family protein 452471001173 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471001174 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452471001175 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471001176 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471001177 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471001178 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471001179 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471001180 4Fe-4S binding domain; Region: Fer4; pfam00037 452471001181 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 452471001182 GTP-binding protein YchF; Reviewed; Region: PRK09601 452471001183 YchF GTPase; Region: YchF; cd01900 452471001184 G1 box; other site 452471001185 GTP/Mg2+ binding site [chemical binding]; other site 452471001186 Switch I region; other site 452471001187 G2 box; other site 452471001188 Switch II region; other site 452471001189 G3 box; other site 452471001190 G4 box; other site 452471001191 G5 box; other site 452471001192 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 452471001193 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471001194 Na binding site [ion binding]; other site 452471001195 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 452471001196 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 452471001197 RNA binding site [nucleotide binding]; other site 452471001198 active site 452471001199 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 452471001200 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 452471001201 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 452471001202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471001203 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471001204 Modified RING finger domain; Region: Ubox; smart00504 452471001205 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001206 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001207 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001208 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001209 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001210 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001211 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001212 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 452471001213 substrate binding site [chemical binding]; other site 452471001214 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 452471001215 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 452471001216 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 452471001217 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 452471001218 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 452471001219 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 452471001220 ligand binding site [chemical binding]; other site 452471001221 active site 452471001222 UGI interface [polypeptide binding]; other site 452471001223 catalytic site [active] 452471001224 hypothetical protein; Provisional; Region: PRK08201 452471001225 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 452471001226 metal binding site [ion binding]; metal-binding site 452471001227 putative dimer interface [polypeptide binding]; other site 452471001228 thiamine-monophosphate kinase; Region: thiL; TIGR01379 452471001229 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 452471001230 ATP binding site [chemical binding]; other site 452471001231 dimerization interface [polypeptide binding]; other site 452471001232 YtxH-like protein; Region: YtxH; cl02079 452471001233 DoxX; Region: DoxX; pfam07681 452471001234 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 452471001235 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 452471001236 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001237 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 452471001238 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001239 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001240 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001241 Preprotein translocase subunit; Region: YajC; pfam02699 452471001242 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 452471001243 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 452471001244 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 452471001245 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 452471001246 NAD binding site [chemical binding]; other site 452471001247 Phe binding site; other site 452471001248 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 452471001249 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 452471001250 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 452471001251 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 452471001252 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 452471001253 Uncharacterized conserved protein [Function unknown]; Region: COG0327 452471001254 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 452471001255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 452471001256 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 452471001257 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 452471001258 Putative zinc ribbon domain; Region: DUF164; pfam02591 452471001259 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 452471001260 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 452471001261 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 452471001262 RNA binding surface [nucleotide binding]; other site 452471001263 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 452471001264 active site 452471001265 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 452471001266 active site 452471001267 nucleophile elbow; other site 452471001268 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471001269 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 452471001270 Sel1-like repeats; Region: SEL1; smart00671 452471001271 Sel1-like repeats; Region: SEL1; smart00671 452471001272 TPR repeat; Region: TPR_11; pfam13414 452471001273 Sel1-like repeats; Region: SEL1; smart00671 452471001274 Sel1-like repeats; Region: SEL1; smart00671 452471001275 Sel1-like repeats; Region: SEL1; smart00671 452471001276 Sel1-like repeats; Region: SEL1; smart00671 452471001277 Sel1-like repeats; Region: SEL1; smart00671 452471001278 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471001279 Sel1-like repeats; Region: SEL1; smart00671 452471001280 Sel1-like repeats; Region: SEL1; smart00671 452471001281 Sel1-like repeats; Region: SEL1; smart00671 452471001282 Sel1-like repeats; Region: SEL1; smart00671 452471001283 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471001284 Sel1-like repeats; Region: SEL1; smart00671 452471001285 Sel1-like repeats; Region: SEL1; smart00671 452471001286 Sel1-like repeats; Region: SEL1; smart00671 452471001287 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471001288 Sel1-like repeats; Region: SEL1; smart00671 452471001289 Sel1-like repeats; Region: SEL1; smart00671 452471001290 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 452471001291 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452471001292 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452471001293 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 452471001294 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 452471001295 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452471001296 active site 452471001297 HIGH motif; other site 452471001298 nucleotide binding site [chemical binding]; other site 452471001299 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 452471001300 active site 452471001301 KMSKS motif; other site 452471001302 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 452471001303 tRNA binding surface [nucleotide binding]; other site 452471001304 anticodon binding site; other site 452471001305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471001306 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471001307 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 452471001308 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 452471001309 conserved cys residue [active] 452471001310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452471001311 Helix-turn-helix domain; Region: HTH_18; pfam12833 452471001312 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 452471001313 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452471001314 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452471001315 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452471001316 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 452471001317 Walker A/P-loop; other site 452471001318 ATP binding site [chemical binding]; other site 452471001319 Q-loop/lid; other site 452471001320 ABC transporter signature motif; other site 452471001321 Walker B; other site 452471001322 D-loop; other site 452471001323 H-loop/switch region; other site 452471001324 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452471001325 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452471001326 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471001327 Na binding site [ion binding]; other site 452471001328 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471001329 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471001330 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471001331 Na binding site [ion binding]; other site 452471001332 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452471001333 Zn2+ binding site [ion binding]; other site 452471001334 Mg2+ binding site [ion binding]; other site 452471001335 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 452471001336 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 452471001337 Competence protein; Region: Competence; pfam03772 452471001338 Modified RING finger domain; Region: Ubox; smart00504 452471001339 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452471001340 G1 box; other site 452471001341 GTP/Mg2+ binding site [chemical binding]; other site 452471001342 G2 box; other site 452471001343 Switch I region; other site 452471001344 G3 box; other site 452471001345 Switch II region; other site 452471001346 G4 box; other site 452471001347 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 452471001348 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 452471001349 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 452471001350 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471001351 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 452471001352 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 452471001353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452471001354 putative substrate translocation pore; other site 452471001355 WbqC-like protein family; Region: WbqC; pfam08889 452471001356 Clp amino terminal domain; Region: Clp_N; pfam02861 452471001357 Clp amino terminal domain; Region: Clp_N; pfam02861 452471001358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471001359 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 452471001360 Walker A motif; other site 452471001361 ATP binding site [chemical binding]; other site 452471001362 Walker B motif; other site 452471001363 arginine finger; other site 452471001364 UvrB/uvrC motif; Region: UVR; pfam02151 452471001365 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 452471001366 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 452471001367 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 452471001368 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471001369 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 452471001370 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 452471001371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452471001372 putative substrate translocation pore; other site 452471001373 WbqC-like protein family; Region: WbqC; pfam08889 452471001374 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 452471001375 Clp amino terminal domain; Region: Clp_N; pfam02861 452471001376 Clp amino terminal domain; Region: Clp_N; pfam02861 452471001377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471001378 Walker A motif; other site 452471001379 ATP binding site [chemical binding]; other site 452471001380 Walker B motif; other site 452471001381 arginine finger; other site 452471001382 UvrB/uvrC motif; Region: UVR; pfam02151 452471001383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471001384 Walker A motif; other site 452471001385 ATP binding site [chemical binding]; other site 452471001386 Walker B motif; other site 452471001387 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 452471001388 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 452471001389 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 452471001390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452471001391 Walker A/P-loop; other site 452471001392 ATP binding site [chemical binding]; other site 452471001393 Q-loop/lid; other site 452471001394 ABC transporter signature motif; other site 452471001395 Walker B; other site 452471001396 D-loop; other site 452471001397 H-loop/switch region; other site 452471001398 GH3 auxin-responsive promoter; Region: GH3; pfam03321 452471001399 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 452471001400 RIP metalloprotease RseP; Region: TIGR00054 452471001401 active site 452471001402 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 452471001403 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 452471001404 protein binding site [polypeptide binding]; other site 452471001405 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 452471001406 putative substrate binding region [chemical binding]; other site 452471001407 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 452471001408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471001409 Walker A motif; other site 452471001410 ATP binding site [chemical binding]; other site 452471001411 Walker B motif; other site 452471001412 arginine finger; other site 452471001413 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 452471001414 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 452471001415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471001416 Walker A motif; other site 452471001417 ATP binding site [chemical binding]; other site 452471001418 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 452471001419 Walker B motif; other site 452471001420 arginine finger; other site 452471001421 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 452471001422 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471001423 Sel1-like repeats; Region: SEL1; smart00671 452471001424 Sel1-like repeats; Region: SEL1; smart00671 452471001425 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 452471001426 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 452471001427 active site 452471001428 multimer interface [polypeptide binding]; other site 452471001429 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 452471001430 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 452471001431 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 452471001432 dimer interface [polypeptide binding]; other site 452471001433 motif 1; other site 452471001434 active site 452471001435 motif 2; other site 452471001436 motif 3; other site 452471001437 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 452471001438 hypothetical protein; Provisional; Region: PRK08609 452471001439 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 452471001440 metal binding triad [ion binding]; metal-binding site 452471001441 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 452471001442 active site 452471001443 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 452471001444 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 452471001445 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 452471001446 putative acyl-acceptor binding pocket; other site 452471001447 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 452471001448 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 452471001449 nucleotide binding site [chemical binding]; other site 452471001450 NEF interaction site [polypeptide binding]; other site 452471001451 SBD interface [polypeptide binding]; other site 452471001452 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 452471001453 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 452471001454 5S rRNA interface [nucleotide binding]; other site 452471001455 CTC domain interface [polypeptide binding]; other site 452471001456 L16 interface [polypeptide binding]; other site 452471001457 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 452471001458 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 452471001459 Ligand binding site; other site 452471001460 Putative Catalytic site; other site 452471001461 DXD motif; other site 452471001462 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 452471001463 active site 452471001464 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 452471001465 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 452471001466 Integrase core domain; Region: rve; pfam00665 452471001467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471001468 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471001469 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 452471001470 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 452471001471 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471001472 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471001473 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471001474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 452471001475 TPR motif; other site 452471001476 binding surface 452471001477 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 452471001478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471001479 TPR motif; other site 452471001480 binding surface 452471001481 TPR repeat; Region: TPR_11; pfam13414 452471001482 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 452471001483 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 452471001484 tetramer interface [polypeptide binding]; other site 452471001485 TPP-binding site [chemical binding]; other site 452471001486 heterodimer interface [polypeptide binding]; other site 452471001487 phosphorylation loop region [posttranslational modification] 452471001488 recombination protein F; Reviewed; Region: recF; PRK00064 452471001489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452471001490 Walker A/P-loop; other site 452471001491 ATP binding site [chemical binding]; other site 452471001492 Q-loop/lid; other site 452471001493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452471001494 ABC transporter signature motif; other site 452471001495 Walker B; other site 452471001496 D-loop; other site 452471001497 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 452471001498 NACHT domain; Region: NACHT; pfam05729 452471001499 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001500 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001501 Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685 452471001502 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 452471001503 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 452471001504 HIGH motif; other site 452471001505 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 452471001506 active site 452471001507 KMSKS motif; other site 452471001508 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452471001509 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452471001510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452471001511 Walker A/P-loop; other site 452471001512 ATP binding site [chemical binding]; other site 452471001513 Q-loop/lid; other site 452471001514 ABC transporter signature motif; other site 452471001515 Walker B; other site 452471001516 D-loop; other site 452471001517 H-loop/switch region; other site 452471001518 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 452471001519 MgtE intracellular N domain; Region: MgtE_N; smart00924 452471001520 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 452471001521 Divalent cation transporter; Region: MgtE; pfam01769 452471001522 Tumour suppressor, Mitostatin; Region: Trichoplein; pfam13868 452471001523 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001524 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471001525 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001526 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001527 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001528 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001529 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471001530 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001531 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001532 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 452471001533 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471001534 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001535 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001536 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001537 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001538 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001539 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001540 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001541 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001542 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001543 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471001544 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001545 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001546 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001547 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001548 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001549 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001550 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001551 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471001552 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001553 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001554 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001555 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001556 