-- dump date 20140619_023531 -- class Genbank::misc_feature -- table misc_feature_note -- id note 204669000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 204669000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 204669000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669000004 Walker A motif; other site 204669000005 ATP binding site [chemical binding]; other site 204669000006 Walker B motif; other site 204669000007 arginine finger; other site 204669000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 204669000009 DnaA box-binding interface [nucleotide binding]; other site 204669000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 204669000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 204669000012 putative DNA binding surface [nucleotide binding]; other site 204669000013 dimer interface [polypeptide binding]; other site 204669000014 beta-clamp/clamp loader binding surface; other site 204669000015 beta-clamp/translesion DNA polymerase binding surface; other site 204669000016 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 204669000017 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 204669000018 nucleotide binding site [chemical binding]; other site 204669000019 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 204669000020 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 204669000021 dimer interface [polypeptide binding]; other site 204669000022 active site 204669000023 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 204669000024 dimer interface [polypeptide binding]; other site 204669000025 active site 204669000026 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 204669000027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669000028 putative substrate translocation pore; other site 204669000029 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 204669000030 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 204669000031 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 204669000032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669000033 ATP binding site [chemical binding]; other site 204669000034 Mg2+ binding site [ion binding]; other site 204669000035 G-X-G motif; other site 204669000036 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 204669000037 anchoring element; other site 204669000038 dimer interface [polypeptide binding]; other site 204669000039 ATP binding site [chemical binding]; other site 204669000040 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 204669000041 active site 204669000042 putative metal-binding site [ion binding]; other site 204669000043 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 204669000044 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 204669000045 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 204669000046 active site 204669000047 Zn binding site [ion binding]; other site 204669000048 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 204669000049 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 204669000050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 204669000051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 204669000052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669000053 S-adenosylmethionine binding site [chemical binding]; other site 204669000054 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 204669000055 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 204669000056 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 204669000057 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 204669000058 GTPase CgtA; Reviewed; Region: obgE; PRK12299 204669000059 GTP1/OBG; Region: GTP1_OBG; pfam01018 204669000060 Obg GTPase; Region: Obg; cd01898 204669000061 G1 box; other site 204669000062 GTP/Mg2+ binding site [chemical binding]; other site 204669000063 Switch I region; other site 204669000064 G2 box; other site 204669000065 G3 box; other site 204669000066 Switch II region; other site 204669000067 G4 box; other site 204669000068 G5 box; other site 204669000069 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 204669000070 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 204669000071 active site 204669000072 (T/H)XGH motif; other site 204669000073 Oligomerisation domain; Region: Oligomerisation; pfam02410 204669000074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669000075 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 204669000076 Walker A motif; other site 204669000077 ATP binding site [chemical binding]; other site 204669000078 Walker B motif; other site 204669000079 arginine finger; other site 204669000080 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669000081 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 204669000082 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 204669000083 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 204669000084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669000085 NAD(P) binding site [chemical binding]; other site 204669000086 active site 204669000087 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 204669000088 dimerization interface [polypeptide binding]; other site 204669000089 putative DNA binding site [nucleotide binding]; other site 204669000090 putative Zn2+ binding site [ion binding]; other site 204669000091 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 204669000092 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 204669000093 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 204669000094 FMN binding site [chemical binding]; other site 204669000095 active site 204669000096 catalytic residues [active] 204669000097 substrate binding site [chemical binding]; other site 204669000098 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 204669000099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 204669000100 motif II; other site 204669000101 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 204669000102 Predicted methyltransferases [General function prediction only]; Region: COG0313 204669000103 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 204669000104 putative SAM binding site [chemical binding]; other site 204669000105 putative homodimer interface [polypeptide binding]; other site 204669000106 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 204669000107 SnoaL-like domain; Region: SnoaL_3; pfam13474 204669000108 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669000109 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669000110 active site 204669000111 ATP binding site [chemical binding]; other site 204669000112 substrate binding site [chemical binding]; other site 204669000113 activation loop (A-loop); other site 204669000114 PEGA domain; Region: PEGA; pfam08308 204669000115 PEGA domain; Region: PEGA; pfam08308 204669000116 PEGA domain; Region: PEGA; pfam08308 204669000117 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669000118 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669000119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669000120 binding surface 204669000121 TPR motif; other site 204669000122 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669000123 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 204669000124 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 204669000125 ParB-like nuclease domain; Region: ParB; smart00470 204669000126 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 204669000127 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 204669000128 P-loop; other site 204669000129 Magnesium ion binding site [ion binding]; other site 204669000130 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 204669000131 Magnesium ion binding site [ion binding]; other site 204669000132 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 204669000133 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 204669000134 SnoaL-like domain; Region: SnoaL_3; pfam13474 204669000135 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 204669000136 adenosine deaminase; Provisional; Region: PRK09358 204669000137 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 204669000138 active site 204669000139 amino acid transporter; Region: 2A0306; TIGR00909 204669000140 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 204669000141 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 204669000142 Part of AAA domain; Region: AAA_19; pfam13245 204669000143 Family description; Region: UvrD_C_2; pfam13538 204669000144 Protein of unknown function (DUF971); Region: DUF971; pfam06155 204669000145 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 204669000146 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 204669000147 NodB motif; other site 204669000148 putative active site [active] 204669000149 putative catalytic site [active] 204669000150 putative Zn binding site [ion binding]; other site 204669000151 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 204669000152 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 204669000153 active site 204669000154 HIGH motif; other site 204669000155 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 204669000156 KMSKS motif; other site 204669000157 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669000158 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669000159 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669000160 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 204669000161 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 204669000162 putative NAD(P) binding site [chemical binding]; other site 204669000163 putative active site [active] 204669000164 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 204669000165 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 204669000166 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669000167 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 204669000168 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 204669000169 active site 204669000170 GIY-YIG motif/motif A; other site 204669000171 catalytic site [active] 204669000172 UvrB/uvrC motif; Region: UVR; pfam02151 204669000173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669000174 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 204669000175 Walker A motif; other site 204669000176 ATP binding site [chemical binding]; other site 204669000177 Walker B motif; other site 204669000178 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 204669000179 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 204669000180 TilS substrate C-terminal domain; Region: TilS_C; smart00977 204669000181 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 204669000182 active site 204669000183 FtsH Extracellular; Region: FtsH_ext; pfam06480 204669000184 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 204669000185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669000186 Walker A motif; other site 204669000187 ATP binding site [chemical binding]; other site 204669000188 Walker B motif; other site 204669000189 Peptidase family M41; Region: Peptidase_M41; pfam01434 204669000190 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669000191 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669000192 ligand binding site [chemical binding]; other site 204669000193 flexible hinge region; other site 204669000194 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 204669000195 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669000196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669000197 dimer interface [polypeptide binding]; other site 204669000198 phosphorylation site [posttranslational modification] 204669000199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669000200 ATP binding site [chemical binding]; other site 204669000201 Mg2+ binding site [ion binding]; other site 204669000202 G-X-G motif; other site 204669000203 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 204669000204 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 204669000205 Walker A motif; other site 204669000206 ATP binding site [chemical binding]; other site 204669000207 Walker B motif; other site 204669000208 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 204669000209 ATP binding site [chemical binding]; other site 204669000210 Walker A motif; other site 204669000211 Walker B motif; other site 204669000212 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 204669000213 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 204669000214 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 204669000215 Ligand Binding Site [chemical binding]; other site 204669000216 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 204669000217 Ligand Binding Site [chemical binding]; other site 204669000218 Response regulator receiver domain; Region: Response_reg; pfam00072 204669000219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669000220 active site 204669000221 phosphorylation site [posttranslational modification] 204669000222 intermolecular recognition site; other site 204669000223 dimerization interface [polypeptide binding]; other site 204669000224 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 204669000225 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 204669000226 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 204669000227 substrate binding site [chemical binding]; other site 204669000228 hexamer interface [polypeptide binding]; other site 204669000229 metal binding site [ion binding]; metal-binding site 204669000230 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 204669000231 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669000232 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669000233 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 204669000234 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 204669000235 PEGA domain; Region: PEGA; pfam08308 204669000236 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 204669000237 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 204669000238 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 204669000239 DinB superfamily; Region: DinB_2; pfam12867 204669000240 DinB family; Region: DinB; cl17821 204669000241 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 204669000242 IHF dimer interface [polypeptide binding]; other site 204669000243 IHF - DNA interface [nucleotide binding]; other site 204669000244 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 204669000245 catalytic center binding site [active] 204669000246 ATP binding site [chemical binding]; other site 204669000247 Response regulator receiver domain; Region: Response_reg; pfam00072 204669000248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 204669000249 active site 204669000250 phosphorylation site [posttranslational modification] 204669000251 intermolecular recognition site; other site 204669000252 dimerization interface [polypeptide binding]; other site 204669000253 PilZ domain; Region: PilZ; pfam07238 204669000254 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 204669000255 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 204669000256 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 204669000257 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 204669000258 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 204669000259 RNA/DNA hybrid binding site [nucleotide binding]; other site 204669000260 active site 204669000261 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 204669000262 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 204669000263 active site 204669000264 metal binding site [ion binding]; metal-binding site 204669000265 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 204669000266 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 204669000267 Walker A/P-loop; other site 204669000268 ATP binding site [chemical binding]; other site 204669000269 Q-loop/lid; other site 204669000270 ABC transporter signature motif; other site 204669000271 Walker B; other site 204669000272 D-loop; other site 204669000273 H-loop/switch region; other site 204669000274 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 204669000275 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 204669000276 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 204669000277 intracellular protease, PfpI family; Region: PfpI; TIGR01382 204669000278 potential catalytic triad [active] 204669000279 conserved cys residue [active] 204669000280 hypothetical protein; Provisional; Region: PRK10621 204669000281 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 204669000282 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 204669000283 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 204669000284 peptidase domain interface [polypeptide binding]; other site 204669000285 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 204669000286 active site 204669000287 catalytic triad [active] 204669000288 calcium binding site [ion binding]; other site 204669000289 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 204669000290 selenophosphate synthetase; Provisional; Region: PRK00943 204669000291 dimerization interface [polypeptide binding]; other site 204669000292 putative ATP binding site [chemical binding]; other site 204669000293 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 204669000294 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669000295 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000296 FtsX-like permease family; Region: FtsX; pfam02687 204669000297 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000298 FtsX-like permease family; Region: FtsX; pfam02687 204669000299 Yqey-like protein; Region: YqeY; pfam09424 204669000300 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 204669000301 peptidase domain interface [polypeptide binding]; other site 204669000302 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 204669000303 active site 204669000304 catalytic triad [active] 204669000305 calcium binding site [ion binding]; other site 204669000306 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 204669000307 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 204669000308 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 204669000309 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 204669000310 spermidine synthase; Provisional; Region: PRK03612 204669000311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669000312 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 204669000313 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 204669000314 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 204669000315 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 204669000316 catalytic residue [active] 204669000317 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 204669000318 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 204669000319 ligand binding site [chemical binding]; other site 204669000320 NAD binding site [chemical binding]; other site 204669000321 dimerization interface [polypeptide binding]; other site 204669000322 catalytic site [active] 204669000323 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 204669000324 putative L-serine binding site [chemical binding]; other site 204669000325 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 204669000326 active site 204669000327 Peptidase family M50; Region: Peptidase_M50; pfam02163 204669000328 putative substrate binding region [chemical binding]; other site 204669000329 FOG: CBS domain [General function prediction only]; Region: COG0517 204669000330 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 204669000331 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 204669000332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669000333 S-adenosylmethionine binding site [chemical binding]; other site 204669000334 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 204669000335 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 204669000336 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 204669000337 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 204669000338 putative acyl-acceptor binding pocket; other site 204669000339 Peptidase C26; Region: Peptidase_C26; pfam07722 204669000340 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 204669000341 catalytic triad [active] 204669000342 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 204669000343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669000344 NAD(P) binding site [chemical binding]; other site 204669000345 active site 204669000346 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 204669000347 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 204669000348 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 204669000349 amphipathic channel; other site 204669000350 Asn-Pro-Ala signature motifs; other site 204669000351 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 204669000352 homodimer interface [polypeptide binding]; other site 204669000353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669000354 catalytic residue [active] 204669000355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 204669000356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 204669000357 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 204669000358 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 204669000359 active site 204669000360 HIGH motif; other site 204669000361 nucleotide binding site [chemical binding]; other site 204669000362 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 204669000363 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 204669000364 active site 204669000365 KMSKS motif; other site 204669000366 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 204669000367 tRNA binding surface [nucleotide binding]; other site 204669000368 anticodon binding site; other site 204669000369 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 204669000370 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 204669000371 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 204669000372 dimerization interface [polypeptide binding]; other site 204669000373 active site 204669000374 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 204669000375 dimer interface [polypeptide binding]; other site 204669000376 [2Fe-2S] cluster binding site [ion binding]; other site 204669000377 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 204669000378 Biotin operon repressor [Transcription]; Region: BirA; COG1654 204669000379 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 204669000380 pantothenate kinase; Reviewed; Region: PRK13318 204669000381 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 204669000382 TRAM domain; Region: TRAM; pfam01938 204669000383 YCII-related domain; Region: YCII; cl00999 204669000384 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 204669000385 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 204669000386 Competence protein; Region: Competence; pfam03772 204669000387 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 204669000388 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 204669000389 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 204669000390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 204669000391 motif II; other site 204669000392 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 204669000393 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 204669000394 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 204669000395 Preprotein translocase subunit; Region: YajC; pfam02699 204669000396 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 204669000397 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 204669000398 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 204669000399 Protein export membrane protein; Region: SecD_SecF; pfam02355 204669000400 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669000401 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 204669000402 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 204669000403 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 204669000404 TolR protein; Region: tolR; TIGR02801 204669000405 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 204669000406 TPR repeat; Region: TPR_11; pfam13414 204669000407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669000408 binding surface 204669000409 TPR motif; other site 204669000410 TPR repeat; Region: TPR_11; pfam13414 204669000411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 204669000412 binding surface 204669000413 TPR motif; other site 204669000414 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 204669000415 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 204669000416 ATP-grasp domain; Region: ATP-grasp_4; cl17255 204669000417 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 204669000418 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 204669000419 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 204669000420 carboxyltransferase (CT) interaction site; other site 204669000421 biotinylation site [posttranslational modification]; other site 204669000422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669000423 non-specific DNA binding site [nucleotide binding]; other site 204669000424 salt bridge; other site 204669000425 sequence-specific DNA binding site [nucleotide binding]; other site 204669000426 HipA N-terminal domain; Region: Couple_hipA; pfam13657 204669000427 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 204669000428 HipA-like N-terminal domain; Region: HipA_N; pfam07805 204669000429 HipA-like C-terminal domain; Region: HipA_C; pfam07804 204669000430 SurA N-terminal domain; Region: SurA_N_3; cl07813 204669000431 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 204669000432 Thioredoxin; Region: Thioredoxin_4; pfam13462 204669000433 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 204669000434 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 204669000435 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 204669000436 Ligand Binding Site [chemical binding]; other site 204669000437 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 204669000438 Organic solvent tolerance protein; Region: OstA_C; pfam04453 204669000439 RDD family; Region: RDD; pfam06271 204669000440 Amino acid permease; Region: AA_permease_2; pfam13520 204669000441 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 204669000442 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 204669000443 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 204669000444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 204669000445 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 204669000446 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 204669000447 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 204669000448 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 204669000449 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 204669000450 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 204669000451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 204669000452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 204669000453 Protein of unknown function, DUF393; Region: DUF393; pfam04134 204669000454 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 204669000455 homotrimer interaction site [polypeptide binding]; other site 204669000456 putative active site [active] 204669000457 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 204669000458 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669000459 Zn2+ binding site [ion binding]; other site 204669000460 Mg2+ binding site [ion binding]; other site 204669000461 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 204669000462 synthetase active site [active] 204669000463 NTP binding site [chemical binding]; other site 204669000464 metal binding site [ion binding]; metal-binding site 204669000465 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 204669000466 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 204669000467 Radical SAM superfamily; Region: Radical_SAM; pfam04055 204669000468 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669000469 FeS/SAM binding site; other site 204669000470 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 204669000471 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 204669000472 YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779 204669000473 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 204669000474 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 204669000475 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 204669000476 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 204669000477 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 204669000478 catalytic residues [active] 204669000479 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 204669000480 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 204669000481 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 204669000482 active site 204669000483 HIGH motif; other site 204669000484 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 204669000485 active site 204669000486 KMSKS motif; other site 204669000487 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669000488 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 204669000489 GAF domain; Region: GAF_3; pfam13492 204669000490 GAF domain; Region: GAF_2; pfam13185 204669000491 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 204669000492 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 204669000493 metal binding site [ion binding]; metal-binding site 204669000494 active site 204669000495 I-site; other site 204669000496 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 204669000497 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669000498 Zn2+ binding site [ion binding]; other site 204669000499 Mg2+ binding site [ion binding]; other site 204669000500 Zinc finger domain; Region: ZnF_RBZ; smart00547 204669000501 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 204669000502 homotrimer interaction site [polypeptide binding]; other site 204669000503 zinc binding site [ion binding]; other site 204669000504 CDP-binding sites; other site 204669000505 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 204669000506 substrate binding site; other site 204669000507 dimer interface; other site 204669000508 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 204669000509 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 204669000510 putative active site [active] 204669000511 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 204669000512 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 204669000513 NAD(P) binding site [chemical binding]; other site 204669000514 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 204669000515 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 204669000516 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 204669000517 MPN+ (JAMM) motif; other site 204669000518 Zinc-binding site [ion binding]; other site 204669000519 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 204669000520 Interdomain contacts; other site 204669000521 Cytokine receptor motif; other site 204669000522 BNR repeat-like domain; Region: BNR_2; pfam13088 204669000523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 204669000524 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 204669000525 Asp-box motif; other site 204669000526 hypothetical protein; Validated; Region: PRK07411 204669000527 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 204669000528 ATP binding site [chemical binding]; other site 204669000529 substrate interface [chemical binding]; other site 204669000530 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 204669000531 active site residue [active] 204669000532 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 204669000533 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 204669000534 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 204669000535 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 204669000536 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 204669000537 metal binding site [ion binding]; metal-binding site 204669000538 active site 204669000539 I-site; other site 204669000540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 204669000541 Peptidase M15; Region: Peptidase_M15_3; cl01194 204669000542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 204669000543 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 204669000544 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 204669000545 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 204669000546 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 204669000547 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 204669000548 Penicillinase repressor; Region: Pencillinase_R; pfam03965 204669000549 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 204669000550 classical (c) SDRs; Region: SDR_c; cd05233 204669000551 NAD(P) binding site [chemical binding]; other site 204669000552 active site 204669000553 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 204669000554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669000555 Walker A motif; other site 204669000556 ATP binding site [chemical binding]; other site 204669000557 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 204669000558 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 204669000559 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 204669000560 active site 204669000561 HslU subunit interaction site [polypeptide binding]; other site 204669000562 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 204669000563 RxxxH motif; other site 204669000564 membrane protein insertase; Provisional; Region: PRK01318 204669000565 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 204669000566 Haemolytic domain; Region: Haemolytic; pfam01809 204669000567 Ribonuclease P; Region: Ribonuclease_P; pfam00825 204669000568 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 204669000569 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 204669000570 putative transporter; Provisional; Region: PRK11660 204669000571 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 204669000572 Sulfate transporter family; Region: Sulfate_transp; pfam00916 204669000573 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 204669000574 aconitate hydratase; Validated; Region: PRK09277 204669000575 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 204669000576 substrate binding site [chemical binding]; other site 204669000577 ligand binding site [chemical binding]; other site 204669000578 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 204669000579 substrate binding site [chemical binding]; other site 204669000580 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 204669000581 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669000582 Zn2+ binding site [ion binding]; other site 204669000583 Mg2+ binding site [ion binding]; other site 204669000584 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 204669000585 Domain of unknown function (DUF955); Region: DUF955; pfam06114 204669000586 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 204669000587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669000588 non-specific DNA binding site [nucleotide binding]; other site 204669000589 salt bridge; other site 204669000590 sequence-specific DNA binding site [nucleotide binding]; other site 204669000591 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 204669000592 SEC-C motif; Region: SEC-C; pfam02810 204669000593 manganese transport protein MntH; Reviewed; Region: PRK00701 204669000594 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 204669000595 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 204669000596 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 204669000597 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 204669000598 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 204669000599 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 204669000600 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 204669000601 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 204669000602 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 204669000603 active site 204669000604 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 204669000605 hypothetical protein; Provisional; Region: PRK07338 204669000606 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 204669000607 metal binding site [ion binding]; metal-binding site 204669000608 dimer interface [polypeptide binding]; other site 204669000609 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 204669000610 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 204669000611 Maf-like protein; Region: Maf; pfam02545 204669000612 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 204669000613 active site 204669000614 dimer interface [polypeptide binding]; other site 204669000615 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 204669000616 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 204669000617 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 204669000618 catalytic site [active] 204669000619 active site 204669000620 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 204669000621 ATP-binding site [chemical binding]; other site 204669000622 Gluconate-6-phosphate binding site [chemical binding]; other site 204669000623 Shikimate kinase; Region: SKI; pfam01202 204669000624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669000625 D-galactonate transporter; Region: 2A0114; TIGR00893 204669000626 putative substrate translocation pore; other site 204669000627 GTP-binding protein LepA; Provisional; Region: PRK05433 204669000628 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 204669000629 G1 box; other site 204669000630 putative GEF interaction site [polypeptide binding]; other site 204669000631 GTP/Mg2+ binding site [chemical binding]; other site 204669000632 Switch I region; other site 204669000633 G2 box; other site 204669000634 G3 box; other site 204669000635 Switch II region; other site 204669000636 G4 box; other site 204669000637 G5 box; other site 204669000638 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 204669000639 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 204669000640 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 204669000641 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 204669000642 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669000643 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 204669000644 periplasmic chaperone; Provisional; Region: PRK10780 204669000645 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 204669000646 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669000647 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669000648 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669000649 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669000650 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669000651 Surface antigen; Region: Bac_surface_Ag; pfam01103 204669000652 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 204669000653 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 204669000654 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 204669000655 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 204669000656 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 204669000657 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 204669000658 active site 204669000659 recombinase A; Provisional; Region: recA; PRK09354 204669000660 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 204669000661 hexamer interface [polypeptide binding]; other site 204669000662 Walker A motif; other site 204669000663 ATP binding site [chemical binding]; other site 204669000664 Walker B motif; other site 204669000665 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 204669000666 putative nucleotide binding site [chemical binding]; other site 204669000667 uridine monophosphate binding site [chemical binding]; other site 204669000668 homohexameric interface [polypeptide binding]; other site 204669000669 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 204669000670 ribosome recycling factor; Reviewed; Region: frr; PRK00083 204669000671 hinge region; other site 204669000672 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 204669000673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669000674 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669000675 active site 204669000676 ATP binding site [chemical binding]; other site 204669000677 substrate binding site [chemical binding]; other site 204669000678 activation loop (A-loop); other site 204669000679 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669000680 Helix-Turn-Helix DNA binding domain of putative Cfa-like transcription regulators; Region: HTH_Cfa-like_unk; cd04790 204669000681 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 204669000682 DNA binding residues [nucleotide binding] 204669000683 putative dimer interface [polypeptide binding]; other site 204669000684 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 204669000685 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 204669000686 NAD(P) binding site [chemical binding]; other site 204669000687 homotetramer interface [polypeptide binding]; other site 204669000688 homodimer interface [polypeptide binding]; other site 204669000689 active site 204669000690 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 204669000691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669000692 non-specific DNA binding site [nucleotide binding]; other site 204669000693 salt bridge; other site 204669000694 sequence-specific DNA binding site [nucleotide binding]; other site 204669000695 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669000696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669000697 active site 204669000698 phosphorylation site [posttranslational modification] 204669000699 intermolecular recognition site; other site 204669000700 dimerization interface [polypeptide binding]; other site 204669000701 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669000702 DNA binding residues [nucleotide binding] 204669000703 dimerization interface [polypeptide binding]; other site 204669000704 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 204669000705 GIY-YIG motif/motif A; other site 204669000706 OmpA family; Region: OmpA; pfam00691 204669000707 ligand binding site [chemical binding]; other site 204669000708 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 204669000709 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 204669000710 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 204669000711 DNA binding site [nucleotide binding] 204669000712 active site 204669000713 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 204669000714 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 204669000715 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 204669000716 active site 204669000717 substrate binding site [chemical binding]; other site 204669000718 metal binding site [ion binding]; metal-binding site 204669000719 YbbR-like protein; Region: YbbR; pfam07949 204669000720 YbbR-like protein; Region: YbbR; pfam07949 204669000721 Uncharacterized conserved protein [Function unknown]; Region: COG1624 204669000722 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 204669000723 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 204669000724 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 204669000725 generic binding surface II; other site 204669000726 generic binding surface I; other site 204669000727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 204669000728 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669000729 phosphorylation site [posttranslational modification] 204669000730 intermolecular recognition site; other site 204669000731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 204669000732 active site 204669000733 phosphorylation site [posttranslational modification] 204669000734 intermolecular recognition site; other site 204669000735 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 204669000736 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 204669000737 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 204669000738 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 204669000739 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 204669000740 nucleotide binding site [chemical binding]; other site 204669000741 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 204669000742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 204669000743 DNA-binding site [nucleotide binding]; DNA binding site 204669000744 UTRA domain; Region: UTRA; pfam07702 204669000745 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 204669000746 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 204669000747 Walker A/P-loop; other site 204669000748 ATP binding site [chemical binding]; other site 204669000749 Q-loop/lid; other site 204669000750 ABC transporter signature motif; other site 204669000751 Walker B; other site 204669000752 D-loop; other site 204669000753 H-loop/switch region; other site 204669000754 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 204669000755 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 204669000756 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 204669000757 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 204669000758 NodB motif; other site 204669000759 active site 204669000760 catalytic site [active] 204669000761 metal binding site [ion binding]; metal-binding site 204669000762 Caspase domain; Region: Peptidase_C14; pfam00656 204669000763 TPR repeat; Region: TPR_11; pfam13414 204669000764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669000765 binding surface 204669000766 TPR motif; other site 204669000767 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669000768 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000769 FtsX-like permease family; Region: FtsX; pfam02687 204669000770 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000771 FtsX-like permease family; Region: FtsX; pfam02687 204669000772 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 204669000773 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 204669000774 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669000775 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 204669000776 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 204669000777 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669000778 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669000779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669000780 binding surface 204669000781 TPR motif; other site 204669000782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669000783 binding surface 204669000784 TPR motif; other site 204669000785 CHAT domain; Region: CHAT; pfam12770 204669000786 Putative zinc-finger; Region: zf-HC2; pfam13490 204669000787 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 204669000788 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669000789 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669000790 DNA binding residues [nucleotide binding] 204669000791 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669000792 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000793 FtsX-like permease family; Region: FtsX; pfam02687 204669000794 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000795 FtsX-like permease family; Region: FtsX; pfam02687 204669000796 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 204669000797 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 204669000798 active site 204669000799 catalytic tetrad [active] 204669000800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 204669000801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 204669000802 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 204669000803 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 204669000804 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 204669000805 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 204669000806 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 204669000807 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 204669000808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 204669000809 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 204669000810 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 204669000811 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 204669000812 active site 204669000813 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 204669000814 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 204669000815 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 204669000816 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 204669000817 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669000818 Outer membrane efflux protein; Region: OEP; pfam02321 204669000819 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 204669000820 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669000821 dimerization interface [polypeptide binding]; other site 204669000822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669000823 dimer interface [polypeptide binding]; other site 204669000824 phosphorylation site [posttranslational modification] 204669000825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669000826 ATP binding site [chemical binding]; other site 204669000827 Mg2+ binding site [ion binding]; other site 204669000828 G-X-G motif; other site 204669000829 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669000830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669000831 active site 204669000832 phosphorylation site [posttranslational modification] 204669000833 intermolecular recognition site; other site 204669000834 dimerization interface [polypeptide binding]; other site 204669000835 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669000836 DNA binding site [nucleotide binding] 204669000837 Uncharacterized conserved protein [Function unknown]; Region: COG3391 204669000838 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 204669000839 active site 204669000840 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 204669000841 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669000842 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 204669000843 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669000844 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669000845 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 204669000846 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 204669000847 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 204669000848 Family description; Region: VCBS; pfam13517 204669000849 Family description; Region: VCBS; pfam13517 204669000850 Family description; Region: VCBS; pfam13517 204669000851 Family description; Region: VCBS; pfam13517 204669000852 Family description; Region: VCBS; pfam13517 204669000853 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 204669000854 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 204669000855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 204669000856 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 204669000857 active site 204669000858 catalytic residues [active] 204669000859 ribulokinase; Provisional; Region: PRK04123 204669000860 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 204669000861 N- and C-terminal domain interface [polypeptide binding]; other site 204669000862 active site 204669000863 MgATP binding site [chemical binding]; other site 204669000864 catalytic site [active] 204669000865 metal binding site [ion binding]; metal-binding site 204669000866 carbohydrate binding site [chemical binding]; other site 204669000867 homodimer interface [polypeptide binding]; other site 204669000868 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 204669000869 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 204669000870 Na binding site [ion binding]; other site 204669000871 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 204669000872 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 204669000873 intersubunit interface [polypeptide binding]; other site 204669000874 active site 204669000875 Zn2+ binding site [ion binding]; other site 204669000876 L-arabinose isomerase; Provisional; Region: PRK02929 204669000877 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 204669000878 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 204669000879 trimer interface [polypeptide binding]; other site 204669000880 putative substrate binding site [chemical binding]; other site 204669000881 putative metal binding site [ion binding]; other site 204669000882 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 204669000883 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 204669000884 Transcriptional regulators [Transcription]; Region: PurR; COG1609 204669000885 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 204669000886 DNA binding site [nucleotide binding] 204669000887 domain linker motif; other site 204669000888 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 204669000889 dimerization interface [polypeptide binding]; other site 204669000890 ligand binding site [chemical binding]; other site 204669000891 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 204669000892 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 204669000893 Domain of unknown function DUF11; Region: DUF11; cl17728 204669000894 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 204669000895 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 204669000896 Metal-binding active site; metal-binding site 204669000897 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 204669000898 short chain dehydrogenase; Provisional; Region: PRK07677 204669000899 NAD(P) binding site [chemical binding]; other site 204669000900 substrate binding site [chemical binding]; other site 204669000901 homotetramer interface [polypeptide binding]; other site 204669000902 active site 204669000903 homodimer interface [polypeptide binding]; other site 204669000904 Phospholipase B; Region: Phospholip_B; pfam04916 204669000905 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 204669000906 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 204669000907 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 204669000908 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 204669000909 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 204669000910 DNA binding residues [nucleotide binding] 204669000911 dimer interface [polypeptide binding]; other site 204669000912 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 204669000913 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 204669000914 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669000915 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000916 FtsX-like permease family; Region: FtsX; pfam02687 204669000917 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000918 FtsX-like permease family; Region: FtsX; pfam02687 204669000919 ADP-glucose phosphorylase; Region: PLN02643 204669000920 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 204669000921 dimer interface [polypeptide binding]; other site 204669000922 active site 204669000923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 204669000924 Transposase; Region: DEDD_Tnp_IS110; pfam01548 204669000925 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 204669000926 Beta-propeller repeat; Region: SBBP; pfam06739 204669000927 Beta-propeller repeat; Region: SBBP; pfam06739 204669000928 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 204669000929 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 204669000930 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 204669000931 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 204669000932 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669000933 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 204669000934 PGAP1-like protein; Region: PGAP1; pfam07819 204669000935 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 204669000936 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 204669000937 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 204669000938 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 204669000939 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 204669000940 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 204669000941 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 204669000942 Ca binding site [ion binding]; other site 204669000943 active site 204669000944 catalytic site [active] 204669000945 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 204669000946 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 204669000947 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 204669000948 ABC1 family; Region: ABC1; cl17513 204669000949 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 204669000950 active site 204669000951 ATP binding site [chemical binding]; other site 204669000952 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 204669000953 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 204669000954 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669000955 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669000956 ligand binding site [chemical binding]; other site 204669000957 flexible hinge region; other site 204669000958 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 204669000959 non-specific DNA interactions [nucleotide binding]; other site 204669000960 DNA binding site [nucleotide binding] 204669000961 sequence specific DNA binding site [nucleotide binding]; other site 204669000962 putative cAMP binding site [chemical binding]; other site 204669000963 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 204669000964 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 204669000965 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 204669000966 Hemerythrin-like domain; Region: Hr-like; cd12108 204669000967 Fe binding site [ion binding]; other site 204669000968 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 204669000969 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669000970 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 204669000971 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 204669000972 Walker A/P-loop; other site 204669000973 ATP binding site [chemical binding]; other site 204669000974 Q-loop/lid; other site 204669000975 ABC transporter signature motif; other site 204669000976 Walker B; other site 204669000977 D-loop; other site 204669000978 H-loop/switch region; other site 204669000979 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669000980 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000981 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000982 FtsX-like permease family; Region: FtsX; pfam02687 204669000983 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669000984 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000985 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000986 FtsX-like permease family; Region: FtsX; pfam02687 204669000987 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669000988 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000989 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000990 FtsX-like permease family; Region: FtsX; pfam02687 204669000991 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669000992 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000993 FtsX-like permease family; Region: FtsX; pfam02687 204669000994 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669000995 FtsX-like permease family; Region: FtsX; pfam02687 204669000996 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 204669000997 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 204669000998 Walker A/P-loop; other site 204669000999 ATP binding site [chemical binding]; other site 204669001000 Q-loop/lid; other site 204669001001 ABC transporter signature motif; other site 204669001002 Walker B; other site 204669001003 D-loop; other site 204669001004 H-loop/switch region; other site 204669001005 Outer membrane efflux protein; Region: OEP; pfam02321 204669001006 Outer membrane efflux protein; Region: OEP; pfam02321 204669001007 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669001008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669001009 active site 204669001010 phosphorylation site [posttranslational modification] 204669001011 intermolecular recognition site; other site 204669001012 dimerization interface [polypeptide binding]; other site 204669001013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669001014 Walker A motif; other site 204669001015 ATP binding site [chemical binding]; other site 204669001016 Walker B motif; other site 204669001017 arginine finger; other site 204669001018 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669001019 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 204669001020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669001021 ATP binding site [chemical binding]; other site 204669001022 Mg2+ binding site [ion binding]; other site 204669001023 G-X-G motif; other site 204669001024 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 204669001025 Protein of unknown function, DUF608; Region: DUF608; pfam04685 204669001026 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 204669001027 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 204669001028 NAD(P) binding site [chemical binding]; other site 204669001029 catalytic residues [active] 204669001030 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 204669001031 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 204669001032 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 204669001033 putative catalytic cysteine [active] 204669001034 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 204669001035 active site 204669001036 NAD binding site [chemical binding]; other site 204669001037 metal binding site [ion binding]; metal-binding site 204669001038 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 204669001039 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 204669001040 putative DNA binding site [nucleotide binding]; other site 204669001041 catalytic residue [active] 204669001042 putative H2TH interface [polypeptide binding]; other site 204669001043 putative catalytic residues [active] 204669001044 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 204669001045 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 204669001046 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 204669001047 synthetase active site [active] 204669001048 NTP binding site [chemical binding]; other site 204669001049 metal binding site [ion binding]; metal-binding site 204669001050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 204669001051 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 204669001052 ATP binding site [chemical binding]; other site 204669001053 putative Mg++ binding site [ion binding]; other site 204669001054 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 204669001055 nucleotide binding region [chemical binding]; other site 204669001056 ATP-binding site [chemical binding]; other site 204669001057 DEAD/H associated; Region: DEAD_assoc; pfam08494 204669001058 Family description; Region: VCBS; pfam13517 204669001059 Family description; Region: VCBS; pfam13517 204669001060 Family description; Region: VCBS; pfam13517 204669001061 Family description; Region: VCBS; pfam13517 204669001062 Family description; Region: VCBS; pfam13517 204669001063 Family description; Region: VCBS; pfam13517 204669001064 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 204669001065 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 204669001066 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 204669001067 putative active site [active] 204669001068 putative catalytic site [active] 204669001069 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 204669001070 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 204669001071 heterodimer interface [polypeptide binding]; other site 204669001072 active site 204669001073 FMN binding site [chemical binding]; other site 204669001074 homodimer interface [polypeptide binding]; other site 204669001075 substrate binding site [chemical binding]; other site 204669001076 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 204669001077 seryl-tRNA synthetase; Provisional; Region: PRK05431 204669001078 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 204669001079 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 204669001080 dimer interface [polypeptide binding]; other site 204669001081 active site 204669001082 motif 1; other site 204669001083 motif 2; other site 204669001084 motif 3; other site 204669001085 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 204669001086 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669001087 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 204669001088 GH18 domain of an uncharacterized family of bacterial proteins, which share a common three-domain architecture: an N-terminal glycosyl hydrolase family 18 (GH18) domain, a glycosyl transferase family 2 domain, and a C-terminal polysaccharide deacetylase...; Region: GH18_trifunctional; cd06549 204669001089 putative active site [active] 204669001090 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 204669001091 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 204669001092 NodB motif; other site 204669001093 putative active site [active] 204669001094 putative catalytic site [active] 204669001095 putative Zn binding site [ion binding]; other site 204669001096 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 204669001097 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 204669001098 DXD motif; other site 204669001099 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 204669001100 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669001101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669001102 active site 204669001103 phosphorylation site [posttranslational modification] 204669001104 intermolecular recognition site; other site 204669001105 dimerization interface [polypeptide binding]; other site 204669001106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669001107 Response regulator receiver domain; Region: Response_reg; pfam00072 204669001108 active site 204669001109 phosphorylation site [posttranslational modification] 204669001110 intermolecular recognition site; other site 204669001111 dimerization interface [polypeptide binding]; other site 204669001112 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 204669001113 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 204669001114 Glutamate binding site [chemical binding]; other site 204669001115 homodimer interface [polypeptide binding]; other site 204669001116 NAD binding site [chemical binding]; other site 204669001117 catalytic residues [active] 204669001118 Response regulator receiver domain; Region: Response_reg; pfam00072 204669001119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669001120 active site 204669001121 phosphorylation site [posttranslational modification] 204669001122 intermolecular recognition site; other site 204669001123 dimerization interface [polypeptide binding]; other site 204669001124 Ion channel; Region: Ion_trans_2; pfam07885 204669001125 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 204669001126 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 204669001127 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669001128 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669001129 DNA binding residues [nucleotide binding] 204669001130 dimerization interface [polypeptide binding]; other site 204669001131 PilZ domain; Region: PilZ; pfam07238 204669001132 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 204669001133 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 204669001134 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 204669001135 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669001136 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669001137 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 204669001138 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669001139 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 204669001140 HI0933-like protein; Region: HI0933_like; pfam03486 204669001141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 204669001142 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 204669001143 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 204669001144 Acid Phosphatase; Region: Acid_PPase; cl17256 204669001145 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669001146 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 204669001147 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669001148 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669001149 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669001150 FtsX-like permease family; Region: FtsX; pfam02687 204669001151 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669001152 FtsX-like permease family; Region: FtsX; pfam02687 204669001153 Histidine kinase; Region: His_kinase; pfam06580 204669001154 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 204669001155 ATP binding site [chemical binding]; other site 204669001156 Mg2+ binding site [ion binding]; other site 204669001157 G-X-G motif; other site 204669001158 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 204669001159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669001160 active site 204669001161 phosphorylation site [posttranslational modification] 204669001162 intermolecular recognition site; other site 204669001163 dimerization interface [polypeptide binding]; other site 204669001164 LytTr DNA-binding domain; Region: LytTR; smart00850 204669001165 LytTr DNA-binding domain; Region: LytTR; smart00850 204669001166 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 204669001167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 204669001168 DNA-binding site [nucleotide binding]; DNA binding site 204669001169 UTRA domain; Region: UTRA; pfam07702 204669001170 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669001171 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669001172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669001173 TPR motif; other site 204669001174 TPR repeat; Region: TPR_11; pfam13414 204669001175 binding surface 204669001176 TPR repeat; Region: TPR_11; pfam13414 204669001177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669001178 TPR motif; other site 204669001179 binding surface 204669001180 Family description; Region: VCBS; pfam13517 204669001181 Family description; Region: VCBS; pfam13517 204669001182 Family description; Region: VCBS; pfam13517 204669001183 Family description; Region: VCBS; pfam13517 204669001184 Family description; Region: VCBS; pfam13517 204669001185 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 204669001186 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 204669001187 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 204669001188 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669001189 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669001190 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 204669001191 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 204669001192 sugar binding site [chemical binding]; other site 204669001193 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669001194 Cytochrome c; Region: Cytochrom_C; pfam00034 204669001195 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669001196 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 204669001197 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 204669001198 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 204669001199 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 204669001200 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 204669001201 Subunit I/III interface [polypeptide binding]; other site 204669001202 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 204669001203 Subunit I/III interface [polypeptide binding]; other site 204669001204 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 204669001205 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 204669001206 DNA binding site [nucleotide binding] 204669001207 domain linker motif; other site 204669001208 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 204669001209 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 204669001210 ligand binding site [chemical binding]; other site 204669001211 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669001212 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669001213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669001214 binding surface 204669001215 TPR motif; other site 204669001216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669001217 binding surface 204669001218 TPR motif; other site 204669001219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669001220 TPR motif; other site 204669001221 binding surface 204669001222 TPR repeat; Region: TPR_11; pfam13414 204669001223 TPR repeat; Region: TPR_11; pfam13414 204669001224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669001225 binding surface 204669001226 TPR motif; other site 204669001227 TPR repeat; Region: TPR_11; pfam13414 204669001228 TPR repeat; Region: TPR_11; pfam13414 204669001229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 204669001230 Outer membrane efflux protein; Region: OEP; pfam02321 204669001231 Outer membrane efflux protein; Region: OEP; pfam02321 204669001232 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 204669001233 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669001234 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 204669001235 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 204669001236 peptidase domain interface [polypeptide binding]; other site 204669001237 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 204669001238 active site 204669001239 catalytic triad [active] 204669001240 calcium binding site [ion binding]; other site 204669001241 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 204669001242 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 204669001243 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 204669001244 molybdopterin cofactor binding site; other site 204669001245 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 204669001246 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 204669001247 molybdopterin cofactor binding site; other site 204669001248 4Fe-4S binding domain; Region: Fer4; cl02805 204669001249 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 204669001250 4Fe-4S binding domain; Region: Fer4_6; pfam12837 204669001251 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 204669001252 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 204669001253 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 204669001254 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 204669001255 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 204669001256 trimer interface; other site 204669001257 sugar binding site [chemical binding]; other site 204669001258 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 204669001259 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 204669001260 putative DNA binding site [nucleotide binding]; other site 204669001261 putative Zn2+ binding site [ion binding]; other site 204669001262 AsnC family; Region: AsnC_trans_reg; pfam01037 204669001263 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 204669001264 peptidase domain interface [polypeptide binding]; other site 204669001265 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 204669001266 active site 204669001267 catalytic triad [active] 204669001268 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 204669001269 catalytic residues [active] 204669001270 Family description; Region: VCBS; pfam13517 204669001271 Family description; Region: VCBS; pfam13517 204669001272 Family description; Region: VCBS; pfam13517 204669001273 Family description; Region: VCBS; pfam13517 204669001274 Family description; Region: VCBS; pfam13517 204669001275 Family description; Region: VCBS; pfam13517 204669001276 Family description; Region: VCBS; pfam13517 204669001277 Family description; Region: VCBS; pfam13517 204669001278 Family description; Region: VCBS; pfam13517 204669001279 Family description; Region: VCBS; pfam13517 204669001280 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 204669001281 4Fe-4S binding domain; Region: Fer4; cl02805 204669001282 Cysteine-rich domain; Region: CCG; pfam02754 204669001283 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 204669001284 Ligand binding site [chemical binding]; other site 204669001285 Electron transfer flavoprotein domain; Region: ETF; pfam01012 204669001286 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 204669001287 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 204669001288 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 204669001289 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 204669001290 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 204669001291 active site 204669001292 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 204669001293 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 204669001294 active site 204669001295 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 204669001296 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 204669001297 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 204669001298 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 204669001299 active site 204669001300 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 204669001301 putative NADP binding site [chemical binding]; other site 204669001302 active site 204669001303 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 204669001304 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 204669001305 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 204669001306 ATP-grasp domain; Region: ATP-grasp_4; cl17255 204669001307 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 204669001308 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 204669001309 carboxyltransferase (CT) interaction site; other site 204669001310 biotinylation site [posttranslational modification]; other site 204669001311 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 204669001312 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 204669001313 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 204669001314 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 204669001315 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 204669001316 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 204669001317 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 204669001318 FecR protein; Region: FecR; pfam04773 204669001319 CHASE2 domain; Region: CHASE2; pfam05226 204669001320 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 204669001321 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 204669001322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669001323 dimer interface [polypeptide binding]; other site 204669001324 phosphorylation site [posttranslational modification] 204669001325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669001326 ATP binding site [chemical binding]; other site 204669001327 Mg2+ binding site [ion binding]; other site 204669001328 G-X-G motif; other site 204669001329 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669001330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669001331 active site 204669001332 phosphorylation site [posttranslational modification] 204669001333 intermolecular recognition site; other site 204669001334 dimerization interface [polypeptide binding]; other site 204669001335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669001336 Walker A motif; other site 204669001337 ATP binding site [chemical binding]; other site 204669001338 Walker B motif; other site 204669001339 arginine finger; other site 204669001340 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669001341 4Fe-4S binding domain; Region: Fer4_2; pfam12797 204669001342 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 204669001343 4Fe-4S binding domain; Region: Fer4; pfam00037 204669001344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 204669001345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 204669001346 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 204669001347 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 204669001348 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 204669001349 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 204669001350 catalytic loop [active] 204669001351 iron binding site [ion binding]; other site 204669001352 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 204669001353 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 204669001354 nucleotide binding site [chemical binding]; other site 204669001355 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 204669001356 HSP70 interaction site [polypeptide binding]; other site 204669001357 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 204669001358 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 204669001359 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 204669001360 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 204669001361 trimerization site [polypeptide binding]; other site 204669001362 active site 204669001363 cysteine desulfurase; Provisional; Region: PRK14012 204669001364 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 204669001365 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 204669001366 catalytic residue [active] 204669001367 Rrf2 family protein; Region: rrf2_super; TIGR00738 204669001368 Transcriptional regulator; Region: Rrf2; pfam02082 204669001369 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669001370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669001371 active site 204669001372 phosphorylation site [posttranslational modification] 204669001373 intermolecular recognition site; other site 204669001374 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 204669001375 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 204669001376 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669001377 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669001378 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669001379 DoxX; Region: DoxX; pfam07681 204669001380 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 204669001381 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 204669001382 UGMP family protein; Validated; Region: PRK09604 204669001383 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 204669001384 cardiolipin synthase 2; Provisional; Region: PRK11263 204669001385 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 204669001386 putative active site [active] 204669001387 catalytic site [active] 204669001388 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 204669001389 putative active site [active] 204669001390 catalytic site [active] 204669001391 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 204669001392 putative catalytic site [active] 204669001393 putative metal binding site [ion binding]; other site 204669001394 putative phosphate binding site [ion binding]; other site 204669001395 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 204669001396 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 204669001397 active site 204669001398 NTP binding site [chemical binding]; other site 204669001399 metal binding triad [ion binding]; metal-binding site 204669001400 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 204669001401 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669001402 Zn2+ binding site [ion binding]; other site 204669001403 Mg2+ binding site [ion binding]; other site 204669001404 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 204669001405 Protein of unknown function (DUF721); Region: DUF721; pfam05258 204669001406 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 204669001407 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 204669001408 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 204669001409 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 204669001410 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 204669001411 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 204669001412 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 204669001413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669001414 active site 204669001415 phosphorylation site [posttranslational modification] 204669001416 intermolecular recognition site; other site 204669001417 dimerization interface [polypeptide binding]; other site 204669001418 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669001419 Zn2+ binding site [ion binding]; other site 204669001420 Mg2+ binding site [ion binding]; other site 204669001421 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 204669001422 Ligand binding site; other site 204669001423 Ligand binding site; other site 204669001424 Ligand binding site; other site 204669001425 Putative Catalytic site; other site 204669001426 DXD motif; other site 204669001427 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 204669001428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669001429 dimer interface [polypeptide binding]; other site 204669001430 phosphorylation site [posttranslational modification] 204669001431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669001432 ATP binding site [chemical binding]; other site 204669001433 Mg2+ binding site [ion binding]; other site 204669001434 G-X-G motif; other site 204669001435 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 204669001436 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 204669001437 Ligand Binding Site [chemical binding]; other site 204669001438 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669001439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669001440 active site 204669001441 phosphorylation site [posttranslational modification] 204669001442 intermolecular recognition site; other site 204669001443 dimerization interface [polypeptide binding]; other site 204669001444 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669001445 DNA binding site [nucleotide binding] 204669001446 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 204669001447 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 204669001448 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 204669001449 Soluble P-type ATPase [General function prediction only]; Region: COG4087 204669001450 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 204669001451 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 204669001452 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 204669001453 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 204669001454 Asp-box motif; other site 204669001455 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 204669001456 Syntaxin; Region: Syntaxin; pfam00804 204669001457 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 204669001458 Recombinase; Region: Recombinase; pfam07508 204669001459 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 204669001460 Intermediate filament protein; Region: Filament; pfam00038 204669001461 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669001462 dimerization interface [polypeptide binding]; other site 204669001463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669001464 dimer interface [polypeptide binding]; other site 204669001465 phosphorylation site [posttranslational modification] 204669001466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669001467 ATP binding site [chemical binding]; other site 204669001468 Mg2+ binding site [ion binding]; other site 204669001469 G-X-G motif; other site 204669001470 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669001471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669001472 active site 204669001473 phosphorylation site [posttranslational modification] 204669001474 intermolecular recognition site; other site 204669001475 dimerization interface [polypeptide binding]; other site 204669001476 PilZ domain; Region: PilZ; pfam07238 204669001477 PilZ domain; Region: PilZ; pfam07238 204669001478 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 204669001479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669001480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669001481 DNA binding residues [nucleotide binding] 204669001482 hypothetical protein; Provisional; Region: PRK05409 204669001483 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 204669001484 Predicted membrane protein [Function unknown]; Region: COG2259 204669001485 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 204669001486 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 204669001487 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 204669001488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 204669001489 Putative glucoamylase; Region: Glycoamylase; pfam10091 204669001490 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669001491 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669001492 Transcriptional regulators [Transcription]; Region: PurR; COG1609 204669001493 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 204669001494 DNA binding site [nucleotide binding] 204669001495 domain linker motif; other site 204669001496 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 204669001497 ligand binding site [chemical binding]; other site 204669001498 dimerization interface [polypeptide binding]; other site 204669001499 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 204669001500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669001501 putative substrate translocation pore; other site 204669001502 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 204669001503 active site 204669001504 substrate-binding site [chemical binding]; other site 204669001505 metal-binding site [ion binding] 204669001506 GTP binding site [chemical binding]; other site 204669001507 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 204669001508 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 204669001509 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 204669001510 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 204669001511 Putative zinc-finger; Region: zf-HC2; pfam13490 204669001512 putative anti-sigmaE protein; Provisional; Region: PRK13920 204669001513 Anti-sigma-K factor rskA; Region: RskA; pfam10099 204669001514 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 204669001515 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669001516 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669001517 DNA binding residues [nucleotide binding] 204669001518 Hemerythrin-like domain; Region: Hr-like; cd12108 204669001519 Fe binding site [ion binding]; other site 204669001520 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 204669001521 N-acetyl-D-glucosamine binding site [chemical binding]; other site 204669001522 catalytic residue [active] 204669001523 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 204669001524 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 204669001525 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 204669001526 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 204669001527 ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha...; Region: ASRGL1_like; cd04702 204669001528 catalytic nucleophile [active] 204669001529 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 204669001530 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 204669001531 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 204669001532 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 204669001533 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 204669001534 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 204669001535 Domain of unknown function DUF20; Region: UPF0118; pfam01594 204669001536 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 204669001537 YceG-like family; Region: YceG; pfam02618 204669001538 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 204669001539 dimerization interface [polypeptide binding]; other site 204669001540 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 204669001541 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669001542 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 204669001543 FtsX-like permease family; Region: FtsX; pfam02687 204669001544 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669001545 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 204669001546 23S rRNA interface [nucleotide binding]; other site 204669001547 L3 interface [polypeptide binding]; other site 204669001548 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 204669001549 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 204669001550 rRNA interaction site [nucleotide binding]; other site 204669001551 S8 interaction site; other site 204669001552 putative laminin-1 binding site; other site 204669001553 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 204669001554 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669001555 active site 204669001556 elongation factor Ts; Reviewed; Region: tsf; PRK12332 204669001557 UBA/TS-N domain; Region: UBA; pfam00627 204669001558 Elongation factor TS; Region: EF_TS; pfam00889 204669001559 Domain of unknown function DUF20; Region: UPF0118; pfam01594 204669001560 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 204669001561 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 204669001562 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 204669001563 active site 204669001564 (T/H)XGH motif; other site 204669001565 aspartate aminotransferase; Provisional; Region: PRK05764 204669001566 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 204669001567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669001568 homodimer interface [polypeptide binding]; other site 204669001569 catalytic residue [active] 204669001570 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 204669001571 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 204669001572 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 204669001573 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 204669001574 Substrate binding site; other site 204669001575 Cupin domain; Region: Cupin_2; cl17218 204669001576 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 204669001577 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 204669001578 active site 204669001579 substrate binding site [chemical binding]; other site 204669001580 metal binding site [ion binding]; metal-binding site 204669001581 Peptidase family M48; Region: Peptidase_M48; pfam01435 204669001582 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 204669001583 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 204669001584 Ligand binding site; other site 204669001585 oligomer interface; other site 204669001586 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 204669001587 asparagine synthetase AsnA; Provisional; Region: PRK05425 204669001588 motif 1; other site 204669001589 dimer interface [polypeptide binding]; other site 204669001590 active site 204669001591 motif 2; other site 204669001592 motif 3; other site 204669001593 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 204669001594 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 204669001595 active site 204669001596 catalytic tetrad [active] 204669001597 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 204669001598 active site 204669001599 beta-D-glucuronidase; Provisional; Region: PRK10150 204669001600 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 204669001601 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 204669001602 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 204669001603 LexA repressor; Validated; Region: PRK00215 204669001604 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 204669001605 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 204669001606 Catalytic site [active] 204669001607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669001608 binding surface 204669001609 TPR motif; other site 204669001610 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669001611 GAF domain; Region: GAF; pfam01590 204669001612 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 204669001613 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 204669001614 metal binding site [ion binding]; metal-binding site 204669001615 active site 204669001616 I-site; other site 204669001617 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 204669001618 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 204669001619 catalytic loop [active] 204669001620 iron binding site [ion binding]; other site 204669001621 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 204669001622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669001623 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669001624 DNA binding residues [nucleotide binding] 204669001625 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 204669001626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669001627 binding surface 204669001628 TPR motif; other site 204669001629 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 204669001630 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 204669001631 ligand binding site [chemical binding]; other site 204669001632 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 204669001633 TolB amino-terminal domain; Region: TolB_N; pfam04052 204669001634 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669001635 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669001636 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669001637 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669001638 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 204669001639 TonB C terminal; Region: TonB_2; pfam13103 204669001640 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 204669001641 TolR protein; Region: tolR; TIGR02801 204669001642 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 204669001643 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 204669001644 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 204669001645 Walker A/P-loop; other site 204669001646 ATP binding site [chemical binding]; other site 204669001647 Q-loop/lid; other site 204669001648 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 204669001649 ABC transporter signature motif; other site 204669001650 Walker B; other site 204669001651 D-loop; other site 204669001652 H-loop/switch region; other site 204669001653 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 204669001654 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 204669001655 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 204669001656 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 204669001657 dimer interface [polypeptide binding]; other site 204669001658 PYR/PP interface [polypeptide binding]; other site 204669001659 TPP binding site [chemical binding]; other site 204669001660 substrate binding site [chemical binding]; other site 204669001661 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 204669001662 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 204669001663 TPP-binding site [chemical binding]; other site 204669001664 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 204669001665 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 204669001666 30S subunit binding site; other site 204669001667 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 204669001668 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 204669001669 DNA binding residues [nucleotide binding] 204669001670 peptide chain release factor 1; Provisional; Region: PRK04011 204669001671 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 204669001672 active site 204669001673 dimer interface [polypeptide binding]; other site 204669001674 catalytic nucleophile [active] 204669001675 MarC family integral membrane protein; Region: MarC; pfam01914 204669001676 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669001677 Catalytic domain of Protein Kinases; Region: PKc; cd00180 204669001678 active site 204669001679 ATP binding site [chemical binding]; other site 204669001680 substrate binding site [chemical binding]; other site 204669001681 activation loop (A-loop); other site 204669001682 Predicted integral membrane protein [Function unknown]; Region: COG5616 204669001683 TPR repeat; Region: TPR_11; pfam13414 204669001684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669001685 