-- dump date 20140619_022349 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1041809000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1041809000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1041809000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041809000004 Walker A motif; other site 1041809000005 ATP binding site [chemical binding]; other site 1041809000006 Walker B motif; other site 1041809000007 arginine finger; other site 1041809000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1041809000009 DnaA box-binding interface [nucleotide binding]; other site 1041809000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1041809000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1041809000012 putative DNA binding surface [nucleotide binding]; other site 1041809000013 dimer interface [polypeptide binding]; other site 1041809000014 beta-clamp/clamp loader binding surface; other site 1041809000015 beta-clamp/translesion DNA polymerase binding surface; other site 1041809000016 recombination protein F; Reviewed; Region: recF; PRK00064 1041809000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041809000018 Walker A/P-loop; other site 1041809000019 ATP binding site [chemical binding]; other site 1041809000020 Q-loop/lid; other site 1041809000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041809000022 ABC transporter signature motif; other site 1041809000023 Walker B; other site 1041809000024 D-loop; other site 1041809000025 H-loop/switch region; other site 1041809000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1041809000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041809000028 ATP binding site [chemical binding]; other site 1041809000029 Mg2+ binding site [ion binding]; other site 1041809000030 G-X-G motif; other site 1041809000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1041809000032 anchoring element; other site 1041809000033 dimer interface [polypeptide binding]; other site 1041809000034 ATP binding site [chemical binding]; other site 1041809000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1041809000036 active site 1041809000037 putative metal-binding site [ion binding]; other site 1041809000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1041809000039 DNA gyrase subunit A; Validated; Region: PRK05560 1041809000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1041809000041 CAP-like domain; other site 1041809000042 active site 1041809000043 primary dimer interface [polypeptide binding]; other site 1041809000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1041809000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1041809000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1041809000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1041809000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1041809000049 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1041809000050 Zn2+ binding site [ion binding]; other site 1041809000051 Mg2+ binding site [ion binding]; other site 1041809000052 seryl-tRNA synthetase; Provisional; Region: PRK05431 1041809000053 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1041809000054 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1041809000055 dimer interface [polypeptide binding]; other site 1041809000056 active site 1041809000057 motif 1; other site 1041809000058 motif 2; other site 1041809000059 motif 3; other site 1041809000060 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1041809000061 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1041809000062 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1041809000063 Part of AAA domain; Region: AAA_19; pfam13245 1041809000064 Family description; Region: UvrD_C_2; pfam13538 1041809000065 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1041809000066 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1041809000067 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1041809000068 active site 1041809000069 NTP binding site [chemical binding]; other site 1041809000070 metal binding triad [ion binding]; metal-binding site 1041809000071 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1041809000072 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1041809000073 generic binding surface II; other site 1041809000074 generic binding surface I; other site 1041809000075 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1041809000076 Zn2+ binding site [ion binding]; other site 1041809000077 Mg2+ binding site [ion binding]; other site 1041809000078 Predicted transcriptional regulators [Transcription]; Region: COG1695 1041809000079 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1041809000080 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 1041809000081 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1041809000082 dimer interface [polypeptide binding]; other site 1041809000083 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1041809000084 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1041809000085 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1041809000086 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1041809000087 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1041809000088 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1041809000089 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1041809000090 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1041809000091 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1041809000092 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041809000093 ATP binding site [chemical binding]; other site 1041809000094 putative Mg++ binding site [ion binding]; other site 1041809000095 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1041809000096 Chromate transporter; Region: Chromate_transp; pfam02417 1041809000097 Chromate transporter; Region: Chromate_transp; pfam02417 1041809000098 DHHW protein; Region: DHHW; pfam14286 1041809000099 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1041809000100 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 1041809000101 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1041809000102 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1041809000103 dimer interface [polypeptide binding]; other site 1041809000104 motif 1; other site 1041809000105 active site 1041809000106 motif 2; other site 1041809000107 motif 3; other site 1041809000108 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 1041809000109 anticodon binding site; other site 1041809000110 zinc-binding site [ion binding]; other site 1041809000111 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1041809000112 Domain of unknown function DUF21; Region: DUF21; pfam01595 1041809000113 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1041809000114 Transporter associated domain; Region: CorC_HlyC; smart01091 1041809000115 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1041809000116 nucleoside/Zn binding site; other site 1041809000117 dimer interface [polypeptide binding]; other site 1041809000118 catalytic motif [active] 1041809000119 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1041809000120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041809000121 Walker A motif; other site 1041809000122 ATP binding site [chemical binding]; other site 1041809000123 Walker B motif; other site 1041809000124 hypothetical protein; Validated; Region: PRK00153 1041809000125 recombination protein RecR; Reviewed; Region: recR; PRK00076 1041809000126 RecR protein; Region: RecR; pfam02132 1041809000127 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1041809000128 putative active site [active] 1041809000129 putative metal-binding site [ion binding]; other site 1041809000130 tetramer interface [polypeptide binding]; other site 1041809000131 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 1041809000132 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 1041809000133 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1041809000134 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1041809000135 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1041809000136 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1041809000137 putative ATP binding site [chemical binding]; other site 1041809000138 putative substrate interface [chemical binding]; other site 1041809000139 FemAB family; Region: FemAB; pfam02388 1041809000140 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1041809000141 Predicted methyltransferases [General function prediction only]; Region: COG0313 1041809000142 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1041809000143 putative SAM binding site [chemical binding]; other site 1041809000144 putative homodimer interface [polypeptide binding]; other site 1041809000145 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1041809000146 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1041809000147 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1041809000148 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1041809000149 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041809000150 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1041809000151 putative ADP-binding pocket [chemical binding]; other site 1041809000152 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041809000153 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1041809000154 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 1041809000155 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809000156 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1041809000157 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1041809000158 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041809000159 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1041809000160 putative ADP-binding pocket [chemical binding]; other site 1041809000161 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1041809000162 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1041809000163 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1041809000164 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1041809000165 Substrate binding site; other site 1041809000166 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1041809000167 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1041809000168 active site 1041809000169 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1041809000170 tetramer interface; other site 1041809000171 active site 1041809000172 Isochorismatase family; Region: Isochorismatase; pfam00857 1041809000173 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1041809000174 catalytic triad [active] 1041809000175 conserved cis-peptide bond; other site 1041809000176 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1041809000177 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1041809000178 dimer interface [polypeptide binding]; other site 1041809000179 ssDNA binding site [nucleotide binding]; other site 1041809000180 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1041809000181 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1041809000182 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1041809000183 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1041809000184 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1041809000185 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1041809000186 alanine racemase; Reviewed; Region: alr; PRK00053 1041809000187 active site 1041809000188 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1041809000189 dimer interface [polypeptide binding]; other site 1041809000190 substrate binding site [chemical binding]; other site 1041809000191 catalytic residues [active] 1041809000192 PemK-like protein; Region: PemK; pfam02452 1041809000193 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 1041809000194 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 1041809000195 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 1041809000196 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1041809000197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041809000198 Walker A/P-loop; other site 1041809000199 ATP binding site [chemical binding]; other site 1041809000200 Q-loop/lid; other site 1041809000201 ABC transporter signature motif; other site 1041809000202 Walker B; other site 1041809000203 D-loop; other site 1041809000204 H-loop/switch region; other site 1041809000205 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1041809000206 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1041809000207 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1041809000208 C-terminal peptidase (prc); Region: prc; TIGR00225 1041809000209 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1041809000210 protein binding site [polypeptide binding]; other site 1041809000211 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1041809000212 Catalytic dyad [active] 1041809000213 excinuclease ABC subunit B; Provisional; Region: PRK05298 1041809000214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041809000215 ATP binding site [chemical binding]; other site 1041809000216 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041809000217 nucleotide binding region [chemical binding]; other site 1041809000218 ATP-binding site [chemical binding]; other site 1041809000219 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1041809000220 UvrB/uvrC motif; Region: UVR; pfam02151 1041809000221 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1041809000222 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1041809000223 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1041809000224 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1041809000225 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1041809000226 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1041809000227 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1041809000228 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1041809000229 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1041809000230 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1041809000231 active site 1041809000232 catalytic site [active] 1041809000233 putative DNA binding site [nucleotide binding]; other site 1041809000234 GIY-YIG motif/motif A; other site 1041809000235 metal binding site [ion binding]; metal-binding site 1041809000236 UvrB/uvrC motif; Region: UVR; pfam02151 1041809000237 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1041809000238 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1041809000239 FAD binding domain; Region: FAD_binding_4; pfam01565 1041809000240 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1041809000241 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1041809000242 AAA domain; Region: AAA_18; pfam13238 1041809000243 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1041809000244 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1041809000245 putative substrate binding pocket [chemical binding]; other site 1041809000246 dimer interface [polypeptide binding]; other site 1041809000247 phosphate binding site [ion binding]; other site 1041809000248 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 1041809000249 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 1041809000250 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1041809000251 active site 1041809000252 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1041809000253 dimer interface [polypeptide binding]; other site 1041809000254 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1041809000255 Ligand Binding Site [chemical binding]; other site 1041809000256 Molecular Tunnel; other site 1041809000257 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 1041809000258 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1041809000259 active site 1041809000260 PHP Thumb interface [polypeptide binding]; other site 1041809000261 metal binding site [ion binding]; metal-binding site 1041809000262 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1041809000263 generic binding surface II; other site 1041809000264 generic binding surface I; other site 1041809000265 6-phosphofructokinase; Provisional; Region: PRK03202 1041809000266 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1041809000267 active site 1041809000268 ADP/pyrophosphate binding site [chemical binding]; other site 1041809000269 dimerization interface [polypeptide binding]; other site 1041809000270 allosteric effector site; other site 1041809000271 fructose-1,6-bisphosphate binding site; other site 1041809000272 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1041809000273 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1041809000274 active site 1041809000275 domain interfaces; other site 1041809000276 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1041809000277 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1041809000278 active site 1041809000279 DNA binding site [nucleotide binding] 1041809000280 Int/Topo IB signature motif; other site 1041809000281 Predicted ATPases [General function prediction only]; Region: COG1106 1041809000282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041809000283 Walker A/P-loop; other site 1041809000284 ATP binding site [chemical binding]; other site 1041809000285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041809000286 ABC transporter signature motif; other site 1041809000287 Walker B; other site 1041809000288 D-loop; other site 1041809000289 H-loop/switch region; other site 1041809000290 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 1041809000291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1041809000292 non-specific DNA binding site [nucleotide binding]; other site 1041809000293 salt bridge; other site 1041809000294 sequence-specific DNA binding site [nucleotide binding]; other site 1041809000295 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1041809000296 virus coat protein VP2; Provisional; Region: PHA02759 1041809000297 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1041809000298 Catalytic site [active] 1041809000299 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1041809000300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1041809000301 non-specific DNA binding site [nucleotide binding]; other site 1041809000302 salt bridge; other site 1041809000303 sequence-specific DNA binding site [nucleotide binding]; other site 1041809000304 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1041809000305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1041809000306 non-specific DNA binding site [nucleotide binding]; other site 1041809000307 salt bridge; other site 1041809000308 sequence-specific DNA binding site [nucleotide binding]; other site 1041809000309 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1041809000310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1041809000311 non-specific DNA binding site [nucleotide binding]; other site 1041809000312 salt bridge; other site 1041809000313 sequence-specific DNA binding site [nucleotide binding]; other site 1041809000314 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1041809000315 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1041809000316 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 1041809000317 active site 1041809000318 DNA binding site [nucleotide binding] 1041809000319 catalytic site [active] 1041809000320 Virulence-associated protein E; Region: VirE; pfam05272 1041809000321 VRR-NUC domain; Region: VRR_NUC; pfam08774 1041809000322 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1041809000323 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041809000324 ATP binding site [chemical binding]; other site 1041809000325 putative Mg++ binding site [ion binding]; other site 1041809000326 nucleotide binding region [chemical binding]; other site 1041809000327 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1041809000328 ATP-binding site [chemical binding]; other site 1041809000329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1041809000330 salt bridge; other site 1041809000331 non-specific DNA binding site [nucleotide binding]; other site 1041809000332 sequence-specific DNA binding site [nucleotide binding]; other site 1041809000333 Short C-terminal domain; Region: SHOCT; pfam09851 1041809000334 Terminase small subunit; Region: Terminase_2; pfam03592 1041809000335 Phage terminase large subunit; Region: Terminase_3; cl12054 1041809000336 Terminase-like family; Region: Terminase_6; pfam03237 1041809000337 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1041809000338 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1041809000339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1041809000340 salt bridge; other site 1041809000341 non-specific DNA binding site [nucleotide binding]; other site 1041809000342 sequence-specific DNA binding site [nucleotide binding]; other site 1041809000343 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1041809000344 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1041809000345 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1041809000346 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1041809000347 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1041809000348 active site 1041809000349 conformational flexibility of ligand binding pocket; other site 1041809000350 ADP-ribosylating toxin turn-turn motif; other site 1041809000351 YjcQ protein; Region: YjcQ; pfam09639 1041809000352 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1041809000353 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 1041809000354 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1041809000355 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1041809000356 Phage XkdN-like protein; Region: XkdN; pfam08890 1041809000357 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1041809000358 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1041809000359 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1041809000360 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1041809000361 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1041809000362 aconitate hydratase; Validated; Region: PRK09277 1041809000363 Holin family; Region: Phage_holin_4; pfam05105 1041809000364 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1041809000365 amidase catalytic site [active] 1041809000366 Zn binding residues [ion binding]; other site 1041809000367 substrate binding site [chemical binding]; other site 1041809000368 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809000369 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1041809000370 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1041809000371 salt bridge; other site 1041809000372 non-specific DNA binding site [nucleotide binding]; other site 1041809000373 sequence-specific DNA binding site [nucleotide binding]; other site 1041809000374 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1041809000375 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1041809000376 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1041809000377 Catalytic site [active] 1041809000378 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1041809000379 Part of AAA domain; Region: AAA_19; pfam13245 1041809000380 Family description; Region: UvrD_C_2; pfam13538 1041809000381 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1041809000382 Cation efflux family; Region: Cation_efflux; cl00316 1041809000383 aspartate kinase; Reviewed; Region: PRK06635 1041809000384 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 1041809000385 putative catalytic residues [active] 1041809000386 putative nucleotide binding site [chemical binding]; other site 1041809000387 putative aspartate binding site [chemical binding]; other site 1041809000388 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 1041809000389 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1041809000390 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1041809000391 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1041809000392 active site 1041809000393 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1041809000394 substrate binding site [chemical binding]; other site 1041809000395 catalytic residues [active] 1041809000396 dimer interface [polypeptide binding]; other site 1041809000397 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1041809000398 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1041809000399 active site 1041809000400 metal binding site [ion binding]; metal-binding site 1041809000401 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1041809000402 homotrimer interaction site [polypeptide binding]; other site 1041809000403 zinc binding site [ion binding]; other site 1041809000404 CDP-binding sites; other site 1041809000405 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1041809000406 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1041809000407 RNA binding surface [nucleotide binding]; other site 1041809000408 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1041809000409 probable active site [active] 1041809000410 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1041809000411 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1041809000412 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1041809000413 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1041809000414 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1041809000415 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1041809000416 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1041809000417 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1041809000418 HlyD family secretion protein; Region: HlyD_3; pfam13437 1041809000419 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1041809000420 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1041809000421 Walker A/P-loop; other site 1041809000422 ATP binding site [chemical binding]; other site 1041809000423 Q-loop/lid; other site 1041809000424 ABC transporter signature motif; other site 1041809000425 Walker B; other site 1041809000426 D-loop; other site 1041809000427 H-loop/switch region; other site 1041809000428 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1041809000429 FtsX-like permease family; Region: FtsX; pfam02687 1041809000430 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1041809000431 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1041809000432 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1041809000433 active site 1041809000434 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1041809000435 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1041809000436 Walker A/P-loop; other site 1041809000437 ATP binding site [chemical binding]; other site 1041809000438 Q-loop/lid; other site 1041809000439 ABC transporter signature motif; other site 1041809000440 Walker B; other site 1041809000441 D-loop; other site 1041809000442 H-loop/switch region; other site 1041809000443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1041809000444 dimer interface [polypeptide binding]; other site 1041809000445 conserved gate region; other site 1041809000446 putative PBP binding loops; other site 1041809000447 ABC-ATPase subunit interface; other site 1041809000448 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1041809000449 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1041809000450 substrate binding pocket [chemical binding]; other site 1041809000451 membrane-bound complex binding site; other site 1041809000452 hinge residues; other site 1041809000453 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1041809000454 putative active site [active] 1041809000455 catalytic site [active] 1041809000456 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1041809000457 PLD-like domain; Region: PLDc_2; pfam13091 1041809000458 putative active site [active] 1041809000459 catalytic site [active] 1041809000460 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1041809000461 beta-D-glucuronidase; Provisional; Region: PRK10150 1041809000462 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1041809000463 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1041809000464 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1041809000465 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1041809000466 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 1041809000467 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1041809000468 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4603 1041809000469 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1041809000470 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1041809000471 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1041809000472 Phosphoglycerate kinase; Region: PGK; pfam00162 1041809000473 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1041809000474 substrate binding site [chemical binding]; other site 1041809000475 hinge regions; other site 1041809000476 ADP binding site [chemical binding]; other site 1041809000477 catalytic site [active] 1041809000478 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1041809000479 triosephosphate isomerase; Provisional; Region: PRK14565 1041809000480 dimer interface [polypeptide binding]; other site 1041809000481 substrate binding site [chemical binding]; other site 1041809000482 catalytic triad [active] 1041809000483 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1041809000484 phosphoglyceromutase; Provisional; Region: PRK05434 1041809000485 enolase; Provisional; Region: eno; PRK00077 1041809000486 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1041809000487 dimer interface [polypeptide binding]; other site 1041809000488 metal binding site [ion binding]; metal-binding site 1041809000489 substrate binding pocket [chemical binding]; other site 1041809000490 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1041809000491 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1041809000492 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1041809000493 shikimate binding site; other site 1041809000494 NAD(P) binding site [chemical binding]; other site 1041809000495 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1041809000496 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1041809000497 trimer interface [polypeptide binding]; other site 1041809000498 active site 1041809000499 dimer interface [polypeptide binding]; other site 1041809000500 Chorismate mutase type II; Region: CM_2; cl00693 1041809000501 shikimate kinase; Reviewed; Region: aroK; PRK00131 1041809000502 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1041809000503 ADP binding site [chemical binding]; other site 1041809000504 magnesium binding site [ion binding]; other site 1041809000505 putative shikimate binding site; other site 1041809000506 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1041809000507 ribonuclease R; Region: RNase_R; TIGR02063 1041809000508 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1041809000509 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1041809000510 RNB domain; Region: RNB; pfam00773 1041809000511 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1041809000512 RNA binding site [nucleotide binding]; other site 1041809000513 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1041809000514 SmpB-tmRNA interface; other site 1041809000515 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1041809000516 inner membrane transporter YjeM; Provisional; Region: PRK15238 1041809000517 RibD C-terminal domain; Region: RibD_C; cl17279 1041809000518 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1041809000519 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1041809000520 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1041809000521 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1041809000522 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1041809000523 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1041809000524 active site 1041809000525 P-loop; other site 1041809000526 phosphorylation site [posttranslational modification] 1041809000527 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1041809000528 active site 1041809000529 phosphorylation site [posttranslational modification] 1041809000530 PRD domain; Region: PRD; pfam00874 1041809000531 PRD domain; Region: PRD; pfam00874 1041809000532 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1041809000533 active site 1041809000534 P-loop; other site 1041809000535 phosphorylation site [posttranslational modification] 1041809000536 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1041809000537 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1041809000538 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1041809000539 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1041809000540 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1041809000541 active site 1041809000542 metal binding site [ion binding]; metal-binding site 1041809000543 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1041809000544 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1041809000545 