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001557 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001558 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471001559 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001560 Ankyrin repeat; Region: Ank; pfam00023 452471001561 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001562 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001563 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001564 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001565 SecA DEAD-like domain; Region: SecA_DEAD; pfam07517 452471001566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452471001567 ATP binding site [chemical binding]; other site 452471001568 putative Mg++ binding site [ion binding]; other site 452471001569 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452471001570 nucleotide binding region [chemical binding]; other site 452471001571 ATP-binding site [chemical binding]; other site 452471001572 TPR repeat; Region: TPR_11; pfam13414 452471001573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471001574 binding surface 452471001575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471001576 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471001577 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001578 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001579 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001580 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001581 Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]; Region: COG5098 452471001582 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 452471001583 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452471001584 FeS/SAM binding site; other site 452471001585 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 452471001586 ligand binding site [chemical binding]; other site 452471001587 primosomal protein N' Region: priA; TIGR00595 452471001588 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452471001589 ATP binding site [chemical binding]; other site 452471001590 putative Mg++ binding site [ion binding]; other site 452471001591 helicase superfamily c-terminal domain; Region: HELICc; smart00490 452471001592 ATP-binding site [chemical binding]; other site 452471001593 potential protein location (hypothetical protein Aasi_1618 [Candidatus Amoebophilus asiaticus 5a2]) that overlaps RNA (tRNA-P) 452471001594 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471001595 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471001596 Leucine-rich repeats; other site 452471001597 Substrate binding site [chemical binding]; other site 452471001598 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 452471001599 DNA-binding interface [nucleotide binding]; DNA binding site 452471001600 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452471001601 dimerization interface [polypeptide binding]; other site 452471001602 putative DNA binding site [nucleotide binding]; other site 452471001603 putative Zn2+ binding site [ion binding]; other site 452471001604 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 452471001605 hydrophobic ligand binding site; other site 452471001606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 452471001607 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 452471001608 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 452471001609 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 452471001610 Predicted flavoprotein [General function prediction only]; Region: COG0431 452471001611 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452471001612 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 452471001613 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 452471001614 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 452471001615 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 452471001616 dimer interface [polypeptide binding]; other site 452471001617 putative radical transfer pathway; other site 452471001618 diiron center [ion binding]; other site 452471001619 tyrosyl radical; other site 452471001620 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 452471001621 ATP cone domain; Region: ATP-cone; pfam03477 452471001622 Class I ribonucleotide reductase; Region: RNR_I; cd01679 452471001623 active site 452471001624 dimer interface [polypeptide binding]; other site 452471001625 catalytic residues [active] 452471001626 effector binding site; other site 452471001627 R2 peptide binding site; other site 452471001628 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471001629 F-box-like; Region: F-box-like; pfam12937 452471001630 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 452471001631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 452471001632 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471001633 Sel1-like repeats; Region: SEL1; smart00671 452471001634 Sel1-like repeats; Region: SEL1; smart00671 452471001635 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471001636 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 452471001637 Leucine rich repeat; Region: LRR_8; pfam13855 452471001638 F-box domain; Region: F-box; pfam00646 452471001639 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471001640 Leucine-rich repeats; other site 452471001641 Substrate binding site [chemical binding]; other site 452471001642 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471001643 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471001644 Sel1-like repeats; Region: SEL1; smart00671 452471001645 Sel1 repeat; Region: Sel1; pfam08238 452471001646 Sel1-like repeats; Region: SEL1; smart00671 452471001647 Sel1-like repeats; Region: SEL1; smart00671 452471001648 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 452471001649 multiple promoter invertase; Provisional; Region: mpi; PRK13413 452471001650 catalytic residues [active] 452471001651 catalytic nucleophile [active] 452471001652 Presynaptic Site I dimer interface [polypeptide binding]; other site 452471001653 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 452471001654 Synaptic Flat tetramer interface [polypeptide binding]; other site 452471001655 Synaptic Site I dimer interface [polypeptide binding]; other site 452471001656 DNA binding site [nucleotide binding] 452471001657 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 452471001658 DNA-binding interface [nucleotide binding]; DNA binding site 452471001659 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452471001660 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452471001661 active site 452471001662 ATP binding site [chemical binding]; other site 452471001663 substrate binding site [chemical binding]; other site 452471001664 activation loop (A-loop); other site 452471001665 AAA ATPase domain; Region: AAA_16; pfam13191 452471001666 Predicted ATPase [General function prediction only]; Region: COG3899 452471001667 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452471001668 GAF domain; Region: GAF; pfam01590 452471001669 PAS fold; Region: PAS_3; pfam08447 452471001670 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452471001671 putative active site [active] 452471001672 heme pocket [chemical binding]; other site 452471001673 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452471001674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452471001675 dimer interface [polypeptide binding]; other site 452471001676 phosphorylation site [posttranslational modification] 452471001677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452471001678 ATP binding site [chemical binding]; other site 452471001679 Mg2+ binding site [ion binding]; other site 452471001680 G-X-G motif; other site 452471001681 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452471001682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452471001683 active site 452471001684 phosphorylation site [posttranslational modification] 452471001685 intermolecular recognition site; other site 452471001686 dimerization interface [polypeptide binding]; other site 452471001687 Integrase core domain; Region: rve_3; cl15866 452471001688 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471001689 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471001690 Winged helix-turn helix; Region: HTH_29; pfam13551 452471001691 Integrase core domain; Region: rve; pfam00665 452471001692 Integrase core domain; Region: rve_3; pfam13683 452471001693 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 452471001694 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 452471001695 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 452471001696 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 452471001697 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 452471001698 active site 452471001699 dimer interface [polypeptide binding]; other site 452471001700 motif 1; other site 452471001701 motif 2; other site 452471001702 motif 3; other site 452471001703 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 452471001704 anticodon binding site; other site 452471001705 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 452471001706 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 452471001707 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 452471001708 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 452471001709 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 452471001710 23S rRNA binding site [nucleotide binding]; other site 452471001711 L21 binding site [polypeptide binding]; other site 452471001712 L13 binding site [polypeptide binding]; other site 452471001713 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471001714 Na binding site [ion binding]; other site 452471001715 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452471001716 Zn2+ binding site [ion binding]; other site 452471001717 Mg2+ binding site [ion binding]; other site 452471001718 PhoH-like protein; Region: PhoH; pfam02562 452471001719 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 452471001720 N-acetyl-D-glucosamine binding site [chemical binding]; other site 452471001721 catalytic residue [active] 452471001722 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452471001723 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 452471001724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452471001725 S-adenosylmethionine binding site [chemical binding]; other site 452471001726 hypothetical protein; Provisional; Region: PRK11820 452471001727 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 452471001728 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 452471001729 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 452471001730 active site 452471001731 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 452471001732 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 452471001733 ribosomal protein L33; Region: rpl33; CHL00104 452471001734 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 452471001735 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 452471001736 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 452471001737 P loop; other site 452471001738 GTP binding site [chemical binding]; other site 452471001739 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471001740 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001741 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001742 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001743 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001744 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001745 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001746 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471001747 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471001748 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 452471001749 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 452471001750 GatB domain; Region: GatB_Yqey; smart00845 452471001751 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 452471001752 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 452471001753 motif 1; other site 452471001754 active site 452471001755 motif 2; other site 452471001756 motif 3; other site 452471001757 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 452471001758 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 452471001759 Peptidase family M23; Region: Peptidase_M23; pfam01551 452471001760 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452471001761 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452471001762 DNA binding residues [nucleotide binding] 452471001763 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 452471001764 EamA-like transporter family; Region: EamA; pfam00892 452471001765 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 452471001766 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 452471001767 putative SAM binding site [chemical binding]; other site 452471001768 homodimer interface [polypeptide binding]; other site 452471001769 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471001770 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471001771 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 452471001772 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 452471001773 active site 452471001774 HIGH motif; other site 452471001775 dimer interface [polypeptide binding]; other site 452471001776 KMSKS motif; other site 452471001777 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 452471001778 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 452471001779 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 452471001780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471001781 Walker A motif; other site 452471001782 ATP binding site [chemical binding]; other site 452471001783 Walker B motif; other site 452471001784 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 452471001785 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 452471001786 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 452471001787 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 452471001788 oligomer interface [polypeptide binding]; other site 452471001789 active site 452471001790 metal binding site [ion binding]; metal-binding site 452471001791 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 452471001792 RimM N-terminal domain; Region: RimM; pfam01782 452471001793 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 452471001794 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 452471001795 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452471001796 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 452471001797 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 452471001798 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 452471001799 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 452471001800 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 452471001801 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 452471001802 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 452471001803 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452471001804 active site 452471001805 HIGH motif; other site 452471001806 nucleotide binding site [chemical binding]; other site 452471001807 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 452471001808 KMSK motif region; other site 452471001809 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 452471001810 tRNA binding surface [nucleotide binding]; other site 452471001811 anticodon binding site; other site 452471001812 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452471001813 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 452471001814 DHH family; Region: DHH; pfam01368 452471001815 DHHA1 domain; Region: DHHA1; pfam02272 452471001816 Preprotein translocase SecG subunit; Region: SecG; pfam03840 452471001817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471001818 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 452471001819 Walker A motif; other site 452471001820 ATP binding site [chemical binding]; other site 452471001821 Walker B motif; other site 452471001822 arginine finger; other site 452471001823 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 452471001824 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 452471001825 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 452471001826 putative active site [active] 452471001827 AAA domain; Region: AAA_21; pfam13304 452471001828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 452471001829 Q-loop/lid; other site 452471001830 ABC transporter signature motif; other site 452471001831 Walker B; other site 452471001832 D-loop; other site 452471001833 H-loop/switch region; other site 452471001834 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471001835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471001836 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471001837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 452471001838 Integrase core domain; Region: rve; pfam00665 452471001839 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 452471001840 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 452471001841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452471001842 FeS/SAM binding site; other site 452471001843 TRAM domain; Region: TRAM; pfam01938 452471001844 Domain of unknown function (DUF368); Region: DUF368; pfam04018 452471001845 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471001846 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471001847 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 452471001848 G1 box; other site 452471001849 GTP/Mg2+ binding site [chemical binding]; other site 452471001850 Switch I region; other site 452471001851 G2 box; other site 452471001852 G3 box; other site 452471001853 Switch II region; other site 452471001854 G4 box; other site 452471001855 G5 box; other site 452471001856 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 452471001857 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452471001858 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452471001859 protein binding site [polypeptide binding]; other site 452471001860 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452471001861 protein binding site [polypeptide binding]; other site 452471001862 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 452471001863 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 452471001864 active site 452471001865 HIGH motif; other site 452471001866 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 452471001867 KMSKS motif; other site 452471001868 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 452471001869 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 452471001870 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 452471001871 minor groove reading motif; other site 452471001872 helix-hairpin-helix signature motif; other site 452471001873 substrate binding pocket [chemical binding]; other site 452471001874 active site 452471001875 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 452471001876 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 452471001877 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 452471001878 hypothetical protein; Validated; Region: PRK00110 452471001879 recombination protein RecR; Reviewed; Region: recR; PRK00076 452471001880 RecR protein; Region: RecR; pfam02132 452471001881 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 452471001882 putative active site [active] 452471001883 putative metal-binding site [ion binding]; other site 452471001884 tetramer interface [polypeptide binding]; other site 452471001885 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 452471001886 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 452471001887 ABC-ATPase subunit interface; other site 452471001888 dimer interface [polypeptide binding]; other site 452471001889 putative PBP binding regions; other site 452471001890 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 452471001891 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 452471001892 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 452471001893 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 452471001894 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471001895 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 452471001896 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 452471001897 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 452471001898 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 452471001899 DNA polymerase III subunit delta'; Validated; Region: PRK08485 452471001900 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 452471001901 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 452471001902 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 452471001903 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 452471001904 putative trimer interface [polypeptide binding]; other site 452471001905 putative CoA binding site [chemical binding]; other site 452471001906 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001907 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001908 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001909 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001910 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001911 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001912 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001913 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001914 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471001915 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471001916 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 452471001917 DNA-binding site [nucleotide binding]; DNA binding site 452471001918 RNA-binding motif; other site 452471001919 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 452471001920 mce related protein; Region: MCE; pfam02470 452471001921 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 452471001922 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 452471001923 active site 452471001924 metal binding site [ion binding]; metal-binding site 452471001925 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 452471001926 Mechanosensitive ion channel; Region: MS_channel; pfam00924 452471001927 