-- dump date 20140619_022433 -- class Genbank::misc_feature -- table misc_feature_note -- id note 511995000001 Initiator Replication protein; Region: Rep_3; pfam01051 511995000002 Protein of unknown function (DUF805); Region: DUF805; pfam05656 511995000003 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 511995000004 CHC2 zinc finger; Region: zf-CHC2; cl17510 511995000005 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 511995000006 active site 511995000007 metal binding site [ion binding]; metal-binding site 511995000008 interdomain interaction site; other site 511995000009 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 511995000010 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 511995000011 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 511995000012 active site 511995000013 metal binding site [ion binding]; metal-binding site 511995000014 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 511995000015 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 511995000016 catalytic residues [active] 511995000017 catalytic nucleophile [active] 511995000018 Presynaptic Site I dimer interface [polypeptide binding]; other site 511995000019 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 511995000020 Synaptic Flat tetramer interface [polypeptide binding]; other site 511995000021 Synaptic Site I dimer interface [polypeptide binding]; other site 511995000022 DNA binding site [nucleotide binding] 511995000023 Initiator Replication protein; Region: Rep_3; pfam01051 511995000024 Initiator Replication protein; Region: Rep_3; pfam01051 511995000025 Protein of unknown function (DUF805); Region: DUF805; pfam05656 511995000026 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 511995000027 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 511995000028 generic binding surface II; other site 511995000029 ssDNA binding site; other site 511995000030 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511995000031 ATP binding site [chemical binding]; other site 511995000032 putative Mg++ binding site [ion binding]; other site 511995000033 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511995000034 nucleotide binding region [chemical binding]; other site 511995000035 ATP-binding site [chemical binding]; other site 511995000036 hypothetical protein; Region: PHA01623 511995000037 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 511995000038 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 511995000039 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511995000040 Magnesium ion binding site [ion binding]; other site 511995000041 nitrogenase reductase; Reviewed; Region: nifH; PRK13233 511995000042 replicative DNA helicase; Region: DnaB; TIGR00665 511995000043 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 511995000044 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 511995000045 Walker A motif; other site 511995000046 ATP binding site [chemical binding]; other site 511995000047 Walker B motif; other site 511995000048 DNA binding loops [nucleotide binding] 511995000049 Initiator Replication protein; Region: Rep_3; pfam01051 511995000050 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 511995000051 Protein of unknown function (DUF805); Region: DUF805; pfam05656 511995000052 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 511995000053 Peptidase family M23; Region: Peptidase_M23; pfam01551 511995000054 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 511995000055 IHF dimer interface [polypeptide binding]; other site 511995000056 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 511995000057 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 511995000058 active site 511995000059 metal binding site [ion binding]; metal-binding site 511995000060 multiple promoter invertase; Provisional; Region: mpi; PRK13413 511995000061 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 511995000062 catalytic residues [active] 511995000063 catalytic nucleophile [active] 511995000064 Presynaptic Site I dimer interface [polypeptide binding]; other site 511995000065 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 511995000066 Synaptic Flat tetramer interface [polypeptide binding]; other site 511995000067 Synaptic Site I dimer interface [polypeptide binding]; other site 511995000068 DNA binding site [nucleotide binding] 511995000069 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 511995000070 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 511995000071 IHF dimer interface [polypeptide binding]; other site 511995000072 Initiator Replication protein; Region: Rep_3; pfam01051 511995000073 MobA/MobL family; Region: MobA_MobL; pfam03389 511995000074 Initiator Replication protein; Region: Rep_3; pfam01051 511995000075 Initiator Replication protein; Region: Rep_3; pfam01051 511995000076 Protein of unknown function (DUF805); Region: DUF805; pfam05656 511995000077 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 511995000078 multiple promoter invertase; Provisional; Region: mpi; PRK13413 511995000079 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 511995000080 catalytic residues [active] 511995000081 catalytic nucleophile [active] 511995000082 Presynaptic Site I dimer interface [polypeptide binding]; other site 511995000083 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 511995000084 Synaptic Flat tetramer interface [polypeptide binding]; other site 511995000085 Synaptic Site I dimer interface [polypeptide binding]; other site 511995000086 DNA binding site [nucleotide binding] 511995000087 Initiator Replication protein; Region: Rep_3; pfam01051 511995000088 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 511995000089 DnaA N-terminal domain; Region: DnaA_N; pfam11638 511995000090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511995000091 Walker A motif; other site 511995000092 ATP binding site [chemical binding]; other site 511995000093 Walker B motif; other site 511995000094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 511995000095 arginine finger; other site 511995000096 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 511995000097 DnaA box-binding interface [nucleotide binding]; other site 511995000098 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 511995000099 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 511995000100 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 511995000101 KMSK motif region; other site 511995000102 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 511995000103 tRNA binding surface [nucleotide binding]; other site 511995000104 anticodon binding site; other site 511995000105 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 511995000106 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 511995000107 transcription termination factor Rho; Provisional; Region: PRK12608 511995000108 RNA binding site [nucleotide binding]; other site 511995000109 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 511995000110 multimer interface [polypeptide binding]; other site 511995000111 Walker A motif; other site 511995000112 ATP binding site [chemical binding]; other site 511995000113 Walker B motif; other site 511995000114 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 511995000115 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 511995000116 TilS substrate C-terminal domain; Region: TilS_C; smart00977 511995000117 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 511995000118 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 511995000119 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 511995000120 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 511995000121 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 511995000122 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 511995000123 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 511995000124 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 511995000125 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 511995000126 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 511995000127 DNA binding site [nucleotide binding] 511995000128 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 511995000129 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 511995000130 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 511995000131 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 511995000132 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 511995000133 RPB12 interaction site [polypeptide binding]; other site 511995000134 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 511995000135 RPB11 interaction site [polypeptide binding]; other site 511995000136 RPB12 interaction site [polypeptide binding]; other site 511995000137 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 511995000138 RPB3 interaction site [polypeptide binding]; other site 511995000139 RPB1 interaction site [polypeptide binding]; other site 511995000140 RPB11 interaction site [polypeptide binding]; other site 511995000141 RPB10 interaction site [polypeptide binding]; other site 511995000142 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 511995000143 core dimer interface [polypeptide binding]; other site 511995000144 peripheral dimer interface [polypeptide binding]; other site 511995000145 L10 interface [polypeptide binding]; other site 511995000146 L11 interface [polypeptide binding]; other site 511995000147 putative EF-Tu interaction site [polypeptide binding]; other site 511995000148 putative EF-G interaction site [polypeptide binding]; other site 511995000149 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 511995000150 23S rRNA interface [nucleotide binding]; other site 511995000151 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 511995000152 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 511995000153 mRNA/rRNA interface [nucleotide binding]; other site 511995000154 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 511995000155 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 511995000156 23S rRNA interface [nucleotide binding]; other site 511995000157 L7/L12 interface [polypeptide binding]; other site 511995000158 putative thiostrepton binding site; other site 511995000159 L25 interface [polypeptide binding]; other site 511995000160 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 511995000161 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 511995000162 putative homodimer interface [polypeptide binding]; other site 511995000163 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 511995000164 heterodimer interface [polypeptide binding]; other site 511995000165 homodimer interface [polypeptide binding]; other site 511995000166 elongation factor Tu; Reviewed; Region: PRK12735 511995000167 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 511995000168 G1 box; other site 511995000169 GEF interaction site [polypeptide binding]; other site 511995000170 GTP/Mg2+ binding site [chemical binding]; other site 511995000171 Switch I region; other site 511995000172 G2 box; other site 511995000173 G3 box; other site 511995000174 Switch II region; other site 511995000175 G4 box; other site 511995000176 G5 box; other site 511995000177 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 511995000178 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 511995000179 Antibiotic Binding Site [chemical binding]; other site 511995000180 dihydroorotase; Reviewed; Region: PRK09236 511995000181 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511995000182 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 511995000183 active site 511995000184 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 511995000185 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 511995000186 Ligand binding site; other site 511995000187 Putative Catalytic site; other site 511995000188 DXD motif; other site 511995000189 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 511995000190 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 511995000191 putative ligand binding site [chemical binding]; other site 511995000192 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 511995000193 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 511995000194 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 511995000195 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 511995000196 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 511995000197 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 511995000198 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 511995000199 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 511995000200 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 511995000201 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511995000202 Zn2+ binding site [ion binding]; other site 511995000203 Mg2+ binding site [ion binding]; other site 511995000204 pantothenate kinase; Reviewed; Region: PRK13320 511995000205 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 511995000206 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 511995000207 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 511995000208 active site 511995000209 Riboflavin kinase; Region: Flavokinase; smart00904 511995000210 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 511995000211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511995000212 ATP binding site [chemical binding]; other site 511995000213 Mg2+ binding site [ion binding]; other site 511995000214 G-X-G motif; other site 511995000215 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 511995000216 anchoring element; other site 511995000217 dimer interface [polypeptide binding]; other site 511995000218 ATP binding site [chemical binding]; other site 511995000219 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 511995000220 active site 511995000221 putative metal-binding site [ion binding]; other site 511995000222 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 511995000223 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 511995000224 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 511995000225 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 511995000226 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 511995000227 dihydrodipicolinate synthase; Region: dapA; TIGR00674 511995000228 dimer interface [polypeptide binding]; other site 511995000229 active site 511995000230 catalytic residue [active] 511995000231 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 511995000232 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 511995000233 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 511995000234 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 511995000235 histidinol dehydrogenase; Region: hisD; TIGR00069 511995000236 NAD binding site [chemical binding]; other site 511995000237 dimerization interface [polypeptide binding]; other site 511995000238 product binding site; other site 511995000239 substrate binding site [chemical binding]; other site 511995000240 zinc binding site [ion binding]; other site 511995000241 catalytic residues [active] 511995000242 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 511995000243 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511995000244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511995000245 homodimer interface [polypeptide binding]; other site 511995000246 catalytic residue [active] 511995000247 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 511995000248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511995000249 active site 511995000250 motif I; other site 511995000251 motif II; other site 511995000252 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 511995000253 putative active site pocket [active] 511995000254 4-fold oligomerization interface [polypeptide binding]; other site 511995000255 metal binding residues [ion binding]; metal-binding site 511995000256 3-fold/trimer interface [polypeptide binding]; other site 511995000257 Cell division protein ZapA; Region: ZapA; pfam05164 511995000258 phosphodiesterase; Provisional; Region: PRK12704 511995000259 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511995000260 Zn2+ binding site [ion binding]; other site 511995000261 Mg2+ binding site [ion binding]; other site 511995000262 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 511995000263 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 511995000264 putative active site [active] 511995000265 oxyanion strand; other site 511995000266 catalytic triad [active] 511995000267 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 511995000268 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 511995000269 catalytic residues [active] 511995000270 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 511995000271 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 511995000272 substrate binding site [chemical binding]; other site 511995000273 glutamase interaction surface [polypeptide binding]; other site 511995000274 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 511995000275 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 511995000276 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 511995000277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511995000278 catalytic residue [active] 511995000279 recombinase A; Provisional; Region: recA; PRK09354 511995000280 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 511995000281 hexamer interface [polypeptide binding]; other site 511995000282 Walker A motif; other site 511995000283 ATP binding site [chemical binding]; other site 511995000284 Walker B motif; other site 511995000285 TPR repeat; Region: TPR_11; pfam13414 511995000286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511995000287 binding surface 511995000288 TPR motif; other site 511995000289 TPR repeat; Region: TPR_11; pfam13414 511995000290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511995000291 binding surface 511995000292 TPR motif; other site 511995000293 Tetratricopeptide repeat; Region: TPR_12; pfam13424 511995000294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511995000295 binding surface 511995000296 TPR motif; other site 511995000297 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 511995000298 Putative zinc ribbon domain; Region: DUF164; pfam02591 511995000299 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 511995000300 Uncharacterized conserved protein [Function unknown]; Region: COG0327 511995000301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 511995000302 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 511995000303 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 511995000304 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511995000305 minor groove reading motif; other site 511995000306 helix-hairpin-helix signature motif; other site 511995000307 substrate binding pocket [chemical binding]; other site 511995000308 active site 511995000309 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 511995000310 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 511995000311 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 511995000312 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 511995000313 dimer interface [polypeptide binding]; other site 511995000314 motif 1; other site 511995000315 active site 511995000316 motif 2; other site 511995000317 motif 3; other site 511995000318 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 511995000319 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 511995000320 ATP binding site [chemical binding]; other site 511995000321 Mg++ binding site [ion binding]; other site 511995000322 motif III; other site 511995000323 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511995000324 nucleotide binding region [chemical binding]; other site 511995000325 ATP-binding site [chemical binding]; other site 511995000326 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 511995000327 RNA binding site [nucleotide binding]; other site 511995000328 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 511995000329 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 511995000330 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 511995000331 Recombination protein O N terminal; Region: RecO_N; pfam11967 511995000332 Recombination protein O C terminal; Region: RecO_C; pfam02565 511995000333 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 511995000334 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 511995000335 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 511995000336 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 511995000337 transcription termination factor NusA; Region: NusA; TIGR01953 511995000338 NusA N-terminal domain; Region: NusA_N; pfam08529 511995000339 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 511995000340 RNA binding site [nucleotide binding]; other site 511995000341 homodimer interface [polypeptide binding]; other site 511995000342 NusA-like KH domain; Region: KH_5; pfam13184 511995000343 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 511995000344 G-X-X-G motif; other site 511995000345 translation initiation factor IF-2; Region: IF-2; TIGR00487 511995000346 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 511995000347 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 511995000348 G1 box; other site 511995000349 putative GEF interaction site [polypeptide binding]; other site 511995000350 GTP/Mg2+ binding site [chemical binding]; other site 511995000351 Switch I region; other site 511995000352 G2 box; other site 511995000353 G3 box; other site 511995000354 Switch II region; other site 511995000355 G4 box; other site 511995000356 G5 box; other site 511995000357 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 511995000358 Translation-initiation factor 2; Region: IF-2; pfam11987 511995000359 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 511995000360 DNA repair protein RadA; Provisional; Region: PRK11823 511995000361 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 511995000362 Walker A motif/ATP binding site; other site 511995000363 ATP binding site [chemical binding]; other site 511995000364 Walker B motif; other site 511995000365 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 511995000366 recombination factor protein RarA; Reviewed; Region: PRK13342 511995000367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511995000368 Walker A motif; other site 511995000369 ATP binding site [chemical binding]; other site 511995000370 Walker B motif; other site 511995000371 arginine finger; other site 511995000372 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 511995000373 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 511995000374 active site 511995000375 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 511995000376 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 511995000377 NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008 511995000378 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 511995000379 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 511995000380 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009 511995000381 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 511995000382 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 511995000383 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 511995000384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511995000385 putative substrate translocation pore; other site 511995000386 Preprotein translocase SecG subunit; Region: SecG; pfam03840 511995000387 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511995000388 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 511995000389 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511995000390 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511995000391 dihydropteroate synthase; Region: DHPS; TIGR01496 511995000392 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 511995000393 substrate binding pocket [chemical binding]; other site 511995000394 dimer interface [polypeptide binding]; other site 511995000395 inhibitor binding site; inhibition site 511995000396 Uncharacterized conserved protein [Function unknown]; Region: COG1624 511995000397 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 511995000398 Transglycosylase; Region: Transgly; pfam00912 511995000399 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 511995000400 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 511995000401 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 511995000402 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 511995000403 alphaNTD homodimer interface [polypeptide binding]; other site 511995000404 alphaNTD - beta interaction site [polypeptide binding]; other site 511995000405 alphaNTD - beta' interaction site [polypeptide binding]; other site 511995000406 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 511995000407 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 511995000408 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 511995000409 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511995000410 RNA binding surface [nucleotide binding]; other site 511995000411 30S ribosomal protein S11; Validated; Region: PRK05309 511995000412 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 511995000413 30S ribosomal protein S13; Region: bact_S13; TIGR03631 511995000414 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 511995000415 rRNA binding site [nucleotide binding]; other site 511995000416 predicted 30S ribosome binding site; other site 511995000417 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 511995000418 active site 511995000419 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 511995000420 SecY translocase; Region: SecY; pfam00344 511995000421 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 511995000422 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 511995000423 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 511995000424 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 511995000425 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 511995000426 5S rRNA interface [nucleotide binding]; other site 511995000427 L27 interface [polypeptide binding]; other site 511995000428 23S rRNA interface [nucleotide binding]; other site 511995000429 L5 interface [polypeptide binding]; other site 511995000430 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 511995000431 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 511995000432 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 511995000433 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 511995000434 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 511995000435 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 511995000436 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 511995000437 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 511995000438 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 511995000439 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 511995000440 RNA binding site [nucleotide binding]; other site 511995000441 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 511995000442 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 511995000443 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 511995000444 23S rRNA interface [nucleotide binding]; other site 511995000445 putative translocon interaction site; other site 511995000446 signal recognition particle (SRP54) interaction site; other site 511995000447 L23 interface [polypeptide binding]; other site 511995000448 trigger factor interaction site; other site 511995000449 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 511995000450 23S rRNA interface [nucleotide binding]; other site 511995000451 5S rRNA interface [nucleotide binding]; other site 511995000452 putative antibiotic binding site [chemical binding]; other site 511995000453 L25 interface [polypeptide binding]; other site 511995000454 L27 interface [polypeptide binding]; other site 511995000455 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 511995000456 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 511995000457 G-X-X-G motif; other site 511995000458 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 511995000459 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 511995000460 putative translocon binding site; other site 511995000461 protein-rRNA interface [nucleotide binding]; other site 511995000462 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 511995000463 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 511995000464 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 511995000465 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 511995000466 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 511995000467 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 511995000468 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 511995000469 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 511995000470 elongation factor G; Reviewed; Region: PRK12739 511995000471 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 511995000472 G1 box; other site 511995000473 putative GEF interaction site [polypeptide binding]; other site 511995000474 GTP/Mg2+ binding site [chemical binding]; other site 511995000475 Switch I region; other site 511995000476 G2 box; other site 511995000477 G3 box; other site 511995000478 Switch II region; other site 511995000479 G4 box; other site 511995000480 G5 box; other site 511995000481 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 511995000482 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 511995000483 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 511995000484 30S ribosomal protein S7; Validated; Region: PRK05302 511995000485 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 511995000486 S17 interaction site [polypeptide binding]; other site 511995000487 S8 interaction site; other site 511995000488 16S rRNA interaction site [nucleotide binding]; other site 511995000489 streptomycin interaction site [chemical binding]; other site 511995000490 23S rRNA interaction site [nucleotide binding]; other site 511995000491 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 511995000492 ribonuclease Z; Region: RNase_Z; TIGR02651 511995000493 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 511995000494 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 511995000495 active site 511995000496 HIGH motif; other site 511995000497 KMSKS motif; other site 511995000498 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 511995000499 tRNA binding surface [nucleotide binding]; other site 511995000500 anticodon binding site; other site 511995000501 prolyl-tRNA synthetase; Provisional; Region: PRK08661 511995000502 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 511995000503 dimer interface [polypeptide binding]; other site 511995000504 motif 1; other site 511995000505 active site 511995000506 motif 2; other site 511995000507 motif 3; other site 511995000508 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 511995000509 anticodon binding site; other site 511995000510 zinc-binding site [ion binding]; other site 511995000511 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 511995000512 23S rRNA binding site [nucleotide binding]; other site 511995000513 L21 binding site [polypeptide binding]; other site 511995000514 L13 binding site [polypeptide binding]; other site 511995000515 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 511995000516 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 511995000517 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 511995000518 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 511995000519 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 511995000520 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 511995000521 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 511995000522 active site 511995000523 dimer interface [polypeptide binding]; other site 511995000524 motif 1; other site 511995000525 motif 2; other site 511995000526 motif 3; other site 511995000527 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 511995000528 anticodon binding site; other site 511995000529 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 511995000530 C-terminal peptidase (prc); Region: prc; TIGR00225 511995000531 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 511995000532 protein binding site [polypeptide binding]; other site 511995000533 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 511995000534 Catalytic dyad [active] 511995000535 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 511995000536 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 511995000537 active site 511995000538 (T/H)XGH motif; other site 511995000539 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 511995000540 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 511995000541 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 511995000542 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 511995000543 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 511995000544 putative active site [active] 511995000545 putative catalytic site [active] 511995000546 putative DNA binding site [nucleotide binding]; other site 511995000547 putative phosphate binding site [ion binding]; other site 511995000548 metal binding site A [ion binding]; metal-binding site 511995000549 putative AP binding site [nucleotide binding]; other site 511995000550 putative metal binding site B [ion binding]; other site 511995000551 arginine decarboxylase; Provisional; Region: PRK05354 511995000552 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 511995000553 dimer interface [polypeptide binding]; other site 511995000554 active site 511995000555 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511995000556 catalytic residues [active] 511995000557 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 511995000558 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 511995000559 substrate binding site; other site 511995000560 dimer interface; other site 511995000561 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 511995000562 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 511995000563 generic binding surface II; other site 511995000564 ssDNA binding site; other site 511995000565 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511995000566 ATP binding site [chemical binding]; other site 511995000567 putative Mg++ binding site [ion binding]; other site 511995000568 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511995000569 nucleotide binding region [chemical binding]; other site 511995000570 ATP-binding site [chemical binding]; other site 511995000571 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 511995000572 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 511995000573 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 511995000574 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511995000575 RNA binding surface [nucleotide binding]; other site 511995000576 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 511995000577 active site 511995000578 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 511995000579 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 511995000580 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511995000581 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 511995000582 NAD synthetase; Reviewed; Region: nadE; PRK02628 511995000583 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 511995000584 multimer interface [polypeptide binding]; other site 511995000585 active site 511995000586 catalytic triad [active] 511995000587 protein interface 1 [polypeptide binding]; other site 511995000588 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 511995000589 homodimer interface [polypeptide binding]; other site 511995000590 NAD binding pocket [chemical binding]; other site 511995000591 ATP binding pocket [chemical binding]; other site 511995000592 Mg binding site [ion binding]; other site 511995000593 active-site loop [active] 511995000594 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 511995000595 Peptidase family M23; Region: Peptidase_M23; pfam01551 511995000596 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511995000597 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 511995000598 active site 511995000599 multimer interface [polypeptide binding]; other site 511995000600 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 511995000601 FMN binding site [chemical binding]; other site 511995000602 active site 511995000603 catalytic residues [active] 511995000604 substrate binding site [chemical binding]; other site 511995000605 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 511995000606 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 511995000607 active site 511995000608 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511995000609 dimer interface [polypeptide binding]; other site 511995000610 substrate binding site [chemical binding]; other site 511995000611 catalytic residues [active] 511995000612 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 511995000613 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 511995000614 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 511995000615 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 511995000616 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 511995000617 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 511995000618 LytB protein; Region: LYTB; cl00507 511995000619 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 511995000620 GTP-binding protein Der; Reviewed; Region: PRK00093 511995000621 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 511995000622 G1 box; other site 511995000623 GTP/Mg2+ binding site [chemical binding]; other site 511995000624 Switch I region; other site 511995000625 G2 box; other site 511995000626 Switch II region; other site 511995000627 G3 box; other site 511995000628 G4 box; other site 511995000629 G5 box; other site 511995000630 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 511995000631 G1 box; other site 511995000632 GTP/Mg2+ binding site [chemical binding]; other site 511995000633 Switch I region; other site 511995000634 G2 box; other site 511995000635 G3 box; other site 511995000636 Switch II region; other site 511995000637 G4 box; other site 511995000638 G5 box; other site 511995000639 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 511995000640 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 511995000641 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 511995000642 RNA/DNA hybrid binding site [nucleotide binding]; other site 511995000643 active site 511995000644 primosome assembly protein PriA; Validated; Region: PRK05580 511995000645 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511995000646 putative Mg++ binding site [ion binding]; other site 511995000647 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 511995000648 putative active site [active] 511995000649 catalytic residue [active] 511995000650 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 511995000651 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 511995000652 5S rRNA interface [nucleotide binding]; other site 511995000653 CTC domain interface [polypeptide binding]; other site 511995000654 L16 interface [polypeptide binding]; other site 511995000655 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 511995000656 gamma subunit interface [polypeptide binding]; other site 511995000657 LBP interface [polypeptide binding]; other site 511995000658 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 511995000659 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 511995000660 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 511995000661 alpha subunit interaction interface [polypeptide binding]; other site 511995000662 Walker A motif; other site 511995000663 ATP binding site [chemical binding]; other site 511995000664 Walker B motif; other site 511995000665 inhibitor binding site; inhibition site 511995000666 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 511995000667 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 511995000668 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511995000669 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 511995000670 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 511995000671 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511995000672 putative DNA binding site [nucleotide binding]; other site 511995000673 putative Zn2+ binding site [ion binding]; other site 511995000674 AsnC family; Region: AsnC_trans_reg; pfam01037 511995000675 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 511995000676 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 511995000677 FeoA domain; Region: FeoA; pfam04023 511995000678 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 511995000679 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 511995000680 G1 box; other site 511995000681 GTP/Mg2+ binding site [chemical binding]; other site 511995000682 Switch I region; other site 511995000683 G2 box; other site 511995000684 G3 box; other site 511995000685 Switch II region; other site 511995000686 G4 box; other site 511995000687 G5 box; other site 511995000688 Nucleoside recognition; Region: Gate; pfam07670 511995000689 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 511995000690 Nucleoside recognition; Region: Gate; pfam07670 511995000691 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 511995000692 active site 511995000693 putative DNA-binding cleft [nucleotide binding]; other site 511995000694 dimer interface [polypeptide binding]; other site 511995000695 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 511995000696 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 511995000697 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 511995000698 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511995000699 ATP binding site [chemical binding]; other site 511995000700 putative Mg++ binding site [ion binding]; other site 511995000701 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511995000702 nucleotide binding region [chemical binding]; other site 511995000703 ATP-binding site [chemical binding]; other site 511995000704 homoserine O-succinyltransferase; Provisional; Region: PRK05368 511995000705 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 511995000706 proposed active site lysine [active] 511995000707 conserved cys residue [active] 511995000708 heat shock protein 90; Provisional; Region: PRK05218 511995000709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511995000710 ATP binding site [chemical binding]; other site 511995000711 Mg2+ binding site [ion binding]; other site 511995000712 G-X-G motif; other site 511995000713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511995000714 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511995000715 Walker A motif; other site 511995000716 ATP binding site [chemical binding]; other site 511995000717 Walker B motif; other site 511995000718 arginine finger; other site 511995000719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511995000720 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511995000721 Walker A motif; other site 511995000722 ATP binding site [chemical binding]; other site 511995000723 Walker B motif; other site 511995000724 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 511995000725 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 511995000726 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 511995000727 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511995000728 ABC-ATPase subunit interface; other site 511995000729 dimer interface [polypeptide binding]; other site 511995000730 putative PBP binding regions; other site 511995000731 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 511995000732 Protein export membrane protein; Region: SecD_SecF; cl14618 511995000733 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 511995000734 Protein export membrane protein; Region: SecD_SecF; pfam02355 511995000735 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 511995000736 Thiamine pyrophosphokinase; Region: TPK; cd07995 511995000737 active site 511995000738 dimerization interface [polypeptide binding]; other site 511995000739 thiamine binding site [chemical binding]; other site 511995000740 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 511995000741 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 511995000742 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 511995000743 dimerization interface 3.5A [polypeptide binding]; other site 511995000744 active site 511995000745 Protein of unknown function (DUF3256); Region: DUF3256; pfam11644 511995000746 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 511995000747 tetramerization interface [polypeptide binding]; other site 511995000748 active site 511995000749 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 511995000750 Found in ATP-dependent protease La (LON); Region: LON; smart00464 511995000751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511995000752 Walker A motif; other site 511995000753 ATP binding site [chemical binding]; other site 511995000754 Walker B motif; other site 511995000755 arginine finger; other site 511995000756 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 511995000757 glycyl-tRNA synthetase; Provisional; Region: PRK04173 511995000758 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 511995000759 motif 1; other site 511995000760 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 511995000761 active site 511995000762 motif 2; other site 511995000763 