binding surface 204669001686 TPR motif; other site 204669001687 TPR repeat; Region: TPR_11; pfam13414 204669001688 TPR repeat; Region: TPR_11; pfam13414 204669001689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669001690 binding surface 204669001691 TPR motif; other site 204669001692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669001693 binding surface 204669001694 TPR repeat; Region: TPR_11; pfam13414 204669001695 TPR motif; other site 204669001696 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 204669001697 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 204669001698 Peptidase family M48; Region: Peptidase_M48; cl12018 204669001699 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 204669001700 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 204669001701 putative active site [active] 204669001702 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 204669001703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 204669001704 active site 204669001705 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 204669001706 Beta-lactamase; Region: Beta-lactamase; pfam00144 204669001707 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 204669001708 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 204669001709 active site 204669001710 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 204669001711 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669001712 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669001713 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669001714 FtsX-like permease family; Region: FtsX; pfam02687 204669001715 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669001716 FtsX-like permease family; Region: FtsX; pfam02687 204669001717 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 204669001718 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669001719 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669001720 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669001721 FtsX-like permease family; Region: FtsX; pfam02687 204669001722 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669001723 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669001724 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669001725 FtsX-like permease family; Region: FtsX; pfam02687 204669001726 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669001727 FtsX-like permease family; Region: FtsX; pfam02687 204669001728 Salivary protein of 15kDa inhibits CD4+ T cell activation; Region: Salp15; pfam12115 204669001729 Radical SAM superfamily; Region: Radical_SAM; pfam04055 204669001730 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669001731 FeS/SAM binding site; other site 204669001732 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 204669001733 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 204669001734 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 204669001735 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 204669001736 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 204669001737 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 204669001738 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 204669001739 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 204669001740 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 204669001741 TIGR01777 family protein; Region: yfcH 204669001742 putative NAD(P) binding site [chemical binding]; other site 204669001743 putative active site [active] 204669001744 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669001745 acetylornithine aminotransferase; Provisional; Region: PRK02627 204669001746 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 204669001747 inhibitor-cofactor binding pocket; inhibition site 204669001748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669001749 catalytic residue [active] 204669001750 Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083 204669001751 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 204669001752 TAP-like protein; Region: Abhydrolase_4; pfam08386 204669001753 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 204669001754 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 204669001755 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 204669001756 Protein of unknown function DUF58; Region: DUF58; pfam01882 204669001757 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 204669001758 FOG: CBS domain [General function prediction only]; Region: COG0517 204669001759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 204669001760 dimerization interface [polypeptide binding]; other site 204669001761 putative DNA binding site [nucleotide binding]; other site 204669001762 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 204669001763 putative Zn2+ binding site [ion binding]; other site 204669001764 AsnC family; Region: AsnC_trans_reg; pfam01037 204669001765 DsrC like protein; Region: DsrC; pfam04358 204669001766 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 204669001767 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 204669001768 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 204669001769 catalytic residue [active] 204669001770 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 204669001771 Beta-lactamase; Region: Beta-lactamase; pfam00144 204669001772 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669001773 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669001774 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669001775 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 204669001776 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 204669001777 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 204669001778 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 204669001779 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669001780 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 204669001781 active site 204669001782 catalytic residues [active] 204669001783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669001784 short chain dehydrogenase; Provisional; Region: PRK06138 204669001785 NAD(P) binding site [chemical binding]; other site 204669001786 active site 204669001787 aldose dehydrogenase; Validated; Region: PRK06398 204669001788 classical (c) SDRs; Region: SDR_c; cd05233 204669001789 NAD(P) binding site [chemical binding]; other site 204669001790 active site 204669001791 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 204669001792 Ca binding site [ion binding]; other site 204669001793 substrate binding site [chemical binding]; other site 204669001794 N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791 204669001795 putative active site [active] 204669001796 catalytic site [active] 204669001797 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 204669001798 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 204669001799 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 204669001800 metal binding site [ion binding]; metal-binding site 204669001801 substrate binding pocket [chemical binding]; other site 204669001802 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 204669001803 Strictosidine synthase; Region: Str_synth; pfam03088 204669001804 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 204669001805 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 204669001806 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 204669001807 S-formylglutathione hydrolase; Region: PLN02442 204669001808 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 204669001809 putative alpha-glucosidase; Provisional; Region: PRK10658 204669001810 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 204669001811 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 204669001812 trimer interface [polypeptide binding]; other site 204669001813 active site 204669001814 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 204669001815 catalytic site [active] 204669001816 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 204669001817 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 204669001818 nucleotide binding site [chemical binding]; other site 204669001819 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 204669001820 glucose-6-phosphate isomerase; Provisional; Region: PRK04190 204669001821 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 204669001822 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 204669001823 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 204669001824 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 204669001825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669001826 putative substrate translocation pore; other site 204669001827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669001828 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 204669001829 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 204669001830 DNA-binding site [nucleotide binding]; DNA binding site 204669001831 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 204669001832 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669001833 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669001834 ligand binding site [chemical binding]; other site 204669001835 flexible hinge region; other site 204669001836 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 204669001837 Amidohydrolase; Region: Amidohydro_2; pfam04909 204669001838 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 204669001839 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 204669001840 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 204669001841 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 204669001842 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 204669001843 substrate binding site [chemical binding]; other site 204669001844 ATP binding site [chemical binding]; other site 204669001845 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 204669001846 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 204669001847 putative substrate binding site [chemical binding]; other site 204669001848 putative ATP binding site [chemical binding]; other site 204669001849 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 204669001850 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669001851 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669001852 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 204669001853 catalytic site [active] 204669001854 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 204669001855 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 204669001856 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 204669001857 putative active site [active] 204669001858 MASE1; Region: MASE1; pfam05231 204669001859 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 204669001860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669001861 putative active site [active] 204669001862 heme pocket [chemical binding]; other site 204669001863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669001864 dimer interface [polypeptide binding]; other site 204669001865 phosphorylation site [posttranslational modification] 204669001866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669001867 ATP binding site [chemical binding]; other site 204669001868 Mg2+ binding site [ion binding]; other site 204669001869 G-X-G motif; other site 204669001870 Response regulator receiver domain; Region: Response_reg; pfam00072 204669001871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669001872 active site 204669001873 phosphorylation site [posttranslational modification] 204669001874 intermolecular recognition site; other site 204669001875 dimerization interface [polypeptide binding]; other site 204669001876 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 204669001877 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 204669001878 acyl-activating enzyme (AAE) consensus motif; other site 204669001879 putative AMP binding site [chemical binding]; other site 204669001880 putative active site [active] 204669001881 putative CoA binding site [chemical binding]; other site 204669001882 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 204669001883 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 204669001884 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 204669001885 catalytic residue [active] 204669001886 Isochorismatase family; Region: Isochorismatase; pfam00857 204669001887 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 204669001888 catalytic triad [active] 204669001889 dimer interface [polypeptide binding]; other site 204669001890 conserved cis-peptide bond; other site 204669001891 Methyltransferase domain; Region: Methyltransf_31; pfam13847 204669001892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669001893 S-adenosylmethionine binding site [chemical binding]; other site 204669001894 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669001895 amino acid transporter; Region: 2A0306; TIGR00909 204669001896 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 204669001897 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669001898 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 204669001899 kynureninase; Region: kynureninase; TIGR01814 204669001900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 204669001901 catalytic residue [active] 204669001902 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 204669001903 FAD binding domain; Region: FAD_binding_3; pfam01494 204669001904 Amidohydrolase; Region: Amidohydro_2; pfam04909 204669001905 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 204669001906 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 204669001907 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 204669001908 homotrimer interaction site [polypeptide binding]; other site 204669001909 putative active site [active] 204669001910 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 204669001911 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 204669001912 NAD binding site [chemical binding]; other site 204669001913 catalytic residues [active] 204669001914 putative hydrolase; Provisional; Region: PRK11460 204669001915 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 204669001916 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 204669001917 Double zinc ribbon; Region: DZR; pfam12773 204669001918 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 204669001919 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 204669001920 threonine dehydratase; Provisional; Region: PRK08198 204669001921 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 204669001922 tetramer interface [polypeptide binding]; other site 204669001923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669001924 catalytic residue [active] 204669001925 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 204669001926 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 204669001927 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 204669001928 Walker A motif; other site 204669001929 ATP binding site [chemical binding]; other site 204669001930 Walker B motif; other site 204669001931 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669001932 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669001933 PAS domain S-box; Region: sensory_box; TIGR00229 204669001934 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669001935 putative active site [active] 204669001936 heme pocket [chemical binding]; other site 204669001937 PAS domain S-box; Region: sensory_box; TIGR00229 204669001938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669001939 putative active site [active] 204669001940 heme pocket [chemical binding]; other site 204669001941 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669001942 putative active site [active] 204669001943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669001944 heme pocket [chemical binding]; other site 204669001945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669001946 ATP binding site [chemical binding]; other site 204669001947 Mg2+ binding site [ion binding]; other site 204669001948 G-X-G motif; other site 204669001949 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 204669001950 substrate binding site [chemical binding]; other site 204669001951 active site 204669001952 Ferrochelatase; Region: Ferrochelatase; pfam00762 204669001953 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 204669001954 C-terminal domain interface [polypeptide binding]; other site 204669001955 active site 204669001956 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 204669001957 active site 204669001958 N-terminal domain interface [polypeptide binding]; other site 204669001959 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 204669001960 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 204669001961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 204669001962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 204669001963 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 204669001964 endonuclease III; Region: ENDO3c; smart00478 204669001965 minor groove reading motif; other site 204669001966 helix-hairpin-helix signature motif; other site 204669001967 substrate binding pocket [chemical binding]; other site 204669001968 active site 204669001969 recombination regulator RecX; Reviewed; Region: recX; PRK00117 204669001970 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 204669001971 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 204669001972 ATP binding site [chemical binding]; other site 204669001973 Walker B motif; other site 204669001974 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669001975 von Willebrand factor type A domain; Region: VWA_2; pfam13519 204669001976 metal ion-dependent adhesion site (MIDAS); other site 204669001977 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669001978 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 204669001979 metal ion-dependent adhesion site (MIDAS); other site 204669001980 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 204669001981 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 204669001982 G1 box; other site 204669001983 GTP/Mg2+ binding site [chemical binding]; other site 204669001984 G2 box; other site 204669001985 Switch I region; other site 204669001986 G3 box; other site 204669001987 Switch II region; other site 204669001988 G4 box; other site 204669001989 G5 box; other site 204669001990 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 204669001991 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 204669001992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669001993 Walker A motif; other site 204669001994 ATP binding site [chemical binding]; other site 204669001995 Walker B motif; other site 204669001996 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 204669001997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669001998 PAS domain; Region: PAS_9; pfam13426 204669001999 putative active site [active] 204669002000 heme pocket [chemical binding]; other site 204669002001 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669002002 dimer interface [polypeptide binding]; other site 204669002003 phosphorylation site [posttranslational modification] 204669002004 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 204669002005 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 204669002006 homodimer interface [polypeptide binding]; other site 204669002007 substrate-cofactor binding pocket; other site 204669002008 catalytic residue [active] 204669002009 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 204669002010 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 204669002011 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 204669002012 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 204669002013 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 204669002014 23S rRNA binding site [nucleotide binding]; other site 204669002015 L21 binding site [polypeptide binding]; other site 204669002016 L13 binding site [polypeptide binding]; other site 204669002017 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 204669002018 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 204669002019 dimer interface [polypeptide binding]; other site 204669002020 motif 1; other site 204669002021 active site 204669002022 motif 2; other site 204669002023 motif 3; other site 204669002024 Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072 204669002025 B3/4 domain; Region: B3_4; pfam03483 204669002026 tRNA synthetase B5 domain; Region: B5; smart00874 204669002027 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 204669002028 dimer interface [polypeptide binding]; other site 204669002029 motif 1; other site 204669002030 motif 3; other site 204669002031 motif 2; other site 204669002032 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 204669002033 Cell division protein ZapA; Region: ZapA; pfam05164 204669002034 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669002035 FtsX-like permease family; Region: FtsX; pfam02687 204669002036 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669002037 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 204669002038 FtsX-like permease family; Region: FtsX; pfam02687 204669002039 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 204669002040 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 204669002041 ligand binding site; other site 204669002042 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 204669002043 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 204669002044 ligand binding site; other site 204669002045 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 204669002046 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 204669002047 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 204669002048 classical (c) SDRs; Region: SDR_c; cd05233 204669002049 NAD(P) binding site [chemical binding]; other site 204669002050 active site 204669002051 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 204669002052 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 204669002053 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 204669002054 putative active site [active] 204669002055 putative FMN binding site [chemical binding]; other site 204669002056 putative substrate binding site [chemical binding]; other site 204669002057 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 204669002058 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 204669002059 dimer interface [polypeptide binding]; other site 204669002060 PYR/PP interface [polypeptide binding]; other site 204669002061 TPP binding site [chemical binding]; other site 204669002062 substrate binding site [chemical binding]; other site 204669002063 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 204669002064 Domain of unknown function; Region: EKR; smart00890 204669002065 4Fe-4S binding domain; Region: Fer4_6; pfam12837 204669002066 4Fe-4S binding domain; Region: Fer4; pfam00037 204669002067 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 204669002068 TPP-binding site [chemical binding]; other site 204669002069 dimer interface [polypeptide binding]; other site 204669002070 Phosphoesterase family; Region: Phosphoesterase; pfam04185 204669002071 TPR repeat; Region: TPR_11; pfam13414 204669002072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002073 binding surface 204669002074 TPR motif; other site 204669002075 TPR repeat; Region: TPR_11; pfam13414 204669002076 Phosphopantetheine attachment site; Region: PP-binding; cl09936 204669002077 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 204669002078 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 204669002079 acyl-activating enzyme (AAE) consensus motif; other site 204669002080 active site 204669002081 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 204669002082 TPR repeat; Region: TPR_11; pfam13414 204669002083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002084 binding surface 204669002085 TPR motif; other site 204669002086 TPR repeat; Region: TPR_11; pfam13414 204669002087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002088 binding surface 204669002089 TPR motif; other site 204669002090 TPR repeat; Region: TPR_11; pfam13414 204669002091 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 204669002092 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 204669002093 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 204669002094 NHL repeat; Region: NHL; pfam01436 204669002095 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 204669002096 SurA N-terminal domain; Region: SurA_N_3; cl07813 204669002097 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 204669002098 Uncharacterized conserved protein [Function unknown]; Region: COG3391 204669002099 NHL repeat; Region: NHL; pfam01436 204669002100 NHL repeat; Region: NHL; pfam01436 204669002101 NHL repeat; Region: NHL; pfam01436 204669002102 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 204669002103 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 204669002104 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 204669002105 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 204669002106 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 204669002107 ResB-like family; Region: ResB; pfam05140 204669002108 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 204669002109 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 204669002110 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 204669002111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669002112 dimerization interface [polypeptide binding]; other site 204669002113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669002114 dimer interface [polypeptide binding]; other site 204669002115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669002116 ATP binding site [chemical binding]; other site 204669002117 Mg2+ binding site [ion binding]; other site 204669002118 G-X-G motif; other site 204669002119 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669002120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669002121 active site 204669002122 phosphorylation site [posttranslational modification] 204669002123 intermolecular recognition site; other site 204669002124 dimerization interface [polypeptide binding]; other site 204669002125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669002126 Walker A motif; other site 204669002127 ATP binding site [chemical binding]; other site 204669002128 Walker B motif; other site 204669002129 arginine finger; other site 204669002130 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669002131 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 204669002132 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 204669002133 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 204669002134 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 204669002135 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669002136 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669002137 FtsX-like permease family; Region: FtsX; pfam02687 204669002138 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669002139 FtsX-like permease family; Region: FtsX; pfam02687 204669002140 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669002141 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 204669002142 TPR repeat; Region: TPR_11; pfam13414 204669002143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002144 binding surface 204669002145 TPR motif; other site 204669002146 TPR repeat; Region: TPR_11; pfam13414 204669002147 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 204669002148 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 204669002149 tRNA; other site 204669002150 putative tRNA binding site [nucleotide binding]; other site 204669002151 putative NADP binding site [chemical binding]; other site 204669002152 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 204669002153 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669002154 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669002155 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 204669002156 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 204669002157 catalytic loop [active] 204669002158 iron binding site [ion binding]; other site 204669002159 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 204669002160 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 204669002161 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 204669002162 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 204669002163 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 204669002164 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 204669002165 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 204669002166 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 204669002167 lipoyl attachment site [posttranslational modification]; other site 204669002168 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 204669002169 TPR motif; other site 204669002170 binding surface 204669002171 EthD domain; Region: EthD; cl17553 204669002172 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669002173 Catalytic domain of Protein Kinases; Region: PKc; cd00180 204669002174 active site 204669002175 ATP binding site [chemical binding]; other site 204669002176 substrate binding site [chemical binding]; other site 204669002177 activation loop (A-loop); other site 204669002178 Predicted integral membrane protein [Function unknown]; Region: COG5616 204669002179 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 204669002180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002181 binding surface 204669002182 TPR motif; other site 204669002183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002184 binding surface 204669002185 TPR motif; other site 204669002186 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669002187 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 204669002188 metal ion-dependent adhesion site (MIDAS); other site 204669002189 SnoaL-like domain; Region: SnoaL_3; pfam13474 204669002190 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 204669002191 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669002192 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 204669002193 CAAX protease self-immunity; Region: Abi; pfam02517 204669002194 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 204669002195 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 204669002196 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 204669002197 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 204669002198 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 204669002199 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 204669002200 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 204669002201 active site 204669002202 DNA binding site [nucleotide binding] 204669002203 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 204669002204 DNA binding site [nucleotide binding] 204669002205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002206 binding surface 204669002207 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669002208 TPR motif; other site 204669002209 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669002210 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 204669002211 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 204669002212 active site 204669002213 catalytic tetrad [active] 204669002214 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669002215 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669002216 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669002217 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669002218 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669002219 Halocarboxylic acid dehydrogenase DehI; Region: DehI; pfam10778 204669002220 Halocarboxylic acid dehydrogenase DehI; Region: DehI; pfam10778 204669002221 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 204669002222 nucleotide binding site/active site [active] 204669002223 HIT family signature motif; other site 204669002224 catalytic residue [active] 204669002225 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 204669002226 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 204669002227 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 204669002228 Sporulation related domain; Region: SPOR; cl10051 204669002229 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 204669002230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669002231 FeS/SAM binding site; other site 204669002232 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669002233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669002234 DNA binding site [nucleotide binding] 204669002235 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 204669002236 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 204669002237 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 204669002238 short chain dehydrogenase; Validated; Region: PRK06182 204669002239 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 204669002240 NADP binding site [chemical binding]; other site 204669002241 active site 204669002242 steroid binding site; other site 204669002243 Methyltransferase domain; Region: Methyltransf_23; pfam13489 204669002244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669002245 S-adenosylmethionine binding site [chemical binding]; other site 204669002246 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 204669002247 substrate binding site [chemical binding]; other site 204669002248 putative active site [active] 204669002249 redox center [active] 204669002250 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 204669002251 Thioredoxin; Region: Thioredoxin_4; pfam13462 204669002252 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 204669002253 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 204669002254 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669002255 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 204669002256 reactive center loop; other site 204669002257 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 204669002258 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669002259 FeS/SAM binding site; other site 204669002260 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 204669002261 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 204669002262 minor groove reading motif; other site 204669002263 helix-hairpin-helix signature motif; other site 204669002264 substrate binding pocket [chemical binding]; other site 204669002265 active site 204669002266 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 204669002267 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 204669002268 nudix motif; other site 204669002269 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 204669002270 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 204669002271 catalytic residues [active] 204669002272 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 204669002273 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 204669002274 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 204669002275 PA/protease or protease-like domain interface [polypeptide binding]; other site 204669002276 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 204669002277 metal binding site [ion binding]; metal-binding site 204669002278 PBP superfamily domain; Region: PBP_like_2; cl17296 204669002279 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 204669002280 TPR repeat; Region: TPR_11; pfam13414 204669002281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002282 TPR motif; other site 204669002283 binding surface 204669002284 TPR repeat; Region: TPR_11; pfam13414 204669002285 cyclase homology domain; Region: CHD; cd07302 204669002286 nucleotidyl binding site; other site 204669002287 metal binding site [ion binding]; metal-binding site 204669002288 dimer interface [polypeptide binding]; other site 204669002289 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669002290 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 204669002291 putative hydrophobic ligand binding site [chemical binding]; other site 204669002292 Protein of unknown function DUF72; Region: DUF72; pfam01904 204669002293 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 204669002294 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 204669002295 diiron binding motif [ion binding]; other site 204669002296 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 204669002297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669002298 FeS/SAM binding site; other site 204669002299 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 204669002300 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 204669002301 putative ligand binding site [chemical binding]; other site 204669002302 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 204669002303 homodimer interface [polypeptide binding]; other site 204669002304 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 204669002305 active site pocket [active] 204669002306 PAS domain S-box; Region: sensory_box; TIGR00229 204669002307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669002308 putative active site [active] 204669002309 heme pocket [chemical binding]; other site 204669002310 PAS domain S-box; Region: sensory_box; TIGR00229 204669002311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669002312 putative active site [active] 204669002313 heme pocket [chemical binding]; other site 204669002314 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 204669002315 Histidine kinase; Region: HisKA_3; pfam07730 204669002316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669002317 ATP binding site [chemical binding]; other site 204669002318 Mg2+ binding site [ion binding]; other site 204669002319 G-X-G motif; other site 204669002320 Response regulator receiver domain; Region: Response_reg; pfam00072 204669002321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669002322 active site 204669002323 phosphorylation site [posttranslational modification] 204669002324 intermolecular recognition site; other site 204669002325 dimerization interface [polypeptide binding]; other site 204669002326 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 204669002327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002328 binding surface 204669002329 TPR motif; other site 204669002330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002331 TPR motif; other site 204669002332 binding surface 204669002333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002334 binding surface 204669002335 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669002336 TPR motif; other site 204669002337 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669002338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002339 binding surface 204669002340 TPR motif; other site 204669002341 Family description; Region: VCBS; pfam13517 204669002342 Family description; Region: VCBS; pfam13517 204669002343 Family description; Region: VCBS; pfam13517 204669002344 Family description; Region: VCBS; pfam13517 204669002345 Family description; Region: VCBS; pfam13517 204669002346 Family description; Region: VCBS; pfam13517 204669002347 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 204669002348 NMT1-like family; Region: NMT1_2; pfam13379 204669002349 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 204669002350 substrate binding pocket [chemical binding]; other site 204669002351 membrane-bound complex binding site; other site 204669002352 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 204669002353 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 204669002354 Walker A/P-loop; other site 204669002355 ATP binding site [chemical binding]; other site 204669002356 Q-loop/lid; other site 204669002357 ABC transporter signature motif; other site 204669002358 Walker B; other site 204669002359 D-loop; other site 204669002360 H-loop/switch region; other site 204669002361 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 204669002362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 204669002363 dimer interface [polypeptide binding]; other site 204669002364 conserved gate region; other site 204669002365 putative PBP binding loops; other site 204669002366 ABC-ATPase subunit interface; other site 204669002367 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 204669002368 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 204669002369 Active Sites [active] 204669002370 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 204669002371 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 204669002372 CysD dimerization site [polypeptide binding]; other site 204669002373 G1 box; other site 204669002374 putative GEF interaction site [polypeptide binding]; other site 204669002375 GTP/Mg2+ binding site [chemical binding]; other site 204669002376 Switch I region; other site 204669002377 G2 box; other site 204669002378 G3 box; other site 204669002379 Switch II region; other site 204669002380 G4 box; other site 204669002381 G5 box; other site 204669002382 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 204669002383 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 204669002384 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 204669002385 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 204669002386 Active Sites [active] 204669002387 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 204669002388 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 204669002389 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 204669002390 SLBB domain; Region: SLBB; pfam10531 204669002391 SLBB domain; Region: SLBB; pfam10531 204669002392 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 204669002393 Chain length determinant protein; Region: Wzz; pfam02706 204669002394 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 204669002395 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 204669002396 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 204669002397 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 204669002398 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 204669002399 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 204669002400 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669002401 mercuric reductase; Validated; Region: PRK06370 204669002402 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 204669002403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 204669002404 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 204669002405 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 204669002406 homotrimer interaction site [polypeptide binding]; other site 204669002407 putative active site [active] 204669002408 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 204669002409 GAF domain; Region: GAF_2; pfam13185 204669002410 GAF domain; Region: GAF_3; pfam13492 204669002411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669002412 PAS fold; Region: PAS_3; pfam08447 204669002413 putative active site [active] 204669002414 heme pocket [chemical binding]; other site 204669002415 PAS fold; Region: PAS_3; pfam08447 204669002416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669002417 putative active site [active] 204669002418 heme pocket [chemical binding]; other site 204669002419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669002420 dimer interface [polypeptide binding]; other site 204669002421 phosphorylation site [posttranslational modification] 204669002422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669002423 ATP binding site [chemical binding]; other site 204669002424 Mg2+ binding site [ion binding]; other site 204669002425 G-X-G motif; other site 204669002426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669002427 Response regulator receiver domain; Region: Response_reg; pfam00072 204669002428 active site 204669002429 phosphorylation site [posttranslational modification] 204669002430 intermolecular recognition site; other site 204669002431 dimerization interface [polypeptide binding]; other site 204669002432 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 204669002433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669002434 active site 204669002435 phosphorylation site [posttranslational modification] 204669002436 intermolecular recognition site; other site 204669002437 dimerization interface [polypeptide binding]; other site 204669002438 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 204669002439 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 204669002440 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 204669002441 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 204669002442 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 204669002443 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 204669002444 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 204669002445 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 204669002446 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 204669002447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669002448 Walker A motif; other site 204669002449 ATP binding site [chemical binding]; other site 204669002450 Walker B motif; other site 204669002451 arginine finger; other site 204669002452 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 204669002453 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 204669002454 tail sheath protein; Provisional; Region: 18; PHA02539 204669002455 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 204669002456 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 204669002457 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 204669002458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669002459 Walker A motif; other site 204669002460 ATP binding site [chemical binding]; other site 204669002461 Walker B motif; other site 204669002462 arginine finger; other site 204669002463 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 204669002464 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 204669002465 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 204669002466 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 204669002467 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 204669002468 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 204669002469 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 204669002470 active site 204669002471 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 204669002472 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 204669002473 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669002474 FeS/SAM binding site; other site 204669002475 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 204669002476 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 204669002477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669002478 FeS/SAM binding site; other site 204669002479 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 204669002480 B12 binding site [chemical binding]; other site 204669002481 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 204669002482 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669002483 FeS/SAM binding site; other site 204669002484 B12 binding domain; Region: B12-binding; pfam02310 204669002485 B12 binding site [chemical binding]; other site 204669002486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669002487 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 204669002488 FeS/SAM binding site; other site 204669002489 Methyltransferase domain; Region: Methyltransf_31; pfam13847 204669002490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669002491 S-adenosylmethionine binding site [chemical binding]; other site 204669002492 Methyltransferase domain; Region: Methyltransf_31; pfam13847 204669002493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669002494 S-adenosylmethionine binding site [chemical binding]; other site 204669002495 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 204669002496 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 204669002497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669002498 FeS/SAM binding site; other site 204669002499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669002500 S-adenosylmethionine binding site [chemical binding]; other site 204669002501 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 204669002502 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669002503 active site 204669002504 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669002505 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 204669002506 FeS/SAM binding site; other site 204669002507 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 204669002508 Cytochrome c; Region: Cytochrom_C; cl11414 204669002509 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 204669002510 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669002511 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; Region: NGN_SP_TaA; cd09893 204669002512 transcriptional activator RfaH; Region: RfaH; TIGR01955 204669002513 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 204669002514 heterodimer interface [polypeptide binding]; other site 204669002515 homodimer interface [polypeptide binding]; other site 204669002516 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 204669002517 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 204669002518 SLBB domain; Region: SLBB; pfam10531 204669002519 SLBB domain; Region: SLBB; pfam10531 204669002520 SLBB domain; Region: SLBB; pfam10531 204669002521 SLBB domain; Region: SLBB; pfam10531 204669002522 Chain length determinant protein; Region: Wzz; cl15801 204669002523 NAD synthetase; Reviewed; Region: nadE; cl17435 204669002524 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 204669002525 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 204669002526 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 204669002527 O-Antigen ligase; Region: Wzy_C; pfam04932 204669002528 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 204669002529 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 204669002530 metal-binding site 204669002531 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 204669002532 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 204669002533 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 204669002534 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 204669002535 Arabidopsis thaliana GDP-mannose-3',5'-epimerase (GME)-like, extended (e) SDRs; Region: GME-like_SDR_e; cd05273 204669002536 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 204669002537 NAD binding site [chemical binding]; other site 204669002538 homodimer interface [polypeptide binding]; other site 204669002539 substrate binding site [chemical binding]; other site 204669002540 active site 204669002541 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 204669002542 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 204669002543 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 204669002544 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 204669002545 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 204669002546 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 204669002547 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 204669002548 putative active site [active] 204669002549 putative catalytic site [active] 204669002550 Transcriptional regulators [Transcription]; Region: PurR; COG1609 204669002551 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 204669002552 DNA binding site [nucleotide binding] 204669002553 domain linker motif; other site 204669002554 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 204669002555 ligand binding site [chemical binding]; other site 204669002556 dimerization interface [polypeptide binding]; other site 204669002557 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669002558 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 204669002559 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 204669002560 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 204669002561 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 204669002562 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 204669002563 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 204669002564 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 204669002565 xylose isomerase; Provisional; Region: PRK12677 204669002566 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 204669002567 N- and C-terminal domain interface [polypeptide binding]; other site 204669002568 D-xylulose kinase; Region: XylB; TIGR01312 204669002569 active site 204669002570 MgATP binding site [chemical binding]; other site 204669002571 catalytic site [active] 204669002572 metal binding site [ion binding]; metal-binding site 204669002573 xylulose binding site [chemical binding]; other site 204669002574 homodimer interface [polypeptide binding]; other site 204669002575 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 204669002576 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 204669002577 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 204669002578 TM-ABC transporter signature motif; other site 204669002579 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 204669002580 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 204669002581 Walker A/P-loop; other site 204669002582 ATP binding site [chemical binding]; other site 204669002583 Q-loop/lid; other site 204669002584 ABC transporter signature motif; other site 204669002585 Walker B; other site 204669002586 D-loop; other site 204669002587 H-loop/switch region; other site 204669002588 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 204669002589 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 204669002590 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 204669002591 putative ligand binding site [chemical binding]; other site 204669002592 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 204669002593 DNA binding site [nucleotide binding] 204669002594 domain linker motif; other site 204669002595 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 204669002596 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 204669002597 ligand binding site [chemical binding]; other site 204669002598 Family description; Region: VCBS; pfam13517 204669002599 Family description; Region: VCBS; pfam13517 204669002600 Family description; Region: VCBS; pfam13517 204669002601 Family description; Region: VCBS; pfam13517 204669002602 Family description; Region: VCBS; pfam13517 204669002603 Family description; Region: VCBS; pfam13517 204669002604 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 204669002605 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669002606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002607 binding surface 204669002608 TPR motif; other site 204669002609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002610 binding surface 204669002611 TPR motif; other site 204669002612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002613 binding surface 204669002614 TPR motif; other site 204669002615 TPR repeat; Region: TPR_11; pfam13414 204669002616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002617 binding surface 204669002618 TPR motif; other site 204669002619 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669002620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002621 binding surface 204669002622 TPR motif; other site 204669002623 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669002624 TPR repeat; Region: TPR_11; pfam13414 204669002625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002626 binding surface 204669002627 TPR motif; other site 204669002628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002629 binding surface 204669002630 TPR repeat; Region: TPR_11; pfam13414 204669002631 TPR motif; other site 204669002632 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669002633 TPR repeat; Region: TPR_11; pfam13414 204669002634 TPR repeat; Region: TPR_11; pfam13414 204669002635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002636 binding surface 204669002637 TPR motif; other site 204669002638 TPR repeat; Region: TPR_11; pfam13414 204669002639 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669002640 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 204669002641 Mechanosensitive ion channel; Region: MS_channel; pfam00924 204669002642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002643 binding surface 204669002644 TPR motif; other site 204669002645 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 204669002646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002647 TPR motif; other site 204669002648 TPR repeat; Region: TPR_11; pfam13414 204669002649 binding surface 204669002650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002651 binding surface 204669002652 TPR motif; other site 204669002653 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 204669002654 active site 204669002655 TPR repeat; Region: TPR_11; pfam13414 204669002656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002657 binding surface 204669002658 TPR motif; other site 204669002659 TPR repeat; Region: TPR_11; pfam13414 204669002660 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002661 binding surface 204669002662 TPR motif; other site 204669002663 TPR repeat; Region: TPR_11; pfam13414 204669002664 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002665 TPR motif; other site 204669002666 binding surface 204669002667 TPR repeat; Region: TPR_11; pfam13414 204669002668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002669 binding surface 204669002670 TPR motif; other site 204669002671 TPR repeat; Region: TPR_11; pfam13414 204669002672 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669002673 binding surface 204669002674 TPR motif; other site 204669002675 TPR repeat; Region: TPR_11; pfam13414 204669002676 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669002677 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669002678 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669002679 Family description; Region: VCBS; pfam13517 204669002680 Family description; Region: VCBS; pfam13517 204669002681 Family description; Region: VCBS; pfam13517 204669002682 Family description; Region: VCBS; pfam13517 204669002683 Family description; Region: VCBS; pfam13517 204669002684 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 204669002685 Family description; Region: VCBS; pfam13517 204669002686 Family description; Region: VCBS; pfam13517 204669002687 Family description; Region: VCBS; pfam13517 204669002688 Family description; Region: VCBS; pfam13517 204669002689 Family description; Region: VCBS; pfam13517 204669002690 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 204669002691 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 204669002692 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 204669002693 Ca binding site [ion binding]; other site 204669002694 active site 204669002695 catalytic site [active] 204669002696 Trehalase; Region: Trehalase; cl17346 204669002697 High-affinity nickel-transport protein; Region: NicO; cl00964 204669002698 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 204669002699 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 204669002700 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 204669002701 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 204669002702 Acylphosphatase; Region: Acylphosphatase; pfam00708 204669002703 HypF finger; Region: zf-HYPF; pfam07503 204669002704 HypF finger; Region: zf-HYPF; pfam07503 204669002705 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 204669002706 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 204669002707 Protein of unknown function (DUF1175); Region: DUF1175; pfam06672 204669002708 MG2 domain; Region: A2M_N; pfam01835 204669002709 MG2 domain; Region: A2M_N; pfam01835 204669002710 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 204669002711 Alpha-2-macroglobulin family; Region: A2M; pfam00207 204669002712 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 204669002713 surface patch; other site 204669002714 thioester region; other site 204669002715 specificity defining residues; other site 204669002716 Stage II sporulation protein; Region: SpoIID; pfam08486 204669002717 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 204669002718 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 204669002719 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 204669002720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 204669002721 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669002722 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669002723 tyrosine decarboxylase; Region: PLN02880 204669002724 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 204669002725 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 204669002726 catalytic residue [active] 204669002727 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 204669002728 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669002729 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 204669002730 putative active site [active] 204669002731 heme pocket [chemical binding]; other site 204669002732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669002733 dimer interface [polypeptide binding]; other site 204669002734 phosphorylation site [posttranslational modification] 204669002735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669002736 ATP binding site [chemical binding]; other site 204669002737 Mg2+ binding site [ion binding]; other site 204669002738 G-X-G motif; other site 204669002739 Response regulator receiver domain; Region: Response_reg; pfam00072 204669002740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669002741 active site 204669002742 phosphorylation site [posttranslational modification] 204669002743 intermolecular recognition site; other site 204669002744 dimerization interface [polypeptide binding]; other site 204669002745 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 204669002746 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 204669002747 N-terminal plug; other site 204669002748 ligand-binding site [chemical binding]; other site 204669002749 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 204669002750 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669002751 HAMP domain; Region: HAMP; pfam00672 204669002752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669002753 dimer interface [polypeptide binding]; other site 204669002754 phosphorylation site [posttranslational modification] 204669002755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669002756 ATP binding site [chemical binding]; other site 204669002757 Mg2+ binding site [ion binding]; other site 204669002758 G-X-G motif; other site 204669002759 Response regulator receiver domain; Region: Response_reg; pfam00072 204669002760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669002761 active site 204669002762 phosphorylation site [posttranslational modification] 204669002763 intermolecular recognition site; other site 204669002764 glutamate dehydrogenase; Provisional; Region: PRK09414 204669002765 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 204669002766 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 204669002767 NAD(P) binding site [chemical binding]; other site 204669002768 Melibiase; Region: Melibiase; pfam02065 204669002769 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 204669002770 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 204669002771 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 204669002772 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 204669002773 AlkA N-terminal domain; Region: AlkA_N; pfam06029 204669002774 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 204669002775 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 204669002776 minor groove reading motif; other site 204669002777 helix-hairpin-helix signature motif; other site 204669002778 substrate binding pocket [chemical binding]; other site 204669002779 active site 204669002780 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 204669002781 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 204669002782 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 204669002783 4Fe-4S binding domain; Region: Fer4; cl02805 204669002784 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 204669002785 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 204669002786 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 204669002787 dimer interface [polypeptide binding]; other site 204669002788 PYR/PP interface [polypeptide binding]; other site 204669002789 TPP binding site [chemical binding]; other site 204669002790 substrate binding site [chemical binding]; other site 204669002791 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 204669002792 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 204669002793 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 204669002794 TPP-binding site [chemical binding]; other site 204669002795 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 204669002796 Predicted permease; Region: DUF318; cl17795 204669002797 Protein of unknown function, DUF488; Region: DUF488; pfam04343 204669002798 Protein of unknown function, DUF488; Region: DUF488; pfam04343 204669002799 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 204669002800 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 204669002801 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669002802 GAF domain; Region: GAF; pfam01590 204669002803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669002804 PAS domain; Region: PAS_9; pfam13426 204669002805 putative active site [active] 204669002806 heme pocket [chemical binding]; other site 204669002807 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 204669002808 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 204669002809 metal binding site [ion binding]; metal-binding site 204669002810 active site 204669002811 I-site; other site 204669002812 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 204669002813 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 204669002814 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 204669002815 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 204669002816 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 204669002817 putative metal binding site [ion binding]; other site 204669002818 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 204669002819 active site 204669002820 catalytic triad [active] 204669002821 oxyanion hole [active] 204669002822 Methyltransferase domain; Region: Methyltransf_11; pfam08241 204669002823 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 204669002824 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669002825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669002826 active site 204669002827 phosphorylation site [posttranslational modification] 204669002828 intermolecular recognition site; other site 204669002829 dimerization interface [polypeptide binding]; other site 204669002830 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 204669002831 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 204669002832 Walker A/P-loop; other site 204669002833 ATP binding site [chemical binding]; other site 204669002834 Q-loop/lid; other site 204669002835 ABC transporter signature motif; other site 204669002836 Walker B; other site 204669002837 D-loop; other site 204669002838 H-loop/switch region; other site 204669002839 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 204669002840 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669002841 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669002842 active site 204669002843 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669002844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669002845 active site 204669002846 phosphorylation site [posttranslational modification] 204669002847 intermolecular recognition site; other site 204669002848 dimerization interface [polypeptide binding]; other site 204669002849 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669002850 DNA binding residues [nucleotide binding] 204669002851 dimerization interface [polypeptide binding]; other site 204669002852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669002853 Histidine kinase; Region: HisKA_3; pfam07730 204669002854 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 204669002855 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 204669002856 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 204669002857 DNA binding residues [nucleotide binding] 204669002858 putative dimer interface [polypeptide binding]; other site 204669002859 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 204669002860 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 204669002861 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 204669002862 HSP70 interaction site [polypeptide binding]; other site 204669002863 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 204669002864 substrate binding site [polypeptide binding]; other site 204669002865 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 204669002866 Zn binding sites [ion binding]; other site 204669002867 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 204669002868 dimer interface [polypeptide binding]; other site 204669002869 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 204669002870 putative active site [active] 204669002871 Methyltransferase domain; Region: Methyltransf_23; pfam13489 204669002872 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 204669002873 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 204669002874 nucleotide binding site [chemical binding]; other site 204669002875 NEF interaction site [polypeptide binding]; other site 204669002876 SBD interface [polypeptide binding]; other site 204669002877 Peptidase family M48; Region: Peptidase_M48; cl12018 204669002878 PQQ-like domain; Region: PQQ_2; pfam13360 204669002879 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669002880 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669002881 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669002882 FtsX-like permease family; Region: FtsX; pfam02687 204669002883 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 204669002884 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 204669002885 putative DNA binding site [nucleotide binding]; other site 204669002886 catalytic residue [active] 204669002887 putative H2TH interface [polypeptide binding]; other site 204669002888 putative catalytic residues [active] 204669002889 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 204669002890 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 204669002891 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 204669002892 DNA binding residues [nucleotide binding] 204669002893 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 204669002894 dimer interface [polypeptide binding]; other site 204669002895 metal binding site [ion binding]; metal-binding site 204669002896 Amidohydrolase; Region: Amidohydro_2; pfam04909 204669002897 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 204669002898 putative active site [active] 204669002899 hypothetical protein; Provisional; Region: PRK07208 204669002900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 204669002901 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 204669002902 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 204669002903 FAD binding pocket [chemical binding]; other site 204669002904 conserved FAD binding motif [chemical binding]; other site 204669002905 phosphate binding motif [ion binding]; other site 204669002906 beta-alpha-beta structure motif; other site 204669002907 NAD binding pocket [chemical binding]; other site 204669002908 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 204669002909 putative active site [active] 204669002910 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 204669002911 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 204669002912 homodimer interface [polypeptide binding]; other site 204669002913 homotetramer interface [polypeptide binding]; other site 204669002914 active site pocket [active] 204669002915 cleavage site 204669002916 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 204669002917 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 204669002918 active site 204669002919 motif I; other site 204669002920 motif II; other site 204669002921 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 204669002922 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 204669002923 glutaminase active site [active] 204669002924 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 204669002925 dimer interface [polypeptide binding]; other site 204669002926 active site 204669002927 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 204669002928 dimer interface [polypeptide binding]; other site 204669002929 active site 204669002930 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 204669002931 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 204669002932 Beta-lactamase; Region: Beta-lactamase; pfam00144 204669002933 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 204669002934 active site 204669002935 metal binding site [ion binding]; metal-binding site 204669002936 homotetramer interface [polypeptide binding]; other site 204669002937 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 204669002938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669002939 active site 204669002940 phosphorylation site [posttranslational modification] 204669002941 intermolecular recognition site; other site 204669002942 dimerization interface [polypeptide binding]; other site 204669002943 LytTr DNA-binding domain; Region: LytTR; smart00850 204669002944 Helix-turn-helix domain; Region: HTH_37; pfam13744 204669002945 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 204669002946 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 204669002947 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 204669002948 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 204669002949 Zn binding site [ion binding]; other site 204669002950 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 204669002951 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 204669002952 TMAO/DMSO reductase; Reviewed; Region: PRK05363 204669002953 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 204669002954 Moco binding site; other site 204669002955 metal coordination site [ion binding]; other site 204669002956 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 204669002957 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 204669002958 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 204669002959 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 204669002960 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 204669002961 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669002962 FeS/SAM binding site; other site 204669002963 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 204669002964 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 204669002965 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 204669002966 amidase; Provisional; Region: PRK08137 204669002967 Amidase; Region: Amidase; cl11426 204669002968 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 204669002969 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 204669002970 ligand binding site; other site 204669002971 oligomer interface; other site 204669002972 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 204669002973 dimer interface [polypeptide binding]; other site 204669002974 N-terminal domain interface [polypeptide binding]; other site 204669002975 sulfate 1 binding site; other site 204669002976 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 204669002977 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 204669002978 active site 204669002979 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 204669002980 homodimer interface [polypeptide binding]; other site 204669002981 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 204669002982 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669002983 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669002984 DNA binding residues [nucleotide binding] 204669002985 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK08343 204669002986 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 204669002987 Zn2+ binding site [ion binding]; other site 204669002988 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 204669002989 exopolyphosphatase; Region: exo_poly_only; TIGR03706 204669002990 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 204669002991 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 204669002992 catalytic core [active] 204669002993 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 204669002994 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 204669002995 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 204669002996 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 204669002997 putative domain interface [polypeptide binding]; other site 204669002998 putative active site [active] 204669002999 catalytic site [active] 204669003000 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 204669003001 putative domain interface [polypeptide binding]; other site 204669003002 putative active site [active] 204669003003 catalytic site [active] 204669003004 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669003005 Uncharacterized conserved protein [Function unknown]; Region: COG3595 204669003006 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 204669003007 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 204669003008 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 204669003009 Ligand binding site; other site 204669003010 Putative Catalytic site; other site 204669003011 DXD motif; other site 204669003012 Ferredoxin [Energy production and conversion]; Region: COG1146 204669003013 4Fe-4S binding domain; Region: Fer4; cl02805 204669003014 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 204669003015 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like_fungal; cd05652 204669003016 metal binding site [ion binding]; metal-binding site 204669003017 putative dimer interface [polypeptide binding]; other site 204669003018 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 204669003019 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 204669003020 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 204669003021 MOFRL family; Region: MOFRL; pfam05161 204669003022 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 204669003023 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 204669003024 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 204669003025 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 204669003026 RNA binding surface [nucleotide binding]; other site 204669003027 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 204669003028 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 204669003029 ATP-NAD kinase; Region: NAD_kinase; pfam01513 204669003030 BON domain; Region: BON; pfam04972 204669003031 BON domain; Region: BON; pfam04972 204669003032 urocanate hydratase; Provisional; Region: PRK05414 204669003033 imidazolonepropionase; Validated; Region: PRK09356 204669003034 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 204669003035 active site 204669003036 Peptidase family M1; Region: Peptidase_M1; pfam01433 204669003037 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 204669003038 Zn binding site [ion binding]; other site 204669003039 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 204669003040 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669003041 Catalytic domain of Protein Kinases; Region: PKc; cd00180 204669003042 active site 204669003043 ATP binding site [chemical binding]; other site 204669003044 substrate binding site [chemical binding]; other site 204669003045 activation loop (A-loop); other site 204669003046 Predicted integral membrane protein [Function unknown]; Region: COG5616 204669003047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669003048 TPR motif; other site 204669003049 binding surface 204669003050 TPR repeat; Region: TPR_11; pfam13414 204669003051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669003052 binding surface 204669003053 TPR motif; other site 204669003054 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669003055 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669003056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669003057 binding surface 204669003058 TPR motif; other site 204669003059 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 204669003060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669003061 putative substrate translocation pore; other site 204669003062 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 204669003063 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 204669003064 putative substrate binding site [chemical binding]; other site 204669003065 putative ATP binding site [chemical binding]; other site 204669003066 Smr domain; Region: Smr; pfam01713 204669003067 PilZ domain; Region: PilZ; pfam07238 204669003068 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 204669003069 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 204669003070 putative active site [active] 204669003071 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 204669003072 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 204669003073 active site 204669003074 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669003075 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 204669003076 DNA binding site [nucleotide binding] 204669003077 active site 204669003078 prolyl-tRNA synthetase; Provisional; Region: PRK09194 204669003079 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 204669003080 dimer interface [polypeptide binding]; other site 204669003081 motif 1; other site 204669003082 active site 204669003083 motif 2; other site 204669003084 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 204669003085 putative deacylase active site [active] 204669003086 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 204669003087 active site 204669003088 motif 3; other site 204669003089 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 204669003090 anticodon binding site; other site 204669003091 Transglycosylase; Region: Transgly; pfam00912 204669003092 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 204669003093 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 204669003094 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 204669003095 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 204669003096 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669003097 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 204669003098 Protein export membrane protein; Region: SecD_SecF; cl14618 204669003099 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 204669003100 enolase; Provisional; Region: eno; PRK00077 204669003101 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 204669003102 dimer interface [polypeptide binding]; other site 204669003103 metal binding site [ion binding]; metal-binding site 204669003104 substrate binding pocket [chemical binding]; other site 204669003105 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 204669003106 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 204669003107 phosphoglyceromutase; Provisional; Region: PRK05434 204669003108 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 204669003109 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 204669003110 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 204669003111 NAD binding site [chemical binding]; other site 204669003112 ligand binding site [chemical binding]; other site 204669003113 catalytic site [active] 204669003114 metal-dependent hydrolase; Provisional; Region: PRK13291 204669003115 DinB superfamily; Region: DinB_2; pfam12867 204669003116 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 204669003117 cofactor binding site; other site 204669003118 metal binding site [ion binding]; metal-binding site 204669003119 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 204669003120 HD domain; Region: HD_4; pfam13328 204669003121 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 204669003122 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 204669003123 active site 204669003124 Zn binding site [ion binding]; other site 204669003125 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 204669003126 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 204669003127 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 204669003128 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 204669003129 putative trimer interface [polypeptide binding]; other site 204669003130 putative active site [active] 204669003131 putative substrate binding site [chemical binding]; other site 204669003132 putative CoA binding site [chemical binding]; other site 204669003133 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 204669003134 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 204669003135 inhibitor-cofactor binding pocket; inhibition site 204669003136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669003137 catalytic residue [active] 204669003138 elongation factor P; Validated; Region: PRK00529 204669003139 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 204669003140 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 204669003141 RNA binding site [nucleotide binding]; other site 204669003142 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 204669003143 RNA binding site [nucleotide binding]; other site 204669003144 DinB family; Region: DinB; cl17821 204669003145 DinB superfamily; Region: DinB_2; pfam12867 204669003146 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669003147 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 204669003148 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669003149 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669003150 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669003151 FtsX-like permease family; Region: FtsX; pfam02687 204669003152 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 204669003153 B12 binding site [chemical binding]; other site 204669003154 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 204669003155 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669003156 FeS/SAM binding site; other site 204669003157 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 204669003158 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 204669003159 ParB-like nuclease domain; Region: ParBc; pfam02195 204669003160 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 204669003161 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 204669003162 ring oligomerisation interface [polypeptide binding]; other site 204669003163 ATP/Mg binding site [chemical binding]; other site 204669003164 stacking interactions; other site 204669003165 hinge regions; other site 204669003166 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 204669003167 oligomerisation interface [polypeptide binding]; other site 204669003168 mobile loop; other site 204669003169 roof hairpin; other site 204669003170 Peptidase family M48; Region: Peptidase_M48; pfam01435 204669003171 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 204669003172 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 204669003173 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 204669003174 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 204669003175 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 204669003176 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 204669003177 MOSC domain; Region: MOSC; pfam03473 204669003178 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 204669003179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669003180 S-adenosylmethionine binding site [chemical binding]; other site 204669003181 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 204669003182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669003183 NAD(P) binding site [chemical binding]; other site 204669003184 active site 204669003185 BON domain; Region: BON; pfam04972 204669003186 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 204669003187 Domain of unknown function (DUF955); Region: DUF955; pfam06114 204669003188 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 204669003189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669003190 non-specific DNA binding site [nucleotide binding]; other site 204669003191 salt bridge; other site 204669003192 sequence-specific DNA binding site [nucleotide binding]; other site 204669003193 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 204669003194 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 204669003195 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 204669003196 active site 204669003197 dimer interface [polypeptide binding]; other site 204669003198 effector binding site; other site 204669003199 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 204669003200 TSCPD domain; Region: TSCPD; pfam12637 204669003201 Predicted transcriptional regulator [Transcription]; Region: COG3905 204669003202 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 204669003203 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 204669003204 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 204669003205 cofactor binding site; other site 204669003206 DNA binding site [nucleotide binding] 204669003207 substrate interaction site [chemical binding]; other site 204669003208 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 204669003209 additional DNA contacts [nucleotide binding]; other site 204669003210 mismatch recognition site; other site 204669003211 active site 204669003212 zinc binding site [ion binding]; other site 204669003213 DNA intercalation site [nucleotide binding]; other site 204669003214 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 204669003215 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 204669003216 active site 204669003217 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669003218 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669003219 ligand binding site [chemical binding]; other site 204669003220 flexible hinge region; other site 204669003221 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 204669003222 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 204669003223 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 204669003224 FAD binding site [chemical binding]; other site 204669003225 homotetramer interface [polypeptide binding]; other site 204669003226 substrate binding pocket [chemical binding]; other site 204669003227 catalytic base [active] 204669003228 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 204669003229 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 204669003230 Int/Topo IB signature motif; other site 204669003231 AAA domain; Region: AAA_25; pfam13481 204669003232 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 204669003233 ATP binding site [chemical binding]; other site 204669003234 Walker A motif; other site 204669003235 Walker B motif; other site 204669003236 MarR family; Region: MarR_2; pfam12802 204669003237 Predicted membrane protein [Function unknown]; Region: COG2733 204669003238 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 204669003239 multiple promoter invertase; Provisional; Region: mpi; PRK13413 204669003240 catalytic residues [active] 204669003241 catalytic nucleophile [active] 204669003242 Presynaptic Site I dimer interface [polypeptide binding]; other site 204669003243 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 204669003244 Synaptic Flat tetramer interface [polypeptide binding]; other site 204669003245 Synaptic Site I dimer interface [polypeptide binding]; other site 204669003246 DNA binding site [nucleotide binding] 204669003247 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 204669003248 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 204669003249 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 204669003250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669003251 non-specific DNA binding site [nucleotide binding]; other site 204669003252 salt bridge; other site 204669003253 sequence-specific DNA binding site [nucleotide binding]; other site 204669003254 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 204669003255 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 204669003256 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 204669003257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669003258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 204669003259 Coenzyme A binding pocket [chemical binding]; other site 204669003260 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 204669003261 active site 204669003262 catalytic residues [active] 204669003263 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 204669003264 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 204669003265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669003266 putative substrate translocation pore; other site 204669003267 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 204669003268 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 204669003269 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669003270 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669003271 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 204669003272 Tetratricopeptide repeat; Region: TPR_6; pfam13174 204669003273 AMIN domain; Region: AMIN; pfam11741 204669003274 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 204669003275 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 204669003276 active site 204669003277 metal binding site [ion binding]; metal-binding site 204669003278 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 204669003279 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 204669003280 N-acetyl-D-glucosamine binding site [chemical binding]; other site 204669003281 catalytic residue [active] 204669003282 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 204669003283 active site 204669003284 ribulose/triose binding site [chemical binding]; other site 204669003285 phosphate binding site [ion binding]; other site 204669003286 substrate (anthranilate) binding pocket [chemical binding]; other site 204669003287 product (indole) binding pocket [chemical binding]; other site 204669003288 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 204669003289 active site 204669003290 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 204669003291 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 204669003292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669003293 catalytic residue [active] 204669003294 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 204669003295 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 204669003296 substrate binding site [chemical binding]; other site 204669003297 active site 204669003298 catalytic residues [active] 204669003299 heterodimer interface [polypeptide binding]; other site 204669003300 Chorismate mutase type II; Region: CM_2; cl00693 204669003301 prephenate dehydrogenase; Validated; Region: PRK08507 204669003302 Prephenate dehydrogenase; Region: PDH; pfam02153 204669003303 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 204669003304 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 204669003305 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 204669003306 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 204669003307 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 204669003308 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669003309 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 204669003310 dimer interface [polypeptide binding]; other site 204669003311 ligand binding site [chemical binding]; other site 204669003312 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669003313 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669003314 DNA binding site [nucleotide binding] 204669003315 Predicted integral membrane protein [Function unknown]; Region: COG5616 204669003316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669003317 TPR motif; other site 204669003318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 204669003319 TPR motif; other site 204669003320 binding surface 204669003321 Methyltransferase domain; Region: Methyltransf_31; pfam13847 204669003322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669003323 S-adenosylmethionine binding site [chemical binding]; other site 204669003324 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 204669003325 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669003326 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 204669003327 Isochorismatase family; Region: Isochorismatase; pfam00857 204669003328 catalytic triad [active] 204669003329 conserved cis-peptide bond; other site 204669003330 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 204669003331 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 204669003332 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 204669003333 active site 204669003334 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 204669003335 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669003336 dimerization interface [polypeptide binding]; other site 204669003337 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 204669003338 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669003339 Zn2+ binding site [ion binding]; other site 204669003340 Mg2+ binding site [ion binding]; other site 204669003341 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 204669003342 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 204669003343 Zn binding site [ion binding]; other site 204669003344 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 204669003345 putative amphipathic alpha helix; other site 204669003346 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 204669003347 Peptidase family M50; Region: Peptidase_M50; pfam02163 204669003348 active site 204669003349 putative substrate binding region [chemical binding]; other site 204669003350 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 204669003351 IHF - DNA interface [nucleotide binding]; other site 204669003352 IHF dimer interface [polypeptide binding]; other site 204669003353 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 204669003354 trimer interface [polypeptide binding]; other site 204669003355 active site 204669003356 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 204669003357 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669003358 Coenzyme A binding pocket [chemical binding]; other site 204669003359 Sm and related proteins; Region: Sm_like; cl00259 204669003360 heptamer interface [polypeptide binding]; other site 204669003361 Sm1 motif; other site 204669003362 hexamer interface [polypeptide binding]; other site 204669003363 RNA binding site [nucleotide binding]; other site 204669003364 Sm2 motif; other site 204669003365 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 204669003366 DNA polymerase III subunit delta'; Validated; Region: PRK08485 204669003367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669003368 S-adenosylmethionine binding site [chemical binding]; other site 204669003369 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 204669003370 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 204669003371 Recombination protein O N terminal; Region: RecO_N; pfam11967 204669003372 Recombination protein O C terminal; Region: RecO_C; pfam02565 204669003373 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 204669003374 motif 1; other site 204669003375 dimer interface [polypeptide binding]; other site 204669003376 active site 204669003377 motif 2; other site 204669003378 motif 3; other site 204669003379 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 204669003380 DALR anticodon binding domain; Region: DALR_1; pfam05746 204669003381 pyruvate phosphate dikinase; Provisional; Region: PRK09279 204669003382 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 204669003383 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 204669003384 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 204669003385 HipA-like N-terminal domain; Region: HipA_N; pfam07805 204669003386 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 204669003387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 204669003388 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 204669003389 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 204669003390 