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 452471001928 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 452471001929 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 452471001930 E3 interaction surface; other site 452471001931 lipoyl attachment site [posttranslational modification]; other site 452471001932 e3 binding domain; Region: E3_binding; pfam02817 452471001933 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 452471001934 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 452471001935 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 452471001936 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 452471001937 RNA binding site [nucleotide binding]; other site 452471001938 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 452471001939 RNA binding site [nucleotide binding]; other site 452471001940 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 452471001941 RNA binding site [nucleotide binding]; other site 452471001942 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 452471001943 RNA binding site [nucleotide binding]; other site 452471001944 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 452471001945 RNA binding site [nucleotide binding]; other site 452471001946 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 452471001947 Protein of unknown function (DUF721); Region: DUF721; pfam05258 452471001948 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 452471001949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 452471001950 ATP binding site [chemical binding]; other site 452471001951 Mg2+ binding site [ion binding]; other site 452471001952 G-X-G motif; other site 452471001953 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 452471001954 anchoring element; other site 452471001955 dimer interface [polypeptide binding]; other site 452471001956 ATP binding site [chemical binding]; other site 452471001957 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 452471001958 active site 452471001959 putative metal-binding site [ion binding]; other site 452471001960 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 452471001961 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 452471001962 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452471001963 catalytic residues [active] 452471001964 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 452471001965 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 452471001966 active site 452471001967 PHP Thumb interface [polypeptide binding]; other site 452471001968 metal binding site [ion binding]; metal-binding site 452471001969 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 452471001970 generic binding surface II; other site 452471001971 generic binding surface I; other site 452471001972 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 452471001973 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 452471001974 alpha subunit interface [polypeptide binding]; other site 452471001975 TPP binding site [chemical binding]; other site 452471001976 heterodimer interface [polypeptide binding]; other site 452471001977 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 452471001978 TIGR00159 family protein; Region: TIGR00159 452471001979 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 452471001980 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 452471001981 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 452471001982 cellulose synthase A [UDP-forming], catalytic subunit; Region: PLN02915 452471001983 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 452471001984 tandem repeat interface [polypeptide binding]; other site 452471001985 oligomer interface [polypeptide binding]; other site 452471001986 active site residues [active] 452471001987 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 452471001988 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 452471001989 tandem repeat interface [polypeptide binding]; other site 452471001990 oligomer interface [polypeptide binding]; other site 452471001991 active site residues [active] 452471001992 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 452471001993 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 452471001994 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 452471001995 Surface antigen; Region: Bac_surface_Ag; pfam01103 452471001996 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 452471001997 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 452471001998 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 452471001999 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452471002000 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 452471002001 dimerization interface [polypeptide binding]; other site 452471002002 putative DNA binding site [nucleotide binding]; other site 452471002003 putative Zn2+ binding site [ion binding]; other site 452471002004 AsnC family; Region: AsnC_trans_reg; pfam01037 452471002005 Protein of unknown function (DUF1284); Region: DUF1284; pfam06935 452471002006 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 452471002007 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 452471002008 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 452471002009 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 452471002010 RNA binding surface [nucleotide binding]; other site 452471002011 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 452471002012 active site 452471002013 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471002014 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471002015 Rhomboid family; Region: Rhomboid; cl11446 452471002016 Putative catalytic NodB homology domain of uncharacterized protein RC0012 from Rickettsia conorii and its bacterial homologs; Region: CE4_RC0012_like; cd10963 452471002017 NodB motif; other site 452471002018 putative active site [active] 452471002019 potential frameshift: common BLAST hit: gi|256419531|ref|YP_003120184.1| protein of unknown function DUF255 452471002020 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 452471002021 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452471002022 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 452471002023 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452471002024 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452471002025 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452471002026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452471002027 Walker A/P-loop; other site 452471002028 ATP binding site [chemical binding]; other site 452471002029 Q-loop/lid; other site 452471002030 ABC transporter signature motif; other site 452471002031 Walker B; other site 452471002032 D-loop; other site 452471002033 H-loop/switch region; other site 452471002034 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 452471002035 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 452471002036 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471002037 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 452471002038 Peptidase family M23; Region: Peptidase_M23; pfam01551 452471002039 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 452471002040 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 452471002041 Protein required for attachment to host cells; Region: Host_attach; pfam10116 452471002042 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471002043 Na binding site [ion binding]; other site 452471002044 Uncharacterized conserved protein [Function unknown]; Region: COG3189 452471002045 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471002046 Na binding site [ion binding]; other site 452471002047 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 452471002048 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452471002049 Zn2+ binding site [ion binding]; other site 452471002050 Mg2+ binding site [ion binding]; other site 452471002051 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 452471002052 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 452471002053 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 452471002054 Mechanosensitive ion channel; Region: MS_channel; pfam00924 452471002055 hypothetical protein; Reviewed; Region: PRK12497 452471002056 peptide chain release factor 1; Validated; Region: prfA; PRK00591 452471002057 This domain is found in peptide chain release factors; Region: PCRF; smart00937 452471002058 RF-1 domain; Region: RF-1; pfam00472 452471002059 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002060 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002061 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471002062 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002063 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002064 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002065 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002066 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002067 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002068 Ankyrin repeat; Region: Ank; pfam00023 452471002069 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002070 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002071 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002072 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471002073 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471002074 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471002075 Recombination protein O N terminal; Region: RecO_N; pfam11967 452471002076 DNA repair protein RecO; Region: reco; TIGR00613 452471002077 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 452471002078 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 452471002079 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 452471002080 active site 452471002081 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 452471002082 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 452471002083 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 452471002084 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 452471002085 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 452471002086 dimer interface [polypeptide binding]; other site 452471002087 active site 452471002088 CoA binding pocket [chemical binding]; other site 452471002089 elongation factor P; Validated; Region: PRK00529 452471002090 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 452471002091 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 452471002092 RNA binding site [nucleotide binding]; other site 452471002093 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 452471002094 RNA binding site [nucleotide binding]; other site 452471002095 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 452471002096 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 452471002097 carboxyltransferase (CT) interaction site; other site 452471002098 biotinylation site [posttranslational modification]; other site 452471002099 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 452471002100 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 452471002101 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452471002102 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 452471002103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002104 TPR motif; other site 452471002105 binding surface 452471002106 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002107 F-box-like; Region: F-box-like; cl02535 452471002108 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471002109 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 452471002110 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002111 Sel1 repeat; Region: Sel1; pfam08238 452471002112 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002114 TPR motif; other site 452471002115 binding surface 452471002116 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471002117 Leucine-rich repeats; other site 452471002118 Substrate binding site [chemical binding]; other site 452471002119 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 452471002120 Smr domain; Region: Smr; pfam01713 452471002121 Sel1-like repeats; Region: SEL1; smart00671 452471002122 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002123 Sel1-like repeats; Region: SEL1; smart00671 452471002124 Sel1-like repeats; Region: SEL1; smart00671 452471002125 Sel1-like repeats; Region: SEL1; smart00671 452471002126 Sel1-like repeats; Region: SEL1; smart00671 452471002127 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002128 Sel1-like repeats; Region: SEL1; smart00671 452471002129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002130 binding surface 452471002131 TPR motif; other site 452471002132 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002133 Sel1 repeat; Region: Sel1; pfam08238 452471002134 Sel1-like repeats; Region: SEL1; smart00671 452471002135 Class I aldolases; Region: Aldolase_Class_I; cl17187 452471002136 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471002137 Leucine-rich repeats; other site 452471002138 Substrate binding site [chemical binding]; other site 452471002139 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 452471002140 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 452471002141 G1 box; other site 452471002142 putative GEF interaction site [polypeptide binding]; other site 452471002143 GTP/Mg2+ binding site [chemical binding]; other site 452471002144 Switch I region; other site 452471002145 G2 box; other site 452471002146 G3 box; other site 452471002147 Switch II region; other site 452471002148 G4 box; other site 452471002149 G5 box; other site 452471002150 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 452471002151 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 452471002152 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452471002153 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452471002154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452471002155 Walker A/P-loop; other site 452471002156 ATP binding site [chemical binding]; other site 452471002157 Q-loop/lid; other site 452471002158 ABC transporter signature motif; other site 452471002159 Walker B; other site 452471002160 D-loop; other site 452471002161 H-loop/switch region; other site 452471002162 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 452471002163 nucleotide binding site/active site [active] 452471002164 HIT family signature motif; other site 452471002165 catalytic residue [active] 452471002166 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 452471002167 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 452471002168 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 452471002169 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 452471002170 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 452471002171 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 452471002172 Phosphoglycerate kinase; Region: PGK; pfam00162 452471002173 substrate binding site [chemical binding]; other site 452471002174 hinge regions; other site 452471002175 ADP binding site [chemical binding]; other site 452471002176 catalytic site [active] 452471002177 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002178 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002179 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002180 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002181 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002182 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002183 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002184 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002185 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002186 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002187 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471002188 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002189 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002190 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002191 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002192 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002193 AAA domain; Region: AAA_14; pfam13173 452471002194 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 452471002195 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 452471002196 putative active site [active] 452471002197 catalytic residue [active] 452471002198 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 452471002199 putative dimer interface [polypeptide binding]; other site 452471002200 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452471002201 Helix-turn-helix domain; Region: HTH_18; pfam12833 452471002202 potassium/proton antiporter; Reviewed; Region: PRK05326 452471002203 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 452471002204 TrkA-C domain; Region: TrkA_C; pfam02080 452471002205 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 452471002206 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 452471002207 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 452471002208 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 452471002209 active site 452471002210 Zn binding site [ion binding]; other site 452471002211 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 452471002212 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 452471002213 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452471002214 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452471002215 Walker A/P-loop; other site 452471002216 ATP binding site [chemical binding]; other site 452471002217 Q-loop/lid; other site 452471002218 ABC transporter signature motif; other site 452471002219 Walker B; other site 452471002220 D-loop; other site 452471002221 H-loop/switch region; other site 452471002222 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 452471002223 EamA-like transporter family; Region: EamA; pfam00892 452471002224 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 452471002225 nucleophilic elbow; other site 452471002226 catalytic triad; other site 452471002227 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002228 Sel1-like repeats; Region: SEL1; smart00671 452471002229 Sel1-like repeats; Region: SEL1; smart00671 452471002230 Sel1-like repeats; Region: SEL1; smart00671 452471002231 Sel1-like repeats; Region: SEL1; smart00671 452471002232 Sel1-like repeats; Region: SEL1; smart00671 452471002233 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 452471002234 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 452471002235 MutS domain I; Region: MutS_I; pfam01624 452471002236 MutS domain II; Region: MutS_II; pfam05188 452471002237 MutS domain III; Region: MutS_III; pfam05192 452471002238 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 452471002239 Walker A/P-loop; other site 452471002240 ATP binding site [chemical binding]; other site 452471002241 Q-loop/lid; other site 452471002242 ABC transporter signature motif; other site 452471002243 Walker B; other site 452471002244 D-loop; other site 452471002245 H-loop/switch region; other site 452471002246 M28 Zn-Peptidases; Region: M28_like_6; cd08656 452471002247 Peptidase family M28; Region: Peptidase_M28; pfam04389 452471002248 metal binding site [ion binding]; metal-binding site 452471002249 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 452471002250 active site 452471002251 putative DNA-binding cleft [nucleotide binding]; other site 452471002252 dimer interface [polypeptide binding]; other site 452471002253 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cd02257 452471002254 Ubiquitin carboxyl-terminal hydrolase; Region: UCH; pfam00443 452471002255 active site 452471002256 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471002257 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 452471002258 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 452471002259 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 452471002260 active site 452471002261 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 452471002262 EamA-like transporter family; Region: EamA; pfam00892 452471002263 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 452471002264 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 452471002265 substrate binding pocket [chemical binding]; other site 452471002266 chain length determination region; other site 452471002267 substrate-Mg2+ binding site; other site 452471002268 catalytic residues [active] 452471002269 aspartate-rich region 1; other site 452471002270 active site lid residues [active] 452471002271 aspartate-rich region 2; other site 452471002272 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 452471002273 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 452471002274 putative dimer interface [polypeptide binding]; other site 452471002275 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 452471002276 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 452471002277 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 452471002278 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 452471002279 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 452471002280 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 452471002281 catalytic residue [active] 452471002282 putative FPP diphosphate binding site; other site 452471002283 putative FPP binding hydrophobic cleft; other site 452471002284 dimer interface [polypeptide binding]; other site 452471002285 putative IPP diphosphate binding site; other site 452471002286 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 452471002287 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 452471002288 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 452471002289 Surface antigen; Region: Bac_surface_Ag; pfam01103 452471002290 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 452471002291 SurA N-terminal domain; Region: SurA_N_3; cl07813 452471002292 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 452471002293 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 452471002294 potential frameshift: common BLAST hit: gi|189502176|ref|YP_001957893.1| transposase IS4 family protein 452471002295 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471002296 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471002297 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 452471002298 