motif 3; other site 511995000764 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 511995000765 anticodon binding site; other site 511995000766 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 511995000767 propionate/acetate kinase; Provisional; Region: PRK12379 511995000768 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 511995000769 FMN binding site [chemical binding]; other site 511995000770 dimer interface [polypeptide binding]; other site 511995000771 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 511995000772 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 511995000773 putative active site [active] 511995000774 substrate binding site [chemical binding]; other site 511995000775 putative cosubstrate binding site; other site 511995000776 catalytic site [active] 511995000777 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 511995000778 substrate binding site [chemical binding]; other site 511995000779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511995000780 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511995000781 Walker A motif; other site 511995000782 ATP binding site [chemical binding]; other site 511995000783 Walker B motif; other site 511995000784 arginine finger; other site 511995000785 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 511995000786 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 511995000787 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 511995000788 CoA-binding site [chemical binding]; other site 511995000789 ATP-binding [chemical binding]; other site 511995000790 Preprotein translocase subunit; Region: YajC; pfam02699 511995000791 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 511995000792 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511995000793 HIGH motif; other site 511995000794 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511995000795 active site 511995000796 KMSKS motif; other site 511995000797 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 511995000798 Rubredoxin [Energy production and conversion]; Region: COG1773 511995000799 iron binding site [ion binding]; other site 511995000800 Rubrerythrin [Energy production and conversion]; Region: COG1592 511995000801 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 511995000802 diiron binding motif [ion binding]; other site 511995000803 CTP synthetase; Validated; Region: pyrG; PRK05380 511995000804 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 511995000805 Catalytic site [active] 511995000806 active site 511995000807 UTP binding site [chemical binding]; other site 511995000808 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 511995000809 active site 511995000810 putative oxyanion hole; other site 511995000811 catalytic triad [active] 511995000812 membrane protein insertase; Provisional; Region: PRK01318 511995000813 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 511995000814 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 511995000815 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 511995000816 FAD binding pocket [chemical binding]; other site 511995000817 FAD binding motif [chemical binding]; other site 511995000818 phosphate binding motif [ion binding]; other site 511995000819 beta-alpha-beta structure motif; other site 511995000820 NAD binding pocket [chemical binding]; other site 511995000821 Iron coordination center [ion binding]; other site 511995000822 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 511995000823 mannonate dehydratase; Provisional; Region: PRK03906 511995000824 mannonate dehydratase; Region: uxuA; TIGR00695 511995000825 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 511995000826 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 511995000827 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 511995000828 prephenate dehydrogenase; Validated; Region: PRK08507 511995000829 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 511995000830 Chorismate mutase type II; Region: CM_2; smart00830 511995000831 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 511995000832 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511995000833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511995000834 homodimer interface [polypeptide binding]; other site 511995000835 catalytic residue [active] 511995000836 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 511995000837 Prephenate dehydratase; Region: PDT; pfam00800 511995000838 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 511995000839 putative L-Phe binding site [chemical binding]; other site 511995000840 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 511995000841 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 511995000842 intersubunit interface [polypeptide binding]; other site 511995000843 active site 511995000844 zinc binding site [ion binding]; other site 511995000845 Na+ binding site [ion binding]; other site 511995000846 DNA topoisomerase I; Validated; Region: PRK06599 511995000847 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 511995000848 active site 511995000849 interdomain interaction site; other site 511995000850 putative metal-binding site [ion binding]; other site 511995000851 nucleotide binding site [chemical binding]; other site 511995000852 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 511995000853 domain I; other site 511995000854 DNA binding groove [nucleotide binding] 511995000855 phosphate binding site [ion binding]; other site 511995000856 domain II; other site 511995000857 domain III; other site 511995000858 nucleotide binding site [chemical binding]; other site 511995000859 catalytic site [active] 511995000860 domain IV; other site 511995000861 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 511995000862 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 511995000863 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 511995000864 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 511995000865 putative dimer interface [polypeptide binding]; other site 511995000866 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 511995000867 Peptidase family M23; Region: Peptidase_M23; pfam01551 511995000868 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 511995000869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511995000870 binding surface 511995000871 TPR motif; other site 511995000872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511995000873 binding surface 511995000874 Tetratricopeptide repeat; Region: TPR_16; pfam13432 511995000875 TPR motif; other site 511995000876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511995000877 TPR motif; other site 511995000878 binding surface 511995000879 Tetratricopeptide repeat; Region: TPR_12; pfam13424 511995000880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511995000881 binding surface 511995000882 TPR repeat; Region: TPR_11; pfam13414 511995000883 TPR motif; other site 511995000884 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 511995000885 trimer interface [polypeptide binding]; other site 511995000886 active site 511995000887 ribonuclease P; Reviewed; Region: rnpA; PRK01903 511995000888 Haemolytic domain; Region: Haemolytic; pfam01809 511995000889 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 511995000890 MgtE intracellular N domain; Region: MgtE_N; smart00924 511995000891 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 511995000892 Divalent cation transporter; Region: MgtE; pfam01769 511995000893 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 511995000894 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 511995000895 active site 511995000896 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 511995000897 Family of unknown function (DUF490); Region: DUF490; pfam04357 511995000898 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 511995000899 active site 511995000900 catalytic residues [active] 511995000901 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 511995000902 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 511995000903 active site 511995000904 substrate binding site [chemical binding]; other site 511995000905 metal binding site [ion binding]; metal-binding site 511995000906 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 511995000907 DHH family; Region: DHH; pfam01368 511995000908 DHHA1 domain; Region: DHHA1; pfam02272 511995000909 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 511995000910 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 511995000911 substrate binding site [chemical binding]; other site 511995000912 hexamer interface [polypeptide binding]; other site 511995000913 metal binding site [ion binding]; metal-binding site 511995000914 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 511995000915 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 511995000916 dimerization interface [polypeptide binding]; other site 511995000917 active site 511995000918 metal binding site [ion binding]; metal-binding site 511995000919 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 511995000920 dsRNA binding site [nucleotide binding]; other site 511995000921 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 511995000922 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 511995000923 dimer interface [polypeptide binding]; other site 511995000924 active site 511995000925 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 511995000926 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 511995000927 TPP-binding site [chemical binding]; other site 511995000928 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 511995000929 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 511995000930 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511995000931 dimer interface [polypeptide binding]; other site 511995000932 PYR/PP interface [polypeptide binding]; other site 511995000933 TPP binding site [chemical binding]; other site 511995000934 substrate binding site [chemical binding]; other site 511995000935 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511995000936 shikimate kinase; Reviewed; Region: aroK; PRK00131 511995000937 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 511995000938 ADP binding site [chemical binding]; other site 511995000939 magnesium binding site [ion binding]; other site 511995000940 putative shikimate binding site; other site 511995000941 D-mannonate oxidoreductase; Provisional; Region: PRK08277 511995000942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511995000943 NAD(P) binding site [chemical binding]; other site 511995000944 active site 511995000945 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 511995000946 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 511995000947 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 511995000948 RNB domain; Region: RNB; pfam00773 511995000949 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 511995000950 RNA binding site [nucleotide binding]; other site 511995000951 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 511995000952 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 511995000953 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 511995000954 protein binding site [polypeptide binding]; other site 511995000955 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 511995000956 protein binding site [polypeptide binding]; other site 511995000957 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 511995000958 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511995000959 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 511995000960 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511995000961 DNA binding residues [nucleotide binding] 511995000962 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 511995000963 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 511995000964 Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190 511995000965 amidophosphoribosyltransferase; Provisional; Region: PRK06781 511995000966 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 511995000967 active site 511995000968 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 511995000969 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 511995000970 active site 511995000971 catalytic site [active] 511995000972 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 511995000973 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 511995000974 Cell division protein FtsA; Region: FtsA; smart00842 511995000975 Cell division protein FtsA; Region: FtsA; pfam14450 511995000976 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 511995000977 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 511995000978 nucleotide binding site [chemical binding]; other site 511995000979 SulA interaction site; other site 511995000980 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 511995000981 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14838 511995000982 catalytic residue [active] 511995000983 putative FPP diphosphate binding site; other site 511995000984 putative FPP binding hydrophobic cleft; other site 511995000985 dimer interface [polypeptide binding]; other site 511995000986 putative IPP diphosphate binding site; other site 511995000987 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 511995000988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511995000989 S-adenosylmethionine binding site [chemical binding]; other site 511995000990 putative hydrolase; Provisional; Region: PRK02113 511995000991 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 511995000992 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 511995000993 Phosphoglycerate kinase; Region: PGK; pfam00162 511995000994 substrate binding site [chemical binding]; other site 511995000995 hinge regions; other site 511995000996 ADP binding site [chemical binding]; other site 511995000997 catalytic site [active] 511995000998 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 511995000999 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511995001000 catalytic residue [active] 511995001001 Domain of unknown function DUF59; Region: DUF59; cl00941 511995001002 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911 511995001003 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 511995001004 DJ-1 family protein; Region: not_thiJ; TIGR01383 511995001005 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 511995001006 conserved cys residue [active] 511995001007 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 511995001008 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 511995001009 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511995001010 ATP binding site [chemical binding]; other site 511995001011 putative Mg++ binding site [ion binding]; other site 511995001012 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511995001013 nucleotide binding region [chemical binding]; other site 511995001014 ATP-binding site [chemical binding]; other site 511995001015 TRCF domain; Region: TRCF; pfam03461 511995001016 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 511995001017 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511995001018 urease subunit alpha; Reviewed; Region: ureC; PRK13207 511995001019 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 511995001020 subunit interactions [polypeptide binding]; other site 511995001021 active site 511995001022 flap region; other site 511995001023 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 511995001024 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 511995001025 alpha-gamma subunit interface [polypeptide binding]; other site 511995001026 beta-gamma subunit interface [polypeptide binding]; other site 511995001027 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 511995001028 gamma-beta subunit interface [polypeptide binding]; other site 511995001029 alpha-beta subunit interface [polypeptide binding]; other site 511995001030 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 511995001031 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 511995001032 Walker A/P-loop; other site 511995001033 ATP binding site [chemical binding]; other site 511995001034 Q-loop/lid; other site 511995001035 ABC transporter signature motif; other site 511995001036 Walker B; other site 511995001037 D-loop; other site 511995001038 H-loop/switch region; other site 511995001039 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 511995001040 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 511995001041 Walker A/P-loop; other site 511995001042 ATP binding site [chemical binding]; other site 511995001043 Q-loop/lid; other site 511995001044 ABC transporter signature motif; other site 511995001045 Walker B; other site 511995001046 D-loop; other site 511995001047 H-loop/switch region; other site 511995001048 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 511995001049 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 511995001050 TM-ABC transporter signature motif; other site 511995001051 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 511995001052 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 511995001053 TM-ABC transporter signature motif; other site 511995001054 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 511995001055 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 511995001056 putative ligand binding site [chemical binding]; other site 511995001057 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 511995001058 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 511995001059 active site 511995001060 HIGH motif; other site 511995001061 dimer interface [polypeptide binding]; other site 511995001062 KMSKS motif; other site 511995001063 glucuronate isomerase; Reviewed; Region: PRK02925 511995001064 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 511995001065 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 511995001066 Phosphate transporter family; Region: PHO4; pfam01384 511995001067 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 511995001068 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 511995001069 Cysteine-rich domain; Region: CCG; pfam02754 511995001070 Cysteine-rich domain; Region: CCG; pfam02754 511995001071 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 511995001072 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 511995001073 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 511995001074 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 511995001075 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 511995001076 enolase; Provisional; Region: eno; PRK00077 511995001077 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 511995001078 dimer interface [polypeptide binding]; other site 511995001079 metal binding site [ion binding]; metal-binding site 511995001080 substrate binding pocket [chemical binding]; other site 511995001081 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 511995001082 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511995001083 active site 511995001084 HIGH motif; other site 511995001085 nucleotide binding site [chemical binding]; other site 511995001086 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 511995001087 active site 511995001088 KMSKS motif; other site 511995001089 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 511995001090 tRNA binding surface [nucleotide binding]; other site 511995001091 anticodon binding site; other site 511995001092 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 511995001093 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 511995001094 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 511995001095 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 511995001096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511995001097 putative substrate translocation pore; other site 511995001098 POT family; Region: PTR2; cl17359 511995001099 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 511995001100 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 511995001101 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 511995001102 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 511995001103 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 511995001104 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511995001105 active site 511995001106 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 511995001107 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 511995001108 homodimer interface [polypeptide binding]; other site 511995001109 substrate-cofactor binding pocket; other site 511995001110 catalytic residue [active] 511995001111 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 511995001112 FAD binding site [chemical binding]; other site 511995001113 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 511995001114 DNA polymerase III subunit delta'; Validated; Region: PRK05564 511995001115 PSP1 C-terminal conserved region; Region: PSP1; cl00770 511995001116 GldH lipoprotein; Region: GldH_lipo; pfam14109 511995001117 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 511995001118 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 511995001119 dimer interface [polypeptide binding]; other site 511995001120 active site 511995001121 metal binding site [ion binding]; metal-binding site 511995001122 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 511995001123 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 511995001124 trmE is a tRNA modification GTPase; Region: trmE; cd04164 511995001125 G1 box; other site 511995001126 GTP/Mg2+ binding site [chemical binding]; other site 511995001127 Switch I region; other site 511995001128 G2 box; other site 511995001129 Switch II region; other site 511995001130 G3 box; other site 511995001131 G4 box; other site 511995001132 G5 box; other site 511995001133 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 511995001134 Ferredoxin [Energy production and conversion]; Region: COG1146 511995001135 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 511995001136 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 511995001137 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 511995001138 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 511995001139 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511995001140 dimer interface [polypeptide binding]; other site 511995001141 PYR/PP interface [polypeptide binding]; other site 511995001142 TPP binding site [chemical binding]; other site 511995001143 substrate binding site [chemical binding]; other site 511995001144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 511995001145 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 511995001146 TPP-binding site [chemical binding]; other site 511995001147 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 511995001148 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 511995001149 