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1041809000546 dimerization interface [polypeptide binding]; other site 1041809000547 putative DNA binding site [nucleotide binding]; other site 1041809000548 putative Zn2+ binding site [ion binding]; other site 1041809000549 NAD synthetase; Reviewed; Region: nadE; PRK02628 1041809000550 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1041809000551 multimer interface [polypeptide binding]; other site 1041809000552 active site 1041809000553 catalytic triad [active] 1041809000554 protein interface 1 [polypeptide binding]; other site 1041809000555 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1041809000556 homodimer interface [polypeptide binding]; other site 1041809000557 NAD binding pocket [chemical binding]; other site 1041809000558 ATP binding pocket [chemical binding]; other site 1041809000559 Mg binding site [ion binding]; other site 1041809000560 active-site loop [active] 1041809000561 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1041809000562 ligand binding site [chemical binding]; other site 1041809000563 active site 1041809000564 UGI interface [polypeptide binding]; other site 1041809000565 catalytic site [active] 1041809000566 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1041809000567 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1041809000568 catalytic residue [active] 1041809000569 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1041809000570 diaminopimelate epimerase; Provisional; Region: PRK13577 1041809000571 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1041809000572 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1041809000573 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1041809000574 classical (c) SDRs; Region: SDR_c; cd05233 1041809000575 NAD(P) binding site [chemical binding]; other site 1041809000576 active site 1041809000577 TraX protein; Region: TraX; cl05434 1041809000578 AAA domain; Region: AAA_21; pfam13304 1041809000579 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1041809000580 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1041809000581 NAD(P) binding site [chemical binding]; other site 1041809000582 catalytic residues [active] 1041809000583 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1041809000584 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1041809000585 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1041809000586 active site 1041809000587 trimer interface [polypeptide binding]; other site 1041809000588 allosteric site; other site 1041809000589 active site lid [active] 1041809000590 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1041809000591 Beta propeller domain; Region: Beta_propel; pfam09826 1041809000592 spermidine synthase; Provisional; Region: PRK00811 1041809000593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041809000594 S-adenosylmethionine binding site [chemical binding]; other site 1041809000595 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 1041809000596 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1041809000597 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1041809000598 Ligand Binding Site [chemical binding]; other site 1041809000599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1041809000600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1041809000601 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1041809000602 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041809000603 active site 1041809000604 HIGH motif; other site 1041809000605 nucleotide binding site [chemical binding]; other site 1041809000606 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1041809000607 KMSKS motif; other site 1041809000608 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1041809000609 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1041809000610 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1041809000611 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1041809000612 active site 1041809000613 metal binding site [ion binding]; metal-binding site 1041809000614 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1041809000615 Catalytic site [active] 1041809000616 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 1041809000617 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1041809000618 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1041809000619 metal-binding site [ion binding] 1041809000620 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1041809000621 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1041809000622 Staphylococcal nuclease homologues; Region: SNc; smart00318 1041809000623 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1041809000624 Catalytic site; other site 1041809000625 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1041809000626 metal-binding site [ion binding] 1041809000627 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1041809000628 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041809000629 active site 1041809000630 HIGH motif; other site 1041809000631 nucleotide binding site [chemical binding]; other site 1041809000632 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1041809000633 active site 1041809000634 KMSKS motif; other site 1041809000635 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1041809000636 tRNA binding surface [nucleotide binding]; other site 1041809000637 anticodon binding site; other site 1041809000638 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1041809000639 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1041809000640 DNA binding site [nucleotide binding] 1041809000641 domain linker motif; other site 1041809000642 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1041809000643 dimerization interface [polypeptide binding]; other site 1041809000644 ligand binding site [chemical binding]; other site 1041809000645 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1041809000646 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1041809000647 phosphodiesterase; Provisional; Region: PRK12704 1041809000648 proline aminopeptidase P II; Provisional; Region: PRK10879 1041809000649 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1041809000650 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1041809000651 active site 1041809000652 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1041809000653 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1041809000654 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1041809000655 RNA binding site [nucleotide binding]; other site 1041809000656 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1041809000657 RNA binding site [nucleotide binding]; other site 1041809000658 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1041809000659 RNA binding site [nucleotide binding]; other site 1041809000660 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1041809000661 RNA binding site [nucleotide binding]; other site 1041809000662 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1041809000663 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1041809000664 metal binding site [ion binding]; metal-binding site 1041809000665 dimer interface [polypeptide binding]; other site 1041809000666 Rhomboid family; Region: Rhomboid; cl11446 1041809000667 TspO/MBR family; Region: TspO_MBR; pfam03073 1041809000668 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1041809000669 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1041809000670 active site 1041809000671 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1041809000672 RmuC family; Region: RmuC; pfam02646 1041809000673 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1041809000674 DNA polymerase I; Provisional; Region: PRK05755 1041809000675 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1041809000676 active site 1041809000677 metal binding site 1 [ion binding]; metal-binding site 1041809000678 putative 5' ssDNA interaction site; other site 1041809000679 metal binding site 3; metal-binding site 1041809000680 metal binding site 2 [ion binding]; metal-binding site 1041809000681 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1041809000682 putative DNA binding site [nucleotide binding]; other site 1041809000683 putative metal binding site [ion binding]; other site 1041809000684 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1041809000685 active site 1041809000686 substrate binding site [chemical binding]; other site 1041809000687 catalytic site [active] 1041809000688 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1041809000689 active site 1041809000690 DNA binding site [nucleotide binding] 1041809000691 catalytic site [active] 1041809000692 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1041809000693 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1041809000694 CoA-binding site [chemical binding]; other site 1041809000695 ATP-binding [chemical binding]; other site 1041809000696 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1041809000697 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1041809000698 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1041809000699 catalytic residue [active] 1041809000700 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1041809000701 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1041809000702 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1041809000703 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1041809000704 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1041809000705 NodB motif; other site 1041809000706 active site 1041809000707 catalytic site [active] 1041809000708 Zn binding site [ion binding]; other site 1041809000709 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1041809000710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041809000711 active site 1041809000712 phosphorylation site [posttranslational modification] 1041809000713 intermolecular recognition site; other site 1041809000714 dimerization interface [polypeptide binding]; other site 1041809000715 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1041809000716 DNA binding site [nucleotide binding] 1041809000717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041809000718 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1041809000719 dimerization interface [polypeptide binding]; other site 1041809000720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041809000721 dimer interface [polypeptide binding]; other site 1041809000722 phosphorylation site [posttranslational modification] 1041809000723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041809000724 ATP binding site [chemical binding]; other site 1041809000725 Mg2+ binding site [ion binding]; other site 1041809000726 G-X-G motif; other site 1041809000727 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 1041809000728 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 1041809000729 CPxP motif; other site 1041809000730 DsrE/DsrF-like family; Region: DrsE; pfam02635 1041809000731 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1041809000732 UGMP family protein; Validated; Region: PRK09604 1041809000733 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1041809000734 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1041809000735 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1041809000736 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1041809000737 protein binding site [polypeptide binding]; other site 1041809000738 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1041809000739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041809000740 Walker A/P-loop; other site 1041809000741 ATP binding site [chemical binding]; other site 1041809000742 Q-loop/lid; other site 1041809000743 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1041809000744 ABC transporter; Region: ABC_tran_2; pfam12848 1041809000745 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1041809000746 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1041809000747 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1041809000748 putative active site cavity [active] 1041809000749 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1041809000750 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1041809000751 inhibitor site; inhibition site 1041809000752 active site 1041809000753 dimer interface [polypeptide binding]; other site 1041809000754 catalytic residue [active] 1041809000755 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1041809000756 Na binding site [ion binding]; other site 1041809000757 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1041809000758 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1041809000759 nucleotide binding site [chemical binding]; other site 1041809000760 Predicted membrane protein [Function unknown]; Region: COG1971 1041809000761 ferric uptake regulator; Provisional; Region: fur; PRK09462 1041809000762 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1041809000763 metal binding site 2 [ion binding]; metal-binding site 1041809000764 putative DNA binding helix; other site 1041809000765 metal binding site 1 [ion binding]; metal-binding site 1041809000766 dimer interface [polypeptide binding]; other site 1041809000767 structural Zn2+ binding site [ion binding]; other site 1041809000768 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1041809000769 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1041809000770 ABC-ATPase subunit interface; other site 1041809000771 dimer interface [polypeptide binding]; other site 1041809000772 putative PBP binding regions; other site 1041809000773 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1041809000774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041809000775 Walker A/P-loop; other site 1041809000776 ATP binding site [chemical binding]; other site 1041809000777 Q-loop/lid; other site 1041809000778 ABC transporter signature motif; other site 1041809000779 Walker B; other site 1041809000780 D-loop; other site 1041809000781 H-loop/switch region; other site 1041809000782 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1041809000783 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1041809000784 intersubunit interface [polypeptide binding]; other site 1041809000785 Rhomboid family; Region: Rhomboid; cl11446 1041809000786 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1041809000787 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1041809000788 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1041809000789 Peptidase family M23; Region: Peptidase_M23; pfam01551 1041809000790 trigger factor; Provisional; Region: tig; PRK01490 1041809000791 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1041809000792 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1041809000793 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1041809000794 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1041809000795 oligomer interface [polypeptide binding]; other site 1041809000796 active site residues [active] 1041809000797 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1041809000798 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1041809000799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041809000800 Walker A motif; other site 1041809000801 ATP binding site [chemical binding]; other site 1041809000802 Walker B motif; other site 1041809000803 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1041809000804 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1041809000805 G1 box; other site 1041809000806 GTP/Mg2+ binding site [chemical binding]; other site 1041809000807 Switch I region; other site 1041809000808 G2 box; other site 1041809000809 G3 box; other site 1041809000810 Switch II region; other site 1041809000811 G4 box; other site 1041809000812 G5 box; other site 1041809000813 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1041809000814 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1041809000815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1041809000816 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1041809000817 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1041809000818 metal binding site [ion binding]; metal-binding site 1041809000819 dimer interface [polypeptide binding]; other site 1041809000820 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1041809000821 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1041809000822 RNA binding surface [nucleotide binding]; other site 1041809000823 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1041809000824 active site 1041809000825 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1041809000826 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1041809000827 putative phosphoesterase; Region: acc_ester; TIGR03729 1041809000828 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 1041809000829 Zn binding site [ion binding]; other site 1041809000830 V-type ATP synthase subunit I; Validated; Region: PRK05771 1041809000831 V-type ATP synthase subunit K; Validated; Region: PRK06558 1041809000832 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 1041809000833 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 1041809000834 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 1041809000835 V-type ATP synthase subunit E; Provisional; Region: PRK02292 1041809000836 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 1041809000837 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 1041809000838 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 1041809000839 V-type ATP synthase subunit A; Provisional; Region: PRK04192 1041809000840 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1041809000841 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 1041809000842 Walker A motif/ATP binding site; other site 1041809000843 Walker B motif; other site 1041809000844 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1041809000845 V-type ATP synthase subunit B; Provisional; Region: PRK04196 1041809000846 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 1041809000847 Walker A motif homologous position; other site 1041809000848 Walker B motif; other site 1041809000849 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1041809000850 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 1041809000851 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1041809000852 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1041809000853 Catalytic site [active] 1041809000854 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1041809000855 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1041809000856 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1041809000857 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1041809000858 substrate binding site [chemical binding]; other site 1041809000859 hexamer interface [polypeptide binding]; other site 1041809000860 metal binding site [ion binding]; metal-binding site 1041809000861 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1041809000862 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1041809000863 CoA binding domain; Region: CoA_binding; pfam02629 1041809000864 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1041809000865 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 1041809000866 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1041809000867 minor groove reading motif; other site 1041809000868 helix-hairpin-helix signature motif; other site 1041809000869 substrate binding pocket [chemical binding]; other site 1041809000870 active site 1041809000871 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1041809000872 pentamer interface [polypeptide binding]; other site 1041809000873 dodecaamer interface [polypeptide binding]; other site 1041809000874 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 1041809000875 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1041809000876 SdpI/YhfL protein family; Region: SdpI; pfam13630 1041809000877 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1041809000878 dimerization interface [polypeptide binding]; other site 1041809000879 putative DNA binding site [nucleotide binding]; other site 1041809000880 putative Zn2+ binding site [ion binding]; other site 1041809000881 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1041809000882 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 1041809000883 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1041809000884 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1041809000885 Hpr binding site; other site 1041809000886 active site 1041809000887 homohexamer subunit interaction site [polypeptide binding]; other site 1041809000888 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1041809000889 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1041809000890 oligomer interface [polypeptide binding]; other site 1041809000891 metal binding site [ion binding]; metal-binding site 1041809000892 metal binding site [ion binding]; metal-binding site 1041809000893 putative Cl binding site [ion binding]; other site 1041809000894 aspartate ring; other site 1041809000895 basic sphincter; other site 1041809000896 hydrophobic gate; other site 1041809000897 periplasmic entrance; other site 1041809000898 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 1041809000899 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1041809000900 oligomer interface [polypeptide binding]; other site 1041809000901 putative active site [active] 1041809000902 metal binding site [ion binding]; metal-binding site 1041809000903 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1041809000904 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1041809000905 active site 1041809000906 motif I; other site 1041809000907 motif II; other site 1041809000908 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1041809000909 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1041809000910 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1041809000911 active pocket/dimerization site; other site 1041809000912 active site 1041809000913 phosphorylation site [posttranslational modification] 1041809000914 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1041809000915 active site 1041809000916 phosphorylation site [posttranslational modification] 1041809000917 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 1041809000918 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1041809000919 Domain of unknown function (DUF956); Region: DUF956; pfam06115 1041809000920 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1041809000921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1041809000922 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1041809000923 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1041809000924 UDP-glucose 4-epimerase; Region: PLN02240 1041809000925 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1041809000926 NAD binding site [chemical binding]; other site 1041809000927 homodimer interface [polypeptide binding]; other site 1041809000928 active site 1041809000929 substrate binding site [chemical binding]; other site 1041809000930 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1041809000931 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1041809000932 HflK protein; Region: hflK; TIGR01933 1041809000933 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1041809000934 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1041809000935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041809000936 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 1041809000937 putative active site; other site 1041809000938 putative triphosphate binding site [ion binding]; other site 1041809000939 signature motif; other site 1041809000940 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1041809000941 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1041809000942 intersubunit interface [polypeptide binding]; other site 1041809000943 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1041809000944 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1041809000945 ABC-ATPase subunit interface; other site 1041809000946 dimer interface [polypeptide binding]; other site 1041809000947 putative PBP binding regions; other site 1041809000948 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1041809000949 Walker A/P-loop; other site 1041809000950 ATP binding site [chemical binding]; other site 1041809000951 ABC transporter; Region: ABC_tran; pfam00005 1041809000952 Q-loop/lid; other site 1041809000953 ABC transporter signature motif; other site 1041809000954 Walker B; other site 1041809000955 D-loop; other site 1041809000956 H-loop/switch region; other site 1041809000957 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1041809000958 Substrate-binding site [chemical binding]; other site 1041809000959 Substrate specificity [chemical binding]; other site 1041809000960 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1041809000961 AAA domain; Region: AAA_17; pfam13207 1041809000962 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1041809000963 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1041809000964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041809000965 active site 1041809000966 phosphorylation site [posttranslational modification] 1041809000967 intermolecular recognition site; other site 1041809000968 dimerization interface [polypeptide binding]; other site 1041809000969 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1041809000970 DNA binding site [nucleotide binding] 1041809000971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041809000972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041809000973 dimer interface [polypeptide binding]; other site 1041809000974 phosphorylation site [posttranslational modification] 1041809000975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041809000976 ATP binding site [chemical binding]; other site 1041809000977 Mg2+ binding site [ion binding]; other site 1041809000978 G-X-G motif; other site 1041809000979 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1041809000980 putative metal binding residues [ion binding]; other site 1041809000981 signature motif; other site 1041809000982 dimer interface [polypeptide binding]; other site 1041809000983 active site 1041809000984 polyP binding site; other site 1041809000985 substrate binding site [chemical binding]; other site 1041809000986 acceptor-phosphate pocket; other site 1041809000987 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1041809000988 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1041809000989 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1041809000990 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1041809000991 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1041809000992 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1041809000993 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1041809000994 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1041809000995 potential protein location (hypothetical protein) that overlaps protein (calcium-translocating P-type ATPase, PMCA-type) 1041809000996 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1041809000997 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1041809000998 Terminase small subunit; Region: Terminase_2; pfam03592 1041809000999 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1041809001000 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1041809001001 Phage terminase large subunit; Region: Terminase_3; cl12054 1041809001002 Terminase-like family; Region: Terminase_6; pfam03237 1041809001003 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1041809001004 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1041809001005 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1041809001006 active site 1041809001007 conformational flexibility of ligand binding pocket; other site 1041809001008 ADP-ribosylating toxin turn-turn motif; other site 1041809001009 YjcQ protein; Region: YjcQ; pfam09639 1041809001010 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 1041809001011 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 1041809001012 AAA domain; Region: AAA_21; pfam13304 1041809001013 RloB-like protein; Region: RloB; pfam13707 1041809001014 Predicted membrane protein [Function unknown]; Region: COG2364 1041809001015 Rubrerythrin [Energy production and conversion]; Region: COG1592 1041809001016 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1041809001017 binuclear metal center [ion binding]; other site 1041809001018 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 1041809001019 iron binding site [ion binding]; other site 1041809001020 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 1041809001021 thiamine-monophosphate kinase; Region: thiL; TIGR01379 1041809001022 dimerization interface [polypeptide binding]; other site 1041809001023 putative ATP binding site [chemical binding]; other site 1041809001024 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1041809001025 active site 1041809001026 dimerization interface [polypeptide binding]; other site 1041809001027 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1041809001028 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1041809001029 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1041809001030 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1041809001031 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1041809001032 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1041809001033 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1041809001034 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1041809001035 Walker A/P-loop; other site 1041809001036 ATP binding site [chemical binding]; other site 1041809001037 Q-loop/lid; other site 1041809001038 ABC transporter signature motif; other site 1041809001039 Walker B; other site 1041809001040 D-loop; other site 1041809001041 H-loop/switch region; other site 1041809001042 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1041809001043 FtsX-like permease family; Region: FtsX; pfam02687 1041809001044 Stage II sporulation protein; Region: SpoIID; pfam08486 1041809001045 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1041809001046 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1041809001047 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1041809001048 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1041809001049 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1041809001050 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1041809001051 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1041809001052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1041809001053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1041809001054 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1041809001055 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 1041809001056 active site 1041809001057 dimer interface [polypeptide binding]; other site 1041809001058 catalytic nucleophile [active] 1041809001059 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1041809001060 Predicted membrane protein [Function unknown]; Region: COG4684 1041809001061 Fumble; Region: Fumble; cl17357 1041809001062 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1041809001063 Protein of unknown function (DUF328); Region: DUF328; pfam03883 1041809001064 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1041809001065 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1041809001066 NlpC/P60 family; Region: NLPC_P60; pfam00877 1041809001067 rod shape-determining protein MreB; Provisional; Region: PRK13927 1041809001068 MreB and similar proteins; Region: MreB_like; cd10225 1041809001069 nucleotide binding site [chemical binding]; other site 1041809001070 Mg binding site [ion binding]; other site 1041809001071 putative protofilament interaction site [polypeptide binding]; other site 1041809001072 RodZ interaction site [polypeptide binding]; other site 1041809001073 rod shape-determining protein MreC; Provisional; Region: PRK13922 1041809001074 basic region leucin zipper; Region: BRLZ; smart00338 1041809001075 rod shape-determining protein MreC; Region: MreC; pfam04085 1041809001076 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1041809001077 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1041809001078 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1041809001079 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1041809001080 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1041809001081 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1041809001082 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1041809001083 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1041809001084 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1041809001085 Switch I; other site 1041809001086 Switch II; other site 1041809001087 Septum formation topological specificity factor MinE; Region: MinE; cl00538 1041809001088 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1041809001089 