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 452471002299 putative dimer interface [polypeptide binding]; other site 452471002300 putative anticodon binding site; other site 452471002301 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 452471002302 homodimer interface [polypeptide binding]; other site 452471002303 motif 1; other site 452471002304 motif 2; other site 452471002305 active site 452471002306 motif 3; other site 452471002307 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 452471002308 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 452471002309 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 452471002310 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 452471002311 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 452471002312 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 452471002313 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 452471002314 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 452471002315 NAD(P) binding site [chemical binding]; other site 452471002316 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 452471002317 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 452471002318 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 452471002319 amidase catalytic site [active] 452471002320 Zn binding residues [ion binding]; other site 452471002321 substrate binding site [chemical binding]; other site 452471002322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471002323 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471002324 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 452471002325 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 452471002326 acyl-activating enzyme (AAE) consensus motif; other site 452471002327 putative AMP binding site [chemical binding]; other site 452471002328 putative active site [active] 452471002329 putative CoA binding site [chemical binding]; other site 452471002330 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471002331 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452471002332 F-box-like; Region: F-box-like; pfam12937 452471002333 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 452471002334 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 452471002335 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 452471002336 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 452471002337 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 452471002338 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 452471002339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452471002340 nucleotide binding region [chemical binding]; other site 452471002341 ATP-binding site [chemical binding]; other site 452471002342 gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530 452471002343 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 452471002344 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 452471002345 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 452471002346 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 452471002347 DNA photolyase; Region: DNA_photolyase; pfam00875 452471002348 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 452471002349 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 452471002350 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 452471002351 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452471002352 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 452471002353 CAAX protease self-immunity; Region: Abi; pfam02517 452471002354 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 452471002355 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 452471002356 FMN binding site [chemical binding]; other site 452471002357 active site 452471002358 catalytic residues [active] 452471002359 substrate binding site [chemical binding]; other site 452471002360 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471002361 Protein kinase domain; Region: Pkinase; pfam00069 452471002362 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452471002363 active site 452471002364 ATP binding site [chemical binding]; other site 452471002365 substrate binding site [chemical binding]; other site 452471002366 activation loop (A-loop); other site 452471002367 NB-ARC domain; Region: NB-ARC; pfam00931 452471002368 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002369 TPR motif; other site 452471002370 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471002371 binding surface 452471002372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002373 binding surface 452471002374 TPR motif; other site 452471002375 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471002376 potential frameshift: common BLAST hit: gi|189502533|ref|YP_001958250.1| transposase IS4 family protein 452471002377 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471002378 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471002379 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452471002380 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471002381 Tetratricopeptide repeat; Region: TPR_10; pfam13374 452471002382 Colicin V production protein; Region: Colicin_V; pfam02674 452471002383 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452471002384 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 452471002385 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 452471002386 CAP-like domain; other site 452471002387 active site 452471002388 primary dimer interface [polypeptide binding]; other site 452471002389 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 452471002390 DNA gyrase subunit A; Validated; Region: PRK05560 452471002391 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 452471002392 CAP-like domain; other site 452471002393 active site 452471002394 primary dimer interface [polypeptide binding]; other site 452471002395 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452471002396 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452471002397 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452471002398 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452471002399 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452471002400 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452471002401 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 452471002402 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471002403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 452471002404 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 452471002405 Predicted transcriptional regulator [Transcription]; Region: COG2378 452471002406 HTH domain; Region: HTH_11; pfam08279 452471002407 WYL domain; Region: WYL; pfam13280 452471002408 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471002409 Na binding site [ion binding]; other site 452471002410 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 452471002411 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452471002412 Zn2+ binding site [ion binding]; other site 452471002413 Mg2+ binding site [ion binding]; other site 452471002414 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 452471002415 RNA/DNA hybrid binding site [nucleotide binding]; other site 452471002416 active site 452471002417 Modified RING finger domain; Region: Ubox; smart00504 452471002418 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002419 Sel1-like repeats; Region: SEL1; smart00671 452471002420 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002421 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002422 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002423 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002424 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471002425 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002426 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002427 Modified RING finger domain; Region: Ubox; smart00504 452471002428 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002429 Sel1-like repeats; Region: SEL1; smart00671 452471002430 Sel1-like repeats; Region: SEL1; smart00671 452471002431 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002432 Sel1-like repeats; Region: SEL1; smart00671 452471002433 Sel1-like repeats; Region: SEL1; smart00671 452471002434 Sel1-like repeats; Region: SEL1; smart00671 452471002435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002436 binding surface 452471002437 TPR motif; other site 452471002438 Sel1-like repeats; Region: SEL1; smart00671 452471002439 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002441 TPR motif; other site 452471002442 binding surface 452471002443 Sel1-like repeats; Region: SEL1; smart00671 452471002444 Sel1-like repeats; Region: SEL1; smart00671 452471002445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002446 binding surface 452471002447 TPR motif; other site 452471002448 Sel1-like repeats; Region: SEL1; smart00671 452471002449 Modified RING finger domain; Region: Ubox; smart00504 452471002450 Sel1-like repeats; Region: SEL1; smart00671 452471002451 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002452 Sel1-like repeats; Region: SEL1; smart00671 452471002453 Sel1-like repeats; Region: SEL1; smart00671 452471002454 Sel1-like repeats; Region: SEL1; smart00671 452471002455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002456 binding surface 452471002457 TPR motif; other site 452471002458 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002459 Sel1-like repeats; Region: SEL1; smart00671 452471002460 Sel1-like repeats; Region: SEL1; smart00671 452471002461 Sel1-like repeats; Region: SEL1; smart00671 452471002462 Sel1-like repeats; Region: SEL1; smart00671 452471002463 Sel1-like repeats; Region: SEL1; smart00671 452471002464 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002465 Sel1-like repeats; Region: SEL1; smart00671 452471002466 Sel1-like repeats; Region: SEL1; smart00671 452471002467 Sel1-like repeats; Region: SEL1; smart00671 452471002468 Sel1-like repeats; Region: SEL1; smart00671 452471002469 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002470 Sel1-like repeats; Region: SEL1; smart00671 452471002471 Sel1-like repeats; Region: SEL1; smart00671 452471002472 Sel1-like repeats; Region: SEL1; smart00671 452471002473 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002474 Sel1-like repeats; Region: SEL1; smart00671 452471002475 Sel1-like repeats; Region: SEL1; smart00671 452471002476 Sel1-like repeats; Region: SEL1; smart00671 452471002477 Sel1-like repeats; Region: SEL1; smart00671 452471002478 Sel1-like repeats; Region: SEL1; smart00671 452471002479 Sel1-like repeats; Region: SEL1; smart00671 452471002480 Sel1-like repeats; Region: SEL1; smart00671 452471002481 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 452471002482 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452471002483 active site 452471002484 DNA binding site [nucleotide binding] 452471002485 Int/Topo IB signature motif; other site 452471002486 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 452471002487 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 452471002488 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452471002489 catalytic residue [active] 452471002490 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 452471002491 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 452471002492 GIY-YIG motif/motif A; other site 452471002493 active site 452471002494 catalytic site [active] 452471002495 putative DNA binding site [nucleotide binding]; other site 452471002496 metal binding site [ion binding]; metal-binding site 452471002497 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 452471002498 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 452471002499 DNA binding site [nucleotide binding] 452471002500 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 452471002501 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 452471002502 active site 452471002503 Zn binding site [ion binding]; other site 452471002504 Transposase IS200 like; Region: Y1_Tnp; pfam01797 452471002505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452471002506 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 452471002507 Walker A/P-loop; other site 452471002508 ATP binding site [chemical binding]; other site 452471002509 Q-loop/lid; other site 452471002510 ABC transporter signature motif; other site 452471002511 Walker B; other site 452471002512 D-loop; other site 452471002513 H-loop/switch region; other site 452471002514 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 452471002515 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 452471002516 ABC-2 type transporter; Region: ABC2_membrane; cl17235 452471002517 Domain of unknown function DUF59; Region: DUF59; pfam01883 452471002518 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 452471002519 Transposase IS200 like; Region: Y1_Tnp; pfam01797 452471002520 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002521 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 452471002522 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002523 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002524 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002525 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002526 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002527 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 452471002528 active site 452471002529 NTP binding site [chemical binding]; other site 452471002530 metal binding triad [ion binding]; metal-binding site 452471002531 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 452471002532 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452471002533 Zn2+ binding site [ion binding]; other site 452471002534 Mg2+ binding site [ion binding]; other site 452471002535 Toprim-like; Region: Toprim_2; pfam13155 452471002536 Transposase IS200 like; Region: Y1_Tnp; pfam01797 452471002537 Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782 452471002538 Domain of unknown function (DUF4138); Region: DUF4138; pfam13595 452471002539 Winged helix-turn helix; Region: HTH_29; pfam13551 452471002540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 452471002541 Integrase core domain; Region: rve; pfam00665 452471002542 Integrase core domain; Region: rve_3; pfam13683 452471002543 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471002544 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471002545 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 452471002546 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 452471002547 Transposase IS200 like; Region: Y1_Tnp; pfam01797 452471002548 Protein of unknown function (DUF3714); Region: DUF3714; pfam12508 452471002549 potential frameshift: common BLAST hit: gi|189502176|ref|YP_001957893.1| transposase IS4 family protein 452471002550 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471002551 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471002552 potential frameshift: common BLAST hit: gi|189501507|ref|YP_001957224.1| metal-dependent phosphohydrolase HD sub domain 452471002553 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471002554 Na binding site [ion binding]; other site 452471002555 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 452471002556 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452471002557 Zn2+ binding site [ion binding]; other site 452471002558 Mg2+ binding site [ion binding]; other site 452471002559 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002561 TPR motif; other site 452471002562 binding surface 452471002563 Sel1-like repeats; Region: SEL1; smart00671 452471002564 Sel1-like repeats; Region: SEL1; smart00671 452471002565 Sel1-like repeats; Region: SEL1; smart00671 452471002566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002567 binding surface 452471002568 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002569 TPR motif; other site 452471002570 Sel1 repeat; Region: Sel1; pfam08238 452471002571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002572 binding surface 452471002573 TPR motif; other site 452471002574 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 452471002575 putative transposase; Provisional; Region: PRK09857 452471002576 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 452471002577 Sel1-like repeats; Region: SEL1; smart00671 452471002578 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002579 Sel1-like repeats; Region: SEL1; smart00671 452471002580 Sel1-like repeats; Region: SEL1; smart00671 452471002581 Sel1-like repeats; Region: SEL1; smart00671 452471002582 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002584 TPR motif; other site 452471002585 binding surface 452471002586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002587 TPR motif; other site 452471002588 binding surface 452471002589 Sel1-like repeats; Region: SEL1; smart00671 452471002590 Sel1-like repeats; Region: SEL1; smart00671 452471002591 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002592 Sel1-like repeats; Region: SEL1; smart00671 452471002593 Sel1-like repeats; Region: SEL1; smart00671 452471002594 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 452471002595 putative active site [active] 452471002596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 452471002597 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 452471002598 Integrase core domain; Region: rve; pfam00665 452471002599 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 452471002600 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 452471002601 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 452471002602 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 452471002603 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452471002604 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 452471002605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452471002606 Walker A/P-loop; other site 452471002607 ATP binding site [chemical binding]; other site 452471002608 Q-loop/lid; other site 452471002609 ABC transporter signature motif; other site 452471002610 Walker B; other site 452471002611 D-loop; other site 452471002612 H-loop/switch region; other site 452471002613 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471002614 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 452471002615 Initiator Replication protein; Region: Rep_3; cl17676 452471002616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 452471002617 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 452471002618 Integrase core domain; Region: rve; pfam00665 452471002619 putative transposase OrfB; Reviewed; Region: PHA02517 452471002620 Integrase core domain; Region: rve; pfam00665 452471002621 Integrase core domain; Region: rve_3; pfam13683 452471002622 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 452471002623 MraW methylase family; Region: Methyltransf_5; cl17771 452471002624 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002625 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002626 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002627 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002628 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002629 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002630 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002631 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002632 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 452471002633 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002634 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002635 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002636 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002637 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471002638 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002639 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002640 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002641 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002642 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002643 DNA primase; Validated; Region: dnaG; PRK05667 452471002644 CHC2 zinc finger; Region: zf-CHC2; pfam01807 452471002645 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 452471002646 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 452471002647 active site 452471002648 metal binding site [ion binding]; metal-binding site 452471002649 interdomain interaction site; other site 452471002650 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 452471002651 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 452471002652 Part of AAA domain; Region: AAA_19; pfam13245 452471002653 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 452471002654 Family description; Region: UvrD_C_2; pfam13538 452471002655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471002656 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471002657 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 452471002658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452471002659 Walker A/P-loop; other site 452471002660 ATP binding site [chemical binding]; other site 452471002661 Q-loop/lid; other site 452471002662 ABC transporter signature motif; other site 452471002663 Walker B; other site 452471002664 D-loop; other site 452471002665 H-loop/switch region; other site 452471002666 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 452471002667 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 452471002668 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 452471002669 active site residue [active] 452471002670 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 452471002671 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 452471002672 putative trimer interface [polypeptide binding]; other site 452471002673 putative CoA binding site [chemical binding]; other site 452471002674 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002675 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002676 Sel1 repeat; Region: Sel1; pfam08238 452471002677 Sel1-like repeats; Region: SEL1; smart00671 452471002678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002679 binding surface 452471002680 TPR motif; other site 452471002681 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471002682 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471002683 