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 511995001150 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 511995001151 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 511995001152 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 511995001153 DNA polymerase I; Provisional; Region: PRK05755 511995001154 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 511995001155 active site 511995001156 metal binding site 1 [ion binding]; metal-binding site 511995001157 putative 5' ssDNA interaction site; other site 511995001158 metal binding site 3; metal-binding site 511995001159 metal binding site 2 [ion binding]; metal-binding site 511995001160 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 511995001161 putative DNA binding site [nucleotide binding]; other site 511995001162 putative metal binding site [ion binding]; other site 511995001163 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 511995001164 active site 511995001165 substrate binding site [chemical binding]; other site 511995001166 catalytic site [active] 511995001167 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 511995001168 active site 511995001169 DNA binding site [nucleotide binding] 511995001170 catalytic site [active] 511995001171 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 511995001172 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 511995001173 substrate binding pocket [chemical binding]; other site 511995001174 chain length determination region; other site 511995001175 substrate-Mg2+ binding site; other site 511995001176 catalytic residues [active] 511995001177 aspartate-rich region 1; other site 511995001178 active site lid residues [active] 511995001179 aspartate-rich region 2; other site 511995001180 GTP-binding protein YchF; Reviewed; Region: PRK09601 511995001181 YchF GTPase; Region: YchF; cd01900 511995001182 G1 box; other site 511995001183 GTP/Mg2+ binding site [chemical binding]; other site 511995001184 Switch I region; other site 511995001185 G2 box; other site 511995001186 Switch II region; other site 511995001187 G3 box; other site 511995001188 G4 box; other site 511995001189 G5 box; other site 511995001190 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 511995001191 quinolinate synthetase; Provisional; Region: PRK09375 511995001192 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 511995001193 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 511995001194 Walker A/P-loop; other site 511995001195 ATP binding site [chemical binding]; other site 511995001196 Q-loop/lid; other site 511995001197 ABC transporter signature motif; other site 511995001198 Walker B; other site 511995001199 D-loop; other site 511995001200 H-loop/switch region; other site 511995001201 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 511995001202 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 511995001203 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 511995001204 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 511995001205 CPxP motif; other site 511995001206 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 511995001207 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 511995001208 ATP binding site [chemical binding]; other site 511995001209 substrate interface [chemical binding]; other site 511995001210 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 511995001211 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 511995001212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511995001213 dimer interface [polypeptide binding]; other site 511995001214 conserved gate region; other site 511995001215 putative PBP binding loops; other site 511995001216 ABC-ATPase subunit interface; other site 511995001217 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 511995001218 dimer interface [polypeptide binding]; other site 511995001219 conserved gate region; other site 511995001220 putative PBP binding loops; other site 511995001221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 511995001222 ABC-ATPase subunit interface; other site 511995001223 porphobilinogen deaminase; Provisional; Region: PRK01066 511995001224 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 511995001225 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 511995001226 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 511995001227 active site 511995001228 SAM binding site [chemical binding]; other site 511995001229 homodimer interface [polypeptide binding]; other site 511995001230 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 511995001231 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 511995001232 active site 511995001233 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 511995001234 dimer interface [polypeptide binding]; other site 511995001235 active site 511995001236 Schiff base residues; other site 511995001237 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 511995001238 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 511995001239 Active Sites [active] 511995001240 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 511995001241 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 511995001242 CysD dimerization site [polypeptide binding]; other site 511995001243 G1 box; other site 511995001244 putative GEF interaction site [polypeptide binding]; other site 511995001245 GTP/Mg2+ binding site [chemical binding]; other site 511995001246 Switch I region; other site 511995001247 G2 box; other site 511995001248 G3 box; other site 511995001249 Switch II region; other site 511995001250 G4 box; other site 511995001251 G5 box; other site 511995001252 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 511995001253 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 511995001254 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 511995001255 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 511995001256 Active Sites [active] 511995001257 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 511995001258 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 511995001259 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 511995001260 23S rRNA interface [nucleotide binding]; other site 511995001261 L3 interface [polypeptide binding]; other site 511995001262 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 511995001263 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 511995001264 rRNA interaction site [nucleotide binding]; other site 511995001265 S8 interaction site; other site 511995001266 putative laminin-1 binding site; other site 511995001267 elongation factor Ts; Provisional; Region: tsf; PRK09377 511995001268 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 511995001269 Elongation factor TS; Region: EF_TS; pfam00889 511995001270 Elongation factor TS; Region: EF_TS; pfam00889 511995001271 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 511995001272 oligomerisation interface [polypeptide binding]; other site 511995001273 mobile loop; other site 511995001274 roof hairpin; other site 511995001275 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 511995001276 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 511995001277 ring oligomerisation interface [polypeptide binding]; other site 511995001278 ATP/Mg binding site [chemical binding]; other site 511995001279 stacking interactions; other site 511995001280 hinge regions; other site 511995001281 elongation factor P; Validated; Region: PRK00529 511995001282 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 511995001283 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 511995001284 RNA binding site [nucleotide binding]; other site 511995001285 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 511995001286 RNA binding site [nucleotide binding]; other site 511995001287 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 511995001288 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 511995001289 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 511995001290 NADP binding site [chemical binding]; other site 511995001291 active site 511995001292 putative substrate binding site [chemical binding]; other site 511995001293 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 511995001294 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 511995001295 active site 511995001296 substrate binding site [chemical binding]; other site 511995001297 cosubstrate binding site; other site 511995001298 catalytic site [active] 511995001299 Ribosome-binding factor A; Region: RBFA; pfam02033 511995001300 putative recombination protein RecB; Provisional; Region: PRK13909 511995001301 Family description; Region: UvrD_C_2; pfam13538 511995001302 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 511995001303 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 511995001304 chaperone protein DnaJ; Provisional; Region: PRK14289 511995001305 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 511995001306 HSP70 interaction site [polypeptide binding]; other site 511995001307 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 511995001308 substrate binding site [polypeptide binding]; other site 511995001309 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 511995001310 Zn binding sites [ion binding]; other site 511995001311 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 511995001312 dimer interface [polypeptide binding]; other site 511995001313 GrpE; Region: GrpE; pfam01025 511995001314 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 511995001315 dimer interface [polypeptide binding]; other site 511995001316 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 511995001317 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 511995001318 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 511995001319 active site 511995001320 HIGH motif; other site 511995001321 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 511995001322 KMSKS motif; other site 511995001323 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 511995001324 tRNA binding surface [nucleotide binding]; other site 511995001325 anticodon binding site; other site 511995001326 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 511995001327 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 511995001328 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 511995001329 predicted active site [active] 511995001330 catalytic triad [active] 511995001331 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 511995001332 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 511995001333 active site 511995001334 multimer interface [polypeptide binding]; other site 511995001335 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 511995001336 malate dehydrogenase; Reviewed; Region: PRK06223 511995001337 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 511995001338 NAD(P) binding site [chemical binding]; other site 511995001339 dimer interface [polypeptide binding]; other site 511995001340 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511995001341 substrate binding site [chemical binding]; other site 511995001342 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 511995001343 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 511995001344 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 511995001345 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511995001346 motif II; other site 511995001347 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 511995001348 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 511995001349 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 511995001350 membrane ATPase/protein kinase; Provisional; Region: PRK09435 511995001351 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 511995001352 Walker A; other site 511995001353 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 511995001354 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 511995001355 active site 511995001356 dimer interface [polypeptide binding]; other site 511995001357 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 511995001358 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 511995001359 active site 511995001360 FMN binding site [chemical binding]; other site 511995001361 substrate binding site [chemical binding]; other site 511995001362 3Fe-4S cluster binding site [ion binding]; other site 511995001363 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 511995001364 domain interface; other site 511995001365 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 511995001366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511995001367 asparagine synthetase B; Provisional; Region: asnB; PRK09431 511995001368 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 511995001369 active site 511995001370 dimer interface [polypeptide binding]; other site 511995001371 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 511995001372 Ligand Binding Site [chemical binding]; other site 511995001373 Molecular Tunnel; other site 511995001374 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 511995001375 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 511995001376 TrkA-C domain; Region: TrkA_C; pfam02080 511995001377 TrkA-C domain; Region: TrkA_C; pfam02080 511995001378 excinuclease ABC subunit B; Provisional; Region: PRK05298 511995001379 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511995001380 ATP binding site [chemical binding]; other site 511995001381 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511995001382 nucleotide binding region [chemical binding]; other site 511995001383 ATP-binding site [chemical binding]; other site 511995001384 Ultra-violet resistance protein B; Region: UvrB; pfam12344 511995001385 UvrB/uvrC motif; Region: UVR; pfam02151 511995001386 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 511995001387 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 511995001388 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14466 511995001389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511995001390 FeS/SAM binding site; other site 511995001391 SurA N-terminal domain; Region: SurA_N_3; cl07813 511995001392 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 511995001393 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 511995001394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511995001395 S-adenosylmethionine binding site [chemical binding]; other site 511995001396 Dehydroquinase class II; Region: DHquinase_II; pfam01220 511995001397 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 511995001398 trimer interface [polypeptide binding]; other site 511995001399 active site 511995001400 dimer interface [polypeptide binding]; other site 511995001401 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 511995001402 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 511995001403 active site 511995001404 DNA binding site [nucleotide binding] 511995001405 Int/Topo IB signature motif; other site 511995001406 acetylornithine aminotransferase; Provisional; Region: PRK02627 511995001407 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511995001408 inhibitor-cofactor binding pocket; inhibition site 511995001409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511995001410 catalytic residue [active] 511995001411 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 511995001412 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 511995001413 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 511995001414 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511995001415 nucleotide binding site [chemical binding]; other site 511995001416 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 511995001417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511995001418 Walker A motif; other site 511995001419 ATP binding site [chemical binding]; other site 511995001420 Walker B motif; other site 511995001421 arginine finger; other site 511995001422 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 511995001423 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 511995001424 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 511995001425 putative transporter; Validated; Region: PRK03818 511995001426 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 511995001427 TrkA-C domain; Region: TrkA_C; pfam02080 511995001428 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 511995001429 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 511995001430 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 511995001431 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511995001432 minor groove reading motif; other site 511995001433 helix-hairpin-helix signature motif; other site 511995001434 substrate binding pocket [chemical binding]; other site 511995001435 active site 511995001436 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 511995001437 DNA binding and oxoG recognition site [nucleotide binding] 511995001438 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 511995001439 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 511995001440 dimer interface [polypeptide binding]; other site 511995001441 ssDNA binding site [nucleotide binding]; other site 511995001442 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511995001443 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 511995001444 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 511995001445 Ligand Binding Site [chemical binding]; other site 511995001446 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 511995001447 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 511995001448 Substrate binding site; other site 511995001449 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 511995001450 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511995001451 active site 511995001452 HIGH motif; other site 511995001453 nucleotide binding site [chemical binding]; other site 511995001454 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 511995001455 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 511995001456 active site 511995001457 KMSKS motif; other site 511995001458 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 511995001459 tRNA binding surface [nucleotide binding]; other site 511995001460 anticodon binding site; other site 511995001461 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 511995001462 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 511995001463 IHF dimer interface [polypeptide binding]; other site 511995001464 IHF - DNA interface [nucleotide binding]; other site 511995001465 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 511995001466 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 511995001467 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 511995001468 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 511995001469 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 511995001470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511995001471 nucleotide binding region [chemical binding]; other site 511995001472 ATP-binding site [chemical binding]; other site 511995001473 SEC-C motif; Region: SEC-C; pfam02810 511995001474 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 511995001475 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 511995001476 homodimer interface [polypeptide binding]; other site 511995001477 oligonucleotide binding site [chemical binding]; other site 511995001478 pyruvate phosphate dikinase; Provisional; Region: PRK09279 511995001479 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 511995001480 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 511995001481 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 511995001482 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 511995001483 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 511995001484 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511995001485 active site 511995001486 HIGH motif; other site 511995001487 nucleotide binding site [chemical binding]; other site 511995001488 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 511995001489 KMSKS motif; other site 511995001490 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 511995001491 Septum formation initiator; Region: DivIC; cl17659 511995001492 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 511995001493 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 511995001494 FMN binding site [chemical binding]; other site 511995001495 substrate binding site [chemical binding]; other site 511995001496 putative catalytic residue [active] 511995001497 L-aspartate oxidase; Provisional; Region: PRK09077 511995001498 L-aspartate oxidase; Provisional; Region: PRK06175 511995001499 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 511995001500 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 511995001501 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 511995001502 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 511995001503 YceG-like family; Region: YceG; pfam02618 511995001504 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 511995001505 dimerization interface [polypeptide binding]; other site 511995001506 GTPase Era; Reviewed; Region: era; PRK00089 511995001507 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 511995001508 G1 box; other site 511995001509 GTP/Mg2+ binding site [chemical binding]; other site 511995001510 Switch I region; other site 511995001511 G2 box; other site 511995001512 Switch II region; other site 511995001513 G3 box; other site 511995001514 G4 box; other site 511995001515 G5 box; other site 511995001516 KH domain; Region: KH_2; pfam07650 511995001517 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 511995001518 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 511995001519 argininosuccinate synthase; Provisional; Region: PRK13820 511995001520 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 511995001521 Ligand Binding Site [chemical binding]; other site 511995001522 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 511995001523 Coenzyme A binding pocket [chemical binding]; other site 511995001524 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511995001525 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 511995001526 catalytic residues [active] 511995001527 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 511995001528 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 511995001529 active site 511995001530 PHP Thumb interface [polypeptide binding]; other site 511995001531 metal binding site [ion binding]; metal-binding site 511995001532 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 511995001533 generic binding surface II; other site 511995001534 generic binding surface I; other site 511995001535 Predicted permeases [General function prediction only]; Region: COG0679 511995001536 WbqC-like protein family; Region: WbqC; pfam08889 511995001537 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 511995001538 