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1041809001090 active site 1041809001091 putative substrate binding region [chemical binding]; other site 1041809001092 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1041809001093 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1041809001094 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1041809001095 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1041809001096 GTP1/OBG; Region: GTP1_OBG; pfam01018 1041809001097 Obg GTPase; Region: Obg; cd01898 1041809001098 G1 box; other site 1041809001099 GTP/Mg2+ binding site [chemical binding]; other site 1041809001100 Switch I region; other site 1041809001101 G2 box; other site 1041809001102 G3 box; other site 1041809001103 Switch II region; other site 1041809001104 G4 box; other site 1041809001105 G5 box; other site 1041809001106 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1041809001107 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1041809001108 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1041809001109 active site 1041809001110 (T/H)XGH motif; other site 1041809001111 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1041809001112 Zn2+ binding site [ion binding]; other site 1041809001113 Mg2+ binding site [ion binding]; other site 1041809001114 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1041809001115 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1041809001116 active site 1041809001117 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1041809001118 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1041809001119 SLBB domain; Region: SLBB; pfam10531 1041809001120 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1041809001121 Helix-hairpin-helix motif; Region: HHH; pfam00633 1041809001122 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1041809001123 dimerization interface [polypeptide binding]; other site 1041809001124 ATP binding site [chemical binding]; other site 1041809001125 selenocysteine synthase; Provisional; Region: PRK04311 1041809001126 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1041809001127 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1041809001128 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1041809001129 catalytic residue [active] 1041809001130 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 1041809001131 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1041809001132 G1 box; other site 1041809001133 putative GEF interaction site [polypeptide binding]; other site 1041809001134 GTP/Mg2+ binding site [chemical binding]; other site 1041809001135 Switch I region; other site 1041809001136 G2 box; other site 1041809001137 G3 box; other site 1041809001138 Switch II region; other site 1041809001139 G4 box; other site 1041809001140 G5 box; other site 1041809001141 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1041809001142 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1041809001143 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1041809001144 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1041809001145 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1041809001146 Peptidase family M28; Region: Peptidase_M28; pfam04389 1041809001147 metal binding site [ion binding]; metal-binding site 1041809001148 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1041809001149 active site 1041809001150 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1041809001151 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1041809001152 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1041809001153 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1041809001154 active site 1041809001155 dimer interface [polypeptide binding]; other site 1041809001156 motif 1; other site 1041809001157 motif 2; other site 1041809001158 motif 3; other site 1041809001159 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1041809001160 anticodon binding site; other site 1041809001161 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1041809001162 oligomerisation interface [polypeptide binding]; other site 1041809001163 mobile loop; other site 1041809001164 roof hairpin; other site 1041809001165 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1041809001166 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1041809001167 ring oligomerisation interface [polypeptide binding]; other site 1041809001168 ATP/Mg binding site [chemical binding]; other site 1041809001169 stacking interactions; other site 1041809001170 hinge regions; other site 1041809001171 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1041809001172 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1041809001173 dimer interface [polypeptide binding]; other site 1041809001174 putative CheW interface [polypeptide binding]; other site 1041809001175 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1041809001176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1041809001177 dimer interface [polypeptide binding]; other site 1041809001178 conserved gate region; other site 1041809001179 putative PBP binding loops; other site 1041809001180 ABC-ATPase subunit interface; other site 1041809001181 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1041809001182 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1041809001183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1041809001184 dimer interface [polypeptide binding]; other site 1041809001185 conserved gate region; other site 1041809001186 putative PBP binding loops; other site 1041809001187 ABC-ATPase subunit interface; other site 1041809001188 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1041809001189 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1041809001190 Walker A/P-loop; other site 1041809001191 ATP binding site [chemical binding]; other site 1041809001192 Q-loop/lid; other site 1041809001193 ABC transporter signature motif; other site 1041809001194 Walker B; other site 1041809001195 D-loop; other site 1041809001196 H-loop/switch region; other site 1041809001197 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1041809001198 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1041809001199 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1041809001200 Walker A/P-loop; other site 1041809001201 ATP binding site [chemical binding]; other site 1041809001202 Q-loop/lid; other site 1041809001203 ABC transporter signature motif; other site 1041809001204 Walker B; other site 1041809001205 D-loop; other site 1041809001206 H-loop/switch region; other site 1041809001207 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1041809001208 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1041809001209 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1041809001210 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1041809001211 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1041809001212 Flavoprotein; Region: Flavoprotein; cl08021 1041809001213 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1041809001214 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1041809001215 folate binding site [chemical binding]; other site 1041809001216 NADP+ binding site [chemical binding]; other site 1041809001217 Thymidylate synthase [Nucleotide transport and metabolism]; Region: ThyA; COG0207 1041809001218 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1041809001219 dimerization interface [polypeptide binding]; other site 1041809001220 active site 1041809001221 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1041809001222 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1041809001223 nucleotide binding site [chemical binding]; other site 1041809001224 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1041809001225 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1041809001226 active site 1041809001227 catalytic tetrad [active] 1041809001228 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1041809001229 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1041809001230 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1041809001231 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1041809001232 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 1041809001233 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1041809001234 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1041809001235 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1041809001236 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 1041809001237 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1041809001238 active site 1041809001239 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1041809001240 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1041809001241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041809001242 active site 1041809001243 phosphorylation site [posttranslational modification] 1041809001244 intermolecular recognition site; other site 1041809001245 dimerization interface [polypeptide binding]; other site 1041809001246 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1041809001247 DNA binding site [nucleotide binding] 1041809001248 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041809001249 HAMP domain; Region: HAMP; pfam00672 1041809001250 dimerization interface [polypeptide binding]; other site 1041809001251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041809001252 dimer interface [polypeptide binding]; other site 1041809001253 phosphorylation site [posttranslational modification] 1041809001254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041809001255 ATP binding site [chemical binding]; other site 1041809001256 Mg2+ binding site [ion binding]; other site 1041809001257 G-X-G motif; other site 1041809001258 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1041809001259 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1041809001260 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 1041809001261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1041809001262 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1041809001263 Peptidase family M23; Region: Peptidase_M23; pfam01551 1041809001264 YtxC-like family; Region: YtxC; pfam08812 1041809001265 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1041809001266 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1041809001267 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1041809001268 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1041809001269 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1041809001270 23S rRNA binding site [nucleotide binding]; other site 1041809001271 L21 binding site [polypeptide binding]; other site 1041809001272 L13 binding site [polypeptide binding]; other site 1041809001273 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1041809001274 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1041809001275 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1041809001276 TrkA-N domain; Region: TrkA_N; pfam02254 1041809001277 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1041809001278 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1041809001279 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1041809001280 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1041809001281 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1041809001282 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1041809001283 dimer interface [polypeptide binding]; other site 1041809001284 motif 1; other site 1041809001285 active site 1041809001286 motif 2; other site 1041809001287 motif 3; other site 1041809001288 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1041809001289 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1041809001290 putative tRNA-binding site [nucleotide binding]; other site 1041809001291 B3/4 domain; Region: B3_4; pfam03483 1041809001292 tRNA synthetase B5 domain; Region: B5; smart00874 1041809001293 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1041809001294 dimer interface [polypeptide binding]; other site 1041809001295 motif 1; other site 1041809001296 motif 3; other site 1041809001297 motif 2; other site 1041809001298 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1041809001299 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1041809001300 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1041809001301 putative ligand binding site [chemical binding]; other site 1041809001302 putative NAD binding site [chemical binding]; other site 1041809001303 catalytic site [active] 1041809001304 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809001305 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809001306 Bacteriophage holin; Region: Phage_holin_1; cl02344 1041809001307 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1041809001308 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1041809001309 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1041809001310 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1041809001311 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1041809001312 dimer interface [polypeptide binding]; other site 1041809001313 active site 1041809001314 catalytic residue [active] 1041809001315 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1041809001316 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1041809001317 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1041809001318 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1041809001319 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1041809001320 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1041809001321 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1041809001322 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1041809001323 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1041809001324 TPP-binding site; other site 1041809001325 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1041809001326 PYR/PP interface [polypeptide binding]; other site 1041809001327 dimer interface [polypeptide binding]; other site 1041809001328 TPP binding site [chemical binding]; other site 1041809001329 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1041809001330 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 1041809001331 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1041809001332 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1041809001333 Peptidase M16C associated; Region: M16C_assoc; pfam08367 1041809001334 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1041809001335 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1041809001336 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1041809001337 substrate binding site [chemical binding]; other site 1041809001338 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1041809001339 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1041809001340 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1041809001341 active site 1041809001342 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1041809001343 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1041809001344 DHH family; Region: DHH; pfam01368 1041809001345 DHHA1 domain; Region: DHHA1; pfam02272 1041809001346 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041809001347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041809001348 dimer interface [polypeptide binding]; other site 1041809001349 phosphorylation site [posttranslational modification] 1041809001350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041809001351 ATP binding site [chemical binding]; other site 1041809001352 Mg2+ binding site [ion binding]; other site 1041809001353 G-X-G motif; other site 1041809001354 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1041809001355 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1041809001356 active site 1041809001357 homodimer interface [polypeptide binding]; other site 1041809001358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041809001359 TPR motif; other site 1041809001360 TPR repeat; Region: TPR_11; pfam13414 1041809001361 binding surface 1041809001362 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041809001363 binding surface 1041809001364 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1041809001365 TPR motif; other site 1041809001366 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809001367 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809001368 Cell division protein ZapA; Region: ZapA; pfam05164 1041809001369 Rubrerythrin [Energy production and conversion]; Region: COG1592 1041809001370 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1041809001371 binuclear metal center [ion binding]; other site 1041809001372 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 1041809001373 iron binding site [ion binding]; other site 1041809001374 Cation efflux family; Region: Cation_efflux; pfam01545 1041809001375 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1041809001376 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1041809001377 Transglycosylase; Region: Transgly; pfam00912 1041809001378 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1041809001379 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1041809001380 Peptidase family U32; Region: Peptidase_U32; pfam01136 1041809001381 Collagenase; Region: DUF3656; pfam12392 1041809001382 Peptidase family U32; Region: Peptidase_U32; cl03113 1041809001383 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1041809001384 MutS domain III; Region: MutS_III; pfam05192 1041809001385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041809001386 Walker A/P-loop; other site 1041809001387 ATP binding site [chemical binding]; other site 1041809001388 Q-loop/lid; other site 1041809001389 ABC transporter signature motif; other site 1041809001390 Walker B; other site 1041809001391 D-loop; other site 1041809001392 H-loop/switch region; other site 1041809001393 Smr domain; Region: Smr; pfam01713 1041809001394 YabP family; Region: YabP; cl06766 1041809001395 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1041809001396 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1041809001397 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1041809001398 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1041809001399 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1041809001400 Zn2+ binding site [ion binding]; other site 1041809001401 Mg2+ binding site [ion binding]; other site 1041809001402 metal-binding heat shock protein; Provisional; Region: PRK00016 1041809001403 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1041809001404 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 1041809001405 active site 1041809001406 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1041809001407 active site 1041809001408 catalytic motif [active] 1041809001409 Zn binding site [ion binding]; other site 1041809001410 GTPase Era; Reviewed; Region: era; PRK00089 1041809001411 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1041809001412 Switch II region; other site 1041809001413 G4 box; other site 1041809001414 G5 box; other site 1041809001415 KH domain; Region: KH_2; pfam07650 1041809001416 Recombination protein O N terminal; Region: RecO_N; pfam11967 1041809001417 DNA repair protein RecO; Region: reco; TIGR00613 1041809001418 Recombination protein O C terminal; Region: RecO_C; pfam02565 1041809001419 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1041809001420 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1041809001421 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1041809001422 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1041809001423 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1041809001424 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1041809001425 substrate binding site [chemical binding]; other site 1041809001426 DNA primase; Validated; Region: dnaG; PRK05667 1041809001427 CHC2 zinc finger; Region: zf-CHC2; cl17510 1041809001428 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1041809001429 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1041809001430 active site 1041809001431 metal binding site [ion binding]; metal-binding site 1041809001432 interdomain interaction site; other site 1041809001433 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1041809001434 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1041809001435 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1041809001436 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1041809001437 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1041809001438 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1041809001439 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1041809001440 DNA binding residues [nucleotide binding] 1041809001441 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1041809001442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041809001443 S-adenosylmethionine binding site [chemical binding]; other site 1041809001444 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1041809001445 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1041809001446 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1041809001447 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1041809001448 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1041809001449 active site 1041809001450 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1041809001451 Part of AAA domain; Region: AAA_19; pfam13245 1041809001452 AAA domain; Region: AAA_14; pfam13173 1041809001453 Family description; Region: UvrD_C_2; pfam13538 1041809001454 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1041809001455 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1041809001456 homodimer interface [polypeptide binding]; other site 1041809001457 substrate-cofactor binding pocket; other site 1041809001458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041809001459 catalytic residue [active] 1041809001460 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1041809001461 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1041809001462 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1041809001463 DNA binding residues [nucleotide binding] 1041809001464 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1041809001465 Microtubule-associated protein Bicaudal-D; Region: BicD; pfam09730 1041809001466 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1041809001467 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1041809001468 active site residue [active] 1041809001469 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1041809001470 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1041809001471 Beta-Casp domain; Region: Beta-Casp; smart01027 1041809001472 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1041809001473 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1041809001474 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1041809001475 dimer interface [polypeptide binding]; other site 1041809001476 PYR/PP interface [polypeptide binding]; other site 1041809001477 TPP binding site [chemical binding]; other site 1041809001478 substrate binding site [chemical binding]; other site 1041809001479 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1041809001480 Domain of unknown function; Region: EKR; smart00890 1041809001481 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1041809001482 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1041809001483 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1041809001484 TPP-binding site [chemical binding]; other site 1041809001485 dimer interface [polypeptide binding]; other site 1041809001486 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1041809001487 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1041809001488 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1041809001489 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1041809001490 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1041809001491 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 1041809001492 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1041809001493 substrate-cofactor binding pocket; other site 1041809001494 homodimer interface [polypeptide binding]; other site 1041809001495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041809001496 catalytic residue [active] 1041809001497 CheW-like domain; Region: CheW; pfam01584 1041809001498 CheD chemotactic sensory transduction; Region: CheD; cl00810 1041809001499 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1041809001500 CheB methylesterase; Region: CheB_methylest; pfam01339 1041809001501 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1041809001502 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1041809001503 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1041809001504 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1041809001505 putative binding surface; other site 1041809001506 active site 1041809001507 P2 response regulator binding domain; Region: P2; pfam07194 1041809001508 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1041809001509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041809001510 ATP binding site [chemical binding]; other site 1041809001511 Mg2+ binding site [ion binding]; other site 1041809001512 G-X-G motif; other site 1041809001513 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1041809001514 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1041809001515 CheC-like family; Region: CheC; pfam04509 1041809001516 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1041809001517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041809001518 active site 1041809001519 phosphorylation site [posttranslational modification] 1041809001520 intermolecular recognition site; other site 1041809001521 dimerization interface [polypeptide binding]; other site 1041809001522 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1041809001523 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1041809001524 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1041809001525 flagellar motor switch protein; Validated; Region: PRK08119 1041809001526 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1041809001527 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1041809001528 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1041809001529 FlgN protein; Region: FlgN; pfam05130 1041809001530 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1041809001531 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1041809001532 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1041809001533 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1041809001534 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1041809001535 FliW protein; Region: FliW; cl00740 1041809001536 carbon storage regulator; Provisional; Region: PRK01712 1041809001537 Flagellar protein FliS; Region: FliS; cl00654 1041809001538 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1041809001539 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1041809001540 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1041809001541 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1041809001542 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1041809001543 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 1041809001544 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1041809001545 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1041809001546 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1041809001547 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1041809001548 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1041809001549 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1041809001550 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 1041809001551 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1041809001552 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1041809001553 DNA binding residues [nucleotide binding] 1041809001554 putative dimer interface [polypeptide binding]; other site 1041809001555 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1041809001556 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1041809001557 active site 1041809001558 catalytic tetrad [active] 1041809001559 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1041809001560 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1041809001561 active site 1041809001562 catalytic tetrad [active] 1041809001563 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1041809001564 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1041809001565 hypothetical protein; Provisional; Region: PRK04323 1041809001566 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1041809001567 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1041809001568 catalytic site [active] 1041809001569 G-X2-G-X-G-K; other site 1041809001570 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1041809001571 primosome assembly protein PriA; Validated; Region: PRK05580 1041809001572 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041809001573 ATP binding site [chemical binding]; other site 1041809001574 putative Mg++ binding site [ion binding]; other site 1041809001575 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1041809001576 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1041809001577 active site 1041809001578 catalytic residues [active] 1041809001579 metal binding site [ion binding]; metal-binding site 1041809001580 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1041809001581 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1041809001582 putative active site [active] 1041809001583 substrate binding site [chemical binding]; other site 1041809001584 putative cosubstrate binding site; other site 1041809001585 catalytic site [active] 1041809001586 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1041809001587 substrate binding site [chemical binding]; other site 1041809001588 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1041809001589 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1041809001590 putative RNA binding site [nucleotide binding]; other site 1041809001591 NusB family; Region: NusB; pfam01029 1041809001592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041809001593 S-adenosylmethionine binding site [chemical binding]; other site 1041809001594 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 1041809001595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041809001596 FeS/SAM binding site; other site 1041809001597 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1041809001598 active site 1041809001599 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1041809001600 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1041809001601 active site 1041809001602 ATP binding site [chemical binding]; other site 1041809001603 substrate binding site [chemical binding]; other site 1041809001604 activation loop (A-loop); other site 1041809001605 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1041809001606 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1041809001607 GTPase RsgA; Reviewed; Region: PRK00098 1041809001608 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1041809001609 RNA binding site [nucleotide binding]; other site 1041809001610 homodimer interface [polypeptide binding]; other site 1041809001611 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1041809001612 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1041809001613 GTP/Mg2+ binding site [chemical binding]; other site 1041809001614 G4 box; other site 1041809001615 G5 box; other site 1041809001616 G1 box; other site 1041809001617 Switch I region; other site 1041809001618 G2 box; other site 1041809001619 G3 box; other site 1041809001620 Switch II region; other site 1041809001621 Thiamine pyrophosphokinase; Region: TPK; cd07995 1041809001622 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1041809001623 active site 1041809001624 dimerization interface [polypeptide binding]; other site 1041809001625 thiamine binding site [chemical binding]; other site 1041809001626 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1041809001627 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1041809001628 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1041809001629 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1041809001630 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1041809001631 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1041809001632 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1041809001633 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1041809001634 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1041809001635 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1041809001636 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1041809001637 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1041809001638 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1041809001639 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1041809001640 Asp23 family; Region: Asp23; cl00574 1041809001641 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1041809001642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041809001643 