Substrate binding site [chemical binding]; other site 452471002684 F-box-like; Region: F-box-like; cl02535 452471002685 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471002686 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 452471002687 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 452471002688 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 452471002689 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 452471002690 alpha subunit interaction interface [polypeptide binding]; other site 452471002691 Walker A motif; other site 452471002692 ATP binding site [chemical binding]; other site 452471002693 Walker B motif; other site 452471002694 inhibitor binding site; inhibition site 452471002695 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 452471002696 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 452471002697 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452471002698 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471002699 Na binding site [ion binding]; other site 452471002700 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 452471002701 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452471002702 Zn2+ binding site [ion binding]; other site 452471002703 Mg2+ binding site [ion binding]; other site 452471002704 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 452471002705 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 452471002706 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 452471002707 homodimer interface [polypeptide binding]; other site 452471002708 NADP binding site [chemical binding]; other site 452471002709 substrate binding site [chemical binding]; other site 452471002710 GTP-binding protein LepA; Provisional; Region: PRK05433 452471002711 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 452471002712 G1 box; other site 452471002713 putative GEF interaction site [polypeptide binding]; other site 452471002714 GTP/Mg2+ binding site [chemical binding]; other site 452471002715 Switch I region; other site 452471002716 G2 box; other site 452471002717 G3 box; other site 452471002718 Switch II region; other site 452471002719 G4 box; other site 452471002720 G5 box; other site 452471002721 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 452471002722 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 452471002723 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 452471002724 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 452471002725 Winged helix-turn helix; Region: HTH_29; pfam13551 452471002726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 452471002727 Integrase core domain; Region: rve; pfam00665 452471002728 Integrase core domain; Region: rve_3; pfam13683 452471002729 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471002730 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471002731 Na binding site [ion binding]; other site 452471002732 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 452471002733 HD domain; Region: HD_4; pfam13328 452471002734 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471002735 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452471002736 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 452471002737 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 452471002738 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 452471002739 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 452471002740 heat shock protein 90; Provisional; Region: PRK05218 452471002741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452471002742 Mg2+ binding site [ion binding]; other site 452471002743 G-X-G motif; other site 452471002744 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002745 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002746 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002747 F-box-like; Region: F-box-like; pfam12937 452471002748 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 452471002749 CoenzymeA binding site [chemical binding]; other site 452471002750 subunit interaction site [polypeptide binding]; other site 452471002751 PHB binding site; other site 452471002752 replicative DNA helicase; Region: DnaB; TIGR00665 452471002753 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 452471002754 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 452471002755 Walker A motif; other site 452471002756 ATP binding site [chemical binding]; other site 452471002757 Walker B motif; other site 452471002758 DNA binding loops [nucleotide binding] 452471002759 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002760 Sel1-like repeats; Region: SEL1; smart00671 452471002761 Sel1-like repeats; Region: SEL1; smart00671 452471002762 Sel1-like repeats; Region: SEL1; smart00671 452471002763 Sel1-like repeats; Region: SEL1; smart00671 452471002764 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002765 Sel1 repeat; Region: Sel1; pfam08238 452471002766 Sel1-like repeats; Region: SEL1; smart00671 452471002767 Sel1-like repeats; Region: SEL1; smart00671 452471002768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002769 binding surface 452471002770 TPR motif; other site 452471002771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002772 binding surface 452471002773 TPR motif; other site 452471002774 Winged helix-turn helix; Region: HTH_29; pfam13551 452471002775 Integrase core domain; Region: rve; pfam00665 452471002776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 452471002777 Integrase core domain; Region: rve_3; pfam13683 452471002778 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002780 binding surface 452471002781 TPR motif; other site 452471002782 Sel1-like repeats; Region: SEL1; smart00671 452471002783 Sel1-like repeats; Region: SEL1; smart00671 452471002784 Sel1-like repeats; Region: SEL1; smart00671 452471002785 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002786 Sel1-like repeats; Region: SEL1; smart00671 452471002787 Sel1-like repeats; Region: SEL1; smart00671 452471002788 Winged helix-turn helix; Region: HTH_29; pfam13551 452471002789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 452471002790 Integrase core domain; Region: rve; pfam00665 452471002791 Integrase core domain; Region: rve_3; pfam13683 452471002792 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452471002793 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452471002794 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 452471002795 Walker A/P-loop; other site 452471002796 ATP binding site [chemical binding]; other site 452471002797 Q-loop/lid; other site 452471002798 ABC transporter signature motif; other site 452471002799 Walker B; other site 452471002800 D-loop; other site 452471002801 H-loop/switch region; other site 452471002802 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 452471002803 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452471002804 Transposase domain (DUF772); Region: DUF772; pfam05598 452471002805 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471002806 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 452471002807 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 452471002808 active site 452471002809 nucleophile elbow; other site 452471002810 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 452471002811 nucleophilic elbow; other site 452471002812 catalytic triad; other site 452471002813 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471002814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002815 TPR motif; other site 452471002816 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471002817 binding surface 452471002818 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471002819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002820 binding surface 452471002821 TPR motif; other site 452471002822 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471002823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002824 binding surface 452471002825 TPR motif; other site 452471002826 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471002827 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471002828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002829 binding surface 452471002830 TPR motif; other site 452471002831 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471002832 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471002833 Tetratricopeptide repeat; Region: TPR_7; pfam13176 452471002834 Sel1-like repeats; Region: SEL1; smart00671 452471002835 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002836 Sel1-like repeats; Region: SEL1; smart00671 452471002837 Sel1-like repeats; Region: SEL1; smart00671 452471002838 Sel1-like repeats; Region: SEL1; smart00671 452471002839 Sel1-like repeats; Region: SEL1; smart00671 452471002840 Sel1-like repeats; Region: SEL1; smart00671 452471002841 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471002842 Sel1-like repeats; Region: SEL1; smart00671 452471002843 Sel1-like repeats; Region: SEL1; smart00671 452471002844 Sel1-like repeats; Region: SEL1; smart00671 452471002845 Sel1-like repeats; Region: SEL1; smart00671 452471002846 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 452471002847 nucleophilic elbow; other site 452471002848 catalytic triad; other site 452471002849 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 452471002850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002851 binding surface 452471002852 TPR motif; other site 452471002853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002854 binding surface 452471002855 TPR motif; other site 452471002856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002857 binding surface 452471002858 TPR motif; other site 452471002859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002860 binding surface 452471002861 TPR motif; other site 452471002862 Tetratricopeptide repeat; Region: TPR_10; pfam13374 452471002863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002864 binding surface 452471002865 TPR motif; other site 452471002866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002867 binding surface 452471002868 TPR motif; other site 452471002869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002870 binding surface 452471002871 TPR motif; other site 452471002872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002873 binding surface 452471002874 TPR motif; other site 452471002875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471002876 binding surface 452471002877 TPR motif; other site 452471002878 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471002879 Tetratricopeptide repeat; Region: TPR_10; pfam13374 452471002880 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 452471002881 active site 452471002882 nucleophile elbow; other site 452471002883 Orientia OTT_1508-like deaminase; Region: OTT_1508_deam; pfam14441 452471002884 Transposase IS200 like; Region: Y1_Tnp; pfam01797 452471002885 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471002886 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 452471002887 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 452471002888 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 452471002889 Protein of unknown function DUF72; Region: DUF72; pfam01904 452471002890 GrpE; Region: GrpE; pfam01025 452471002891 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 452471002892 dimer interface [polypeptide binding]; other site 452471002893 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 452471002894 chaperone protein DnaJ; Provisional; Region: PRK14289 452471002895 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 452471002896 HSP70 interaction site [polypeptide binding]; other site 452471002897 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 452471002898 substrate binding site [polypeptide binding]; other site 452471002899 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 452471002900 Zn binding sites [ion binding]; other site 452471002901 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 452471002902 dimer interface [polypeptide binding]; other site 452471002903 signal recognition particle protein; Provisional; Region: PRK10867 452471002904 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 452471002905 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 452471002906 P loop; other site 452471002907 GTP binding site [chemical binding]; other site 452471002908 Signal peptide binding domain; Region: SRP_SPB; pfam02978 452471002909 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 452471002910 Transglycosylase; Region: Transgly; pfam00912 452471002911 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 452471002912 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452471002913 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 452471002914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452471002915 Walker A/P-loop; other site 452471002916 ATP binding site [chemical binding]; other site 452471002917 Q-loop/lid; other site 452471002918 ABC transporter signature motif; other site 452471002919 Walker B; other site 452471002920 D-loop; other site 452471002921 H-loop/switch region; other site 452471002922 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471002923 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471002924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 452471002925 Transposase; Region: DEDD_Tnp_IS110; pfam01548 452471002926 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 452471002927 Transposase IS200 like; Region: Y1_Tnp; pfam01797 452471002928 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471002929 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471002930 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471002931 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471002932 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471002933 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 452471002934 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 452471002935 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452471002936 catalytic residue [active] 452471002937 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002938 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002939 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002940 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002941 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002942 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002943 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002944 Fe-S metabolism associated domain; Region: SufE; cl00951 452471002945 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 452471002946 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452471002947 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452471002948 active site 452471002949 ATP binding site [chemical binding]; other site 452471002950 substrate binding site [chemical binding]; other site 452471002951 activation loop (A-loop); other site 452471002952 Predicted ATPase [General function prediction only]; Region: COG3899 452471002953 AAA ATPase domain; Region: AAA_16; pfam13191 452471002954 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452471002955 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452471002956 PAS fold; Region: PAS_3; pfam08447 452471002957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452471002958 putative active site [active] 452471002959 heme pocket [chemical binding]; other site 452471002960 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452471002961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452471002962 dimer interface [polypeptide binding]; other site 452471002963 phosphorylation site [posttranslational modification] 452471002964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452471002965 ATP binding site [chemical binding]; other site 452471002966 Mg2+ binding site [ion binding]; other site 452471002967 G-X-G motif; other site 452471002968 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452471002969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452471002970 active site 452471002971 phosphorylation site [posttranslational modification] 452471002972 intermolecular recognition site; other site 452471002973 dimerization interface [polypeptide binding]; other site 452471002974 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 452471002975 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002976 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471002977 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002978 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002979 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002980 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002981 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471002982 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471002983 Disulphide isomerase; Region: Disulph_isomer; cl05813 452471002984 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 452471002985 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452471002986 catalytic triad [active] 452471002987 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471002988 Na binding site [ion binding]; other site 452471002989 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452471002990 Zn2+ binding site [ion binding]; other site 452471002991 Mg2+ binding site [ion binding]; other site 452471002992 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 452471002993 active site 452471002994 DNA binding site [nucleotide binding] 452471002995 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 452471002996 UbiA prenyltransferase family; Region: UbiA; pfam01040 452471002997 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 452471002998 nucleophilic elbow; other site 452471002999 catalytic triad; other site 452471003000 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003001 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471003002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 452471003003 Transposase; Region: DEDD_Tnp_IS110; pfam01548 452471003004 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 452471003005 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471003006 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 452471003007 C-terminal peptidase (prc); Region: prc; TIGR00225 452471003008 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 452471003009 protein binding site [polypeptide binding]; other site 452471003010 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 452471003011 Catalytic dyad [active] 452471003012 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 452471003013 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452471003014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452471003015 Walker A/P-loop; other site 452471003016 ATP binding site [chemical binding]; other site 452471003017 Q-loop/lid; other site 452471003018 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452471003019 ABC transporter signature motif; other site 452471003020 Walker B; other site 452471003021 D-loop; other site 452471003022 ABC transporter; Region: ABC_tran_2; pfam12848 452471003023 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452471003024 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 452471003025 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 452471003026 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 452471003027 4Fe-4S binding domain; Region: Fer4; cl02805 452471003028 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 452471003029 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 452471003030 gamma subunit interface [polypeptide binding]; other site 452471003031 LBP interface [polypeptide binding]; other site 452471003032 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 452471003033 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 452471003034 Walker A/P-loop; other site 452471003035 ATP binding site [chemical binding]; other site 452471003036 Q-loop/lid; other site 452471003037 ABC transporter signature motif; other site 452471003038 Walker B; other site 452471003039 D-loop; other site 452471003040 H-loop/switch region; other site 452471003041 Permease; Region: Permease; pfam02405 452471003042 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 452471003043 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 452471003044 ABC-ATPase subunit interface; other site 452471003045 dimer interface [polypeptide binding]; other site 452471003046 putative PBP binding regions; other site 452471003047 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 452471003048 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003049 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003050 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 452471003051 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 452471003052 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 452471003053 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 452471003054 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 452471003055 intersubunit interface [polypeptide binding]; other site 452471003056 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 452471003057 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 452471003058 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 452471003059 FeoA domain; Region: FeoA; pfam04023 452471003060 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 452471003061 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 452471003062 trimer interface [polypeptide binding]; other site 452471003063 active site 452471003064 substrate binding site [chemical binding]; other site 452471003065 CoA binding site [chemical binding]; other site 452471003066 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471003067 Na binding site [ion binding]; other site 452471003068 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 452471003069 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452471003070 Zn2+ binding site [ion binding]; other site 452471003071 Mg2+ binding site [ion binding]; other site 452471003072 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471003073 Na binding site [ion binding]; other site 452471003074 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 