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 511995001539 Catalytic site [active] 511995001540 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 511995001541 dihydrodipicolinate reductase; Provisional; Region: PRK00048 511995001542 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 511995001543 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 511995001544 aspartate aminotransferase; Provisional; Region: PRK07568 511995001545 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511995001546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511995001547 homodimer interface [polypeptide binding]; other site 511995001548 catalytic residue [active] 511995001549 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 511995001550 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 511995001551 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 511995001552 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 511995001553 AIR carboxylase; Region: AIRC; pfam00731 511995001554 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 511995001555 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 511995001556 C-terminal peptidase (prc); Region: prc; TIGR00225 511995001557 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 511995001558 protein binding site [polypeptide binding]; other site 511995001559 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 511995001560 Catalytic dyad [active] 511995001561 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 511995001562 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 511995001563 Ligand binding site; other site 511995001564 Putative Catalytic site; other site 511995001565 DXD motif; other site 511995001566 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 511995001567 16S/18S rRNA binding site [nucleotide binding]; other site 511995001568 S13e-L30e interaction site [polypeptide binding]; other site 511995001569 25S rRNA binding site [nucleotide binding]; other site 511995001570 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 511995001571 core domain interface [polypeptide binding]; other site 511995001572 delta subunit interface [polypeptide binding]; other site 511995001573 epsilon subunit interface [polypeptide binding]; other site 511995001574 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 511995001575 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 511995001576 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 511995001577 beta subunit interaction interface [polypeptide binding]; other site 511995001578 Walker A motif; other site 511995001579 ATP binding site [chemical binding]; other site 511995001580 Walker B motif; other site 511995001581 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 511995001582 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 511995001583 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 511995001584 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 511995001585 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 511995001586 ATP synthase subunit C; Region: ATP-synt_C; cl00466 511995001587 ATP synthase A chain; Region: ATP-synt_A; cl00413 511995001588 RIP metalloprotease RseP; Region: TIGR00054 511995001589 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 511995001590 active site 511995001591 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 511995001592 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 511995001593 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 511995001594 putative substrate binding region [chemical binding]; other site 511995001595 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 511995001596 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 511995001597 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 511995001598 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 511995001599 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 511995001600 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 511995001601 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 511995001602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511995001603 Walker A/P-loop; other site 511995001604 ATP binding site [chemical binding]; other site 511995001605 Q-loop/lid; other site 511995001606 ABC transporter signature motif; other site 511995001607 Walker B; other site 511995001608 D-loop; other site 511995001609 H-loop/switch region; other site 511995001610 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 511995001611 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 511995001612 trimer interface [polypeptide binding]; other site 511995001613 putative metal binding site [ion binding]; other site 511995001614 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 511995001615 ligand binding site [chemical binding]; other site 511995001616 active site 511995001617 UGI interface [polypeptide binding]; other site 511995001618 catalytic site [active] 511995001619 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 511995001620 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511995001621 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 511995001622 RecX family; Region: RecX; pfam02631 511995001623 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 511995001624 putative catalytic site [active] 511995001625 putative metal binding site [ion binding]; other site 511995001626 putative phosphate binding site [ion binding]; other site 511995001627 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 511995001628 acyl carrier protein; Provisional; Region: acpP; PRK00982 511995001629 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 511995001630 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 511995001631 metal binding site [ion binding]; metal-binding site 511995001632 dimer interface [polypeptide binding]; other site 511995001633 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511995001634 Radical SAM superfamily; Region: Radical_SAM; pfam04055 511995001635 FeS/SAM binding site; other site 511995001636 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 511995001637 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 511995001638 MutS domain I; Region: MutS_I; pfam01624 511995001639 MutS domain II; Region: MutS_II; pfam05188 511995001640 MutS domain III; Region: MutS_III; pfam05192 511995001641 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 511995001642 Walker A/P-loop; other site 511995001643 ATP binding site [chemical binding]; other site 511995001644 Q-loop/lid; other site 511995001645 ABC transporter signature motif; other site 511995001646 Walker B; other site 511995001647 D-loop; other site 511995001648 H-loop/switch region; other site 511995001649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511995001650 active site 511995001651 motif I; other site 511995001652 motif II; other site 511995001653 Mechanosensitive ion channel; Region: MS_channel; pfam00924 511995001654 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 511995001655 hypothetical protein; Provisional; Region: PRK13665 511995001656 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 511995001657 Glutamine amidotransferase class-I; Region: GATase; pfam00117 511995001658 glutamine binding [chemical binding]; other site 511995001659 catalytic triad [active] 511995001660 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 511995001661 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 511995001662 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 511995001663 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 511995001664 active site 511995001665 ribulose/triose binding site [chemical binding]; other site 511995001666 phosphate binding site [ion binding]; other site 511995001667 substrate (anthranilate) binding pocket [chemical binding]; other site 511995001668 product (indole) binding pocket [chemical binding]; other site 511995001669 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 511995001670 active site 511995001671 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 511995001672 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 511995001673 substrate binding site [chemical binding]; other site 511995001674 active site 511995001675 catalytic residues [active] 511995001676 heterodimer interface [polypeptide binding]; other site 511995001677 replicative DNA helicase; Region: DnaB; TIGR00665 511995001678 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 511995001679 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 511995001680 Walker A motif; other site 511995001681 ATP binding site [chemical binding]; other site 511995001682 Walker B motif; other site 511995001683 DNA binding loops [nucleotide binding] 511995001684 NAD-dependent deacetylase; Provisional; Region: PRK00481 511995001685 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 511995001686 NAD+ binding site [chemical binding]; other site 511995001687 substrate binding site [chemical binding]; other site 511995001688 Zn binding site [ion binding]; other site 511995001689 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 511995001690 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 511995001691 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 511995001692 substrate binding pocket [chemical binding]; other site 511995001693 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 511995001694 B12 binding site [chemical binding]; other site 511995001695 cobalt ligand [ion binding]; other site 511995001696 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 511995001697 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 511995001698 RuvA N terminal domain; Region: RuvA_N; pfam01330 511995001699 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 511995001700 active site 511995001701 dimer interface [polypeptide binding]; other site 511995001702 metal binding site [ion binding]; metal-binding site 511995001703 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 511995001704 nucleotide binding site/active site [active] 511995001705 HIT family signature motif; other site 511995001706 catalytic residue [active] 511995001707 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 511995001708 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 511995001709 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 511995001710 hypothetical protein; Provisional; Region: PRK11820 511995001711 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 511995001712 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 511995001713 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 511995001714 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 511995001715 catalytic site [active] 511995001716 G-X2-G-X-G-K; other site 511995001717 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 511995001718 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 511995001719 active site 511995001720 (T/H)XGH motif; other site 511995001721 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 511995001722 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 511995001723 GDP-binding site [chemical binding]; other site 511995001724 ACT binding site; other site 511995001725 IMP binding site; other site 511995001726 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 511995001727 Bifunctional nuclease; Region: DNase-RNase; pfam02577 511995001728 UvrB/uvrC motif; Region: UVR; pfam02151 511995001729 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 511995001730 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 511995001731 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 511995001732 TPP-binding site [chemical binding]; other site 511995001733 dimer interface [polypeptide binding]; other site 511995001734 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 511995001735 PYR/PP interface [polypeptide binding]; other site 511995001736 dimer interface [polypeptide binding]; other site 511995001737 TPP binding site [chemical binding]; other site 511995001738 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511995001739 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 511995001740 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 511995001741 Walker A/P-loop; other site 511995001742 ATP binding site [chemical binding]; other site 511995001743 Q-loop/lid; other site 511995001744 ABC transporter signature motif; other site 511995001745 Walker B; other site 511995001746 D-loop; other site 511995001747 H-loop/switch region; other site 511995001748 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 511995001749 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 511995001750 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 511995001751 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 511995001752 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 511995001753 C-terminal peptidase (prc); Region: prc; TIGR00225 511995001754 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 511995001755 protein binding site [polypeptide binding]; other site 511995001756 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 511995001757 Catalytic dyad [active] 511995001758 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 511995001759 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511995001760 Zn2+ binding site [ion binding]; other site 511995001761 Mg2+ binding site [ion binding]; other site 511995001762 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 511995001763 synthetase active site [active] 511995001764 NTP binding site [chemical binding]; other site 511995001765 metal binding site [ion binding]; metal-binding site 511995001766 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 511995001767 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 511995001768 Protein of unknown function (DUF721); Region: DUF721; pfam05258 511995001769 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 511995001770 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 511995001771 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 511995001772 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 511995001773 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 511995001774 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 511995001775 active site 511995001776 catalytic site [active] 511995001777 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 511995001778 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 511995001779 NADH dehydrogenase subunit B; Provisional; Region: PRK14816 511995001780 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 511995001781 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 511995001782 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 511995001783 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 511995001784 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 511995001785 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 511995001786 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 511995001787 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 511995001788 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 511995001789 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 511995001790 active site 511995001791 HIGH motif; other site 511995001792 dimer interface [polypeptide binding]; other site 511995001793 KMSKS motif; other site 511995001794 S4 RNA-binding domain; Region: S4; smart00363 511995001795 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 511995001796 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 511995001797 active site 511995001798 DNA binding site [nucleotide binding] 511995001799 Int/Topo IB signature motif; other site 511995001800 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 511995001801 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 511995001802 active site 511995001803 metal binding site [ion binding]; metal-binding site 511995001804 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 511995001805 catalytic center binding site [active] 511995001806 ATP binding site [chemical binding]; other site 511995001807 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 511995001808 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 511995001809 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 511995001810 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 511995001811 RNA binding site [nucleotide binding]; other site 511995001812 active site 511995001813 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 511995001814 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 511995001815 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 511995001816 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511995001817 FeS/SAM binding site; other site 511995001818 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 511995001819 putative active site [active] 511995001820 putative metal binding residues [ion binding]; other site 511995001821 signature motif; other site 511995001822 putative dimer interface [polypeptide binding]; other site 511995001823 putative phosphate binding site [ion binding]; other site 511995001824 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 511995001825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511995001826 dimer interface [polypeptide binding]; other site 511995001827 conserved gate region; other site 511995001828 putative PBP binding loops; other site 511995001829 ABC-ATPase subunit interface; other site 511995001830 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 511995001831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511995001832 Walker A/P-loop; other site 511995001833 ATP binding site [chemical binding]; other site 511995001834 Q-loop/lid; other site 511995001835 ABC transporter signature motif; other site 511995001836 Walker B; other site 511995001837 D-loop; other site 511995001838 H-loop/switch region; other site 511995001839 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 511995001840 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 511995001841 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 511995001842 transcription antitermination factor NusB; Region: nusB; TIGR01951 511995001843 aspartate aminotransferase; Provisional; Region: PRK05764 511995001844 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511995001845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511995001846 homodimer interface [polypeptide binding]; other site 511995001847 catalytic residue [active] 511995001848 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 511995001849 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511995001850 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511995001851 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 511995001852 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 511995001853 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 511995001854 DNA primase, catalytic core; Region: dnaG; TIGR01391 511995001855 CHC2 zinc finger; Region: zf-CHC2; pfam01807 511995001856 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 511995001857 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 511995001858 active site 511995001859 metal binding site [ion binding]; metal-binding site 511995001860 interdomain interaction site; other site 511995001861 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 511995001862 A new structural DNA glycosylase; Region: AlkD_like; cd06561 511995001863 active site 511995001864 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 511995001865 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 511995001866 Starch binding domain; Region: CBM_2; smart01065 511995001867 starch-binding site 2 [chemical binding]; other site 511995001868 starch-binding site 1 [chemical binding]; other site 511995001869 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 511995001870 starch-binding site 2 [chemical binding]; other site 511995001871 starch-binding site 1 [chemical binding]; other site 511995001872 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 511995001873 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 511995001874 purine nucleoside phosphorylase; Provisional; Region: PRK08202 511995001875 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 511995001876 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 511995001877 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 511995001878 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511995001879 dimer interface [polypeptide binding]; other site 511995001880 PYR/PP interface [polypeptide binding]; other site 511995001881 TPP binding site [chemical binding]; other site 511995001882 substrate binding site [chemical binding]; other site 511995001883 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 511995001884 Domain of unknown function; Region: EKR; smart00890 511995001885 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 511995001886 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 511995001887 TPP-binding site [chemical binding]; other site 511995001888 dimer interface [polypeptide binding]; other site 511995001889 Chromate transporter; Region: Chromate_transp; pfam02417 511995001890 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 511995001891 putative acyl-acceptor binding pocket; other site 511995001892 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 511995001893 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 511995001894 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 511995001895 putative Iron-sulfur protein interface [polypeptide binding]; other site 511995001896 proximal heme binding site [chemical binding]; other site 511995001897 distal heme binding site [chemical binding]; other site 511995001898 putative dimer interface [polypeptide binding]; other site 511995001899 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 511995001900 L-aspartate oxidase; Provisional; Region: PRK06175 511995001901 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 511995001902 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 511995001903 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 511995001904 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 511995001905 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 511995001906 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 511995001907 metal binding site [ion binding]; metal-binding site 511995001908 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 511995001909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511995001910 Walker A/P-loop; other site 511995001911 ATP binding site [chemical binding]; other site 511995001912 Q-loop/lid; other site 511995001913 ABC transporter signature motif; other site 511995001914 Walker B; other site 511995001915 D-loop; other site 511995001916 H-loop/switch region; other site 511995001917 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 511995001918 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 