ATP binding site [chemical binding]; other site 1041809001644 putative Mg++ binding site [ion binding]; other site 1041809001645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041809001646 nucleotide binding region [chemical binding]; other site 1041809001647 ATP-binding site [chemical binding]; other site 1041809001648 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1041809001649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041809001650 S-adenosylmethionine binding site [chemical binding]; other site 1041809001651 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1041809001652 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1041809001653 active site 1041809001654 (T/H)XGH motif; other site 1041809001655 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1041809001656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1041809001657 active site 1041809001658 motif I; other site 1041809001659 motif II; other site 1041809001660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1041809001661 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1041809001662 Nucleoside recognition; Region: Gate; pfam07670 1041809001663 hypothetical protein; Provisional; Region: PRK13670 1041809001664 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1041809001665 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1041809001666 propionate/acetate kinase; Provisional; Region: PRK12379 1041809001667 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1041809001668 nucleotide binding site [chemical binding]; other site 1041809001669 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1041809001670 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1041809001671 putative phosphate acyltransferase; Provisional; Region: PRK05331 1041809001672 acyl carrier protein; Provisional; Region: acpP; PRK00982 1041809001673 ribonuclease III; Reviewed; Region: rnc; PRK00102 1041809001674 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1041809001675 dimerization interface [polypeptide binding]; other site 1041809001676 active site 1041809001677 metal binding site [ion binding]; metal-binding site 1041809001678 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1041809001679 dsRNA binding site [nucleotide binding]; other site 1041809001680 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1041809001681 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 1041809001682 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1041809001683 AP (apurinic/apyrimidinic) site pocket; other site 1041809001684 DNA interaction; other site 1041809001685 Metal-binding active site; metal-binding site 1041809001686 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1041809001687 HI0933-like protein; Region: HI0933_like; pfam03486 1041809001688 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1041809001689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1041809001690 cytidylate kinase; Provisional; Region: cmk; PRK00023 1041809001691 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1041809001692 CMP-binding site; other site 1041809001693 The sites determining sugar specificity; other site 1041809001694 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 1041809001695 LytB protein; Region: LYTB; cl00507 1041809001696 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1041809001697 RNA binding site [nucleotide binding]; other site 1041809001698 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1041809001699 RNA binding site [nucleotide binding]; other site 1041809001700 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1041809001701 RNA binding site [nucleotide binding]; other site 1041809001702 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1041809001703 RNA binding site [nucleotide binding]; other site 1041809001704 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 1041809001705 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 1041809001706 RNA/DNA hybrid binding site [nucleotide binding]; other site 1041809001707 active site 1041809001708 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 1041809001709 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1041809001710 active site 1041809001711 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1041809001712 GMP synthase; Reviewed; Region: guaA; PRK00074 1041809001713 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1041809001714 AMP/PPi binding site [chemical binding]; other site 1041809001715 candidate oxyanion hole; other site 1041809001716 catalytic triad [active] 1041809001717 potential glutamine specificity residues [chemical binding]; other site 1041809001718 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1041809001719 ATP Binding subdomain [chemical binding]; other site 1041809001720 Ligand Binding sites [chemical binding]; other site 1041809001721 Dimerization subdomain; other site 1041809001722 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 1041809001723 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1041809001724 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1041809001725 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1041809001726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041809001727 Q-loop/lid; other site 1041809001728 ABC transporter signature motif; other site 1041809001729 Walker B; other site 1041809001730 D-loop; other site 1041809001731 H-loop/switch region; other site 1041809001732 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1041809001733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1041809001734 dimer interface [polypeptide binding]; other site 1041809001735 conserved gate region; other site 1041809001736 putative PBP binding loops; other site 1041809001737 ABC-ATPase subunit interface; other site 1041809001738 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1041809001739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1041809001740 dimer interface [polypeptide binding]; other site 1041809001741 conserved gate region; other site 1041809001742 ABC-ATPase subunit interface; other site 1041809001743 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1041809001744 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1041809001745 active site 1041809001746 metal binding site [ion binding]; metal-binding site 1041809001747 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1041809001748 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1041809001749 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1041809001750 active site 1041809001751 catalytic tetrad [active] 1041809001752 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1041809001753 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1041809001754 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1041809001755 active site 1041809001756 phosphorylation site [posttranslational modification] 1041809001757 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1041809001758 active site 1041809001759 P-loop; other site 1041809001760 phosphorylation site [posttranslational modification] 1041809001761 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1041809001762 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1041809001763 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1041809001764 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1041809001765 putative substrate binding site [chemical binding]; other site 1041809001766 putative ATP binding site [chemical binding]; other site 1041809001767 transcription antitermination factor NusB; Region: nusB; TIGR01951 1041809001768 putative RNA binding site [nucleotide binding]; other site 1041809001769 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1041809001770 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1041809001771 generic binding surface II; other site 1041809001772 generic binding surface I; other site 1041809001773 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1041809001774 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 1041809001775 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1041809001776 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1041809001777 substrate binding pocket [chemical binding]; other site 1041809001778 chain length determination region; other site 1041809001779 substrate-Mg2+ binding site; other site 1041809001780 catalytic residues [active] 1041809001781 aspartate-rich region 1; other site 1041809001782 active site lid residues [active] 1041809001783 aspartate-rich region 2; other site 1041809001784 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1041809001785 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1041809001786 RNA binding surface [nucleotide binding]; other site 1041809001787 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1041809001788 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 1041809001789 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1041809001790 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1041809001791 arginine repressor; Provisional; Region: argR; PRK00441 1041809001792 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1041809001793 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1041809001794 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1041809001795 Walker A/P-loop; other site 1041809001796 ATP binding site [chemical binding]; other site 1041809001797 Q-loop/lid; other site 1041809001798 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1041809001799 ABC transporter signature motif; other site 1041809001800 Walker B; other site 1041809001801 D-loop; other site 1041809001802 H-loop/switch region; other site 1041809001803 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1041809001804 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1041809001805 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1041809001806 Response regulator receiver domain; Region: Response_reg; pfam00072 1041809001807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041809001808 active site 1041809001809 phosphorylation site [posttranslational modification] 1041809001810 intermolecular recognition site; other site 1041809001811 dimerization interface [polypeptide binding]; other site 1041809001812 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1041809001813 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1041809001814 intersubunit interface [polypeptide binding]; other site 1041809001815 active site 1041809001816 catalytic residue [active] 1041809001817 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1041809001818 active site 1041809001819 catalytic triad [active] 1041809001820 oxyanion hole [active] 1041809001821 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1041809001822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041809001823 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1041809001824 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1041809001825 ABC transporter signature motif; other site 1041809001826 Walker B; other site 1041809001827 D-loop; other site 1041809001828 H-loop/switch region; other site 1041809001829 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1041809001830 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1041809001831 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1041809001832 P loop; other site 1041809001833 GTP binding site [chemical binding]; other site 1041809001834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1041809001835 signal recognition particle protein; Provisional; Region: PRK10867 1041809001836 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1041809001837 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1041809001838 P loop; other site 1041809001839 GTP binding site [chemical binding]; other site 1041809001840 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1041809001841 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1041809001842 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1041809001843 RimM N-terminal domain; Region: RimM; pfam01782 1041809001844 PRC-barrel domain; Region: PRC; pfam05239 1041809001845 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1041809001846 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1041809001847 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1041809001848 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1041809001849 GTP/Mg2+ binding site [chemical binding]; other site 1041809001850 G4 box; other site 1041809001851 G5 box; other site 1041809001852 G1 box; other site 1041809001853 Switch I region; other site 1041809001854 G2 box; other site 1041809001855 G3 box; other site 1041809001856 Switch II region; other site 1041809001857 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1041809001858 RNA/DNA hybrid binding site [nucleotide binding]; other site 1041809001859 active site 1041809001860 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1041809001861 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1041809001862 putative active site [active] 1041809001863 putative FMN binding site [chemical binding]; other site 1041809001864 putative substrate binding site [chemical binding]; other site 1041809001865 putative catalytic residue [active] 1041809001866 hypothetical protein; Reviewed; Region: PRK12497 1041809001867 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1041809001868 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1041809001869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1041809001870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1041809001871 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1041809001872 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1041809001873 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1041809001874 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1041809001875 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1041809001876 ligand binding site [chemical binding]; other site 1041809001877 dimerization interface [polypeptide binding]; other site 1041809001878 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1041809001879 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1041809001880 TM-ABC transporter signature motif; other site 1041809001881 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1041809001882 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1041809001883 Walker A/P-loop; other site 1041809001884 ATP binding site [chemical binding]; other site 1041809001885 Q-loop/lid; other site 1041809001886 ABC transporter signature motif; other site 1041809001887 Walker B; other site 1041809001888 D-loop; other site 1041809001889 H-loop/switch region; other site 1041809001890 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1041809001891 D-ribose pyranase; Provisional; Region: PRK11797 1041809001892 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1041809001893 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1041809001894 substrate binding site [chemical binding]; other site 1041809001895 dimer interface [polypeptide binding]; other site 1041809001896 ATP binding site [chemical binding]; other site 1041809001897 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1041809001898 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1041809001899 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1041809001900 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1041809001901 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 1041809001902 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 1041809001903 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1041809001904 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1041809001905 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1041809001906 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1041809001907 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1041809001908 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1041809001909 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 1041809001910 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1041809001911 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1041809001912 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1041809001913 HPr interaction site; other site 1041809001914 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1041809001915 active site 1041809001916 phosphorylation site [posttranslational modification] 1041809001917 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1041809001918 beta-galactosidase; Region: BGL; TIGR03356 1041809001919 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 1041809001920 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1041809001921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1041809001922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1041809001923 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1041809001924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1041809001925 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1041809001926 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1041809001927 active site turn [active] 1041809001928 phosphorylation site [posttranslational modification] 1041809001929 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1041809001930 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1041809001931 HPr interaction site; other site 1041809001932 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1041809001933 active site 1041809001934 phosphorylation site [posttranslational modification] 1041809001935 CAT RNA binding domain; Region: CAT_RBD; smart01061 1041809001936 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1041809001937 PRD domain; Region: PRD; pfam00874 1041809001938 PRD domain; Region: PRD; pfam00874 1041809001939 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1041809001940 HTH domain; Region: HTH_11; pfam08279 1041809001941 PRD domain; Region: PRD; pfam00874 1041809001942 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1041809001943 active site 1041809001944 P-loop; other site 1041809001945 phosphorylation site [posttranslational modification] 1041809001946 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1041809001947 active site 1041809001948 catalytic residues [active] 1041809001949 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1041809001950 active site 1041809001951 phosphorylation site [posttranslational modification] 1041809001952 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1041809001953 active site 1041809001954 phosphorylation site [posttranslational modification] 1041809001955 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1041809001956 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1041809001957 active site 1041809001958 P-loop; other site 1041809001959 phosphorylation site [posttranslational modification] 1041809001960 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1041809001961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041809001962 S-adenosylmethionine binding site [chemical binding]; other site 1041809001963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1041809001964 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1041809001965 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1041809001966 putative active site [active] 1041809001967 catalytic site [active] 1041809001968 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1041809001969 putative active site [active] 1041809001970 catalytic site [active] 1041809001971 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1041809001972 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1041809001973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041809001974 Walker A motif; other site 1041809001975 ATP binding site [chemical binding]; other site 1041809001976 Walker B motif; other site 1041809001977 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1041809001978 DNA protecting protein DprA; Region: dprA; TIGR00732 1041809001979 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1041809001980 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1041809001981 putative DNA binding site [nucleotide binding]; other site 1041809001982 dimerization interface [polypeptide binding]; other site 1041809001983 putative Zn2+ binding site [ion binding]; other site 1041809001984 DNA topoisomerase I; Validated; Region: PRK05582 1041809001985 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1041809001986 active site 1041809001987 metal binding site [ion binding]; metal-binding site 1041809001988 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1041809001989 domain I; other site 1041809001990 DNA binding groove [nucleotide binding] 1041809001991 phosphate binding site [ion binding]; other site 1041809001992 domain II; other site 1041809001993 domain III; other site 1041809001994 nucleotide binding site [chemical binding]; other site 1041809001995 catalytic site [active] 1041809001996 domain IV; other site 1041809001997 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1041809001998 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1041809001999 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1041809002000 rRNA interaction site [nucleotide binding]; other site 1041809002001 S8 interaction site; other site 1041809002002 putative laminin-1 binding site; other site 1041809002003 elongation factor Ts; Provisional; Region: tsf; PRK09377 1041809002004 UBA/TS-N domain; Region: UBA; pfam00627 1041809002005 Elongation factor TS; Region: EF_TS; pfam00889 1041809002006 Elongation factor TS; Region: EF_TS; pfam00889 1041809002007 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1041809002008 putative nucleotide binding site [chemical binding]; other site 1041809002009 uridine monophosphate binding site [chemical binding]; other site 1041809002010 homohexameric interface [polypeptide binding]; other site 1041809002011 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1041809002012 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1041809002013 hinge region; other site 1041809002014 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1041809002015 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1041809002016 catalytic residue [active] 1041809002017 putative FPP diphosphate binding site; other site 1041809002018 putative FPP binding hydrophobic cleft; other site 1041809002019 dimer interface [polypeptide binding]; other site 1041809002020 putative IPP diphosphate binding site; other site 1041809002021 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1041809002022 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1041809002023 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1041809002024 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1041809002025 active site 1041809002026 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1041809002027 protein binding site [polypeptide binding]; other site 1041809002028 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1041809002029 putative substrate binding region [chemical binding]; other site 1041809002030 GcpE protein; Region: GcpE; pfam04551 1041809002031 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1041809002032 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1041809002033 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1041809002034 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1041809002035 generic binding surface II; other site 1041809002036 generic binding surface I; other site 1041809002037 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1041809002038 active site 1041809002039 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1041809002040 active site 1041809002041 catalytic site [active] 1041809002042 substrate binding site [chemical binding]; other site 1041809002043 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1041809002044 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1041809002045 Sm and related proteins; Region: Sm_like; cl00259 1041809002046 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1041809002047 putative oligomer interface [polypeptide binding]; other site 1041809002048 putative RNA binding site [nucleotide binding]; other site 1041809002049 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1041809002050 NusA N-terminal domain; Region: NusA_N; pfam08529 1041809002051 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1041809002052 RNA binding site [nucleotide binding]; other site 1041809002053 homodimer interface [polypeptide binding]; other site 1041809002054 NusA-like KH domain; Region: KH_5; pfam13184 1041809002055 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1041809002056 G-X-X-G motif; other site 1041809002057 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1041809002058 putative RNA binding cleft [nucleotide binding]; other site 1041809002059 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1041809002060 translation initiation factor IF-2; Region: IF-2; TIGR00487 1041809002061 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1041809002062 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1041809002063 G1 box; other site 1041809002064 putative GEF interaction site [polypeptide binding]; other site 1041809002065 GTP/Mg2+ binding site [chemical binding]; other site 1041809002066 Switch I region; other site 1041809002067 G2 box; other site 1041809002068 G3 box; other site 1041809002069 Switch II region; other site 1041809002070 G4 box; other site 1041809002071 G5 box; other site 1041809002072 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1041809002073 Translation-initiation factor 2; Region: IF-2; pfam11987 1041809002074 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1041809002075 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1041809002076 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1041809002077 DHH family; Region: DHH; pfam01368 1041809002078 DHHA1 domain; Region: DHHA1; pfam02272 1041809002079 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 1041809002080 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1041809002081 RNA binding site [nucleotide binding]; other site 1041809002082 active site 1041809002083 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1041809002084 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1041809002085 active site 1041809002086 Riboflavin kinase; Region: Flavokinase; pfam01687 1041809002087 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1041809002088 16S/18S rRNA binding site [nucleotide binding]; other site 1041809002089 S13e-L30e interaction site [polypeptide binding]; other site 1041809002090 25S rRNA binding site [nucleotide binding]; other site 1041809002091 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1041809002092 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1041809002093 RNase E interface [polypeptide binding]; other site 1041809002094 trimer interface [polypeptide binding]; other site 1041809002095 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1041809002096 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1041809002097 RNase E interface [polypeptide binding]; other site 1041809002098 trimer interface [polypeptide binding]; other site 1041809002099 active site 1041809002100 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1041809002101 RNA binding site [nucleotide binding]; other site 1041809002102 domain interface; other site 1041809002103 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 1041809002104 aspartate kinase I; Reviewed; Region: PRK08210 1041809002105 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1041809002106 nucleotide binding site [chemical binding]; other site 1041809002107 substrate binding site [chemical binding]; other site 1041809002108 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1041809002109 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1041809002110 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1041809002111 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1041809002112 active site 1041809002113 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1041809002114 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1041809002115 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1041809002116 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1041809002117 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1041809002118 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1041809002119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041809002120 FeS/SAM binding site; other site 1041809002121 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1041809002122 recombinase A; Provisional; Region: recA; PRK09354 1041809002123 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1041809002124 hexamer interface [polypeptide binding]; other site 1041809002125 Walker A motif; other site 1041809002126 ATP binding site [chemical binding]; other site 1041809002127 Walker B motif; other site 1041809002128 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1041809002129 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1041809002130 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1041809002131 Zn2+ binding site [ion binding]; other site 1041809002132 Mg2+ binding site [ion binding]; other site 1041809002133 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1041809002134 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1041809002135 dimerization domain swap beta strand [polypeptide binding]; other site 1041809002136 regulatory protein interface [polypeptide binding]; other site 1041809002137 active site 1041809002138 regulatory phosphorylation site [posttranslational modification]; other site 1041809002139 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1041809002140 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1041809002141 active site 1041809002142 DNA binding site [nucleotide binding] 1041809002143 Int/Topo IB signature motif; other site 1041809002144 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1041809002145 Aluminium resistance protein; Region: Alum_res; pfam06838 1041809002146 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1041809002147 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1041809002148 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1041809002149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041809002150 ATP binding site [chemical binding]; other site 1041809002151 Mg2+ binding site [ion binding]; other site 1041809002152 G-X-G motif; other site 1041809002153 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1041809002154 ATP binding site [chemical binding]; other site 1041809002155 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1041809002156 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1041809002157 MutS domain I; Region: MutS_I; pfam01624 1041809002158 MutS domain II; Region: MutS_II; pfam05188 1041809002159 MutS domain III; Region: MutS_III; pfam05192 1041809002160 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1041809002161 Walker A/P-loop; other site 1041809002162 ATP binding site [chemical binding]; other site 1041809002163 Q-loop/lid; other site 1041809002164 ABC transporter signature motif; other site 1041809002165 Walker B; other site 1041809002166 D-loop; other site 1041809002167 H-loop/switch region; other site 1041809002168 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 1041809002169 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1041809002170 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1041809002171 FeS/SAM binding site; other site 1041809002172 TRAM domain; Region: TRAM; pfam01938 1041809002173 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1041809002174 active site 1041809002175 catalytic site [active] 1041809002176 Predicted transcriptional regulators [Transcription]; Region: COG1725 1041809002177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1041809002178 DNA-binding site [nucleotide binding]; DNA binding site 1041809002179 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1041809002180 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1041809002181 Walker A/P-loop; other site 1041809002182 ATP binding site [chemical binding]; other site 1041809002183 Q-loop/lid; other site 1041809002184 ABC transporter signature motif; other site 1041809002185 Walker B; other site 1041809002186 D-loop; other site 1041809002187 H-loop/switch region; other site 1041809002188 aspartate aminotransferase; Provisional; Region: PRK07568 1041809002189 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1041809002190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041809002191 homodimer interface [polypeptide binding]; other site 1041809002192 catalytic residue [active] 1041809002193 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1041809002194 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1041809002195 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041809002196 active site 1041809002197 putative hydrolase; Validated; Region: PRK09248 1041809002198 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1041809002199 active site 