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 204669003391 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 204669003392 dimer interface [polypeptide binding]; other site 204669003393 anticodon binding site; other site 204669003394 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 204669003395 homodimer interface [polypeptide binding]; other site 204669003396 motif 1; other site 204669003397 active site 204669003398 motif 2; other site 204669003399 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 204669003400 active site 204669003401 motif 3; other site 204669003402 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 204669003403 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 204669003404 dimer interface [polypeptide binding]; other site 204669003405 motif 1; other site 204669003406 active site 204669003407 motif 2; other site 204669003408 motif 3; other site 204669003409 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 204669003410 anticodon binding site; other site 204669003411 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 204669003412 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 204669003413 trimer interface [polypeptide binding]; other site 204669003414 putative metal binding site [ion binding]; other site 204669003415 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 204669003416 Probable zinc-binding domain; Region: zf-trcl; pfam13451 204669003417 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 204669003418 Response regulator receiver domain; Region: Response_reg; pfam00072 204669003419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669003420 active site 204669003421 phosphorylation site [posttranslational modification] 204669003422 intermolecular recognition site; other site 204669003423 dimerization interface [polypeptide binding]; other site 204669003424 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 204669003425 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 204669003426 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669003427 FeS/SAM binding site; other site 204669003428 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 204669003429 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 204669003430 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 204669003431 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 204669003432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 204669003433 substrate binding site [chemical binding]; other site 204669003434 oxyanion hole (OAH) forming residues; other site 204669003435 trimer interface [polypeptide binding]; other site 204669003436 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 204669003437 homopentamer interface [polypeptide binding]; other site 204669003438 active site 204669003439 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 204669003440 putative RNA binding site [nucleotide binding]; other site 204669003441 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 204669003442 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669003443 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 204669003444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669003445 binding surface 204669003446 TPR repeat; Region: TPR_11; pfam13414 204669003447 TPR motif; other site 204669003448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669003449 binding surface 204669003450 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669003451 TPR motif; other site 204669003452 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 204669003453 S17 interaction site [polypeptide binding]; other site 204669003454 S8 interaction site; other site 204669003455 16S rRNA interaction site [nucleotide binding]; other site 204669003456 streptomycin interaction site [chemical binding]; other site 204669003457 23S rRNA interaction site [nucleotide binding]; other site 204669003458 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 204669003459 30S ribosomal protein S7; Validated; Region: PRK05302 204669003460 elongation factor G; Reviewed; Region: PRK00007 204669003461 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 204669003462 G1 box; other site 204669003463 putative GEF interaction site [polypeptide binding]; other site 204669003464 GTP/Mg2+ binding site [chemical binding]; other site 204669003465 Switch I region; other site 204669003466 G2 box; other site 204669003467 G3 box; other site 204669003468 Switch II region; other site 204669003469 G4 box; other site 204669003470 G5 box; other site 204669003471 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 204669003472 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 204669003473 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 204669003474 elongation factor Tu; Reviewed; Region: PRK00049 204669003475 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 204669003476 G1 box; other site 204669003477 GEF interaction site [polypeptide binding]; other site 204669003478 GTP/Mg2+ binding site [chemical binding]; other site 204669003479 Switch I region; other site 204669003480 G2 box; other site 204669003481 G3 box; other site 204669003482 Switch II region; other site 204669003483 G4 box; other site 204669003484 G5 box; other site 204669003485 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 204669003486 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 204669003487 Antibiotic Binding Site [chemical binding]; other site 204669003488 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 204669003489 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 204669003490 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 204669003491 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 204669003492 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 204669003493 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 204669003494 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 204669003495 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 204669003496 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 204669003497 putative translocon binding site; other site 204669003498 protein-rRNA interface [nucleotide binding]; other site 204669003499 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 204669003500 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 204669003501 G-X-X-G motif; other site 204669003502 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 204669003503 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 204669003504 23S rRNA interface [nucleotide binding]; other site 204669003505 5S rRNA interface [nucleotide binding]; other site 204669003506 putative antibiotic binding site [chemical binding]; other site 204669003507 L25 interface [polypeptide binding]; other site 204669003508 L27 interface [polypeptide binding]; other site 204669003509 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 204669003510 putative translocon interaction site; other site 204669003511 23S rRNA interface [nucleotide binding]; other site 204669003512 signal recognition particle (SRP54) interaction site; other site 204669003513 L23 interface [polypeptide binding]; other site 204669003514 trigger factor interaction site; other site 204669003515 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 204669003516 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 204669003517 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 204669003518 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 204669003519 RNA binding site [nucleotide binding]; other site 204669003520 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 204669003521 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 204669003522 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 204669003523 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 204669003524 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 204669003525 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 204669003526 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 204669003527 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 204669003528 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 204669003529 23S rRNA interface [nucleotide binding]; other site 204669003530 L21e interface [polypeptide binding]; other site 204669003531 5S rRNA interface [nucleotide binding]; other site 204669003532 L27 interface [polypeptide binding]; other site 204669003533 L5 interface [polypeptide binding]; other site 204669003534 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 204669003535 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 204669003536 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 204669003537 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 204669003538 23S rRNA binding site [nucleotide binding]; other site 204669003539 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 204669003540 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 204669003541 SecY translocase; Region: SecY; pfam00344 204669003542 adenylate kinase; Reviewed; Region: adk; PRK00279 204669003543 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 204669003544 AMP-binding site [chemical binding]; other site 204669003545 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 204669003546 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 204669003547 active site 204669003548 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 204669003549 rRNA binding site [nucleotide binding]; other site 204669003550 predicted 30S ribosome binding site; other site 204669003551 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 204669003552 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 204669003553 30S ribosomal protein S13; Region: bact_S13; TIGR03631 204669003554 30S ribosomal protein S11; Validated; Region: PRK05309 204669003555 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 204669003556 active site 204669003557 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669003558 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 204669003559 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 204669003560 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 204669003561 RNA binding surface [nucleotide binding]; other site 204669003562 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 204669003563 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 204669003564 alphaNTD homodimer interface [polypeptide binding]; other site 204669003565 alphaNTD - beta interaction site [polypeptide binding]; other site 204669003566 alphaNTD - beta' interaction site [polypeptide binding]; other site 204669003567 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 204669003568 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 204669003569 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 204669003570 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 204669003571 Predicted integral membrane protein [Function unknown]; Region: COG5652 204669003572 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 204669003573 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 204669003574 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 204669003575 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 204669003576 active site 204669003577 enoyl-CoA hydratase; Provisional; Region: PRK06688 204669003578 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 204669003579 substrate binding site [chemical binding]; other site 204669003580 oxyanion hole (OAH) forming residues; other site 204669003581 trimer interface [polypeptide binding]; other site 204669003582 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 204669003583 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 204669003584 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 204669003585 dimer interface [polypeptide binding]; other site 204669003586 active site 204669003587 glycine-pyridoxal phosphate binding site [chemical binding]; other site 204669003588 folate binding site [chemical binding]; other site 204669003589 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 204669003590 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 204669003591 gamma-glutamyl kinase; Provisional; Region: PRK05429 204669003592 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 204669003593 nucleotide binding site [chemical binding]; other site 204669003594 homotetrameric interface [polypeptide binding]; other site 204669003595 putative phosphate binding site [ion binding]; other site 204669003596 putative allosteric binding site; other site 204669003597 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 204669003598 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 204669003599 putative catalytic cysteine [active] 204669003600 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 204669003601 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 204669003602 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 204669003603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 204669003604 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 204669003605 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 204669003606 RNA 3'-phosphate cyclase; Region: RNA_3prim_cycl; TIGR03399 204669003607 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 204669003608 putative active site [active] 204669003609 adenylation catalytic residue [active] 204669003610 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 204669003611 hypothetical protein; Reviewed; Region: PRK09588 204669003612 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 204669003613 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 204669003614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669003615 Walker A motif; other site 204669003616 ATP binding site [chemical binding]; other site 204669003617 Walker B motif; other site 204669003618 arginine finger; other site 204669003619 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 204669003620 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 204669003621 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 204669003622 heme binding site [chemical binding]; other site 204669003623 ferroxidase pore; other site 204669003624 ferroxidase diiron center [ion binding]; other site 204669003625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669003626 binding surface 204669003627 TPR motif; other site 204669003628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669003629 binding surface 204669003630 TPR motif; other site 204669003631 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 204669003632 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 204669003633 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 204669003634 tyrosine decarboxylase; Region: PLN02880 204669003635 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 204669003636 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 204669003637 catalytic residue [active] 204669003638 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 204669003639 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 204669003640 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 204669003641 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 204669003642 DNA binding site [nucleotide binding] 204669003643 active site 204669003644 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669003645 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 204669003646 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669003647 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669003648 FtsX-like permease family; Region: FtsX; pfam02687 204669003649 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669003650 FtsX-like permease family; Region: FtsX; pfam02687 204669003651 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 204669003652 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 204669003653 dimer interface [polypeptide binding]; other site 204669003654 putative anticodon binding site; other site 204669003655 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 204669003656 motif 1; other site 204669003657 active site 204669003658 motif 2; other site 204669003659 motif 3; other site 204669003660 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 204669003661 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 204669003662 NADH dehydrogenase subunit D; Validated; Region: PRK06075 204669003663 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 204669003664 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 204669003665 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 204669003666 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 204669003667 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 204669003668 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 204669003669 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 204669003670 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 204669003671 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 204669003672 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 204669003673 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 204669003674 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 204669003675 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 204669003676 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 204669003677 ATP synthase I chain; Region: ATP_synt_I; cl09170 204669003678 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 204669003679 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 204669003680 ATP synthase subunit C; Region: ATP-synt_C; cl00466 204669003681 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 204669003682 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 204669003683 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 204669003684 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 204669003685 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 204669003686 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 204669003687 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 204669003688 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 204669003689 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 204669003690 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 204669003691 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499 204669003692 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 204669003693 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 204669003694 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 204669003695 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 204669003696 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 204669003697 catalytic loop [active] 204669003698 iron binding site [ion binding]; other site 204669003699 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 204669003700 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 204669003701 molybdopterin cofactor binding site; other site 204669003702 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 204669003703 SLBB domain; Region: SLBB; pfam10531 204669003704 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 204669003705 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 204669003706 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 204669003707 putative dimer interface [polypeptide binding]; other site 204669003708 [2Fe-2S] cluster binding site [ion binding]; other site 204669003709 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 204669003710 NADH dehydrogenase subunit D; Validated; Region: PRK06075 204669003711 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 204669003712 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 204669003713 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 204669003714 thiS-thiF/thiG interaction site; other site 204669003715 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 204669003716 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 204669003717 DNA binding residues [nucleotide binding] 204669003718 putative dimer interface [polypeptide binding]; other site 204669003719 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 204669003720 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 204669003721 Chromate transporter; Region: Chromate_transp; pfam02417 204669003722 Predicted membrane protein [Function unknown]; Region: COG2259 204669003723 Hemerythrin-like domain; Region: Hr-like; cd12108 204669003724 Fe binding site [ion binding]; other site 204669003725 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 204669003726 PspC domain; Region: PspC; pfam04024 204669003727 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669003728 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 204669003729 active site 204669003730 metal binding site [ion binding]; metal-binding site 204669003731 endonuclease IV; Provisional; Region: PRK01060 204669003732 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 204669003733 AP (apurinic/apyrimidinic) site pocket; other site 204669003734 DNA interaction; other site 204669003735 Metal-binding active site; metal-binding site 204669003736 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 204669003737 active site 204669003738 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 204669003739 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 204669003740 HIGH motif; other site 204669003741 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 204669003742 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 204669003743 active site 204669003744 KMSKS motif; other site 204669003745 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 204669003746 tRNA binding surface [nucleotide binding]; other site 204669003747 PQQ-like domain; Region: PQQ_2; pfam13360 204669003748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 204669003749 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 204669003750 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 204669003751 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 204669003752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669003753 dimerization interface [polypeptide binding]; other site 204669003754 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 204669003755 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 204669003756 Ubiquinol-cytochrome C reductase complex 14kD subunit; Region: UCR_14kD; pfam02271 204669003757 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 204669003758 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 204669003759 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 204669003760 Proline dehydrogenase; Region: Pro_dh; cl03282 204669003761 Uncharacterized conserved protein [Function unknown]; Region: COG2912 204669003762 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 204669003763 Cyclin-dependent kinase 5 activator protein; Region: CDK5_activator; pfam03261 204669003764 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 204669003765 Putative zinc-finger; Region: zf-HC2; pfam13490 204669003766 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 204669003767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669003768 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669003769 DNA binding residues [nucleotide binding] 204669003770 CHASE2 domain; Region: CHASE2; pfam05226 204669003771 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 204669003772 cyclase homology domain; Region: CHD; cd07302 204669003773 nucleotidyl binding site; other site 204669003774 metal binding site [ion binding]; metal-binding site 204669003775 dimer interface [polypeptide binding]; other site 204669003776 FecR protein; Region: FecR; pfam04773 204669003777 CARDB; Region: CARDB; pfam07705 204669003778 CARDB; Region: CARDB; pfam07705 204669003779 CARDB; Region: CARDB; pfam07705 204669003780 CARDB; Region: CARDB; pfam07705 204669003781 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 204669003782 AIR carboxylase; Region: AIRC; smart01001 204669003783 Protein of unknown function, DUF399; Region: DUF399; cl01139 204669003784 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 204669003785 Flavoprotein; Region: Flavoprotein; pfam02441 204669003786 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 204669003787 nudix motif; other site 204669003788 DinB superfamily; Region: DinB_2; pfam12867 204669003789 Transcriptional regulator [Transcription]; Region: LysR; COG0583 204669003790 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 204669003791 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 204669003792 dimerization interface [polypeptide binding]; other site 204669003793 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 204669003794 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 204669003795 dimer interface [polypeptide binding]; other site 204669003796 active site 204669003797 heme binding site [chemical binding]; other site 204669003798 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 204669003799 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 204669003800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669003801 Coenzyme A binding pocket [chemical binding]; other site 204669003802 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 204669003803 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 204669003804 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 204669003805 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 204669003806 PA/protease or protease-like domain interface [polypeptide binding]; other site 204669003807 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 204669003808 Peptidase family M28; Region: Peptidase_M28; pfam04389 204669003809 metal binding site [ion binding]; metal-binding site 204669003810 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 204669003811 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 204669003812 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 204669003813 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 204669003814 metal binding site [ion binding]; metal-binding site 204669003815 active site 204669003816 I-site; other site 204669003817 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669003818 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 204669003819 metal ion-dependent adhesion site (MIDAS); other site 204669003820 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 204669003821 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 204669003822 NAD(P) binding site [chemical binding]; other site 204669003823 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 204669003824 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 204669003825 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 204669003826 Tic20-like protein; Region: Tic20; pfam09685 204669003827 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 204669003828 putative active site [active] 204669003829 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 204669003830 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 204669003831 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 204669003832 AMP binding site [chemical binding]; other site 204669003833 active site 204669003834 acyl-activating enzyme (AAE) consensus motif; other site 204669003835 CoA binding site [chemical binding]; other site 204669003836 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 204669003837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669003838 NAD(P) binding site [chemical binding]; other site 204669003839 active site 204669003840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 204669003841 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 204669003842 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 204669003843 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 204669003844 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 204669003845 NAD(P) binding site [chemical binding]; other site 204669003846 catalytic residues [active] 204669003847 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 204669003848 L-aspartate oxidase; Provisional; Region: PRK06175 204669003849 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 204669003850 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 204669003851 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 204669003852 catalytic loop [active] 204669003853 iron binding site [ion binding]; other site 204669003854 Family description; Region: VCBS; pfam13517 204669003855 Family description; Region: VCBS; pfam13517 204669003856 Family description; Region: VCBS; pfam13517 204669003857 Family description; Region: VCBS; pfam13517 204669003858 Family description; Region: VCBS; pfam13517 204669003859 Family description; Region: VCBS; pfam13517 204669003860 Family description; Region: VCBS; pfam13517 204669003861 Family description; Region: VCBS; pfam13517 204669003862 Family description; Region: VCBS; pfam13517 204669003863 Family description; Region: VCBS; pfam13517 204669003864 Family description; Region: VCBS; pfam13517 204669003865 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669003866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669003867 active site 204669003868 phosphorylation site [posttranslational modification] 204669003869 intermolecular recognition site; other site 204669003870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669003871 Walker A motif; other site 204669003872 ATP binding site [chemical binding]; other site 204669003873 Walker B motif; other site 204669003874 arginine finger; other site 204669003875 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669003876 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 204669003877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669003878 putative active site [active] 204669003879 heme pocket [chemical binding]; other site 204669003880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669003881 dimer interface [polypeptide binding]; other site 204669003882 phosphorylation site [posttranslational modification] 204669003883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669003884 ATP binding site [chemical binding]; other site 204669003885 Mg2+ binding site [ion binding]; other site 204669003886 G-X-G motif; other site 204669003887 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 204669003888 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 204669003889 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 204669003890 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 204669003891 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 204669003892 Walker A motif; other site 204669003893 ATP binding site [chemical binding]; other site 204669003894 Walker B motif; other site 204669003895 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 204669003896 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 204669003897 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 204669003898 Walker A motif; other site 204669003899 ATP binding site [chemical binding]; other site 204669003900 Walker B motif; other site 204669003901 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669003902 dimerization interface [polypeptide binding]; other site 204669003903 PAS domain; Region: PAS; smart00091 204669003904 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 204669003905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669003906 dimer interface [polypeptide binding]; other site 204669003907 phosphorylation site [posttranslational modification] 204669003908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669003909 ATP binding site [chemical binding]; other site 204669003910 Mg2+ binding site [ion binding]; other site 204669003911 G-X-G motif; other site 204669003912 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669003913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669003914 active site 204669003915 phosphorylation site [posttranslational modification] 204669003916 intermolecular recognition site; other site 204669003917 dimerization interface [polypeptide binding]; other site 204669003918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669003919 Walker A motif; other site 204669003920 ATP binding site [chemical binding]; other site 204669003921 Walker B motif; other site 204669003922 arginine finger; other site 204669003923 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669003924 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 204669003925 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 204669003926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 204669003927 dimer interface [polypeptide binding]; other site 204669003928 conserved gate region; other site 204669003929 putative PBP binding loops; other site 204669003930 ABC-ATPase subunit interface; other site 204669003931 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 204669003932 oligomeric interface; other site 204669003933 putative active site [active] 204669003934 homodimer interface [polypeptide binding]; other site 204669003935 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 204669003936 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 204669003937 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669003938 non-specific DNA binding site [nucleotide binding]; other site 204669003939 salt bridge; other site 204669003940 sequence-specific DNA binding site [nucleotide binding]; other site 204669003941 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 204669003942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 204669003943 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 204669003944 phage shock protein A; Region: phageshock_pspA; TIGR02977 204669003945 RmuC family; Region: RmuC; pfam02646 204669003946 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 204669003947 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 204669003948 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 204669003949 active site 204669003950 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 204669003951 active sites [active] 204669003952 tetramer interface [polypeptide binding]; other site 204669003953 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 204669003954 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669003955 non-specific DNA binding site [nucleotide binding]; other site 204669003956 salt bridge; other site 204669003957 sequence-specific DNA binding site [nucleotide binding]; other site 204669003958 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669003959 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669003960 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 204669003961 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 204669003962 catalytic residue [active] 204669003963 putative FPP diphosphate binding site; other site 204669003964 putative FPP binding hydrophobic cleft; other site 204669003965 dimer interface [polypeptide binding]; other site 204669003966 putative IPP diphosphate binding site; other site 204669003967 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 204669003968 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 204669003969 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 204669003970 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 204669003971 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 204669003972 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 204669003973 RIP metalloprotease RseP; Region: TIGR00054 204669003974 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 204669003975 active site 204669003976 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 204669003977 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 204669003978 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 204669003979 putative substrate binding region [chemical binding]; other site 204669003980 Response regulator receiver domain; Region: Response_reg; pfam00072 204669003981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669003982 active site 204669003983 phosphorylation site [posttranslational modification] 204669003984 intermolecular recognition site; other site 204669003985 dimerization interface [polypeptide binding]; other site 204669003986 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669003987 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669003988 ligand binding site [chemical binding]; other site 204669003989 flexible hinge region; other site 204669003990 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 204669003991 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 204669003992 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 204669003993 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 204669003994 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 204669003995 putative dimer interface [polypeptide binding]; other site 204669003996 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669003997 Helix-turn-helix domain; Region: HTH_18; pfam12833 204669003998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 204669003999 enoyl-CoA hydratase; Provisional; Region: PRK05995 204669004000 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 204669004001 substrate binding site [chemical binding]; other site 204669004002 oxyanion hole (OAH) forming residues; other site 204669004003 trimer interface [polypeptide binding]; other site 204669004004 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 204669004005 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 204669004006 active site 204669004007 catalytic residues [active] 204669004008 metal binding site [ion binding]; metal-binding site 204669004009 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 204669004010 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 204669004011 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 204669004012 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 204669004013 HSP70 interaction site [polypeptide binding]; other site 204669004014 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 204669004015 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 204669004016 substrate binding site [chemical binding]; other site 204669004017 oxyanion hole (OAH) forming residues; other site 204669004018 trimer interface [polypeptide binding]; other site 204669004019 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 204669004020 B12 binding site [chemical binding]; other site 204669004021 cobalt ligand [ion binding]; other site 204669004022 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 204669004023 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 204669004024 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 204669004025 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 204669004026 protein binding site [polypeptide binding]; other site 204669004027 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 204669004028 EamA-like transporter family; Region: EamA; pfam00892 204669004029 EamA-like transporter family; Region: EamA; pfam00892 204669004030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 204669004031 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 204669004032 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 204669004033 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 204669004034 Walker A/P-loop; other site 204669004035 ATP binding site [chemical binding]; other site 204669004036 Q-loop/lid; other site 204669004037 ABC transporter signature motif; other site 204669004038 Walker B; other site 204669004039 D-loop; other site 204669004040 H-loop/switch region; other site 204669004041 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 204669004042 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669004043 non-specific DNA binding site [nucleotide binding]; other site 204669004044 salt bridge; other site 204669004045 sequence-specific DNA binding site [nucleotide binding]; other site 204669004046 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 204669004047 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 204669004048 active site 204669004049 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669004050 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 204669004051 putative metal binding site [ion binding]; other site 204669004052 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 204669004053 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 204669004054 NAD(P) binding site [chemical binding]; other site 204669004055 catalytic residues [active] 204669004056 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 204669004057 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 204669004058 dimerization interface 3.5A [polypeptide binding]; other site 204669004059 active site 204669004060 Outer membrane efflux protein; Region: OEP; pfam02321 204669004061 Outer membrane efflux protein; Region: OEP; pfam02321 204669004062 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 204669004063 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 204669004064 putative metal binding site; other site 204669004065 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 204669004066 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 204669004067 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 204669004068 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 204669004069 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 204669004070 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 204669004071 dimer interface [polypeptide binding]; other site 204669004072 MASE1; Region: MASE1; cl17823 204669004073 PAS domain S-box; Region: sensory_box; TIGR00229 204669004074 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669004075 putative active site [active] 204669004076 heme pocket [chemical binding]; other site 204669004077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 204669004078 Histidine kinase; Region: HisKA_3; pfam07730 204669004079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669004080 ATP binding site [chemical binding]; other site 204669004081 Mg2+ binding site [ion binding]; other site 204669004082 G-X-G motif; other site 204669004083 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 204669004084 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669004085 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669004086 active site 204669004087 ATP binding site [chemical binding]; other site 204669004088 substrate binding site [chemical binding]; other site 204669004089 activation loop (A-loop); other site 204669004090 Predicted integral membrane protein [Function unknown]; Region: COG5616 204669004091 TPR repeat; Region: TPR_11; pfam13414 204669004092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669004093 binding surface 204669004094 TPR motif; other site 204669004095 TPR repeat; Region: TPR_11; pfam13414 204669004096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669004097 binding surface 204669004098 TPR motif; other site 204669004099 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 204669004100 dimer interface [polypeptide binding]; other site 204669004101 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669004102 ligand binding site [chemical binding]; other site 204669004103 Cupin domain; Region: Cupin_2; cl17218 204669004104 aminotransferase AlaT; Validated; Region: PRK09265 204669004105 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 204669004106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669004107 homodimer interface [polypeptide binding]; other site 204669004108 catalytic residue [active] 204669004109 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 204669004110 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 204669004111 NAD binding site [chemical binding]; other site 204669004112 catalytic residues [active] 204669004113 rod shape-determining protein MreB; Provisional; Region: PRK13927 204669004114 MreB and similar proteins; Region: MreB_like; cd10225 204669004115 nucleotide binding site [chemical binding]; other site 204669004116 Mg binding site [ion binding]; other site 204669004117 putative protofilament interaction site [polypeptide binding]; other site 204669004118 RodZ interaction site [polypeptide binding]; other site 204669004119 rod shape-determining protein MreC; Provisional; Region: PRK13922 204669004120 rod shape-determining protein MreC; Region: MreC; pfam04085 204669004121 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 204669004122 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 204669004123 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 204669004124 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 204669004125 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 204669004126 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 204669004127 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 204669004128 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 204669004129 RNA binding site [nucleotide binding]; other site 204669004130 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 204669004131 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 204669004132 Helix-turn-helix domain; Region: HTH_17; pfam12728 204669004133 Cell division protein FtsA; Region: FtsA; cl17206 204669004134 Competence protein A; Region: Competence_A; pfam11104 204669004135 Cell division protein FtsA; Region: FtsA; pfam14450 204669004136 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 204669004137 Pilus assembly protein, PilO; Region: PilO; cl01234 204669004138 AMIN domain; Region: AMIN; pfam11741 204669004139 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 204669004140 Secretin and TonB N terminus short domain; Region: STN; smart00965 204669004141 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 204669004142 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 204669004143 amino acid transporter; Region: 2A0306; TIGR00909 204669004144 transaminase; Validated; Region: PRK07324 204669004145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 204669004146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669004147 homodimer interface [polypeptide binding]; other site 204669004148 catalytic residue [active] 204669004149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669004150 Major Facilitator Superfamily; Region: MFS_1; pfam07690 204669004151 putative substrate translocation pore; other site 204669004152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669004153 Transcriptional regulator [Transcription]; Region: LysR; COG0583 204669004154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 204669004155 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 204669004156 dimerization interface [polypeptide binding]; other site 204669004157 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 204669004158 pyrroline-5-carboxylate reductase; Region: PLN02688 204669004159 homoserine kinase; Provisional; Region: PRK01212 204669004160 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 204669004161 threonine synthase; Validated; Region: PRK06260 204669004162 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 204669004163 homodimer interface [polypeptide binding]; other site 204669004164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669004165 catalytic residue [active] 204669004166 homoserine dehydrogenase; Provisional; Region: PRK06349 204669004167 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 204669004168 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 204669004169 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 204669004170 aspartate kinase III; Validated; Region: PRK09084 204669004171 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 204669004172 putative catalytic residues [active] 204669004173 nucleotide binding site [chemical binding]; other site 204669004174 aspartate binding site [chemical binding]; other site 204669004175 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 204669004176 dimer interface [polypeptide binding]; other site 204669004177 allosteric regulatory binding pocket; other site 204669004178 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 204669004179 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 204669004180 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 204669004181 NAD binding site [chemical binding]; other site 204669004182 dimer interface [polypeptide binding]; other site 204669004183 substrate binding site [chemical binding]; other site 204669004184 tetramer (dimer of dimers) interface [polypeptide binding]; other site 204669004185 legume lectins; Region: lectin_L-type; cd01951 204669004186 homotetramer interaction site [polypeptide binding]; other site 204669004187 homodimer interaction site [polypeptide binding]; other site 204669004188 carbohydrate binding site [chemical binding]; other site 204669004189 metal binding site [ion binding]; metal-binding site 204669004190 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 204669004191 legume lectins; Region: lectin_L-type; cd01951 204669004192 homotetramer interaction site [polypeptide binding]; other site 204669004193 homodimer interaction site [polypeptide binding]; other site 204669004194 carbohydrate binding site [chemical binding]; other site 204669004195 metal binding site [ion binding]; metal-binding site 204669004196 trehalose synthase; Region: treS_nterm; TIGR02456 204669004197 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 204669004198 active site 204669004199 catalytic site [active] 204669004200 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 204669004201 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 204669004202 4-alpha-glucanotransferase; Provisional; Region: PRK14508 204669004203 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 204669004204 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 204669004205 metal binding triad; other site 204669004206 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 204669004207 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669004208 Zn2+ binding site [ion binding]; other site 204669004209 Mg2+ binding site [ion binding]; other site 204669004210 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 204669004211 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 204669004212 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 204669004213 Nitrogen regulatory protein P-II; Region: P-II; smart00938 204669004214 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 204669004215 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 204669004216 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 204669004217 active site 204669004218 Zn binding site [ion binding]; other site 204669004219 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 204669004220 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 204669004221 active site 204669004222 catalytic site [active] 204669004223 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 204669004224 Amidase; Region: Amidase; pfam01425 204669004225 GAF domain; Region: GAF; pfam01590 204669004226 GAF domain; Region: GAF_2; pfam13185 204669004227 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 204669004228 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669004229 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 204669004230 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 204669004231 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 204669004232 CARDB; Region: CARDB; pfam07705 204669004233 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669004234 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669004235 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669004236 ligand binding site [chemical binding]; other site 204669004237 flexible hinge region; other site 204669004238 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 204669004239 non-specific DNA interactions [nucleotide binding]; other site 204669004240 DNA binding site [nucleotide binding] 204669004241 sequence specific DNA binding site [nucleotide binding]; other site 204669004242 putative cAMP binding site [chemical binding]; other site 204669004243 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669004244 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669004245 ligand binding site [chemical binding]; other site 204669004246 flexible hinge region; other site 204669004247 Major Facilitator Superfamily; Region: MFS_1; pfam07690 204669004248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669004249 putative substrate translocation pore; other site 204669004250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669004251 putative substrate translocation pore; other site 204669004252 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669004253 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 204669004254 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 204669004255 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 204669004256 Ca binding site [ion binding]; other site 204669004257 active site 204669004258 homodimer interface [polypeptide binding]; other site 204669004259 catalytic site [active] 204669004260 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 204669004261 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 204669004262 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 204669004263 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 204669004264 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 204669004265 metal binding site [ion binding]; metal-binding site 204669004266 dimer interface [polypeptide binding]; other site 204669004267 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669004268 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 204669004269 FtsX-like permease family; Region: FtsX; pfam02687 204669004270 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669004271 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 204669004272 FtsX-like permease family; Region: FtsX; pfam02687 204669004273 hypothetical protein; Provisional; Region: PRK10621 204669004274 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 204669004275 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 204669004276 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 204669004277 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 204669004278 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 204669004279 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 204669004280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669004281 S-adenosylmethionine binding site [chemical binding]; other site 204669004282 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 204669004283 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 204669004284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669004285 Walker A/P-loop; other site 204669004286 ATP binding site [chemical binding]; other site 204669004287 Q-loop/lid; other site 204669004288 ABC transporter signature motif; other site 204669004289 Walker B; other site 204669004290 D-loop; other site 204669004291 H-loop/switch region; other site 204669004292 Predicted permeases [General function prediction only]; Region: COG0795 204669004293 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 204669004294 Predicted permeases [General function prediction only]; Region: COG0795 204669004295 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 204669004296 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 204669004297 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 204669004298 putative active site [active] 204669004299 catalytic site [active] 204669004300 Repair protein; Region: Repair_PSII; pfam04536 204669004301 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 204669004302 hypothetical protein; Provisional; Region: PRK08201 204669004303 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_1; cd05678 204669004304 putative metal binding site [ion binding]; other site 204669004305 putative dimer interface [polypeptide binding]; other site 204669004306 Phosphoesterase family; Region: Phosphoesterase; pfam04185 204669004307 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669004308 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 204669004309 active site 204669004310 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 204669004311 DNA-binding site [nucleotide binding]; DNA binding site 204669004312 RNA-binding motif; other site 204669004313 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 204669004314 putative binding surface; other site 204669004315 active site 204669004316 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 204669004317 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 204669004318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669004319 ATP binding site [chemical binding]; other site 204669004320 Mg2+ binding site [ion binding]; other site 204669004321 G-X-G motif; other site 204669004322 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 204669004323 CheW-like domain; Region: CheW; pfam01584 204669004324 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 204669004325 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 204669004326 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 204669004327 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 204669004328 dimer interface [polypeptide binding]; other site 204669004329 putative CheW interface [polypeptide binding]; other site 204669004330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669004331 Response regulator receiver domain; Region: Response_reg; pfam00072 204669004332 active site 204669004333 phosphorylation site [posttranslational modification] 204669004334 intermolecular recognition site; other site 204669004335 dimerization interface [polypeptide binding]; other site 204669004336 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 204669004337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669004338 active site 204669004339 phosphorylation site [posttranslational modification] 204669004340 intermolecular recognition site; other site 204669004341 dimerization interface [polypeptide binding]; other site 204669004342 CheB methylesterase; Region: CheB_methylest; pfam01339 204669004343 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 204669004344 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 204669004345 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 204669004346 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 204669004347 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 204669004348 NAD(P) binding site [chemical binding]; other site 204669004349 catalytic residues [active] 204669004350 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 204669004351 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 204669004352 inhibitor-cofactor binding pocket; inhibition site 204669004353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669004354 catalytic residue [active] 204669004355 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 204669004356 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 204669004357 tetrameric interface [polypeptide binding]; other site 204669004358 NAD binding site [chemical binding]; other site 204669004359 catalytic residues [active] 204669004360 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 204669004361 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 204669004362 inhibitor-cofactor binding pocket; inhibition site 204669004363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669004364 catalytic residue [active] 204669004365 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 204669004366 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 204669004367 tetramerization interface [polypeptide binding]; other site 204669004368 NAD(P) binding site [chemical binding]; other site 204669004369 catalytic residues [active] 204669004370 Amino acid permease; Region: AA_permease_2; pfam13520 204669004371 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 204669004372 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 204669004373 inhibitor-cofactor binding pocket; inhibition site 204669004374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669004375 catalytic residue [active] 204669004376 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669004377 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 204669004378 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 204669004379 DNA binding residues [nucleotide binding] 204669004380 dimer interface [polypeptide binding]; other site 204669004381 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 204669004382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669004383 non-specific DNA binding site [nucleotide binding]; other site 204669004384 salt bridge; other site 204669004385 sequence-specific DNA binding site [nucleotide binding]; other site 204669004386 Cupin domain; Region: Cupin_2; pfam07883 204669004387 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 204669004388 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 204669004389 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 204669004390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669004391 Walker A/P-loop; other site 204669004392 ATP binding site [chemical binding]; other site 204669004393 Q-loop/lid; other site 204669004394 ABC transporter signature motif; other site 204669004395 Walker B; other site 204669004396 D-loop; other site 204669004397 H-loop/switch region; other site 204669004398 TOBE domain; Region: TOBE_2; pfam08402 204669004399 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 204669004400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 204669004401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 204669004402 putative PBP binding loops; other site 204669004403 dimer interface [polypeptide binding]; other site 204669004404 ABC-ATPase subunit interface; other site 204669004405 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 204669004406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 204669004407 dimer interface [polypeptide binding]; other site 204669004408 conserved gate region; other site 204669004409 putative PBP binding loops; other site 204669004410 ABC-ATPase subunit interface; other site 204669004411 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 204669004412 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 204669004413 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669004414 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 204669004415 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669004416 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669004417 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 204669004418 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 204669004419 active site 204669004420 DNA polymerase IV; Validated; Region: PRK02406 204669004421 DNA binding site [nucleotide binding] 204669004422 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 204669004423 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 204669004424 DNA binding residues [nucleotide binding] 204669004425 molybdenum-pterin binding domain; Region: Mop; TIGR00638 204669004426 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669004427 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 204669004428 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 204669004429 ATP-grasp domain; Region: ATP-grasp_4; cl17255 204669004430 Transposase IS200 like; Region: Y1_Tnp; pfam01797 204669004431 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 204669004432 nickel binding site [ion binding]; other site 204669004433 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 204669004434 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 204669004435 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 204669004436 TPP-binding site [chemical binding]; other site 204669004437 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 204669004438 Found in ATP-dependent protease La (LON); Region: LON; smart00464 204669004439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669004440 Walker A motif; other site 204669004441 ATP binding site [chemical binding]; other site 204669004442 Walker B motif; other site 204669004443 arginine finger; other site 204669004444 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 204669004445 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 204669004446 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 204669004447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669004448 Walker A motif; other site 204669004449 ATP binding site [chemical binding]; other site 204669004450 Walker B motif; other site 204669004451 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 204669004452 Clp protease; Region: CLP_protease; pfam00574 204669004453 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 204669004454 oligomer interface [polypeptide binding]; other site 204669004455 active site residues [active] 204669004456 trigger factor; Region: tig; TIGR00115 204669004457 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 204669004458 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 204669004459 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 204669004460 active site 204669004461 catalytic residues [active] 204669004462 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 204669004463 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 204669004464 Fe-S cluster binding site [ion binding]; other site 204669004465 DNA binding site [nucleotide binding] 204669004466 active site 204669004467 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 204669004468 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 204669004469 NodB motif; other site 204669004470 putative active site [active] 204669004471 putative catalytic site [active] 204669004472 putative Zn binding site [ion binding]; other site 204669004473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 204669004474 TPR motif; other site 204669004475 binding surface 204669004476 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 204669004477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669004478 TPR motif; other site 204669004479 binding surface 204669004480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669004481 binding surface 204669004482 TPR motif; other site 204669004483 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 204669004484 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669004485 FeS/SAM binding site; other site 204669004486 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 204669004487 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 204669004488 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 204669004489 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 204669004490 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 204669004491 Walker A/P-loop; other site 204669004492 ATP binding site [chemical binding]; other site 204669004493 Q-loop/lid; other site 204669004494 ABC transporter signature motif; other site 204669004495 Walker B; other site 204669004496 D-loop; other site 204669004497 H-loop/switch region; other site 204669004498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 204669004499 TPR motif; other site 204669004500 binding surface 204669004501 TPR repeat; Region: TPR_11; pfam13414 204669004502 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 204669004503 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 204669004504 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 204669004505 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 204669004506 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 204669004507 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 204669004508 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 204669004509 Walker A motif; other site 204669004510 ATP binding site [chemical binding]; other site 204669004511 Walker B motif; other site 204669004512 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 204669004513 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 204669004514 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 204669004515 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 204669004516 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 204669004517 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 204669004518 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 204669004519 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 204669004520 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 204669004521 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 204669004522 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669004523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669004524 active site 204669004525 phosphorylation site [posttranslational modification] 204669004526 intermolecular recognition site; other site 204669004527 dimerization interface [polypeptide binding]; other site 204669004528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669004529 Walker A motif; other site 204669004530 ATP binding site [chemical binding]; other site 204669004531 Walker B motif; other site 204669004532 arginine finger; other site 204669004533 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669004534 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 204669004535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669004536 putative active site [active] 204669004537 heme pocket [chemical binding]; other site 204669004538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669004539 dimer interface [polypeptide binding]; other site 204669004540 phosphorylation site [posttranslational modification] 204669004541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669004542 ATP binding site [chemical binding]; other site 204669004543 G-X-G motif; other site 204669004544 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 204669004545 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 204669004546 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 204669004547 TPR repeat; Region: TPR_11; pfam13414 204669004548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669004549 TPR motif; other site 204669004550 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 204669004551 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 204669004552 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 204669004553 G1 box; other site 204669004554 GTP/Mg2+ binding site [chemical binding]; other site 204669004555 Switch I region; other site 204669004556 G2 box; other site 204669004557 G3 box; other site 204669004558 Switch II region; other site 204669004559 G4 box; other site 204669004560 G5 box; other site 204669004561 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 204669004562 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 204669004563 metal binding site [ion binding]; metal-binding site 204669004564 putative dimer interface [polypeptide binding]; other site 204669004565 Response regulator receiver domain; Region: Response_reg; pfam00072 204669004566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669004567 active site 204669004568 phosphorylation site [posttranslational modification] 204669004569 intermolecular recognition site; other site 204669004570 dimerization interface [polypeptide binding]; other site 204669004571 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669004572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669004573 active site 204669004574 phosphorylation site [posttranslational modification] 204669004575 intermolecular recognition site; other site 204669004576 dimerization interface [polypeptide binding]; other site 204669004577 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 204669004578 active site clefts [active] 204669004579 zinc binding site [ion binding]; other site 204669004580 dimer interface [polypeptide binding]; other site 204669004581 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 204669004582 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 204669004583 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 204669004584 Walker A/P-loop; other site 204669004585 ATP binding site [chemical binding]; other site 204669004586 Q-loop/lid; other site 204669004587 ABC transporter signature motif; other site 204669004588 Walker B; other site 204669004589 D-loop; other site 204669004590 H-loop/switch region; other site 204669004591 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 204669004592 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 204669004593 putative NAD(P) binding site [chemical binding]; other site 204669004594 putative active site [active] 204669004595 beta-lactamase TEM; Provisional; Region: PRK15442 204669004596 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 204669004597 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 204669004598 classical (c) SDRs; Region: SDR_c; cd05233 204669004599 NAD(P) binding site [chemical binding]; other site 204669004600 active site 204669004601 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858 204669004602 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 204669004603 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 204669004604 intersubunit interface [polypeptide binding]; other site 204669004605 active site 204669004606 zinc binding site [ion binding]; other site 204669004607 Na+ binding site [ion binding]; other site 204669004608 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 204669004609 ribonuclease PH; Reviewed; Region: rph; PRK00173 204669004610 Ribonuclease PH; Region: RNase_PH_bact; cd11362 204669004611 hexamer interface [polypeptide binding]; other site 204669004612 active site 204669004613 Phosphoesterase family; Region: Phosphoesterase; pfam04185 204669004614 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669004615 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 204669004616 FtsX-like permease family; Region: FtsX; pfam02687 204669004617 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669004618 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 204669004619 FtsX-like permease family; Region: FtsX; pfam02687 204669004620 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 204669004621 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 204669004622 Walker A/P-loop; other site 204669004623 ATP binding site [chemical binding]; other site 204669004624 Q-loop/lid; other site 204669004625 ABC transporter signature motif; other site 204669004626 Walker B; other site 204669004627 D-loop; other site 204669004628 H-loop/switch region; other site 204669004629 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 204669004630 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 204669004631 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669004632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669004633 S-adenosylmethionine binding site [chemical binding]; other site 204669004634 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 204669004635 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 204669004636 active site 204669004637 ADP/pyrophosphate binding site [chemical binding]; other site 204669004638 dimerization interface [polypeptide binding]; other site 204669004639 allosteric effector site; other site 204669004640 fructose-1,6-bisphosphate binding site; other site 204669004641 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 204669004642 Asp-box motif; other site 204669004643 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 204669004644 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 204669004645 tetramer interface [polypeptide binding]; other site 204669004646 active site 204669004647 Mg2+/Mn2+ binding site [ion binding]; other site 204669004648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669004649 metabolite-proton symporter; Region: 2A0106; TIGR00883 204669004650 putative substrate translocation pore; other site 204669004651 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 204669004652 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 204669004653 RNA binding surface [nucleotide binding]; other site 204669004654 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 204669004655 active site 204669004656 Transcriptional regulators [Transcription]; Region: PurR; COG1609 204669004657 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 204669004658 DNA binding site [nucleotide binding] 204669004659 domain linker motif; other site 204669004660 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 204669004661 dimerization interface [polypeptide binding]; other site 204669004662 ligand binding site [chemical binding]; other site 204669004663 Creatinine amidohydrolase; Region: Creatininase; pfam02633 204669004664 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 204669004665 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 204669004666 flagellar motor switch protein FliN; Region: fliN; TIGR02480 204669004667 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 204669004668 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 204669004669 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 204669004670 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669004671 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669004672 DNA binding residues [nucleotide binding] 204669004673 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 204669004674 FHIPEP family; Region: FHIPEP; pfam00771 204669004675 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 204669004676 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 204669004677 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 204669004678 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 204669004679 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 204669004680 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 204669004681 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 204669004682 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 204669004683 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 204669004684 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 204669004685 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 204669004686 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 204669004687 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 204669004688 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 204669004689 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 204669004690 Walker A motif; other site 204669004691 ATP binding site [chemical binding]; other site 204669004692 Walker B motif; other site 204669004693 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 204669004694 Flagellar assembly protein FliH; Region: FliH; pfam02108 204669004695 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 204669004696 FliG C-terminal domain; Region: FliG_C; pfam01706 204669004697 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 204669004698 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 204669004699 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 204669004700 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 204669004701 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 204669004702 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 204669004703 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 204669004704 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 204669004705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669004706 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 204669004707 Walker A motif; other site 204669004708 ATP binding site [chemical binding]; other site 204669004709 Walker B motif; other site 204669004710 arginine finger; other site 204669004711 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669004712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669004713 active site 204669004714 phosphorylation site [posttranslational modification] 204669004715 intermolecular recognition site; other site 204669004716 dimerization interface [polypeptide binding]; other site 204669004717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669004718 DNA binding site [nucleotide binding] 204669004719 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 204669004720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669004721 putative active site [active] 204669004722 heme pocket [chemical binding]; other site 204669004723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669004724 dimer interface [polypeptide binding]; other site 204669004725 phosphorylation site [posttranslational modification] 204669004726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669004727 ATP binding site [chemical binding]; other site 204669004728 Mg2+ binding site [ion binding]; other site 204669004729 G-X-G motif; other site 204669004730 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 204669004731 OstA-like protein; Region: OstA; cl00844 204669004732 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 204669004733 OstA-like protein; Region: OstA; cl00844 204669004734 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 204669004735 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 204669004736 Walker A/P-loop; other site 204669004737 ATP binding site [chemical binding]; other site 204669004738 Q-loop/lid; other site 204669004739 ABC transporter signature motif; other site 204669004740 Walker B; other site 204669004741 D-loop; other site 204669004742 H-loop/switch region; other site 204669004743 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 204669004744 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 204669004745 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 204669004746 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 204669004747 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 204669004748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 204669004749 Lipase maturation factor; Region: LMF1; pfam06762 204669004750 Divergent AAA domain; Region: AAA_4; pfam04326 204669004751 Beta-2-glycoprotein-1 fifth domain; Region: Sushi_2; pfam09014 204669004752 Right handed beta helix region; Region: Beta_helix; pfam13229 204669004753 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 204669004754 dimer interface [polypeptide binding]; other site 204669004755 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 204669004756 30S subunit binding site; other site 204669004757 DinB superfamily; Region: DinB_2; pfam12867 204669004758 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 204669004759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669004760 dimerization interface [polypeptide binding]; other site 204669004761 PAS fold; Region: PAS_4; pfam08448 204669004762 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 204669004763 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 204669004764 dimer interface [polypeptide binding]; other site 204669004765 putative CheW interface [polypeptide binding]; other site 204669004766 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 204669004767 dimanganese center [ion binding]; other site 204669004768 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 204669004769 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 204669004770 Iodothyronine deiodinase; Region: T4_deiodinase; pfam00837 204669004771 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 204669004772 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 204669004773 alpha-galactosidase; Region: PLN02808; cl17638 204669004774 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669004775 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669004776 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 204669004777 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 204669004778 Uncharacterized conserved protein [Function unknown]; Region: COG2128 204669004779 TPR repeat; Region: TPR_11; pfam13414 204669004780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669004781 binding surface 204669004782 TPR motif; other site 204669004783 TPR repeat; Region: TPR_11; pfam13414 204669004784 TPR repeat; Region: TPR_11; pfam13414 204669004785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669004786 binding surface 204669004787 TPR motif; other site 204669004788 Family description; Region: VCBS; pfam13517 204669004789 Family description; Region: VCBS; pfam13517 204669004790 Family description; Region: VCBS; pfam13517 204669004791 Family description; Region: VCBS; pfam13517 204669004792 Family description; Region: VCBS; pfam13517 204669004793 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 204669004794 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 204669004795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669004796 TPR repeat; Region: TPR_11; pfam13414 204669004797 binding surface 204669004798 TPR motif; other site 204669004799 TPR repeat; Region: TPR_11; pfam13414 204669004800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669004801 binding surface 204669004802 TPR motif; other site 204669004803 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669004804 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669004805 Family description; Region: VCBS; pfam13517 204669004806 Family description; Region: VCBS; pfam13517 204669004807 Family description; Region: VCBS; pfam13517 204669004808 Family description; Region: VCBS; pfam13517 204669004809 Family description; Region: VCBS; pfam13517 204669004810 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 204669004811 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 204669004812 Amidase; Region: Amidase; pfam01425 204669004813 Transcriptional regulators [Transcription]; Region: PurR; COG1609 204669004814 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 204669004815 DNA binding site [nucleotide binding] 204669004816 domain linker motif; other site 204669004817 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 204669004818 ligand binding site [chemical binding]; other site 204669004819 dimerization interface [polypeptide binding]; other site 204669004820 Transcriptional regulators [Transcription]; Region: PurR; COG1609 204669004821 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 204669004822 DNA binding site [nucleotide binding] 204669004823 domain linker motif; other site 204669004824 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 204669004825 dimerization interface [polypeptide binding]; other site 204669004826 ligand binding site [chemical binding]; other site 204669004827 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 204669004828 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 204669004829 Protein of unknown function, DUF608; Region: DUF608; pfam04685 204669004830 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 204669004831 Family description; Region: VCBS; pfam13517 204669004832 Family description; Region: VCBS; pfam13517 204669004833 Family description; Region: VCBS; pfam13517 204669004834 Family description; Region: VCBS; pfam13517 204669004835 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 204669004836 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669004837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669004838 active site 204669004839 phosphorylation site [posttranslational modification] 204669004840 intermolecular recognition site; other site 204669004841 dimerization interface [polypeptide binding]; other site 204669004842 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669004843 DNA binding residues [nucleotide binding] 204669004844 dimerization interface [polypeptide binding]; other site 204669004845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669004846 Histidine kinase; Region: HisKA_3; pfam07730 204669004847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669004848 ATP binding site [chemical binding]; other site 204669004849 Mg2+ binding site [ion binding]; other site 204669004850 G-X-G motif; other site 204669004851 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669004852 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 204669004853 active site 204669004854 metal binding site [ion binding]; metal-binding site 204669004855 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669004856 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 204669004857 active site 204669004858 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 204669004859 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 204669004860 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 204669004861 Domain of unknown function (DUF303); Region: DUF303; pfam03629 204669004862 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 204669004863 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 204669004864 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 204669004865 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 204669004866 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669004867 galactokinase; Provisional; Region: PRK05101 204669004868 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 204669004869 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 204669004870 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 204669004871 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 204669004872 NAD binding site [chemical binding]; other site 204669004873 homodimer interface [polypeptide binding]; other site 204669004874 active site 204669004875 substrate binding site [chemical binding]; other site 204669004876 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 204669004877 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 204669004878 dimer interface [polypeptide binding]; other site 204669004879 active site 204669004880 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 204669004881 dimerization interface [polypeptide binding]; other site 204669004882 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 204669004883 ATP binding site [chemical binding]; other site 204669004884 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 204669004885 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 204669004886 HupF/HypC family; Region: HupF_HypC; pfam01455 204669004887 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 204669004888 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669004889 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669004890 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669004891 FtsX-like permease family; Region: FtsX; pfam02687 204669004892 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669004893 FtsX-like permease family; Region: FtsX; pfam02687 204669004894 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 204669004895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 204669004896 DNA binding site [nucleotide binding] 204669004897 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 204669004898 Beta-lactamase; Region: Beta-lactamase; pfam00144 204669004899 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 204669004900 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 204669004901 Substrate binding site; other site 204669004902 Mg++ binding site; other site 204669004903 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 204669004904 active site 204669004905 substrate binding site [chemical binding]; other site 204669004906 CoA binding site [chemical binding]; other site 204669004907 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 204669004908 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 204669004909 Methyltransferase domain; Region: Methyltransf_23; pfam13489 204669004910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 204669004911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 204669004912 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 204669004913 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669004914 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 204669004915 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 204669004916 Walker A/P-loop; other site 204669004917 ATP binding site [chemical binding]; other site 204669004918 Q-loop/lid; other site 204669004919 ABC transporter signature motif; other site 204669004920 Walker B; other site 204669004921 D-loop; other site 204669004922 H-loop/switch region; other site 204669004923 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 204669004924 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 204669004925 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 204669004926 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 204669004927 Outer membrane efflux protein; Region: OEP; pfam02321 204669004928 Outer membrane efflux protein; Region: OEP; pfam02321 204669004929 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 204669004930 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 204669004931 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 204669004932 ligand binding site [chemical binding]; other site 204669004933 Predicted membrane protein [Function unknown]; Region: COG3503 204669004934 L-lactate permease; Region: Lactate_perm; cl00701 204669004935 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 204669004936 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 204669004937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 204669004938 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 204669004939 SPFH domain / Band 7 family; Region: Band_7; pfam01145 204669004940 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 204669004941 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 204669004942 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 204669004943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669004944 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669004945 dimerization interface [polypeptide binding]; other site 204669004946 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 204669004947 dimer interface [polypeptide binding]; other site 204669004948 phosphorylation site [posttranslational modification] 204669004949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669004950 ATP binding site [chemical binding]; other site 204669004951 Mg2+ binding site [ion binding]; other site 204669004952 G-X-G motif; other site 204669004953 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669004954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669004955 active site 204669004956 phosphorylation site [posttranslational modification] 204669004957 intermolecular recognition site; other site 204669004958 dimerization interface [polypeptide binding]; other site 204669004959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669004960 Walker A motif; other site 204669004961 ATP binding site [chemical binding]; other site 204669004962 Walker B motif; other site 204669004963 arginine finger; other site 204669004964 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 204669004965 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 204669004966 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 204669004967 hydroxyglutarate oxidase; Provisional; Region: PRK11728 204669004968 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669004969 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669004970 active site 204669004971 ATP binding site [chemical binding]; other site 204669004972 substrate binding site [chemical binding]; other site 204669004973 activation loop (A-loop); other site 204669004974 Predicted integral membrane protein [Function unknown]; Region: COG5616 204669004975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669004976 TPR motif; other site 204669004977 binding surface 204669004978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669004979 TPR motif; other site 204669004980 binding surface 204669004981 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669004982 Phospholipase B; Region: Phospholip_B; pfam04916 204669004983 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 204669004984 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 204669004985 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 204669004986 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 204669004987 Active site cavity [active] 204669004988 catalytic acid [active] 204669004989 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 204669004990 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 204669004991 putative NADP binding site [chemical binding]; other site 204669004992 putative substrate binding site [chemical binding]; other site 204669004993 active site 204669004994 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 204669004995 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 204669004996 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 204669004997 putative NAD(P) binding site [chemical binding]; other site 204669004998 catalytic Zn binding site [ion binding]; other site 204669004999 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 204669005000 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 204669005001 NAD(P) binding site [chemical binding]; other site 204669005002 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 204669005003 active site lid residues [active] 204669005004 substrate binding pocket [chemical binding]; other site 204669005005 catalytic residues [active] 204669005006 substrate-Mg2+ binding site; other site 204669005007 aspartate-rich region 1; other site 204669005008 aspartate-rich region 2; other site 204669005009 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 204669005010 active site lid residues [active] 204669005011 substrate binding pocket [chemical binding]; other site 204669005012 catalytic residues [active] 204669005013 substrate-Mg2+ binding site; other site 204669005014 aspartate-rich region 1; other site 204669005015 aspartate-rich region 2; other site 204669005016 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 204669005017 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 204669005018 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669005019 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669005020 ligand binding site [chemical binding]; other site 204669005021 flexible hinge region; other site 204669005022 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 204669005023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 204669005024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669005025 S-adenosylmethionine binding site [chemical binding]; other site 204669005026 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 204669005027 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 204669005028 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 204669005029 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 204669005030 active site 204669005031 substrate binding site [chemical binding]; other site 204669005032 metal binding site [ion binding]; metal-binding site 204669005033 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 204669005034 Septum formation initiator; Region: DivIC; pfam04977 204669005035 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 204669005036 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 204669005037 ThiS interaction site; other site 204669005038 putative active site [active] 204669005039 tetramer interface [polypeptide binding]; other site 204669005040 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 204669005041 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 204669005042 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 204669005043 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 204669005044 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 204669005045 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 204669005046 Helix-hairpin-helix motif; Region: HHH; pfam00633 204669005047 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 204669005048 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669005049 Catalytic domain of Protein Kinases; Region: PKc; cd00180 204669005050 active site 204669005051 ATP binding site [chemical binding]; other site 204669005052 substrate binding site [chemical binding]; other site 204669005053 activation loop (A-loop); other site 204669005054 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 204669005055 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 204669005056 anti sigma factor interaction site; other site 204669005057 regulatory phosphorylation site [posttranslational modification]; other site 204669005058 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 204669005059 putative deacylase active site [active] 204669005060 Uncharacterized conserved protein [Function unknown]; Region: COG3391 204669005061 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 204669005062 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 204669005063 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 204669005064 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 204669005065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669005066 Response regulator receiver domain; Region: Response_reg; pfam00072 204669005067 active site 204669005068 