452471003075 Clp amino terminal domain; Region: Clp_N; pfam02861 452471003076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471003077 Walker A motif; other site 452471003078 ATP binding site [chemical binding]; other site 452471003079 Walker B motif; other site 452471003080 arginine finger; other site 452471003081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471003082 Walker A motif; other site 452471003083 ATP binding site [chemical binding]; other site 452471003084 Walker B motif; other site 452471003085 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 452471003086 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 452471003087 TrkA-N domain; Region: TrkA_N; pfam02254 452471003088 TrkA-C domain; Region: TrkA_C; pfam02080 452471003089 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 452471003090 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 452471003091 PspC domain; Region: PspC; pfam04024 452471003092 AAA domain; Region: AAA_14; pfam13173 452471003093 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 452471003094 peptide chain release factor 2; Region: prfB; TIGR00020 452471003095 This domain is found in peptide chain release factors; Region: PCRF; smart00937 452471003096 RF-1 domain; Region: RF-1; pfam00472 452471003097 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 452471003098 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 452471003099 active site 452471003100 substrate-binding site [chemical binding]; other site 452471003101 metal-binding site [ion binding] 452471003102 ATP binding site [chemical binding]; other site 452471003103 Bifunctional nuclease; Region: DNase-RNase; pfam02577 452471003104 UvrB/uvrC motif; Region: UVR; pfam02151 452471003105 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 452471003106 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 452471003107 putative acyl-acceptor binding pocket; other site 452471003108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471003109 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471003110 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003111 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003112 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471003113 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003114 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471003115 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452471003116 G1 box; other site 452471003117 GTP/Mg2+ binding site [chemical binding]; other site 452471003118 Switch I region; other site 452471003119 G3 box; other site 452471003120 Switch II region; other site 452471003121 G4 box; other site 452471003122 TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; Region: TAF4; cl05005 452471003123 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471003124 Substrate binding site [chemical binding]; other site 452471003125 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 452471003126 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452471003127 G1 box; other site 452471003128 GTP/Mg2+ binding site [chemical binding]; other site 452471003129 Switch I region; other site 452471003130 G3 box; other site 452471003131 Switch II region; other site 452471003132 G4 box; other site 452471003133 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 452471003134 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 452471003135 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 452471003136 NADP binding site [chemical binding]; other site 452471003137 active site 452471003138 putative substrate binding site [chemical binding]; other site 452471003139 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 452471003140 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 452471003141 NAD binding site [chemical binding]; other site 452471003142 substrate binding site [chemical binding]; other site 452471003143 homodimer interface [polypeptide binding]; other site 452471003144 active site 452471003145 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 452471003146 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 452471003147 dimer interface [polypeptide binding]; other site 452471003148 active site 452471003149 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 452471003150 dimer interface [polypeptide binding]; other site 452471003151 active site 452471003152 Ubiquitin carboxyl-terminal hydrolase; Region: UCH; pfam00443 452471003153 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 452471003154 active site 452471003155 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cd02257 452471003156 active site 452471003157 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 452471003158 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 452471003159 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 452471003160 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471003161 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 452471003162 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471003163 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003164 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003165 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 452471003166 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 452471003167 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 452471003168 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 452471003169 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 452471003170 Phage protein D [General function prediction only]; Region: COG3500 452471003171 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 452471003172 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 452471003173 Uncharacterized conserved protein [Function unknown]; Region: COG4104 452471003174 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 452471003175 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471003176 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 452471003177 NADH dehydrogenase subunit B; Validated; Region: PRK06411 452471003178 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 452471003179 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003180 Sel1-like repeats; Region: SEL1; smart00671 452471003181 Sel1-like repeats; Region: SEL1; smart00671 452471003182 Sel1-like repeats; Region: SEL1; smart00671 452471003183 Sel1-like repeats; Region: SEL1; smart00671 452471003184 Sel1-like repeats; Region: SEL1; smart00671 452471003185 Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685 452471003186 YceG-like family; Region: YceG; pfam02618 452471003187 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 452471003188 dimerization interface [polypeptide binding]; other site 452471003189 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 452471003190 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 452471003191 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 452471003192 metal binding site [ion binding]; metal-binding site 452471003193 dimer interface [polypeptide binding]; other site 452471003194 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 452471003195 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 452471003196 RNA/DNA hybrid binding site [nucleotide binding]; other site 452471003197 active site 452471003198 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 452471003199 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 452471003200 Probable Catalytic site; other site 452471003201 metal-binding site 452471003202 hypothetical protein; Validated; Region: PRK00153 452471003203 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 452471003204 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 452471003205 nucleotide binding site/active site [active] 452471003206 HIT family signature motif; other site 452471003207 catalytic residue [active] 452471003208 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 452471003209 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 452471003210 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452471003211 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 452471003212 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 452471003213 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 452471003214 active site 452471003215 homodimer interface [polypeptide binding]; other site 452471003216 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003217 Sel1-like repeats; Region: SEL1; smart00671 452471003218 Sel1-like repeats; Region: SEL1; smart00671 452471003219 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003220 Sel1-like repeats; Region: SEL1; smart00671 452471003221 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 452471003222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452471003223 ATP binding site [chemical binding]; other site 452471003224 Mg2+ binding site [ion binding]; other site 452471003225 G-X-G motif; other site 452471003226 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 452471003227 anchoring element; other site 452471003228 dimer interface [polypeptide binding]; other site 452471003229 ATP binding site [chemical binding]; other site 452471003230 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 452471003231 active site 452471003232 putative metal-binding site [ion binding]; other site 452471003233 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 452471003234 Patatin [General function prediction only]; Region: COG3621 452471003235 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 452471003236 active site 452471003237 nucleophile elbow; other site 452471003238 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003239 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471003240 Sel1-like repeats; Region: SEL1; smart00671 452471003241 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003242 Sel1-like repeats; Region: SEL1; smart00671 452471003243 Sel1-like repeats; Region: SEL1; smart00671 452471003244 Sel1-like repeats; Region: SEL1; smart00671 452471003245 Sel1-like repeats; Region: SEL1; smart00671 452471003246 Sel1-like repeats; Region: SEL1; smart00671 452471003247 F-box-like; Region: F-box-like; pfam12937 452471003248 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471003249 Leucine-rich repeats; other site 452471003250 Substrate binding site [chemical binding]; other site 452471003251 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471003252 Leucine-rich repeats; other site 452471003253 Substrate binding site [chemical binding]; other site 452471003254 potential frameshift: common BLAST hit: gi|189502477|ref|YP_001958194.1| transposase IS4 family protein 452471003255 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471003256 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003257 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471003258 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471003260 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471003261 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 452471003262 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 452471003263 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 452471003264 Colicin V production protein; Region: Colicin_V; pfam02674 452471003265 potential frameshift: common BLAST hit: gi|189502489|ref|YP_001958206.1| transposase IS4 family protein 452471003266 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471003267 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003268 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); Region: PCMT; pfam01135 452471003269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452471003270 S-adenosylmethionine binding site [chemical binding]; other site 452471003271 Transposase IS200 like; Region: Y1_Tnp; pfam01797 452471003272 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 452471003273 potential frameshift: common BLAST hit: gi|189502489|ref|YP_001958206.1| transposase IS4 family protein 452471003274 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471003275 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003276 GTPase Era; Reviewed; Region: era; PRK00089 452471003277 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 452471003278 G1 box; other site 452471003279 GTP/Mg2+ binding site [chemical binding]; other site 452471003280 Switch I region; other site 452471003281 G2 box; other site 452471003282 Switch II region; other site 452471003283 G3 box; other site 452471003284 G4 box; other site 452471003285 G5 box; other site 452471003286 KH domain; Region: KH_2; pfam07650 452471003287 DivIVA protein; Region: DivIVA; pfam05103 452471003288 DivIVA domain; Region: DivI1A_domain; TIGR03544 452471003289 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 452471003290 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 452471003291 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003292 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003293 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471003294 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003295 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003296 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003297 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003298 SecA DEAD-like domain; Region: SecA_DEAD; pfam07517 452471003299 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 452471003300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452471003301 nucleotide binding region [chemical binding]; other site 452471003302 ATP-binding site [chemical binding]; other site 452471003303 potential frameshift: common BLAST hit: gi|189502533|ref|YP_001958250.1| transposase IS4 family protein 452471003304 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471003305 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452471003306 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471003307 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 452471003308 DNA topoisomerase I; Provisional; Region: PRK08780 452471003309 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 452471003310 active site 452471003311 interdomain interaction site; other site 452471003312 putative metal-binding site [ion binding]; other site 452471003313 nucleotide binding site [chemical binding]; other site 452471003314 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 452471003315 domain I; other site 452471003316 DNA binding groove [nucleotide binding] 452471003317 phosphate binding site [ion binding]; other site 452471003318 domain II; other site 452471003319 domain III; other site 452471003320 nucleotide binding site [chemical binding]; other site 452471003321 catalytic site [active] 452471003322 domain IV; other site 452471003323 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 452471003324 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 452471003325 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 452471003326 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 452471003327 putative active site [active] 452471003328 Mn binding site [ion binding]; other site 452471003329 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003330 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003331 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471003332 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003333 Ankyrin repeat; Region: Ank; pfam00023 452471003334 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003335 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003336 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003337 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003338 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003339 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003340 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003341 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003342 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003343 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003344 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003345 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003346 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003347 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003348 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003349 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 452471003350 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 452471003351 Ligand binding site; other site 452471003352 Putative Catalytic site; other site 452471003353 DXD motif; other site 452471003354 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 452471003355 active site 452471003356 Ap6A binding site [chemical binding]; other site 452471003357 nudix motif; other site 452471003358 metal binding site [ion binding]; metal-binding site 452471003359 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 452471003360 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 452471003361 Transposase domain (DUF772); Region: DUF772; pfam05598 452471003362 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471003363 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 452471003364 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471003365 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452471003366 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452471003367 active site 452471003368 ATP binding site [chemical binding]; other site 452471003369 substrate binding site [chemical binding]; other site 452471003370 activation loop (A-loop); other site 452471003371 AAA ATPase domain; Region: AAA_16; pfam13191 452471003372 Predicted ATPase [General function prediction only]; Region: COG3899 452471003373 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452471003374 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452471003375 PAS fold; Region: PAS_3; pfam08447 452471003376 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452471003377 putative active site [active] 452471003378 heme pocket [chemical binding]; other site 452471003379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452471003380 dimer interface [polypeptide binding]; other site 452471003381 phosphorylation site [posttranslational modification] 452471003382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452471003383 ATP binding site [chemical binding]; other site 452471003384 Mg2+ binding site [ion binding]; other site 452471003385 G-X-G motif; other site 452471003386 Response regulator receiver domain; Region: Response_reg; pfam00072 452471003387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452471003388 active site 452471003389 phosphorylation site [posttranslational modification] 452471003390 intermolecular recognition site; other site 452471003391 dimerization interface [polypeptide binding]; other site 452471003392 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471003393 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 452471003394 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 452471003395 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 452471003396 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 452471003397 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 452471003398 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452471003399 ATP binding site [chemical binding]; other site 452471003400 putative Mg++ binding site [ion binding]; other site 452471003401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452471003402 nucleotide binding region [chemical binding]; other site 452471003403 ATP-binding site [chemical binding]; other site 452471003404 RQC domain; Region: RQC; pfam09382 452471003405 HRDC domain; Region: HRDC; pfam00570 452471003406 GldH lipoprotein; Region: GldH_lipo; pfam14109 452471003407 RecX family; Region: RecX; pfam02631 452471003408 DNA repair protein RadA; Provisional; Region: PRK11823 452471003409 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 452471003410 Walker A motif/ATP binding site; other site 452471003411 ATP binding site [chemical binding]; other site 452471003412 Walker B motif; other site 452471003413 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 452471003414 GTP-binding protein Der; Reviewed; Region: PRK00093 452471003415 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 452471003416 G1 box; other site 452471003417 GTP/Mg2+ binding site [chemical binding]; other site 452471003418 Switch I region; other site 452471003419 G2 box; other site 452471003420 Switch II region; other site 452471003421 G3 box; other site 452471003422 G4 box; other site 452471003423 G5 box; other site 452471003424 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 452471003425 G1 box; other site 452471003426 GTP/Mg2+ binding site [chemical binding]; other site 452471003427 Switch I region; other site 452471003428 G2 box; other site 452471003429 G3 box; other site 452471003430 Switch II region; other site 452471003431 G4 box; other site 452471003432 G5 box; other site 452471003433 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 452471003434 putative ABC transporter; Region: ycf24; CHL00085 452471003435 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 452471003436 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 452471003437 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 452471003438 Transposase domain (DUF772); Region: DUF772; pfam05598 452471003439 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471003440 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 452471003441 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 452471003442 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 452471003443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452471003444 ATP binding site [chemical binding]; other site 452471003445 Mg2+ binding site [ion binding]; other site 452471003446 G-X-G motif; other site 452471003447 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 452471003448 ATP binding site [chemical binding]; other site 452471003449 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 452471003450 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003451 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471003452 Winged helix-turn helix; Region: HTH_29; pfam13551 452471003453 Integrase core domain; Region: rve; pfam00665 452471003454 Integrase core