1041809002200 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1041809002201 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1041809002202 gating phenylalanine in ion channel; other site 1041809002203 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1041809002204 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1041809002205 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 1041809002206 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 1041809002207 putative active site [active] 1041809002208 FOG: PKD repeat [General function prediction only]; Region: COG3291 1041809002209 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1041809002210 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1041809002211 sugar binding site [chemical binding]; other site 1041809002212 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1041809002213 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1041809002214 nucleotide binding site [chemical binding]; other site 1041809002215 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1041809002216 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1041809002217 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1041809002218 Walker A/P-loop; other site 1041809002219 ATP binding site [chemical binding]; other site 1041809002220 Q-loop/lid; other site 1041809002221 ABC transporter signature motif; other site 1041809002222 Walker B; other site 1041809002223 D-loop; other site 1041809002224 H-loop/switch region; other site 1041809002225 Predicted membrane protein [Function unknown]; Region: COG3428 1041809002226 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1041809002227 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1041809002228 nucleotide binding site [chemical binding]; other site 1041809002229 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1041809002230 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1041809002231 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1041809002232 active site 1041809002233 catalytic site [active] 1041809002234 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 1041809002235 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1041809002236 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1041809002237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1041809002238 dimer interface [polypeptide binding]; other site 1041809002239 conserved gate region; other site 1041809002240 ABC-ATPase subunit interface; other site 1041809002241 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1041809002242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1041809002243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1041809002244 ABC-ATPase subunit interface; other site 1041809002245 Response regulator receiver domain; Region: Response_reg; pfam00072 1041809002246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041809002247 active site 1041809002248 phosphorylation site [posttranslational modification] 1041809002249 intermolecular recognition site; other site 1041809002250 dimerization interface [polypeptide binding]; other site 1041809002251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1041809002252 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1041809002253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1041809002254 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1041809002255 dimerization interface [polypeptide binding]; other site 1041809002256 Histidine kinase; Region: His_kinase; pfam06580 1041809002257 Uncharacterized conserved protein [Function unknown]; Region: COG3538 1041809002258 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1041809002259 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1041809002260 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1041809002261 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1041809002262 trimer interface [polypeptide binding]; other site 1041809002263 active site 1041809002264 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1041809002265 catalytic site [active] 1041809002266 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1041809002267 predicted active site [active] 1041809002268 catalytic triad [active] 1041809002269 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1041809002270 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1041809002271 active site 1041809002272 multimer interface [polypeptide binding]; other site 1041809002273 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1041809002274 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1041809002275 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041809002276 ATP binding site [chemical binding]; other site 1041809002277 putative Mg++ binding site [ion binding]; other site 1041809002278 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1041809002279 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1041809002280 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1041809002281 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 1041809002282 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1041809002283 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1041809002284 AAA domain; Region: AAA_13; pfam13166 1041809002285 HpaII restriction endonuclease; Region: RE_HpaII; pfam09561 1041809002286 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1041809002287 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 1041809002288 cofactor binding site; other site 1041809002289 DNA binding site [nucleotide binding] 1041809002290 substrate interaction site [chemical binding]; other site 1041809002291 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1041809002292 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1041809002293 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1041809002294 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1041809002295 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1041809002296 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1041809002297 GTP-binding protein Der; Reviewed; Region: PRK00093 1041809002298 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1041809002299 G1 box; other site 1041809002300 GTP/Mg2+ binding site [chemical binding]; other site 1041809002301 Switch I region; other site 1041809002302 G2 box; other site 1041809002303 Switch II region; other site 1041809002304 G3 box; other site 1041809002305 G4 box; other site 1041809002306 G5 box; other site 1041809002307 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1041809002308 G1 box; other site 1041809002309 GTP/Mg2+ binding site [chemical binding]; other site 1041809002310 Switch I region; other site 1041809002311 G2 box; other site 1041809002312 G3 box; other site 1041809002313 Switch II region; other site 1041809002314 G4 box; other site 1041809002315 G5 box; other site 1041809002316 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 1041809002317 Peptidase family M28; Region: Peptidase_M28; pfam04389 1041809002318 metal binding site [ion binding]; metal-binding site 1041809002319 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1041809002320 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1041809002321 non-specific DNA binding site [nucleotide binding]; other site 1041809002322 salt bridge; other site 1041809002323 sequence-specific DNA binding site [nucleotide binding]; other site 1041809002324 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1041809002325 amidase catalytic site [active] 1041809002326 Zn binding residues [ion binding]; other site 1041809002327 substrate binding site [chemical binding]; other site 1041809002328 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809002329 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1041809002330 PhoU domain; Region: PhoU; pfam01895 1041809002331 PhoU domain; Region: PhoU; pfam01895 1041809002332 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1041809002333 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1041809002334 Walker A/P-loop; other site 1041809002335 ATP binding site [chemical binding]; other site 1041809002336 Q-loop/lid; other site 1041809002337 ABC transporter signature motif; other site 1041809002338 Walker B; other site 1041809002339 D-loop; other site 1041809002340 H-loop/switch region; other site 1041809002341 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1041809002342 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1041809002343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1041809002344 dimer interface [polypeptide binding]; other site 1041809002345 conserved gate region; other site 1041809002346 putative PBP binding loops; other site 1041809002347 ABC-ATPase subunit interface; other site 1041809002348 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1041809002349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1041809002350 dimer interface [polypeptide binding]; other site 1041809002351 conserved gate region; other site 1041809002352 putative PBP binding loops; other site 1041809002353 ABC-ATPase subunit interface; other site 1041809002354 PBP superfamily domain; Region: PBP_like_2; cl17296 1041809002355 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1041809002356 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041809002357 dimer interface [polypeptide binding]; other site 1041809002358 phosphorylation site [posttranslational modification] 1041809002359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041809002360 ATP binding site [chemical binding]; other site 1041809002361 Mg2+ binding site [ion binding]; other site 1041809002362 G-X-G motif; other site 1041809002363 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1041809002364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041809002365 active site 1041809002366 phosphorylation site [posttranslational modification] 1041809002367 intermolecular recognition site; other site 1041809002368 dimerization interface [polypeptide binding]; other site 1041809002369 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1041809002370 DNA binding site [nucleotide binding] 1041809002371 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1041809002372 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 1041809002373 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1041809002374 Heavy-metal-associated domain; Region: HMA; pfam00403 1041809002375 metal-binding site [ion binding] 1041809002376 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1041809002377 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1041809002378 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1041809002379 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1041809002380 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1041809002381 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1041809002382 DNA binding residues [nucleotide binding] 1041809002383 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1041809002384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1041809002385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1041809002386 DNA binding residues [nucleotide binding] 1041809002387 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1041809002388 cell division protein FtsZ; Validated; Region: PRK09330 1041809002389 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1041809002390 nucleotide binding site [chemical binding]; other site 1041809002391 SulA interaction site; other site 1041809002392 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1041809002393 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1041809002394 DXD motif; other site 1041809002395 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 1041809002396 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1041809002397 Walker A motif; other site 1041809002398 ATP binding site [chemical binding]; other site 1041809002399 Walker B motif; other site 1041809002400 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1041809002401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1041809002402 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1041809002403 DNA binding residues [nucleotide binding] 1041809002404 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1041809002405 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1041809002406 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1041809002407 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1041809002408 Peptidase family U32; Region: Peptidase_U32; pfam01136 1041809002409 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1041809002410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041809002411 S-adenosylmethionine binding site [chemical binding]; other site 1041809002412 YceG-like family; Region: YceG; pfam02618 1041809002413 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1041809002414 dimerization interface [polypeptide binding]; other site 1041809002415 Protein of unknown function (DUF964); Region: DUF964; cl01483 1041809002416 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1041809002417 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1041809002418 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1041809002419 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1041809002420 metal binding site 2 [ion binding]; metal-binding site 1041809002421 putative DNA binding helix; other site 1041809002422 metal binding site 1 [ion binding]; metal-binding site 1041809002423 dimer interface [polypeptide binding]; other site 1041809002424 structural Zn2+ binding site [ion binding]; other site 1041809002425 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1041809002426 hypothetical protein; Provisional; Region: PRK05473 1041809002427 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1041809002428 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1041809002429 motif 1; other site 1041809002430 active site 1041809002431 motif 2; other site 1041809002432 motif 3; other site 1041809002433 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1041809002434 DHHA1 domain; Region: DHHA1; pfam02272 1041809002435 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1041809002436 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1041809002437 Ligand Binding Site [chemical binding]; other site 1041809002438 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1041809002439 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1041809002440 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1041809002441 catalytic residue [active] 1041809002442 Predicted transcriptional regulator [Transcription]; Region: COG1959 1041809002443 Transcriptional regulator; Region: Rrf2; cl17282 1041809002444 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1041809002445 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1041809002446 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1041809002447 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1041809002448 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1041809002449 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1041809002450 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1041809002451 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1041809002452 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 1041809002453 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1041809002454 carboxyltransferase (CT) interaction site; other site 1041809002455 biotinylation site [posttranslational modification]; other site 1041809002456 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1041809002457 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1041809002458 dimer interface [polypeptide binding]; other site 1041809002459 active site 1041809002460 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1041809002461 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1041809002462 NAD(P) binding site [chemical binding]; other site 1041809002463 homotetramer interface [polypeptide binding]; other site 1041809002464 homodimer interface [polypeptide binding]; other site 1041809002465 active site 1041809002466 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1041809002467 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1041809002468 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1041809002469 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1041809002470 dimer interface [polypeptide binding]; other site 1041809002471 active site 1041809002472 CoA binding pocket [chemical binding]; other site 1041809002473 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1041809002474 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1041809002475 dimer interface [polypeptide binding]; other site 1041809002476 active site 1041809002477 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1041809002478 folate binding site [chemical binding]; other site 1041809002479 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1041809002480 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1041809002481 dimer interface [polypeptide binding]; other site 1041809002482 anticodon binding site; other site 1041809002483 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1041809002484 homodimer interface [polypeptide binding]; other site 1041809002485 motif 1; other site 1041809002486 active site 1041809002487 motif 2; other site 1041809002488 GAD domain; Region: GAD; pfam02938 1041809002489 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1041809002490 active site 1041809002491 motif 3; other site 1041809002492 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1041809002493 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1041809002494 dimer interface [polypeptide binding]; other site 1041809002495 motif 1; other site 1041809002496 active site 1041809002497 motif 2; other site 1041809002498 motif 3; other site 1041809002499 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1041809002500 anticodon binding site; other site 1041809002501 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1041809002502 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1041809002503 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1041809002504 Zn2+ binding site [ion binding]; other site 1041809002505 Mg2+ binding site [ion binding]; other site 1041809002506 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1041809002507 synthetase active site [active] 1041809002508 NTP binding site [chemical binding]; other site 1041809002509 metal binding site [ion binding]; metal-binding site 1041809002510 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1041809002511 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1041809002512 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041809002513 active site 1041809002514 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1041809002515 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1041809002516 Protein export membrane protein; Region: SecD_SecF; pfam02355 1041809002517 protein-export membrane protein SecD; Region: secD; TIGR01129 1041809002518 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1041809002519 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 1041809002520 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041809002521 FeS/SAM binding site; other site 1041809002522 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1041809002523 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 1041809002524 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809002525 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1041809002526 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1041809002527 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1041809002528 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1041809002529 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1041809002530 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1041809002531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041809002532 Walker A motif; other site 1041809002533 ATP binding site [chemical binding]; other site 1041809002534 Walker B motif; other site 1041809002535 arginine finger; other site 1041809002536 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1041809002537 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1041809002538 RuvA N terminal domain; Region: RuvA_N; pfam01330 1041809002539 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1041809002540 hypothetical protein; Validated; Region: PRK00110 1041809002541 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1041809002542 homodimer interface [polypeptide binding]; other site 1041809002543 oligomer interface [polypeptide binding]; other site 1041809002544 chemical substrate binding site [chemical binding]; other site 1041809002545 metal binding site [ion binding]; metal-binding site 1041809002546 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1041809002547 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1041809002548 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1041809002549 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1041809002550 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1041809002551 HflX GTPase family; Region: HflX; cd01878 1041809002552 G1 box; other site 1041809002553 GTP/Mg2+ binding site [chemical binding]; other site 1041809002554 Switch I region; other site 1041809002555 G2 box; other site 1041809002556 G3 box; other site 1041809002557 Switch II region; other site 1041809002558 G4 box; other site 1041809002559 G5 box; other site 1041809002560 Transglycosylase; Region: Transgly; pfam00912 1041809002561 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1041809002562 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1041809002563 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1041809002564 active site 1041809002565 metal binding site [ion binding]; metal-binding site 1041809002566 homotetramer interface [polypeptide binding]; other site 1041809002567 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1041809002568 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1041809002569 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1041809002570 homodimer interface [polypeptide binding]; other site 1041809002571 NADP binding site [chemical binding]; other site 1041809002572 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1041809002573 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1041809002574 active site 1041809002575 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1041809002576 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041809002577 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1041809002578 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1041809002579 NodB motif; other site 1041809002580 active site 1041809002581 catalytic site [active] 1041809002582 Zn binding site [ion binding]; other site 1041809002583 Predicted permease; Region: DUF318; cl17795 1041809002584 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1041809002585 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1041809002586 dimerization interface [polypeptide binding]; other site 1041809002587 domain crossover interface; other site 1041809002588 redox-dependent activation switch; other site 1041809002589 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1041809002590 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1041809002591 protein binding site [polypeptide binding]; other site 1041809002592 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1041809002593 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1041809002594 dimer interface [polypeptide binding]; other site 1041809002595 active site 1041809002596 metal binding site [ion binding]; metal-binding site 1041809002597 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1041809002598 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1041809002599 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1041809002600 RNA binding surface [nucleotide binding]; other site 1041809002601 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1041809002602 active site 1041809002603 DivIVA protein; Region: DivIVA; pfam05103 1041809002604 DivIVA domain; Region: DivI1A_domain; TIGR03544 1041809002605 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1041809002606 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1041809002607 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1041809002608 RNA binding surface [nucleotide binding]; other site 1041809002609 Protein of unknown function (DUF552); Region: DUF552; cl00775 1041809002610 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1041809002611 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1041809002612 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1041809002613 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1041809002614 Mg++ binding site [ion binding]; other site 1041809002615 putative catalytic motif [active] 1041809002616 putative substrate binding site [chemical binding]; other site 1041809002617 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1041809002618 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1041809002619 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1041809002620 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1041809002621 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1041809002622 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1041809002623 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1041809002624 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1041809002625 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1041809002626 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1041809002627 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1041809002628 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1041809002629 MraW methylase family; Region: Methyltransf_5; cl17771 1041809002630 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1041809002631 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1041809002632 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1041809002633 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1041809002634 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1041809002635 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1041809002636 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1041809002637 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1041809002638 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1041809002639 Walker A/P-loop; other site 1041809002640 ATP binding site [chemical binding]; other site 1041809002641 Q-loop/lid; other site 1041809002642 ABC transporter signature motif; other site 1041809002643 Walker B; other site 1041809002644 D-loop; other site 1041809002645 H-loop/switch region; other site 1041809002646 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1041809002647 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1041809002648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041809002649 Walker A/P-loop; other site 1041809002650 ATP binding site [chemical binding]; other site 1041809002651 Q-loop/lid; other site 1041809002652 ABC transporter signature motif; other site 1041809002653 Walker B; other site 1041809002654 D-loop; other site 1041809002655 H-loop/switch region; other site 1041809002656 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1041809002657 catalytic loop [active] 1041809002658 iron binding site [ion binding]; other site 1041809002659 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1041809002660 4Fe-4S binding domain; Region: Fer4; cl02805 1041809002661 4Fe-4S binding domain; Region: Fer4; pfam00037 1041809002662 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1041809002663 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 1041809002664 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 1041809002665 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1041809002666 G1 box; other site 1041809002667 GTP/Mg2+ binding site [chemical binding]; other site 1041809002668 Switch I region; other site 1041809002669 G2 box; other site 1041809002670 Switch II region; other site 1041809002671 G3 box; other site 1041809002672 G4 box; other site 1041809002673 G5 box; other site 1041809002674 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 1041809002675 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041809002676 FeS/SAM binding site; other site 1041809002677 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1041809002678 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 1041809002679 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041809002680 FeS/SAM binding site; other site 1041809002681 GTP-binding protein YchF; Reviewed; Region: PRK09601 1041809002682 YchF GTPase; Region: YchF; cd01900 1041809002683 G1 box; other site 1041809002684 GTP/Mg2+ binding site [chemical binding]; other site 1041809002685 Switch I region; other site 1041809002686 G2 box; other site 1041809002687 Switch II region; other site 1041809002688 G3 box; other site 1041809002689 G4 box; other site 1041809002690 G5 box; other site 1041809002691 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1041809002692 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1041809002693 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1041809002694 NodB motif; other site 1041809002695 active site 1041809002696 catalytic site [active] 1041809002697 Cd binding site [ion binding]; other site 1041809002698 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1041809002699 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041809002700 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1041809002701 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1041809002702 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1041809002703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041809002704 TPR motif; other site 1041809002705 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1041809002706 binding surface 1041809002707 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1041809002708 active site 1041809002709 substrate binding site [chemical binding]; other site 1041809002710 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1041809002711 metal binding site [ion binding]; metal-binding site 1041809002712 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1041809002713 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1041809002714 5S rRNA interface [nucleotide binding]; other site 1041809002715 CTC domain interface [polypeptide binding]; other site 1041809002716 L16 interface [polypeptide binding]; other site 1041809002717 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1041809002718 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1041809002719 homodimer interface [polypeptide binding]; other site 1041809002720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041809002721 catalytic residue [active] 1041809002722 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1041809002723 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1041809002724 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809002725 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809002726 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809002727 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809002728 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1041809002729 nucleotide binding site/active site [active] 1041809002730 HIT family signature motif; other site 1041809002731 catalytic residue [active] 1041809002732 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1041809002733 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1041809002734 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041809002735 FeS/SAM binding site; other site 1041809002736 TRAM domain; Region: TRAM; cl01282 1041809002737 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1041809002738 RNA methyltransferase, RsmE family; Region: TIGR00046 1041809002739 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 1041809002740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041809002741 S-adenosylmethionine binding site [chemical binding]; other site 1041809002742 HIRAN domain; Region: HIRAN; cl07418 1041809002743 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1041809002744 Dynamin family; Region: Dynamin_N; pfam00350 1041809002745 G1 box; other site 1041809002746 GTP/Mg2+ binding site [chemical binding]; other site 1041809002747 G2 box; other site 1041809002748 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1041809002749 G3 box; other site 1041809002750 Switch II region; other site 1041809002751 GTP/Mg2+ binding site [chemical binding]; other site 1041809002752 G4 box; other site 1041809002753 G5 box; other site 1041809002754 recombination factor protein RarA; Reviewed; Region: PRK13342 1041809002755 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041809002756 Walker A motif; other site 1041809002757 ATP binding site [chemical binding]; other site 1041809002758 Walker B motif; other site 1041809002759 arginine finger; other site 1041809002760 