phosphorylation site [posttranslational modification] 204669005069 intermolecular recognition site; other site 204669005070 dimerization interface [polypeptide binding]; other site 204669005071 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 204669005072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669005073 active site 204669005074 phosphorylation site [posttranslational modification] 204669005075 intermolecular recognition site; other site 204669005076 dimerization interface [polypeptide binding]; other site 204669005077 CheB methylesterase; Region: CheB_methylest; pfam01339 204669005078 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 204669005079 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 204669005080 putative binding surface; other site 204669005081 active site 204669005082 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 204669005083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669005084 ATP binding site [chemical binding]; other site 204669005085 Mg2+ binding site [ion binding]; other site 204669005086 G-X-G motif; other site 204669005087 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 204669005088 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 204669005089 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 204669005090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669005091 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 204669005092 putative CheA interaction surface; other site 204669005093 CHASE3 domain; Region: CHASE3; cl05000 204669005094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669005095 dimerization interface [polypeptide binding]; other site 204669005096 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 204669005097 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 204669005098 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 204669005099 dimer interface [polypeptide binding]; other site 204669005100 putative CheW interface [polypeptide binding]; other site 204669005101 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669005102 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669005103 GAF domain; Region: GAF_3; pfam13492 204669005104 GAF domain; Region: GAF_3; pfam13492 204669005105 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669005106 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 204669005107 PAS domain; Region: PAS; smart00091 204669005108 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 204669005109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669005110 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 204669005111 putative active site [active] 204669005112 heme pocket [chemical binding]; other site 204669005113 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 204669005114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669005115 putative active site [active] 204669005116 heme pocket [chemical binding]; other site 204669005117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669005118 dimer interface [polypeptide binding]; other site 204669005119 phosphorylation site [posttranslational modification] 204669005120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669005121 ATP binding site [chemical binding]; other site 204669005122 G-X-G motif; other site 204669005123 Response regulator receiver domain; Region: Response_reg; pfam00072 204669005124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669005125 active site 204669005126 phosphorylation site [posttranslational modification] 204669005127 intermolecular recognition site; other site 204669005128 dimerization interface [polypeptide binding]; other site 204669005129 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669005130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669005131 active site 204669005132 phosphorylation site [posttranslational modification] 204669005133 intermolecular recognition site; other site 204669005134 dimerization interface [polypeptide binding]; other site 204669005135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669005136 Walker A motif; other site 204669005137 ATP binding site [chemical binding]; other site 204669005138 Walker B motif; other site 204669005139 arginine finger; other site 204669005140 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669005141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669005142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669005143 dimer interface [polypeptide binding]; other site 204669005144 phosphorylation site [posttranslational modification] 204669005145 excinuclease ABC subunit B; Provisional; Region: PRK05298 204669005146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 204669005147 ATP binding site [chemical binding]; other site 204669005148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 204669005149 nucleotide binding region [chemical binding]; other site 204669005150 ATP-binding site [chemical binding]; other site 204669005151 Ultra-violet resistance protein B; Region: UvrB; pfam12344 204669005152 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 204669005153 phosphoglycolate phosphatase; Provisional; Region: PRK13222 204669005154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 204669005155 motif II; other site 204669005156 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 204669005157 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 204669005158 putative NAD(P) binding site [chemical binding]; other site 204669005159 active site 204669005160 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 204669005161 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 204669005162 TPP-binding site [chemical binding]; other site 204669005163 tetramer interface [polypeptide binding]; other site 204669005164 heterodimer interface [polypeptide binding]; other site 204669005165 phosphorylation loop region [posttranslational modification] 204669005166 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 204669005167 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 204669005168 alpha subunit interface [polypeptide binding]; other site 204669005169 TPP binding site [chemical binding]; other site 204669005170 heterodimer interface [polypeptide binding]; other site 204669005171 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 204669005172 RNA polymerase sigma factor; Provisional; Region: PRK11922 204669005173 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669005174 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 204669005175 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 204669005176 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 204669005177 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 204669005178 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 204669005179 DoxX; Region: DoxX; cl17842 204669005180 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 204669005181 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 204669005182 GMP synthase; Reviewed; Region: guaA; PRK00074 204669005183 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 204669005184 AMP/PPi binding site [chemical binding]; other site 204669005185 candidate oxyanion hole; other site 204669005186 catalytic triad [active] 204669005187 potential glutamine specificity residues [chemical binding]; other site 204669005188 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 204669005189 ATP Binding subdomain [chemical binding]; other site 204669005190 Ligand Binding sites [chemical binding]; other site 204669005191 Dimerization subdomain; other site 204669005192 TPR repeat; Region: TPR_11; pfam13414 204669005193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669005194 binding surface 204669005195 TPR motif; other site 204669005196 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 204669005197 RNA binding site [nucleotide binding]; other site 204669005198 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 204669005199 RNA binding site [nucleotide binding]; other site 204669005200 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 204669005201 RNA binding site [nucleotide binding]; other site 204669005202 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 204669005203 RNA binding site [nucleotide binding]; other site 204669005204 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 204669005205 RNA binding site [nucleotide binding]; other site 204669005206 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669005207 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 204669005208 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 204669005209 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669005210 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669005211 DNA binding residues [nucleotide binding] 204669005212 Low affinity iron permease; Region: Iron_permease; pfam04120 204669005213 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 204669005214 cyclase homology domain; Region: CHD; cd07302 204669005215 nucleotidyl binding site; other site 204669005216 metal binding site [ion binding]; metal-binding site 204669005217 dimer interface [polypeptide binding]; other site 204669005218 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 204669005219 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 204669005220 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 204669005221 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 204669005222 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 204669005223 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 204669005224 TPP-binding site [chemical binding]; other site 204669005225 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 204669005226 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 204669005227 dimer interface [polypeptide binding]; other site 204669005228 PYR/PP interface [polypeptide binding]; other site 204669005229 TPP binding site [chemical binding]; other site 204669005230 substrate binding site [chemical binding]; other site 204669005231 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 204669005232 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 204669005233 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 204669005234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669005235 Response regulator receiver domain; Region: Response_reg; pfam00072 204669005236 active site 204669005237 phosphorylation site [posttranslational modification] 204669005238 intermolecular recognition site; other site 204669005239 dimerization interface [polypeptide binding]; other site 204669005240 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 204669005241 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669005242 putative active site [active] 204669005243 heme pocket [chemical binding]; other site 204669005244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669005245 dimer interface [polypeptide binding]; other site 204669005246 phosphorylation site [posttranslational modification] 204669005247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669005248 ATP binding site [chemical binding]; other site 204669005249 Mg2+ binding site [ion binding]; other site 204669005250 G-X-G motif; other site 204669005251 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669005252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669005253 active site 204669005254 phosphorylation site [posttranslational modification] 204669005255 intermolecular recognition site; other site 204669005256 dimerization interface [polypeptide binding]; other site 204669005257 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669005258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669005259 active site 204669005260 phosphorylation site [posttranslational modification] 204669005261 intermolecular recognition site; other site 204669005262 dimerization interface [polypeptide binding]; other site 204669005263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669005264 dimer interface [polypeptide binding]; other site 204669005265 phosphorylation site [posttranslational modification] 204669005266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669005267 ATP binding site [chemical binding]; other site 204669005268 Mg2+ binding site [ion binding]; other site 204669005269 G-X-G motif; other site 204669005270 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 204669005271 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669005272 Phosphoesterase family; Region: Phosphoesterase; pfam04185 204669005273 Predicted GTPase [General function prediction only]; Region: COG2403 204669005274 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 204669005275 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 204669005276 ornithine carbamoyltransferase; Provisional; Region: PRK00779 204669005277 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 204669005278 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 204669005279 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 204669005280 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 204669005281 putative substrate binding site [chemical binding]; other site 204669005282 nucleotide binding site [chemical binding]; other site 204669005283 nucleotide binding site [chemical binding]; other site 204669005284 homodimer interface [polypeptide binding]; other site 204669005285 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 204669005286 aspartate carbamoyltransferase; Region: PLN02527 204669005287 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 204669005288 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 204669005289 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 204669005290 inhibitor-cofactor binding pocket; inhibition site 204669005291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669005292 catalytic residue [active] 204669005293 Domain of unknown function DUF302; Region: DUF302; cl01364 204669005294 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 204669005295 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669005296 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669005297 DNA binding residues [nucleotide binding] 204669005298 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 204669005299 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669005300 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 204669005301 active site 204669005302 Double zinc ribbon; Region: DZR; pfam12773 204669005303 Double zinc ribbon; Region: DZR; pfam12773 204669005304 Outer membrane efflux protein; Region: OEP; pfam02321 204669005305 Outer membrane efflux protein; Region: OEP; pfam02321 204669005306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669005307 TPR motif; other site 204669005308 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669005309 binding surface 204669005310 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 204669005311 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 204669005312 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669005313 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 204669005314 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 204669005315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669005316 putative substrate translocation pore; other site 204669005317 Major Facilitator Superfamily; Region: MFS_1; pfam07690 204669005318 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 204669005319 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 204669005320 DXD motif; other site 204669005321 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 204669005322 Uncharacterized conserved protein [Function unknown]; Region: COG2128 204669005323 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 204669005324 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 204669005325 Amidohydrolase; Region: Amidohydro_2; pfam04909 204669005326 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 204669005327 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 204669005328 catalytic residues [active] 204669005329 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 204669005330 4Fe-4S binding domain; Region: Fer4; pfam00037 204669005331 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 204669005332 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 204669005333 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 204669005334 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 204669005335 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 204669005336 substrate binding pocket [chemical binding]; other site 204669005337 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 204669005338 B12 binding site [chemical binding]; other site 204669005339 cobalt ligand [ion binding]; other site 204669005340 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 204669005341 hypothetical protein; Provisional; Region: PRK08201 204669005342 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 204669005343 metal binding site [ion binding]; metal-binding site 204669005344 putative dimer interface [polypeptide binding]; other site 204669005345 Pirin-related protein [General function prediction only]; Region: COG1741 204669005346 Pirin; Region: Pirin; pfam02678 204669005347 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 204669005348 CoenzymeA binding site [chemical binding]; other site 204669005349 subunit interaction site [polypeptide binding]; other site 204669005350 PHB binding site; other site 204669005351 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 204669005352 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 204669005353 active site 204669005354 multimer interface [polypeptide binding]; other site 204669005355 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 204669005356 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 204669005357 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 204669005358 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 204669005359 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 204669005360 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 204669005361 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 204669005362 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 204669005363 active site 204669005364 HIGH motif; other site 204669005365 nucleotide binding site [chemical binding]; other site 204669005366 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 204669005367 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 204669005368 active site 204669005369 KMSKS motif; other site 204669005370 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 204669005371 tRNA binding surface [nucleotide binding]; other site 204669005372 anticodon binding site; other site 204669005373 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 204669005374 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669005375 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 204669005376 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 204669005377 Cl- selectivity filter; other site 204669005378 Cl- binding residues [ion binding]; other site 204669005379 pore gating glutamate residue; other site 204669005380 dimer interface [polypeptide binding]; other site 204669005381 FOG: CBS domain [General function prediction only]; Region: COG0517 204669005382 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593 204669005383 TPR repeat; Region: TPR_11; pfam13414 204669005384 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669005385 binding surface 204669005386 TPR motif; other site 204669005387 TPR repeat; Region: TPR_11; pfam13414 204669005388 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669005389 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 204669005390 metal ion-dependent adhesion site (MIDAS); other site 204669005391 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 204669005392 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 204669005393 Walker A/P-loop; other site 204669005394 ATP binding site [chemical binding]; other site 204669005395 Q-loop/lid; other site 204669005396 ABC transporter signature motif; other site 204669005397 Walker B; other site 204669005398 D-loop; other site 204669005399 H-loop/switch region; other site 204669005400 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 204669005401 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 204669005402 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669005403 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 204669005404 FtsX-like permease family; Region: FtsX; pfam02687 204669005405 Iron permease FTR1 family; Region: FTR1; cl00475 204669005406 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 204669005407 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 204669005408 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 204669005409 predicted active site [active] 204669005410 catalytic triad [active] 204669005411 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 204669005412 catalytic residues [active] 204669005413 dimer interface [polypeptide binding]; other site 204669005414 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 204669005415 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 204669005416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669005417 FeS/SAM binding site; other site 204669005418 TRAM domain; Region: TRAM; cl01282 204669005419 Bifunctional nuclease; Region: DNase-RNase; pfam02577 204669005420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 204669005421 putative PBP binding loops; other site 204669005422 dimer interface [polypeptide binding]; other site 204669005423 ABC-ATPase subunit interface; other site 204669005424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669005425 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 204669005426 Walker A/P-loop; other site 204669005427 ATP binding site [chemical binding]; other site 204669005428 Q-loop/lid; other site 204669005429 ABC transporter signature motif; other site 204669005430 Walker B; other site 204669005431 D-loop; other site 204669005432 H-loop/switch region; other site 204669005433 TOBE domain; Region: TOBE; pfam03459 204669005434 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 204669005435 FAD binding domain; Region: FAD_binding_4; pfam01565 204669005436 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 204669005437 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 204669005438 Rhomboid family; Region: Rhomboid; pfam01694 204669005439 TPR repeat; Region: TPR_11; pfam13414 204669005440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669005441 binding surface 204669005442 TPR motif; other site 204669005443 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 204669005444 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 204669005445 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 204669005446 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 204669005447 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 204669005448 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 204669005449 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 204669005450 Predicted membrane protein [Function unknown]; Region: COG4818 204669005451 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 204669005452 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 204669005453 Interferon-induced transmembrane protein; Region: CD225; pfam04505 204669005454 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 204669005455 Interferon-induced transmembrane protein; Region: CD225; pfam04505 204669005456 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 204669005457 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669005458 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669005459 FtsX-like permease family; Region: FtsX; pfam02687 204669005460 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669005461 FtsX-like permease family; Region: FtsX; pfam02687 204669005462 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 204669005463 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669005464 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 204669005465 DNA-binding site [nucleotide binding]; DNA binding site 204669005466 RNA-binding motif; other site 204669005467 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 204669005468 TIGR03118 family protein; Region: PEPCTERM_chp_1 204669005469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 204669005470 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 204669005471 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 204669005472 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 204669005473 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669005474 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 204669005475 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 204669005476 Preprotein translocase SecG subunit; Region: SecG; pfam03840 204669005477 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 204669005478 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 204669005479 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 204669005480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669005481 active site 204669005482 phosphorylation site [posttranslational modification] 204669005483 intermolecular recognition site; other site 204669005484 dimerization interface [polypeptide binding]; other site 204669005485 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669005486 Zn2+ binding site [ion binding]; other site 204669005487 Mg2+ binding site [ion binding]; other site 204669005488 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 204669005489 active site 204669005490 catalytic triad [active] 204669005491 oxyanion hole [active] 204669005492 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 204669005493 active site clefts [active] 204669005494 zinc binding site [ion binding]; other site 204669005495 dimer interface [polypeptide binding]; other site 204669005496 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 204669005497 cystathionine gamma-synthase; Provisional; Region: PRK07811 204669005498 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 204669005499 homodimer interface [polypeptide binding]; other site 204669005500 substrate-cofactor binding pocket; other site 204669005501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669005502 catalytic residue [active] 204669005503 Mechanosensitive ion channel; Region: MS_channel; pfam00924 204669005504 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 204669005505 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 204669005506 KWG Leptospira; Region: KWG; pfam07656 204669005507 KWG Leptospira; Region: KWG; pfam07656 204669005508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 204669005509 Transposase; Region: DEDD_Tnp_IS110; pfam01548 204669005510 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 204669005511 DoxX; Region: DoxX; pfam07681 204669005512 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 204669005513 putative deacylase active site [active] 204669005514 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 204669005515 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669005516 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 204669005517 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 204669005518 catalytic loop [active] 204669005519 iron binding site [ion binding]; other site 204669005520 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 204669005521 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 204669005522 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 204669005523 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 204669005524 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 204669005525 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 204669005526 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 204669005527 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669005528 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669005529 FtsX-like permease family; Region: FtsX; pfam02687 204669005530 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669005531 FtsX-like permease family; Region: FtsX; pfam02687 204669005532 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669005533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669005534 active site 204669005535 phosphorylation site [posttranslational modification] 204669005536 intermolecular recognition site; other site 204669005537 dimerization interface [polypeptide binding]; other site 204669005538 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 204669005539 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 204669005540 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 204669005541 trimer interface [polypeptide binding]; other site 204669005542 active site 204669005543 UDP-GlcNAc binding site [chemical binding]; other site 204669005544 lipid binding site [chemical binding]; lipid-binding site 204669005545 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 204669005546 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 204669005547 active site 204669005548 NTP binding site [chemical binding]; other site 204669005549 metal binding triad [ion binding]; metal-binding site 204669005550 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 204669005551 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 204669005552 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 204669005553 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 204669005554 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 204669005555 putative active site; other site 204669005556 catalytic triad [active] 204669005557 putative dimer interface [polypeptide binding]; other site 204669005558 deoxyhypusine synthase; Region: dhys; TIGR00321 204669005559 Deoxyhypusine synthase; Region: DS; cl00826 204669005560 CAAX protease self-immunity; Region: Abi; pfam02517 204669005561 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 204669005562 Transcriptional regulator [Transcription]; Region: LysR; COG0583 204669005563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 204669005564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 204669005565 dimerization interface [polypeptide binding]; other site 204669005566 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 204669005567 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 204669005568 putative NAD(P) binding site [chemical binding]; other site 204669005569 putative substrate binding site [chemical binding]; other site 204669005570 catalytic Zn binding site [ion binding]; other site 204669005571 structural Zn binding site [ion binding]; other site 204669005572 dimer interface [polypeptide binding]; other site 204669005573 OsmC-like protein; Region: OsmC; cl00767 204669005574 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 204669005575 dimerization interface [polypeptide binding]; other site 204669005576 putative DNA binding site [nucleotide binding]; other site 204669005577 putative Zn2+ binding site [ion binding]; other site 204669005578 isocitrate dehydrogenase; Validated; Region: PRK07362 204669005579 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 204669005580 malate dehydrogenase; Reviewed; Region: PRK06223 204669005581 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 204669005582 NAD(P) binding site [chemical binding]; other site 204669005583 dimer interface [polypeptide binding]; other site 204669005584 tetramer (dimer of dimers) interface [polypeptide binding]; other site 204669005585 substrate binding site [chemical binding]; other site 204669005586 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 204669005587 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 204669005588 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 204669005589 minor groove reading motif; other site 204669005590 helix-hairpin-helix signature motif; other site 204669005591 substrate binding pocket [chemical binding]; other site 204669005592 active site 204669005593 putative heme peroxidase; Provisional; Region: PRK12276 204669005594 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 204669005595 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 204669005596 putative active site [active] 204669005597 putative catalytic site [active] 204669005598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 204669005599 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 204669005600 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 204669005601 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 204669005602 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669005603 PAS domain; Region: PAS_9; pfam13426 204669005604 putative active site [active] 204669005605 heme pocket [chemical binding]; other site 204669005606 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 204669005607 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 204669005608 metal binding site [ion binding]; metal-binding site 204669005609 active site 204669005610 I-site; other site 204669005611 PilZ domain; Region: PilZ; pfam07238 204669005612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669005613 TPR motif; other site 204669005614 binding surface 204669005615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669005616 TPR motif; other site 204669005617 binding surface 204669005618 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 204669005619 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 204669005620 active site 204669005621 NTP binding site [chemical binding]; other site 204669005622 metal binding triad [ion binding]; metal-binding site 204669005623 antibiotic binding site [chemical binding]; other site 204669005624 Uncharacterized conserved protein [Function unknown]; Region: COG2361 204669005625 Response regulator receiver domain; Region: Response_reg; pfam00072 204669005626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669005627 active site 204669005628 phosphorylation site [posttranslational modification] 204669005629 intermolecular recognition site; other site 204669005630 dimerization interface [polypeptide binding]; other site 204669005631 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 204669005632 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 204669005633 active site 204669005634 catalytic tetrad [active] 204669005635 recombination protein RecR; Reviewed; Region: recR; PRK00076 204669005636 RecR protein; Region: RecR; pfam02132 204669005637 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 204669005638 putative active site [active] 204669005639 putative metal-binding site [ion binding]; other site 204669005640 tetramer interface [polypeptide binding]; other site 204669005641 hypothetical protein; Validated; Region: PRK00153 204669005642 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 204669005643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669005644 Walker A motif; other site 204669005645 ATP binding site [chemical binding]; other site 204669005646 Walker B motif; other site 204669005647 arginine finger; other site 204669005648 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 204669005649 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 204669005650 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 204669005651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669005652 S-adenosylmethionine binding site [chemical binding]; other site 204669005653 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 204669005654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669005655 AAA domain; Region: AAA_14; pfam13173 204669005656 Walker A/P-loop; other site 204669005657 ATP binding site [chemical binding]; other site 204669005658 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 204669005659 active site 204669005660 metal binding site [ion binding]; metal-binding site 204669005661 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 204669005662 anti sigma factor interaction site; other site 204669005663 regulatory phosphorylation site [posttranslational modification]; other site 204669005664 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 204669005665 trimer interface [polypeptide binding]; other site 204669005666 active site 204669005667 cystathionine beta-lyase; Provisional; Region: PRK07050 204669005668 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 204669005669 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 204669005670 catalytic residue [active] 204669005671 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 204669005672 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 204669005673 homodimer interface [polypeptide binding]; other site 204669005674 substrate-cofactor binding pocket; other site 204669005675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669005676 catalytic residue [active] 204669005677 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 204669005678 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 204669005679 homodimer interface [polypeptide binding]; other site 204669005680 substrate-cofactor binding pocket; other site 204669005681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669005682 catalytic residue [active] 204669005683 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 204669005684 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 204669005685 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 204669005686 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 204669005687 Domain of unknown function (DUF305); Region: DUF305; pfam03713 204669005688 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 204669005689 nucleoside/Zn binding site; other site 204669005690 dimer interface [polypeptide binding]; other site 204669005691 catalytic motif [active] 204669005692 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 204669005693 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 204669005694 putative active site [active] 204669005695 metal binding site [ion binding]; metal-binding site 204669005696 homodimer binding site [polypeptide binding]; other site 204669005697 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 204669005698 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 204669005699 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 204669005700 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 204669005701 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 204669005702 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669005703 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669005704 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 204669005705 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669005706 Uncharacterized conserved protein [Function unknown]; Region: COG3542 204669005707 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 204669005708 putative catalytic site [active] 204669005709 putative phosphate binding site [ion binding]; other site 204669005710 active site 204669005711 metal binding site A [ion binding]; metal-binding site 204669005712 DNA binding site [nucleotide binding] 204669005713 putative AP binding site [nucleotide binding]; other site 204669005714 putative metal binding site B [ion binding]; other site 204669005715 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 204669005716 16S/18S rRNA binding site [nucleotide binding]; other site 204669005717 S13e-L30e interaction site [polypeptide binding]; other site 204669005718 25S rRNA binding site [nucleotide binding]; other site 204669005719 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 204669005720 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 204669005721 RNase E interface [polypeptide binding]; other site 204669005722 trimer interface [polypeptide binding]; other site 204669005723 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 204669005724 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 204669005725 RNase E interface [polypeptide binding]; other site 204669005726 trimer interface [polypeptide binding]; other site 204669005727 active site 204669005728 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 204669005729 putative nucleic acid binding region [nucleotide binding]; other site 204669005730 G-X-X-G motif; other site 204669005731 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 204669005732 RNA binding site [nucleotide binding]; other site 204669005733 domain interface; other site 204669005734 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 204669005735 SmpB-tmRNA interface; other site 204669005736 Tetratricopeptide repeat; Region: TPR_2; pfam07719 204669005737 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 204669005738 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 204669005739 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 204669005740 dockerin binding interface; other site 204669005741 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 204669005742 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 204669005743 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 204669005744 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 204669005745 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 204669005746 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 204669005747 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 204669005748 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 204669005749 dimer interface [polypeptide binding]; other site 204669005750 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 204669005751 active site 204669005752 Fe binding site [ion binding]; other site 204669005753 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 204669005754 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 204669005755 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 204669005756 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 204669005757 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 204669005758 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 204669005759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669005760 Walker A/P-loop; other site 204669005761 ATP binding site [chemical binding]; other site 204669005762 Q-loop/lid; other site 204669005763 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 204669005764 ABC transporter signature motif; other site 204669005765 Walker B; other site 204669005766 ABC transporter; Region: ABC_tran_2; pfam12848 204669005767 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 204669005768 Immunoglobulin domain; Region: Ig; cl11960 204669005769 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 204669005770 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 204669005771 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 204669005772 dimer interface [polypeptide binding]; other site 204669005773 ADP-ribose binding site [chemical binding]; other site 204669005774 active site 204669005775 nudix motif; other site 204669005776 metal binding site [ion binding]; metal-binding site 204669005777 DinB superfamily; Region: DinB_2; pfam12867 204669005778 methionine sulfoxide reductase A; Provisional; Region: PRK14054 204669005779 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 204669005780 putative ligand binding site [chemical binding]; other site 204669005781 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 204669005782 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 204669005783 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 204669005784 dimer interface [polypeptide binding]; other site 204669005785 active site 204669005786 CoA binding pocket [chemical binding]; other site 204669005787 SprT-like family; Region: SprT-like; pfam10263 204669005788 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669005789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669005790 TPR motif; other site 204669005791 binding surface 204669005792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669005793 binding surface 204669005794 TPR motif; other site 204669005795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669005796 TPR motif; other site 204669005797 binding surface 204669005798 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 204669005799 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 204669005800 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 204669005801 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 204669005802 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 204669005803 Subunit I/III interface [polypeptide binding]; other site 204669005804 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 204669005805 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 204669005806 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669005807 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 204669005808 putative active site [active] 204669005809 putative metal binding residues [ion binding]; other site 204669005810 signature motif; other site 204669005811 putative triphosphate binding site [ion binding]; other site 204669005812 dimer interface [polypeptide binding]; other site 204669005813 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 204669005814 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 204669005815 substrate binding pocket [chemical binding]; other site 204669005816 chain length determination region; other site 204669005817 substrate-Mg2+ binding site; other site 204669005818 catalytic residues [active] 204669005819 aspartate-rich region 1; other site 204669005820 active site lid residues [active] 204669005821 aspartate-rich region 2; other site 204669005822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 204669005823 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 204669005824 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 204669005825 active site 204669005826 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 204669005827 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 204669005828 active site 204669005829 HIGH motif; other site 204669005830 KMSKS motif; other site 204669005831 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 204669005832 tRNA binding surface [nucleotide binding]; other site 204669005833 anticodon binding site; other site 204669005834 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 204669005835 dimer interface [polypeptide binding]; other site 204669005836 putative tRNA-binding site [nucleotide binding]; other site 204669005837 Protein of unknown function DUF111; Region: DUF111; pfam01969 204669005838 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 204669005839 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 204669005840 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 204669005841 active site 204669005842 HIGH motif; other site 204669005843 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 204669005844 tRNA binding surface [nucleotide binding]; other site 204669005845 anticodon binding site; other site 204669005846 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 204669005847 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 204669005848 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 204669005849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669005850 non-specific DNA binding site [nucleotide binding]; other site 204669005851 salt bridge; other site 204669005852 sequence-specific DNA binding site [nucleotide binding]; other site 204669005853 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 204669005854 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 204669005855 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 204669005856 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 204669005857 M28 Zn-Peptidases; Region: M28_like_4; cd08015 204669005858 Peptidase family M28; Region: Peptidase_M28; pfam04389 204669005859 metal binding site [ion binding]; metal-binding site 204669005860 CsbD-like; Region: CsbD; cl17424 204669005861 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 204669005862 Prephenate dehydratase; Region: PDT; pfam00800 204669005863 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 204669005864 putative L-Phe binding site [chemical binding]; other site 204669005865 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 204669005866 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 204669005867 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669005868 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669005869 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669005870 FtsX-like permease family; Region: FtsX; pfam02687 204669005871 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669005872 FtsX-like permease family; Region: FtsX; pfam02687 204669005873 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 204669005874 Found in ATP-dependent protease La (LON); Region: LON; smart00464 204669005875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669005876 Walker A motif; other site 204669005877 ATP binding site [chemical binding]; other site 204669005878 Walker B motif; other site 204669005879 Patatin phospholipase; Region: DUF3734; pfam12536 204669005880 arginine finger; other site 204669005881 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 204669005882 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 204669005883 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 204669005884 ligand binding site [chemical binding]; other site 204669005885 Site-specific recombinase; Region: SpecificRecomb; pfam10136 204669005886 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 204669005887 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 204669005888 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 204669005889 metal binding site [ion binding]; metal-binding site 204669005890 putative dimer interface [polypeptide binding]; other site 204669005891 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 204669005892 MoaE interaction surface [polypeptide binding]; other site 204669005893 MoeB interaction surface [polypeptide binding]; other site 204669005894 thiocarboxylated glycine; other site 204669005895 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 204669005896 MoaE homodimer interface [polypeptide binding]; other site 204669005897 MoaD interaction [polypeptide binding]; other site 204669005898 active site residues [active] 204669005899 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669005900 von Willebrand factor type A domain; Region: VWA_2; pfam13519 204669005901 metal ion-dependent adhesion site (MIDAS); other site 204669005902 Sm and related proteins; Region: Sm_like; cl00259 204669005903 heptamer interface [polypeptide binding]; other site 204669005904 Sm1 motif; other site 204669005905 hexamer interface [polypeptide binding]; other site 204669005906 RNA binding site [nucleotide binding]; other site 204669005907 Sm2 motif; other site 204669005908 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 204669005909 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 204669005910 active site 204669005911 dimerization interface [polypeptide binding]; other site 204669005912 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 204669005913 methionine aminopeptidase; Provisional; Region: PRK12318 204669005914 RloB-like protein; Region: RloB; pfam13707 204669005915 AAA domain; Region: AAA_23; pfam13476 204669005916 AAA domain; Region: AAA_21; pfam13304 204669005917 Helix-turn-helix domain; Region: HTH_36; pfam13730 204669005918 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 204669005919 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 204669005920 active site 204669005921 DNA binding site [nucleotide binding] 204669005922 Int/Topo IB signature motif; other site 204669005923 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 204669005924 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 204669005925 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 204669005926 N-terminal plug; other site 204669005927 ligand-binding site [chemical binding]; other site 204669005928 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 204669005929 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 204669005930 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 204669005931 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 204669005932 Uncharacterized conserved protein [Function unknown]; Region: COG0432 204669005933 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 204669005934 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 204669005935 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 204669005936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 204669005937 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 204669005938 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 204669005939 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 204669005940 acyl-activating enzyme (AAE) consensus motif; other site 204669005941 putative AMP binding site [chemical binding]; other site 204669005942 putative active site [active] 204669005943 putative CoA binding site [chemical binding]; other site 204669005944 Bacitracin resistance protein BacA; Region: BacA; pfam02673 204669005945 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 204669005946 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 204669005947 tetramer interface [polypeptide binding]; other site 204669005948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669005949 catalytic residue [active] 204669005950 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 204669005951 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 204669005952 putative ADP-binding pocket [chemical binding]; other site 204669005953 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 204669005954 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 204669005955 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 204669005956 trimer interface [polypeptide binding]; other site 204669005957 active site 204669005958 substrate binding site [chemical binding]; other site 204669005959 CoA binding site [chemical binding]; other site 204669005960 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 204669005961 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 204669005962 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 204669005963 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 204669005964 EcsC protein family; Region: EcsC; pfam12787 204669005965 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 204669005966 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 204669005967 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 204669005968 Bacterial PH domain; Region: DUF304; pfam03703 204669005969 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 204669005970 cysteine synthase; Region: PLN02565 204669005971 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 204669005972 dimer interface [polypeptide binding]; other site 204669005973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669005974 catalytic residue [active] 204669005975 serine O-acetyltransferase; Region: cysE; TIGR01172 204669005976 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 204669005977 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 204669005978 trimer interface [polypeptide binding]; other site 204669005979 active site 204669005980 substrate binding site [chemical binding]; other site 204669005981 CoA binding site [chemical binding]; other site 204669005982 metal-dependent hydrolase; Provisional; Region: PRK13291 204669005983 DinB superfamily; Region: DinB_2; pfam12867 204669005984 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 204669005985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669005986 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669005987 DNA binding residues [nucleotide binding] 204669005988 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669005989 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 204669005990 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 204669005991 multifunctional aminopeptidase A; Provisional; Region: PRK00913 204669005992 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 204669005993 interface (dimer of trimers) [polypeptide binding]; other site 204669005994 Substrate-binding/catalytic site; other site 204669005995 Zn-binding sites [ion binding]; other site 204669005996 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669005997 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669005998 ligand binding site [chemical binding]; other site 204669005999 flexible hinge region; other site 204669006000 PilZ domain; Region: PilZ; pfam07238 204669006001 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 204669006002 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 204669006003 hinge; other site 204669006004 active site 204669006005 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 204669006006 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 204669006007 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 204669006008 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 204669006009 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669006010 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 204669006011 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669006012 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 204669006013 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 204669006014 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 204669006015 putative active site [active] 204669006016 Mn binding site [ion binding]; other site 204669006017 Flagellin N-methylase; Region: FliB; cl00497 204669006018 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 204669006019 Uncharacterized conserved protein [Function unknown]; Region: COG2128 204669006020 H+ Antiporter protein; Region: 2A0121; TIGR00900 204669006021 hypothetical protein; Validated; Region: PRK00110 204669006022 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 204669006023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669006024 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 204669006025 Coenzyme A binding pocket [chemical binding]; other site 204669006026 Phosphoesterase family; Region: Phosphoesterase; pfam04185 204669006027 Phosphoesterase family; Region: Phosphoesterase; pfam04185 204669006028 Phosphoesterase family; Region: Phosphoesterase; pfam04185 204669006029 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 204669006030 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 204669006031 Multicopper oxidase; Region: Cu-oxidase; pfam00394 204669006032 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 204669006033 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 204669006034 Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643 204669006035 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 204669006036 Formiminotransferase domain; Region: FTCD; pfam02971 204669006037 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 204669006038 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 204669006039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669006040 FeS/SAM binding site; other site 204669006041 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 204669006042 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669006043 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669006044 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 204669006045 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 204669006046 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 204669006047 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 204669006048 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 204669006049 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 204669006050 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 204669006051 competence damage-inducible protein A; Provisional; Region: PRK00549 204669006052 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 204669006053 putative MPT binding site; other site 204669006054 Competence-damaged protein; Region: CinA; pfam02464 204669006055 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 204669006056 structural tetrad; other site 204669006057 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 204669006058 tetramer interfaces [polypeptide binding]; other site 204669006059 binuclear metal-binding site [ion binding]; other site 204669006060 Domain of unknown function (DUF329); Region: DUF329; pfam03884 204669006061 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 204669006062 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 204669006063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669006064 FeS/SAM binding site; other site 204669006065 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 204669006066 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 204669006067 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 204669006068 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 204669006069 Rossmann-like domain; Region: Rossmann-like; pfam10727 204669006070 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 204669006071 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 204669006072 dimerization interface [polypeptide binding]; other site 204669006073 active site 204669006074 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 204669006075 thiamine pyrophosphate protein; Provisional; Region: PRK08273 204669006076 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 204669006077 PYR/PP interface [polypeptide binding]; other site 204669006078 dimer interface [polypeptide binding]; other site 204669006079 tetramer interface [polypeptide binding]; other site 204669006080 TPP binding site [chemical binding]; other site 204669006081 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 204669006082 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 204669006083 TPP-binding site [chemical binding]; other site 204669006084 Hemerythrin; Region: Hemerythrin; cd12107 204669006085 Fe binding site [ion binding]; other site 204669006086 BON domain; Region: BON; pfam04972 204669006087 DinB superfamily; Region: DinB_2; pfam12867 204669006088 metal-dependent hydrolase; Provisional; Region: PRK13291 204669006089 ACT domain; Region: ACT_3; pfam10000 204669006090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 204669006091 Family description; Region: ACT_7; pfam13840 204669006092 Amino acid permease; Region: AA_permease_2; pfam13520 204669006093 tyrosine decarboxylase; Region: PLN02880 204669006094 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 204669006095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669006096 catalytic residue [active] 204669006097 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 204669006098 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 204669006099 metal-dependent hydrolase; Provisional; Region: PRK13291 204669006100 DinB superfamily; Region: DinB_2; pfam12867 204669006101 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 204669006102 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 204669006103 putative active site [active] 204669006104 putative metal binding site [ion binding]; other site 204669006105 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 204669006106 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 204669006107 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669006108 FeS/SAM binding site; other site 204669006109 Response regulator receiver domain; Region: Response_reg; pfam00072 204669006110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669006111 active site 204669006112 phosphorylation site [posttranslational modification] 204669006113 intermolecular recognition site; other site 204669006114 dimerization interface [polypeptide binding]; other site 204669006115 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 204669006116 Sodium Bile acid symporter family; Region: SBF; cl17470 204669006117 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 204669006118 Domain of unknown function DUF20; Region: UPF0118; pfam01594 204669006119 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 204669006120 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 204669006121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 204669006122 DNA-binding site [nucleotide binding]; DNA binding site 204669006123 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 204669006124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669006125 homodimer interface [polypeptide binding]; other site 204669006126 catalytic residue [active] 204669006127 NIPSNAP; Region: NIPSNAP; pfam07978 204669006128 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 204669006129 GYD domain; Region: GYD; pfam08734 204669006130 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669006131 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669006132 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669006133 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 204669006134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 204669006135 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 204669006136 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 204669006137 active site 204669006138 catalytic site [active] 204669006139 metal binding site [ion binding]; metal-binding site 204669006140 CAAX protease self-immunity; Region: Abi; pfam02517 204669006141 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 204669006142 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 204669006143 homodimer interface [polypeptide binding]; other site 204669006144 metal binding site [ion binding]; metal-binding site 204669006145 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 204669006146 homodimer interface [polypeptide binding]; other site 204669006147 active site 204669006148 putative chemical substrate binding site [chemical binding]; other site 204669006149 metal binding site [ion binding]; metal-binding site 204669006150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669006151 Coenzyme A binding pocket [chemical binding]; other site 204669006152 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 204669006153 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 204669006154 active site 204669006155 octamer interface [polypeptide binding]; other site 204669006156 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 204669006157 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 204669006158 phosphate binding site [ion binding]; other site 204669006159 putative substrate binding pocket [chemical binding]; other site 204669006160 dimer interface [polypeptide binding]; other site 204669006161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669006162 binding surface 204669006163 TPR motif; other site 204669006164 TPR repeat; Region: TPR_11; pfam13414 204669006165 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 204669006166 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 204669006167 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 204669006168 Catalytic site [active] 204669006169 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 204669006170 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 204669006171 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 204669006172 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 204669006173 catalytic site [active] 204669006174 subunit interface [polypeptide binding]; other site 204669006175 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 204669006176 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 204669006177 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 204669006178 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 204669006179 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 204669006180 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 204669006181 ATP-grasp domain; Region: ATP-grasp_4; cl17255 204669006182 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 204669006183 IMP binding site; other site 204669006184 dimer interface [polypeptide binding]; other site 204669006185 interdomain contacts; other site 204669006186 partial ornithine binding site; other site 204669006187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 204669006188 DNA-binding site [nucleotide binding]; DNA binding site 204669006189 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 204669006190 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 204669006191 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 204669006192 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 204669006193 RNA binding site [nucleotide binding]; other site 204669006194 active site 204669006195 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 204669006196 YCII-related domain; Region: YCII; cl00999 204669006197 short chain dehydrogenase; Provisional; Region: PRK07326 204669006198 classical (c) SDRs; Region: SDR_c; cd05233 204669006199 NAD(P) binding site [chemical binding]; other site 204669006200 active site 204669006201 GTP cyclohydrolase I; Provisional; Region: PLN03044 204669006202 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 204669006203 homodecamer interface [polypeptide binding]; other site 204669006204 active site 204669006205 putative catalytic site residues [active] 204669006206 zinc binding site [ion binding]; other site 204669006207 GTP-CH-I/GFRP interaction surface; other site 204669006208 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 204669006209 active site 204669006210 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 204669006211 active site 204669006212 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 204669006213 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 204669006214 active site 204669006215 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 204669006216 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 204669006217 catalytic residues [active] 204669006218 DoxX-like family; Region: DoxX_2; pfam13564 204669006219 YHS domain; Region: YHS; pfam04945 204669006220 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 204669006221 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 204669006222 Soluble P-type ATPase [General function prediction only]; Region: COG4087 204669006223 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 204669006224 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 204669006225 active site 204669006226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 204669006227 SnoaL-like domain; Region: SnoaL_2; pfam12680 204669006228 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 204669006229 UbiA prenyltransferase family; Region: UbiA; pfam01040 204669006230 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669006231 Catalytic domain of Protein Kinases; Region: PKc; cd00180 204669006232 active site 204669006233 ATP binding site [chemical binding]; other site 204669006234 substrate binding site [chemical binding]; other site 204669006235 activation loop (A-loop); other site 204669006236 translocation protein TolB; Provisional; Region: tolB; PRK04922 204669006237 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 204669006238 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 204669006239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669006240 Walker A/P-loop; other site 204669006241 ATP binding site [chemical binding]; other site 204669006242 Q-loop/lid; other site 204669006243 ABC transporter signature motif; other site 204669006244 Walker B; other site 204669006245 D-loop; other site 204669006246 H-loop/switch region; other site 204669006247 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 204669006248 ABC-2 type transporter; Region: ABC2_membrane; cl17235 204669006249 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 204669006250 Protein of unknown function (DUF420); Region: DUF420; pfam04238 204669006251 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 204669006252 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 204669006253 dimer interface [polypeptide binding]; other site 204669006254 ssDNA binding site [nucleotide binding]; other site 204669006255 tetramer (dimer of dimers) interface [polypeptide binding]; other site 204669006256 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 204669006257 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 204669006258 oligomer interface [polypeptide binding]; other site 204669006259 metal binding site [ion binding]; metal-binding site 204669006260 metal binding site [ion binding]; metal-binding site 204669006261 putative Cl binding site [ion binding]; other site 204669006262 aspartate ring; other site 204669006263 basic sphincter; other site 204669006264 hydrophobic gate; other site 204669006265 periplasmic entrance; other site 204669006266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669006267 TPR motif; other site 204669006268 binding surface 204669006269 SET domain; Region: SET; pfam00856 204669006270 Cysteine-rich motif following a subset of SET domains; Region: PostSET; smart00508 204669006271 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 204669006272 Zn binding site [ion binding]; other site 204669006273 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 204669006274 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 204669006275 catalytic residues [active] 204669006276 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 204669006277 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 204669006278 active site 204669006279 catalytic tetrad [active] 204669006280 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 204669006281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669006282 Response regulator receiver domain; Region: Response_reg; pfam00072 204669006283 active site 204669006284 phosphorylation site [posttranslational modification] 204669006285 intermolecular recognition site; other site 204669006286 dimerization interface [polypeptide binding]; other site 204669006287 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 204669006288 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 204669006289 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 204669006290 putative active site [active] 204669006291 catalytic triad [active] 204669006292 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 204669006293 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 204669006294 dimerization interface [polypeptide binding]; other site 204669006295 ligand binding site [chemical binding]; other site 204669006296 NADP binding site [chemical binding]; other site 204669006297 catalytic site [active] 204669006298 transketolase; Reviewed; Region: PRK05899 204669006299 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 204669006300 TPP-binding site [chemical binding]; other site 204669006301 dimer interface [polypeptide binding]; other site 204669006302 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 204669006303 PYR/PP interface [polypeptide binding]; other site 204669006304 dimer interface [polypeptide binding]; other site 204669006305 TPP binding site [chemical binding]; other site 204669006306 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 204669006307 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 204669006308 homotrimer interaction site [polypeptide binding]; other site 204669006309 putative active site [active] 204669006310 This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein; Region: BCS1_N; smart01024 204669006311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669006312 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 204669006313 Walker A motif; other site 204669006314 ATP binding site [chemical binding]; other site 204669006315 Walker B motif; other site 204669006316 arginine finger; other site 204669006317 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 204669006318 GH3 auxin-responsive promoter; Region: GH3; pfam03321 204669006319 aspartate aminotransferase; Provisional; Region: PRK05764 204669006320 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 204669006321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669006322 homodimer interface [polypeptide binding]; other site 204669006323 catalytic residue [active] 204669006324 OsmC-like protein; Region: OsmC; cl00767 204669006325 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 204669006326 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 204669006327 Cation efflux family; Region: Cation_efflux; cl00316 204669006328 Cation efflux family; Region: Cation_efflux; cl00316 204669006329 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 204669006330 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 204669006331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669006332 NAD(P) binding site [chemical binding]; other site 204669006333 active site 204669006334 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 204669006335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669006336 S-adenosylmethionine binding site [chemical binding]; other site 204669006337 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 204669006338 active site 204669006339 dimer interface [polypeptide binding]; other site 204669006340 metal binding site [ion binding]; metal-binding site 204669006341 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 204669006342 L-aspartate oxidase; Provisional; Region: PRK06175 204669006343 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 204669006344 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 204669006345 NADH dehydrogenase subunit B; Validated; Region: PRK06411 204669006346 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 204669006347 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 204669006348 active site 204669006349 catalytic tetrad [active] 204669006350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669006351 Coenzyme A binding pocket [chemical binding]; other site 204669006352 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 204669006353 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 204669006354 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 204669006355 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 204669006356 ATP binding site [chemical binding]; other site 204669006357 active site 204669006358 substrate binding site [chemical binding]; other site 204669006359 Colicin V production protein; Region: Colicin_V; pfam02674 204669006360 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669006361 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 204669006362 short chain dehydrogenase; Provisional; Region: PRK07326 204669006363 classical (c) SDRs; Region: SDR_c; cd05233 204669006364 NAD(P) binding site [chemical binding]; other site 204669006365 active site 204669006366 DinB superfamily; Region: DinB_2; pfam12867 204669006367 YtxH-like protein; Region: YtxH; pfam12732 204669006368 short chain dehydrogenase; Provisional; Region: PRK06500 204669006369 classical (c) SDRs; Region: SDR_c; cd05233 204669006370 NAD(P) binding site [chemical binding]; other site 204669006371 active site 204669006372 Cupin; Region: Cupin_6; pfam12852 204669006373 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 204669006374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 204669006375 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 204669006376 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 204669006377 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 204669006378 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669006379 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 204669006380 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 204669006381 Ligand Binding Site [chemical binding]; other site 204669006382 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 204669006383 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 204669006384 NAD binding site [chemical binding]; other site 204669006385 active site 204669006386 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 204669006387 Family description; Region: VCBS; pfam13517 204669006388 Family description; Region: VCBS; pfam13517 204669006389 Family description; Region: VCBS; pfam13517 204669006390 Family description; Region: VCBS; pfam13517 204669006391 Family description; Region: VCBS; pfam13517 204669006392 Family description; Region: VCBS; pfam13517 204669006393 Family description; Region: VCBS; pfam13517 204669006394 Family description; Region: VCBS; pfam13517 204669006395 Family description; Region: VCBS; pfam13517 204669006396 Family description; Region: VCBS; pfam13517 204669006397 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 204669006398 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 204669006399 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 204669006400 catalytic residue [active] 204669006401 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 204669006402 dimer interface [polypeptide binding]; other site 204669006403 Citrate synthase; Region: Citrate_synt; pfam00285 204669006404 active site 204669006405 citrylCoA binding site [chemical binding]; other site 204669006406 oxalacetate/citrate binding site [chemical binding]; other site 204669006407 coenzyme A binding site [chemical binding]; other site 204669006408 catalytic triad [active] 204669006409 Peptidase S46; Region: Peptidase_S46; pfam10459 204669006410 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 204669006411 hypothetical protein; Provisional; Region: PRK06489 204669006412 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 204669006413 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 204669006414 putative active site [active] 204669006415 putative metal binding site [ion binding]; other site 204669006416 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669006417 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 204669006418 dimer interface [polypeptide binding]; other site 204669006419 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669006420 ligand binding site [chemical binding]; other site 204669006421 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669006422 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 204669006423 active site 204669006424 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 204669006425 active site residue [active] 204669006426 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 204669006427 proposed catalytic triad [active] 204669006428 active site nucleophile [active] 204669006429 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 204669006430 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 204669006431 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 204669006432 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 204669006433 Ligand binding site; other site 204669006434 Putative Catalytic site; other site 204669006435 DXD motif; other site 204669006436 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 204669006437 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 204669006438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669006439 homodimer interface [polypeptide binding]; other site 204669006440 catalytic residue [active] 204669006441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669006442 S-adenosylmethionine binding site [chemical binding]; other site 204669006443 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 204669006444 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 204669006445 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 204669006446 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 204669006447 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 204669006448 molybdopterin cofactor binding site; other site 204669006449 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 204669006450 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 204669006451 amidase; Provisional; Region: PRK08137 204669006452 Amidase; Region: Amidase; cl11426 204669006453 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 204669006454 Sulfate transporter family; Region: Sulfate_transp; pfam00916 204669006455 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669006456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669006457 TPR motif; other site 204669006458 binding surface 204669006459 TPR repeat; Region: TPR_11; pfam13414 204669006460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669006461 binding surface 204669006462 TPR motif; other site 204669006463 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669006464 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 204669006465 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 204669006466 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 204669006467 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 204669006468 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 204669006469 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 204669006470 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 204669006471 Walker A/P-loop; other site 204669006472 ATP binding site [chemical binding]; other site 204669006473 Q-loop/lid; other site 204669006474 ABC transporter signature motif; other site 204669006475 Walker B; other site 204669006476 D-loop; other site 204669006477 H-loop/switch region; other site 204669006478 CcmE; Region: CcmE; cl00994 204669006479 Isochorismatase family; Region: Isochorismatase; pfam00857 204669006480 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 204669006481 catalytic triad [active] 204669006482 conserved cis-peptide bond; other site 204669006483 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 204669006484 ThiC family; Region: ThiC; pfam01964 204669006485 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 204669006486 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669006487 Catalytic domain of Protein Kinases; Region: PKc; cd00180 204669006488 active site 204669006489 ATP binding site [chemical binding]; other site 204669006490 substrate binding site [chemical binding]; other site 204669006491 activation loop (A-loop); other site 204669006492 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669006493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669006494 TPR motif; other site 204669006495 binding surface 204669006496 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669006497 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669006498 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669006499 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669006500 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669006501 Tetratricopeptide repeat; Region: TPR_10; pfam13374 204669006502 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 204669006503 DinB superfamily; Region: DinB_2; pfam12867 204669006504 DinB family; Region: DinB; cl17821 204669006505 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 204669006506 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669006507 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669006508 ligand binding site [chemical binding]; other site 204669006509 flexible hinge region; other site 204669006510 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 204669006511 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669006512 Coenzyme A binding pocket [chemical binding]; other site 204669006513 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 204669006514 intracellular protease, PfpI family; Region: PfpI; TIGR01382 204669006515 proposed catalytic triad [active] 204669006516 conserved cys residue [active] 204669006517 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 204669006518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669006519 ATP binding site [chemical binding]; other site 204669006520 Mg2+ binding site [ion binding]; other site 204669006521 G-X-G motif; other site 204669006522 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 204669006523 B12 binding domain; Region: B12-binding; pfam02310 204669006524 B12 binding site [chemical binding]; other site 204669006525 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669006526 FeS/SAM binding site; other site 204669006527 EamA-like transporter family; Region: EamA; cl17759 204669006528 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 204669006529 B12 binding domain; Region: B12-binding; pfam02310 204669006530 B12 binding site [chemical binding]; other site 204669006531 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 204669006532 Methyltransferase domain; Region: Methyltransf_31; pfam13847 204669006533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669006534 S-adenosylmethionine binding site [chemical binding]; other site 204669006535 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 204669006536 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 204669006537 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 204669006538 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 204669006539 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 204669006540 Predicted membrane protein [Function unknown]; Region: COG2860 204669006541 UPF0126 domain; Region: UPF0126; pfam03458 204669006542 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 204669006543 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669006544 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 204669006545 carbohydrate binding site [chemical binding]; other site 204669006546 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 204669006547 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 204669006548 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 204669006549 Ca binding site [ion binding]; other site 204669006550 active site 204669006551 catalytic site [active] 204669006552 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 204669006553 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 204669006554 aromatic arch; other site 204669006555 DCoH dimer interaction site [polypeptide binding]; other site 204669006556 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 204669006557 DCoH tetramer interaction site [polypeptide binding]; other site 204669006558 substrate binding site [chemical binding]; other site 204669006559 Uncharacterized conserved protein [Function unknown]; Region: COG2968 204669006560 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 204669006561 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 204669006562 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 204669006563 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 204669006564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669006565 FeS/SAM binding site; other site 204669006566 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 204669006567 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 204669006568 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669006569 Zn2+ binding site [ion binding]; other site 204669006570 Mg2+ binding site [ion binding]; other site 204669006571 peptide chain release factor 2; Validated; Region: prfB; PRK00578 204669006572 PCRF domain; Region: PCRF; pfam03462 204669006573 RF-1 domain; Region: RF-1; pfam00472 204669006574 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 204669006575 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 204669006576 putative active site [active] 204669006577 catalytic triad [active] 204669006578 putative dimer interface [polypeptide binding]; other site 204669006579 RibD C-terminal domain; Region: RibD_C; cl17279 204669006580 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 204669006581 Halocarboxylic acid dehydrogenase DehI; Region: DehI; pfam10778 204669006582 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 204669006583 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 204669006584 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 204669006585 trimer interface [polypeptide binding]; other site 204669006586 active site 204669006587 UDP-GlcNAc binding site [chemical binding]; other site 204669006588 lipid binding site [chemical binding]; lipid-binding site 204669006589 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 204669006590 putative acyl-acceptor binding pocket; other site 204669006591 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 204669006592 putative amphipathic alpha helix; other site 204669006593 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669006594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669006595 intermolecular recognition site; other site 204669006596 active site 204669006597 dimerization interface [polypeptide binding]; other site 204669006598 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669006599 DNA binding residues [nucleotide binding] 204669006600 dimerization interface [polypeptide binding]; other site 204669006601 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 204669006602 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 204669006603 NAD(P) binding site [chemical binding]; other site 204669006604 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 204669006605 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 204669006606 Asp-box motif; other site 204669006607 DinB superfamily; Region: DinB_2; pfam12867 204669006608 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 204669006609 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 204669006610 DNA polymerase III, delta subunit; Region: holA; TIGR01128 204669006611 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 204669006612 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 204669006613 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 204669006614 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 204669006615 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 204669006616 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669006617 Coenzyme A binding pocket [chemical binding]; other site 204669006618 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 204669006619 Glycoprotease family; Region: Peptidase_M22; pfam00814 204669006620 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669006621 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 204669006622 dimer interface [polypeptide binding]; other site 204669006623 substrate binding site [chemical binding]; other site 204669006624 metal binding site [ion binding]; metal-binding site 204669006625 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 204669006626 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 204669006627 Walker A; other site 204669006628 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 204669006629 G4 box; other site 204669006630 G5 box; other site 204669006631 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 204669006632 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669006633 FeS/SAM binding site; other site 204669006634 HemN C-terminal domain; Region: HemN_C; pfam06969 204669006635 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 204669006636 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 204669006637 tetramer interface [polypeptide binding]; other site 204669006638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669006639 catalytic residue [active] 204669006640 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 204669006641 putative hydrophobic ligand binding site [chemical binding]; other site 204669006642 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 204669006643 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 204669006644 FAD binding site [chemical binding]; other site 204669006645 homotetramer interface [polypeptide binding]; other site 204669006646 substrate binding pocket [chemical binding]; other site 204669006647 catalytic base [active] 204669006648 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 204669006649 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 204669006650 dimer interface [polypeptide binding]; other site 204669006651 active site 204669006652 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 204669006653 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 204669006654 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 204669006655 Walker A/P-loop; other site 204669006656 ATP binding site [chemical binding]; other site 204669006657 Q-loop/lid; other site 204669006658 ABC transporter signature motif; other site 204669006659 Walker B; other site 204669006660 D-loop; other site 204669006661 H-loop/switch region; other site 204669006662 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 204669006663 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 204669006664 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 204669006665 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 204669006666 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 204669006667 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 204669006668 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 204669006669 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 204669006670 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 204669006671 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 204669006672 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 204669006673 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 204669006674 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 204669006675 active site 204669006676 SAM binding site [chemical binding]; other site 204669006677 homodimer interface [polypeptide binding]; other site 204669006678 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 204669006679 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 204669006680 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669006681 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 204669006682 active site 204669006683 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 204669006684 PA14 domain; Region: PA14; cl08459 204669006685 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 204669006686 H+ Antiporter protein; Region: 2A0121; TIGR00900 204669006687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669006688 putative substrate translocation pore; other site 204669006689 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 204669006690 active site 204669006691 dimer interfaces [polypeptide binding]; other site 204669006692 catalytic residues [active] 204669006693 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 204669006694 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 204669006695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669006696 Coenzyme A binding pocket [chemical binding]; other site 204669006697 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 204669006698 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 204669006699 catalytic residues [active] 204669006700 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 204669006701 active site 204669006702 zinc binding site [ion binding]; other site 204669006703 Transcriptional regulators [Transcription]; Region: PurR; COG1609 204669006704 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 204669006705 domain linker motif; other site 204669006706 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 204669006707 ligand binding site [chemical binding]; other site 204669006708 dimerization interface [polypeptide binding]; other site 204669006709 Fn3 associated; Region: Fn3_assoc; pfam13287 204669006710 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 204669006711 active site 204669006712 catalytic residues [active] 204669006713 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669006714 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669006715 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 204669006716 hypothetical protein; Provisional; Region: PRK08609 204669006717 active site 204669006718 primer binding site [nucleotide binding]; other site 204669006719 NTP binding site [chemical binding]; other site 204669006720 metal binding triad [ion binding]; metal-binding site 204669006721 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 204669006722 active site 204669006723 Intra-flagellar transport protein 57; Region: IFT57; pfam10498 204669006724 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 204669006725 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 204669006726 short chain dehydrogenase; Provisional; Region: PRK06914 204669006727 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 204669006728 NADP binding site [chemical binding]; other site 204669006729 active site 204669006730 steroid binding site; other site 204669006731 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 204669006732 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 204669006733 active site 204669006734 FMN binding site [chemical binding]; other site 204669006735 substrate binding site [chemical binding]; other site 204669006736 homotetramer interface [polypeptide binding]; other site 204669006737 catalytic residue [active] 204669006738 