511995001919 active site 511995001920 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511995001921 substrate binding site [chemical binding]; other site 511995001922 catalytic residues [active] 511995001923 dimer interface [polypeptide binding]; other site 511995001924 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 511995001925 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 511995001926 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 511995001927 substrate binding site; other site 511995001928 tetramer interface; other site 511995001929 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 511995001930 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 511995001931 NAD binding site [chemical binding]; other site 511995001932 substrate binding site [chemical binding]; other site 511995001933 homodimer interface [polypeptide binding]; other site 511995001934 active site 511995001935 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 511995001936 RimM N-terminal domain; Region: RimM; pfam01782 511995001937 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 511995001938 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 511995001939 hinge; other site 511995001940 active site 511995001941 GTPase CgtA; Reviewed; Region: obgE; PRK12299 511995001942 GTP1/OBG; Region: GTP1_OBG; pfam01018 511995001943 Obg GTPase; Region: Obg; cd01898 511995001944 G1 box; other site 511995001945 GTP/Mg2+ binding site [chemical binding]; other site 511995001946 Switch I region; other site 511995001947 G2 box; other site 511995001948 G3 box; other site 511995001949 Switch II region; other site 511995001950 G4 box; other site 511995001951 G5 box; other site 511995001952 adenylate kinase; Reviewed; Region: adk; PRK00279 511995001953 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 511995001954 AMP-binding site [chemical binding]; other site 511995001955 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 511995001956 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511995001957 active site 511995001958 fumarate hydratase; Provisional; Region: PRK15389 511995001959 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 511995001960 Fumarase C-terminus; Region: Fumerase_C; pfam05683 511995001961 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 511995001962 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 511995001963 RNase E interface [polypeptide binding]; other site 511995001964 trimer interface [polypeptide binding]; other site 511995001965 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 511995001966 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 511995001967 RNase E interface [polypeptide binding]; other site 511995001968 trimer interface [polypeptide binding]; other site 511995001969 active site 511995001970 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 511995001971 nucleic acid binding region [nucleotide binding]; other site 511995001972 G-X-X-G motif; other site 511995001973 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 511995001974 RNA binding site [nucleotide binding]; other site 511995001975 domain interface; other site 511995001976 Uncharacterized conserved protein [Function unknown]; Region: COG4198 511995001977 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 511995001978 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511995001979 active site 511995001980 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 511995001981 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 511995001982 homodimer interface [polypeptide binding]; other site 511995001983 substrate-cofactor binding pocket; other site 511995001984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511995001985 catalytic residue [active] 511995001986 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 511995001987 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 511995001988 active site 511995001989 catalytic residues [active] 511995001990 metal binding site [ion binding]; metal-binding site 511995001991 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 511995001992 Nif-specific regulatory protein; Region: nifA; TIGR01817 511995001993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511995001994 Walker A motif; other site 511995001995 ATP binding site [chemical binding]; other site 511995001996 Walker B motif; other site 511995001997 arginine finger; other site 511995001998 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 511995001999 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 511995002000 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511995002001 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511995002002 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 511995002003 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 511995002004 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 511995002005 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511995002006 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511995002007 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 511995002008 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 511995002009 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 511995002010 RNA binding site [nucleotide binding]; other site 511995002011 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 511995002012 RNA binding site [nucleotide binding]; other site 511995002013 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 511995002014 RNA binding site [nucleotide binding]; other site 511995002015 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 511995002016 RNA binding site [nucleotide binding]; other site 511995002017 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 511995002018 RNA binding site [nucleotide binding]; other site 511995002019 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 511995002020 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 511995002021 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 511995002022 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 511995002023 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 511995002024 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511995002025 FeS/SAM binding site; other site 511995002026 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 511995002027 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511995002028 FeS/SAM binding site; other site 511995002029 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 511995002030 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 511995002031 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 511995002032 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511995002033 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 511995002034 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 511995002035 FAD binding domain; Region: FAD_binding_4; pfam01565 511995002036 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 511995002037 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 511995002038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511995002039 S-adenosylmethionine binding site [chemical binding]; other site 511995002040 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 511995002041 active sites [active] 511995002042 Lyase; Region: Lyase_1; pfam00206 511995002043 tetramer interface [polypeptide binding]; other site 511995002044 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511995002045 active site 511995002046 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 511995002047 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 511995002048 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511995002049 FeS/SAM binding site; other site 511995002050 TRAM domain; Region: TRAM; pfam01938 511995002051 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 511995002052 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 511995002053 substrate binding pocket [chemical binding]; other site 511995002054 chain length determination region; other site 511995002055 substrate-Mg2+ binding site; other site 511995002056 catalytic residues [active] 511995002057 aspartate-rich region 1; other site 511995002058 active site lid residues [active] 511995002059 aspartate-rich region 2; other site 511995002060 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 511995002061 active site 511995002062 recombination protein RecR; Reviewed; Region: recR; PRK00076 511995002063 RecR protein; Region: RecR; pfam02132 511995002064 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 511995002065 putative active site [active] 511995002066 putative metal-binding site [ion binding]; other site 511995002067 tetramer interface [polypeptide binding]; other site 511995002068 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 511995002069 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 511995002070 NAD(P) binding site [chemical binding]; other site 511995002071 homotetramer interface [polypeptide binding]; other site 511995002072 homodimer interface [polypeptide binding]; other site 511995002073 active site 511995002074 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 511995002075 Malic enzyme, N-terminal domain; Region: malic; pfam00390 511995002076 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 511995002077 putative NAD(P) binding site [chemical binding]; other site 511995002078 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 511995002079 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 511995002080 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 511995002081 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 511995002082 catalytic site [active] 511995002083 subunit interface [polypeptide binding]; other site 511995002084 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 511995002085 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511995002086 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 511995002087 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 511995002088 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511995002089 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511995002090 Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423 511995002091 probable substrate binding site [chemical binding]; other site 511995002092 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 511995002093 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511995002094 Zn2+ binding site [ion binding]; other site 511995002095 Mg2+ binding site [ion binding]; other site 511995002096 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 511995002097 active site 511995002098 dimer interface [polypeptide binding]; other site 511995002099 peptide chain release factor 1; Validated; Region: prfA; PRK00591 511995002100 This domain is found in peptide chain release factors; Region: PCRF; smart00937 511995002101 RF-1 domain; Region: RF-1; pfam00472 511995002102 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511995002103 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 511995002104 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 511995002105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 511995002106 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 511995002107 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 511995002108 glutaminase active site [active] 511995002109 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 511995002110 dimer interface [polypeptide binding]; other site 511995002111 active site 511995002112 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 511995002113 dimer interface [polypeptide binding]; other site 511995002114 active site 511995002115 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 511995002116 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 511995002117 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 511995002118 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 511995002119 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511995002120 N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795 511995002121 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 511995002122 putative active site [active] 511995002123 catalytic site [active] 511995002124 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 511995002125 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 511995002126 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 511995002127 folate binding site [chemical binding]; other site 511995002128 NADP+ binding site [chemical binding]; other site 511995002129 thymidylate synthase; Reviewed; Region: thyA; PRK01827 511995002130 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 511995002131 dimerization interface [polypeptide binding]; other site 511995002132 active site 511995002133 This domain is found in peptide chain release factors; Region: PCRF; smart00937 511995002134 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 511995002135 RF-1 domain; Region: RF-1; pfam00472 511995002136 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 511995002137 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 511995002138 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 511995002139 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 511995002140 nucleotide binding site [chemical binding]; other site 511995002141 xylose isomerase; Provisional; Region: PRK05474 511995002142 xylose isomerase; Region: xylose_isom_A; TIGR02630 511995002143 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 511995002144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511995002145 putative substrate translocation pore; other site 511995002146 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 511995002147 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 511995002148 nucleotide binding site [chemical binding]; other site 511995002149 NEF interaction site [polypeptide binding]; other site 511995002150 SBD interface [polypeptide binding]; other site 511995002151 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 511995002152 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 511995002153 motif 1; other site 511995002154 active site 511995002155 motif 2; other site 511995002156 motif 3; other site 511995002157 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 511995002158 DHHA1 domain; Region: DHHA1; pfam02272 511995002159 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 511995002160 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511995002161 DNA binding residues [nucleotide binding] 511995002162 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 511995002163 dimer interface [polypeptide binding]; other site 511995002164 pyridoxal binding site [chemical binding]; other site 511995002165 ATP binding site [chemical binding]; other site 511995002166 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511995002167 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 511995002168 dimerization interface [polypeptide binding]; other site 511995002169 ATP binding site [chemical binding]; other site 511995002170 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 511995002171 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 511995002172 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 511995002173 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 511995002174 UDP-glucose 4-epimerase; Region: PLN02240 511995002175 NAD binding site [chemical binding]; other site 511995002176 homodimer interface [polypeptide binding]; other site 511995002177 active site 511995002178 substrate binding site [chemical binding]; other site 511995002179 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 511995002180 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 511995002181 purine monophosphate binding site [chemical binding]; other site 511995002182 dimer interface [polypeptide binding]; other site 511995002183 putative catalytic residues [active] 511995002184 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 511995002185 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 511995002186 rod shape-determining protein MreB; Provisional; Region: PRK13927 511995002187 MreB and similar proteins; Region: MreB_like; cd10225 511995002188 nucleotide binding site [chemical binding]; other site 511995002189 Mg binding site [ion binding]; other site 511995002190 putative protofilament interaction site [polypeptide binding]; other site 511995002191 RodZ interaction site [polypeptide binding]; other site 511995002192 rod shape-determining protein MreC; Provisional; Region: PRK13922 511995002193 rod shape-determining protein MreC; Region: MreC; pfam04085 511995002194 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 511995002195 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 511995002196 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 511995002197 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 511995002198 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 511995002199 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 511995002200 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 511995002201 dimer interface [polypeptide binding]; other site 511995002202 substrate binding site [chemical binding]; other site 511995002203 metal binding site [ion binding]; metal-binding site 511995002204 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 511995002205 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 511995002206 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 511995002207 Lamin Tail Domain; Region: LTD; pfam00932 511995002208 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 511995002209 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 511995002210 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 511995002211 carboxyltransferase (CT) interaction site; other site 511995002212 biotinylation site [posttranslational modification]; other site 511995002213 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 511995002214 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 511995002215 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 511995002216 UbiA prenyltransferase family; Region: UbiA; pfam01040 511995002217 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 511995002218 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 511995002219 seryl-tRNA synthetase; Provisional; Region: PRK05431 511995002220 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 511995002221 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 511995002222 motif 1; other site 511995002223 dimer interface [polypeptide binding]; other site 511995002224 active site 511995002225 motif 2; other site 511995002226 motif 3; other site 511995002227 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 511995002228 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 511995002229 ligand binding site [chemical binding]; other site 511995002230 flexible hinge region; other site 511995002231 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 511995002232 putative switch regulator; other site 511995002233 non-specific DNA interactions [nucleotide binding]; other site 511995002234 DNA binding site [nucleotide binding] 511995002235 sequence specific DNA binding site [nucleotide binding]; other site 511995002236 putative cAMP binding site [chemical binding]; other site 511995002237 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 511995002238 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 511995002239 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 511995002240 GIY-YIG motif/motif A; other site 511995002241 active site 511995002242 catalytic site [active] 511995002243 putative DNA binding site [nucleotide binding]; other site 511995002244 metal binding site [ion binding]; metal-binding site 511995002245 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 511995002246 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 511995002247 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 511995002248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511995002249 Walker A motif; other site 511995002250 ATP binding site [chemical binding]; other site 511995002251 Walker B motif; other site 511995002252 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 511995002253 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 511995002254 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 511995002255 oligomer interface [polypeptide binding]; other site 511995002256 active site residues [active] 511995002257 trigger factor; Region: tig; TIGR00115 511995002258 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 511995002259 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 511995002260 Nucleotide-binding sites [chemical binding]; other site 511995002261 Walker A motif; other site 511995002262 Switch I region of nucleotide binding site; other site 511995002263 Fe4S4 binding sites [ion binding]; other site 511995002264 Switch II region of nucleotide binding site; other site 511995002265 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 511995002266 Nitrogen regulatory protein P-II; Region: P-II; smart00938 511995002267 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 511995002268 Nitrogen regulatory protein P-II; Region: P-II; smart00938 511995002269 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 511995002270 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 511995002271 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 511995002272 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 511995002273 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 511995002274 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 511995002275 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 511995002276 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 511995002277 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 511995002278 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511995002279 FeS/SAM binding site; other site 511995002280 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 511995002281 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 511995002282 dimer interface [polypeptide binding]; other site 511995002283 [2Fe-2S] cluster binding site [ion binding]; other site 511995002284 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 511995002285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511995002286 binding surface 511995002287 TPR motif; other site 511995002288 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 511995002289 intersubunit interface [polypeptide binding]; other site 511995002290 active site 511995002291 catalytic residue [active] 511995002292 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 511995002293 active site 511995002294 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 511995002295 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 511995002296 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 