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1041809002761 chaperone protein DnaJ; Provisional; Region: PRK14297 1041809002762 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1041809002763 HSP70 interaction site [polypeptide binding]; other site 1041809002764 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1041809002765 substrate binding site [polypeptide binding]; other site 1041809002766 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1041809002767 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1041809002768 dimer interface [polypeptide binding]; other site 1041809002769 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1041809002770 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1041809002771 nucleotide binding site [chemical binding]; other site 1041809002772 NEF interaction site [polypeptide binding]; other site 1041809002773 SBD interface [polypeptide binding]; other site 1041809002774 GrpE; Region: GrpE; pfam01025 1041809002775 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1041809002776 dimer interface [polypeptide binding]; other site 1041809002777 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1041809002778 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1041809002779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1041809002780 DNA-binding site [nucleotide binding]; DNA binding site 1041809002781 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 1041809002782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041809002783 FeS/SAM binding site; other site 1041809002784 HemN C-terminal domain; Region: HemN_C; pfam06969 1041809002785 GTP-binding protein LepA; Provisional; Region: PRK05433 1041809002786 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1041809002787 G1 box; other site 1041809002788 putative GEF interaction site [polypeptide binding]; other site 1041809002789 GTP/Mg2+ binding site [chemical binding]; other site 1041809002790 Switch I region; other site 1041809002791 G2 box; other site 1041809002792 G3 box; other site 1041809002793 Switch II region; other site 1041809002794 G4 box; other site 1041809002795 G5 box; other site 1041809002796 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1041809002797 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1041809002798 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1041809002799 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1041809002800 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1041809002801 germination protease; Provisional; Region: PRK12362 1041809002802 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1041809002803 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1041809002804 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1041809002805 Competence protein; Region: Competence; pfam03772 1041809002806 SpoVA protein; Region: SpoVA; cl04298 1041809002807 stage V sporulation protein AD; Validated; Region: PRK08304 1041809002808 stage V sporulation protein AD; Provisional; Region: PRK12404 1041809002809 SpoVA protein; Region: SpoVA; cl04298 1041809002810 Flagellar protein (FlbD); Region: FlbD; pfam06289 1041809002811 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1041809002812 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1041809002813 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 1041809002814 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1041809002815 Walker A motif/ATP binding site; other site 1041809002816 Walker B motif; other site 1041809002817 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 1041809002818 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1041809002819 FliG C-terminal domain; Region: FliG_C; pfam01706 1041809002820 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630 1041809002821 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1041809002822 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1041809002823 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1041809002824 flagellin; Provisional; Region: PRK12807 1041809002825 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1041809002826 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1041809002827 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1041809002828 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1041809002829 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1041809002830 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1041809002831 methionine cluster; other site 1041809002832 active site 1041809002833 phosphorylation site [posttranslational modification] 1041809002834 metal binding site [ion binding]; metal-binding site 1041809002835 Asp23 family; Region: Asp23; pfam03780 1041809002836 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1041809002837 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1041809002838 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1041809002839 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 1041809002840 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1041809002841 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1041809002842 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 1041809002843 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1041809002844 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1041809002845 Walker A motif; other site 1041809002846 ATP binding site [chemical binding]; other site 1041809002847 elongation factor P; Validated; Region: PRK00529 1041809002848 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1041809002849 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1041809002850 RNA binding site [nucleotide binding]; other site 1041809002851 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1041809002852 RNA binding site [nucleotide binding]; other site 1041809002853 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1041809002854 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1041809002855 Type II/IV secretion system protein; Region: T2SE; pfam00437 1041809002856 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1041809002857 Walker A motif; other site 1041809002858 ATP binding site [chemical binding]; other site 1041809002859 Walker B motif; other site 1041809002860 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1041809002861 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1041809002862 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1041809002863 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1041809002864 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1041809002865 Walker A/P-loop; other site 1041809002866 ATP binding site [chemical binding]; other site 1041809002867 Q-loop/lid; other site 1041809002868 ABC transporter signature motif; other site 1041809002869 Walker B; other site 1041809002870 D-loop; other site 1041809002871 H-loop/switch region; other site 1041809002872 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1041809002873 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1041809002874 ABC-ATPase subunit interface; other site 1041809002875 dimer interface [polypeptide binding]; other site 1041809002876 putative PBP binding regions; other site 1041809002877 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 1041809002878 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1041809002879 intersubunit interface [polypeptide binding]; other site 1041809002880 peroxiredoxin; Region: AhpC; TIGR03137 1041809002881 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1041809002882 dimer interface [polypeptide binding]; other site 1041809002883 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1041809002884 catalytic triad [active] 1041809002885 peroxidatic and resolving cysteines [active] 1041809002886 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 1041809002887 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1041809002888 beta-galactosidase; Region: BGL; TIGR03356 1041809002889 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1041809002890 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1041809002891 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1041809002892 active site 1041809002893 P-loop; other site 1041809002894 phosphorylation site [posttranslational modification] 1041809002895 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1041809002896 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1041809002897 NAD binding site [chemical binding]; other site 1041809002898 sugar binding site [chemical binding]; other site 1041809002899 divalent metal binding site [ion binding]; other site 1041809002900 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1041809002901 dimer interface [polypeptide binding]; other site 1041809002902 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1041809002903 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1041809002904 AP (apurinic/apyrimidinic) site pocket; other site 1041809002905 DNA interaction; other site 1041809002906 Metal-binding active site; metal-binding site 1041809002907 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1041809002908 active site 1041809002909 intersubunit interface [polypeptide binding]; other site 1041809002910 Zn2+ binding site [ion binding]; other site 1041809002911 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1041809002912 active site 1041809002913 P-loop; other site 1041809002914 phosphorylation site [posttranslational modification] 1041809002915 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1041809002916 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1041809002917 active site 1041809002918 phosphorylation site [posttranslational modification] 1041809002919 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1041809002920 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1041809002921 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1041809002922 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1041809002923 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1041809002924 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1041809002925 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1041809002926 heme-binding site [chemical binding]; other site 1041809002927 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1041809002928 heme-binding site [chemical binding]; other site 1041809002929 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1041809002930 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1041809002931 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1041809002932 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1041809002933 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1041809002934 active site 1041809002935 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1041809002936 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1041809002937 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1041809002938 sporulation sigma factor SigF; Validated; Region: PRK05572 1041809002939 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1041809002940 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1041809002941 DNA binding residues [nucleotide binding] 1041809002942 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1041809002943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041809002944 ATP binding site [chemical binding]; other site 1041809002945 Mg2+ binding site [ion binding]; other site 1041809002946 G-X-G motif; other site 1041809002947 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1041809002948 anti sigma factor interaction site; other site 1041809002949 regulatory phosphorylation site [posttranslational modification]; other site 1041809002950 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1041809002951 Peptidase family M28; Region: Peptidase_M28; pfam04389 1041809002952 metal binding site [ion binding]; metal-binding site 1041809002953 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1041809002954 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1041809002955 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809002956 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1041809002957 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809002958 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809002959 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809002960 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1041809002961 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1041809002962 putative active site [active] 1041809002963 putative metal binding site [ion binding]; other site 1041809002964 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1041809002965 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1041809002966 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1041809002967 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1041809002968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041809002969 homodimer interface [polypeptide binding]; other site 1041809002970 catalytic residue [active] 1041809002971 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1041809002972 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1041809002973 dimer interface [polypeptide binding]; other site 1041809002974 putative CheW interface [polypeptide binding]; other site 1041809002975 DNA repair protein RadA; Provisional; Region: PRK11823 1041809002976 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1041809002977 Walker A motif; other site 1041809002978 ATP binding site [chemical binding]; other site 1041809002979 Walker B motif; other site 1041809002980 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1041809002981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1041809002982 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 1041809002983 active site 1041809002984 catalytic triad [active] 1041809002985 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 1041809002986 active site 1041809002987 catalytic triad [active] 1041809002988 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1041809002989 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1041809002990 glutaminase active site [active] 1041809002991 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1041809002992 dimer interface [polypeptide binding]; other site 1041809002993 active site 1041809002994 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1041809002995 dimer interface [polypeptide binding]; other site 1041809002996 active site 1041809002997 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809002998 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809002999 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809003000 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809003001 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1041809003002 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1041809003003 putative ligand binding site [chemical binding]; other site 1041809003004 putative NAD binding site [chemical binding]; other site 1041809003005 catalytic site [active] 1041809003006 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1041809003007 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1041809003008 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1041809003009 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1041809003010 putative active site [active] 1041809003011 aminotransferase A; Validated; Region: PRK07683 1041809003012 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1041809003013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041809003014 homodimer interface [polypeptide binding]; other site 1041809003015 catalytic residue [active] 1041809003016 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 1041809003017 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1041809003018 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1041809003019 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1041809003020 trimer interface [polypeptide binding]; other site 1041809003021 active site 1041809003022 substrate binding site [chemical binding]; other site 1041809003023 CoA binding site [chemical binding]; other site 1041809003024 single-stranded DNA-binding protein; Provisional; Region: PRK05813 1041809003025 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1041809003026 dimer interface [polypeptide binding]; other site 1041809003027 ssDNA binding site [nucleotide binding]; other site 1041809003028 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1041809003029 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1041809003030 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 1041809003031 Predicted transcriptional regulator [Transcription]; Region: COG3432 1041809003032 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1041809003033 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1041809003034 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1041809003035 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041809003036 active site 1041809003037 HIGH motif; other site 1041809003038 nucleotide binding site [chemical binding]; other site 1041809003039 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1041809003040 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1041809003041 active site 1041809003042 KMSKS motif; other site 1041809003043 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1041809003044 tRNA binding surface [nucleotide binding]; other site 1041809003045 anticodon binding site; other site 1041809003046 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1041809003047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041809003048 TPR motif; other site 1041809003049 TPR repeat; Region: TPR_11; pfam13414 1041809003050 binding surface 1041809003051 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1041809003052 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1041809003053 RecX family; Region: RecX; cl00936 1041809003054 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1041809003055 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1041809003056 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1041809003057 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809003058 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 1041809003059 Rubredoxin; Region: Rubredoxin; pfam00301 1041809003060 iron binding site [ion binding]; other site 1041809003061 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 1041809003062 Rubrerythrin [Energy production and conversion]; Region: COG1592 1041809003063 diiron binding motif [ion binding]; other site 1041809003064 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1041809003065 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1041809003066 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1041809003067 nucleotide binding pocket [chemical binding]; other site 1041809003068 K-X-D-G motif; other site 1041809003069 catalytic site [active] 1041809003070 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1041809003071 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1041809003072 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1041809003073 Dimer interface [polypeptide binding]; other site 1041809003074 BRCT sequence motif; other site 1041809003075 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1041809003076 Part of AAA domain; Region: AAA_19; pfam13245 1041809003077 Family description; Region: UvrD_C_2; pfam13538 1041809003078 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1041809003079 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1041809003080 RNA binding surface [nucleotide binding]; other site 1041809003081 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1041809003082 active site 1041809003083 uracil binding [chemical binding]; other site 1041809003084 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1041809003085 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1041809003086 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1041809003087 catalytic residue [active] 1041809003088 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 1041809003089 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1041809003090 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1041809003091 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1041809003092 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1041809003093 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1041809003094 active site 1041809003095 dimer interface [polypeptide binding]; other site 1041809003096 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1041809003097 dimer interface [polypeptide binding]; other site 1041809003098 active site 1041809003099 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1041809003100 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1041809003101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041809003102 Walker A/P-loop; other site 1041809003103 ATP binding site [chemical binding]; other site 1041809003104 Q-loop/lid; other site 1041809003105 ABC transporter signature motif; other site 1041809003106 Walker B; other site 1041809003107 D-loop; other site 1041809003108 H-loop/switch region; other site 1041809003109 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1041809003110 DJ-1 family protein; Region: not_thiJ; TIGR01383 1041809003111 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1041809003112 conserved cys residue [active] 1041809003113 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1041809003114 trimer interface [polypeptide binding]; other site 1041809003115 active site 1041809003116 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1041809003117 amidase catalytic site [active] 1041809003118 Zn binding residues [ion binding]; other site 1041809003119 substrate binding site [chemical binding]; other site 1041809003120 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1041809003121 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1041809003122 FtsX-like permease family; Region: FtsX; pfam02687 1041809003123 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1041809003124 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1041809003125 Walker A/P-loop; other site 1041809003126 ATP binding site [chemical binding]; other site 1041809003127 Q-loop/lid; other site 1041809003128 ABC transporter signature motif; other site 1041809003129 Walker B; other site 1041809003130 D-loop; other site 1041809003131 H-loop/switch region; other site 1041809003132 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041809003133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041809003134 ATP binding site [chemical binding]; other site 1041809003135 Mg2+ binding site [ion binding]; other site 1041809003136 G-X-G motif; other site 1041809003137 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1041809003138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041809003139 active site 1041809003140 phosphorylation site [posttranslational modification] 1041809003141 intermolecular recognition site; other site 1041809003142 dimerization interface [polypeptide binding]; other site 1041809003143 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1041809003144 DNA binding site [nucleotide binding] 1041809003145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1041809003146 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 1041809003147 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1041809003148 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1041809003149 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 1041809003150 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1041809003151 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1041809003152 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1041809003153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1041809003154 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1041809003155 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1041809003156 DNA binding residues [nucleotide binding] 1041809003157 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 1041809003158 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1041809003159 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1041809003160 FHIPEP family; Region: FHIPEP; pfam00771 1041809003161 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 1041809003162 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1041809003163 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1041809003164 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1041809003165 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1041809003166 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1041809003167 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1041809003168 flagellar motor protein MotS; Reviewed; Region: PRK06925 1041809003169 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1041809003170 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1041809003171 ligand binding site [chemical binding]; other site 1041809003172 flagellar motor protein MotP; Reviewed; Region: PRK06926 1041809003173 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1041809003174 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1041809003175 active site 1041809003176 adenylosuccinate lyase; Provisional; Region: PRK07492 1041809003177 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1041809003178 tetramer interface [polypeptide binding]; other site 1041809003179 active site 1041809003180 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1041809003181 putative oxidoreductase; Provisional; Region: PRK11579 1041809003182 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1041809003183 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1041809003184 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1041809003185 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1041809003186 GDP-binding site [chemical binding]; other site 1041809003187 ACT binding site; other site 1041809003188 IMP binding site; other site 1041809003189 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1041809003190 ScpA/B protein; Region: ScpA_ScpB; cl00598 1041809003191 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1041809003192 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1041809003193 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1041809003194 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1041809003195 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1041809003196 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1041809003197 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 1041809003198 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1041809003199 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1041809003200 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1041809003201 phosphopentomutase; Provisional; Region: PRK05362 1041809003202 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1041809003203 Integral membrane protein DUF95; Region: DUF95; cl00572 1041809003204 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1041809003205 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1041809003206 dimer interface [polypeptide binding]; other site 1041809003207 ADP-ribose binding site [chemical binding]; other site 1041809003208 active site 1041809003209 nudix motif; other site 1041809003210 metal binding site [ion binding]; metal-binding site 1041809003211 potential frameshift: common BLAST hit: gi|347542822|ref|YP_004857459.1| putative lipoprotein 1041809003212 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1041809003213 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1041809003214 Walker A/P-loop; other site 1041809003215 ATP binding site [chemical binding]; other site 1041809003216 Q-loop/lid; other site 1041809003217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041809003218 ABC transporter signature motif; other site 1041809003219 Walker B; other site 1041809003220 D-loop; other site 1041809003221 H-loop/switch region; other site 1041809003222 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1041809003223 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1041809003224 active site 1041809003225 metal binding site [ion binding]; metal-binding site 1041809003226 DNA binding site [nucleotide binding] 1041809003227 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1041809003228 competence damage-inducible protein A; Provisional; Region: PRK00549 1041809003229 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1041809003230 putative MPT binding site; other site 1041809003231 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1041809003232 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041809003233 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1041809003234 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041809003235 dimer interface [polypeptide binding]; other site 1041809003236 phosphorylation site [posttranslational modification] 1041809003237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041809003238 ATP binding site [chemical binding]; other site 1041809003239 Mg2+ binding site [ion binding]; other site 1041809003240 G-X-G motif; other site 1041809003241 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1041809003242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041809003243 active site 1041809003244 phosphorylation site [posttranslational modification] 1041809003245 intermolecular recognition site; other site 1041809003246 dimerization interface [polypeptide binding]; other site 1041809003247 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1041809003248 DNA binding site [nucleotide binding] 1041809003249 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1041809003250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 1041809003251 Putative glucoamylase; Region: Glycoamylase; pfam10091 1041809003252 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1041809003253 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1041809003254 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1041809003255 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1041809003256 Walker A/P-loop; other site 1041809003257 ATP binding site [chemical binding]; other site 1041809003258 Q-loop/lid; other site 1041809003259 ABC transporter signature motif; other site 1041809003260 Walker B; other site 1041809003261 D-loop; other site 1041809003262 H-loop/switch region; other site 1041809003263 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1041809003264 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1041809003265 putative ligand binding residues [chemical binding]; other site 1041809003266 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1041809003267 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1041809003268 Walker A/P-loop; other site 1041809003269 ATP binding site [chemical binding]; other site 1041809003270 Q-loop/lid; other site 1041809003271 ABC transporter signature motif; other site 1041809003272 Walker B; other site 1041809003273 D-loop; other site 1041809003274 H-loop/switch region; other site 1041809003275 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1041809003276 ABC-ATPase subunit interface; other site 1041809003277 dimer interface [polypeptide binding]; other site 1041809003278 putative PBP binding regions; other site 1041809003279 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1041809003280 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1041809003281 ABC-ATPase subunit interface; other site 1041809003282 dimer interface [polypeptide binding]; other site 1041809003283 putative PBP binding regions; other site 1041809003284 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1041809003285 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1041809003286 intersubunit interface [polypeptide binding]; other site 1041809003287 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1041809003288 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1041809003289 ABC-ATPase subunit interface; other site 1041809003290 dimer interface [polypeptide binding]; other site 1041809003291 putative PBP binding regions; other site 1041809003292 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1041809003293 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1041809003294 ABC-ATPase subunit interface; other site 1041809003295 dimer interface [polypeptide binding]; other site 1041809003296 putative PBP binding regions; other site 1041809003297 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1041809003298 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1041809003299 Walker A/P-loop; other site 1041809003300 ATP binding site [chemical binding]; other site 1041809003301 Q-loop/lid; other site 1041809003302 ABC transporter signature motif; other site 1041809003303 Walker B; other site 1041809003304 D-loop; other site 1041809003305 H-loop/switch region; other site 1041809003306 H+ Antiporter protein; Region: 2A0121; TIGR00900 1041809003307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041809003308 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1041809003309 