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669006739 Catalytic domain of Protein Kinases; Region: PKc; cd00180 204669006740 active site 204669006741 ATP binding site [chemical binding]; other site 204669006742 substrate binding site [chemical binding]; other site 204669006743 activation loop (A-loop); other site 204669006744 Predicted integral membrane protein [Function unknown]; Region: COG5616 204669006745 TPR repeat; Region: TPR_11; pfam13414 204669006746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669006747 TPR motif; other site 204669006748 TPR repeat; Region: TPR_11; pfam13414 204669006749 binding surface 204669006750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669006751 TPR motif; other site 204669006752 TPR repeat; Region: TPR_11; pfam13414 204669006753 binding surface 204669006754 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 204669006755 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 204669006756 short chain dehydrogenase; Provisional; Region: PRK05650 204669006757 classical (c) SDRs; Region: SDR_c; cd05233 204669006758 NAD(P) binding site [chemical binding]; other site 204669006759 active site 204669006760 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 204669006761 GAF domain; Region: GAF_3; pfam13492 204669006762 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669006763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669006764 dimer interface [polypeptide binding]; other site 204669006765 phosphorylation site [posttranslational modification] 204669006766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669006767 ATP binding site [chemical binding]; other site 204669006768 Mg2+ binding site [ion binding]; other site 204669006769 G-X-G motif; other site 204669006770 Response regulator receiver domain; Region: Response_reg; pfam00072 204669006771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669006772 active site 204669006773 phosphorylation site [posttranslational modification] 204669006774 intermolecular recognition site; other site 204669006775 dimerization interface [polypeptide binding]; other site 204669006776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669006777 heme pocket [chemical binding]; other site 204669006778 putative active site [active] 204669006779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669006780 dimer interface [polypeptide binding]; other site 204669006781 phosphorylation site [posttranslational modification] 204669006782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669006783 ATP binding site [chemical binding]; other site 204669006784 Mg2+ binding site [ion binding]; other site 204669006785 G-X-G motif; other site 204669006786 Gas vesicle protein G; Region: GvpG; pfam05120 204669006787 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 204669006788 Response regulator receiver domain; Region: Response_reg; pfam00072 204669006789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669006790 active site 204669006791 phosphorylation site [posttranslational modification] 204669006792 intermolecular recognition site; other site 204669006793 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 204669006794 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 204669006795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669006796 dimer interface [polypeptide binding]; other site 204669006797 phosphorylation site [posttranslational modification] 204669006798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669006799 ATP binding site [chemical binding]; other site 204669006800 Mg2+ binding site [ion binding]; other site 204669006801 G-X-G motif; other site 204669006802 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 204669006803 Gas vesicle protein; Region: Gas_vesicle; pfam00741 204669006804 Gas vesicle protein K; Region: GvpK; pfam05121 204669006805 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 204669006806 Gas vesicle protein; Region: Gas_vesicle; pfam00741 204669006807 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 204669006808 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 204669006809 DTAP/Switch II; other site 204669006810 Switch I; other site 204669006811 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 204669006812 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 204669006813 DTAP/Switch II; other site 204669006814 Switch I; other site 204669006815 Response regulator receiver domain; Region: Response_reg; pfam00072 204669006816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669006817 active site 204669006818 phosphorylation site [posttranslational modification] 204669006819 intermolecular recognition site; other site 204669006820 dimerization interface [polypeptide binding]; other site 204669006821 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 204669006822 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669006823 putative active site [active] 204669006824 heme pocket [chemical binding]; other site 204669006825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669006826 dimer interface [polypeptide binding]; other site 204669006827 phosphorylation site [posttranslational modification] 204669006828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669006829 ATP binding site [chemical binding]; other site 204669006830 Mg2+ binding site [ion binding]; other site 204669006831 G-X-G motif; other site 204669006832 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 204669006833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669006834 ATP binding site [chemical binding]; other site 204669006835 Mg2+ binding site [ion binding]; other site 204669006836 G-X-G motif; other site 204669006837 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 204669006838 dimer interface [polypeptide binding]; other site 204669006839 phosphorylation site [posttranslational modification] 204669006840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669006841 ATP binding site [chemical binding]; other site 204669006842 Mg2+ binding site [ion binding]; other site 204669006843 G-X-G motif; other site 204669006844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669006845 active site 204669006846 phosphorylation site [posttranslational modification] 204669006847 intermolecular recognition site; other site 204669006848 dimerization interface [polypeptide binding]; other site 204669006849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 204669006850 ATP binding site [chemical binding]; other site 204669006851 Mg2+ binding site [ion binding]; other site 204669006852 G-X-G motif; other site 204669006853 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 204669006854 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 204669006855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669006856 ATP binding site [chemical binding]; other site 204669006857 Mg2+ binding site [ion binding]; other site 204669006858 G-X-G motif; other site 204669006859 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 204669006860 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 204669006861 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 204669006862 CAAX protease self-immunity; Region: Abi; pfam02517 204669006863 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 204669006864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 204669006865 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 204669006866 5'-3' exonuclease; Region: 53EXOc; smart00475 204669006867 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 204669006868 active site 204669006869 metal binding site 1 [ion binding]; metal-binding site 204669006870 putative 5' ssDNA interaction site; other site 204669006871 metal binding site 3; metal-binding site 204669006872 metal binding site 2 [ion binding]; metal-binding site 204669006873 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 204669006874 putative DNA binding site [nucleotide binding]; other site 204669006875 putative metal binding site [ion binding]; other site 204669006876 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 204669006877 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 204669006878 HipA N-terminal domain; Region: Couple_hipA; cl11853 204669006879 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 204669006880 HipA-like N-terminal domain; Region: HipA_N; pfam07805 204669006881 HipA-like C-terminal domain; Region: HipA_C; pfam07804 204669006882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669006883 non-specific DNA binding site [nucleotide binding]; other site 204669006884 salt bridge; other site 204669006885 sequence-specific DNA binding site [nucleotide binding]; other site 204669006886 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 204669006887 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 204669006888 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 204669006889 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 204669006890 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669006891 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669006892 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 204669006893 N-terminal plug; other site 204669006894 ligand-binding site [chemical binding]; other site 204669006895 putative oligopeptide transporter, OPT family; Region: TIGR00733 204669006896 OPT oligopeptide transporter protein; Region: OPT; pfam03169 204669006897 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669006898 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669006899 ligand binding site [chemical binding]; other site 204669006900 flexible hinge region; other site 204669006901 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 204669006902 peptidase domain interface [polypeptide binding]; other site 204669006903 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 204669006904 active site 204669006905 catalytic triad [active] 204669006906 calcium binding site [ion binding]; other site 204669006907 TPR repeat; Region: TPR_11; pfam13414 204669006908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669006909 binding surface 204669006910 TPR motif; other site 204669006911 TPR repeat; Region: TPR_11; pfam13414 204669006912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669006913 TPR motif; other site 204669006914 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 204669006915 binding surface 204669006916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669006917 binding surface 204669006918 TPR motif; other site 204669006919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669006920 binding surface 204669006921 TPR motif; other site 204669006922 Cupin domain; Region: Cupin_2; pfam07883 204669006923 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 204669006924 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 204669006925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 204669006926 Histidine kinase; Region: HisKA_3; pfam07730 204669006927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669006928 ATP binding site [chemical binding]; other site 204669006929 Mg2+ binding site [ion binding]; other site 204669006930 G-X-G motif; other site 204669006931 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669006932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669006933 active site 204669006934 phosphorylation site [posttranslational modification] 204669006935 intermolecular recognition site; other site 204669006936 dimerization interface [polypeptide binding]; other site 204669006937 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669006938 DNA binding residues [nucleotide binding] 204669006939 dimerization interface [polypeptide binding]; other site 204669006940 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 204669006941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669006942 active site 204669006943 phosphorylation site [posttranslational modification] 204669006944 intermolecular recognition site; other site 204669006945 dimerization interface [polypeptide binding]; other site 204669006946 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669006947 DNA binding residues [nucleotide binding] 204669006948 dimerization interface [polypeptide binding]; other site 204669006949 DJ-1 family protein; Region: not_thiJ; TIGR01383 204669006950 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 204669006951 conserved cys residue [active] 204669006952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 204669006953 Transposase; Region: DEDD_Tnp_IS110; pfam01548 204669006954 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 204669006955 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 204669006956 catalytic motif [active] 204669006957 Catalytic residue [active] 204669006958 Aspartyl protease; Region: Asp_protease_2; pfam13650 204669006959 inhibitor binding site; inhibition site 204669006960 catalytic motif [active] 204669006961 Catalytic residue [active] 204669006962 Active site flap [active] 204669006963 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 204669006964 CARDB; Region: CARDB; pfam07705 204669006965 CARDB; Region: CARDB; pfam07705 204669006966 CARDB; Region: CARDB; pfam07705 204669006967 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 204669006968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669006969 Coenzyme A binding pocket [chemical binding]; other site 204669006970 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 204669006971 Phage Tail Collar Domain; Region: Collar; pfam07484 204669006972 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 204669006973 Phage Tail Collar Domain; Region: Collar; pfam07484 204669006974 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 204669006975 Phage Tail Collar Domain; Region: Collar; pfam07484 204669006976 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 204669006977 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 204669006978 tetramer interface [polypeptide binding]; other site 204669006979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669006980 catalytic residue [active] 204669006981 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 204669006982 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 204669006983 tetramer interface [polypeptide binding]; other site 204669006984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669006985 catalytic residue [active] 204669006986 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 204669006987 lipoyl attachment site [posttranslational modification]; other site 204669006988 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 204669006989 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 204669006990 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 204669006991 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 204669006992 Response regulator receiver domain; Region: Response_reg; pfam00072 204669006993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669006994 active site 204669006995 phosphorylation site [posttranslational modification] 204669006996 intermolecular recognition site; other site 204669006997 dimerization interface [polypeptide binding]; other site 204669006998 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 204669006999 putative amphipathic alpha helix; other site 204669007000 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 204669007001 RibD C-terminal domain; Region: RibD_C; cl17279 204669007002 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 204669007003 PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121 204669007004 apical/protease domain interface [polypeptide binding]; other site 204669007005 substrate binding [chemical binding]; other site 204669007006 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 204669007007 dimer interface [polypeptide binding]; other site 204669007008 M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022 204669007009 dimer interface [polypeptide binding]; other site 204669007010 Peptidase family M28; Region: Peptidase_M28; pfam04389 204669007011 active site 204669007012 metal binding site [ion binding]; metal-binding site 204669007013 Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253 204669007014 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 204669007015 active site 204669007016 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 204669007017 nucleophile elbow; other site 204669007018 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 204669007019 active site 204669007020 Ap6A binding site [chemical binding]; other site 204669007021 nudix motif; other site 204669007022 metal binding site [ion binding]; metal-binding site 204669007023 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 204669007024 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 204669007025 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 204669007026 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 204669007027 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 204669007028 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 204669007029 substrate binding site [chemical binding]; other site 204669007030 oxyanion hole (OAH) forming residues; other site 204669007031 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 204669007032 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 204669007033 dimer interface [polypeptide binding]; other site 204669007034 active site 204669007035 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 204669007036 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 204669007037 active site 204669007038 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 204669007039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 204669007040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669007041 Family of unknown function (DUF490); Region: DUF490; pfam04357 204669007042 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669007043 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669007044 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 204669007045 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669007046 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669007047 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669007048 Surface antigen; Region: Bac_surface_Ag; pfam01103 204669007049 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 204669007050 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 204669007051 ATP binding site [chemical binding]; other site 204669007052 substrate interface [chemical binding]; other site 204669007053 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669007054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669007055 active site 204669007056 phosphorylation site [posttranslational modification] 204669007057 intermolecular recognition site; other site 204669007058 dimerization interface [polypeptide binding]; other site 204669007059 RibD C-terminal domain; Region: RibD_C; cl17279 204669007060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669007061 Major Facilitator Superfamily; Region: MFS_1; pfam07690 204669007062 putative substrate translocation pore; other site 204669007063 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 204669007064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669007065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669007066 DNA binding residues [nucleotide binding] 204669007067 shikimate kinase; Reviewed; Region: aroK; PRK00131 204669007068 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 204669007069 ADP binding site [chemical binding]; other site 204669007070 magnesium binding site [ion binding]; other site 204669007071 putative shikimate binding site; other site 204669007072 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 204669007073 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 204669007074 aspartate kinase III; Validated; Region: PRK09084 204669007075 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 204669007076 putative catalytic residues [active] 204669007077 nucleotide binding site [chemical binding]; other site 204669007078 aspartate binding site [chemical binding]; other site 204669007079 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 204669007080 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 204669007081 dihydrodipicolinate reductase; Provisional; Region: PRK00048 204669007082 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 204669007083 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 204669007084 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 204669007085 dihydrodipicolinate synthase; Region: dapA; TIGR00674 204669007086 dimer interface [polypeptide binding]; other site 204669007087 active site 204669007088 catalytic residue [active] 204669007089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669007090 TPR motif; other site 204669007091 binding surface 204669007092 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 204669007093 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669007094 DNA binding residues [nucleotide binding] 204669007095 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669007096 PAS domain; Region: PAS_9; pfam13426 204669007097 putative active site [active] 204669007098 heme pocket [chemical binding]; other site 204669007099 GAF domain; Region: GAF; pfam01590 204669007100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669007101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669007102 dimer interface [polypeptide binding]; other site 204669007103 phosphorylation site [posttranslational modification] 204669007104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669007105 ATP binding site [chemical binding]; other site 204669007106 Mg2+ binding site [ion binding]; other site 204669007107 G-X-G motif; other site 204669007108 Response regulator receiver domain; Region: Response_reg; pfam00072 204669007109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669007110 active site 204669007111 phosphorylation site [posttranslational modification] 204669007112 intermolecular recognition site; other site 204669007113 dimerization interface [polypeptide binding]; other site 204669007114 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 204669007115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669007116 active site 204669007117 phosphorylation site [posttranslational modification] 204669007118 intermolecular recognition site; other site 204669007119 dimerization interface [polypeptide binding]; other site 204669007120 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669007121 Zn2+ binding site [ion binding]; other site 204669007122 Mg2+ binding site [ion binding]; other site 204669007123 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 204669007124 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 204669007125 homodimer interface [polypeptide binding]; other site 204669007126 substrate-cofactor binding pocket; other site 204669007127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669007128 catalytic residue [active] 204669007129 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 204669007130 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 204669007131 dimer interface [polypeptide binding]; other site 204669007132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669007133 catalytic residue [active] 204669007134 short chain dehydrogenase; Provisional; Region: PRK06180 204669007135 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 204669007136 NADP binding site [chemical binding]; other site 204669007137 active site 204669007138 steroid binding site; other site 204669007139 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cl12263 204669007140 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669007141 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 204669007142 metal ion-dependent adhesion site (MIDAS); other site 204669007143 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669007144 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 204669007145 metal ion-dependent adhesion site (MIDAS); other site 204669007146 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 204669007147 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 204669007148 active site 204669007149 metal binding site [ion binding]; metal-binding site 204669007150 Sporulation and spore germination; Region: Germane; pfam10646 204669007151 glutamate racemase; Provisional; Region: PRK00865 204669007152 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 204669007153 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 204669007154 active site 1 [active] 204669007155 dimer interface [polypeptide binding]; other site 204669007156 hexamer interface [polypeptide binding]; other site 204669007157 active site 2 [active] 204669007158 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 204669007159 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 204669007160 active site 204669007161 catalytic tetrad [active] 204669007162 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 204669007163 Helix-hairpin-helix motif; Region: HHH; pfam00633 204669007164 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 204669007165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 204669007166 Mg2+ binding site [ion binding]; other site 204669007167 G-X-G motif; other site 204669007168 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 204669007169 anti sigma factor interaction site; other site 204669007170 regulatory phosphorylation site [posttranslational modification]; other site 204669007171 Double zinc ribbon; Region: DZR; pfam12773 204669007172 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 204669007173 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 204669007174 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 204669007175 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 204669007176 Ca binding site [ion binding]; other site 204669007177 active site 204669007178 catalytic site [active] 204669007179 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 204669007180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 204669007181 motif II; other site 204669007182 TPR repeat; Region: TPR_11; pfam13414 204669007183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669007184 binding surface 204669007185 TPR motif; other site 204669007186 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 204669007187 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 204669007188 Disulfide bond isomerase protein N-terminus; Region: DsbC_N; pfam10411 204669007189 Thioredoxin; Region: Thioredoxin_4; cl17273 204669007190 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 204669007191 NAD synthetase; Provisional; Region: PRK13981 204669007192 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 204669007193 multimer interface [polypeptide binding]; other site 204669007194 active site 204669007195 catalytic triad [active] 204669007196 protein interface 1 [polypeptide binding]; other site 204669007197 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 204669007198 homodimer interface [polypeptide binding]; other site 204669007199 NAD binding pocket [chemical binding]; other site 204669007200 ATP binding pocket [chemical binding]; other site 204669007201 Mg binding site [ion binding]; other site 204669007202 active-site loop [active] 204669007203 Response regulator receiver domain; Region: Response_reg; pfam00072 204669007204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669007205 active site 204669007206 phosphorylation site [posttranslational modification] 204669007207 intermolecular recognition site; other site 204669007208 dimerization interface [polypeptide binding]; other site 204669007209 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 204669007210 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 204669007211 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 204669007212 TPR motif; other site 204669007213 binding surface 204669007214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669007215 binding surface 204669007216 TPR motif; other site 204669007217 TPR repeat; Region: TPR_11; pfam13414 204669007218 TPR repeat; Region: TPR_11; pfam13414 204669007219 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 204669007220 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 204669007221 dimer interface [polypeptide binding]; other site 204669007222 active site residues [active] 204669007223 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 204669007224 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 204669007225 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 204669007226 Sporulation related domain; Region: SPOR; pfam05036 204669007227 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 204669007228 dimerization interface [polypeptide binding]; other site 204669007229 putative DNA binding site [nucleotide binding]; other site 204669007230 putative Zn2+ binding site [ion binding]; other site 204669007231 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 204669007232 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 204669007233 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 204669007234 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 204669007235 Zn binding site [ion binding]; other site 204669007236 TPR repeat; Region: TPR_11; pfam13414 204669007237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669007238 TPR motif; other site 204669007239 binding surface 204669007240 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669007241 AAA domain; Region: AAA_33; pfam13671 204669007242 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 204669007243 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 204669007244 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 204669007245 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 204669007246 Phosphoglycerate kinase; Region: PGK; pfam00162 204669007247 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 204669007248 substrate binding site [chemical binding]; other site 204669007249 hinge regions; other site 204669007250 ADP binding site [chemical binding]; other site 204669007251 catalytic site [active] 204669007252 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 204669007253 putative ADP-ribose binding site [chemical binding]; other site 204669007254 putative active site [active] 204669007255 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 204669007256 triosephosphate isomerase; Provisional; Region: PRK14565 204669007257 substrate binding site [chemical binding]; other site 204669007258 dimer interface [polypeptide binding]; other site 204669007259 catalytic triad [active] 204669007260 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 204669007261 dimerization interface [polypeptide binding]; other site 204669007262 metal binding site [ion binding]; metal-binding site 204669007263 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 204669007264 Outer membrane efflux protein; Region: OEP; pfam02321 204669007265 Outer membrane efflux protein; Region: OEP; pfam02321 204669007266 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 204669007267 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 204669007268 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669007269 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 204669007270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669007271 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 204669007272 putative active site [active] 204669007273 heme pocket [chemical binding]; other site 204669007274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669007275 dimer interface [polypeptide binding]; other site 204669007276 phosphorylation site [posttranslational modification] 204669007277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669007278 ATP binding site [chemical binding]; other site 204669007279 Mg2+ binding site [ion binding]; other site 204669007280 G-X-G motif; other site 204669007281 Response regulator receiver domain; Region: Response_reg; pfam00072 204669007282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669007283 active site 204669007284 phosphorylation site [posttranslational modification] 204669007285 intermolecular recognition site; other site 204669007286 dimerization interface [polypeptide binding]; other site 204669007287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669007288 TPR motif; other site 204669007289 binding surface 204669007290 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669007291 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669007292 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669007293 Amidohydrolase; Region: Amidohydro_4; pfam13147 204669007294 active site 204669007295 putative sialic acid transporter; Region: 2A0112; TIGR00891 204669007296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669007297 putative substrate translocation pore; other site 204669007298 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 204669007299 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 204669007300 active site 204669007301 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 204669007302 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 204669007303 active site 204669007304 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 204669007305 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 204669007306 domain interfaces; other site 204669007307 active site 204669007308 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 204669007309 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 204669007310 tRNA; other site 204669007311 putative tRNA binding site [nucleotide binding]; other site 204669007312 putative NADP binding site [chemical binding]; other site 204669007313 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 204669007314 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 204669007315 Peptidase family M48; Region: Peptidase_M48; pfam01435 204669007316 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 204669007317 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 204669007318 putative Iron-sulfur protein interface [polypeptide binding]; other site 204669007319 proximal heme binding site [chemical binding]; other site 204669007320 distal heme binding site [chemical binding]; other site 204669007321 putative dimer interface [polypeptide binding]; other site 204669007322 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 204669007323 L-aspartate oxidase; Provisional; Region: PRK06175 204669007324 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 204669007325 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 204669007326 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 204669007327 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 204669007328 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669007329 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669007330 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669007331 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669007332 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 204669007333 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669007334 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669007335 active site 204669007336 ATP binding site [chemical binding]; other site 204669007337 substrate binding site [chemical binding]; other site 204669007338 activation loop (A-loop); other site 204669007339 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 204669007340 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 204669007341 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 204669007342 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 204669007343 active site 204669007344 dimer interface [polypeptide binding]; other site 204669007345 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 204669007346 active site 204669007347 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 204669007348 putative active site [active] 204669007349 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 204669007350 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 204669007351 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 204669007352 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 204669007353 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 204669007354 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 204669007355 SLBB domain; Region: SLBB; pfam10531 204669007356 YdjC-family proteins; Region: YdjC_like; cd10788 204669007357 putative active site [active] 204669007358 YdjC motif; other site 204669007359 Mg binding site [ion binding]; other site 204669007360 putative homodimer interface [polypeptide binding]; other site 204669007361 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 204669007362 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 204669007363 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 204669007364 O-Antigen ligase; Region: Wzy_C; pfam04932 204669007365 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 204669007366 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 204669007367 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 204669007368 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 204669007369 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 204669007370 Protein of unknown function (DUF354); Region: DUF354; pfam04007 204669007371 Bacterial sugar transferase; Region: Bac_transf; pfam02397 204669007372 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 204669007373 dimer interface [polypeptide binding]; other site 204669007374 substrate binding site [chemical binding]; other site 204669007375 ATP binding site [chemical binding]; other site 204669007376 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 204669007377 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 204669007378 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 204669007379 active site 204669007380 dimer interface [polypeptide binding]; other site 204669007381 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 204669007382 Peptidase family M50; Region: Peptidase_M50; pfam02163 204669007383 active site 204669007384 putative substrate binding region [chemical binding]; other site 204669007385 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 204669007386 catalytic residue [active] 204669007387 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 204669007388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669007389 Coenzyme A binding pocket [chemical binding]; other site 204669007390 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 204669007391 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 204669007392 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 204669007393 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 204669007394 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 204669007395 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 204669007396 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669007397 dimerization interface [polypeptide binding]; other site 204669007398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669007399 dimer interface [polypeptide binding]; other site 204669007400 phosphorylation site [posttranslational modification] 204669007401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669007402 ATP binding site [chemical binding]; other site 204669007403 Mg2+ binding site [ion binding]; other site 204669007404 G-X-G motif; other site 204669007405 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669007406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669007407 active site 204669007408 phosphorylation site [posttranslational modification] 204669007409 intermolecular recognition site; other site 204669007410 dimerization interface [polypeptide binding]; other site 204669007411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669007412 Walker A motif; other site 204669007413 ATP binding site [chemical binding]; other site 204669007414 Walker B motif; other site 204669007415 arginine finger; other site 204669007416 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669007417 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375 204669007418 active site 204669007419 Zn binding site [ion binding]; other site 204669007420 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 204669007421 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 204669007422 putative DNA binding site [nucleotide binding]; other site 204669007423 putative homodimer interface [polypeptide binding]; other site 204669007424 Integral membrane protein DUF92; Region: DUF92; pfam01940 204669007425 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 204669007426 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 204669007427 active site 204669007428 putative substrate binding pocket [chemical binding]; other site 204669007429 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669007430 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669007431 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 204669007432 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 204669007433 putative active site [active] 204669007434 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 204669007435 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 204669007436 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 204669007437 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 204669007438 recombination factor protein RarA; Reviewed; Region: PRK13342 204669007439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669007440 Walker A motif; other site 204669007441 ATP binding site [chemical binding]; other site 204669007442 Walker B motif; other site 204669007443 arginine finger; other site 204669007444 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 204669007445 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 204669007446 Beta-lactamase; Region: Beta-lactamase; pfam00144 204669007447 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 204669007448 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 204669007449 Beta-lactamase; Region: Beta-lactamase; cl17358 204669007450 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 204669007451 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 204669007452 putative active site [active] 204669007453 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 204669007454 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 204669007455 putative acyl-acceptor binding pocket; other site 204669007456 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 204669007457 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 204669007458 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 204669007459 protein binding site [polypeptide binding]; other site 204669007460 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 204669007461 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 204669007462 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 204669007463 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 204669007464 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 204669007465 dimer interface [polypeptide binding]; other site 204669007466 catalytic triad [active] 204669007467 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 204669007468 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 204669007469 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 204669007470 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 204669007471 MgtC family; Region: MgtC; pfam02308 204669007472 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 204669007473 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 204669007474 substrate binding site [chemical binding]; other site 204669007475 ATP binding site [chemical binding]; other site 204669007476 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 204669007477 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 204669007478 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 204669007479 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 204669007480 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 204669007481 putative hydrolase; Provisional; Region: PRK02113 204669007482 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 204669007483 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 204669007484 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 204669007485 active site 204669007486 Riboflavin kinase; Region: Flavokinase; pfam01687 204669007487 putative sialic acid transporter; Provisional; Region: PRK12307 204669007488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669007489 putative substrate translocation pore; other site 204669007490 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 204669007491 EamA-like transporter family; Region: EamA; pfam00892 204669007492 EamA-like transporter family; Region: EamA; pfam00892 204669007493 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 204669007494 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 204669007495 active site 204669007496 catalytic triad [active] 204669007497 calcium binding site [ion binding]; other site 204669007498 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 204669007499 putative active site [active] 204669007500 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 204669007501 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 204669007502 Walker A/P-loop; other site 204669007503 ATP binding site [chemical binding]; other site 204669007504 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 204669007505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669007506 Q-loop/lid; other site 204669007507 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 204669007508 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 204669007509 ABC transporter signature motif; other site 204669007510 Walker B; other site 204669007511 D-loop; other site 204669007512 H-loop/switch region; other site 204669007513 Predicted esterase [General function prediction only]; Region: COG0400 204669007514 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 204669007515 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 204669007516 Galactose oxidase, central domain; Region: Kelch_3; cl02701 204669007517 Kelch domain; Region: Kelch; smart00612 204669007518 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 204669007519 Galactose oxidase, central domain; Region: Kelch_3; cl02701 204669007520 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 204669007521 Kelch domain; Region: Kelch; smart00612 204669007522 H+ Antiporter protein; Region: 2A0121; TIGR00900 204669007523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669007524 putative substrate translocation pore; other site 204669007525 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 204669007526 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 204669007527 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 204669007528 putative NAD(P) binding site [chemical binding]; other site 204669007529 structural Zn binding site [ion binding]; other site 204669007530 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 204669007531 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 204669007532 XdhC Rossmann domain; Region: XdhC_C; pfam13478 204669007533 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 204669007534 Ligand binding site; other site 204669007535 metal-binding site 204669007536 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 204669007537 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 204669007538 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 204669007539 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669007540 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 204669007541 trimerization site [polypeptide binding]; other site 204669007542 active site 204669007543 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 204669007544 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 204669007545 intersubunit interface [polypeptide binding]; other site 204669007546 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 204669007547 GAF domain; Region: GAF_2; pfam13185 204669007548 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 204669007549 active site 204669007550 8-oxo-dGMP binding site [chemical binding]; other site 204669007551 nudix motif; other site 204669007552 metal binding site [ion binding]; metal-binding site 204669007553 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 204669007554 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 204669007555 MgtE intracellular N domain; Region: MgtE_N; pfam03448 204669007556 FOG: CBS domain [General function prediction only]; Region: COG0517 204669007557 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 204669007558 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 204669007559 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 204669007560 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 204669007561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 204669007562 MOSC domain; Region: MOSC; pfam03473 204669007563 3-alpha domain; Region: 3-alpha; pfam03475 204669007564 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 204669007565 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 204669007566 FAD binding pocket [chemical binding]; other site 204669007567 FAD binding motif [chemical binding]; other site 204669007568 phosphate binding motif [ion binding]; other site 204669007569 beta-alpha-beta structure motif; other site 204669007570 NAD binding pocket [chemical binding]; other site 204669007571 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 204669007572 catalytic loop [active] 204669007573 iron binding site [ion binding]; other site 204669007574 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 204669007575 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 204669007576 active site 204669007577 catalytic tetrad [active] 204669007578 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 204669007579 dinuclear metal binding motif [ion binding]; other site 204669007580 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 204669007581 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 204669007582 heme-binding residues [chemical binding]; other site 204669007583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669007584 TPR motif; other site 204669007585 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669007586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669007587 TPR motif; other site 204669007588 binding surface 204669007589 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669007590 PEGA domain; Region: PEGA; pfam08308 204669007591 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 204669007592 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 204669007593 inhibitor site; inhibition site 204669007594 active site 204669007595 dimer interface [polypeptide binding]; other site 204669007596 catalytic residue [active] 204669007597 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 204669007598 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669007599 Transglycosylase; Region: Transgly; cl17702 204669007600 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 204669007601 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 204669007602 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 204669007603 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 204669007604 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 204669007605 DinB superfamily; Region: DinB_2; pfam12867 204669007606 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 204669007607 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 204669007608 Na binding site [ion binding]; other site 204669007609 Predicted membrane protein [Function unknown]; Region: COG4244 204669007610 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 204669007611 [2Fe-2S] cluster binding site [ion binding]; other site 204669007612 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669007613 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669007614 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669007615 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 204669007616 C-terminal peptidase (prc); Region: prc; TIGR00225 204669007617 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 204669007618 protein binding site [polypeptide binding]; other site 204669007619 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 204669007620 Catalytic dyad [active] 204669007621 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 204669007622 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 204669007623 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 204669007624 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 204669007625 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 204669007626 Peptidase family M28; Region: Peptidase_M28; pfam04389 204669007627 metal binding site [ion binding]; metal-binding site 204669007628 Catalytic domain of Protein Kinases; Region: PKc; cd00180 204669007629 active site 204669007630 ATP binding site [chemical binding]; other site 204669007631 Protein kinase domain; Region: Pkinase; pfam00069 204669007632 substrate binding site [chemical binding]; other site 204669007633 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669007634 substrate binding site [chemical binding]; other site 204669007635 activation loop (A-loop); other site 204669007636 activation loop (A-loop); other site 204669007637 PEGA domain; Region: PEGA; pfam08308 204669007638 PEGA domain; Region: PEGA; pfam08308 204669007639 PEGA domain; Region: PEGA; pfam08308 204669007640 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 204669007641 ligand binding site [chemical binding]; other site 204669007642 putative catalytic site [active] 204669007643 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 204669007644 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cl00238 204669007645 putative iron binding site [ion binding]; other site 204669007646 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 204669007647 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 204669007648 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 204669007649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669007650 binding surface 204669007651 TPR motif; other site 204669007652 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 204669007653 Aspartase; Region: Aspartase; cd01357 204669007654 active sites [active] 204669007655 tetramer interface [polypeptide binding]; other site 204669007656 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 204669007657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669007658 binding surface 204669007659 TPR motif; other site 204669007660 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 204669007661 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 204669007662 N-acetyl-D-glucosamine binding site [chemical binding]; other site 204669007663 catalytic residue [active] 204669007664 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 204669007665 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 204669007666 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 204669007667 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669007668 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669007669 DNA binding residues [nucleotide binding] 204669007670 Putative zinc-finger; Region: zf-HC2; pfam13490 204669007671 ADP-glucose phosphorylase; Region: PLN02643 204669007672 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 204669007673 nucleotide binding site/active site [active] 204669007674 HIT family signature motif; other site 204669007675 catalytic residue [active] 204669007676 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 204669007677 MutS domain I; Region: MutS_I; pfam01624 204669007678 MutS domain II; Region: MutS_II; pfam05188 204669007679 MutS domain III; Region: MutS_III; pfam05192 204669007680 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 204669007681 Walker A/P-loop; other site 204669007682 ATP binding site [chemical binding]; other site 204669007683 Q-loop/lid; other site 204669007684 ABC transporter signature motif; other site 204669007685 Walker B; other site 204669007686 D-loop; other site 204669007687 H-loop/switch region; other site 204669007688 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 204669007689 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 204669007690 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669007691 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669007692 ligand binding site [chemical binding]; other site 204669007693 flexible hinge region; other site 204669007694 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 204669007695 putative switch regulator; other site 204669007696 non-specific DNA interactions [nucleotide binding]; other site 204669007697 DNA binding site [nucleotide binding] 204669007698 sequence specific DNA binding site [nucleotide binding]; other site 204669007699 putative cAMP binding site [chemical binding]; other site 204669007700 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669007701 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 204669007702 ligand binding site [chemical binding]; other site 204669007703 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 204669007704 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 204669007705 Sulfatase; Region: Sulfatase; cl17466 204669007706 YwiC-like protein; Region: YwiC; pfam14256 204669007707 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 204669007708 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669007709 FeS/SAM binding site; other site 204669007710 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 204669007711 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 204669007712 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 204669007713 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 204669007714 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 204669007715 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 204669007716 heme-binding residues [chemical binding]; other site 204669007717 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 204669007718 heme-binding residues [chemical binding]; other site 204669007719 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 204669007720 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 204669007721 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669007722 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669007723 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669007724 active site 204669007725 ATP binding site [chemical binding]; other site 204669007726 substrate binding site [chemical binding]; other site 204669007727 activation loop (A-loop); other site 204669007728 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669007729 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 204669007730 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 204669007731 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 204669007732 Beta-lactamase; Region: Beta-lactamase; pfam00144 204669007733 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 204669007734 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 204669007735 phosphopeptide binding site; other site 204669007736 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669007737 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 204669007738 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 204669007739 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 204669007740 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669007741 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 204669007742 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 204669007743 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 204669007744 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 204669007745 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 204669007746 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 204669007747 Cysteine-rich domain; Region: CCG; pfam02754 204669007748 Cysteine-rich domain; Region: CCG; pfam02754 204669007749 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 204669007750 FAD binding domain; Region: FAD_binding_4; pfam01565 204669007751 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 204669007752 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 204669007753 Bacterial sugar transferase; Region: Bac_transf; pfam02397 204669007754 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 204669007755 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 204669007756 putative ADP-binding pocket [chemical binding]; other site 204669007757 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 204669007758 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 204669007759 active site 204669007760 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 204669007761 putative ADP-binding pocket [chemical binding]; other site 204669007762 Chain length determinant protein; Region: Wzz; pfam02706 204669007763 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 204669007764 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 204669007765 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 204669007766 SLBB domain; Region: SLBB; pfam10531 204669007767 SLBB domain; Region: SLBB; pfam10531 204669007768 Predicted integral membrane protein [Function unknown]; Region: COG5617 204669007769 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 204669007770 A functionally uncharacterized subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in...; Region: GH20_chitobiase-like_1; cd06570 204669007771 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 204669007772 active site 204669007773 Rubrerythrin [Energy production and conversion]; Region: COG1592 204669007774 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 204669007775 binuclear metal center [ion binding]; other site 204669007776 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 204669007777 iron binding site [ion binding]; other site 204669007778 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 204669007779 active site 204669007780 dimerization interface [polypeptide binding]; other site 204669007781 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 204669007782 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 204669007783 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 204669007784 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 204669007785 Fumarase C-terminus; Region: Fumerase_C; pfam05683 204669007786 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 204669007787 anti sigma factor interaction site; other site 204669007788 regulatory phosphorylation site [posttranslational modification]; other site 204669007789 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 204669007790 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 204669007791 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 204669007792 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 204669007793 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 204669007794 active site 204669007795 PHP Thumb interface [polypeptide binding]; other site 204669007796 metal binding site [ion binding]; metal-binding site 204669007797 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 204669007798 generic binding surface I; other site 204669007799 generic binding surface II; other site 204669007800 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 204669007801 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 204669007802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669007803 Coenzyme A binding pocket [chemical binding]; other site 204669007804 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 204669007805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669007806 FeS/SAM binding site; other site 204669007807 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 204669007808 Uncharacterized conserved protein [Function unknown]; Region: COG1565 204669007809 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669007810 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 204669007811 FtsX-like permease family; Region: FtsX; pfam02687 204669007812 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669007813 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 204669007814 FtsX-like permease family; Region: FtsX; pfam02687 204669007815 Double zinc ribbon; Region: DZR; pfam12773 204669007816 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 204669007817 DinB family; Region: DinB; cl17821 204669007818 DinB superfamily; Region: DinB_2; pfam12867 204669007819 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 204669007820 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 204669007821 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 204669007822 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 204669007823 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 204669007824 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 204669007825 active site 204669007826 catalytic site [active] 204669007827 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 204669007828 4-alpha-glucanotransferase; Provisional; Region: PRK14508 204669007829 SurA N-terminal domain; Region: SurA_N_3; cl07813 204669007830 periplasmic folding chaperone; Provisional; Region: PRK10788 204669007831 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 204669007832 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 204669007833 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 204669007834 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669007835 FeS/SAM binding site; other site 204669007836 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 204669007837 active site clefts [active] 204669007838 zinc binding site [ion binding]; other site 204669007839 dimer interface [polypeptide binding]; other site 204669007840 SnoaL-like domain; Region: SnoaL_2; pfam12680 204669007841 Domain of unknown function (DUF336); Region: DUF336; pfam03928 204669007842 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821 204669007843 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 204669007844 dimer interface [polypeptide binding]; other site 204669007845 active site 204669007846 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 204669007847 substrate binding site [chemical binding]; other site 204669007848 catalytic residue [active] 204669007849 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 204669007850 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 204669007851 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 204669007852 TrkA-N domain; Region: TrkA_N; pfam02254 204669007853 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 204669007854 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 204669007855 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 204669007856 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 204669007857 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 204669007858 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 204669007859 active site 204669007860 dimer interface [polypeptide binding]; other site 204669007861 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 204669007862 phosphorylation site [posttranslational modification] 204669007863 dimer interface [polypeptide binding]; other site 204669007864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669007865 ATP binding site [chemical binding]; other site 204669007866 Mg2+ binding site [ion binding]; other site 204669007867 G-X-G motif; other site 204669007868 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669007869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669007870 active site 204669007871 phosphorylation site [posttranslational modification] 204669007872 intermolecular recognition site; other site 204669007873 dimerization interface [polypeptide binding]; other site 204669007874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669007875 Walker A motif; other site 204669007876 ATP binding site [chemical binding]; other site 204669007877 Walker B motif; other site 204669007878 arginine finger; other site 204669007879 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669007880 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 204669007881 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 204669007882 catalytic residues [active] 204669007883 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 204669007884 methionine sulfoxide reductase B; Provisional; Region: PRK00222 204669007885 SelR domain; Region: SelR; pfam01641 204669007886 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 204669007887 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669007888 Family of unknown function (DUF695); Region: DUF695; pfam05117 204669007889 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 204669007890 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 204669007891 putative active site [active] 204669007892 Zn binding site [ion binding]; other site 204669007893 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 204669007894 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 204669007895 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 204669007896 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 204669007897 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 204669007898 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_long; TIGR01348 204669007899 E3 interaction surface; other site 204669007900 lipoyl attachment site [posttranslational modification]; other site 204669007901 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 204669007902 E3 interaction surface; other site 204669007903 lipoyl attachment site [posttranslational modification]; other site 204669007904 e3 binding domain; Region: E3_binding; pfam02817 204669007905 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 204669007906 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 204669007907 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 204669007908 dimer interface [polypeptide binding]; other site 204669007909 TPP-binding site [chemical binding]; other site 204669007910 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 204669007911 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 204669007912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669007913 homodimer interface [polypeptide binding]; other site 204669007914 catalytic residue [active] 204669007915 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 204669007916 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 204669007917 FAD binding pocket [chemical binding]; other site 204669007918 FAD binding motif [chemical binding]; other site 204669007919 phosphate binding motif [ion binding]; other site 204669007920 beta-alpha-beta structure motif; other site 204669007921 NAD binding pocket [chemical binding]; other site 204669007922 Iron coordination center [ion binding]; other site 204669007923 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 204669007924 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 204669007925 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 204669007926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669007927 Walker A/P-loop; other site 204669007928 ATP binding site [chemical binding]; other site 204669007929 Q-loop/lid; other site 204669007930 ABC transporter signature motif; other site 204669007931 Walker B; other site 204669007932 D-loop; other site 204669007933 H-loop/switch region; other site 204669007934 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 204669007935 Ferredoxin [Energy production and conversion]; Region: COG1146 204669007936 4Fe-4S binding domain; Region: Fer4; cl02805 204669007937 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 204669007938 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 204669007939 phosphoserine phosphatase SerB; Region: serB; TIGR00338 204669007940 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 204669007941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 204669007942 motif II; other site 204669007943 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669007944 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669007945 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 204669007946 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669007947 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669007948 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 204669007949 Surface antigen; Region: Bac_surface_Ag; pfam01103 204669007950 Family of unknown function (DUF490); Region: DUF490; pfam04357 204669007951 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 204669007952 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 204669007953 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 204669007954 Domain interface; other site 204669007955 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 204669007956 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 204669007957 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 204669007958 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 204669007959 TPP-binding site [chemical binding]; other site 204669007960 dimer interface [polypeptide binding]; other site 204669007961 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 204669007962 PYR/PP interface [polypeptide binding]; other site 204669007963 dimer interface [polypeptide binding]; other site 204669007964 TPP binding site [chemical binding]; other site 204669007965 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 204669007966 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 204669007967 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 204669007968 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 204669007969 putative active site [active] 204669007970 catalytic residue [active] 204669007971 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 204669007972 SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798 204669007973 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 204669007974 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 204669007975 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 204669007976 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 204669007977 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 204669007978 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 204669007979 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 204669007980 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 204669007981 active site 204669007982 motif I; other site 204669007983 motif II; other site 204669007984 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 204669007985 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 204669007986 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 204669007987 putative active site [active] 204669007988 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 204669007989 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 204669007990 catalytic triad [active] 204669007991 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 204669007992 Protein export membrane protein; Region: SecD_SecF; cl14618 204669007993 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 204669007994 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 204669007995 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669007996 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 204669007997 PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121 204669007998 apical/protease domain interface [polypeptide binding]; other site 204669007999 substrate binding [chemical binding]; other site 204669008000 dimer interface [polypeptide binding]; other site 204669008001 M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022 204669008002 dimer interface [polypeptide binding]; other site 204669008003 Peptidase family M28; Region: Peptidase_M28; pfam04389 204669008004 active site 204669008005 metal binding site [ion binding]; metal-binding site 204669008006 Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253 204669008007 Predicted acyl esterases [General function prediction only]; Region: COG2936 204669008008 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669008009 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 204669008010 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 204669008011 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 204669008012 Walker A/P-loop; other site 204669008013 ATP binding site [chemical binding]; other site 204669008014 Q-loop/lid; other site 204669008015 ABC transporter signature motif; other site 204669008016 Walker B; other site 204669008017 D-loop; other site 204669008018 H-loop/switch region; other site 204669008019 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 204669008020 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 204669008021 PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121 204669008022 apical/protease domain interface [polypeptide binding]; other site 204669008023 substrate binding [chemical binding]; other site 204669008024 dimer interface [polypeptide binding]; other site 204669008025 M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022 204669008026 dimer interface [polypeptide binding]; other site 204669008027 Peptidase family M28; Region: Peptidase_M28; pfam04389 204669008028 active site 204669008029 metal binding site [ion binding]; metal-binding site 204669008030 Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253 204669008031 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 204669008032 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 204669008033 hypothetical protein; Provisional; Region: PRK07236 204669008034 Putative esterase; Region: Esterase; pfam00756 204669008035 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 204669008036 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 204669008037 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669008038 FtsX-like permease family; Region: FtsX; pfam02687 204669008039 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 204669008040 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 204669008041 Walker A/P-loop; other site 204669008042 ATP binding site [chemical binding]; other site 204669008043 Q-loop/lid; other site 204669008044 ABC transporter signature motif; other site 204669008045 Walker B; other site 204669008046 D-loop; other site 204669008047 H-loop/switch region; other site 204669008048 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 204669008049 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 204669008050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669008051 Walker A/P-loop; other site 204669008052 ATP binding site [chemical binding]; other site 204669008053 Q-loop/lid; other site 204669008054 ABC transporter signature motif; other site 204669008055 Walker B; other site 204669008056 D-loop; other site 204669008057 H-loop/switch region; other site 204669008058 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 204669008059 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 204669008060 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669008061 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 204669008062 Protein export membrane protein; Region: SecD_SecF; cl14618 204669008063 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 204669008064 Protein export membrane protein; Region: SecD_SecF; cl14618 204669008065 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 204669008066 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 204669008067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669008068 NAD(P) binding site [chemical binding]; other site 204669008069 active site 204669008070 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 204669008071 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 204669008072 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 204669008073 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 204669008074 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 204669008075 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 204669008076 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 204669008077 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 204669008078 substrate binding site; other site 204669008079 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 204669008080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669008081 NAD(P) binding site [chemical binding]; other site 204669008082 active site 204669008083 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 204669008084 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 204669008085 inhibitor-cofactor binding pocket; inhibition site 204669008086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669008087 catalytic residue [active] 204669008088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669008089 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 204669008090 NAD(P) binding site [chemical binding]; other site 204669008091 active site 204669008092 NeuB family; Region: NeuB; pfam03102 204669008093 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 204669008094 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 204669008095 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 204669008096 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 204669008097 PYR/PP interface [polypeptide binding]; other site 204669008098 dimer interface [polypeptide binding]; other site 204669008099 TPP binding site [chemical binding]; other site 204669008100 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 204669008101 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 204669008102 TPP-binding site [chemical binding]; other site 204669008103 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 204669008104 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 204669008105 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 204669008106 flagellin modification protein A; Provisional; Region: PRK09186 204669008107 classical (c) SDR, subgroup 8; Region: SDR_c8; cd08930 204669008108 putative NAD(P) binding site [chemical binding]; other site 204669008109 active site 204669008110 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 204669008111 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 204669008112 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 204669008113 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 204669008114 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 204669008115 Ligand binding site; other site 204669008116 Putative Catalytic site; other site 204669008117 DXD motif; other site 204669008118 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 204669008119 Peptidase family M48; Region: Peptidase_M48; cl12018 204669008120 Penicillinase repressor; Region: Pencillinase_R; cl17580 204669008121 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 204669008122 Amidase; Region: Amidase; cl11426 204669008123 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 204669008124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 204669008125 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 204669008126 SEC-C motif; Region: SEC-C; pfam02810 204669008127 hypothetical protein; Validated; Region: PRK06186 204669008128 conserved cys residue [active] 204669008129 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 204669008130 dimerization interface [polypeptide binding]; other site 204669008131 metal binding site [ion binding]; metal-binding site 204669008132 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 204669008133 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 204669008134 acyl-activating enzyme (AAE) consensus motif; other site 204669008135 putative AMP binding site [chemical binding]; other site 204669008136 putative active site [active] 204669008137 putative CoA binding site [chemical binding]; other site 204669008138 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 204669008139 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 204669008140 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 204669008141 putative acyl-acceptor binding pocket; other site 204669008142 PilZ domain; Region: PilZ; pfam07238 204669008143 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 204669008144 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 204669008145 active site 204669008146 DNA binding site [nucleotide binding] 204669008147 Int/Topo IB signature motif; other site 204669008148 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 204669008149 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 204669008150 active site 204669008151 DNA binding site [nucleotide binding] 204669008152 Int/Topo IB signature motif; other site 204669008153 Protein of unknown function DUF72; Region: DUF72; pfam01904 204669008154 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 204669008155 nucleotide binding site [chemical binding]; other site 204669008156 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 204669008157 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 204669008158 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 204669008159 active site 204669008160 metal binding site [ion binding]; metal-binding site 204669008161 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 204669008162 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 204669008163 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669008164 Zn2+ binding site [ion binding]; other site 204669008165 Mg2+ binding site [ion binding]; other site 204669008166 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 204669008167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 204669008168 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 204669008169 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 204669008170 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 204669008171 active site 204669008172 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 204669008173 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 204669008174 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 204669008175 G-X-X-G motif; other site 204669008176 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 204669008177 RimM N-terminal domain; Region: RimM; pfam01782 204669008178 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 204669008179 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 204669008180 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 204669008181 RNA/DNA hybrid binding site [nucleotide binding]; other site 204669008182 active site 204669008183 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 204669008184 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 204669008185 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669008186 FeS/SAM binding site; other site 204669008187 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 204669008188 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 204669008189 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 204669008190 Lumazine binding domain; Region: Lum_binding; pfam00677 204669008191 Lumazine binding domain; Region: Lum_binding; pfam00677 204669008192 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 204669008193 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 204669008194 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 204669008195 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 204669008196 Walker A/P-loop; other site 204669008197 ATP binding site [chemical binding]; other site 204669008198 Q-loop/lid; other site 204669008199 ABC transporter signature motif; other site 204669008200 Walker B; other site 204669008201 D-loop; other site 204669008202 H-loop/switch region; other site 204669008203 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 204669008204 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 204669008205 GTP binding site; other site 204669008206 Ion channel; Region: Ion_trans_2; pfam07885 204669008207 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 204669008208 TrkA-N domain; Region: TrkA_N; pfam02254 204669008209 TrkA-C domain; Region: TrkA_C; pfam02080 204669008210 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 204669008211 Permease; Region: Permease; pfam02405 204669008212 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 204669008213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669008214 Walker A/P-loop; other site 204669008215 ATP binding site [chemical binding]; other site 204669008216 Q-loop/lid; other site 204669008217 ABC transporter signature motif; other site 204669008218 Walker B; other site 204669008219 D-loop; other site 204669008220 H-loop/switch region; other site 204669008221 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669008222 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669008223 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 204669008224 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 204669008225 DEAD-like helicases superfamily; Region: DEXDc; smart00487 204669008226 ATP binding site [chemical binding]; other site 204669008227 Mg++ binding site [ion binding]; other site 204669008228 motif III; other site 204669008229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 204669008230 nucleotide binding region [chemical binding]; other site 204669008231 ATP-binding site [chemical binding]; other site 204669008232 Response regulator receiver domain; Region: Response_reg; pfam00072 204669008233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669008234 active site 204669008235 phosphorylation site [posttranslational modification] 204669008236 intermolecular recognition site; other site 204669008237 dimerization interface [polypeptide binding]; other site 204669008238 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669008239 GAF domain; Region: GAF; pfam01590 204669008240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669008241 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 204669008242 putative active site [active] 204669008243 heme pocket [chemical binding]; other site 204669008244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669008245 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 204669008246 putative active site [active] 204669008247 heme pocket [chemical binding]; other site 204669008248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669008249 dimer interface [polypeptide binding]; other site 204669008250 phosphorylation site [posttranslational modification] 204669008251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669008252 ATP binding site [chemical binding]; other site 204669008253 Mg2+ binding site [ion binding]; other site 204669008254 G-X-G motif; other site 204669008255 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669008256 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669008257 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669008258 FtsX-like permease family; Region: FtsX; pfam02687 204669008259 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669008260 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 204669008261 Predicted membrane protein [Function unknown]; Region: COG2259 204669008262 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669008263 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 204669008264 active site 204669008265 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 204669008266 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 204669008267 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669008268 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669008269 DNA binding residues [nucleotide binding] 204669008270 dimerization interface [polypeptide binding]; other site 204669008271 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 204669008272 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 204669008273 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 204669008274 DXD motif; other site 204669008275 metallophosphoesterase, RPA4764 family; Region: RPA4764; TIGR03768 204669008276 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 204669008277 Uncharacterized conserved protein [Function unknown]; Region: COG3391 204669008278 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 204669008279 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 204669008280 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 204669008281 Trehalose utilisation; Region: ThuA; pfam06283 204669008282 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 204669008283 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 204669008284 active site 204669008285 trimer interface [polypeptide binding]; other site 204669008286 allosteric site; other site 204669008287 active site lid [active] 204669008288 hexamer (dimer of trimers) interface [polypeptide binding]; other site 204669008289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669008290 D-galactonate transporter; Region: 2A0114; TIGR00893 204669008291 putative substrate translocation pore; other site 204669008292 TROVE domain; Region: TROVE; pfam05731 204669008293 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 204669008294 metal ion-dependent adhesion site (MIDAS); other site 204669008295 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 204669008296 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 204669008297 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 204669008298 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 204669008299 substrate binding site [chemical binding]; other site 204669008300 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 204669008301 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 204669008302 substrate binding site [chemical binding]; other site 204669008303 ligand binding site [chemical binding]; other site 204669008304 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 204669008305 tartrate dehydrogenase; Region: TTC; TIGR02089 204669008306 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 204669008307 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 204669008308 active site 204669008309 catalytic residues [active] 204669008310 metal binding site [ion binding]; metal-binding site 204669008311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 204669008312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 204669008313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 204669008314 dimerization interface [polypeptide binding]; other site 204669008315 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 204669008316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669008317 active site 204669008318 phosphorylation site [posttranslational modification] 204669008319 intermolecular recognition site; other site 204669008320 dimerization interface [polypeptide binding]; other site 204669008321 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 204669008322 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 204669008323 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 204669008324 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 204669008325 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 204669008326 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 204669008327 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 204669008328 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 204669008329 Flagellar L-ring protein; Region: FlgH; pfam02107 204669008330 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 204669008331 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 204669008332 Rod binding protein; Region: Rod-binding; cl01626 204669008333 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 204669008334 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 204669008335 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 204669008336 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 204669008337 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 204669008338 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 204669008339 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 204669008340 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 204669008341 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 204669008342 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 204669008343 ligand binding site [chemical binding]; other site 204669008344 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 204669008345 Flagellar protein (FlbD); Region: FlbD; pfam06289 204669008346 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 204669008347 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 204669008348 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 204669008349 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 204669008350 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 204669008351 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 204669008352 Flagellar protein FliS; Region: FliS; cl00654 204669008353 Response regulator receiver domain; Region: Response_reg; pfam00072 204669008354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669008355 active site 204669008356 phosphorylation site [posttranslational modification] 204669008357 intermolecular recognition site; other site 204669008358 dimerization interface [polypeptide binding]; other site 204669008359 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 204669008360 M28 Zn-Peptidases; Region: M28_like_4; cd08015 204669008361 Peptidase family M28; Region: Peptidase_M28; pfam04389 204669008362 metal binding site [ion binding]; metal-binding site 204669008363 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 204669008364 Ligand Binding Site [chemical binding]; other site 204669008365 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 204669008366 Ligand Binding Site [chemical binding]; other site 204669008367 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 204669008368 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 204669008369 NAD(P) binding pocket [chemical binding]; other site 204669008370 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 204669008371 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 204669008372 4Fe-4S binding domain; Region: Fer4_6; pfam12837 204669008373 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 204669008374 lipoyl attachment site [posttranslational modification]; other site 204669008375 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669008376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669008377 active site 204669008378 phosphorylation site [posttranslational modification] 204669008379 intermolecular recognition site; other site 204669008380 dimerization interface [polypeptide binding]; other site 204669008381 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 204669008382 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 204669008383 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 204669008384 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669008385 FeS/SAM binding site; other site 204669008386 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 204669008387 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 204669008388 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 204669008389 Cl- selectivity filter; other site 204669008390 Cl- binding residues [ion binding]; other site 204669008391 pore gating glutamate residue; other site 204669008392 dimer interface [polypeptide binding]; other site 204669008393 FOG: CBS domain [General function prediction only]; Region: COG0517 204669008394 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593 204669008395 MarR family; Region: MarR_2; pfam12802 204669008396 adenylosuccinate lyase; Provisional; Region: PRK07492 204669008397 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 204669008398 tetramer interface [polypeptide binding]; other site 204669008399 active site 204669008400 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 204669008401 Predicted membrane protein [Function unknown]; Region: COG2259 204669008402 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 204669008403 MarR family; Region: MarR; pfam01047 204669008404 MarR family; Region: MarR_2; cl17246 204669008405 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669008406 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 204669008407 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 204669008408 Low molecular weight phosphatase family; Region: LMWPc; cd00115 204669008409 active site 204669008410 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 204669008411 arsenical-resistance protein; Region: acr3; TIGR00832 204669008412 Methyltransferase domain; Region: Methyltransf_31; pfam13847 204669008413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669008414 S-adenosylmethionine