domain; Region: rve_3; cl15866 452471003455 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471003456 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471003457 Transposase domain (DUF772); Region: DUF772; pfam05598 452471003458 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471003459 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 452471003460 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 452471003461 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 452471003462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471003463 Walker A motif; other site 452471003464 ATP binding site [chemical binding]; other site 452471003465 Walker B motif; other site 452471003466 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 452471003467 Clp protease; Region: CLP_protease; pfam00574 452471003468 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 452471003469 oligomer interface [polypeptide binding]; other site 452471003470 active site residues [active] 452471003471 trigger factor; Region: tig; TIGR00115 452471003472 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 452471003473 HD domain; Region: HD_4; pfam13328 452471003474 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 452471003475 synthetase active site [active] 452471003476 NTP binding site [chemical binding]; other site 452471003477 metal binding site [ion binding]; metal-binding site 452471003478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452471003479 metabolite-proton symporter; Region: 2A0106; TIGR00883 452471003480 putative substrate translocation pore; other site 452471003481 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003482 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471003483 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 452471003484 RNA/DNA hybrid binding site [nucleotide binding]; other site 452471003485 active site 452471003486 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 452471003487 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00196 452471003488 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452471003489 potential frameshift: common BLAST hit: gi|189502533|ref|YP_001958250.1| transposase IS4 family protein 452471003490 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471003491 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471003492 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452471003493 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 452471003494 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471003495 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 452471003496 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 452471003497 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 452471003498 OstA-like protein; Region: OstA_2; pfam13100 452471003499 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 452471003500 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 452471003501 Ligand Binding Site [chemical binding]; other site 452471003502 TilS substrate C-terminal domain; Region: TilS_C; smart00977 452471003503 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 452471003504 EamA-like transporter family; Region: EamA; pfam00892 452471003505 EamA-like transporter family; Region: EamA; pfam00892 452471003506 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 452471003507 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 452471003508 Ligand Binding Site [chemical binding]; other site 452471003509 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 452471003510 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 452471003511 trmE is a tRNA modification GTPase; Region: trmE; cd04164 452471003512 G1 box; other site 452471003513 GTP/Mg2+ binding site [chemical binding]; other site 452471003514 Switch I region; other site 452471003515 G2 box; other site 452471003516 Switch II region; other site 452471003517 G3 box; other site 452471003518 G4 box; other site 452471003519 G5 box; other site 452471003520 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 452471003521 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 452471003522 metal-binding site [ion binding] 452471003523 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452471003524 nudix motif; other site 452471003525 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 452471003526 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 452471003527 dimerization interface [polypeptide binding]; other site 452471003528 active site 452471003529 metal binding site [ion binding]; metal-binding site 452471003530 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 452471003531 dsRNA binding site [nucleotide binding]; other site 452471003532 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452471003533 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452471003534 dimer interface [polypeptide binding]; other site 452471003535 active site 452471003536 acyl carrier protein; Provisional; Region: acpP; PRK00982 452471003537 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 452471003538 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 452471003539 domain interfaces; other site 452471003540 active site 452471003541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452471003542 AAA domain; Region: AAA_22; pfam13401 452471003543 Walker A motif; other site 452471003544 ATP binding site [chemical binding]; other site 452471003545 Walker B motif; other site 452471003546 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 452471003547 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003548 Sel1-like repeats; Region: SEL1; smart00671 452471003549 Sel1-like repeats; Region: SEL1; smart00671 452471003550 Sel1-like repeats; Region: SEL1; smart00671 452471003551 Sel1-like repeats; Region: SEL1; smart00671 452471003552 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 452471003553 putative active site [active] 452471003554 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 452471003555 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471003556 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003557 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003558 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003559 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003560 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003561 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003562 Sel1-like repeats; Region: SEL1; smart00671 452471003563 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003564 Sel1-like repeats; Region: SEL1; smart00671 452471003565 Sel1-like repeats; Region: SEL1; smart00671 452471003566 Sel1-like repeats; Region: SEL1; smart00671 452471003567 Sel1-like repeats; Region: SEL1; smart00671 452471003568 Sel1-like repeats; Region: SEL1; smart00671 452471003569 Sel1-like repeats; Region: SEL1; smart00671 452471003570 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003571 Sel1-like repeats; Region: SEL1; smart00671 452471003572 Sel1-like repeats; Region: SEL1; smart00671 452471003573 Sel1-like repeats; Region: SEL1; smart00671 452471003574 Sel1-like repeats; Region: SEL1; smart00671 452471003575 Sel1-like repeats; Region: SEL1; smart00671 452471003576 Sel1-like repeats; Region: SEL1; smart00671 452471003577 Sel1-like repeats; Region: SEL1; smart00671 452471003578 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003579 Sel1-like repeats; Region: SEL1; smart00671 452471003580 Sel1-like repeats; Region: SEL1; smart00671 452471003581 Sel1-like repeats; Region: SEL1; smart00671 452471003582 Sel1-like repeats; Region: SEL1; smart00671 452471003583 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003584 Sel1-like repeats; Region: SEL1; smart00671 452471003585 Sel1-like repeats; Region: SEL1; smart00671 452471003586 Sel1-like repeats; Region: SEL1; smart00671 452471003587 Sel1-like repeats; Region: SEL1; smart00671 452471003588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471003589 TPR motif; other site 452471003590 binding surface 452471003591 Modified RING finger domain; Region: Ubox; smart00504 452471003592 Sel1-like repeats; Region: SEL1; smart00671 452471003593 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003594 Sel1-like repeats; Region: SEL1; smart00671 452471003595 Sel1-like repeats; Region: SEL1; smart00671 452471003596 Sel1 repeat; Region: Sel1; pfam08238 452471003597 Sel1-like repeats; Region: SEL1; smart00671 452471003598 Sel1-like repeats; Region: SEL1; smart00671 452471003599 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003600 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471003601 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003602 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003603 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003604 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003605 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003606 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003607 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003608 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 452471003609 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471003610 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 452471003611 F-box-like; Region: F-box-like; pfam12937 452471003612 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471003613 F-box-like; Region: F-box-like; pfam12937 452471003614 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471003615 Leucine-rich repeats; other site 452471003616 Substrate binding site [chemical binding]; other site 452471003617 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003618 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 452471003619 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471003620 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471003622 binding surface 452471003623 TPR motif; other site 452471003624 Sel1-like repeats; Region: SEL1; smart00671 452471003625 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003626 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003627 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471003628 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003629 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003630 DNA protecting protein DprA; Region: dprA; TIGR00732 452471003631 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 452471003632 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 452471003633 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 452471003634 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452471003635 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 452471003636 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 452471003637 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 452471003638 HflX GTPase family; Region: HflX; cd01878 452471003639 G1 box; other site 452471003640 GTP/Mg2+ binding site [chemical binding]; other site 452471003641 Switch I region; other site 452471003642 G2 box; other site 452471003643 G3 box; other site 452471003644 Switch II region; other site 452471003645 G4 box; other site 452471003646 G5 box; other site 452471003647 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 452471003648 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452471003649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452471003650 S-adenosylmethionine binding site [chemical binding]; other site 452471003651 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 452471003652 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 452471003653 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471003654 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 452471003655 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 452471003656 active site 452471003657 Int/Topo IB signature motif; other site 452471003658 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 452471003659 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 452471003660 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 452471003661 dimer interface [polypeptide binding]; other site 452471003662 putative anticodon binding site; other site 452471003663 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 452471003664 motif 1; other site 452471003665 active site 452471003666 motif 2; other site 452471003667 motif 3; other site 452471003668 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 452471003669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471003670 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471003671 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 452471003672 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471003673 Leucine-rich repeats; other site 452471003674 Substrate binding site [chemical binding]; other site 452471003675 Leucine rich repeat; Region: LRR_8; pfam13855 452471003676 Leucine rich repeat; Region: LRR_8; pfam13855 452471003677 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 452471003678 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 452471003679 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 452471003680 Cell division protein FtsA; Region: FtsA; smart00842 452471003681 Cell division protein FtsA; Region: FtsA; pfam14450 452471003682 cell division protein FtsZ; Region: ftsZ; TIGR00065 452471003683 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 452471003684 nucleotide binding site [chemical binding]; other site 452471003685 SulA interaction site; other site 452471003686 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003687 Sel1-like repeats; Region: SEL1; smart00671 452471003688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471003689 TPR motif; other site 452471003690 binding surface 452471003691 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471003693 TPR motif; other site 452471003694 binding surface 452471003695 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003696 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471003697 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003698 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003699 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003700 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003701 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003702 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003703 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003704 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003705 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003706 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 452471003707 AAA domain; Region: AAA_14; pfam13173 452471003708 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 452471003709 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 452471003710 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452471003711 active site 452471003712 HIGH motif; other site 452471003713 nucleotide binding site [chemical binding]; other site 452471003714 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 452471003715 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 452471003716 active site 452471003717 KMSKS motif; other site 452471003718 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 452471003719 tRNA binding surface [nucleotide binding]; other site 452471003720 anticodon binding site; other site 452471003721 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 452471003722 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 452471003723 RibD C-terminal domain; Region: RibD_C; cl17279 452471003724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 452471003725 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452471003726 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452471003727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452471003728 Walker A/P-loop; other site 452471003729 ATP binding site [chemical binding]; other site 452471003730 Q-loop/lid; other site 452471003731 ABC transporter signature motif; other site 452471003732 Walker B; other site 452471003733 D-loop; other site 452471003734 H-loop/switch region; other site 452471003735 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 452471003736 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 452471003737 Domain of unknown function (DUF897); Region: DUF897; pfam05982 452471003738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 452471003739 Transposase; Region: DEDD_Tnp_IS110; pfam01548 452471003740 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 452471003741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 452471003742 Transposase; Region: DEDD_Tnp_IS110; pfam01548 452471003743 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 452471003744 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471003745 Winged helix-turn helix; Region: HTH_29; pfam13551 452471003746 Integrase core domain; Region: rve; pfam00665 452471003747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 452471003748 Integrase core domain; Region: rve_3; pfam13683 452471003749 Sel1 repeat; Region: Sel1; cl02723 452471003750 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471003751 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 452471003752 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 452471003753 active site 452471003754 HIGH motif; other site 452471003755 KMSKS motif; other site 452471003756 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 452471003757 tRNA binding surface [nucleotide binding]; other site 452471003758 anticodon binding site; other site 452471003759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471003760 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 452471003761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 452471003762 Transposase; Region: DEDD_Tnp_IS110; pfam01548 452471003763 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 452471003764 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452471003765 ATP binding site [chemical binding]; other site 452471003766 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471003767 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003768 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003769 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003770 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003771 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003772 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003773 Sel1-like repeats; Region: SEL1; smart00671 452471003774 Sel1-like repeats; Region: SEL1; smart00671 452471003775 Sel1-like repeats; Region: SEL1; smart00671 452471003776 Sel1-like repeats; Region: SEL1; smart00671 452471003777 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003778 Sel1-like repeats; Region: SEL1; smart00671 452471003779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471003780 TPR motif; other site 452471003781 binding surface 452471003782 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003783 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003784 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 452471003785 Smr domain; Region: Smr; pfam01713 452471003786 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471003787 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471003788 Protein kinase domain; Region: Pkinase; pfam00069 452471003789 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452471003790 active site 452471003791 ATP binding site [chemical binding]; other site 452471003792 substrate binding site [chemical binding]; other site 452471003793 activation loop (A-loop); other site 452471003794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471003795 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471003796 binding surface 452471003797 TPR motif; other site 452471003798 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471003799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471003800 binding surface 452471003801 TPR motif; other site 452471003802 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471003803 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471003804 binding surface 452471003805 TPR motif; other site 452471003806 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471003807 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471003808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471003809 binding surface 452471003810 TPR motif; other site 452471003811 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471003812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 452471003813 putative transposase; Provisional; Region: PRK09857 452471003814 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 452471003815 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003816 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471003817 DEAD-like helicases superfamily; Region: DEXDc; smart00487 452471003818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452471003819 ATP binding site [chemical binding]; other site 452471003820 putative Mg++ binding site [ion binding]; other site 452471003821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452471003822 nucleotide binding region [chemical binding]; other site 452471003823 ATP-binding site [chemical binding]; other site 452471003824 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 452471003825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 452471003826 Transposase IS200 like; Region: Y1_Tnp; pfam01797 452471003827 comF family protein; Region: comF; TIGR00201 452471003828 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452471003829 active site 452471003830 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003831 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003832 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471003833 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003834 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003835 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003836 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003837 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003838 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003839 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003840 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003841 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471003842 ribonuclease