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 1041809003310 Protein of unknown function DUF262; Region: DUF262; pfam03235 1041809003311 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1041809003312 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1041809003313 Cupin domain; Region: Cupin_2; cl17218 1041809003314 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1041809003315 active site 1041809003316 conformational flexibility of ligand binding pocket; other site 1041809003317 ADP-ribosylating toxin turn-turn motif; other site 1041809003318 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1041809003319 dimanganese center [ion binding]; other site 1041809003320 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1041809003321 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 1041809003322 Rubredoxin [Energy production and conversion]; Region: COG1773 1041809003323 iron binding site [ion binding]; other site 1041809003324 Rubrerythrin [Energy production and conversion]; Region: COG1592 1041809003325 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1041809003326 binuclear metal center [ion binding]; other site 1041809003327 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 1041809003328 iron binding site [ion binding]; other site 1041809003329 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1041809003330 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1041809003331 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1041809003332 MarR family; Region: MarR_2; pfam12802 1041809003333 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1041809003334 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1041809003335 tetramer interface [polypeptide binding]; other site 1041809003336 heme binding pocket [chemical binding]; other site 1041809003337 NADPH binding site [chemical binding]; other site 1041809003338 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1041809003339 metal binding site 2 [ion binding]; metal-binding site 1041809003340 putative DNA binding helix; other site 1041809003341 metal binding site 1 [ion binding]; metal-binding site 1041809003342 dimer interface [polypeptide binding]; other site 1041809003343 structural Zn2+ binding site [ion binding]; other site 1041809003344 BioY family; Region: BioY; pfam02632 1041809003345 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 1041809003346 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1041809003347 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1041809003348 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1041809003349 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1041809003350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041809003351 S-adenosylmethionine binding site [chemical binding]; other site 1041809003352 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1041809003353 active site 1041809003354 NAD binding site [chemical binding]; other site 1041809003355 pyrophosphatase PpaX; Provisional; Region: PRK13288 1041809003356 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1041809003357 active site 1041809003358 motif I; other site 1041809003359 motif II; other site 1041809003360 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1041809003361 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1041809003362 dimer interface [polypeptide binding]; other site 1041809003363 putative CheW interface [polypeptide binding]; other site 1041809003364 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1041809003365 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1041809003366 dimer interface [polypeptide binding]; other site 1041809003367 putative CheW interface [polypeptide binding]; other site 1041809003368 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 1041809003369 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 1041809003370 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1041809003371 carboxyltransferase (CT) interaction site; other site 1041809003372 biotinylation site [posttranslational modification]; other site 1041809003373 oxaloacetate decarboxylase; Provisional; Region: PRK12331 1041809003374 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1041809003375 active site 1041809003376 catalytic residues [active] 1041809003377 metal binding site [ion binding]; metal-binding site 1041809003378 homodimer binding site [polypeptide binding]; other site 1041809003379 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1041809003380 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1041809003381 trimerization site [polypeptide binding]; other site 1041809003382 active site 1041809003383 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1041809003384 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1041809003385 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1041809003386 catalytic residue [active] 1041809003387 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1041809003388 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1041809003389 FeS assembly protein SufB; Region: sufB; TIGR01980 1041809003390 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1041809003391 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1041809003392 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1041809003393 Walker A/P-loop; other site 1041809003394 ATP binding site [chemical binding]; other site 1041809003395 Q-loop/lid; other site 1041809003396 ABC transporter signature motif; other site 1041809003397 Walker B; other site 1041809003398 D-loop; other site 1041809003399 H-loop/switch region; other site 1041809003400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1041809003401 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1041809003402 active site 1041809003403 motif I; other site 1041809003404 motif II; other site 1041809003405 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1041809003406 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1041809003407 active site 1041809003408 dimer interface [polypeptide binding]; other site 1041809003409 metal binding site [ion binding]; metal-binding site 1041809003410 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1041809003411 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1041809003412 Tetramer interface [polypeptide binding]; other site 1041809003413 active site 1041809003414 FMN-binding site [chemical binding]; other site 1041809003415 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1041809003416 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1041809003417 active site 1041809003418 hinge; other site 1041809003419 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1041809003420 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1041809003421 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1041809003422 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1041809003423 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1041809003424 active site 1041809003425 dimer interface [polypeptide binding]; other site 1041809003426 effector binding site; other site 1041809003427 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1041809003428 TSCPD domain; Region: TSCPD; cl14834 1041809003429 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 1041809003430 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1041809003431 AsnC family; Region: AsnC_trans_reg; pfam01037 1041809003432 Domain of unknown function (DUF378); Region: DUF378; cl00943 1041809003433 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1041809003434 active site 1041809003435 metal-binding site [ion binding] 1041809003436 nucleotide-binding site [chemical binding]; other site 1041809003437 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1041809003438 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1041809003439 putative acyl-acceptor binding pocket; other site 1041809003440 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1041809003441 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1041809003442 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1041809003443 active site 1041809003444 HIGH motif; other site 1041809003445 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1041809003446 active site 1041809003447 KMSKS motif; other site 1041809003448 RNase_H superfamily; Region: RNase_H_2; pfam13482 1041809003449 FeoA domain; Region: FeoA; cl00838 1041809003450 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1041809003451 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1041809003452 G1 box; other site 1041809003453 GTP/Mg2+ binding site [chemical binding]; other site 1041809003454 Switch I region; other site 1041809003455 G2 box; other site 1041809003456 G3 box; other site 1041809003457 Switch II region; other site 1041809003458 G4 box; other site 1041809003459 G5 box; other site 1041809003460 Nucleoside recognition; Region: Gate; pfam07670 1041809003461 Nucleoside recognition; Region: Gate; pfam07670 1041809003462 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1041809003463 Putative carbohydrate binding domain; Region: CBM_X; pfam06204 1041809003464 Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_4; cd11751 1041809003465 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1041809003466 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1041809003467 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1041809003468 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1041809003469 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1041809003470 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1041809003471 active site 1041809003472 HIGH motif; other site 1041809003473 KMSK motif region; other site 1041809003474 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1041809003475 tRNA binding surface [nucleotide binding]; other site 1041809003476 anticodon binding site; other site 1041809003477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041809003478 S-adenosylmethionine binding site [chemical binding]; other site 1041809003479 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1041809003480 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1041809003481 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1041809003482 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1041809003483 Arginase family; Region: Arginase; cd09989 1041809003484 active site 1041809003485 Mn binding site [ion binding]; other site 1041809003486 oligomer interface [polypeptide binding]; other site 1041809003487 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1041809003488 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1041809003489 active site 1041809003490 catalytic site [active] 1041809003491 substrate binding site [chemical binding]; other site 1041809003492 glutamate dehydrogenase; Provisional; Region: PRK09414 1041809003493 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1041809003494 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1041809003495 NAD(P) binding pocket [chemical binding]; other site 1041809003496 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 1041809003497 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1041809003498 phosphofructokinase; Region: PFK_mixed; TIGR02483 1041809003499 active site 1041809003500 ADP/pyrophosphate binding site [chemical binding]; other site 1041809003501 dimerization interface [polypeptide binding]; other site 1041809003502 allosteric effector site; other site 1041809003503 fructose-1,6-bisphosphate binding site; other site 1041809003504 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1041809003505 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1041809003506 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1041809003507 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1041809003508 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1041809003509 catalytic triad [active] 1041809003510 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1041809003511 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1041809003512 active site 1041809003513 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1041809003514 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1041809003515 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1041809003516 NAD binding site [chemical binding]; other site 1041809003517 substrate binding site [chemical binding]; other site 1041809003518 homodimer interface [polypeptide binding]; other site 1041809003519 active site 1041809003520 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1041809003521 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1041809003522 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1041809003523 active site 1041809003524 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1041809003525 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1041809003526 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1041809003527 Na binding site [ion binding]; other site 1041809003528 putative substrate binding site [chemical binding]; other site 1041809003529 potential protein location (hypothetical protein) that overlaps protein (cytosine permease) 1041809003530 cytosine deaminase; Provisional; Region: PRK09230 1041809003531 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1041809003532 active site 1041809003533 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1041809003534 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1041809003535 putative metal binding site; other site 1041809003536 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1041809003537 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1041809003538 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1041809003539 AAA domain; Region: AAA_27; pfam13514 1041809003540 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1041809003541 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1041809003542 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1041809003543 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1041809003544 NodB motif; other site 1041809003545 active site 1041809003546 catalytic site [active] 1041809003547 Zn binding site [ion binding]; other site 1041809003548 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1041809003549 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1041809003550 Glycoprotease family; Region: Peptidase_M22; pfam00814 1041809003551 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1041809003552 Predicted membrane protein [Function unknown]; Region: COG3601 1041809003553 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1041809003554 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1041809003555 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1041809003556 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 1041809003557 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1041809003558 RNA binding site [nucleotide binding]; other site 1041809003559 peptide chain release factor 2; Provisional; Region: PRK05589 1041809003560 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1041809003561 RF-1 domain; Region: RF-1; pfam00472 1041809003562 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1041809003563 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1041809003564 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1041809003565 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041809003566 nucleotide binding region [chemical binding]; other site 1041809003567 ATP-binding site [chemical binding]; other site 1041809003568 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1041809003569 30S subunit binding site; other site 1041809003570 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1041809003571 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041809003572 active site 1041809003573 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1041809003574 AAA domain; Region: AAA_30; pfam13604 1041809003575 Family description; Region: UvrD_C_2; pfam13538 1041809003576 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1041809003577 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1041809003578 active site 1041809003579 dimer interface [polypeptide binding]; other site 1041809003580 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1041809003581 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1041809003582 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1041809003583 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1041809003584 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1041809003585 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1041809003586 Peptidase family M23; Region: Peptidase_M23; pfam01551 1041809003587 Stage II sporulation protein; Region: SpoIID; pfam08486 1041809003588 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1041809003589 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1041809003590 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1041809003591 hinge; other site 1041809003592 active site 1041809003593 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1041809003594 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1041809003595 active site 1041809003596 homodimer interface [polypeptide binding]; other site 1041809003597 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1041809003598 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1041809003599 Mg++ binding site [ion binding]; other site 1041809003600 putative catalytic motif [active] 1041809003601 substrate binding site [chemical binding]; other site 1041809003602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041809003603 active site 1041809003604 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1041809003605 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1041809003606 active site 1041809003607 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1041809003608 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1041809003609 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1041809003610 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1041809003611 RF-1 domain; Region: RF-1; pfam00472 1041809003612 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 1041809003613 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1041809003614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041809003615 S-adenosylmethionine binding site [chemical binding]; other site 1041809003616 thymidine kinase; Provisional; Region: PRK04296 1041809003617 AAA domain; Region: AAA_14; pfam13173 1041809003618 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1041809003619 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1041809003620 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1041809003621 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1041809003622 RNA binding site [nucleotide binding]; other site 1041809003623 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1041809003624 Walker A motif; other site 1041809003625 ATP binding site [chemical binding]; other site 1041809003626 Walker B motif; other site 1041809003627 CTP synthetase; Validated; Region: pyrG; PRK05380 1041809003628 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1041809003629 Catalytic site [active] 1041809003630 active site 1041809003631 UTP binding site [chemical binding]; other site 1041809003632 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1041809003633 active site 1041809003634 putative oxyanion hole; other site 1041809003635 catalytic triad [active] 1041809003636 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1041809003637 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1041809003638 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 1041809003639 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1041809003640 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1041809003641 Spore germination protein; Region: Spore_permease; cl17796 1041809003642 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1041809003643 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1041809003644 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1041809003645 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1041809003646 cyanophycin synthetase; Provisional; Region: PRK14016 1041809003647 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1041809003648 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1041809003649 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1041809003650 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1041809003651 proposed catalytic triad [active] 1041809003652 active site nucleophile [active] 1041809003653 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 1041809003654 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 1041809003655 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 1041809003656 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041809003657 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1041809003658 YabG peptidase U57; Region: Peptidase_U57; cl05250 1041809003659 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1041809003660 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1041809003661 NAD binding site [chemical binding]; other site 1041809003662 homotetramer interface [polypeptide binding]; other site 1041809003663 homodimer interface [polypeptide binding]; other site 1041809003664 substrate binding site [chemical binding]; other site 1041809003665 active site 1041809003666 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1041809003667 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1041809003668 substrate binding site [chemical binding]; other site 1041809003669 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1041809003670 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041809003671 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1041809003672 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1041809003673 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1041809003674 EDD domain protein, DegV family; Region: DegV; TIGR00762 1041809003675 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1041809003676 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1041809003677 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1041809003678 VanW like protein; Region: VanW; pfam04294 1041809003679 G5 domain; Region: G5; pfam07501 1041809003680 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1041809003681 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1041809003682 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1041809003683 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1041809003684 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1041809003685 minor groove reading motif; other site 1041809003686 helix-hairpin-helix signature motif; other site 1041809003687 substrate binding pocket [chemical binding]; other site 1041809003688 active site 1041809003689 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1041809003690 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1041809003691 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1041809003692 putative acyl-acceptor binding pocket; other site 1041809003693 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1041809003694 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1041809003695 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1041809003696 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1041809003697 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1041809003698 Predicted membrane protein [Function unknown]; Region: COG2323 1041809003699 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 1041809003700 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1041809003701 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1041809003702 intersubunit interface [polypeptide binding]; other site 1041809003703 active site 1041809003704 zinc binding site [ion binding]; other site 1041809003705 Na+ binding site [ion binding]; other site 1041809003706 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 1041809003707 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 1041809003708 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1041809003709 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1041809003710 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1041809003711 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1041809003712 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1041809003713 G1 box; other site 1041809003714 GTP/Mg2+ binding site [chemical binding]; other site 1041809003715 Switch I region; other site 1041809003716 G2 box; other site 1041809003717 G3 box; other site 1041809003718 Switch II region; other site 1041809003719 G4 box; other site 1041809003720 G5 box; other site 1041809003721 Nucleoside recognition; Region: Gate; pfam07670 1041809003722 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1041809003723 Nucleoside recognition; Region: Gate; pfam07670 1041809003724 FeoA domain; Region: FeoA; pfam04023 1041809003725 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1041809003726 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1041809003727 metal binding site [ion binding]; metal-binding site 1041809003728 oligoendopeptidase F; Region: pepF; TIGR00181 1041809003729 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1041809003730 active site 1041809003731 Zn binding site [ion binding]; other site 1041809003732 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1041809003733 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1041809003734 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1041809003735 Zn binding site [ion binding]; other site 1041809003736 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 1041809003737 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1041809003738 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1041809003739 DNA binding site [nucleotide binding] 1041809003740 domain linker motif; other site 1041809003741 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1041809003742 dimerization interface [polypeptide binding]; other site 1041809003743 ligand binding site [chemical binding]; other site 1041809003744 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1041809003745 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1041809003746 HIGH motif; other site 1041809003747 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1041809003748 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041809003749 active site 1041809003750 KMSKS motif; other site 1041809003751 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1041809003752 tRNA binding surface [nucleotide binding]; other site 1041809003753 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1041809003754 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1041809003755 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1041809003756 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1041809003757 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041809003758 ATP binding site [chemical binding]; other site 1041809003759 putative Mg++ binding site [ion binding]; other site 1041809003760 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041809003761 nucleotide binding region [chemical binding]; other site 1041809003762 ATP-binding site [chemical binding]; other site 1041809003763 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1041809003764 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1041809003765 active site 1041809003766 HIGH motif; other site 1041809003767 dimer interface [polypeptide binding]; other site 1041809003768 KMSKS motif; other site 1041809003769 Probable zinc-binding domain; Region: zf-trcl; pfam13451 1041809003770 YfhG lipoprotein; Region: Lipoprotein_20; cl08141 1041809003771 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1041809003772 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1041809003773 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1041809003774 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1041809003775 metal binding site [ion binding]; metal-binding site 1041809003776 active site 1041809003777 I-site; other site 1041809003778 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 1041809003779 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1041809003780 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1041809003781 synthetase active site [active] 1041809003782 NTP binding site [chemical binding]; other site 1041809003783 metal binding site [ion binding]; metal-binding site 1041809003784 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1041809003785 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1041809003786 G1 box; other site 1041809003787 putative GEF interaction site [polypeptide binding]; other site 1041809003788 GTP/Mg2+ binding site [chemical binding]; other site 1041809003789 Switch I region; other site 1041809003790 G2 box; other site 1041809003791 G3 box; other site 1041809003792 Switch II region; other site 1041809003793 G4 box; other site 1041809003794 G5 box; other site 1041809003795 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1041809003796 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1041809003797 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1041809003798 NAD binding site [chemical binding]; other site 1041809003799 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1041809003800 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1041809003801 active site 1041809003802 HIGH motif; other site 1041809003803 dimer interface [polypeptide binding]; other site 1041809003804 KMSKS motif; other site 1041809003805 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1041809003806 RNA binding surface [nucleotide binding]; other site 1041809003807 Putative glucoamylase; Region: Glycoamylase; pfam10091 1041809003808 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 1041809003809 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1041809003810 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1041809003811 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1041809003812 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1041809003813 putative catalytic cysteine [active] 1041809003814 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1041809003815 putative active site [active] 1041809003816 metal binding site [ion binding]; metal-binding site 1041809003817 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1041809003818 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1041809003819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1041809003820 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1041809003821 active site 1041809003822 motif I; other site 1041809003823 motif II; other site 1041809003824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1041809003825 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1041809003826 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1041809003827 active site 1041809003828 substrate binding site [chemical binding]; other site 1041809003829 metal binding site [ion binding]; metal-binding site 1041809003830 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1041809003831 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 1041809003832 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 1041809003833 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1041809003834 TPP-binding site [chemical binding]; other site 1041809003835 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 1041809003836 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1041809003837 dimer interface [polypeptide binding]; other site 1041809003838 PYR/PP interface [polypeptide binding]; other site 1041809003839 TPP binding site [chemical binding]; other site 1041809003840 substrate binding site [chemical binding]; other site 1041809003841 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1041809003842 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1041809003843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1041809003844 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1041809003845 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1041809003846 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1041809003847 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1041809003848 catalytic residues [active] 1041809003849 isoaspartyl dipeptidase; Provisional; Region: PRK10657 1041809003850 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1041809003851 active site 1041809003852 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1041809003853 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1041809003854 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1041809003855 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1041809003856 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 1041809003857 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1041809003858 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1041809003859 active site 1041809003860 metal binding site [ion binding]; metal-binding site 1041809003861 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1041809003862 