binding site [chemical binding]; other site 204669008415 Transcriptional regulators [Transcription]; Region: MarR; COG1846 204669008416 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 204669008417 putative Zn2+ binding site [ion binding]; other site 204669008418 putative DNA binding site [nucleotide binding]; other site 204669008419 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 204669008420 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 204669008421 dimer interface [polypeptide binding]; other site 204669008422 active site 204669008423 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 204669008424 dimer interface [polypeptide binding]; other site 204669008425 active site 204669008426 citrate lyase, alpha subunit; Region: citF; TIGR01584 204669008427 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 204669008428 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 204669008429 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 204669008430 tartrate dehydrogenase; Region: TTC; TIGR02089 204669008431 homoaconitase; Region: h_aconitase; TIGR00139 204669008432 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 204669008433 substrate binding site [chemical binding]; other site 204669008434 ligand binding site [chemical binding]; other site 204669008435 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 204669008436 substrate binding site [chemical binding]; other site 204669008437 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 204669008438 2-methylcitrate dehydratase; Region: prpD; TIGR02330 204669008439 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 204669008440 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 204669008441 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 204669008442 acyl-activating enzyme (AAE) consensus motif; other site 204669008443 putative AMP binding site [chemical binding]; other site 204669008444 putative active site [active] 204669008445 putative CoA binding site [chemical binding]; other site 204669008446 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 204669008447 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 204669008448 putative acyl-acceptor binding pocket; other site 204669008449 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 204669008450 putative DNA binding site [nucleotide binding]; other site 204669008451 dimerization interface [polypeptide binding]; other site 204669008452 putative Zn2+ binding site [ion binding]; other site 204669008453 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 204669008454 PhoU domain; Region: PhoU; pfam01895 204669008455 PhoU domain; Region: PhoU; pfam01895 204669008456 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 204669008457 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 204669008458 Walker A/P-loop; other site 204669008459 ATP binding site [chemical binding]; other site 204669008460 Q-loop/lid; other site 204669008461 ABC transporter signature motif; other site 204669008462 Walker B; other site 204669008463 D-loop; other site 204669008464 H-loop/switch region; other site 204669008465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 204669008466 dimer interface [polypeptide binding]; other site 204669008467 conserved gate region; other site 204669008468 putative PBP binding loops; other site 204669008469 ABC-ATPase subunit interface; other site 204669008470 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 204669008471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 204669008472 dimer interface [polypeptide binding]; other site 204669008473 conserved gate region; other site 204669008474 putative PBP binding loops; other site 204669008475 ABC-ATPase subunit interface; other site 204669008476 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 204669008477 PhoU domain; Region: PhoU; pfam01895 204669008478 PhoU domain; Region: PhoU; pfam01895 204669008479 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 204669008480 Beta-lactamase; Region: Beta-lactamase; pfam00144 204669008481 Family description; Region: VCBS; pfam13517 204669008482 Family description; Region: VCBS; pfam13517 204669008483 Family description; Region: VCBS; pfam13517 204669008484 Family description; Region: VCBS; pfam13517 204669008485 Family description; Region: VCBS; pfam13517 204669008486 Family description; Region: VCBS; pfam13517 204669008487 Family description; Region: VCBS; pfam13517 204669008488 Family description; Region: VCBS; pfam13517 204669008489 Family description; Region: VCBS; pfam13517 204669008490 Family description; Region: VCBS; pfam13517 204669008491 Family description; Region: VCBS; pfam13517 204669008492 Family description; Region: VCBS; pfam13517 204669008493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 204669008494 DNA-binding site [nucleotide binding]; DNA binding site 204669008495 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 204669008496 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 204669008497 Walker A/P-loop; other site 204669008498 ATP binding site [chemical binding]; other site 204669008499 Q-loop/lid; other site 204669008500 ABC transporter signature motif; other site 204669008501 Walker B; other site 204669008502 D-loop; other site 204669008503 H-loop/switch region; other site 204669008504 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669008505 GAF domain; Region: GAF; pfam01590 204669008506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 204669008507 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 204669008508 ATP binding site [chemical binding]; other site 204669008509 Mg2+ binding site [ion binding]; other site 204669008510 G-X-G motif; other site 204669008511 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 204669008512 amphipathic channel; other site 204669008513 Asn-Pro-Ala signature motifs; other site 204669008514 glycerol kinase; Provisional; Region: glpK; PRK00047 204669008515 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 204669008516 N- and C-terminal domain interface [polypeptide binding]; other site 204669008517 active site 204669008518 MgATP binding site [chemical binding]; other site 204669008519 catalytic site [active] 204669008520 metal binding site [ion binding]; metal-binding site 204669008521 glycerol binding site [chemical binding]; other site 204669008522 homotetramer interface [polypeptide binding]; other site 204669008523 homodimer interface [polypeptide binding]; other site 204669008524 FBP binding site [chemical binding]; other site 204669008525 protein IIAGlc interface [polypeptide binding]; other site 204669008526 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 204669008527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669008528 dimerization interface [polypeptide binding]; other site 204669008529 PAS domain; Region: PAS; smart00091 204669008530 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 204669008531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669008532 dimer interface [polypeptide binding]; other site 204669008533 phosphorylation site [posttranslational modification] 204669008534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669008535 ATP binding site [chemical binding]; other site 204669008536 Mg2+ binding site [ion binding]; other site 204669008537 G-X-G motif; other site 204669008538 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669008539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669008540 active site 204669008541 phosphorylation site [posttranslational modification] 204669008542 intermolecular recognition site; other site 204669008543 dimerization interface [polypeptide binding]; other site 204669008544 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669008545 DNA binding site [nucleotide binding] 204669008546 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 204669008547 FAD binding domain; Region: FAD_binding_4; pfam01565 204669008548 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 204669008549 Cysteine-rich domain; Region: CCG; pfam02754 204669008550 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 204669008551 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 204669008552 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 204669008553 Subunit I/III interface [polypeptide binding]; other site 204669008554 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 204669008555 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 204669008556 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 204669008557 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 204669008558 Cytochrome c; Region: Cytochrom_C; pfam00034 204669008559 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 204669008560 Cu(I) binding site [ion binding]; other site 204669008561 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669008562 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 204669008563 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 204669008564 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 204669008565 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 204669008566 molybdopterin cofactor binding site; other site 204669008567 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 204669008568 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 204669008569 4Fe-4S binding domain; Region: Fer4_2; pfam12797 204669008570 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 204669008571 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 204669008572 heme-binding residues [chemical binding]; other site 204669008573 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 204669008574 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 204669008575 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 204669008576 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669008577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669008578 TPR motif; other site 204669008579 TPR repeat; Region: TPR_11; pfam13414 204669008580 binding surface 204669008581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669008582 binding surface 204669008583 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669008584 TPR motif; other site 204669008585 TPR repeat; Region: TPR_11; pfam13414 204669008586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669008587 binding surface 204669008588 TPR motif; other site 204669008589 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 204669008590 CoA binding domain; Region: CoA_binding_2; pfam13380 204669008591 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 204669008592 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 204669008593 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 204669008594 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 204669008595 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 204669008596 active site 204669008597 metal binding site [ion binding]; metal-binding site 204669008598 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 204669008599 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669008600 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 204669008601 metal ion-dependent adhesion site (MIDAS); other site 204669008602 Predicted integral membrane protein [Function unknown]; Region: COG5637 204669008603 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 204669008604 putative hydrophobic ligand binding site [chemical binding]; other site 204669008605 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 204669008606 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 204669008607 NAD binding site [chemical binding]; other site 204669008608 catalytic Zn binding site [ion binding]; other site 204669008609 structural Zn binding site [ion binding]; other site 204669008610 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 204669008611 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 204669008612 dimerization interface [polypeptide binding]; other site 204669008613 putative ATP binding site [chemical binding]; other site 204669008614 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 204669008615 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 204669008616 active site 204669008617 substrate binding site [chemical binding]; other site 204669008618 cosubstrate binding site; other site 204669008619 catalytic site [active] 204669008620 Inward rectifier potassium channel; Region: IRK; pfam01007 204669008621 PAS domain S-box; Region: sensory_box; TIGR00229 204669008622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669008623 putative active site [active] 204669008624 heme pocket [chemical binding]; other site 204669008625 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669008626 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 204669008627 PAS domain S-box; Region: sensory_box; TIGR00229 204669008628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669008629 putative active site [active] 204669008630 heme pocket [chemical binding]; other site 204669008631 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669008632 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 204669008633 PAS domain S-box; Region: sensory_box; TIGR00229 204669008634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669008635 putative active site [active] 204669008636 heme pocket [chemical binding]; other site 204669008637 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669008638 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669008639 dimer interface [polypeptide binding]; other site 204669008640 phosphorylation site [posttranslational modification] 204669008641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669008642 ATP binding site [chemical binding]; other site 204669008643 Mg2+ binding site [ion binding]; other site 204669008644 G-X-G motif; other site 204669008645 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669008646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669008647 active site 204669008648 phosphorylation site [posttranslational modification] 204669008649 intermolecular recognition site; other site 204669008650 dimerization interface [polypeptide binding]; other site 204669008651 4Fe-4S binding domain; Region: Fer4_5; pfam12801 204669008652 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 204669008653 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 204669008654 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 204669008655 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 204669008656 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669008657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669008658 active site 204669008659 phosphorylation site [posttranslational modification] 204669008660 intermolecular recognition site; other site 204669008661 dimerization interface [polypeptide binding]; other site 204669008662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669008663 Walker A motif; other site 204669008664 ATP binding site [chemical binding]; other site 204669008665 Walker B motif; other site 204669008666 arginine finger; other site 204669008667 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669008668 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 204669008669 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669008670 putative active site [active] 204669008671 heme pocket [chemical binding]; other site 204669008672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669008673 dimer interface [polypeptide binding]; other site 204669008674 phosphorylation site [posttranslational modification] 204669008675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669008676 ATP binding site [chemical binding]; other site 204669008677 Mg2+ binding site [ion binding]; other site 204669008678 G-X-G motif; other site 204669008679 Response regulator receiver domain; Region: Response_reg; pfam00072 204669008680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669008681 active site 204669008682 phosphorylation site [posttranslational modification] 204669008683 intermolecular recognition site; other site 204669008684 dimerization interface [polypeptide binding]; other site 204669008685 PilZ domain; Region: PilZ; pfam07238 204669008686 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 204669008687 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 204669008688 VPS10 domain; Region: VPS10; smart00602 204669008689 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 204669008690 VPS10 domain; Region: VPS10; smart00602 204669008691 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 204669008692 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669008693 dimer interface [polypeptide binding]; other site 204669008694 substrate binding site [chemical binding]; other site 204669008695 metal binding site [ion binding]; metal-binding site 204669008696 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 204669008697 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 204669008698 carboxyltransferase (CT) interaction site; other site 204669008699 biotinylation site [posttranslational modification]; other site 204669008700 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 204669008701 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 204669008702 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 204669008703 oxaloacetate decarboxylase; Provisional; Region: PRK12330 204669008704 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 204669008705 active site 204669008706 catalytic residues [active] 204669008707 metal binding site [ion binding]; metal-binding site 204669008708 homodimer binding site [polypeptide binding]; other site 204669008709 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 204669008710 active site 204669008711 HIGH motif; other site 204669008712 nucleotide binding site [chemical binding]; other site 204669008713 active site 204669008714 KMSKS motif; other site 204669008715 FeoA domain; Region: FeoA; pfam04023 204669008716 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 204669008717 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 204669008718 G1 box; other site 204669008719 GTP/Mg2+ binding site [chemical binding]; other site 204669008720 Switch I region; other site 204669008721 G2 box; other site 204669008722 G3 box; other site 204669008723 Switch II region; other site 204669008724 G4 box; other site 204669008725 G5 box; other site 204669008726 Nucleoside recognition; Region: Gate; pfam07670 204669008727 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 204669008728 Nucleoside recognition; Region: Gate; pfam07670 204669008729 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 204669008730 putative aminotransferase; Provisional; Region: PRK09105 204669008731 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 204669008732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669008733 homodimer interface [polypeptide binding]; other site 204669008734 catalytic residue [active] 204669008735 6-phosphofructokinase; Provisional; Region: PRK03202 204669008736 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 204669008737 active site 204669008738 ADP/pyrophosphate binding site [chemical binding]; other site 204669008739 dimerization interface [polypeptide binding]; other site 204669008740 allosteric effector site; other site 204669008741 fructose-1,6-bisphosphate binding site; other site 204669008742 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 204669008743 BON domain; Region: BON; pfam04972 204669008744 BON domain; Region: BON; cl02771 204669008745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669008746 Major Facilitator Superfamily; Region: MFS_1; pfam07690 204669008747 putative substrate translocation pore; other site 204669008748 signal recognition particle protein; Provisional; Region: PRK10867 204669008749 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 204669008750 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 204669008751 P loop; other site 204669008752 GTP binding site [chemical binding]; other site 204669008753 Signal peptide binding domain; Region: SRP_SPB; pfam02978 204669008754 Amino acid permease; Region: AA_permease_2; pfam13520 204669008755 hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367 204669008756 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 204669008757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669008758 FeS/SAM binding site; other site 204669008759 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 204669008760 D-glutamate deacylase; Validated; Region: PRK09061 204669008761 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 204669008762 active site 204669008763 putative substrate binding pocket [chemical binding]; other site 204669008764 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669008765 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669008766 FtsX-like permease family; Region: FtsX; pfam02687 204669008767 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669008768 FtsX-like permease family; Region: FtsX; pfam02687 204669008769 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 204669008770 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 204669008771 Acyltransferase family; Region: Acyl_transf_3; pfam01757 204669008772 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 204669008773 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 204669008774 putative NAD(P) binding site [chemical binding]; other site 204669008775 putative substrate binding site [chemical binding]; other site 204669008776 catalytic Zn binding site [ion binding]; other site 204669008777 structural Zn binding site [ion binding]; other site 204669008778 Cytochrome P450; Region: p450; pfam00067 204669008779 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 204669008780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669008781 sequence-specific DNA binding site [nucleotide binding]; other site 204669008782 salt bridge; other site 204669008783 Cupin domain; Region: Cupin_2; pfam07883 204669008784 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 204669008785 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 204669008786 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 204669008787 Cu(I) binding site [ion binding]; other site 204669008788 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 204669008789 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 204669008790 cyclase homology domain; Region: CHD; cd07302 204669008791 nucleotidyl binding site; other site 204669008792 metal binding site [ion binding]; metal-binding site 204669008793 dimer interface [polypeptide binding]; other site 204669008794 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 204669008795 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 204669008796 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 204669008797 active site residue [active] 204669008798 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 204669008799 homodimer interface [polypeptide binding]; other site 204669008800 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 204669008801 active site pocket [active] 204669008802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669008803 TPR motif; other site 204669008804 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669008805 binding surface 204669008806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 204669008807 Uncharacterized conserved protein [Function unknown]; Region: COG3391 204669008808 Phosphoesterase family; Region: Phosphoesterase; pfam04185 204669008809 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 204669008810 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 204669008811 active site 204669008812 purine nucleoside phosphorylase; Provisional; Region: PRK08202 204669008813 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 204669008814 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 204669008815 Nucleoside recognition; Region: Gate; pfam07670 204669008816 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 204669008817 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 204669008818 intersubunit interface [polypeptide binding]; other site 204669008819 active site 204669008820 catalytic residue [active] 204669008821 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 204669008822 active site 204669008823 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669008824 active site 204669008825 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669008826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669008827 active site 204669008828 phosphorylation site [posttranslational modification] 204669008829 intermolecular recognition site; other site 204669008830 dimerization interface [polypeptide binding]; other site 204669008831 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669008832 DNA binding site [nucleotide binding] 204669008833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669008834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669008835 dimer interface [polypeptide binding]; other site 204669008836 phosphorylation site [posttranslational modification] 204669008837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669008838 ATP binding site [chemical binding]; other site 204669008839 Mg2+ binding site [ion binding]; other site 204669008840 G-X-G motif; other site 204669008841 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 204669008842 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 204669008843 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 204669008844 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 204669008845 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 204669008846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669008847 Walker A/P-loop; other site 204669008848 ATP binding site [chemical binding]; other site 204669008849 Q-loop/lid; other site 204669008850 ABC transporter signature motif; other site 204669008851 Walker B; other site 204669008852 D-loop; other site 204669008853 H-loop/switch region; other site 204669008854 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 204669008855 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 204669008856 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 204669008857 Ferredoxin [Energy production and conversion]; Region: COG1146 204669008858 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669008859 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669008860 Amidohydrolase; Region: Amidohydro_4; pfam13147 204669008861 active site 204669008862 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 204669008863 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 204669008864 catalytic residues [active] 204669008865 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669008866 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 204669008867 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 204669008868 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 204669008869 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 204669008870 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 204669008871 active site 204669008872 HIGH motif; other site 204669008873 dimer interface [polypeptide binding]; other site 204669008874 KMSKS motif; other site 204669008875 S4 domain; Region: S4; pfam01479 204669008876 RNA binding surface [nucleotide binding]; other site 204669008877 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 204669008878 putative metal binding site [ion binding]; other site 204669008879 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669008880 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669008881 YCII-related domain; Region: YCII; cl00999 204669008882 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 204669008883 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 204669008884 putative NAD(P) binding site [chemical binding]; other site 204669008885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 204669008886 Transposase; Region: DEDD_Tnp_IS110; pfam01548 204669008887 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 204669008888 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 204669008889 Transposase; Region: DEDD_Tnp_IS110; pfam01548 204669008890 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 204669008891 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 204669008892 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 204669008893 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 204669008894 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 204669008895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669008896 Walker A/P-loop; other site 204669008897 ATP binding site [chemical binding]; other site 204669008898 Q-loop/lid; other site 204669008899 ABC transporter signature motif; other site 204669008900 Walker B; other site 204669008901 D-loop; other site 204669008902 H-loop/switch region; other site 204669008903 OsmC-like protein; Region: OsmC; pfam02566 204669008904 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 204669008905 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669008906 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669008907 DNA binding residues [nucleotide binding] 204669008908 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 204669008909 active site residue [active] 204669008910 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 204669008911 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 204669008912 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 204669008913 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669008914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669008915 PAS fold; Region: PAS_3; pfam08447 204669008916 putative active site [active] 204669008917 heme pocket [chemical binding]; other site 204669008918 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 204669008919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669008920 ATP binding site [chemical binding]; other site 204669008921 Mg2+ binding site [ion binding]; other site 204669008922 G-X-G motif; other site 204669008923 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669008924 Catalytic domain of Protein Kinases; Region: PKc; cd00180 204669008925 active site 204669008926 ATP binding site [chemical binding]; other site 204669008927 substrate binding site [chemical binding]; other site 204669008928 activation loop (A-loop); other site 204669008929 TPR repeat; Region: TPR_11; pfam13414 204669008930 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669008931 TPR motif; other site 204669008932 binding surface 204669008933 TPR repeat; Region: TPR_11; pfam13414 204669008934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669008935 binding surface 204669008936 TPR motif; other site 204669008937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 204669008938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 204669008939 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 204669008940 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 204669008941 putative NAD(P) binding site [chemical binding]; other site 204669008942 PilZ domain; Region: PilZ; pfam07238 204669008943 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 204669008944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669008945 putative substrate translocation pore; other site 204669008946 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 204669008947 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 204669008948 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669008949 Outer membrane efflux protein; Region: OEP; pfam02321 204669008950 Outer membrane efflux protein; Region: OEP; pfam02321 204669008951 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 204669008952 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 204669008953 NAD binding site [chemical binding]; other site 204669008954 substrate binding site [chemical binding]; other site 204669008955 homodimer interface [polypeptide binding]; other site 204669008956 active site 204669008957 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 204669008958 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 204669008959 inhibitor-cofactor binding pocket; inhibition site 204669008960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669008961 catalytic residue [active] 204669008962 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669008963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669008964 active site 204669008965 phosphorylation site [posttranslational modification] 204669008966 intermolecular recognition site; other site 204669008967 dimerization interface [polypeptide binding]; other site 204669008968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669008969 DNA binding site [nucleotide binding] 204669008970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669008971 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669008972 dimerization interface [polypeptide binding]; other site 204669008973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669008974 dimer interface [polypeptide binding]; other site 204669008975 phosphorylation site [posttranslational modification] 204669008976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669008977 ATP binding site [chemical binding]; other site 204669008978 Mg2+ binding site [ion binding]; other site 204669008979 G-X-G motif; other site 204669008980 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 204669008981 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 204669008982 YceI-like domain; Region: YceI; pfam04264 204669008983 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 204669008984 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 204669008985 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 204669008986 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 204669008987 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 204669008988 malonyl-CoA binding site [chemical binding]; other site 204669008989 dimer interface [polypeptide binding]; other site 204669008990 active site 204669008991 product binding site; other site 204669008992 ketol-acid reductoisomerase; Provisional; Region: PRK05479 204669008993 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 204669008994 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 204669008995 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 204669008996 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 204669008997 putative valine binding site [chemical binding]; other site 204669008998 dimer interface [polypeptide binding]; other site 204669008999 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 204669009000 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 204669009001 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 204669009002 PYR/PP interface [polypeptide binding]; other site 204669009003 dimer interface [polypeptide binding]; other site 204669009004 TPP binding site [chemical binding]; other site 204669009005 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 204669009006 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 204669009007 TPP-binding site [chemical binding]; other site 204669009008 dimer interface [polypeptide binding]; other site 204669009009 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 204669009010 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 204669009011 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 204669009012 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 204669009013 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 204669009014 catalytic loop [active] 204669009015 iron binding site [ion binding]; other site 204669009016 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 204669009017 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 204669009018 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 204669009019 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 204669009020 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 204669009021 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 204669009022 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 204669009023 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 204669009024 Amino acid permease; Region: AA_permease_2; pfam13520 204669009025 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669009026 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669009027 active site 204669009028 ATP binding site [chemical binding]; other site 204669009029 substrate binding site [chemical binding]; other site 204669009030 activation loop (A-loop); other site 204669009031 Predicted integral membrane protein [Function unknown]; Region: COG5616 204669009032 TPR repeat; Region: TPR_11; pfam13414 204669009033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669009034 TPR motif; other site 204669009035 binding surface 204669009036 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669009037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669009038 TPR motif; other site 204669009039 binding surface 204669009040 TPR repeat; Region: TPR_11; pfam13414 204669009041 TPR repeat; Region: TPR_11; pfam13414 204669009042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669009043 binding surface 204669009044 TPR motif; other site 204669009045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669009046 binding surface 204669009047 TPR repeat; Region: TPR_11; pfam13414 204669009048 TPR motif; other site 204669009049 TPR repeat; Region: TPR_11; pfam13414 204669009050 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14669 204669009051 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 204669009052 GIY-YIG motif/motif A; other site 204669009053 active site 204669009054 catalytic site [active] 204669009055 putative DNA binding site [nucleotide binding]; other site 204669009056 metal binding site [ion binding]; metal-binding site 204669009057 UvrB/uvrC motif; Region: UVR; pfam02151 204669009058 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 204669009059 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 204669009060 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 204669009061 ligand binding site [chemical binding]; other site 204669009062 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 204669009063 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 204669009064 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 204669009065 active site 204669009066 catalytic site [active] 204669009067 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 204669009068 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 204669009069 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 204669009070 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 204669009071 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 204669009072 dimerization interface [polypeptide binding]; other site 204669009073 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 204669009074 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 204669009075 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 204669009076 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 204669009077 NAD(P) binding site [chemical binding]; other site 204669009078 homodimer interface [polypeptide binding]; other site 204669009079 substrate binding site [chemical binding]; other site 204669009080 active site 204669009081 Methyltransferase domain; Region: Methyltransf_23; pfam13489 204669009082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669009083 S-adenosylmethionine binding site [chemical binding]; other site 204669009084 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 204669009085 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 204669009086 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 204669009087 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669009088 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669009089 DNA binding residues [nucleotide binding] 204669009090 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669009091 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 204669009092 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 204669009093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669009094 FeS/SAM binding site; other site 204669009095 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14839 204669009096 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 204669009097 catalytic residue [active] 204669009098 putative FPP diphosphate binding site; other site 204669009099 putative FPP binding hydrophobic cleft; other site 204669009100 dimer interface [polypeptide binding]; other site 204669009101 putative IPP diphosphate binding site; other site 204669009102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 204669009103 dimerization interface [polypeptide binding]; other site 204669009104 putative DNA binding site [nucleotide binding]; other site 204669009105 Transcriptional regulators [Transcription]; Region: MarR; COG1846 204669009106 putative Zn2+ binding site [ion binding]; other site 204669009107 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 204669009108 active site clefts [active] 204669009109 zinc binding site [ion binding]; other site 204669009110 dimer interface [polypeptide binding]; other site 204669009111 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 204669009112 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 204669009113 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 204669009114 dimerization interface [polypeptide binding]; other site 204669009115 active site 204669009116 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 204669009117 peptidase domain interface [polypeptide binding]; other site 204669009118 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 204669009119 active site 204669009120 catalytic triad [active] 204669009121 calcium binding site [ion binding]; other site 204669009122 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 204669009123 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 204669009124 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 204669009125 PilZ domain; Region: PilZ; pfam07238 204669009126 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 204669009127 Beta-lactamase; Region: Beta-lactamase; pfam00144 204669009128 PilZ domain; Region: PilZ; pfam07238 204669009129 PilZ domain; Region: PilZ; pfam07238 204669009130 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 204669009131 DNA binding site [nucleotide binding] 204669009132 Int/Topo IB signature motif; other site 204669009133 active site 204669009134 catalytic residues [active] 204669009135 DNA recombination protein RmuC; Provisional; Region: PRK10361 204669009136 Phage-related protein, tail component [Function unknown]; Region: COG4733 204669009137 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 204669009138 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 204669009139 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 204669009140 tandem repeat interface [polypeptide binding]; other site 204669009141 oligomer interface [polypeptide binding]; other site 204669009142 active site residues [active] 204669009143 Phage capsid family; Region: Phage_capsid; pfam05065 204669009144 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 204669009145 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 204669009146 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 204669009147 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 204669009148 MarR family; Region: MarR_2; cl17246 204669009149 Helix-turn-helix domain; Region: HTH_36; pfam13730 204669009150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 204669009151 Coenzyme A binding pocket [chemical binding]; other site 204669009152 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669009153 ParB-like nuclease domain; Region: ParB; smart00470 204669009154 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 204669009155 ZIP Zinc transporter; Region: Zip; pfam02535 204669009156 GTP-binding protein YchF; Reviewed; Region: PRK09601 204669009157 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 204669009158 G1 box; other site 204669009159 GTP/Mg2+ binding site [chemical binding]; other site 204669009160 G2 box; other site 204669009161 Switch I region; other site 204669009162 G3 box; other site 204669009163 Switch II region; other site 204669009164 G4 box; other site 204669009165 G5 box; other site 204669009166 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 204669009167 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 204669009168 MoxR-like ATPases [General function prediction only]; Region: COG0714 204669009169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669009170 Walker A motif; other site 204669009171 ATP binding site [chemical binding]; other site 204669009172 Walker B motif; other site 204669009173 arginine finger; other site 204669009174 Peptidase family M48; Region: Peptidase_M48; cl12018 204669009175 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 204669009176 Cytochrome C biogenesis protein; Region: CcmH; cl01179 204669009177 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 204669009178 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669009179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669009180 active site 204669009181 phosphorylation site [posttranslational modification] 204669009182 dimerization interface [polypeptide binding]; other site 204669009183 Response regulator receiver domain; Region: Response_reg; pfam00072 204669009184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669009185 active site 204669009186 phosphorylation site [posttranslational modification] 204669009187 intermolecular recognition site; other site 204669009188 dimerization interface [polypeptide binding]; other site 204669009189 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 204669009190 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669009191 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 204669009192 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669009193 active site 204669009194 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 204669009195 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 204669009196 adenylate kinase; Reviewed; Region: adk; PRK00279 204669009197 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 204669009198 AMP-binding site [chemical binding]; other site 204669009199 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 204669009200 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669009201 Peptidase family M48; Region: Peptidase_M48; cl12018 204669009202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669009203 S-adenosylmethionine binding site [chemical binding]; other site 204669009204 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669009205 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669009206 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669009207 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 204669009208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669009209 ATP binding site [chemical binding]; other site 204669009210 Mg2+ binding site [ion binding]; other site 204669009211 G-X-G motif; other site 204669009212 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 204669009213 ATP binding site [chemical binding]; other site 204669009214 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 204669009215 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 204669009216 cytidylate kinase; Provisional; Region: cmk; PRK00023 204669009217 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 204669009218 CMP-binding site; other site 204669009219 The sites determining sugar specificity; other site 204669009220 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 204669009221 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669009222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669009223 binding surface 204669009224 TPR motif; other site 204669009225 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 204669009226 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 204669009227 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 204669009228 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 204669009229 proline aminopeptidase P II; Provisional; Region: PRK10879 204669009230 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 204669009231 active site 204669009232 CAAX protease self-immunity; Region: Abi; pfam02517 204669009233 thymidylate kinase; Validated; Region: tmk; PRK00698 204669009234 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 204669009235 TMP-binding site; other site 204669009236 ATP-binding site [chemical binding]; other site 204669009237 transcription termination factor Rho; Provisional; Region: rho; PRK09376 204669009238 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 204669009239 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 204669009240 RNA binding site [nucleotide binding]; other site 204669009241 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 204669009242 multimer interface [polypeptide binding]; other site 204669009243 Walker A motif; other site 204669009244 ATP binding site [chemical binding]; other site 204669009245 Walker B motif; other site 204669009246 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 204669009247 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 204669009248 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 204669009249 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 204669009250 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 204669009251 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 204669009252 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 204669009253 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 204669009254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669009255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 204669009256 Walker A motif; other site 204669009257 ATP binding site [chemical binding]; other site 204669009258 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 204669009259 PilZ domain; Region: PilZ; pfam07238 204669009260 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 204669009261 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669009262 GAF domain; Region: GAF; pfam01590 204669009263 PAS domain; Region: PAS_9; pfam13426 204669009264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669009265 putative active site [active] 204669009266 heme pocket [chemical binding]; other site 204669009267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669009268 dimer interface [polypeptide binding]; other site 204669009269 phosphorylation site [posttranslational modification] 204669009270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669009271 ATP binding site [chemical binding]; other site 204669009272 Mg2+ binding site [ion binding]; other site 204669009273 G-X-G motif; other site 204669009274 Response regulator receiver domain; Region: Response_reg; pfam00072 204669009275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669009276 active site 204669009277 phosphorylation site [posttranslational modification] 204669009278 intermolecular recognition site; other site 204669009279 dimerization interface [polypeptide binding]; other site 204669009280 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 204669009281 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 204669009282 putative acyltransferase; Provisional; Region: PRK05790 204669009283 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 204669009284 dimer interface [polypeptide binding]; other site 204669009285 active site 204669009286 CAAX protease self-immunity; Region: Abi; pfam02517 204669009287 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 204669009288 RNA methyltransferase, RsmE family; Region: TIGR00046 204669009289 chaperone protein DnaJ; Provisional; Region: PRK10767 204669009290 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 204669009291 HSP70 interaction site [polypeptide binding]; other site 204669009292 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 204669009293 Zn binding sites [ion binding]; other site 204669009294 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 204669009295 dimer interface [polypeptide binding]; other site 204669009296 GrpE; Region: GrpE; pfam01025 204669009297 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 204669009298 dimer interface [polypeptide binding]; other site 204669009299 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 204669009300 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 204669009301 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 204669009302 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 204669009303 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 204669009304 Putative esterase; Region: Esterase; pfam00756 204669009305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 204669009306 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 204669009307 PA14 domain; Region: PA14; cl08459 204669009308 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 204669009309 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 204669009310 Beta-lactamase; Region: Beta-lactamase; pfam00144 204669009311 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 204669009312 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 204669009313 alpha-galactosidase; Region: PLN02808; cl17638 204669009314 Protein of unkown function (DUF1881); Region: DUF1881; pfam08964 204669009315 Beta/Gamma crystallin; Region: Crystall; cl02528 204669009316 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 204669009317 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 204669009318 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 204669009319 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 204669009320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669009321 TPR motif; other site 204669009322 TPR repeat; Region: TPR_11; pfam13414 204669009323 binding surface 204669009324 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 204669009325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669009326 NAD(P) binding site [chemical binding]; other site 204669009327 active site 204669009328 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 204669009329 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 204669009330 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 204669009331 metal ion-dependent adhesion site (MIDAS); other site 204669009332 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 204669009333 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 204669009334 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 204669009335 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 204669009336 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 204669009337 putative ADP-binding pocket [chemical binding]; other site 204669009338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 204669009339 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 204669009340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 204669009341 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 204669009342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 204669009343 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 204669009344 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 204669009345 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 204669009346 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 204669009347 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 204669009348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669009349 NAD(P) binding site [chemical binding]; other site 204669009350 active site 204669009351 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 204669009352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669009353 S-adenosylmethionine binding site [chemical binding]; other site 204669009354 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669009355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669009356 active site 204669009357 phosphorylation site [posttranslational modification] 204669009358 intermolecular recognition site; other site 204669009359 dimerization interface [polypeptide binding]; other site 204669009360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669009361 Walker A motif; other site 204669009362 ATP binding site [chemical binding]; other site 204669009363 Walker B motif; other site 204669009364 arginine finger; other site 204669009365 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669009366 BNR repeat-like domain; Region: BNR_2; pfam13088 204669009367 Bacterial Ig-like domain 2; Region: BID_2; smart00635 204669009368 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 204669009369 ligand binding site [chemical binding]; other site 204669009370 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669009371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669009372 active site 204669009373 phosphorylation site [posttranslational modification] 204669009374 intermolecular recognition site; other site 204669009375 dimerization interface [polypeptide binding]; other site 204669009376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669009377 Walker A motif; other site 204669009378 ATP binding site [chemical binding]; other site 204669009379 Walker B motif; other site 204669009380 arginine finger; other site 204669009381 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669009382 PAS domain; Region: PAS; smart00091 204669009383 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669009384 putative active site [active] 204669009385 heme pocket [chemical binding]; other site 204669009386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669009387 dimer interface [polypeptide binding]; other site 204669009388 phosphorylation site [posttranslational modification] 204669009389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669009390 ATP binding site [chemical binding]; other site 204669009391 Mg2+ binding site [ion binding]; other site 204669009392 G-X-G motif; other site 204669009393 Methyltransferase domain; Region: Methyltransf_24; pfam13578 204669009394 S-adenosylmethionine binding site [chemical binding]; other site 204669009395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669009396 H+ Antiporter protein; Region: 2A0121; TIGR00900 204669009397 putative substrate translocation pore; other site 204669009398 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 204669009399 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 204669009400 NAD binding site [chemical binding]; other site 204669009401 homotetramer interface [polypeptide binding]; other site 204669009402 homodimer interface [polypeptide binding]; other site 204669009403 substrate binding site [chemical binding]; other site 204669009404 active site 204669009405 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 204669009406 Uncharacterized conserved protein [Function unknown]; Region: COG0062 204669009407 putative carbohydrate kinase; Provisional; Region: PRK10565 204669009408 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 204669009409 putative substrate binding site [chemical binding]; other site 204669009410 putative ATP binding site [chemical binding]; other site 204669009411 Ion channel; Region: Ion_trans_2; pfam07885 204669009412 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 204669009413 TrkA-N domain; Region: TrkA_N; pfam02254 204669009414 TrkA-C domain; Region: TrkA_C; pfam02080 204669009415 amino acid transporter; Region: 2A0306; TIGR00909 204669009416 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 204669009417 amino acid transporter; Region: 2A0306; TIGR00909 204669009418 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 204669009419 thiamine phosphate binding site [chemical binding]; other site 204669009420 active site 204669009421 pyrophosphate binding site [ion binding]; other site 204669009422 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 204669009423 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 204669009424 ATP-grasp domain; Region: ATP-grasp_4; cl17255 204669009425 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 204669009426 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 204669009427 carboxyltransferase (CT) interaction site; other site 204669009428 biotinylation site [posttranslational modification]; other site 204669009429 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 204669009430 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 204669009431 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 204669009432 active site 204669009433 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 204669009434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669009435 active site 204669009436 phosphorylation site [posttranslational modification] 204669009437 intermolecular recognition site; other site 204669009438 dimerization interface [polypeptide binding]; other site 204669009439 LytTr DNA-binding domain; Region: LytTR; smart00850 204669009440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 204669009441 Histidine kinase; Region: His_kinase; pfam06580 204669009442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669009443 ATP binding site [chemical binding]; other site 204669009444 Mg2+ binding site [ion binding]; other site 204669009445 G-X-G motif; other site 204669009446 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 204669009447 hydroxyglutarate oxidase; Provisional; Region: PRK11728 204669009448 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 204669009449 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 204669009450 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 204669009451 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 204669009452 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 204669009453 active site 204669009454 catalytic site [active] 204669009455 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 204669009456 Penicillinase repressor; Region: Pencillinase_R; pfam03965 204669009457 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 204669009458 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 204669009459 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 204669009460 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 204669009461 protein binding site [polypeptide binding]; other site 204669009462 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 204669009463 protein binding site [polypeptide binding]; other site 204669009464 Bacterial sugar transferase; Region: Bac_transf; pfam02397 204669009465 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 204669009466 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 204669009467 inhibitor-cofactor binding pocket; inhibition site 204669009468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669009469 catalytic residue [active] 204669009470 Methyltransferase domain; Region: Methyltransf_31; pfam13847 204669009471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669009472 S-adenosylmethionine binding site [chemical binding]; other site 204669009473 putative glycosyl transferase; Provisional; Region: PRK10307 204669009474 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 204669009475 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 204669009476 active site 204669009477 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 204669009478 homodimer interface [polypeptide binding]; other site 204669009479 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 204669009480 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 204669009481 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 204669009482 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 204669009483 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 204669009484 Chain length determinant protein; Region: Wzz; cl15801 204669009485 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 204669009486 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 204669009487 P-loop; other site 204669009488 Magnesium ion binding site [ion binding]; other site 204669009489 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 204669009490 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 204669009491 SLBB domain; Region: SLBB; pfam10531 204669009492 SLBB domain; Region: SLBB; pfam10531 204669009493 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 204669009494 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 204669009495 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 204669009496 inhibitor-cofactor binding pocket; inhibition site 204669009497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669009498 catalytic residue [active] 204669009499 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 204669009500 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 204669009501 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 204669009502 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 204669009503 putative trimer interface [polypeptide binding]; other site 204669009504 putative active site [active] 204669009505 putative substrate binding site [chemical binding]; other site 204669009506 putative CoA binding site [chemical binding]; other site 204669009507 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 204669009508 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 204669009509 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 204669009510 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 204669009511 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 204669009512 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 204669009513 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 204669009514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 204669009515 Uncharacterized conserved protein [Function unknown]; Region: COG2308 204669009516 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669009517 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 204669009518 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 204669009519 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669009520 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 204669009521 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 204669009522 Walker A/P-loop; other site 204669009523 ATP binding site [chemical binding]; other site 204669009524 Q-loop/lid; other site 204669009525 ABC transporter signature motif; other site 204669009526 Walker B; other site 204669009527 D-loop; other site 204669009528 H-loop/switch region; other site 204669009529 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 204669009530 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 204669009531 putative active site [active] 204669009532 putative metal binding site [ion binding]; other site 204669009533 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 204669009534 Cna protein B-type domain; Region: Cna_B_2; pfam13715 204669009535 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 204669009536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 204669009537 motif II; other site 204669009538 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 204669009539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 204669009540 DinB family; Region: DinB; cl17821 204669009541 DinB superfamily; Region: DinB_2; pfam12867 204669009542 DinB superfamily; Region: DinB_2; pfam12867 204669009543 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 204669009544 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 204669009545 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 204669009546 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 204669009547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669009548 dimerization interface [polypeptide binding]; other site 204669009549 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 204669009550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669009551 Zn2+ binding site [ion binding]; other site 204669009552 Mg2+ binding site [ion binding]; other site 204669009553 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 204669009554 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 204669009555 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 204669009556 P loop; other site 204669009557 GTP binding site [chemical binding]; other site 204669009558 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 204669009559 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 204669009560 catalytic motif [active] 204669009561 Zn binding site [ion binding]; other site 204669009562 RibD C-terminal domain; Region: RibD_C; cl17279 204669009563 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 204669009564 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 204669009565 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 204669009566 active site 204669009567 interdomain interaction site; other site 204669009568 putative metal-binding site [ion binding]; other site 204669009569 nucleotide binding site [chemical binding]; other site 204669009570 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 204669009571 domain I; other site 204669009572 DNA binding groove [nucleotide binding] 204669009573 phosphate binding site [ion binding]; other site 204669009574 domain II; other site 204669009575 domain III; other site 204669009576 nucleotide binding site [chemical binding]; other site 204669009577 catalytic site [active] 204669009578 domain IV; other site 204669009579 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 204669009580 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 204669009581 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 204669009582 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 204669009583 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 204669009584 DNA protecting protein DprA; Region: dprA; TIGR00732 204669009585 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 204669009586 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 204669009587 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669009588 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 204669009589 metal ion-dependent adhesion site (MIDAS); other site 204669009590 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 204669009591 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 204669009592 RNA binding surface [nucleotide binding]; other site 204669009593 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 204669009594 active site 204669009595 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 204669009596 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 204669009597 iron-sulfur cluster [ion binding]; other site 204669009598 [2Fe-2S] cluster binding site [ion binding]; other site 204669009599 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 204669009600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669009601 S-adenosylmethionine binding site [chemical binding]; other site 204669009602 glycogen synthase; Provisional; Region: glgA; PRK00654 204669009603 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 204669009604 ADP-binding pocket [chemical binding]; other site 204669009605 homodimer interface [polypeptide binding]; other site 204669009606 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669009607 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669009608 FtsX-like permease family; Region: FtsX; pfam02687 204669009609 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669009610 FtsX-like permease family; Region: FtsX; pfam02687 204669009611 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 204669009612 hypothetical protein; Provisional; Region: PHA02764 204669009613 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 204669009614 Na binding site [ion binding]; other site 204669009615 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 204669009616 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 204669009617 Fe-S cluster binding site [ion binding]; other site 204669009618 active site 204669009619 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669009620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669009621 active site 204669009622 phosphorylation site [posttranslational modification] 204669009623 intermolecular recognition site; other site 204669009624 dimerization interface [polypeptide binding]; other site 204669009625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669009626 Walker A motif; other site 204669009627 ATP binding site [chemical binding]; other site 204669009628 Walker B motif; other site 204669009629 arginine finger; other site 204669009630 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 204669009631 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 204669009632 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669009633 GAF domain; Region: GAF_3; pfam13492 204669009634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669009635 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 204669009636 putative active site [active] 204669009637 heme pocket [chemical binding]; other site 204669009638 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669009639 dimer interface [polypeptide binding]; other site 204669009640 phosphorylation site [posttranslational modification] 204669009641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669009642 ATP binding site [chemical binding]; other site 204669009643 Mg2+ binding site [ion binding]; other site 204669009644 G-X-G motif; other site 204669009645 NADH dehydrogenase subunit B; Validated; Region: PRK06411 204669009646 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 204669009647 putative ligand binding pocket/active site [active] 204669009648 putative metal binding site [ion binding]; other site 204669009649 FecR protein; Region: FecR; pfam04773 204669009650 N-glycosyltransferase; Provisional; Region: PRK11204 204669009651 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 204669009652 DXD motif; other site 204669009653 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 204669009654 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 204669009655 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 204669009656 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 204669009657 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 204669009658 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 204669009659 Multicopper oxidase; Region: Cu-oxidase; pfam00394 204669009660 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 204669009661 ferric uptake regulator; Provisional; Region: fur; PRK09462 204669009662 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 204669009663 metal binding site 2 [ion binding]; metal-binding site 204669009664 putative DNA binding helix; other site 204669009665 metal binding site 1 [ion binding]; metal-binding site 204669009666 dimer interface [polypeptide binding]; other site 204669009667 structural Zn2+ binding site [ion binding]; other site 204669009668 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 204669009669 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 204669009670 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669009671 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669009672 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669009673 active site 204669009674 ATP binding site [chemical binding]; other site 204669009675 substrate binding site [chemical binding]; other site 204669009676 activation loop (A-loop); other site 204669009677 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 204669009678 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 204669009679 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 204669009680 active site 204669009681 Helix-turn-helix domain; Region: HTH_17; cl17695 204669009682 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 204669009683 DnaA box-binding interface [nucleotide binding]; other site 204669009684 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055 204669009685 DnaA box-binding interface [nucleotide binding]; other site 204669009686 AAA ATPase domain; Region: AAA_16; pfam13191 204669009687 AAA domain; Region: AAA_22; pfam13401 204669009688 Integrase core domain; Region: rve; pfam00665 204669009689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669009690 salt bridge; other site 204669009691 non-specific DNA binding site [nucleotide binding]; other site 204669009692 sequence-specific DNA binding site [nucleotide binding]; other site 204669009693 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 204669009694 Catalytic site [active] 204669009695 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 204669009696 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 204669009697 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 204669009698 Terminase-like family; Region: Terminase_6; pfam03237 204669009699 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 204669009700 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 204669009701 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669009702 non-specific DNA binding site [nucleotide binding]; other site 204669009703 salt bridge; other site 204669009704 sequence-specific DNA binding site [nucleotide binding]; other site 204669009705 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 204669009706 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 204669009707 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 204669009708 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 204669009709 FAD binding site [chemical binding]; other site 204669009710 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 204669009711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 204669009712 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 204669009713 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 204669009714 active site 204669009715 DNA binding site [nucleotide binding] 204669009716 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 204669009717 DNA binding site [nucleotide binding] 204669009718 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 204669009719 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 204669009720 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 204669009721 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 204669009722 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 204669009723 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 204669009724 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 204669009725 substrate binding pocket [chemical binding]; other site 204669009726 chain length determination region; other site 204669009727 substrate-Mg2+ binding site; other site 204669009728 catalytic residues [active] 204669009729 aspartate-rich region 1; other site 204669009730 active site lid residues [active] 204669009731 aspartate-rich region 2; other site 204669009732 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 204669009733 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 204669009734 putative dimer interface [polypeptide binding]; other site 204669009735 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669009736 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 204669009737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669009738 S-adenosylmethionine binding site [chemical binding]; other site 204669009739 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 204669009740 metal-dependent hydrolase; Provisional; Region: PRK00685 204669009741 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 204669009742 active site residue [active] 204669009743 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669009744 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 204669009745 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669009746 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 204669009747 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 204669009748 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 204669009749 diaminopimelate decarboxylase; Region: lysA; TIGR01048 204669009750 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 204669009751 active site 204669009752 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 204669009753 substrate binding site [chemical binding]; other site 204669009754 catalytic residues [active] 204669009755 dimer interface [polypeptide binding]; other site 204669009756 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 204669009757 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 204669009758 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 204669009759 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 204669009760 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 204669009761 active site 204669009762 BioY family; Region: BioY; pfam02632 204669009763 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 204669009764 PilZ domain; Region: PilZ; pfam07238 204669009765 Nudix hydrolase homolog; Region: PLN02791 204669009766 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 204669009767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669009768 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669009769 DNA binding residues [nucleotide binding] 204669009770 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 204669009771 cell division protein FtsZ; Validated; Region: PRK09330 204669009772 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 204669009773 nucleotide binding site [chemical binding]; other site 204669009774 SulA interaction site; other site 204669009775 cell division protein FtsA; Region: ftsA; TIGR01174 204669009776 Cell division protein FtsA; Region: FtsA; smart00842 204669009777 Cell division protein FtsA; Region: FtsA; pfam14450 204669009778 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 204669009779 Cell division protein FtsQ; Region: FtsQ; pfam03799 204669009780 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 204669009781 putative amphipathic alpha helix; other site 204669009782 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669009783 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669009784 ligand binding site [chemical binding]; other site 204669009785 flexible hinge region; other site 204669009786 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 204669009787 putative switch regulator; other site 204669009788 non-specific DNA interactions [nucleotide binding]; other site 204669009789 DNA binding site [nucleotide binding] 204669009790 sequence specific DNA binding site [nucleotide binding]; other site 204669009791 putative cAMP binding site [chemical binding]; other site 204669009792 Transcriptional regulators [Transcription]; Region: MarR; COG1846 204669009793 MarR family; Region: MarR_2; pfam12802 204669009794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669009795 Coenzyme A binding pocket [chemical binding]; other site 204669009796 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669009797 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669009798 FtsX-like permease family; Region: FtsX; pfam02687 204669009799 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669009800 FtsX-like permease family; Region: FtsX; pfam02687 204669009801 H+ Antiporter protein; Region: 2A0121; TIGR00900 204669009802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669009803 putative substrate translocation pore; other site 204669009804 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669009805 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669009806 FtsX-like permease family; Region: FtsX; pfam02687 204669009807 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669009808 FtsX-like permease family; Region: FtsX; pfam02687 204669009809 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669009810 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 204669009811 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 204669009812 dimerization interface [polypeptide binding]; other site 204669009813 putative DNA binding site [nucleotide binding]; other site 204669009814 putative Zn2+ binding site [ion binding]; other site 204669009815 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669009816 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 204669009817 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 204669009818 putative hydrophobic ligand binding site [chemical binding]; other site 204669009819 Domain of unknown function (DU1801); Region: DUF1801; cl17490 204669009820 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 204669009821 trimer interface [polypeptide binding]; other site 204669009822 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 204669009823 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 204669009824 trimer interface [polypeptide binding]; other site 204669009825 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 204669009826 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 204669009827 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669009828 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669009829 FtsX-like permease family; Region: FtsX; pfam02687 204669009830 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669009831 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 204669009832 TIR domain; Region: TIR_2; pfam13676 204669009833 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 204669009834 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 204669009835 active site 204669009836 Transposase IS200 like; Region: Y1_Tnp; cl00848 204669009837 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 204669009838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669009839 Walker A/P-loop; other site 204669009840 ATP binding site [chemical binding]; other site 204669009841 ABC transporter signature motif; other site 204669009842 Walker B; other site 204669009843 D-loop; other site 204669009844 H-loop/switch region; other site 204669009845 ABC transporter; Region: ABC_tran_2; pfam12848 204669009846 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 204669009847 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669009848 PAS domain; Region: PAS_9; pfam13426 204669009849 putative active site [active] 204669009850 heme pocket [chemical binding]; other site 204669009851 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 204669009852 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 204669009853 metal binding site [ion binding]; metal-binding site 204669009854 active site 204669009855 I-site; other site 204669009856 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 204669009857 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 204669009858 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 204669009859 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 204669009860 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 204669009861 ligand binding site [chemical binding]; other site 204669009862 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 204669009863 PA_M28_1_3: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 3. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_3; cd04822 204669009864 PA/protease or protease-like domain interface [polypeptide binding]; other site 204669009865 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 204669009866 Peptidase family M28; Region: Peptidase_M28; pfam04389 204669009867 metal binding site [ion binding]; metal-binding site 204669009868 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 204669009869 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669009870 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669009871 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669009872 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669009873 PilZ domain; Region: PilZ; pfam07238 204669009874 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 204669009875 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 204669009876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669009877 active site 204669009878 phosphorylation site [posttranslational modification] 204669009879 intermolecular recognition site; other site 204669009880 dimerization interface [polypeptide binding]; other site 204669009881 LytTr DNA-binding domain; Region: LytTR; smart00850 204669009882 Histidine kinase; Region: His_kinase; pfam06580 204669009883 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 204669009884 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 204669009885 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669009886 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669009887 active site 204669009888 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 204669009889 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 204669009890 dimer interface [polypeptide binding]; other site 204669009891 active site 204669009892 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 204669009893 A functionally uncharacterized subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in...; Region: GH20_chitobiase-like_1; cd06570 204669009894 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 204669009895 active site 204669009896 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 204669009897 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 204669009898 NAD binding site [chemical binding]; other site 204669009899 homotetramer interface [polypeptide binding]; other site 204669009900 homodimer interface [polypeptide binding]; other site 204669009901 active site 204669009902 substrate binding site [chemical binding]; other site 204669009903 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 204669009904 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 204669009905 B12 binding site [chemical binding]; other site 204669009906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669009907 FeS/SAM binding site; other site 204669009908 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 204669009909 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 204669009910 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 204669009911 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 204669009912 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; Region: NGN_SP_TaA; cd09893 204669009913 transcriptional activator RfaH; Region: RfaH; TIGR01955 204669009914 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 204669009915 heterodimer interface [polypeptide binding]; other site 204669009916 homodimer interface [polypeptide binding]; other site 204669009917 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 204669009918 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 204669009919 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669009920 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669009921 FtsX-like permease family; Region: FtsX; pfam02687 204669009922 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669009923 FtsX-like permease family; Region: FtsX; pfam02687 204669009924 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 204669009925 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 204669009926 FMN binding site [chemical binding]; other site 204669009927 substrate binding site [chemical binding]; other site 204669009928 putative catalytic residue [active] 204669009929 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669009930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669009931 active site 204669009932 phosphorylation site [posttranslational modification] 204669009933 intermolecular recognition site; other site 204669009934 dimerization interface [polypeptide binding]; other site 204669009935 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669009936 DNA binding residues [nucleotide binding] 204669009937 dimerization interface [polypeptide binding]; other site 204669009938 CHASE3 domain; Region: CHASE3; pfam05227 204669009939 PAS domain S-box; Region: sensory_box; TIGR00229 204669009940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669009941 putative active site [active] 204669009942 heme pocket [chemical binding]; other site 204669009943 PAS domain S-box; Region: sensory_box; TIGR00229 204669009944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669009945 putative active site [active] 204669009946 heme pocket [chemical binding]; other site 204669009947 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669009948 GAF domain; Region: GAF; pfam01590 204669009949 PAS domain S-box; Region: sensory_box; TIGR00229 204669009950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669009951 putative active site [active] 204669009952 heme pocket [chemical binding]; other site 204669009953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669009954 dimer interface [polypeptide binding]; other site 204669009955 phosphorylation site [posttranslational modification] 204669009956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669009957 ATP binding site [chemical binding]; other site 204669009958 Mg2+ binding site [ion binding]; other site 204669009959 G-X-G motif; other site 204669009960 Response regulator receiver domain; Region: Response_reg; pfam00072 204669009961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669009962 active site 204669009963 phosphorylation site [posttranslational modification] 204669009964 intermolecular recognition site; other site 204669009965 dimerization interface [polypeptide binding]; other site 204669009966 Hpt domain; Region: Hpt; pfam01627 204669009967 Response regulator receiver domain; Region: Response_reg; pfam00072 204669009968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669009969 active site 204669009970 phosphorylation site [posttranslational modification] 204669009971 intermolecular recognition site; other site 204669009972 dimerization interface [polypeptide binding]; other site 204669009973 Response regulator receiver domain; Region: Response_reg; pfam00072 204669009974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669009975 active site 204669009976 phosphorylation site [posttranslational modification] 204669009977 intermolecular recognition site; other site 204669009978 dimerization interface [polypeptide binding]; other site 204669009979 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 204669009980 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 204669009981 metal binding site [ion binding]; metal-binding site 204669009982 active site 204669009983 I-site; other site 204669009984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669009985 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669009986 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 204669009987 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 204669009988 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 204669009989 TPP-binding site [chemical binding]; other site 204669009990 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 204669009991 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 204669009992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669009993 NAD(P) binding site [chemical binding]; other site 204669009994 active site 204669009995 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 204669009996 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669009997 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669009998 DNA binding residues [nucleotide binding] 204669009999 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 204669010000 Uncharacterized conserved protein [Function unknown]; Region: COG2128 204669010001 PAS fold; Region: PAS_4; pfam08448 204669010002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669010003 dimer interface [polypeptide binding]; other site 204669010004 phosphorylation site [posttranslational modification] 204669010005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669010006 ATP binding site [chemical binding]; other site 204669010007 Mg2+ binding site [ion binding]; other site 204669010008 G-X-G motif; other site 204669010009 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 204669010010 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 204669010011 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 204669010012 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 204669010013 Protein of unknown function (DUF962); Region: DUF962; pfam06127 204669010014 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669010015 GAF domain; Region: GAF; pfam01590 204669010016 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669010017 GAF domain; Region: GAF; pfam01590 204669010018 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669010019 PAS fold; Region: PAS_3; pfam08447 204669010020 putative active site [active] 204669010021 heme pocket [chemical binding]; other site 204669010022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669010023 heme pocket [chemical binding]; other site 204669010024 putative active site [active] 204669010025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669010026 PAS fold; Region: PAS_3; pfam08447 204669010027 putative active site [active] 204669010028 heme pocket [chemical binding]; other site 204669010029 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 204669010030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669010031 dimer interface [polypeptide binding]; other site 204669010032 phosphorylation site [posttranslational modification] 204669010033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669010034 ATP binding site [chemical binding]; other site 204669010035 Mg2+ binding site [ion binding]; other site 204669010036 G-X-G motif; other site 204669010037 acetyl-CoA synthetase; Provisional; Region: PRK00174 204669010038 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 204669010039 active site 204669010040 CoA binding site [chemical binding]; other site 204669010041 acyl-activating enzyme (AAE) consensus motif; other site 204669010042 AMP binding site [chemical binding]; other site 204669010043 acetate binding site [chemical binding]; other site 204669010044 acetyl-CoA synthetase; Provisional; Region: PRK00174 204669010045 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 204669010046 acyl-activating enzyme (AAE) consensus motif; other site 204669010047 AMP binding site [chemical binding]; other site 204669010048 active site 204669010049 CoA binding site [chemical binding]; other site 204669010050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 204669010051 Glyco_18 domain; Region: Glyco_18; smart00636 204669010052 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 204669010053 active site 204669010054 Response regulator receiver domain; Region: Response_reg; pfam00072 204669010055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669010056 active site 204669010057 phosphorylation site [posttranslational modification] 204669010058 intermolecular recognition site; other site 204669010059 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 204669010060 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 204669010061 homodimer interface [polypeptide binding]; other site 204669010062 TPR repeat; Region: TPR_11; pfam13414 204669010063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669010064 binding surface 204669010065 TPR motif; other site 204669010066 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 204669010067 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 204669010068 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 204669010069 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 204669010070 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 204669010071 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 204669010072 E3 interaction surface; other site 204669010073 lipoyl attachment site [posttranslational modification]; other site 204669010074 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669010075 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 204669010076 Domain of unknown function DUF21; Region: DUF21; pfam01595 204669010077 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 204669010078 Transporter associated domain; Region: CorC_HlyC; smart01091 204669010079 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 204669010080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 204669010081 dimer interface [polypeptide binding]; other site 204669010082 conserved gate region; other site 204669010083 putative PBP binding loops; other site 204669010084 ABC-ATPase subunit interface; other site 204669010085 GTPase Era; Reviewed; Region: era; PRK00089 204669010086 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 204669010087 G1 box; other site 204669010088 GTP/Mg2+ binding site [chemical binding]; other site 204669010089 Switch I region; other site 204669010090 G2 box; other site 204669010091 Switch II region; other site 204669010092 G3 box; other site 204669010093 G4 box; other site 204669010094 G5 box; other site 204669010095 KH domain; Region: KH_2; pfam07650 204669010096 gliding motility-associated protein GldE; Region: GldE; TIGR03520 204669010097 Domain of unknown function DUF21; Region: DUF21; pfam01595 204669010098 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 204669010099 Transporter associated domain; Region: CorC_HlyC; smart01091 204669010100 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 204669010101 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 204669010102 PhoH-like protein; Region: PhoH; pfam02562 204669010103 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 204669010104 ATP binding site [chemical binding]; other site 204669010105 putative Mg++ binding site [ion binding]; other site 204669010106 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 204669010107 nucleotide binding region [chemical binding]; other site 204669010108 ATP-binding site [chemical binding]; other site 204669010109 HRDC domain; Region: HRDC; pfam00570 204669010110 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 204669010111 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669010112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669010113 DNA binding site [nucleotide binding] 204669010114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669010115 binding surface 204669010116 TPR motif; other site 204669010117 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669010118 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669010119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669010120 TPR motif; other site 204669010121 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669010122 binding surface 204669010123 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 204669010124 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 204669010125 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 204669010126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669010127 Coenzyme A binding pocket [chemical binding]; other site 204669010128 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 204669010129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669010130 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 204669010131 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 204669010132 BON domain; Region: BON; pfam04972 204669010133 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 204669010134 TPR repeat; Region: TPR_11; pfam13414 204669010135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669010136 binding surface 204669010137 TPR motif; other site 204669010138 TPR repeat; Region: TPR_11; pfam13414 204669010139 Predicted transcriptional regulator [Transcription]; Region: COG3905 204669010140 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 204669010141 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669010142 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 204669010143 metal ion-dependent adhesion site (MIDAS); other site 204669010144 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 204669010145 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669010146 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 204669010147 Predicted membrane protein [Function unknown]; Region: COG4709 204669010148 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 204669010149 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 204669010150 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 204669010151 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669010152 FtsX-like permease family; Region: FtsX; pfam02687 204669010153 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 204669010154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669010155 Walker A/P-loop; other site 204669010156 ATP binding site [chemical binding]; other site 204669010157 Q-loop/lid; other site 204669010158 ABC transporter signature motif; other site 204669010159 Walker B; other site 204669010160 D-loop; other site 204669010161 H-loop/switch region; other site 204669010162 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 204669010163 Walker A/P-loop; other site 204669010164 ATP binding site [chemical binding]; other site 204669010165 ABC transporter; Region: ABC_tran; pfam00005 204669010166 Q-loop/lid; other site 204669010167 ABC transporter signature motif; other site 204669010168 Walker B; other site 204669010169 D-loop; other site 204669010170 H-loop/switch region; other site 204669010171 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 204669010172 Clp amino terminal domain; Region: Clp_N; pfam02861 204669010173 Clp amino terminal domain; Region: Clp_N; pfam02861 204669010174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669010175 Walker A motif; other site 204669010176 ATP binding site [chemical binding]; other site 204669010177 Walker B motif; other site 204669010178 arginine finger; other site 204669010179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669010180 Walker A motif; other site 204669010181 ATP binding site [chemical binding]; other site 204669010182 Walker B motif; other site 204669010183 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 204669010184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 204669010185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 204669010186 DoxX-like family; Region: DoxX_2; pfam13564 204669010187 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 204669010188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669010189 NAD(P) binding site [chemical binding]; other site 204669010190 active site 204669010191 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 204669010192 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 204669010193 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 204669010194 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 204669010195 Uncharacterized conserved protein [Function unknown]; Region: COG3391 204669010196 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 204669010197 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 204669010198 dimer interface [polypeptide binding]; other site 204669010199 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669010200 ligand binding site [chemical binding]; other site 204669010201 Methyltransferase domain; Region: Methyltransf_23; pfam13489 204669010202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669010203 S-adenosylmethionine binding site [chemical binding]; other site 204669010204 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 204669010205 Helix-turn-helix domain; Region: HTH_37; pfam13744 204669010206 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 204669010207 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669010208 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669010209 FtsX-like permease family; Region: FtsX; pfam02687 204669010210 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669010211 FtsX-like permease family; Region: FtsX; pfam02687 204669010212 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 204669010213 Interdomain contacts; other site 204669010214 DinB superfamily; Region: DinB_2; pfam12867 204669010215 Family description; Region: VCBS; pfam13517 204669010216 Family description; Region: VCBS; pfam13517 204669010217 Family description; Region: VCBS; pfam13517 204669010218 Family description; Region: VCBS; pfam13517 204669010219 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 204669010220 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 204669010221 SnoaL-like domain; Region: SnoaL_3; pfam13474 204669010222 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 204669010223 EVE domain; Region: EVE; pfam01878 204669010224 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 204669010225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669010226 dimer interface [polypeptide binding]; other site 204669010227 phosphorylation site [posttranslational modification] 204669010228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669010229 ATP binding site [chemical binding]; other site 204669010230 Mg2+ binding site [ion binding]; other site 204669010231 G-X-G motif; other site 204669010232 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669010233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669010234 active site 204669010235 phosphorylation site [posttranslational modification] 204669010236 intermolecular recognition site; other site 204669010237 dimerization interface [polypeptide binding]; other site 204669010238 TPR repeat; Region: TPR_11; pfam13414 204669010239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669010240 binding surface 204669010241 TPR motif; other site 204669010242 TPR repeat; Region: TPR_11; pfam13414 204669010243 TPR repeat; Region: TPR_11; pfam13414 204669010244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669010245 binding surface 204669010246 TPR motif; other site 204669010247 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669010248 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 204669010249 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669010250 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669010251 FtsX-like permease family; Region: FtsX; pfam02687 204669010252 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669010253 FtsX-like permease family; Region: FtsX; pfam02687 204669010254 translation elongation factor P; Region: efp; TIGR00038 204669010255 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 204669010256 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 204669010257 RNA binding site [nucleotide binding]; other site 204669010258 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 204669010259 RNA binding site [nucleotide binding]; other site 204669010260 Acylphosphatase; Region: Acylphosphatase; pfam00708 204669010261 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 204669010262 active site 204669010263 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669010264 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669010265 FtsX-like permease family; Region: FtsX; pfam02687 204669010266 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669010267 FtsX-like permease family; Region: FtsX; pfam02687 204669010268 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 204669010269 UbiA prenyltransferase family; Region: UbiA; pfam01040 204669010270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669010271 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 204669010272 NAD(P) binding site [chemical binding]; other site 204669010273 active site 204669010274 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 204669010275 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 204669010276 hinge; other site 204669010277 active site 204669010278 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669010279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669010280 binding surface 204669010281 TPR motif; other site 204669010282 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 204669010283 active site 204669010284 putative DNA-binding cleft [nucleotide binding]; other site 204669010285 dimer interface [polypeptide binding]; other site 204669010286 carbon starvation protein A; Provisional; Region: PRK15015 204669010287 Carbon starvation protein CstA; Region: CstA; pfam02554 204669010288 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 204669010289 Response regulator receiver domain; Region: Response_reg; pfam00072 204669010290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669010291 active site 204669010292 phosphorylation site [posttranslational modification] 204669010293 intermolecular recognition site; other site 204669010294 dimerization interface [polypeptide binding]; other site 204669010295 probable DNA repair protein; Region: TIGR03623 204669010296 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 204669010297 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 204669010298 Part of AAA domain; Region: AAA_19; pfam13245 204669010299 Family description; Region: UvrD_C_2; pfam13538 204669010300 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 204669010301 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 204669010302 transmembrane helices; other site 204669010303 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 204669010304 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 204669010305 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 204669010306 diiron binding motif [ion binding]; other site 204669010307 Uncharacterized conserved protein [Function unknown]; Region: COG1633 204669010308 CCC1-related protein family; Region: CCC1_like_1; cd02437 204669010309 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 204669010310 active site 204669010311 catalytic residues [active] 204669010312 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 204669010313 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 204669010314 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 204669010315 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 204669010316 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 204669010317 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 204669010318 active site 204669010319 homodimer interface [polypeptide binding]; other site 204669010320 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 204669010321 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 204669010322 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 204669010323 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 204669010324 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 204669010325 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 204669010326 Mg++ binding site [ion binding]; other site 204669010327 putative catalytic motif [active] 204669010328 putative substrate binding site [chemical binding]; other site 204669010329 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 204669010330 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 204669010331 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 204669010332 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 204669010333 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 204669010334 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 204669010335 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 204669010336 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 204669010337 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 204669010338 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 204669010339 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 204669010340 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 204669010341 Cell division protein FtsL; Region: FtsL; cl11433 204669010342 MraW methylase family; Region: Methyltransf_5; cl17771 204669010343 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 204669010344 mraZ protein; Region: TIGR00242 204669010345 MraZ protein; Region: MraZ; pfam02381 204669010346 MraZ protein; Region: MraZ; pfam02381 204669010347 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 204669010348 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 204669010349 hypothetical protein; Provisional; Region: PRK11239 204669010350 Protein of unknown function, DUF480; Region: DUF480; pfam04337 204669010351 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 204669010352 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669010353 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669010354 FtsX-like permease family; Region: FtsX; pfam02687 204669010355 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669010356 FtsX-like permease family; Region: FtsX; pfam02687 204669010357 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 204669010358 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 204669010359 Ligand Binding Site [chemical binding]; other site 204669010360 Hemerythrin; Region: Hemerythrin; cd12107 204669010361 Fe binding site [ion binding]; other site 204669010362 Hemerythrin; Region: Hemerythrin; cd12107 204669010363 Fe binding site [ion binding]; other site 204669010364 Hemerythrin; Region: Hemerythrin; cd12107 204669010365 Fe binding site [ion binding]; other site 204669010366 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 204669010367 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 204669010368 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 204669010369 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 204669010370 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 204669010371 active site 204669010372 catalytic tetrad [active] 204669010373 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 204669010374 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 204669010375 active site 204669010376 catalytic tetrad [active] 204669010377 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 204669010378 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 204669010379 homodimer interface [polypeptide binding]; other site 204669010380 homotetramer interface [polypeptide binding]; other site 204669010381 active site pocket [active] 204669010382 cleavage site 204669010383 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669010384 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669010385 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 204669010386 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 204669010387 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 204669010388 metal binding site [ion binding]; metal-binding site 204669010389 active site 204669010390 I-site; other site 204669010391 Helix-turn-helix domain; Region: HTH_25; pfam13413 204669010392 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 204669010393 S-adenosylmethionine synthetase; Validated; Region: PRK05250 204669010394 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 204669010395 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 204669010396 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 204669010397 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 204669010398 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 204669010399 homotetramer interface [polypeptide binding]; other site 204669010400 ligand binding site [chemical binding]; other site 204669010401 catalytic site [active] 204669010402 NAD binding site [chemical binding]; other site 204669010403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 204669010404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 204669010405 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 204669010406 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 204669010407 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669010408 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669010409 DNA binding residues [nucleotide binding] 204669010410 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 204669010411 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 204669010412 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 204669010413 CTP synthetase; Validated; Region: pyrG; PRK05380 204669010414 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 204669010415 Catalytic site [active] 204669010416 active site 204669010417 UTP binding site [chemical binding]; other site 204669010418 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 204669010419 active site 204669010420 putative oxyanion hole; other site 204669010421 catalytic triad [active] 204669010422 EamA-like transporter family; Region: EamA; pfam00892 204669010423 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 204669010424 EamA-like transporter family; Region: EamA; pfam00892 204669010425 Uncharacterized conserved protein [Function unknown]; Region: COG3538 204669010426 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 204669010427 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 204669010428 NmrA-like family; Region: NmrA; pfam05368 204669010429 NADP binding site [chemical binding]; other site 204669010430 active site 204669010431 regulatory binding site [polypeptide binding]; other site 204669010432 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 204669010433 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 204669010434 Domain of unknown function (DUF3601); Region: DUF3601; pfam12208 204669010435 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 204669010436 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 204669010437 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 204669010438 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 204669010439 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 204669010440 active site 204669010441 dimer interface [polypeptide binding]; other site 204669010442 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 204669010443 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 204669010444 active site 204669010445 FMN binding site [chemical binding]; other site 204669010446 substrate binding site [chemical binding]; other site 204669010447 3Fe-4S cluster binding site [ion binding]; other site 204669010448 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 204669010449 domain interface; other site 204669010450 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 204669010451 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 204669010452 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 204669010453 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 204669010454 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 204669010455 histidinol dehydrogenase; Region: hisD; TIGR00069 204669010456 NAD binding site [chemical binding]; other site 204669010457 dimerization interface [polypeptide binding]; other site 204669010458 product binding site; other site 204669010459 substrate binding site [chemical binding]; other site 204669010460 zinc binding site [ion binding]; other site 204669010461 catalytic residues [active] 204669010462 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 204669010463 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 204669010464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669010465 homodimer interface [polypeptide binding]; other site 204669010466 catalytic residue [active] 204669010467 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 204669010468 putative active site pocket [active] 204669010469 4-fold oligomerization interface [polypeptide binding]; other site 204669010470 metal binding residues [ion binding]; metal-binding site 204669010471 3-fold/trimer interface [polypeptide binding]; other site 204669010472 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 204669010473 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 204669010474 putative active site [active] 204669010475 oxyanion strand; other site 204669010476 catalytic triad [active] 204669010477 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 204669010478 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 204669010479 substrate binding site [chemical binding]; other site 204669010480 glutamase interaction surface [polypeptide binding]; other site 204669010481 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 204669010482 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 204669010483 catalytic residues [active] 204669010484 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 204669010485 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 204669010486 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 204669010487 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 204669010488 ABC transporter; Region: ABC_tran_2; pfam12848 204669010489 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 204669010490 Protein of unknown function, DUF481; Region: DUF481; pfam04338 204669010491 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 204669010492 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 204669010493 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 204669010494 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 204669010495 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 204669010496 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 204669010497 Ligand binding site [chemical binding]; other site 204669010498 Electron transfer flavoprotein domain; Region: ETF; pfam01012 204669010499 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 204669010500 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 204669010501 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 204669010502 Uncharacterized conserved protein [Function unknown]; Region: COG2353 204669010503 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 204669010504 Ferritin-like domain; Region: Ferritin_2; pfam13668 204669010505 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669010506 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 204669010507 putative active site [active] 204669010508 transaldolase; Provisional; Region: PRK03903 204669010509 catalytic residue [active] 204669010510 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 204669010511 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 204669010512 RNA polymerase sigma factor; Provisional; Region: PRK11922 204669010513 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669010514 PAS domain S-box; Region: sensory_box; TIGR00229 204669010515 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669010516 putative active site [active] 204669010517 heme pocket [chemical binding]; other site 204669010518 PAS fold; Region: PAS_4; pfam08448 204669010519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669010520 putative active site [active] 204669010521 heme pocket [chemical binding]; other site 204669010522 PAS domain S-box; Region: sensory_box; TIGR00229 204669010523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669010524 putative active site [active] 204669010525 heme pocket [chemical binding]; other site 204669010526 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669010527 DNA binding residues [nucleotide binding] 204669010528 dimerization interface [polypeptide binding]; other site 204669010529 GAF domain; Region: GAF_3; pfam13492 204669010530 GAF domain; Region: GAF_2; pfam13185 204669010531 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669010532 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 204669010533 putative active site [active] 204669010534 heme pocket [chemical binding]; other site 204669010535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669010536 putative active site [active] 204669010537 heme pocket [chemical binding]; other site 204669010538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669010539 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 204669010540 putative active site [active] 204669010541 heme pocket [chemical binding]; other site 204669010542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669010543 dimer interface [polypeptide binding]; other site 204669010544 phosphorylation site [posttranslational modification] 204669010545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669010546 ATP binding site [chemical binding]; other site 204669010547 Mg2+ binding site [ion binding]; other site 204669010548 G-X-G motif; other site 204669010549 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 204669010550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669010551 active site 204669010552 phosphorylation site [posttranslational modification] 204669010553 intermolecular recognition site; other site 204669010554 dimerization interface [polypeptide binding]; other site 204669010555 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669010556 DNA binding residues [nucleotide binding] 204669010557 dimerization interface [polypeptide binding]; other site 204669010558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669010559 active site 204669010560 phosphorylation site [posttranslational modification] 204669010561 intermolecular recognition site; other site 204669010562 dimerization interface [polypeptide binding]; other site 204669010563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669010564 Response regulator receiver domain; Region: Response_reg; pfam00072 204669010565 active site 204669010566 phosphorylation site [posttranslational modification] 204669010567 intermolecular recognition site; other site 204669010568 dimerization interface [polypeptide binding]; other site 204669010569 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669010570 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 204669010571 PAS domain S-box; Region: sensory_box; TIGR00229 204669010572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669010573 putative active site [active] 204669010574 heme pocket [chemical binding]; other site 204669010575 GAF domain; Region: GAF_3; pfam13492 204669010576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669010577 dimer interface [polypeptide binding]; other site 204669010578 phosphorylation site [posttranslational modification] 204669010579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669010580 ATP binding site [chemical binding]; other site 204669010581 G-X-G motif; other site 204669010582 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 204669010583 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 204669010584 dimerization interface [polypeptide binding]; other site 204669010585 DPS ferroxidase diiron center [ion binding]; other site 204669010586 ion pore; other site 204669010587 Protein of unknown function, DUF417; Region: DUF417; cl01162 204669010588 DoxX; Region: DoxX; cl17842 204669010589 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 204669010590 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 204669010591 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 204669010592 putative NAD(P) binding site [chemical binding]; other site 204669010593 Predicted acetyltransferase [General function prediction only]; Region: COG2388 204669010594 Cupin domain; Region: Cupin_2; pfam07883 204669010595 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 204669010596 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 204669010597 Moco binding site; other site 204669010598 metal coordination site [ion binding]; other site 204669010599 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 204669010600 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 204669010601 FAD binding pocket [chemical binding]; other site 204669010602 FAD binding motif [chemical binding]; other site 204669010603 phosphate binding motif [ion binding]; other site 204669010604 beta-alpha-beta structure motif; other site 204669010605 NAD binding pocket [chemical binding]; other site 204669010606 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 204669010607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669010608 Walker A motif; other site 204669010609 ATP binding site [chemical binding]; other site 204669010610 Walker B motif; other site 204669010611 arginine finger; other site 204669010612 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 204669010613 Response regulator receiver domain; Region: Response_reg; pfam00072 204669010614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669010615 active site 204669010616 phosphorylation site [posttranslational modification] 204669010617 intermolecular recognition site; other site 204669010618 dimerization interface [polypeptide binding]; other site 204669010619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669010620 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 204669010621 active site 204669010622 phosphorylation site [posttranslational modification] 204669010623 intermolecular recognition site; other site 204669010624 dimerization interface [polypeptide binding]; other site 204669010625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669010626 DNA binding residues [nucleotide binding] 204669010627 dimerization interface [polypeptide binding]; other site 204669010628 DoxX; Region: DoxX; cl17842 204669010629 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 204669010630 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 204669010631 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 204669010632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669010633 putative substrate translocation pore; other site 204669010634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 204669010635 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669010636 active site 204669010637 phosphorylation site [posttranslational modification] 204669010638 intermolecular recognition site; other site 204669010639 dimerization interface [polypeptide binding]; other site 204669010640 methionine sulfoxide reductase A; Provisional; Region: PRK13014 204669010641 methionine sulfoxide reductase B; Provisional; Region: PRK00222 204669010642 SelR domain; Region: SelR; pfam01641 204669010643 methionine sulfoxide reductase A; Provisional; Region: PRK14054 204669010644 short chain dehydrogenase; Provisional; Region: PRK06500 204669010645 classical (c) SDRs; Region: SDR_c; cd05233 204669010646 NAD(P) binding site [chemical binding]; other site 204669010647 active site 204669010648 XapX domain; Region: XapX; TIGR03510 204669010649 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 204669010650 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 204669010651 dimerization interface [polypeptide binding]; other site 204669010652 DPS ferroxidase diiron center [ion binding]; other site 204669010653 ion pore; other site 204669010654 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 204669010655 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 204669010656 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 204669010657 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 204669010658 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 204669010659 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669010660 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669010661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669010662 active site 204669010663 phosphorylation site [posttranslational modification] 204669010664 intermolecular recognition site; other site 204669010665 dimerization interface [polypeptide binding]; other site 204669010666 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669010667 DNA binding residues [nucleotide binding] 204669010668 dimerization interface [polypeptide binding]; other site 204669010669 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 204669010670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 204669010671 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 204669010672 Histidine kinase; Region: HisKA_3; pfam07730 204669010673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669010674 ATP binding site [chemical binding]; other site 204669010675 Mg2+ binding site [ion binding]; other site 204669010676 G-X-G motif; other site 204669010677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669010678 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 204669010679 Walker A motif; other site 204669010680 ATP binding site [chemical binding]; other site 204669010681 Walker B motif; other site 204669010682 arginine finger; other site 204669010683 Transposase; Region: DEDD_Tnp_IS110; pfam01548 204669010684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 204669010685 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 204669010686 D5 N terminal like; Region: D5_N; smart00885 204669010687 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 204669010688 5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736 204669010689 EVE domain; Region: EVE; cl00728 204669010690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669010691 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 204669010692 Walker A motif; other site 204669010693 ATP binding site [chemical binding]; other site 204669010694 Walker B motif; other site 204669010695 arginine finger; other site 204669010696 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 204669010697 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 204669010698 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 204669010699 ATP binding site [chemical binding]; other site 204669010700 putative Mg++ binding site [ion binding]; other site 204669010701 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 204669010702 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 204669010703 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 204669010704 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 204669010705 HsdM N-terminal domain; Region: HsdM_N; pfam12161 204669010706 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 204669010707 Methyltransferase domain; Region: Methyltransf_26; pfam13659 204669010708 HNH endonuclease; Region: HNH; pfam01844 204669010709 SEC-C motif; Region: SEC-C; pfam02810 204669010710 Protein of unknown function DUF91; Region: DUF91; cl00709 204669010711 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 204669010712 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 204669010713 active site 204669010714 catalytic residues [active] 204669010715 DNA binding site [nucleotide binding] 204669010716 Int/Topo IB signature motif; other site 204669010717 ParB-like nuclease domain; Region: ParB; smart00470 204669010718 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 204669010719 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 204669010720 heme binding site [chemical binding]; other site 204669010721 ferroxidase pore; other site 204669010722 ferroxidase diiron center [ion binding]; other site 204669010723 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669010724 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669010725 DNA binding residues [nucleotide binding] 204669010726 dimerization interface [polypeptide binding]; other site 204669010727 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 204669010728 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 204669010729 TPR repeat; Region: TPR_11; pfam13414 204669010730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669010731 binding surface 204669010732 TPR repeat; Region: TPR_11; pfam13414 204669010733 TPR motif; other site 204669010734 TPR repeat; Region: TPR_11; pfam13414 204669010735 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 204669010736 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 204669010737 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 204669010738 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 204669010739 ATP binding site [chemical binding]; other site 204669010740 putative Mg++ binding site [ion binding]; other site 204669010741 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 204669010742 nucleotide binding region [chemical binding]; other site 204669010743 ATP-binding site [chemical binding]; other site 204669010744 DEAD/H associated; Region: DEAD_assoc; pfam08494 204669010745 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 204669010746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 204669010747 primosomal protein N' Region: priA; TIGR00595 204669010748 ATP binding site [chemical binding]; other site 204669010749 putative Mg++ binding site [ion binding]; other site 204669010750 helicase superfamily c-terminal domain; Region: HELICc; smart00490 204669010751 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 204669010752 Fe-S cluster binding site [ion binding]; other site 204669010753 active site 204669010754 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 204669010755 Flavoprotein; Region: Flavoprotein; pfam02441 204669010756 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 204669010757 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 204669010758 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 204669010759 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 204669010760 catalytic site [active] 204669010761 G-X2-G-X-G-K; other site 204669010762 hypothetical protein; Provisional; Region: PRK11820 204669010763 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 204669010764 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 204669010765 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 204669010766 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 204669010767 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 204669010768 Walker A/P-loop; other site 204669010769 ATP binding site [chemical binding]; other site 204669010770 Q-loop/lid; other site 204669010771 ABC transporter signature motif; other site 204669010772 Walker B; other site 204669010773 D-loop; other site 204669010774 H-loop/switch region; other site 204669010775 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 204669010776 AAA domain; Region: AAA_18; pfam13238 204669010777 EamA-like transporter family; Region: EamA; cl17759 204669010778 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 204669010779 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 204669010780 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 204669010781 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 204669010782 TDP-binding site; other site 204669010783 homodimer interface [polypeptide binding]; other site 204669010784 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 204669010785 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 204669010786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 204669010787 active site 204669010788 motif I; other site 204669010789 motif II; other site 204669010790 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 204669010791 ATP binding site [chemical binding]; other site 204669010792 substrate binding site [chemical binding]; other site 204669010793 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 204669010794 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 204669010795 active site 204669010796 nucleotide binding site [chemical binding]; other site 204669010797 HIGH motif; other site 204669010798 KMSKS motif; other site 204669010799 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 204669010800 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 204669010801 dimer interface [polypeptide binding]; other site 204669010802 active site 204669010803 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 204669010804 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 204669010805 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 204669010806 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 204669010807 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 204669010808 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 204669010809 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 204669010810 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 204669010811 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 204669010812 putative NAD(P) binding site [chemical binding]; other site 204669010813 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 204669010814 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 204669010815 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 204669010816 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 204669010817 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 204669010818 Uncharacterized conserved protein [Function unknown]; Region: COG2006 204669010819 Domain of unknown function (DUF362); Region: DUF362; pfam04015 204669010820 Uncharacterized conserved protein [Function unknown]; Region: COG2006 204669010821 Uncharacterized conserved protein [Function unknown]; Region: COG2006 204669010822 Domain of unknown function (DUF362); Region: DUF362; pfam04015 204669010823 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 204669010824 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 204669010825 O-Antigen ligase; Region: Wzy_C; pfam04932 204669010826 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 204669010827 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 204669010828 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 204669010829 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 204669010830 putative active site [active] 204669010831 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 204669010832 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 204669010833 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 204669010834 Chain length determinant protein; Region: Wzz; pfam02706 204669010835 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 204669010836 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 204669010837 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 204669010838 NAD binding site [chemical binding]; other site 204669010839 putative substrate binding site 2 [chemical binding]; other site 204669010840 putative substrate binding site 1 [chemical binding]; other site 204669010841 active site 204669010842 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 204669010843 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 204669010844 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 204669010845 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 204669010846 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 204669010847 Bacterial sugar transferase; Region: Bac_transf; pfam02397 204669010848 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 204669010849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 204669010850 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 204669010851 active site 204669010852 motif I; other site 204669010853 motif II; other site 204669010854 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 204669010855 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 204669010856 putative ribose interaction site [chemical binding]; other site 204669010857 putative ADP binding site [chemical binding]; other site 204669010858 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 204669010859 active site 204669010860 nucleotide binding site [chemical binding]; other site 204669010861 HIGH motif; other site 204669010862 KMSKS motif; other site 204669010863 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 204669010864 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 204669010865 NADP binding site [chemical binding]; other site 204669010866 homopentamer interface [polypeptide binding]; other site 204669010867 substrate binding site [chemical binding]; other site 204669010868 active site 204669010869 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 204669010870 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 204669010871 NADP binding site [chemical binding]; other site 204669010872 active site 204669010873 putative substrate binding site [chemical binding]; other site 204669010874 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 204669010875 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 204669010876 NADP-binding site; other site 204669010877 homotetramer interface [polypeptide binding]; other site 204669010878 substrate binding site [chemical binding]; other site 204669010879 homodimer interface [polypeptide binding]; other site 204669010880 active site 204669010881 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 204669010882 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 204669010883 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 204669010884 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 204669010885 NAD(P) binding site [chemical binding]; other site 204669010886 homodimer interface [polypeptide binding]; other site 204669010887 substrate binding site [chemical binding]; other site 204669010888 active site 204669010889 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 204669010890 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 204669010891 inhibitor-cofactor binding pocket; inhibition site 204669010892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669010893 catalytic residue [active] 204669010894 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 204669010895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 204669010896 motif II; other site 204669010897 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 204669010898 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 204669010899 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 204669010900 Bacterial sugar transferase; Region: Bac_transf; pfam02397 204669010901 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 204669010902 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 204669010903 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 204669010904 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 204669010905 active site 204669010906 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 204669010907 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 204669010908 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 204669010909 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 204669010910 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 204669010911 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 204669010912 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669010913 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 204669010914 Beta-lactamase; Region: Beta-lactamase; pfam00144 204669010915 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669010916 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 204669010917 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 204669010918 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 204669010919 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 204669010920 putative active site [active] 204669010921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669010922 Coenzyme A binding pocket [chemical binding]; other site 204669010923 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 204669010924 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 204669010925 active site 204669010926 octamer interface [polypeptide binding]; other site 204669010927 L-type amino acid transporter; Region: 2A0308; TIGR00911 204669010928 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 204669010929 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 204669010930 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 204669010931 active site 204669010932 putative substrate binding pocket [chemical binding]; other site 204669010933 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669010934 Histidine kinase; Region: His_kinase; pfam06580 204669010935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669010936 ATP binding site [chemical binding]; other site 204669010937 Mg2+ binding site [ion binding]; other site 204669010938 G-X-G motif; other site 204669010939 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 204669010940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669010941 active site 204669010942 phosphorylation site [posttranslational modification] 204669010943 intermolecular recognition site; other site 204669010944 dimerization interface [polypeptide binding]; other site 204669010945 LytTr DNA-binding domain; Region: LytTR; smart00850 204669010946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669010947 TPR motif; other site 204669010948 TPR repeat; Region: TPR_11; pfam13414 204669010949 binding surface 204669010950 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669010951 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669010952 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669010953 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669010954 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669010955 MASE1; Region: MASE1; cl17823 204669010956 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 204669010957 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 204669010958 metal binding site [ion binding]; metal-binding site 204669010959 active site 204669010960 I-site; other site 204669010961 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669010962 HAMP domain; Region: HAMP; pfam00672 204669010963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669010964 dimer interface [polypeptide binding]; other site 204669010965 phosphorylation site [posttranslational modification] 204669010966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669010967 ATP binding site [chemical binding]; other site 204669010968 Mg2+ binding site [ion binding]; other site 204669010969 G-X-G motif; other site 204669010970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669010971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669010972 active site 204669010973 phosphorylation site [posttranslational modification] 204669010974 intermolecular recognition site; other site 204669010975 dimerization interface [polypeptide binding]; other site 204669010976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669010977 DNA binding site [nucleotide binding] 204669010978 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 204669010979 dimer interface [polypeptide binding]; other site 204669010980 Phosphoesterase family; Region: Phosphoesterase; pfam04185 204669010981 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 204669010982 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669010983 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669010984 DNA binding residues [nucleotide binding] 204669010985 Putative zinc-finger; Region: zf-HC2; pfam13490 204669010986 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669010987 binding surface 204669010988 TPR motif; other site 204669010989 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669010990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669010991 TPR motif; other site 204669010992 binding surface 204669010993 ribonuclease III; Reviewed; Region: rnc; PRK00102 204669010994 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 204669010995 dimerization interface [polypeptide binding]; other site 204669010996 active site 204669010997 metal binding site [ion binding]; metal-binding site 204669010998 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 204669010999 dsRNA binding site [nucleotide binding]; other site 204669011000 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 204669011001 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 204669011002 Catalytic site [active] 204669011003 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 204669011004 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 204669011005 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 204669011006 Catalytic site [active] 204669011007 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 204669011008 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 204669011009 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 204669011010 Peptidase family M50; Region: Peptidase_M50; pfam02163 204669011011 active site 204669011012 putative substrate binding region [chemical binding]; other site 204669011013 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 204669011014 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 204669011015 active site 204669011016 HIGH motif; other site 204669011017 dimer interface [polypeptide binding]; other site 204669011018 KMSKS motif; other site 204669011019 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 204669011020 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 204669011021 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 204669011022 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 204669011023 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 204669011024 RNA binding surface [nucleotide binding]; other site 204669011025 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 204669011026 active site 204669011027 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 204669011028 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 204669011029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669011030 homodimer interface [polypeptide binding]; other site 204669011031 catalytic residue [active] 204669011032 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 204669011033 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 204669011034 nucleotide binding site [chemical binding]; other site 204669011035 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14810 204669011036 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 204669011037 DNA binding site [nucleotide binding] 204669011038 catalytic residue [active] 204669011039 H2TH interface [polypeptide binding]; other site 204669011040 putative catalytic residues [active] 204669011041 turnover-facilitating residue; other site 204669011042 intercalation triad [nucleotide binding]; other site 204669011043 8OG recognition residue [nucleotide binding]; other site 204669011044 putative reading head residues; other site 204669011045 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 204669011046 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 204669011047 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 204669011048 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 204669011049 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 204669011050 GDP-binding site [chemical binding]; other site 204669011051 ACT binding site; other site 204669011052 IMP binding site; other site 204669011053 Uncharacterized conserved protein [Function unknown]; Region: COG1359 204669011054 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 204669011055 TPR repeat; Region: TPR_11; pfam13414 204669011056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669011057 binding surface 204669011058 TPR motif; other site 204669011059 TPR repeat; Region: TPR_11; pfam13414 204669011060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 204669011061 TPR motif; other site 204669011062 binding surface 204669011063 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 204669011064 active site 1 [active] 204669011065 dimer interface [polypeptide binding]; other site 204669011066 hexamer interface [polypeptide binding]; other site 204669011067 active site 2 [active] 204669011068 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 204669011069 active site 204669011070 multimer interface [polypeptide binding]; other site 204669011071 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 204669011072 CoA binding domain; Region: CoA_binding; smart00881 204669011073 CoA-ligase; Region: Ligase_CoA; pfam00549 204669011074 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 204669011075 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 204669011076 CoA-ligase; Region: Ligase_CoA; pfam00549 204669011077 Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins; Region: SRPBCC_Aha1; cd08892 204669011078 putative hydrophobic ligand binding site [chemical binding]; other site 204669011079 putative Hsp90 binding residues [polypeptide binding]; other site 204669011080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 204669011081 MOSC domain; Region: MOSC; pfam03473 204669011082 3-alpha domain; Region: 3-alpha; pfam03475 204669011083 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669011084 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 204669011085 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 204669011086 Methyltransferase domain; Region: Methyltransf_24; pfam13578 204669011087 Peptidase family M48; Region: Peptidase_M48; cl12018 204669011088 CHASE2 domain; Region: CHASE2; pfam05226 204669011089 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 204669011090 cyclase homology domain; Region: CHD; cd07302 204669011091 nucleotidyl binding site; other site 204669011092 metal binding site [ion binding]; metal-binding site 204669011093 dimer interface [polypeptide binding]; other site 204669011094 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 204669011095 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 204669011096 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 204669011097 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 204669011098 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 204669011099 substrate binding [chemical binding]; other site 204669011100 active site 204669011101 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 204669011102 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669011103 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669011104 FtsX-like permease family; Region: FtsX; pfam02687 204669011105 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669011106 FtsX-like permease family; Region: FtsX; pfam02687 204669011107 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 204669011108 Penicillinase repressor; Region: Pencillinase_R; pfam03965 204669011109 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 204669011110 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 204669011111 Beta-Casp domain; Region: Beta-Casp; smart01027 204669011112 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 204669011113 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 204669011114 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 204669011115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 204669011116 DNA-binding site [nucleotide binding]; DNA binding site 204669011117 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 204669011118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669011119 homodimer interface [polypeptide binding]; other site 204669011120 catalytic residue [active] 204669011121 Response regulator receiver domain; Region: Response_reg; pfam00072 204669011122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 204669011123 active site 204669011124 phosphorylation site [posttranslational modification] 204669011125 intermolecular recognition site; other site 204669011126 dimerization interface [polypeptide binding]; other site 204669011127 LytTr DNA-binding domain; Region: LytTR; smart00850 204669011128 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669011129 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 204669011130 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 204669011131 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 204669011132 NmrA-like family; Region: NmrA; pfam05368 204669011133 putative NADP binding site [chemical binding]; other site 204669011134 Uncharacterized conserved protein [Function unknown]; Region: COG2128 204669011135 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669011136 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 204669011137 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 204669011138 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 204669011139 putative active site [active] 204669011140 Zn binding site [ion binding]; other site 204669011141 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 204669011142 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 204669011143 active site 204669011144 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 204669011145 Double zinc ribbon; Region: DZR; pfam12773 204669011146 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 204669011147 Sel1-like repeats; Region: SEL1; smart00671 204669011148 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 204669011149 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 204669011150 inhibitor-cofactor binding pocket; inhibition site 204669011151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669011152 catalytic residue [active] 204669011153 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 204669011154 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 204669011155 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 204669011156 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669011157 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 204669011158 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 204669011159 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 204669011160 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 204669011161 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 204669011162 active site 204669011163 catalytic residues [active] 204669011164 metal binding site [ion binding]; metal-binding site 204669011165 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 204669011166 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 204669011167 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 204669011168 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 204669011169 substrate-cofactor binding pocket; other site 204669011170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669011171 catalytic residue [active] 204669011172 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 204669011173 Threonine dehydrogenase; Region: TDH; cd05281 204669011174 structural Zn binding site [ion binding]; other site 204669011175 catalytic Zn binding site [ion binding]; other site 204669011176 tetramer interface [polypeptide binding]; other site 204669011177 NADP binding site [chemical binding]; other site 204669011178 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 204669011179 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 204669011180 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 204669011181 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 204669011182 DNA binding residues [nucleotide binding] 204669011183 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 204669011184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669011185 putative substrate translocation pore; other site 204669011186 BON domain; Region: BON; cl02771 204669011187 BON domain; Region: BON; pfam04972 204669011188 Response regulator receiver domain; Region: Response_reg; pfam00072 204669011189 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 204669011190 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 204669011191 catalytic residues [active] 204669011192 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 204669011193 active site residue [active] 204669011194 putative phosphatase; Provisional; Region: PRK11587 204669011195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 204669011196 active site 204669011197 motif I; other site 204669011198 motif II; other site 204669011199 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 204669011200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669011201 putative substrate translocation pore; other site 204669011202 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 204669011203 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 204669011204 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 204669011205 catalytic residue [active] 204669011206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669011207 Response regulator receiver domain; Region: Response_reg; pfam00072 204669011208 active site 204669011209 phosphorylation site [posttranslational modification] 204669011210 intermolecular recognition site; other site 204669011211 dimerization interface [polypeptide binding]; other site 204669011212 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 204669011213 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 204669011214 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669011215 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669011216 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669011217 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669011218 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669011219 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 204669011220 Asp-box motif; other site 204669011221 catalytic site [active] 204669011222 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 204669011223 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669011224 Catalytic domain of Protein Kinases; Region: PKc; cd00180 204669011225 active site 204669011226 ATP binding site [chemical binding]; other site 204669011227 substrate binding site [chemical binding]; other site 204669011228 activation loop (A-loop); other site 204669011229 Predicted integral membrane protein [Function unknown]; Region: COG5616 204669011230 TPR repeat; Region: TPR_11; pfam13414 204669011231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669011232 binding surface 204669011233 TPR motif; other site 204669011234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669011235 binding surface 204669011236 TPR motif; other site 204669011237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669011238 TPR motif; other site 204669011239 TPR repeat; Region: TPR_11; pfam13414 204669011240 binding surface 204669011241 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 204669011242 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 204669011243 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 204669011244 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 204669011245 Substrate binding site; other site 204669011246 metal-binding site 204669011247 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 204669011248 TPR repeat; Region: TPR_11; pfam13414 204669011249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669011250 binding surface 204669011251 TPR motif; other site 204669011252 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 204669011253 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 204669011254 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 204669011255 Moco binding site; other site 204669011256 metal coordination site [ion binding]; other site 204669011257 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 204669011258 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 204669011259 substrate binding site [chemical binding]; other site 204669011260 oxyanion hole (OAH) forming residues; other site 204669011261 trimer interface [polypeptide binding]; other site 204669011262 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 204669011263 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 204669011264 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 204669011265 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 204669011266 ligand binding site [chemical binding]; other site 204669011267 PhoD-like phosphatase; Region: PhoD; pfam09423 204669011268 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 204669011269 putative active site [active] 204669011270 putative metal binding site [ion binding]; other site 204669011271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 204669011272 dimerization interface [polypeptide binding]; other site 204669011273 putative DNA binding site [nucleotide binding]; other site 204669011274 putative Zn2+ binding site [ion binding]; other site 204669011275 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 204669011276 hydrophobic ligand binding site; other site 204669011277 DinB family; Region: DinB; cl17821 204669011278 DinB superfamily; Region: DinB_2; pfam12867 204669011279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669011280 Coenzyme A binding pocket [chemical binding]; other site 204669011281 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 204669011282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 204669011283 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 204669011284 active site clefts [active] 204669011285 zinc binding site [ion binding]; other site 204669011286 dimer interface [polypeptide binding]; other site 204669011287 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 204669011288 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 204669011289 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 204669011290 catalytic residues [active] 204669011291 catalytic nucleophile [active] 204669011292 Recombinase; Region: Recombinase; pfam07508 204669011293 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 204669011294 oxidative damage protection protein; Provisional; Region: PRK05408 204669011295 ribonuclease R; Region: RNase_R; TIGR02063 204669011296 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 204669011297 RNB domain; Region: RNB; pfam00773 204669011298 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 204669011299 RNA binding site [nucleotide binding]; other site 204669011300 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 204669011301 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 204669011302 inorganic pyrophosphatase; Provisional; Region: PRK02230 204669011303 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 204669011304 dimer interface [polypeptide binding]; other site 204669011305 substrate binding site [chemical binding]; other site 204669011306 metal binding sites [ion binding]; metal-binding site 204669011307 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 204669011308 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 204669011309 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 204669011310 DNA binding residues [nucleotide binding] 204669011311 dimer interface [polypeptide binding]; other site 204669011312 [2Fe-2S] cluster binding site [ion binding]; other site 204669011313 Predicted flavoprotein [General function prediction only]; Region: COG0431 204669011314 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 204669011315 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 204669011316 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 204669011317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669011318 H+ Antiporter protein; Region: 2A0121; TIGR00900 204669011319 putative substrate translocation pore; other site 204669011320 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 204669011321 RNA binding surface [nucleotide binding]; other site 204669011322 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669011323 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669011324 active site 204669011325 ATP binding site [chemical binding]; other site 204669011326 substrate binding site [chemical binding]; other site 204669011327 activation loop (A-loop); other site 204669011328 Predicted integral membrane protein [Function unknown]; Region: COG5616 204669011329 TPR repeat; Region: TPR_11; pfam13414 204669011330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669011331 binding surface 204669011332 TPR motif; other site 204669011333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669011334 TPR motif; other site 204669011335 binding surface 204669011336 DinB superfamily; Region: DinB_2; pfam12867 204669011337 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 204669011338 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 204669011339 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669011340 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 204669011341 active site 204669011342 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 204669011343 motif 1; other site 204669011344 active site 204669011345 motif 2; other site 204669011346 motif 3; other site 204669011347 tRNA synthetases class II (A); Region: tRNA-synt_2c; pfam01411 204669011348 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 204669011349 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 204669011350 DHHA1 domain; Region: DHHA1; pfam02272 204669011351 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 204669011352 hypothetical protein; Reviewed; Region: PRK12497 204669011353 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 204669011354 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 204669011355 RibD C-terminal domain; Region: RibD_C; cl17279 204669011356 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 204669011357 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 204669011358 inhibitor-cofactor binding pocket; inhibition site 204669011359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669011360 catalytic residue [active] 204669011361 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 204669011362 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 204669011363 active site 204669011364 HIGH motif; other site 204669011365 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 204669011366 KMSKS motif; other site 204669011367 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 204669011368 tRNA binding surface [nucleotide binding]; other site 204669011369 anticodon binding site; other site 204669011370 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669011371 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 204669011372 metal ion-dependent adhesion site (MIDAS); other site 204669011373 EamA-like transporter family; Region: EamA; pfam00892 204669011374 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 204669011375 EamA-like transporter family; Region: EamA; pfam00892 204669011376 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 204669011377 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 204669011378 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 204669011379 anti sigma factor interaction site; other site 204669011380 regulatory phosphorylation site [posttranslational modification]; other site 204669011381 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669011382 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 204669011383 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 204669011384 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 204669011385 ligand binding site [chemical binding]; other site 204669011386 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 204669011387 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 204669011388 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 204669011389 PilZ domain; Region: PilZ; pfam07238 204669011390 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 204669011391 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 204669011392 ligand binding site [chemical binding]; other site 204669011393 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 204669011394 Mechanosensitive ion channel; Region: MS_channel; pfam00924 204669011395 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 204669011396 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 204669011397 [2Fe-2S] cluster binding site [ion binding]; other site 204669011398 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 204669011399 putative alpha subunit interface [polypeptide binding]; other site 204669011400 putative active site [active] 204669011401 putative substrate binding site [chemical binding]; other site 204669011402 Fe binding site [ion binding]; other site 204669011403 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 204669011404 FecR protein; Region: FecR; pfam04773 204669011405 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 204669011406 beta-galactosidase; Region: BGL; TIGR03356 204669011407 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 204669011408 active site 204669011409 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 204669011410 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 204669011411 putative active site [active] 204669011412 putative metal binding site [ion binding]; other site 204669011413 Family description; Region: VCBS; pfam13517 204669011414 Family description; Region: VCBS; pfam13517 204669011415 Family description; Region: VCBS; pfam13517 204669011416 Family description; Region: VCBS; pfam13517 204669011417 Family description; Region: VCBS; pfam13517 204669011418 Family description; Region: VCBS; pfam13517 204669011419 CopC domain; Region: CopC; pfam04234 204669011420 Copper resistance protein D; Region: CopD; cl00563 204669011421 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 204669011422 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 204669011423 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669011424 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 204669011425 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 204669011426 Walker A/P-loop; other site 204669011427 ATP binding site [chemical binding]; other site 204669011428 Q-loop/lid; other site 204669011429 ABC transporter signature motif; other site 204669011430 Walker B; other site 204669011431 D-loop; other site 204669011432 H-loop/switch region; other site 204669011433 DevC protein; Region: devC; TIGR01185 204669011434 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669011435 FtsX-like permease family; Region: FtsX; pfam02687 204669011436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 204669011437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 204669011438 WHG domain; Region: WHG; pfam13305 204669011439 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 204669011440 Domain of unknown function DUF20; Region: UPF0118; pfam01594 204669011441 enoyl-CoA hydratase; Provisional; Region: PRK06688 204669011442 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 204669011443 substrate binding site [chemical binding]; other site 204669011444 oxyanion hole (OAH) forming residues; other site 204669011445 trimer interface [polypeptide binding]; other site 204669011446 Domain of unknown function (DUF336); Region: DUF336; cl01249 204669011447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669011448 active site 204669011449 phosphorylation site [posttranslational modification] 204669011450 intermolecular recognition site; other site 204669011451 dimerization interface [polypeptide binding]; other site 204669011452 Escherichia coli YdjC-like family of proteins; Region: YdjC; cd10808 204669011453 putative active site [active] 204669011454 YdjC motif; other site 204669011455 Mg binding site [ion binding]; other site 204669011456 putative homodimer interface [polypeptide binding]; other site 204669011457 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 204669011458 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 204669011459 Histidine kinase; Region: His_kinase; pfam06580 204669011460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669011461 ATP binding site [chemical binding]; other site 204669011462 Mg2+ binding site [ion binding]; other site 204669011463 G-X-G motif; other site 204669011464 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 204669011465 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 204669011466 DHHA1 domain; Region: DHHA1; pfam02272 204669011467 threonine synthase; Validated; Region: PRK08197 204669011468 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 204669011469 homodimer interface [polypeptide binding]; other site 204669011470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669011471 catalytic residue [active] 204669011472 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 204669011473 TPR repeat; Region: TPR_11; pfam13414 204669011474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669011475 binding surface 204669011476 TPR motif; other site 204669011477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 204669011478 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 204669011479 active site 204669011480 motif I; other site 204669011481 motif II; other site 204669011482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 204669011483 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 204669011484 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 204669011485 N-acetyl-D-glucosamine binding site [chemical binding]; other site 204669011486 catalytic residue [active] 204669011487 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 204669011488 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669011489 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 204669011490 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669011491 active site 204669011492 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 204669011493 ATP cone domain; Region: ATP-cone; pfam03477 204669011494 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 204669011495 tartrate dehydrogenase; Region: TTC; TIGR02089 204669011496 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 204669011497 Beta-lactamase; Region: Beta-lactamase; pfam00144 204669011498 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 204669011499 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 204669011500 active site 204669011501 catalytic tetrad [active] 204669011502 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 204669011503 Walker A motif; other site 204669011504 ATP binding site [chemical binding]; other site 204669011505 Walker B motif; other site 204669011506 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 204669011507 DNA Polymerase Y-family; Region: PolY_like; cd03468 204669011508 active site 204669011509 DNA binding site [nucleotide binding] 204669011510 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 204669011511 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 204669011512 active site 204669011513 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 204669011514 generic binding surface II; other site 204669011515 generic binding surface I; other site 204669011516 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 204669011517 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669011518 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669011519 active site 204669011520 ATP binding site [chemical binding]; other site 204669011521 substrate binding site [chemical binding]; other site 204669011522 activation loop (A-loop); other site 204669011523 PilZ domain; Region: PilZ; pfam07238 204669011524 dsRNA-gated channel SID-1; Region: SID-1_RNA_chan; pfam13965 204669011525 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 204669011526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669011527 putative substrate translocation pore; other site 204669011528 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 204669011529 putative acyl-acceptor binding pocket; other site 204669011530 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 204669011531 acyl-activating enzyme (AAE) consensus motif; other site 204669011532 AMP binding site [chemical binding]; other site 204669011533 active site 204669011534 CoA binding site [chemical binding]; other site 204669011535 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 204669011536 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669011537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669011538 active site 204669011539 phosphorylation site [posttranslational modification] 204669011540 intermolecular recognition site; other site 204669011541 dimerization interface [polypeptide binding]; other site 204669011542 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669011543 DNA binding site [nucleotide binding] 204669011544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669011545 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669011546 dimerization interface [polypeptide binding]; other site 204669011547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669011548 dimer interface [polypeptide binding]; other site 204669011549 phosphorylation site [posttranslational modification] 204669011550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669011551 ATP binding site [chemical binding]; other site 204669011552 Mg2+ binding site [ion binding]; other site 204669011553 G-X-G motif; other site 204669011554 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 204669011555 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 204669011556 active site 204669011557 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 204669011558 NlpC/P60 family; Region: NLPC_P60; pfam00877 204669011559 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 204669011560 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 204669011561 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 204669011562 putative active site [active] 204669011563 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 204669011564 GAF domain; Region: GAF_3; pfam13492 204669011565 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 204669011566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 204669011567 putative active site [active] 204669011568 heme pocket [chemical binding]; other site 204669011569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669011570 dimer interface [polypeptide binding]; other site 204669011571 phosphorylation site [posttranslational modification] 204669011572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669011573 ATP binding site [chemical binding]; other site 204669011574 Mg2+ binding site [ion binding]; other site 204669011575 G-X-G motif; other site 204669011576 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 204669011577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669011578 active site 204669011579 phosphorylation site [posttranslational modification] 204669011580 intermolecular recognition site; other site 204669011581 dimerization interface [polypeptide binding]; other site 204669011582 Response regulator receiver domain; Region: Response_reg; pfam00072 204669011583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669011584 active site 204669011585 phosphorylation site [posttranslational modification] 204669011586 intermolecular recognition site; other site 204669011587 dimerization interface [polypeptide binding]; other site 204669011588 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 204669011589 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 204669011590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669011591 active site 204669011592 phosphorylation site [posttranslational modification] 204669011593 intermolecular recognition site; other site 204669011594 dimerization interface [polypeptide binding]; other site 204669011595 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669011596 Zn2+ binding site [ion binding]; other site 204669011597 Mg2+ binding site [ion binding]; other site 204669011598 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 204669011599 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 204669011600 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 204669011601 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669011602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669011603 active site 204669011604 phosphorylation site [posttranslational modification] 204669011605 intermolecular recognition site; other site 204669011606 dimerization interface [polypeptide binding]; other site 204669011607 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 204669011608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669011609 ATP binding site [chemical binding]; other site 204669011610 Mg2+ binding site [ion binding]; other site 204669011611 G-X-G motif; other site 204669011612 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669011613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669011614 active site 204669011615 phosphorylation site [posttranslational modification] 204669011616 intermolecular recognition site; other site 204669011617 dimerization interface [polypeptide binding]; other site 204669011618 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669011619 DNA binding residues [nucleotide binding] 204669011620 dimerization interface [polypeptide binding]; other site 204669011621 BON domain; Region: BON; pfam04972 204669011622 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 204669011623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 204669011624 ATP binding site [chemical binding]; other site 204669011625 Mg2+ binding site [ion binding]; other site 204669011626 G-X-G motif; other site 204669011627 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669011628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669011629 active site 204669011630 phosphorylation site [posttranslational modification] 204669011631 intermolecular recognition site; other site 204669011632 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669011633 DNA binding residues [nucleotide binding] 204669011634 dimerization interface [polypeptide binding]; other site 204669011635 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 204669011636 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 204669011637 nucleophile elbow; other site 204669011638 Surface antigen; Region: Bac_surface_Ag; pfam01103 204669011639 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 204669011640 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 204669011641 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 204669011642 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669011643 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 204669011644 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 204669011645 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 204669011646 Mechanosensitive ion channel; Region: MS_channel; pfam00924 204669011647 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 204669011648 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 204669011649 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 204669011650 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 204669011651 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 204669011652 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 204669011653 active site 204669011654 catalytic site [active] 204669011655 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 204669011656 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669011657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669011658 active site 204669011659 phosphorylation site [posttranslational modification] 204669011660 intermolecular recognition site; other site 204669011661 dimerization interface [polypeptide binding]; other site 204669011662 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 204669011663 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 204669011664 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 204669011665 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 204669011666 putative active site [active] 204669011667 putative metal-binding site [ion binding]; other site 204669011668 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 204669011669 pyruvate kinase; Provisional; Region: PRK05826 204669011670 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 204669011671 domain interfaces; other site 204669011672 active site 204669011673 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 204669011674 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 204669011675 active site 204669011676 ADP/pyrophosphate binding site [chemical binding]; other site 204669011677 dimerization interface [polypeptide binding]; other site 204669011678 allosteric effector site; other site 204669011679 fructose-1,6-bisphosphate binding site; other site 204669011680 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669011681 Catalytic domain of Protein Kinases; Region: PKc; cd00180 204669011682 active site 204669011683 ATP binding site [chemical binding]; other site 204669011684 substrate binding site [chemical binding]; other site 204669011685 activation loop (A-loop); other site 204669011686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669011687 TPR motif; other site 204669011688 binding surface 204669011689 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669011690 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 204669011691 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 204669011692 Family description; Region: VCBS; pfam13517 204669011693 Family description; Region: VCBS; pfam13517 204669011694 Family description; Region: VCBS; pfam13517 204669011695 Family description; Region: VCBS; pfam13517 204669011696 Family description; Region: VCBS; pfam13517 204669011697 Amidinotransferase; Region: Amidinotransf; cl12043 204669011698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669011699 Coenzyme A binding pocket [chemical binding]; other site 204669011700 TraB family; Region: TraB; pfam01963 204669011701 Phosphoesterase family; Region: Phosphoesterase; pfam04185 204669011702 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 204669011703 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 204669011704 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 204669011705 metal binding site 2 [ion binding]; metal-binding site 204669011706 putative DNA binding helix; other site 204669011707 metal binding site 1 [ion binding]; metal-binding site 204669011708 dimer interface [polypeptide binding]; other site 204669011709 structural Zn2+ binding site [ion binding]; other site 204669011710 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 204669011711 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 204669011712 dimer interface [polypeptide binding]; other site 204669011713 decamer (pentamer of dimers) interface [polypeptide binding]; other site 204669011714 catalytic triad [active] 204669011715 peroxidatic and resolving cysteines [active] 204669011716 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 204669011717 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 204669011718 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 204669011719 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 204669011720 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 204669011721 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 204669011722 IHF dimer interface [polypeptide binding]; other site 204669011723 IHF - DNA interface [nucleotide binding]; other site 204669011724 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 204669011725 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 204669011726 tandem repeat interface [polypeptide binding]; other site 204669011727 oligomer interface [polypeptide binding]; other site 204669011728 active site residues [active] 204669011729 PilZ domain; Region: PilZ; pfam07238 204669011730 Fic/DOC family; Region: Fic; cl00960 204669011731 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 204669011732 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 204669011733 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 204669011734 active site 204669011735 catalytic residue [active] 204669011736 dimer interface [polypeptide binding]; other site 204669011737 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 204669011738 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 204669011739 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 204669011740 shikimate binding site; other site 204669011741 NAD(P) binding site [chemical binding]; other site 204669011742 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 204669011743 AMMECR1; Region: AMMECR1; pfam01871 204669011744 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 204669011745 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 204669011746 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 204669011747 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 204669011748 NAD(P) binding site [chemical binding]; other site 204669011749 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 204669011750 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669011751 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669011752 active site 204669011753 ATP binding site [chemical binding]; other site 204669011754 substrate binding site [chemical binding]; other site 204669011755 activation loop (A-loop); other site 204669011756 Predicted integral membrane protein [Function unknown]; Region: COG5616 204669011757 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 204669011758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669011759 binding surface 204669011760 TPR motif; other site 204669011761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669011762 TPR motif; other site 204669011763 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669011764 binding surface 204669011765 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669011766 Catalytic domain of Protein Kinases; Region: PKc; cd00180 204669011767 active site 204669011768 ATP binding site [chemical binding]; other site 204669011769 substrate binding site [chemical binding]; other site 204669011770 activation loop (A-loop); other site 204669011771 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669011772 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 204669011773 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 204669011774 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 204669011775 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 204669011776 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669011777 SnoaL-like domain; Region: SnoaL_2; pfam12680 204669011778 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 204669011779 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 204669011780 glutamine binding [chemical binding]; other site 204669011781 catalytic triad [active] 204669011782 PilZ domain; Region: PilZ; pfam07238 204669011783 Protein of unknown function (DUF419); Region: DUF419; pfam04237 204669011784 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 204669011785 homodimer interface [polypeptide binding]; other site 204669011786 putative active site [active] 204669011787 GAF domain; Region: GAF_3; pfam13492 204669011788 GAF domain; Region: GAF_2; pfam13185 204669011789 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 204669011790 