R; Region: RNase_R; TIGR02063 452471003843 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 452471003844 RNB domain; Region: RNB; pfam00773 452471003845 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 452471003846 RNA binding site [nucleotide binding]; other site 452471003847 Sporulation related domain; Region: SPOR; pfam05036 452471003848 RmuC family; Region: RmuC; pfam02646 452471003849 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471003850 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471003851 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003852 Sel1-like repeats; Region: SEL1; smart00671 452471003853 Sel1-like repeats; Region: SEL1; smart00671 452471003854 Sel1-like repeats; Region: SEL1; smart00671 452471003855 Sel1-like repeats; Region: SEL1; smart00671 452471003856 recombinase A; Provisional; Region: recA; PRK09354 452471003857 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 452471003858 hexamer interface [polypeptide binding]; other site 452471003859 Walker A motif; other site 452471003860 ATP binding site [chemical binding]; other site 452471003861 Walker B motif; other site 452471003862 TPR repeat; Region: TPR_11; pfam13414 452471003863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471003864 binding surface 452471003865 TPR motif; other site 452471003866 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452471003867 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 452471003868 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 452471003869 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 452471003870 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 452471003871 ligand binding site [chemical binding]; other site 452471003872 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 452471003873 active site 452471003874 catalytic residues [active] 452471003875 metal binding site [ion binding]; metal-binding site 452471003876 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 452471003877 Domain of unknown function (DUF4207); Region: DUF4207; pfam13904 452471003878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471003879 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471003880 hypothetical protein; Provisional; Region: PRK13665 452471003881 GH3 auxin-responsive promoter; Region: GH3; pfam03321 452471003882 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 452471003883 FAD binding domain; Region: FAD_binding_4; pfam01565 452471003884 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 452471003885 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 452471003886 catalytic motif [active] 452471003887 Zn binding site [ion binding]; other site 452471003888 YcxB-like protein; Region: YcxB; pfam14317 452471003889 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 452471003890 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 452471003891 DEAD-like helicases superfamily; Region: DEXDc; smart00487 452471003892 ATP binding site [chemical binding]; other site 452471003893 Mg++ binding site [ion binding]; other site 452471003894 motif III; other site 452471003895 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452471003896 nucleotide binding region [chemical binding]; other site 452471003897 ATP-binding site [chemical binding]; other site 452471003898 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 452471003899 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 452471003900 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 452471003901 Winged helix-turn helix; Region: HTH_29; pfam13551 452471003902 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471003903 ribosome recycling factor; Reviewed; Region: frr; PRK00083 452471003904 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 452471003905 hinge region; other site 452471003906 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 452471003907 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 452471003908 putative active site [active] 452471003909 substrate binding site [chemical binding]; other site 452471003910 putative cosubstrate binding site; other site 452471003911 catalytic site [active] 452471003912 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 452471003913 substrate binding site [chemical binding]; other site 452471003914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452471003915 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 452471003916 Walker A/P-loop; other site 452471003917 ATP binding site [chemical binding]; other site 452471003918 Q-loop/lid; other site 452471003919 ABC transporter signature motif; other site 452471003920 Walker B; other site 452471003921 D-loop; other site 452471003922 H-loop/switch region; other site 452471003923 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 452471003924 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 452471003925 homodimer interface [polypeptide binding]; other site 452471003926 metal binding site [ion binding]; metal-binding site 452471003927 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 452471003928 homodimer interface [polypeptide binding]; other site 452471003929 active site 452471003930 putative chemical substrate binding site [chemical binding]; other site 452471003931 metal binding site [ion binding]; metal-binding site 452471003932 Uncharacterized conserved protein [Function unknown]; Region: COG2155 452471003933 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 452471003934 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 452471003935 active site 452471003936 metal binding site [ion binding]; metal-binding site 452471003937 homotetramer interface [polypeptide binding]; other site 452471003938 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 452471003939 active site 452471003940 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471003941 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 452471003942 aminoacyl-tRNA ligase; Region: PLN02563 452471003943 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452471003944 active site 452471003945 HIGH motif; other site 452471003946 nucleotide binding site [chemical binding]; other site 452471003947 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452471003948 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 452471003949 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452471003950 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452471003951 active site 452471003952 KMSKS motif; other site 452471003953 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 452471003954 tRNA binding surface [nucleotide binding]; other site 452471003955 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 452471003956 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 452471003957 active site 452471003958 HIGH motif; other site 452471003959 dimer interface [polypeptide binding]; other site 452471003960 KMSKS motif; other site 452471003961 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 452471003962 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 452471003963 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452471003964 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 452471003965 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 452471003966 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 452471003967 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 452471003968 dihydrodipicolinate synthase; Region: dapA; TIGR00674 452471003969 dimer interface [polypeptide binding]; other site 452471003970 active site 452471003971 catalytic residue [active] 452471003972 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 452471003973 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 452471003974 nucleotide binding pocket [chemical binding]; other site 452471003975 K-X-D-G motif; other site 452471003976 catalytic site [active] 452471003977 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 452471003978 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 452471003979 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 452471003980 Dimer interface [polypeptide binding]; other site 452471003981 BRCT sequence motif; other site 452471003982 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 452471003983 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471003984 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471003985 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452471003986 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452471003987 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471003988 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471003989 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 452471003990 Transposase; Region: DEDD_Tnp_IS110; pfam01548 452471003991 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 452471003992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471003993 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471003994 F-box-like; Region: F-box-like; pfam12937 452471003995 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471003996 Leucine-rich repeats; other site 452471003997 potential frameshift: common BLAST hit: gi|189502695|ref|YP_001958412.1| transposase IS4 family protein 452471003998 DDE superfamily endonuclease; Region: DDE_4; cl17710 452471003999 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471004000 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471004001 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471004002 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452471004003 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 452471004004 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 452471004005 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 452471004006 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 452471004007 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 452471004008 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 452471004009 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 452471004010 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 452471004011 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 452471004012 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 452471004013 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 452471004014 DNA binding site [nucleotide binding] 452471004015 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 452471004016 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 452471004017 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 452471004018 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 452471004019 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 452471004020 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 452471004021 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 452471004022 RPB3 interaction site [polypeptide binding]; other site 452471004023 RPB1 interaction site [polypeptide binding]; other site 452471004024 RPB11 interaction site [polypeptide binding]; other site 452471004025 RPB10 interaction site [polypeptide binding]; other site 452471004026 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 452471004027 peripheral dimer interface [polypeptide binding]; other site 452471004028 core dimer interface [polypeptide binding]; other site 452471004029 L10 interface [polypeptide binding]; other site 452471004030 L11 interface [polypeptide binding]; other site 452471004031 putative EF-Tu interaction site [polypeptide binding]; other site 452471004032 putative EF-G interaction site [polypeptide binding]; other site 452471004033 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 452471004034 23S rRNA interface [nucleotide binding]; other site 452471004035 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 452471004036 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 452471004037 mRNA/rRNA interface [nucleotide binding]; other site 452471004038 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 452471004039 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 452471004040 23S rRNA interface [nucleotide binding]; other site 452471004041 L7/L12 interface [polypeptide binding]; other site 452471004042 putative thiostrepton binding site; other site 452471004043 L25 interface [polypeptide binding]; other site 452471004044 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 452471004045 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 452471004046 putative homodimer interface [polypeptide binding]; other site 452471004047 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 452471004048 heterodimer interface [polypeptide binding]; other site 452471004049 homodimer interface [polypeptide binding]; other site 452471004050 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 452471004051 elongation factor Tu; Reviewed; Region: PRK12735 452471004052 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 452471004053 G1 box; other site 452471004054 GEF interaction site [polypeptide binding]; other site 452471004055 GTP/Mg2+ binding site [chemical binding]; other site 452471004056 Switch I region; other site 452471004057 G2 box; other site 452471004058 G3 box; other site 452471004059 Switch II region; other site 452471004060 G4 box; other site 452471004061 G5 box; other site 452471004062 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 452471004063 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 452471004064 Antibiotic Binding Site [chemical binding]; other site 452471004065 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 452471004066 Peptidase family M1; Region: Peptidase_M1; pfam01433 452471004067 Zn binding site [ion binding]; other site 452471004068 HEAT repeats; Region: HEAT_2; pfam13646 452471004069 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 452471004070 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 452471004071 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 452471004072 thymidylate synthase; Reviewed; Region: thyA; PRK01827 452471004073 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 452471004074 dimerization interface [polypeptide binding]; other site 452471004075 active site 452471004076 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452471004077 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 452471004078 Family description; Region: VCBS; pfam13517 452471004079 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 452471004080 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 452471004081 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 452471004082 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 452471004083 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471004084 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471004085 putative lipoprotein, rSAM/lipoprotein system; Region: lipo_with_rSAM; TIGR04134 452471004086 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 452471004087 nucleophile elbow; other site 452471004088 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 452471004089 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 452471004090 active site 452471004091 domain interfaces; other site 452471004092 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 452471004093 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 452471004094 Walker A/P-loop; other site 452471004095 ATP binding site [chemical binding]; other site 452471004096 Q-loop/lid; other site 452471004097 ABC transporter signature motif; other site 452471004098 Walker B; other site 452471004099 D-loop; other site 452471004100 H-loop/switch region; other site 452471004101 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 452471004102 DHH family; Region: DHH; pfam01368 452471004103 DHHA1 domain; Region: DHHA1; pfam02272 452471004104 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 452471004105 Helix-turn-helix domain; Region: HTH_28; pfam13518 452471004106 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 452471004107 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 452471004108 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 452471004109 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 452471004110 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 452471004111 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 452471004112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 452471004113 aspartate aminotransferase; Provisional; Region: PRK05764 452471004114 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452471004115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452471004116 homodimer interface [polypeptide binding]; other site 452471004117 catalytic residue [active] 452471004118 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 452471004119 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 452471004120 putative active site; other site 452471004121 catalytic residue [active] 452471004122 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 452471004123 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 452471004124 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 452471004125 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 452471004126 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 452471004127 glutaminase active site [active] 452471004128 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 452471004129 dimer interface [polypeptide binding]; other site 452471004130 active site 452471004131 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 452471004132 dimer interface [polypeptide binding]; other site 452471004133 active site 452471004134 Modified RING finger domain; Region: Ubox; smart00504 452471004135 Ankyrin repeat; Region: Ank; pfam00023 452471004136 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471004137 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471004138 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471004139 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471004140 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471004141 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471004142 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471004143 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471004144 Ankyrin repeat; Region: Ank; pfam00023 452471004145 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471004146 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471004147 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471004148 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471004149 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471004150 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471004151 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471004152 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471004153 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452471004154 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471004155 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471004156 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471004157 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471004158 Ankyrin repeat; Region: Ank; pfam00023 452471004159 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471004160 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471004161 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471004162 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452471004163 Sel1 repeat; Region: Sel1; pfam08238 452471004164 A Receptor for Ubiquitination Targets; Region: FBOX; smart00256 452471004165 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471004166 Leucine-rich repeats; other site 452471004167 Substrate binding site [chemical binding]; other site 452471004168 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452471004169 Leucine-rich repeats; other site 452471004170 Substrate binding site [chemical binding]; other site 452471004171 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 452471004172 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 452471004173 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452471004174 Beta-lactamase; Region: Beta-lactamase; cl17358 452471004175 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 452471004176 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 452471004177 nucleophilic elbow; other site 452471004178 catalytic triad; other site 452471004179 U-box domain; Region: U-box; cl17544 452471004180 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471004181 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452471004182 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452471004183 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 452471004184 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452471004185 active site 452471004186 ATP binding site [chemical binding]; other site 452471004187 substrate binding site [chemical binding]; other site 452471004188 activation loop (A-loop); other site 452471004189 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 452471004190 Na binding site [ion binding]; other site 452471004191 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452471004192 Zn2+ binding site [ion binding]; other site 452471004193 Mg2+ binding site [ion binding]; other site 452471004194 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 452471004195 RuvA N terminal domain; Region: RuvA_N; pfam01330 452471004196 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 452471004197 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 452471004198 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 452471004199 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 452471004200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 452471004201 binding surface 452471004202 TPR motif; other site 452471004203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471004204 binding surface 452471004205 TPR motif; other site 452471004206 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 452471004207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452471004208 binding surface 452471004209 TPR motif; other site 452471004210 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 452471004211 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 452471004212 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452471004213 Erythromycin esterase; Region: Erythro_esteras; pfam05139