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1041809003863 23S rRNA interface [nucleotide binding]; other site 1041809003864 L3 interface [polypeptide binding]; other site 1041809003865 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1041809003866 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1041809003867 dimerization interface 3.5A [polypeptide binding]; other site 1041809003868 active site 1041809003869 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1041809003870 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 1041809003871 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1041809003872 Walker A/P-loop; other site 1041809003873 ATP binding site [chemical binding]; other site 1041809003874 Q-loop/lid; other site 1041809003875 ABC transporter signature motif; other site 1041809003876 Walker B; other site 1041809003877 D-loop; other site 1041809003878 H-loop/switch region; other site 1041809003879 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 1041809003880 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1041809003881 Walker A/P-loop; other site 1041809003882 ATP binding site [chemical binding]; other site 1041809003883 Q-loop/lid; other site 1041809003884 ABC transporter signature motif; other site 1041809003885 Walker B; other site 1041809003886 D-loop; other site 1041809003887 H-loop/switch region; other site 1041809003888 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1041809003889 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1041809003890 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1041809003891 alphaNTD homodimer interface [polypeptide binding]; other site 1041809003892 alphaNTD - beta interaction site [polypeptide binding]; other site 1041809003893 alphaNTD - beta' interaction site [polypeptide binding]; other site 1041809003894 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1041809003895 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1041809003896 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1041809003897 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1041809003898 RNA binding surface [nucleotide binding]; other site 1041809003899 30S ribosomal protein S11; Validated; Region: PRK05309 1041809003900 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1041809003901 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1041809003902 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1041809003903 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1041809003904 rRNA binding site [nucleotide binding]; other site 1041809003905 predicted 30S ribosome binding site; other site 1041809003906 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1041809003907 active site 1041809003908 adenylate kinase; Reviewed; Region: adk; PRK00279 1041809003909 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1041809003910 AMP-binding site [chemical binding]; other site 1041809003911 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1041809003912 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1041809003913 SecY translocase; Region: SecY; pfam00344 1041809003914 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1041809003915 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1041809003916 23S rRNA binding site [nucleotide binding]; other site 1041809003917 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1041809003918 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1041809003919 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1041809003920 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1041809003921 5S rRNA interface [nucleotide binding]; other site 1041809003922 23S rRNA interface [nucleotide binding]; other site 1041809003923 L5 interface [polypeptide binding]; other site 1041809003924 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1041809003925 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1041809003926 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1041809003927 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1041809003928 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1041809003929 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1041809003930 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1041809003931 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1041809003932 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1041809003933 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1041809003934 RNA binding site [nucleotide binding]; other site 1041809003935 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1041809003936 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1041809003937 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1041809003938 putative translocon interaction site; other site 1041809003939 23S rRNA interface [nucleotide binding]; other site 1041809003940 signal recognition particle (SRP54) interaction site; other site 1041809003941 L23 interface [polypeptide binding]; other site 1041809003942 trigger factor interaction site; other site 1041809003943 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1041809003944 23S rRNA interface [nucleotide binding]; other site 1041809003945 5S rRNA interface [nucleotide binding]; other site 1041809003946 putative antibiotic binding site [chemical binding]; other site 1041809003947 L25 interface [polypeptide binding]; other site 1041809003948 L27 interface [polypeptide binding]; other site 1041809003949 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1041809003950 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1041809003951 G-X-X-G motif; other site 1041809003952 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1041809003953 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1041809003954 putative translocon binding site; other site 1041809003955 protein-rRNA interface [nucleotide binding]; other site 1041809003956 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1041809003957 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1041809003958 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1041809003959 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1041809003960 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1041809003961 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1041809003962 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1041809003963 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1041809003964 elongation factor Tu; Reviewed; Region: PRK00049 1041809003965 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1041809003966 G1 box; other site 1041809003967 GEF interaction site [polypeptide binding]; other site 1041809003968 GTP/Mg2+ binding site [chemical binding]; other site 1041809003969 Switch I region; other site 1041809003970 G2 box; other site 1041809003971 G3 box; other site 1041809003972 Switch II region; other site 1041809003973 G4 box; other site 1041809003974 G5 box; other site 1041809003975 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1041809003976 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1041809003977 Antibiotic Binding Site [chemical binding]; other site 1041809003978 elongation factor G; Reviewed; Region: PRK00007 1041809003979 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1041809003980 G1 box; other site 1041809003981 putative GEF interaction site [polypeptide binding]; other site 1041809003982 GTP/Mg2+ binding site [chemical binding]; other site 1041809003983 Switch I region; other site 1041809003984 G2 box; other site 1041809003985 G3 box; other site 1041809003986 Switch II region; other site 1041809003987 G4 box; other site 1041809003988 G5 box; other site 1041809003989 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1041809003990 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1041809003991 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1041809003992 30S ribosomal protein S7; Validated; Region: PRK05302 1041809003993 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1041809003994 S17 interaction site [polypeptide binding]; other site 1041809003995 S8 interaction site; other site 1041809003996 16S rRNA interaction site [nucleotide binding]; other site 1041809003997 streptomycin interaction site [chemical binding]; other site 1041809003998 23S rRNA interaction site [nucleotide binding]; other site 1041809003999 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1041809004000 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1041809004001 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1041809004002 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1041809004003 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1041809004004 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1041809004005 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1041809004006 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1041809004007 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1041809004008 G-loop; other site 1041809004009 DNA binding site [nucleotide binding] 1041809004010 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1041809004011 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1041809004012 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1041809004013 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1041809004014 RPB1 interaction site [polypeptide binding]; other site 1041809004015 RPB10 interaction site [polypeptide binding]; other site 1041809004016 RPB11 interaction site [polypeptide binding]; other site 1041809004017 RPB3 interaction site [polypeptide binding]; other site 1041809004018 RPB12 interaction site [polypeptide binding]; other site 1041809004019 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1041809004020 core dimer interface [polypeptide binding]; other site 1041809004021 peripheral dimer interface [polypeptide binding]; other site 1041809004022 L10 interface [polypeptide binding]; other site 1041809004023 L11 interface [polypeptide binding]; other site 1041809004024 putative EF-Tu interaction site [polypeptide binding]; other site 1041809004025 putative EF-G interaction site [polypeptide binding]; other site 1041809004026 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1041809004027 23S rRNA interface [nucleotide binding]; other site 1041809004028 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1041809004029 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1041809004030 mRNA/rRNA interface [nucleotide binding]; other site 1041809004031 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1041809004032 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1041809004033 23S rRNA interface [nucleotide binding]; other site 1041809004034 L7/L12 interface [polypeptide binding]; other site 1041809004035 putative thiostrepton binding site; other site 1041809004036 L25 interface [polypeptide binding]; other site 1041809004037 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1041809004038 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1041809004039 putative homodimer interface [polypeptide binding]; other site 1041809004040 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1041809004041 heterodimer interface [polypeptide binding]; other site 1041809004042 homodimer interface [polypeptide binding]; other site 1041809004043 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1041809004044 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1041809004045 elongation factor Tu; Reviewed; Region: PRK00049 1041809004046 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1041809004047 G1 box; other site 1041809004048 GEF interaction site [polypeptide binding]; other site 1041809004049 GTP/Mg2+ binding site [chemical binding]; other site 1041809004050 Switch I region; other site 1041809004051 G2 box; other site 1041809004052 G3 box; other site 1041809004053 Switch II region; other site 1041809004054 G4 box; other site 1041809004055 G5 box; other site 1041809004056 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1041809004057 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1041809004058 Antibiotic Binding Site [chemical binding]; other site 1041809004059 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1041809004060 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1041809004061 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1041809004062 DNA binding residues [nucleotide binding] 1041809004063 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1041809004064 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1041809004065 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1041809004066 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1041809004067 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1041809004068 active site 1041809004069 metal binding site [ion binding]; metal-binding site 1041809004070 dimerization interface [polypeptide binding]; other site 1041809004071 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1041809004072 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1041809004073 active site 1041809004074 HIGH motif; other site 1041809004075 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1041809004076 KMSKS motif; other site 1041809004077 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1041809004078 tRNA binding surface [nucleotide binding]; other site 1041809004079 anticodon binding site; other site 1041809004080 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1041809004081 substrate binding site; other site 1041809004082 dimer interface; other site 1041809004083 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1041809004084 Clp amino terminal domain; Region: Clp_N; pfam02861 1041809004085 Clp amino terminal domain; Region: Clp_N; pfam02861 1041809004086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041809004087 Walker A motif; other site 1041809004088 ATP binding site [chemical binding]; other site 1041809004089 Walker B motif; other site 1041809004090 arginine finger; other site 1041809004091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041809004092 Walker A motif; other site 1041809004093 ATP binding site [chemical binding]; other site 1041809004094 Walker B motif; other site 1041809004095 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1041809004096 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1041809004097 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1041809004098 ADP binding site [chemical binding]; other site 1041809004099 phosphagen binding site; other site 1041809004100 substrate specificity loop; other site 1041809004101 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1041809004102 UvrB/uvrC motif; Region: UVR; pfam02151 1041809004103 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1041809004104 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1041809004105 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1041809004106 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1041809004107 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1041809004108 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1041809004109 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1041809004110 TMP-binding site; other site 1041809004111 ATP-binding site [chemical binding]; other site 1041809004112 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1041809004113 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1041809004114 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1041809004115 catalytic residue [active] 1041809004116 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1041809004117 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1041809004118 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1041809004119 Cl binding site [ion binding]; other site 1041809004120 oligomer interface [polypeptide binding]; other site 1041809004121 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1041809004122 dimer interface [polypeptide binding]; other site 1041809004123 catalytic triad [active] 1041809004124 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 1041809004125 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1041809004126 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1041809004127 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1041809004128 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1041809004129 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1041809004130 motif 1; other site 1041809004131 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1041809004132 active site 1041809004133 motif 2; other site 1041809004134 motif 3; other site 1041809004135 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1041809004136 anticodon binding site; other site 1041809004137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041809004138 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1041809004139 Walker A motif; other site 1041809004140 ATP binding site [chemical binding]; other site 1041809004141 Walker B motif; other site 1041809004142 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1041809004143 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1041809004144 dimer interface [polypeptide binding]; other site 1041809004145 putative anticodon binding site; other site 1041809004146 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1041809004147 motif 1; other site 1041809004148 active site 1041809004149 motif 2; other site 1041809004150 motif 3; other site 1041809004151 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1041809004152 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1041809004153 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1041809004154 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1041809004155 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1041809004156 FMN binding site [chemical binding]; other site 1041809004157 active site 1041809004158 catalytic residues [active] 1041809004159 substrate binding site [chemical binding]; other site 1041809004160 FtsH Extracellular; Region: FtsH_ext; pfam06480 1041809004161 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1041809004162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041809004163 Walker A motif; other site 1041809004164 ATP binding site [chemical binding]; other site 1041809004165 Walker B motif; other site 1041809004166 arginine finger; other site 1041809004167 Peptidase family M41; Region: Peptidase_M41; pfam01434 1041809004168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041809004169 active site 1041809004170 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1041809004171 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1041809004172 Ligand Binding Site [chemical binding]; other site 1041809004173 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1041809004174 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1041809004175 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1041809004176 hypothetical protein; Provisional; Region: PRK05807 1041809004177 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1041809004178 RNA binding site [nucleotide binding]; other site 1041809004179 Septum formation initiator; Region: DivIC; cl17659 1041809004180 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 1041809004181 YabP family; Region: YabP; cl06766 1041809004182 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1041809004183 RNA binding surface [nucleotide binding]; other site 1041809004184 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1041809004185 IHF dimer interface [polypeptide binding]; other site 1041809004186 IHF - DNA interface [nucleotide binding]; other site 1041809004187 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1041809004188 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1041809004189 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1041809004190 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1041809004191 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1041809004192 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1041809004193 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1041809004194 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1041809004195 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1041809004196 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041809004197 ATP binding site [chemical binding]; other site 1041809004198 putative Mg++ binding site [ion binding]; other site 1041809004199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041809004200 nucleotide binding region [chemical binding]; other site 1041809004201 ATP-binding site [chemical binding]; other site 1041809004202 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1041809004203 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1041809004204 putative active site [active] 1041809004205 catalytic residue [active] 1041809004206 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1041809004207 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1041809004208 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041809004209 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1041809004210 dimerization interface [polypeptide binding]; other site 1041809004211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041809004212 dimer interface [polypeptide binding]; other site 1041809004213 phosphorylation site [posttranslational modification] 1041809004214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041809004215 ATP binding site [chemical binding]; other site 1041809004216 Mg2+ binding site [ion binding]; other site 1041809004217 G-X-G motif; other site 1041809004218 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1041809004219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041809004220 active site 1041809004221 phosphorylation site [posttranslational modification] 1041809004222 intermolecular recognition site; other site 1041809004223 dimerization interface [polypeptide binding]; other site 1041809004224 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1041809004225 DNA binding site [nucleotide binding] 1041809004226 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1041809004227 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1041809004228 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041809004229 active site 1041809004230 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1041809004231 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1041809004232 Substrate binding site; other site 1041809004233 Mg++ binding site; other site 1041809004234 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1041809004235 putative trimer interface [polypeptide binding]; other site 1041809004236 putative CoA binding site [chemical binding]; other site 1041809004237 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1041809004238 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1041809004239 putative dimer interface [polypeptide binding]; other site 1041809004240 putative anticodon binding site; other site 1041809004241 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1041809004242 homodimer interface [polypeptide binding]; other site 1041809004243 motif 1; other site 1041809004244 motif 2; other site 1041809004245 active site 1041809004246 motif 3; other site 1041809004247 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1041809004248 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1041809004249 active site 1041809004250 metal binding site [ion binding]; metal-binding site 1041809004251 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1041809004252 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1041809004253 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1041809004254 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1041809004255 regulatory protein SpoVG; Reviewed; Region: PRK13259 1041809004256 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1041809004257 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1041809004258 interface (dimer of trimers) [polypeptide binding]; other site 1041809004259 Substrate-binding/catalytic site; other site 1041809004260 Zn-binding sites [ion binding]; other site 1041809004261 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1041809004262 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1041809004263 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1041809004264 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1041809004265 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1041809004266 Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair]; Region: COG1658 1041809004267 active site 1041809004268 metal binding site [ion binding]; metal-binding site 1041809004269 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1041809004270 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1041809004271 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1041809004272 G5 domain; Region: G5; pfam07501 1041809004273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1041809004274 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1041809004275 active site 1041809004276 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1041809004277 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1041809004278 PYR/PP interface [polypeptide binding]; other site 1041809004279 dimer interface [polypeptide binding]; other site 1041809004280 TPP binding site [chemical binding]; other site 1041809004281 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1041809004282 transketolase; Reviewed; Region: PRK05899 1041809004283 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1041809004284 TPP-binding site [chemical binding]; other site 1041809004285 dimer interface [polypeptide binding]; other site 1041809004286 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1041809004287 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1041809004288 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1041809004289 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1041809004290 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 1041809004291 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1041809004292 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1041809004293 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1041809004294 hypothetical protein; Provisional; Region: PRK13661 1041809004295 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1041809004296 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1041809004297 Walker A/P-loop; other site 1041809004298 ATP binding site [chemical binding]; other site 1041809004299 Q-loop/lid; other site 1041809004300 ABC transporter signature motif; other site 1041809004301 Walker B; other site 1041809004302 D-loop; other site 1041809004303 H-loop/switch region; other site 1041809004304 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1041809004305 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1041809004306 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1041809004307 Walker A/P-loop; other site 1041809004308 ATP binding site [chemical binding]; other site 1041809004309 Q-loop/lid; other site 1041809004310 ABC transporter signature motif; other site 1041809004311 Walker B; other site 1041809004312 D-loop; other site 1041809004313 H-loop/switch region; other site 1041809004314 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1041809004315 Sulfatase; Region: Sulfatase; cl17466 1041809004316 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1041809004317 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1041809004318 active site 1041809004319 HIGH motif; other site 1041809004320 KMSKS motif; other site 1041809004321 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1041809004322 tRNA binding surface [nucleotide binding]; other site 1041809004323 anticodon binding site; other site 1041809004324 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1041809004325 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1041809004326 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1041809004327 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 1041809004328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041809004329 Walker A motif; other site 1041809004330 ATP binding site [chemical binding]; other site 1041809004331 Walker B motif; other site 1041809004332 arginine finger; other site 1041809004333 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1041809004334 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1041809004335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1041809004336 non-specific DNA binding site [nucleotide binding]; other site 1041809004337 salt bridge; other site 1041809004338 sequence-specific DNA binding site [nucleotide binding]; other site 1041809004339 Cupin domain; Region: Cupin_2; pfam07883 1041809004340 replicative DNA helicase; Region: DnaB; TIGR00665 1041809004341 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1041809004342 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1041809004343 Walker A motif; other site 1041809004344 ATP binding site [chemical binding]; other site 1041809004345 Walker B motif; other site 1041809004346 DNA binding loops [nucleotide binding] 1041809004347 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 1041809004348 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 1041809004349 hypothetical protein; Provisional; Region: PRK05590 1041809004350 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1041809004351 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1041809004352 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1041809004353 hinge; other site 1041809004354 active site 1041809004355 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1041809004356 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1041809004357 active site 1041809004358 catalytic residues [active] 1041809004359 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1041809004360 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1041809004361 Peptidase family M23; Region: Peptidase_M23; pfam01551 1041809004362 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1041809004363 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1041809004364 DNA replication protein DnaC; Validated; Region: PRK06835 1041809004365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041809004366 Walker A motif; other site 1041809004367 ATP binding site [chemical binding]; other site 1041809004368 Walker B motif; other site 1041809004369 arginine finger; other site 1041809004370 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1041809004371 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1041809004372 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1041809004373 dimer interface [polypeptide binding]; other site 1041809004374 ssDNA binding site [nucleotide binding]; other site 1041809004375 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1041809004376 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1041809004377 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 1041809004378 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1041809004379 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1041809004380 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1041809004381 catalytic residue [active] 1041809004382 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1041809004383 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1041809004384 P-loop; other site 1041809004385 Magnesium ion binding site [ion binding]; other site 1041809004386 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1041809004387 Magnesium ion binding site [ion binding]; other site 1041809004388 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1041809004389 ParB-like nuclease domain; Region: ParB; smart00470 1041809004390 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1041809004391 amidase catalytic site [active] 1041809004392 Zn binding residues [ion binding]; other site 1041809004393 substrate binding site [chemical binding]; other site 1041809004394 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1041809004395 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1041809004396 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1041809004397 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1041809004398 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1041809004399 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1041809004400 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1041809004401 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1041809004402 G1 box; other site 1041809004403 GTP/Mg2+ binding site [chemical binding]; other site 1041809004404 Switch I region; other site 1041809004405 G2 box; other site 1041809004406 Switch II region; other site 1041809004407 G3 box; other site 1041809004408 G4 box; other site 1041809004409 G5 box; other site 1041809004410 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1041809004411 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1041809004412 Haemolytic domain; Region: Haemolytic; pfam01809 1041809004413 ribonuclease P; Reviewed; Region: rnpA; PRK00499