511995002297 active site 511995002298 substrate binding site [chemical binding]; other site 511995002299 coenzyme B12 binding site [chemical binding]; other site 511995002300 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 511995002301 B12 binding site [chemical binding]; other site 511995002302 cobalt ligand [ion binding]; other site 511995002303 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 511995002304 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 511995002305 heterodimer interface [polypeptide binding]; other site 511995002306 substrate interaction site [chemical binding]; other site 511995002307 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 511995002308 B12 binding site [chemical binding]; other site 511995002309 LysE type translocator; Region: LysE; cl00565 511995002310 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 511995002311 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 511995002312 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 511995002313 Predicted methyltransferases [General function prediction only]; Region: COG0313 511995002314 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 511995002315 putative SAM binding site [chemical binding]; other site 511995002316 putative homodimer interface [polypeptide binding]; other site 511995002317 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 511995002318 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 511995002319 active site 511995002320 ADP/pyrophosphate binding site [chemical binding]; other site 511995002321 dimerization interface [polypeptide binding]; other site 511995002322 allosteric effector site; other site 511995002323 fructose-1,6-bisphosphate binding site; other site 511995002324 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 511995002325 tartrate dehydrogenase; Region: TTC; TIGR02089 511995002326 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 511995002327 ATP binding site [chemical binding]; other site 511995002328 active site 511995002329 substrate binding site [chemical binding]; other site 511995002330 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 511995002331 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 511995002332 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 511995002333 shikimate binding site; other site 511995002334 NAD(P) binding site [chemical binding]; other site 511995002335 adenylosuccinate lyase; Provisional; Region: PRK09285 511995002336 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 511995002337 tetramer interface [polypeptide binding]; other site 511995002338 active site 511995002339 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 511995002340 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511995002341 RNA binding surface [nucleotide binding]; other site 511995002342 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 511995002343 active site 511995002344 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 511995002345 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 511995002346 putative dimer interface [polypeptide binding]; other site 511995002347 putative anticodon binding site; other site 511995002348 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 511995002349 homodimer interface [polypeptide binding]; other site 511995002350 motif 1; other site 511995002351 motif 2; other site 511995002352 active site 511995002353 motif 3; other site 511995002354 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 511995002355 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511995002356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511995002357 homodimer interface [polypeptide binding]; other site 511995002358 catalytic residue [active] 511995002359 GMP synthase; Reviewed; Region: guaA; PRK00074 511995002360 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 511995002361 AMP/PPi binding site [chemical binding]; other site 511995002362 candidate oxyanion hole; other site 511995002363 catalytic triad [active] 511995002364 potential glutamine specificity residues [chemical binding]; other site 511995002365 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 511995002366 ATP Binding subdomain [chemical binding]; other site 511995002367 Ligand Binding sites [chemical binding]; other site 511995002368 Dimerization subdomain; other site 511995002369 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 511995002370 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 511995002371 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 511995002372 Surface antigen; Region: Bac_surface_Ag; pfam01103 511995002373 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 511995002374 glutamate racemase; Provisional; Region: PRK00865 511995002375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511995002376 non-specific DNA binding site [nucleotide binding]; other site 511995002377 salt bridge; other site 511995002378 sequence-specific DNA binding site [nucleotide binding]; other site 511995002379 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 511995002380 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 511995002381 FAD binding pocket [chemical binding]; other site 511995002382 FAD binding motif [chemical binding]; other site 511995002383 phosphate binding motif [ion binding]; other site 511995002384 beta-alpha-beta structure motif; other site 511995002385 NAD binding pocket [chemical binding]; other site 511995002386 Iron coordination center [ion binding]; other site 511995002387 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 511995002388 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 511995002389 heterodimer interface [polypeptide binding]; other site 511995002390 active site 511995002391 FMN binding site [chemical binding]; other site 511995002392 homodimer interface [polypeptide binding]; other site 511995002393 substrate binding site [chemical binding]; other site 511995002394 signal recognition particle protein; Provisional; Region: PRK10867 511995002395 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 511995002396 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 511995002397 P loop; other site 511995002398 GTP binding site [chemical binding]; other site 511995002399 Signal peptide binding domain; Region: SRP_SPB; pfam02978 511995002400 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 511995002401 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 511995002402 putative tRNA-binding site [nucleotide binding]; other site 511995002403 B3/4 domain; Region: B3_4; pfam03483 511995002404 tRNA synthetase B5 domain; Region: B5; pfam03484 511995002405 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 511995002406 motif 1; other site 511995002407 dimer interface [polypeptide binding]; other site 511995002408 active site 511995002409 motif 2; other site 511995002410 motif 3; other site 511995002411 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 511995002412 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 511995002413 phosphoglyceromutase; Provisional; Region: PRK05434 511995002414 putative oxidoreductase; Provisional; Region: PRK12831 511995002415 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511995002416 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511995002417 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 511995002418 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 511995002419 FAD binding pocket [chemical binding]; other site 511995002420 FAD binding motif [chemical binding]; other site 511995002421 phosphate binding motif [ion binding]; other site 511995002422 beta-alpha-beta structure motif; other site 511995002423 NAD binding pocket [chemical binding]; other site 511995002424 Iron coordination center [ion binding]; other site 511995002425 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 511995002426 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 511995002427 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 511995002428 nucleoside/Zn binding site; other site 511995002429 dimer interface [polypeptide binding]; other site 511995002430 catalytic motif [active] 511995002431 Oligomerisation domain; Region: Oligomerisation; cl00519 511995002432 FtsH Extracellular; Region: FtsH_ext; pfam06480 511995002433 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 511995002434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511995002435 Walker A motif; other site 511995002436 ATP binding site [chemical binding]; other site 511995002437 Walker B motif; other site 511995002438 arginine finger; other site 511995002439 Peptidase family M41; Region: Peptidase_M41; pfam01434 511995002440 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 511995002441 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 511995002442 2-isopropylmalate synthase; Validated; Region: PRK00915 511995002443 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 511995002444 active site 511995002445 catalytic residues [active] 511995002446 metal binding site [ion binding]; metal-binding site 511995002447 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 511995002448 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 511995002449 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 511995002450 substrate binding site [chemical binding]; other site 511995002451 ligand binding site [chemical binding]; other site 511995002452 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 511995002453 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 511995002454 substrate binding site [chemical binding]; other site 511995002455 (R)-citramalate synthase; Provisional; Region: PRK09389 511995002456 Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945 511995002457 active site 511995002458 catalytic residues [active] 511995002459 metal binding site [ion binding]; metal-binding site 511995002460 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 511995002461 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 511995002462 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 511995002463 active site 511995002464 substrate-binding site [chemical binding]; other site 511995002465 metal-binding site [ion binding] 511995002466 ATP binding site [chemical binding]; other site 511995002467 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 511995002468 active site 511995002469 dimerization interface [polypeptide binding]; other site 511995002470 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 511995002471 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 511995002472 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 511995002473 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 511995002474 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 511995002475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511995002476 S-adenosylmethionine binding site [chemical binding]; other site 511995002477 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 511995002478 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 511995002479 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 511995002480 dimerization interface [polypeptide binding]; other site 511995002481 active site 511995002482 S-adenosylmethionine synthetase; Validated; Region: PRK05250 511995002483 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 511995002484 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 511995002485 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 511995002486 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 511995002487 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 511995002488 Cl- selectivity filter; other site 511995002489 Cl- binding residues [ion binding]; other site 511995002490 pore gating glutamate residue; other site 511995002491 dimer interface [polypeptide binding]; other site 511995002492 FOG: CBS domain [General function prediction only]; Region: COG0517 511995002493 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 511995002494 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 511995002495 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 511995002496 dimerization interface [polypeptide binding]; other site 511995002497 ATP binding site [chemical binding]; other site 511995002498 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 511995002499 dimerization interface [polypeptide binding]; other site 511995002500 ATP binding site [chemical binding]; other site 511995002501 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 511995002502 putative active site [active] 511995002503 catalytic triad [active] 511995002504 Mechanosensitive ion channel; Region: MS_channel; pfam00924 511995002505 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 511995002506 active site 511995002507 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 511995002508 Peptidase family U32; Region: Peptidase_U32; pfam01136 511995002509 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 511995002510 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 511995002511 PYR/PP interface [polypeptide binding]; other site 511995002512 dimer interface [polypeptide binding]; other site 511995002513 TPP binding site [chemical binding]; other site 511995002514 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 511995002515 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 511995002516 TPP-binding site [chemical binding]; other site 511995002517 dimer interface [polypeptide binding]; other site 511995002518 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 511995002519 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 511995002520 putative valine binding site [chemical binding]; other site 511995002521 dimer interface [polypeptide binding]; other site 511995002522 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 511995002523 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 511995002524 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 511995002525 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 511995002526 RmuC family; Region: RmuC; pfam02646 511995002527 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 511995002528 Flavoprotein; Region: Flavoprotein; pfam02441 511995002529 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 511995002530 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 511995002531 homotrimer interaction site [polypeptide binding]; other site 511995002532 putative active site [active] 511995002533 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 511995002534 Part of AAA domain; Region: AAA_19; pfam13245 511995002535 Family description; Region: UvrD_C_2; pfam13538 511995002536 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 511995002537 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 511995002538 Nitrogen regulatory protein P-II; Region: P-II; smart00938 511995002539 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 511995002540 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 511995002541 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 511995002542 active site 511995002543 trimer interface [polypeptide binding]; other site 511995002544 allosteric site; other site 511995002545 active site lid [active] 511995002546 hexamer (dimer of trimers) interface [polypeptide binding]; other site 511995002547 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 511995002548 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 511995002549 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 511995002550 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 511995002551 putative active site; other site 511995002552 catalytic triad [active] 511995002553 putative dimer interface [polypeptide binding]; other site 511995002554 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 511995002555 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 511995002556 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 511995002557 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 511995002558 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 511995002559 homodimer interface [polypeptide binding]; other site 511995002560 NADP binding site [chemical binding]; other site 511995002561 substrate binding site [chemical binding]; other site 511995002562 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 511995002563 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 511995002564 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 511995002565 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 511995002566 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 511995002567 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 511995002568 HflX GTPase family; Region: HflX; cd01878 511995002569 G1 box; other site 511995002570 GTP/Mg2+ binding site [chemical binding]; other site 511995002571 Switch I region; other site 511995002572 G2 box; other site 511995002573 G3 box; other site 511995002574 Switch II region; other site 511995002575 G4 box; other site 511995002576 G5 box; other site 511995002577 amino acid transporter; Region: 2A0306; TIGR00909 511995002578 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 511995002579 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 511995002580 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 511995002581 DNA binding site [nucleotide binding] 511995002582 active site 511995002583 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 511995002584 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 511995002585 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 511995002586 active site 511995002587 dimer interface [polypeptide binding]; other site 511995002588 effector binding site; other site 511995002589 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 511995002590 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 511995002591 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 511995002592 active site 511995002593 dimer interface [polypeptide binding]; other site 511995002594 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 511995002595 dimer interface [polypeptide binding]; other site 511995002596 active site 511995002597 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 511995002598 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 511995002599 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 511995002600 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 511995002601 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 511995002602 dimer interface [polypeptide binding]; other site 511995002603 putative anticodon binding site; other site 511995002604 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 511995002605 motif 1; other site 511995002606 active site 511995002607 motif 2; other site 511995002608 motif 3; other site 511995002609 recombination protein F; Reviewed; Region: recF; PRK00064 511995002610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511995002611 Walker A/P-loop; other site 511995002612 ATP binding site [chemical binding]; other site 511995002613 Q-loop/lid; other site 511995002614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511995002615 ABC transporter signature motif; other site 511995002616 Walker B; other site 511995002617 D-loop; other site 511995002618 H-loop/switch region; other site 511995002619 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 511995002620 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 511995002621 nucleotide binding pocket [chemical binding]; other site 511995002622 K-X-D-G motif; other site 511995002623 catalytic site [active] 511995002624 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 511995002625 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 511995002626 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 511995002627 Dimer interface [polypeptide binding]; other site 511995002628 BRCT sequence motif; other site 511995002629 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14970 511995002630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511995002631 Walker A motif; other site 511995002632 ATP binding site [chemical binding]; other site 511995002633 Walker B motif; other site 511995002634 arginine finger; other site 511995002635 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 511995002636 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 511995002637 dimer interface [polypeptide binding]; other site 511995002638 substrate binding site [chemical binding]; other site 511995002639 ATP binding site [chemical binding]; other site 511995002640 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 511995002641 ThiC-associated domain; Region: ThiC-associated; pfam13667 511995002642 ThiC family; Region: ThiC; pfam01964 511995002643 Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: LeuS; COG0495 511995002644 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511995002645 active site 511995002646 HIGH motif; other site 511995002647 nucleotide binding site [chemical binding]; other site 511995002648 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511995002649 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 511995002650 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511995002651 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511995002652 active site 511995002653 KMSKS motif; other site 511995002654 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 511995002655 tRNA binding surface [nucleotide binding]; other site 511995002656 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 511995002657 putative ABC transporter; Region: ycf24; CHL00085 511995002658 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 511995002659 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 511995002660 putative acyl-acceptor binding pocket; other site 511995002661 aspartate kinase; Validated; Region: PRK09181 511995002662 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 511995002663 nucleotide binding site [chemical binding]; other site 511995002664 substrate binding site [chemical binding]; other site 511995002665 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 511995002666 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 511995002667 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 511995002668 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 511995002669 active site 511995002670 substrate binding site [chemical binding]; other site 511995002671 metal binding site [ion binding]; metal-binding site 511995002672 FeS assembly ATPase SufC; Region: sufC; TIGR01978 511995002673 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 511995002674 Walker A/P-loop; other site 511995002675 ATP binding site [chemical binding]; other site 511995002676 Q-loop/lid; other site 511995002677 ABC transporter signature motif; other site 511995002678 Walker B; other site 511995002679 D-loop; other site 511995002680 H-loop/switch region; other site 511995002681 FeS assembly protein SufD; Region: sufD; TIGR01981 511995002682 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 511995002683 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 511995002684 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 511995002685 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511995002686 catalytic residue [active] 511995002687 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 511995002688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511995002689 ATP binding site [chemical binding]; other site 511995002690 Mg2+ binding site [ion binding]; other site 511995002691 G-X-G motif; other site 511995002692 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 511995002693 ATP binding site [chemical binding]; other site 511995002694 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 511995002695 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 511995002696 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 511995002697 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 511995002698 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511995002699 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511995002700 DNA polymerase III subunit beta; Validated; Region: PRK05643 511995002701 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 511995002702 putative DNA binding surface [nucleotide binding]; other site 511995002703 dimer interface [polypeptide binding]; other site 511995002704 beta-clamp/translesion DNA polymerase binding surface; other site 511995002705 beta-clamp/clamp loader binding surface; other site 511995002706 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 511995002707 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 511995002708 active site 511995002709 catalytic site [active] 511995002710 substrate binding site [chemical binding]; other site 511995002711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511995002712 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511995002713 putative substrate translocation pore; other site 511995002714 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 511995002715 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 511995002716 active site 511995002717 intersubunit interface [polypeptide binding]; other site 511995002718 catalytic residue [active] 511995002719 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511995002720 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 511995002721 substrate binding site [chemical binding]; other site 511995002722 ATP binding site [chemical binding]; other site 511995002723 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 511995002724 SmpB-tmRNA interface; other site 511995002725 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 511995002726 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 511995002727 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 511995002728 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 511995002729 homodecamer interface [polypeptide binding]; other site 511995002730 GTP cyclohydrolase I; Provisional; Region: PLN03044 511995002731 active site 511995002732 putative catalytic site residues [active] 511995002733 zinc binding site [ion binding]; other site 511995002734 GTP-CH-I/GFRP interaction surface; other site 511995002735 Sporulation related domain; Region: SPOR; pfam05036 511995002736 triosephosphate isomerase; Provisional; Region: PRK14567 511995002737 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 511995002738 substrate binding site [chemical binding]; other site 511995002739 dimer interface [polypeptide binding]; other site 511995002740 catalytic triad [active] 511995002741 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 511995002742 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 511995002743 Tetramer interface [polypeptide binding]; other site 511995002744 active site 511995002745 FMN-binding site [chemical binding]; other site 511995002746 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 511995002747 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511995002748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511995002749 homodimer interface [polypeptide binding]; other site 511995002750 catalytic residue [active] 511995002751 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 511995002752 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 511995002753 putative catalytic residues [active] 511995002754 nucleotide binding site [chemical binding]; other site 511995002755 aspartate binding site [chemical binding]; other site 511995002756 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 511995002757 dimer interface [polypeptide binding]; other site 511995002758 putative threonine allosteric regulatory site; other site 511995002759 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 511995002760 putative threonine allosteric regulatory site; other site 511995002761 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 511995002762 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 511995002763 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 511995002764 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 511995002765 threonine synthase; Validated; Region: PRK09225 511995002766 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 511995002767 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511995002768 catalytic residue [active] 511995002769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511995002770 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 511995002771 Walker A/P-loop; other site 511995002772 ATP binding site [chemical binding]; other site 511995002773 Q-loop/lid; other site 511995002774 ABC transporter signature motif; other site 511995002775 Walker B; other site 511995002776 D-loop; other site 511995002777 H-loop/switch region; other site 511995002778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 511995002779 Walker A/P-loop; other site 511995002780 ATP binding site [chemical binding]; other site 511995002781 Q-loop/lid; other site 511995002782 ABC transporter signature motif; other site 511995002783 Walker B; other site 511995002784 D-loop; other site 511995002785 H-loop/switch region; other site 511995002786 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 511995002787 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 511995002788 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 511995002789 Glycogen synthase; Region: Glycogen_syn; pfam05693 511995002790 C-N hydrolase family amidase; Provisional; Region: PRK10438 511995002791 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 511995002792 putative active site [active] 511995002793 catalytic triad [active] 511995002794 dimer interface [polypeptide binding]; other site 511995002795 multimer interface [polypeptide binding]; other site 511995002796 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 511995002797 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 511995002798 TPP-binding site; other site 511995002799 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 511995002800 PYR/PP interface [polypeptide binding]; other site 511995002801 dimer interface [polypeptide binding]; other site 511995002802 TPP binding site [chemical binding]; other site 511995002803 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511995002804 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 511995002805 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 511995002806 active site 511995002807 NTP binding site [chemical binding]; other site 511995002808 metal binding triad [ion binding]; metal-binding site 511995002809 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 511995002810 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511995002811 Zn2+ binding site [ion binding]; other site 511995002812 Mg2+ binding site [ion binding]; other site 511995002813 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 511995002814 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 511995002815 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 511995002816 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 511995002817 homotrimer interaction site [polypeptide binding]; other site 511995002818 zinc binding site [ion binding]; other site 511995002819 CDP-binding sites; other site 511995002820 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 511995002821 Ligand binding site [chemical binding]; other site 511995002822 Electron transfer flavoprotein domain; Region: ETF; pfam01012 511995002823 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 511995002824 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 511995002825 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 511995002826 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 511995002827 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 511995002828 active site 511995002829 Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186 511995002830 multiple promoter invertase; Provisional; Region: mpi; PRK13413 511995002831 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 511995002832 catalytic residues [active] 511995002833 catalytic nucleophile [active] 511995002834 Presynaptic Site I dimer interface [polypeptide binding]; other site 511995002835 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 511995002836 Synaptic Flat tetramer interface [polypeptide binding]; other site 511995002837 Synaptic Site I dimer interface [polypeptide binding]; other site 511995002838 DNA binding site [nucleotide binding] 511995002839 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 511995002840 Protein of unknown function (DUF805); Region: DUF805; pfam05656 511995002841 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 511995002842 catalytic residues [active] 511995002843 catalytic nucleophile [active] 511995002844 Presynaptic Site I dimer interface [polypeptide binding]; other site 511995002845 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 511995002846 Synaptic Flat tetramer interface [polypeptide binding]; other site 511995002847 Synaptic Site I dimer interface [polypeptide binding]; other site 511995002848 DNA binding site [nucleotide binding] 511995002849 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 511995002850 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 511995002851 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 511995002852 active site 511995002853 metal binding site [ion binding]; metal-binding site 511995002854 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 511995002855 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 511995002856 Peptidase family M23; Region: Peptidase_M23; pfam01551 511995002857 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 511995002858 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 511995002859 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 511995002860 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 511995002861 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511995002862 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511995002863 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511995002864 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 511995002865 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 511995002866 active site 511995002867 homodimer interface [polypeptide binding]; other site 511995002868 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 511995002869 ThiS interaction site; other site 511995002870 putative active site [active] 511995002871 tetramer interface [polypeptide binding]; other site 511995002872 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 511995002873 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511995002874 FeS/SAM binding site; other site 511995002875 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 511995002876 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 511995002877 thiamine phosphate binding site [chemical binding]; other site 511995002878 active site 511995002879 pyrophosphate binding site [ion binding]; other site 511995002880 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 511995002881 thiS-thiF/thiG interaction site; other site 511995002882 GTPase RsgA; Reviewed; Region: PRK00098 511995002883 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 511995002884 RNA binding site [nucleotide binding]; other site 511995002885 homodimer interface [polypeptide binding]; other site 511995002886 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 511995002887 GTPase/Zn-binding domain interface [polypeptide binding]; other site 511995002888 GTP/Mg2+ binding site [chemical binding]; other site 511995002889 G4 box; other site 511995002890 G5 box; other site 511995002891 G1 box; other site 511995002892 Switch I region; other site 511995002893 G2 box; other site 511995002894 G3 box; other site 511995002895 Switch II region; other site 511995002896 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 511995002897 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 511995002898 gamma-glutamyl kinase; Provisional; Region: PRK05429 511995002899 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 511995002900 nucleotide binding site [chemical binding]; other site 511995002901 homotetrameric interface [polypeptide binding]; other site 511995002902 putative phosphate binding site [ion binding]; other site 511995002903 putative allosteric binding site; other site 511995002904 PUA domain; Region: PUA; pfam01472 511995002905 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 511995002906 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 511995002907 putative catalytic cysteine [active] 511995002908 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 511995002909 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 511995002910 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 511995002911 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 511995002912 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 511995002913 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 511995002914 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 511995002915 Probable Catalytic site; other site 511995002916 metal-binding site 511995002917 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 511995002918 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 511995002919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511995002920 FeS/SAM binding site; other site 511995002921 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 511995002922 putative active site [active] 511995002923 dimerization interface [polypeptide binding]; other site 511995002924 putative tRNAtyr binding site [nucleotide binding]; other site 511995002925 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 511995002926 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 511995002927 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 511995002928 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 511995002929 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 511995002930 nucleotide binding site [chemical binding]; other site 511995002931 N-acetyl-L-glutamate binding site [chemical binding]; other site 511995002932 Peptidase family M49; Region: Peptidase_M49; pfam03571 511995002933 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 511995002934 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 511995002935 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511995002936 catalytic residue [active] 511995002937 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 511995002938 DNA gyrase subunit A; Validated; Region: PRK05560 511995002939 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 511995002940 CAP-like domain; other site 511995002941 active site 511995002942 primary dimer interface [polypeptide binding]; other site 511995002943 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511995002944 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511995002945 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511995002946 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511995002947 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511995002948 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511995002949 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 511995002950 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 511995002951 dimer interface [polypeptide binding]; other site 511995002952 motif 1; other site 511995002953 active site 511995002954 motif 2; other site 511995002955 motif 3; other site 511995002956 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 511995002957 anticodon binding site; other site 511995002958 GTP-binding protein LepA; Provisional; Region: PRK05433 511995002959 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 511995002960 G1 box; other site 511995002961 putative GEF interaction site [polypeptide binding]; other site 511995002962 GTP/Mg2+ binding site [chemical binding]; other site 511995002963 Switch I region; other site 511995002964 G2 box; other site 511995002965 G3 box; other site 511995002966 Switch II region; other site 511995002967 G4 box; other site 511995002968 G5 box; other site 511995002969 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 511995002970 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 511995002971 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 511995002972 UGMP family protein; Validated; Region: PRK09604 511995002973 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 511995002974 Peptidase family M48; Region: Peptidase_M48; pfam01435 511995002975 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 511995002976 Pantoate-beta-alanine ligase; Region: PanC; cd00560 511995002977 pantoate--beta-alanine ligase; Region: panC; TIGR00018 511995002978 active site 511995002979 ATP-binding site [chemical binding]; other site 511995002980 pantoate-binding site; other site 511995002981 HXXH motif; other site 511995002982 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 511995002983 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 511995002984 Mg++ binding site [ion binding]; other site 511995002985 putative catalytic motif [active] 511995002986 putative substrate binding site [chemical binding]; other site 511995002987 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 511995002988 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511995002989 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511995002990 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511995002991 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 511995002992 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 511995002993 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 511995002994 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 511995002995 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 511995002996 MraW methylase family; Region: Methyltransf_5; cl17771 511995002997 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 511995002998 putative ligand binding site [chemical binding]; other site 511995002999 putative NAD binding site [chemical binding]; other site 511995003000 putative catalytic site [active] 511995003001 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 511995003002 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 511995003003 dimer interface [polypeptide binding]; other site 511995003004 active site 511995003005 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511995003006 catalytic residues [active] 511995003007 substrate binding site [chemical binding]; other site 511995003008 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 511995003009 oligomerization interface [polypeptide binding]; other site 511995003010 active site 511995003011 metal binding site [ion binding]; metal-binding site 511995003012 CAAX protease self-immunity; Region: Abi; pfam02517 511995003013 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 511995003014 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511995003015 catalytic residue [active] 511995003016 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 511995003017 G1 box; other site 511995003018 GTP/Mg2+ binding site [chemical binding]; other site 511995003019 Switch I region; other site 511995003020 G2 box; other site 511995003021 G3 box; other site 511995003022 Switch II region; other site 511995003023 G4 box; other site 511995003024 G5 box; other site 511995003025 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 511995003026 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 511995003027 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 511995003028 dimer interface [polypeptide binding]; other site 511995003029 active site 511995003030 CoA binding pocket [chemical binding]; other site 511995003031 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 511995003032 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 511995003033 hinge; other site 511995003034 active site 511995003035 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 511995003036 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 511995003037 dimer interface [polypeptide binding]; other site 511995003038 active site 511995003039 glycine-pyridoxal phosphate binding site [chemical binding]; other site 511995003040 folate binding site [chemical binding]; other site 511995003041 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 511995003042 putative nucleotide binding site [chemical binding]; other site 511995003043 uridine monophosphate binding site [chemical binding]; other site 511995003044 homohexameric interface [polypeptide binding]; other site 511995003045 ribosome recycling factor; Reviewed; Region: frr; PRK00083 511995003046 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 511995003047 hinge region; other site 511995003048 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 511995003049 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 511995003050 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 511995003051 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 511995003052 active site 511995003053 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 511995003054 Glycoprotease family; Region: Peptidase_M22; pfam00814 511995003055 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 511995003056 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 511995003057 dimer interface [polypeptide binding]; other site 511995003058 anticodon binding site; other site 511995003059 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 511995003060 homodimer interface [polypeptide binding]; other site 511995003061 motif 1; other site 511995003062 active site 511995003063 motif 2; other site 511995003064 GAD domain; Region: GAD; pfam02938 511995003065 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 511995003066 active site 511995003067 motif 3; other site