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 204669011791 metal binding site [ion binding]; metal-binding site 204669011792 active site 204669011793 I-site; other site 204669011794 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 204669011795 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669011796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669011797 active site 204669011798 phosphorylation site [posttranslational modification] 204669011799 intermolecular recognition site; other site 204669011800 dimerization interface [polypeptide binding]; other site 204669011801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669011802 Walker A motif; other site 204669011803 ATP binding site [chemical binding]; other site 204669011804 Walker B motif; other site 204669011805 arginine finger; other site 204669011806 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 204669011807 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 204669011808 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 204669011809 Galactose oxidase, central domain; Region: Kelch_3; cl02701 204669011810 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 204669011811 Galactose oxidase, central domain; Region: Kelch_3; cl02701 204669011812 Galactose oxidase, central domain; Region: Kelch_3; cl02701 204669011813 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 204669011814 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 204669011815 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 204669011816 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 204669011817 YtxH-like protein; Region: YtxH; pfam12732 204669011818 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 204669011819 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669011820 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 204669011821 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 204669011822 putative phosphate acyltransferase; Provisional; Region: PRK05331 204669011823 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 204669011824 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 204669011825 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 204669011826 peptide binding site [polypeptide binding]; other site 204669011827 toxin interface [polypeptide binding]; other site 204669011828 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 204669011829 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 204669011830 Zn binding site [ion binding]; other site 204669011831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669011832 non-specific DNA binding site [nucleotide binding]; other site 204669011833 salt bridge; other site 204669011834 sequence-specific DNA binding site [nucleotide binding]; other site 204669011835 dihydroorotase; Validated; Region: pyrC; PRK09357 204669011836 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669011837 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 204669011838 active site 204669011839 Adenylate kinase, active site lid; Region: ADK_lid; pfam05191 204669011840 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 204669011841 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 204669011842 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 204669011843 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 204669011844 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 204669011845 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 204669011846 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669011847 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 204669011848 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669011849 DNA binding site [nucleotide binding] 204669011850 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669011851 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669011852 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 204669011853 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669011854 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669011855 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669011856 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669011857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669011858 Coenzyme A binding pocket [chemical binding]; other site 204669011859 argininosuccinate lyase; Provisional; Region: PRK00855 204669011860 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 204669011861 active sites [active] 204669011862 tetramer interface [polypeptide binding]; other site 204669011863 argininosuccinate synthase; Provisional; Region: PRK13820 204669011864 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 204669011865 ANP binding site [chemical binding]; other site 204669011866 Substrate Binding Site II [chemical binding]; other site 204669011867 Substrate Binding Site I [chemical binding]; other site 204669011868 ornithine carbamoyltransferase; Provisional; Region: PRK00779 204669011869 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 204669011870 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 204669011871 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 204669011872 nucleotide binding site [chemical binding]; other site 204669011873 N-acetyl-L-glutamate binding site [chemical binding]; other site 204669011874 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 204669011875 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 204669011876 Arginine repressor [Transcription]; Region: ArgR; COG1438 204669011877 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 204669011878 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 204669011879 Response regulator receiver domain; Region: Response_reg; pfam00072 204669011880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669011881 active site 204669011882 phosphorylation site [posttranslational modification] 204669011883 intermolecular recognition site; other site 204669011884 dimerization interface [polypeptide binding]; other site 204669011885 homoserine dehydrogenase; Provisional; Region: PRK06270 204669011886 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 204669011887 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 204669011888 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 204669011889 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 204669011890 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 204669011891 catalytic residue [active] 204669011892 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 204669011893 Trp docking motif [polypeptide binding]; other site 204669011894 active site 204669011895 FOG: WD40-like repeat [Function unknown]; Region: COG1520 204669011896 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669011897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669011898 active site 204669011899 phosphorylation site [posttranslational modification] 204669011900 intermolecular recognition site; other site 204669011901 dimerization interface [polypeptide binding]; other site 204669011902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669011903 DNA binding site [nucleotide binding] 204669011904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 204669011905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669011906 dimer interface [polypeptide binding]; other site 204669011907 phosphorylation site [posttranslational modification] 204669011908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669011909 ATP binding site [chemical binding]; other site 204669011910 Mg2+ binding site [ion binding]; other site 204669011911 G-X-G motif; other site 204669011912 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669011913 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 204669011914 dimer interface [polypeptide binding]; other site 204669011915 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 204669011916 Fatty acid desaturase; Region: FA_desaturase; pfam00487 204669011917 Di-iron ligands [ion binding]; other site 204669011918 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 204669011919 DHH family; Region: DHH; pfam01368 204669011920 DHHA1 domain; Region: DHHA1; pfam02272 204669011921 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 204669011922 Protein of unknown function (DUF507); Region: DUF507; cl01112 204669011923 Protein of unknown function (DUF507); Region: DUF507; cl01112 204669011924 PilZ domain; Region: PilZ; pfam07238 204669011925 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 204669011926 GtrA-like protein; Region: GtrA; pfam04138 204669011927 Peptidase family M48; Region: Peptidase_M48; cl12018 204669011928 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 204669011929 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 204669011930 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 204669011931 Phosphoesterase family; Region: Phosphoesterase; pfam04185 204669011932 epoxyqueuosine reductase; Region: TIGR00276 204669011933 e3 binding domain; Region: E3_binding; pfam02817 204669011934 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 204669011935 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 204669011936 DNA-binding site [nucleotide binding]; DNA binding site 204669011937 RNA-binding motif; other site 204669011938 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 204669011939 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 204669011940 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 204669011941 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 204669011942 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 204669011943 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 204669011944 ligand binding site [chemical binding]; other site 204669011945 homodimer interface [polypeptide binding]; other site 204669011946 NAD(P) binding site [chemical binding]; other site 204669011947 trimer interface B [polypeptide binding]; other site 204669011948 trimer interface A [polypeptide binding]; other site 204669011949 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 204669011950 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669011951 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 204669011952 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669011953 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 204669011954 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669011955 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 204669011956 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 204669011957 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 204669011958 Beta-lactamase; Region: Beta-lactamase; pfam00144 204669011959 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 204669011960 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 204669011961 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669011962 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 204669011963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669011964 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669011965 TPR motif; other site 204669011966 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 204669011967 catalytic motif [active] 204669011968 Catalytic residue [active] 204669011969 Aspartyl protease; Region: Asp_protease_2; pfam13650 204669011970 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669011971 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669011972 ligand binding site [chemical binding]; other site 204669011973 flexible hinge region; other site 204669011974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669011975 dimer interface [polypeptide binding]; other site 204669011976 phosphorylation site [posttranslational modification] 204669011977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669011978 ATP binding site [chemical binding]; other site 204669011979 Mg2+ binding site [ion binding]; other site 204669011980 G-X-G motif; other site 204669011981 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 204669011982 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 204669011983 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 204669011984 active site 204669011985 comF family protein; Region: comF; TIGR00201 204669011986 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 204669011987 active site 204669011988 OPT oligopeptide transporter protein; Region: OPT; cl14607 204669011989 putative oligopeptide transporter, OPT family; Region: TIGR00733 204669011990 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 204669011991 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 204669011992 catalytic residue [active] 204669011993 Uncharacterized conserved protein [Function unknown]; Region: COG1872 204669011994 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 204669011995 Na binding site [ion binding]; other site 204669011996 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 204669011997 A new structural DNA glycosylase; Region: AlkD_like; cd06561 204669011998 active site 204669011999 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 204669012000 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 204669012001 active site 204669012002 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 204669012003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669012004 Coenzyme A binding pocket [chemical binding]; other site 204669012005 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 204669012006 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 204669012007 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 204669012008 DHH family; Region: DHH; pfam01368 204669012009 DHHA1 domain; Region: DHHA1; pfam02272 204669012010 Ribosome-binding factor A; Region: RBFA; pfam02033 204669012011 Protein of unknown function (DUF503); Region: DUF503; pfam04456 204669012012 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 204669012013 translation initiation factor IF-2; Region: IF-2; TIGR00487 204669012014 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 204669012015 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 204669012016 G1 box; other site 204669012017 putative GEF interaction site [polypeptide binding]; other site 204669012018 GTP/Mg2+ binding site [chemical binding]; other site 204669012019 Switch I region; other site 204669012020 G2 box; other site 204669012021 G3 box; other site 204669012022 Switch II region; other site 204669012023 G4 box; other site 204669012024 G5 box; other site 204669012025 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 204669012026 Translation-initiation factor 2; Region: IF-2; pfam11987 204669012027 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 204669012028 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 204669012029 NusA N-terminal domain; Region: NusA_N; pfam08529 204669012030 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 204669012031 RNA binding site [nucleotide binding]; other site 204669012032 homodimer interface [polypeptide binding]; other site 204669012033 NusA-like KH domain; Region: KH_5; pfam13184 204669012034 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 204669012035 G-X-X-G motif; other site 204669012036 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 204669012037 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 204669012038 Sm and related proteins; Region: Sm_like; cl00259 204669012039 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 204669012040 putative oligomer interface [polypeptide binding]; other site 204669012041 putative RNA binding site [nucleotide binding]; other site 204669012042 alanine racemase; Reviewed; Region: alr; PRK00053 204669012043 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 204669012044 active site 204669012045 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 204669012046 dimer interface [polypeptide binding]; other site 204669012047 substrate binding site [chemical binding]; other site 204669012048 catalytic residues [active] 204669012049 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 204669012050 putative active site [active] 204669012051 putative catalytic triad [active] 204669012052 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 204669012053 catalytic residues [active] 204669012054 replicative DNA helicase; Region: DnaB; TIGR00665 204669012055 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 204669012056 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 204669012057 Walker A motif; other site 204669012058 ATP binding site [chemical binding]; other site 204669012059 Walker B motif; other site 204669012060 DNA binding loops [nucleotide binding] 204669012061 SurA N-terminal domain; Region: SurA_N; pfam09312 204669012062 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 204669012063 Nudix hydrolase homolog; Region: PLN02791 204669012064 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 204669012065 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 204669012066 putative active site [active] 204669012067 substrate binding site [chemical binding]; other site 204669012068 putative cosubstrate binding site; other site 204669012069 catalytic site [active] 204669012070 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 204669012071 substrate binding site [chemical binding]; other site 204669012072 16S rRNA methyltransferase B; Provisional; Region: PRK14902 204669012073 NusB family; Region: NusB; pfam01029 204669012074 putative RNA binding site [nucleotide binding]; other site 204669012075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669012076 S-adenosylmethionine binding site [chemical binding]; other site 204669012077 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 204669012078 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 204669012079 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 204669012080 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 204669012081 Transglycosylase; Region: Transgly; pfam00912 204669012082 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 204669012083 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 204669012084 C-terminal peptidase (prc); Region: prc; TIGR00225 204669012085 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 204669012086 protein binding site [polypeptide binding]; other site 204669012087 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 204669012088 Catalytic dyad [active] 204669012089 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 204669012090 Sel1-like repeats; Region: SEL1; smart00671 204669012091 Sel1-like repeats; Region: SEL1; smart00671 204669012092 Sel1-like repeats; Region: SEL1; smart00671 204669012093 Sel1-like repeats; Region: SEL1; smart00671 204669012094 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669012095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669012096 DNA binding site [nucleotide binding] 204669012097 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669012098 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669012099 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 204669012100 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669012101 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669012102 active site 204669012103 ATP binding site [chemical binding]; other site 204669012104 substrate binding site [chemical binding]; other site 204669012105 activation loop (A-loop); other site 204669012106 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 204669012107 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669012108 dimerization interface [polypeptide binding]; other site 204669012109 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 204669012110 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 204669012111 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 204669012112 4Fe-4S binding domain; Region: Fer4; cl02805 204669012113 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 204669012114 hydrogenase 2 large subunit; Provisional; Region: PRK10467 204669012115 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 204669012116 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 204669012117 nickel binding site [ion binding]; other site 204669012118 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 204669012119 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 204669012120 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 204669012121 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 204669012122 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 204669012123 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 204669012124 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669012125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669012126 binding surface 204669012127 TPR motif; other site 204669012128 TPR repeat; Region: TPR_11; pfam13414 204669012129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669012130 TPR motif; other site 204669012131 binding surface 204669012132 CHAT domain; Region: CHAT; pfam12770 204669012133 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 204669012134 active site 204669012135 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 204669012136 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 204669012137 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 204669012138 catalytic residues [active] 204669012139 catalytic nucleophile [active] 204669012140 Presynaptic Site I dimer interface [polypeptide binding]; other site 204669012141 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 204669012142 Synaptic Flat tetramer interface [polypeptide binding]; other site 204669012143 Synaptic Site I dimer interface [polypeptide binding]; other site 204669012144 DNA binding site [nucleotide binding] 204669012145 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 204669012146 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 204669012147 TIR domain; Region: TIR_2; pfam13676 204669012148 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 204669012149 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 204669012150 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 204669012151 catalytic residues [active] 204669012152 catalytic nucleophile [active] 204669012153 Presynaptic Site I dimer interface [polypeptide binding]; other site 204669012154 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 204669012155 Synaptic Flat tetramer interface [polypeptide binding]; other site 204669012156 Synaptic Site I dimer interface [polypeptide binding]; other site 204669012157 DNA binding site [nucleotide binding] 204669012158 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 204669012159 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 204669012160 cofactor binding site; other site 204669012161 DNA binding site [nucleotide binding] 204669012162 substrate interaction site [chemical binding]; other site 204669012163 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 204669012164 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 204669012165 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 204669012166 additional DNA contacts [nucleotide binding]; other site 204669012167 mismatch recognition site; other site 204669012168 active site 204669012169 zinc binding site [ion binding]; other site 204669012170 DNA intercalation site [nucleotide binding]; other site 204669012171 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 204669012172 Z1 domain; Region: Z1; pfam10593 204669012173 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 204669012174 AIPR protein; Region: AIPR; pfam10592 204669012175 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 204669012176 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 204669012177 Presynaptic Site I dimer interface [polypeptide binding]; other site 204669012178 catalytic residues [active] 204669012179 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 204669012180 Synaptic Flat tetramer interface [polypeptide binding]; other site 204669012181 Synaptic Site I dimer interface [polypeptide binding]; other site 204669012182 DNA binding site [nucleotide binding] 204669012183 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 204669012184 Transcriptional regulator PadR-like family; Region: PadR; cl17335 204669012185 Helix-turn-helix domain; Region: HTH_17; pfam12728 204669012186 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 204669012187 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 204669012188 active site 204669012189 catalytic residues [active] 204669012190 DNA binding site [nucleotide binding] 204669012191 Int/Topo IB signature motif; other site 204669012192 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 204669012193 Zn binding site [ion binding]; other site 204669012194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669012195 TPR repeat; Region: TPR_11; pfam13414 204669012196 binding surface 204669012197 TPR motif; other site 204669012198 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 204669012199 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 204669012200 Response regulator receiver domain; Region: Response_reg; pfam00072 204669012201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669012202 active site 204669012203 phosphorylation site [posttranslational modification] 204669012204 intermolecular recognition site; other site 204669012205 dimerization interface [polypeptide binding]; other site 204669012206 PilZ domain; Region: PilZ; pfam07238 204669012207 Protein of unknown function DUF262; Region: DUF262; pfam03235 204669012208 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669012209 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669012210 FtsX-like permease family; Region: FtsX; pfam02687 204669012211 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669012212 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 204669012213 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669012214 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 204669012215 active site 204669012216 catalytic residues [active] 204669012217 metal binding site [ion binding]; metal-binding site 204669012218 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 204669012219 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 204669012220 Tetramer interface [polypeptide binding]; other site 204669012221 active site 204669012222 FMN-binding site [chemical binding]; other site 204669012223 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669012224 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 204669012225 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 204669012226 Histidine kinase; Region: HisKA_3; pfam07730 204669012227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669012228 ATP binding site [chemical binding]; other site 204669012229 Mg2+ binding site [ion binding]; other site 204669012230 G-X-G motif; other site 204669012231 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 204669012232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669012233 active site 204669012234 phosphorylation site [posttranslational modification] 204669012235 intermolecular recognition site; other site 204669012236 dimerization interface [polypeptide binding]; other site 204669012237 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 204669012238 DNA binding residues [nucleotide binding] 204669012239 dimerization interface [polypeptide binding]; other site 204669012240 Response regulator receiver domain; Region: Response_reg; pfam00072 204669012241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669012242 active site 204669012243 phosphorylation site [posttranslational modification] 204669012244 intermolecular recognition site; other site 204669012245 dimerization interface [polypeptide binding]; other site 204669012246 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 204669012247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 204669012248 motif II; other site 204669012249 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 204669012250 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 204669012251 generic binding surface I; other site 204669012252 generic binding surface II; other site 204669012253 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669012254 Zn2+ binding site [ion binding]; other site 204669012255 Mg2+ binding site [ion binding]; other site 204669012256 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 204669012257 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 204669012258 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 204669012259 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669012260 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 204669012261 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669012262 DNA binding residues [nucleotide binding] 204669012263 CHC2 zinc finger; Region: zf-CHC2; pfam01807 204669012264 DNA primase; Validated; Region: dnaG; PRK05667 204669012265 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 204669012266 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 204669012267 active site 204669012268 metal binding site [ion binding]; metal-binding site 204669012269 interdomain interaction site; other site 204669012270 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 204669012271 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 204669012272 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 204669012273 FMN binding site [chemical binding]; other site 204669012274 substrate binding site [chemical binding]; other site 204669012275 putative catalytic residue [active] 204669012276 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 204669012277 MutS domain III; Region: MutS_III; pfam05192 204669012278 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669012279 Walker A/P-loop; other site 204669012280 ATP binding site [chemical binding]; other site 204669012281 Q-loop/lid; other site 204669012282 ABC transporter signature motif; other site 204669012283 Walker B; other site 204669012284 D-loop; other site 204669012285 H-loop/switch region; other site 204669012286 Smr domain; Region: Smr; pfam01713 204669012287 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 204669012288 dimer interface [polypeptide binding]; other site 204669012289 active site 204669012290 Schiff base residues; other site 204669012291 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 204669012292 MarR family; Region: MarR_2; pfam12802 204669012293 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669012294 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 204669012295 active site 204669012296 metal binding site [ion binding]; metal-binding site 204669012297 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 204669012298 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 204669012299 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 204669012300 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 204669012301 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 204669012302 glucuronate isomerase; Reviewed; Region: PRK02925 204669012303 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 204669012304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669012305 D-galactonate transporter; Region: 2A0114; TIGR00893 204669012306 putative substrate translocation pore; other site 204669012307 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 204669012308 D-mannonate oxidoreductase; Provisional; Region: PRK08277 204669012309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 204669012310 NAD(P) binding site [chemical binding]; other site 204669012311 active site 204669012312 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 204669012313 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 204669012314 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 204669012315 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 204669012316 YCII-related domain; Region: YCII; cl00999 204669012317 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 204669012318 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669012319 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 204669012320 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 204669012321 homotrimer interaction site [polypeptide binding]; other site 204669012322 putative active site [active] 204669012323 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 204669012324 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669012325 FeS/SAM binding site; other site 204669012326 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 204669012327 quinolinate synthetase; Provisional; Region: PRK09375 204669012328 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 204669012329 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 204669012330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669012331 Walker A/P-loop; other site 204669012332 ATP binding site [chemical binding]; other site 204669012333 Q-loop/lid; other site 204669012334 ABC transporter signature motif; other site 204669012335 Walker B; other site 204669012336 D-loop; other site 204669012337 H-loop/switch region; other site 204669012338 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 204669012339 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 204669012340 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 204669012341 ligand binding site [chemical binding]; other site 204669012342 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 204669012343 hypothetical protein; Provisional; Region: PRK11281 204669012344 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 204669012345 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 204669012346 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 204669012347 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 204669012348 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 204669012349 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 204669012350 phosphopeptide binding site; other site 204669012351 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 204669012352 Protein phosphatase 2C; Region: PP2C; pfam00481 204669012353 active site 204669012354 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 204669012355 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 204669012356 gamma subunit interface [polypeptide binding]; other site 204669012357 epsilon subunit interface [polypeptide binding]; other site 204669012358 LBP interface [polypeptide binding]; other site 204669012359 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 204669012360 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 204669012361 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 204669012362 alpha subunit interaction interface [polypeptide binding]; other site 204669012363 Walker A motif; other site 204669012364 ATP binding site [chemical binding]; other site 204669012365 Walker B motif; other site 204669012366 inhibitor binding site; inhibition site 204669012367 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 204669012368 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 204669012369 core domain interface [polypeptide binding]; other site 204669012370 delta subunit interface [polypeptide binding]; other site 204669012371 epsilon subunit interface [polypeptide binding]; other site 204669012372 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 204669012373 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 204669012374 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 204669012375 beta subunit interaction interface [polypeptide binding]; other site 204669012376 Walker A motif; other site 204669012377 ATP binding site [chemical binding]; other site 204669012378 Walker B motif; other site 204669012379 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 204669012380 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 204669012381 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 204669012382 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 204669012383 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 204669012384 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 204669012385 PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820 204669012386 PA/protease or protease-like domain interface [polypeptide binding]; other site 204669012387 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 204669012388 Peptidase family M28; Region: Peptidase_M28; pfam04389 204669012389 metal binding site [ion binding]; metal-binding site 204669012390 Predicted membrane protein [Function unknown]; Region: COG2855 204669012391 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 204669012392 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 204669012393 HflX GTPase family; Region: HflX; cd01878 204669012394 G1 box; other site 204669012395 GTP/Mg2+ binding site [chemical binding]; other site 204669012396 Switch I region; other site 204669012397 G2 box; other site 204669012398 G3 box; other site 204669012399 Switch II region; other site 204669012400 G4 box; other site 204669012401 G5 box; other site 204669012402 bacterial Hfq-like; Region: Hfq; cd01716 204669012403 hexamer interface [polypeptide binding]; other site 204669012404 Sm1 motif; other site 204669012405 RNA binding site [nucleotide binding]; other site 204669012406 Sm2 motif; other site 204669012407 Protein of unknown function (DUF989); Region: DUF989; pfam06181 204669012408 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 204669012409 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 204669012410 inhibitor-cofactor binding pocket; inhibition site 204669012411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669012412 catalytic residue [active] 204669012413 Cupin domain; Region: Cupin_2; cl17218 204669012414 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 204669012415 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 204669012416 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 204669012417 Bacterial SH3 domain homologues; Region: SH3b; smart00287 204669012418 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669012419 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 204669012420 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 204669012421 E3 interaction surface; other site 204669012422 lipoyl attachment site [posttranslational modification]; other site 204669012423 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 204669012424 E3 interaction surface; other site 204669012425 lipoyl attachment site [posttranslational modification]; other site 204669012426 e3 binding domain; Region: E3_binding; pfam02817 204669012427 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 204669012428 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 204669012429 DNA-binding site [nucleotide binding]; DNA binding site 204669012430 RNA-binding motif; other site 204669012431 Phage-related protein [Function unknown]; Region: COG4695; cl01923 204669012432 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 204669012433 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669012434 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669012435 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 204669012436 four helix bundle protein; Region: TIGR02436 204669012437 large terminase protein; Provisional; Region: 17; PHA02533 204669012438 Terminase-like family; Region: Terminase_6; pfam03237 204669012439 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 204669012440 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 204669012441 active site 204669012442 catalytic residues [active] 204669012443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 204669012444 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 204669012445 Catalytic site [active] 204669012446 PGAP1-like protein; Region: PGAP1; pfam07819 204669012447 Putative serine esterase (DUF676); Region: DUF676; pfam05057 204669012448 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669012449 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 204669012450 FtsX-like permease family; Region: FtsX; pfam02687 204669012451 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669012452 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 204669012453 FtsX-like permease family; Region: FtsX; pfam02687 204669012454 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669012455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669012456 TPR motif; other site 204669012457 binding surface 204669012458 TPR repeat; Region: TPR_11; pfam13414 204669012459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669012460 TPR motif; other site 204669012461 binding surface 204669012462 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669012463 TPR repeat; Region: TPR_11; pfam13414 204669012464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669012465 binding surface 204669012466 TPR motif; other site 204669012467 Tetratricopeptide repeat; Region: TPR_12; pfam13424 204669012468 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 204669012469 Transposase; Region: DEDD_Tnp_IS110; pfam01548 204669012470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 204669012471 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 204669012472 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 204669012473 Right handed beta helix region; Region: Beta_helix; pfam13229 204669012474 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669012475 Transcriptional regulator PadR-like family; Region: PadR; cl17335 204669012476 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669012477 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669012478 active site 204669012479 ATP binding site [chemical binding]; other site 204669012480 substrate binding site [chemical binding]; other site 204669012481 activation loop (A-loop); other site 204669012482 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 204669012483 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669012484 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669012485 active site 204669012486 ATP binding site [chemical binding]; other site 204669012487 substrate binding site [chemical binding]; other site 204669012488 activation loop (A-loop); other site 204669012489 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669012490 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669012491 active site 204669012492 ATP binding site [chemical binding]; other site 204669012493 substrate binding site [chemical binding]; other site 204669012494 activation loop (A-loop); other site 204669012495 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669012496 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669012497 active site 204669012498 ATP binding site [chemical binding]; other site 204669012499 substrate binding site [chemical binding]; other site 204669012500 activation loop (A-loop); other site 204669012501 Predicted integral membrane protein [Function unknown]; Region: COG5616 204669012502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669012503 TPR motif; other site 204669012504 binding surface 204669012505 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669012506 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 204669012507 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669012508 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669012509 FtsX-like permease family; Region: FtsX; pfam02687 204669012510 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669012511 FtsX-like permease family; Region: FtsX; pfam02687 204669012512 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 204669012513 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669012514 active site 204669012515 ATP binding site [chemical binding]; other site 204669012516 substrate binding site [chemical binding]; other site 204669012517 activation loop (A-loop); other site 204669012518 Predicted integral membrane protein [Function unknown]; Region: COG5616 204669012519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669012520 TPR motif; other site 204669012521 TPR repeat; Region: TPR_11; pfam13414 204669012522 binding surface 204669012523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669012524 binding surface 204669012525 TPR motif; other site 204669012526 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 204669012527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669012528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669012529 DNA binding residues [nucleotide binding] 204669012530 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 204669012531 Phosphoesterase family; Region: Phosphoesterase; pfam04185 204669012532 MASE1; Region: MASE1; cl17823 204669012533 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 204669012534 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669012535 Zn2+ binding site [ion binding]; other site 204669012536 Mg2+ binding site [ion binding]; other site 204669012537 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 204669012538 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 204669012539 G1 box; other site 204669012540 putative GEF interaction site [polypeptide binding]; other site 204669012541 GTP/Mg2+ binding site [chemical binding]; other site 204669012542 Switch I region; other site 204669012543 G2 box; other site 204669012544 G3 box; other site 204669012545 Switch II region; other site 204669012546 G4 box; other site 204669012547 G5 box; other site 204669012548 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 204669012549 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 204669012550 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 204669012551 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 204669012552 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 204669012553 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 204669012554 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 204669012555 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 204669012556 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 204669012557 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 204669012558 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 204669012559 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 204669012560 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 204669012561 thiamine phosphate binding site [chemical binding]; other site 204669012562 active site 204669012563 pyrophosphate binding site [ion binding]; other site 204669012564 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 204669012565 Membrane protein of unknown function; Region: DUF360; pfam04020 204669012566 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669012567 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 204669012568 FtsX-like permease family; Region: FtsX; pfam02687 204669012569 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 204669012570 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 204669012571 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 204669012572 protein binding site [polypeptide binding]; other site 204669012573 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 204669012574 active site 204669012575 SUMO-1 interface [polypeptide binding]; other site 204669012576 CAAX protease self-immunity; Region: Abi; pfam02517 204669012577 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 204669012578 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 204669012579 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 204669012580 CoA-binding site [chemical binding]; other site 204669012581 ATP-binding [chemical binding]; other site 204669012582 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 204669012583 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 204669012584 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 204669012585 homodimer interface [polypeptide binding]; other site 204669012586 NADP binding site [chemical binding]; other site 204669012587 substrate binding site [chemical binding]; other site 204669012588 Gram-negative bacterial tonB protein; Region: TonB; cl10048 204669012589 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 204669012590 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669012591 active site 204669012592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 204669012593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 204669012594 WHG domain; Region: WHG; pfam13305 204669012595 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 204669012596 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 204669012597 active site 204669012598 catalytic triad [active] 204669012599 dimer interface [polypeptide binding]; other site 204669012600 PEGA domain; Region: PEGA; pfam08308 204669012601 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669012602 GAF domain; Region: GAF; pfam01590 204669012603 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669012604 Zn2+ binding site [ion binding]; other site 204669012605 Mg2+ binding site [ion binding]; other site 204669012606 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669012607 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 204669012608 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 204669012609 TPR motif; other site 204669012610 binding surface 204669012611 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 204669012612 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 204669012613 putative active site [active] 204669012614 Uncharacterized conserved protein [Function unknown]; Region: COG3391 204669012615 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 204669012616 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 204669012617 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 204669012618 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 204669012619 active site 204669012620 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 204669012621 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 204669012622 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 204669012623 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 204669012624 Hemerythrin; Region: Hemerythrin; cd12107 204669012625 Fe binding site [ion binding]; other site 204669012626 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 204669012627 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 204669012628 Nitrogen regulatory protein P-II; Region: P-II; smart00938 204669012629 ammonium transporter; Region: amt; TIGR00836 204669012630 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 204669012631 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 204669012632 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 204669012633 Putative zinc-finger; Region: zf-HC2; pfam13490 204669012634 Helix-turn-helix domain; Region: HTH_37; pfam13744 204669012635 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 204669012636 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 204669012637 active site 204669012638 metal binding site [ion binding]; metal-binding site 204669012639 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 204669012640 active site 204669012641 metal binding site [ion binding]; metal-binding site 204669012642 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 204669012643 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 204669012644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 204669012645 DinB superfamily; Region: DinB_2; pfam12867 204669012646 DinB family; Region: DinB; cl17821 204669012647 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 204669012648 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669012649 dimer interface [polypeptide binding]; other site 204669012650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669012651 dimer interface [polypeptide binding]; other site 204669012652 phosphorylation site [posttranslational modification] 204669012653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669012654 ATP binding site [chemical binding]; other site 204669012655 Mg2+ binding site [ion binding]; other site 204669012656 G-X-G motif; other site 204669012657 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 204669012658 Catalytic domain of Protein Kinases; Region: PKc; cd00180 204669012659 active site 204669012660 ATP binding site [chemical binding]; other site 204669012661 substrate binding site [chemical binding]; other site 204669012662 activation loop (A-loop); other site 204669012663 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 204669012664 dimer interface [polypeptide binding]; other site 204669012665 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669012666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669012667 active site 204669012668 phosphorylation site [posttranslational modification] 204669012669 intermolecular recognition site; other site 204669012670 dimerization interface [polypeptide binding]; other site 204669012671 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669012672 DNA binding site [nucleotide binding] 204669012673 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669012674 dimerization interface [polypeptide binding]; other site 204669012675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669012676 dimer interface [polypeptide binding]; other site 204669012677 phosphorylation site [posttranslational modification] 204669012678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669012679 ATP binding site [chemical binding]; other site 204669012680 Mg2+ binding site [ion binding]; other site 204669012681 G-X-G motif; other site 204669012682 Transposase IS200 like; Region: Y1_Tnp; cl00848 204669012683 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 204669012684 active site 204669012685 Zn binding site [ion binding]; other site 204669012686 Protein of unknown function (DUF419); Region: DUF419; pfam04237 204669012687 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 204669012688 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 204669012689 purine monophosphate binding site [chemical binding]; other site 204669012690 dimer interface [polypeptide binding]; other site 204669012691 putative catalytic residues [active] 204669012692 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 204669012693 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 204669012694 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 204669012695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669012696 S-adenosylmethionine binding site [chemical binding]; other site 204669012697 peptide chain release factor 1; Validated; Region: prfA; PRK00591 204669012698 This domain is found in peptide chain release factors; Region: PCRF; smart00937 204669012699 RF-1 domain; Region: RF-1; pfam00472 204669012700 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 204669012701 ATP-dependent DNA ligase; Validated; Region: PRK09247 204669012702 Adenylation domain of ATP-dependent DNA Ligases; Region: Adenylation_DNA_ligase; cd07898 204669012703 active site 204669012704 DNA binding site [nucleotide binding] 204669012705 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 204669012706 DNA binding site [nucleotide binding] 204669012707 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 204669012708 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 204669012709 BON domain; Region: BON; pfam04972 204669012710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 204669012711 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 204669012712 putative substrate translocation pore; other site 204669012713 DNA polymerase I; Provisional; Region: PRK05755 204669012714 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 204669012715 active site 204669012716 metal binding site 1 [ion binding]; metal-binding site 204669012717 putative 5' ssDNA interaction site; other site 204669012718 metal binding site 3; metal-binding site 204669012719 metal binding site 2 [ion binding]; metal-binding site 204669012720 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 204669012721 putative DNA binding site [nucleotide binding]; other site 204669012722 putative metal binding site [ion binding]; other site 204669012723 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 204669012724 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 204669012725 active site 204669012726 DNA binding site [nucleotide binding] 204669012727 catalytic site [active] 204669012728 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 204669012729 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 204669012730 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 204669012731 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 204669012732 intersubunit interface [polypeptide binding]; other site 204669012733 active site 204669012734 Zn2+ binding site [ion binding]; other site 204669012735 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669012736 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 204669012737 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 204669012738 N-terminal plug; other site 204669012739 ligand-binding site [chemical binding]; other site 204669012740 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 204669012741 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 204669012742 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 204669012743 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 204669012744 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 204669012745 NIPSNAP; Region: NIPSNAP; pfam07978 204669012746 EamA-like transporter family; Region: EamA; pfam00892 204669012747 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 204669012748 EamA-like transporter family; Region: EamA; pfam00892 204669012749 lipoyl synthase; Provisional; Region: PRK05481 204669012750 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669012751 FeS/SAM binding site; other site 204669012752 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 204669012753 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 204669012754 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 204669012755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669012756 binding surface 204669012757 TPR motif; other site 204669012758 TPR repeat; Region: TPR_11; pfam13414 204669012759 Thymidylate synthase complementing protein; Region: Thy1; cl03630 204669012760 Thymidylate synthase complementing protein; Region: Thy1; cl03630 204669012761 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 204669012762 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 204669012763 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669012764 Protein of unknown function, DUF488; Region: DUF488; cl01246 204669012765 NolX protein; Region: NolX; pfam05819 204669012766 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 204669012767 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 204669012768 dihydropteroate synthase; Region: DHPS; TIGR01496 204669012769 substrate binding pocket [chemical binding]; other site 204669012770 dimer interface [polypeptide binding]; other site 204669012771 inhibitor binding site; inhibition site 204669012772 photolyase PhrII; Region: phr2; TIGR00591 204669012773 DNA photolyase; Region: DNA_photolyase; pfam00875 204669012774 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 204669012775 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 204669012776 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 204669012777 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 204669012778 homodimer interface [polypeptide binding]; other site 204669012779 substrate-cofactor binding pocket; other site 204669012780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669012781 catalytic residue [active] 204669012782 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 204669012783 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669012784 active site 204669012785 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 204669012786 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 204669012787 active site 204669012788 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 204669012789 putative active site [active] 204669012790 dimerization interface [polypeptide binding]; other site 204669012791 putative tRNAtyr binding site [nucleotide binding]; other site 204669012792 FOG: WD40 repeat [General function prediction only]; Region: COG2319 204669012793 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 204669012794 Methyltransferase domain; Region: Methyltransf_31; pfam13847 204669012795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669012796 S-adenosylmethionine binding site [chemical binding]; other site 204669012797 acyl carrier protein; Provisional; Region: acpP; PRK00982 204669012798 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 204669012799 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 204669012800 dimer interface [polypeptide binding]; other site 204669012801 active site 204669012802 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 204669012803 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669012804 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 204669012805 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669012806 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 204669012807 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 204669012808 active site 204669012809 catalytic tetrad [active] 204669012810 Plant mobile domain; Region: PMD; pfam10536 204669012811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669012812 non-specific DNA binding site [nucleotide binding]; other site 204669012813 salt bridge; other site 204669012814 sequence-specific DNA binding site [nucleotide binding]; other site 204669012815 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 204669012816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669012817 Walker A/P-loop; other site 204669012818 ATP binding site [chemical binding]; other site 204669012819 Q-loop/lid; other site 204669012820 ABC transporter signature motif; other site 204669012821 Walker B; other site 204669012822 D-loop; other site 204669012823 H-loop/switch region; other site 204669012824 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 204669012825 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 204669012826 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 204669012827 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 204669012828 putative acyl-acceptor binding pocket; other site 204669012829 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 204669012830 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 204669012831 active site 204669012832 Zn binding site [ion binding]; other site 204669012833 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 204669012834 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 204669012835 active site 204669012836 Zn binding site [ion binding]; other site 204669012837 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 204669012838 mce related protein; Region: MCE; pfam02470 204669012839 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14660 204669012840 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 204669012841 DNA-binding site [nucleotide binding]; DNA binding site 204669012842 RNA-binding motif; other site 204669012843 Protein of unknown function, DUF488; Region: DUF488; pfam04343 204669012844 selenocysteine synthase; Provisional; Region: PRK04311 204669012845 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 204669012846 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 204669012847 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 204669012848 catalytic residue [active] 204669012849 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 204669012850 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 204669012851 ssDNA binding site; other site 204669012852 generic binding surface II; other site 204669012853 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 204669012854 ATP binding site [chemical binding]; other site 204669012855 putative Mg++ binding site [ion binding]; other site 204669012856 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 204669012857 nucleotide binding region [chemical binding]; other site 204669012858 ATP-binding site [chemical binding]; other site 204669012859 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669012860 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 204669012861 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 204669012862 GAF domain; Region: GAF_3; pfam13492 204669012863 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 204669012864 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 204669012865 metal binding site [ion binding]; metal-binding site 204669012866 active site 204669012867 I-site; other site 204669012868 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 204669012869 protein binding site [polypeptide binding]; other site 204669012870 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 204669012871 protein binding site [polypeptide binding]; other site 204669012872 Pleckstrin homology-like domain; Region: PH-like; cl17171 204669012873 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 204669012874 Putative zinc-finger; Region: zf-HC2; pfam13490 204669012875 HEAT repeats; Region: HEAT_2; pfam13646 204669012876 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 204669012877 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669012878 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669012879 DNA binding residues [nucleotide binding] 204669012880 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669012881 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669012882 FtsX-like permease family; Region: FtsX; pfam02687 204669012883 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669012884 FtsX-like permease family; Region: FtsX; pfam02687 204669012885 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 204669012886 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 204669012887 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 204669012888 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 204669012889 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 204669012890 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 204669012891 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 204669012892 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 204669012893 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 204669012894 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 204669012895 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 204669012896 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 204669012897 putative active site [active] 204669012898 catalytic residue [active] 204669012899 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 204669012900 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 204669012901 5S rRNA interface [nucleotide binding]; other site 204669012902 CTC domain interface [polypeptide binding]; other site 204669012903 L16 interface [polypeptide binding]; other site 204669012904 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 204669012905 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 204669012906 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 204669012907 active site 204669012908 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 204669012909 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 204669012910 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 204669012911 active site 204669012912 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 204669012913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669012914 Walker A motif; other site 204669012915 ATP binding site [chemical binding]; other site 204669012916 Walker B motif; other site 204669012917 arginine finger; other site 204669012918 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 204669012919 DinB family; Region: DinB; cl17821 204669012920 Predicted transcriptional regulator [Transcription]; Region: COG2378 204669012921 HTH domain; Region: HTH_11; pfam08279 204669012922 WYL domain; Region: WYL; pfam13280 204669012923 DinB family; Region: DinB; cl17821 204669012924 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 204669012925 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 204669012926 inhibitor-cofactor binding pocket; inhibition site 204669012927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 204669012928 catalytic residue [active] 204669012929 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 204669012930 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 204669012931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 204669012932 ATP binding site [chemical binding]; other site 204669012933 putative Mg++ binding site [ion binding]; other site 204669012934 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 204669012935 nucleotide binding region [chemical binding]; other site 204669012936 ATP-binding site [chemical binding]; other site 204669012937 TRCF domain; Region: TRCF; pfam03461 204669012938 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 204669012939 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 204669012940 active site 204669012941 tetramer interface; other site 204669012942 AIR carboxylase; Region: AIRC; pfam00731 204669012943 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 204669012944 TonB C terminal; Region: TonB_2; pfam13103 204669012945 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 204669012946 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 204669012947 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669012948 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669012949 DNA binding site [nucleotide binding] 204669012950 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 204669012951 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 204669012952 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 204669012953 dimerization interface [polypeptide binding]; other site 204669012954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 204669012955 dimer interface [polypeptide binding]; other site 204669012956 phosphorylation site [posttranslational modification] 204669012957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669012958 ATP binding site [chemical binding]; other site 204669012959 Mg2+ binding site [ion binding]; other site 204669012960 G-X-G motif; other site 204669012961 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 204669012962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669012963 active site 204669012964 phosphorylation site [posttranslational modification] 204669012965 intermolecular recognition site; other site 204669012966 dimerization interface [polypeptide binding]; other site 204669012967 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 204669012968 DNA binding site [nucleotide binding] 204669012969 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 204669012970 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 204669012971 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 204669012972 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 204669012973 S-adenosylmethionine synthetase; Validated; Region: PRK05250 204669012974 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 204669012975 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 204669012976 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 204669012977 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 204669012978 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 204669012979 active site 204669012980 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 204669012981 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 204669012982 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 204669012983 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 204669012984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 204669012985 non-specific DNA binding site [nucleotide binding]; other site 204669012986 salt bridge; other site 204669012987 sequence-specific DNA binding site [nucleotide binding]; other site 204669012988 HipA N-terminal domain; Region: Couple_hipA; pfam13657 204669012989 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 204669012990 HipA-like N-terminal domain; Region: HipA_N; pfam07805 204669012991 HipA-like C-terminal domain; Region: HipA_C; pfam07804 204669012992 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669012993 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669012994 FtsX-like permease family; Region: FtsX; pfam02687 204669012995 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669012996 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 204669012997 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 204669012998 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 204669012999 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 204669013000 ABC-2 type transporter; Region: ABC2_membrane; cl17235 204669013001 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 204669013002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669013003 Walker A/P-loop; other site 204669013004 ATP binding site [chemical binding]; other site 204669013005 Q-loop/lid; other site 204669013006 ABC transporter signature motif; other site 204669013007 Walker B; other site 204669013008 D-loop; other site 204669013009 H-loop/switch region; other site 204669013010 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 204669013011 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 204669013012 HlyD family secretion protein; Region: HlyD_3; pfam13437 204669013013 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 204669013014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 204669013015 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 204669013016 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 204669013017 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 204669013018 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 204669013019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 204669013020 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 204669013021 putative dimerization interface [polypeptide binding]; other site 204669013022 putative substrate binding pocket [chemical binding]; other site 204669013023 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 204669013024 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 204669013025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 204669013026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 204669013027 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 204669013028 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 204669013029 putative NAD(P) binding site [chemical binding]; other site 204669013030 active site 204669013031 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 204669013032 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 204669013033 putative NAD(P) binding site [chemical binding]; other site 204669013034 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 204669013035 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 204669013036 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 204669013037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669013038 Walker A/P-loop; other site 204669013039 ATP binding site [chemical binding]; other site 204669013040 Q-loop/lid; other site 204669013041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 204669013042 ABC transporter signature motif; other site 204669013043 Walker B; other site 204669013044 D-loop; other site 204669013045 ABC transporter; Region: ABC_tran_2; pfam12848 204669013046 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 204669013047 Uncharacterized conserved protein [Function unknown]; Region: COG2353 204669013048 Pirin-related protein [General function prediction only]; Region: COG1741 204669013049 Pirin; Region: Pirin; pfam02678 204669013050 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 204669013051 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 204669013052 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 204669013053 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 204669013054 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 204669013055 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 204669013056 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 204669013057 aspartate racemase; Region: asp_race; TIGR00035 204669013058 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 204669013059 putative hydrophobic ligand binding site [chemical binding]; other site 204669013060 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 204669013061 dimerization interface [polypeptide binding]; other site 204669013062 putative DNA binding site [nucleotide binding]; other site 204669013063 putative Zn2+ binding site [ion binding]; other site 204669013064 Arginase family; Region: Arginase; cd09989 204669013065 agmatinase; Region: agmatinase; TIGR01230 204669013066 active site 204669013067 Mn binding site [ion binding]; other site 204669013068 oligomer interface [polypeptide binding]; other site 204669013069 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 204669013070 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 204669013071 putative dimer interface [polypeptide binding]; other site 204669013072 putative anticodon binding site; other site 204669013073 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 204669013074 homodimer interface [polypeptide binding]; other site 204669013075 motif 1; other site 204669013076 motif 2; other site 204669013077 active site 204669013078 motif 3; other site 204669013079 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 204669013080 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 204669013081 Metal-binding active site; metal-binding site 204669013082 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 204669013083 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 204669013084 hypothetical protein; Provisional; Region: PRK07906 204669013085 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 204669013086 putative metal binding site [ion binding]; other site 204669013087 TPR repeat; Region: TPR_11; pfam13414 204669013088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013089 TPR motif; other site 204669013090 binding surface 204669013091 TPR repeat; Region: TPR_11; pfam13414 204669013092 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 204669013093 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 204669013094 Zn2+ binding site [ion binding]; other site 204669013095 Mg2+ binding site [ion binding]; other site 204669013096 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 204669013097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013098 binding surface 204669013099 Tetratricopeptide repeat; Region: TPR_16; pfam13432 204669013100 TPR motif; other site 204669013101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013102 binding surface 204669013103 TPR motif; other site 204669013104 TPR repeat; Region: TPR_11; pfam13414 204669013105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013106 binding surface 204669013107 TPR motif; other site 204669013108 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 204669013109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013110 binding surface 204669013111 TPR motif; other site 204669013112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013113 binding surface 204669013114 TPR motif; other site 204669013115 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 204669013116 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 204669013117 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 204669013118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013119 binding surface 204669013120 TPR motif; other site 204669013121 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 204669013122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013123 TPR motif; other site 204669013124 binding surface 204669013125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013126 TPR motif; other site 204669013127 binding surface 204669013128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013129 binding surface 204669013130 TPR motif; other site 204669013131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013132 binding surface 204669013133 TPR motif; other site 204669013134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013135 binding surface 204669013136 TPR motif; other site 204669013137 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013138 binding surface 204669013139 TPR motif; other site 204669013140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013141 binding surface 204669013142 TPR motif; other site 204669013143 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 204669013144 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 204669013145 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 204669013146 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 204669013147 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 204669013148 anti sigma factor interaction site; other site 204669013149 regulatory phosphorylation site [posttranslational modification]; other site 204669013150 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 204669013151 thymidylate kinase; Region: DTMP_kinase; TIGR00041 204669013152 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 204669013153 active site 204669013154 Predicted metalloprotease [General function prediction only]; Region: COG2321 204669013155 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 204669013156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 204669013157 ATP binding site [chemical binding]; other site 204669013158 Mg2+ binding site [ion binding]; other site 204669013159 G-X-G motif; other site 204669013160 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 204669013161 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 204669013162 Metal-binding active site; metal-binding site 204669013163 amidophosphoribosyltransferase; Provisional; Region: PRK09123 204669013164 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 204669013165 active site 204669013166 tetramer interface [polypeptide binding]; other site 204669013167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 204669013168 active site 204669013169 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 204669013170 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 204669013171 dimerization interface [polypeptide binding]; other site 204669013172 ATP binding site [chemical binding]; other site 204669013173 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 204669013174 dimerization interface [polypeptide binding]; other site 204669013175 ATP binding site [chemical binding]; other site 204669013176 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 204669013177 PemK-like protein; Region: PemK; cl00995 204669013178 Predicted transcriptional regulators [Transcription]; Region: COG1695 204669013179 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 204669013180 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 204669013181 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669013182 FtsX-like permease family; Region: FtsX; pfam02687 204669013183 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669013184 FtsX-like permease family; Region: FtsX; pfam02687 204669013185 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 204669013186 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 204669013187 G1 box; other site 204669013188 putative GEF interaction site [polypeptide binding]; other site 204669013189 GTP/Mg2+ binding site [chemical binding]; other site 204669013190 Switch I region; other site 204669013191 G2 box; other site 204669013192 G3 box; other site 204669013193 Switch II region; other site 204669013194 G4 box; other site 204669013195 G5 box; other site 204669013196 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 204669013197 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 204669013198 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 204669013199 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 204669013200 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 204669013201 Glucose inhibited division protein A; Region: GIDA; pfam01134 204669013202 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669013203 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 204669013204 FtsX-like permease family; Region: FtsX; pfam02687 204669013205 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 204669013206 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 204669013207 FtsX-like permease family; Region: FtsX; pfam02687 204669013208 GTP-binding protein Der; Reviewed; Region: PRK00093 204669013209 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 204669013210 G1 box; other site 204669013211 GTP/Mg2+ binding site [chemical binding]; other site 204669013212 Switch I region; other site 204669013213 G2 box; other site 204669013214 Switch II region; other site 204669013215 G3 box; other site 204669013216 G4 box; other site 204669013217 G5 box; other site 204669013218 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 204669013219 G1 box; other site 204669013220 GTP/Mg2+ binding site [chemical binding]; other site 204669013221 Switch I region; other site 204669013222 G2 box; other site 204669013223 G3 box; other site 204669013224 Switch II region; other site 204669013225 G4 box; other site 204669013226 G5 box; other site 204669013227 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 204669013228 DEAD/DEAH box helicase; Region: DEAD; pfam00270 204669013229 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 204669013230 Predicted membrane protein [Function unknown]; Region: COG3918 204669013231 putative acetyltransferase; Provisional; Region: PRK03624 204669013232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 204669013233 Coenzyme A binding pocket [chemical binding]; other site 204669013234 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 204669013235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 204669013236 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 204669013237 dimerization interface [polypeptide binding]; other site 204669013238 substrate binding pocket [chemical binding]; other site 204669013239 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 204669013240 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 204669013241 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 204669013242 Domain of unknown function (DUF309); Region: DUF309; pfam03745 204669013243 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 204669013244 active site 204669013245 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 204669013246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 204669013247 FeS/SAM binding site; other site 204669013248 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 204669013249 Ligand Binding Site [chemical binding]; other site 204669013250 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669013251 TPR repeat; Region: TPR_11; pfam13414 204669013252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013253 binding surface 204669013254 TPR motif; other site 204669013255 TPR repeat; Region: TPR_11; pfam13414 204669013256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013257 binding surface 204669013258 TPR motif; other site 204669013259 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 204669013260 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 204669013261 dimer interface [polypeptide binding]; other site 204669013262 putative functional site; other site 204669013263 putative MPT binding site; other site 204669013264 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 204669013265 trimer interface [polypeptide binding]; other site 204669013266 dimer interface [polypeptide binding]; other site 204669013267 putative active site [active] 204669013268 Response regulator receiver domain; Region: Response_reg; pfam00072 204669013269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669013270 active site 204669013271 phosphorylation site [posttranslational modification] 204669013272 intermolecular recognition site; other site 204669013273 dimerization interface [polypeptide binding]; other site 204669013274 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 204669013275 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 204669013276 MPT binding site; other site 204669013277 trimer interface [polypeptide binding]; other site 204669013278 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 204669013279 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 204669013280 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 204669013281 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 204669013282 Response regulator receiver domain; Region: Response_reg; pfam00072 204669013283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 204669013284 active site 204669013285 phosphorylation site [posttranslational modification] 204669013286 intermolecular recognition site; other site 204669013287 dimerization interface [polypeptide binding]; other site 204669013288 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 204669013289 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 204669013290 nucleotide binding pocket [chemical binding]; other site 204669013291 K-X-D-G motif; other site 204669013292 catalytic site [active] 204669013293 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 204669013294 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 204669013295 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 204669013296 Dimer interface [polypeptide binding]; other site 204669013297 BRCT sequence motif; other site 204669013298 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 204669013299 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 204669013300 PRC-barrel domain; Region: PRC; pfam05239 204669013301 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 204669013302 nucleotide binding site/active site [active] 204669013303 HIT family signature motif; other site 204669013304 catalytic residue [active] 204669013305 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 204669013306 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 204669013307 RNA binding site [nucleotide binding]; other site 204669013308 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 204669013309 RNA binding site [nucleotide binding]; other site 204669013310 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 204669013311 RNA binding site [nucleotide binding]; other site 204669013312 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 204669013313 RNA binding site [nucleotide binding]; other site 204669013314 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 204669013315 RNA binding site [nucleotide binding]; other site 204669013316 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 204669013317 RNA binding site [nucleotide binding]; other site 204669013318 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669013319 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 204669013320 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 204669013321 Peptidase family M28; Region: Peptidase_M28; pfam04389 204669013322 putative metal binding site [ion binding]; other site 204669013323 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 204669013324 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 204669013325 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 204669013326 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 204669013327 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 204669013328 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 204669013329 active site 1 [active] 204669013330 dimer interface [polypeptide binding]; other site 204669013331 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 204669013332 hexamer interface [polypeptide binding]; other site 204669013333 active site 2 [active] 204669013334 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 204669013335 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 204669013336 domain interfaces; other site 204669013337 active site 204669013338 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 204669013339 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 204669013340 homodimer interaction site [polypeptide binding]; other site 204669013341 cofactor binding site; other site 204669013342 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 204669013343 putative active site [active] 204669013344 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 204669013345 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 204669013346 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 204669013347 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 204669013348 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 204669013349 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 204669013350 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 204669013351 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 204669013352 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 204669013353 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 204669013354 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 204669013355 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 204669013356 DNA binding site [nucleotide binding] 204669013357 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 204669013358 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 204669013359 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 204669013360 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 204669013361 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 204669013362 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 204669013363 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 204669013364 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 204669013365 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 204669013366 RPB3 interaction site [polypeptide binding]; other site 204669013367 RPB1 interaction site [polypeptide binding]; other site 204669013368 RPB11 interaction site [polypeptide binding]; other site 204669013369 RPB10 interaction site [polypeptide binding]; other site 204669013370 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 204669013371 core dimer interface [polypeptide binding]; other site 204669013372 peripheral dimer interface [polypeptide binding]; other site 204669013373 L10 interface [polypeptide binding]; other site 204669013374 L11 interface [polypeptide binding]; other site 204669013375 putative EF-Tu interaction site [polypeptide binding]; other site 204669013376 putative EF-G interaction site [polypeptide binding]; other site 204669013377 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 204669013378 23S rRNA interface [nucleotide binding]; other site 204669013379 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 204669013380 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 204669013381 mRNA/rRNA interface [nucleotide binding]; other site 204669013382 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 204669013383 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 204669013384 23S rRNA interface [nucleotide binding]; other site 204669013385 L7/L12 interface [polypeptide binding]; other site 204669013386 putative thiostrepton binding site; other site 204669013387 L25 interface [polypeptide binding]; other site 204669013388 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 204669013389 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 204669013390 putative homodimer interface [polypeptide binding]; other site 204669013391 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 204669013392 heterodimer interface [polypeptide binding]; other site 204669013393 homodimer interface [polypeptide binding]; other site 204669013394 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 204669013395 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 204669013396 elongation factor Tu; Reviewed; Region: PRK00049 204669013397 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 204669013398 G1 box; other site 204669013399 GEF interaction site [polypeptide binding]; other site 204669013400 GTP/Mg2+ binding site [chemical binding]; other site 204669013401 Switch I region; other site 204669013402 G2 box; other site 204669013403 G3 box; other site 204669013404 Switch II region; other site 204669013405 G4 box; other site 204669013406 G5 box; other site 204669013407 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 204669013408 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 204669013409 Antibiotic Binding Site [chemical binding]; other site 204669013410 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 204669013411 Putative zinc-finger; Region: zf-HC2; pfam13490 204669013412 RNA polymerase sigma factor; Provisional; Region: PRK11924 204669013413 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 204669013414 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 204669013415 DNA binding residues [nucleotide binding] 204669013416 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 204669013417 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 204669013418 active site 204669013419 metal binding site [ion binding]; metal-binding site 204669013420 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 204669013421 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 204669013422 Tropomyosin like; Region: Tropomyosin_1; pfam12718 204669013423 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 204669013424 Peptidase family M23; Region: Peptidase_M23; pfam01551 204669013425 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 204669013426 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 204669013427 active site 204669013428 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 204669013429 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 204669013430 thiamine monophosphate kinase; Provisional; Region: PRK05731 204669013431 ATP binding site [chemical binding]; other site 204669013432 dimerization interface [polypeptide binding]; other site 204669013433 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 204669013434 PLD-like domain; Region: PLDc_2; pfam13091 204669013435 putative active site [active] 204669013436 catalytic site [active] 204669013437 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 204669013438 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 204669013439 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 204669013440 Uncharacterized conserved protein [Function unknown]; Region: COG4095 204669013441 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 204669013442 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 204669013443 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 204669013444 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 204669013445 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 204669013446 homodimer interface [polypeptide binding]; other site 204669013447 Walker A motif; other site 204669013448 ATP binding site [chemical binding]; other site 204669013449 hydroxycobalamin binding site [chemical binding]; other site 204669013450 Walker B motif; other site 204669013451 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 204669013452 DinB superfamily; Region: DinB_2; pfam12867 204669013453 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 204669013454 IHF dimer interface [polypeptide binding]; other site 204669013455 IHF - DNA interface [nucleotide binding]; other site 204669013456 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 204669013457 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 204669013458 active site 204669013459 catalytic site [active] 204669013460 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 204669013461 isocitrate lyase; Provisional; Region: PRK15063 204669013462 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 204669013463 tetramer interface [polypeptide binding]; other site 204669013464 active site 204669013465 Mg2+/Mn2+ binding site [ion binding]; other site 204669013466 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 204669013467 malate synthase A; Region: malate_syn_A; TIGR01344 204669013468 active site 204669013469 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 204669013470 intersubunit interface [polypeptide binding]; other site 204669013471 active site 204669013472 Zn2+ binding site [ion binding]; other site 204669013473 Family description; Region: VCBS; pfam13517 204669013474 Family description; Region: VCBS; pfam13517 204669013475 Family description; Region: VCBS; pfam13517 204669013476 Family description; Region: VCBS; pfam13517 204669013477 Family description; Region: VCBS; pfam13517 204669013478 Family description; Region: VCBS; pfam13517 204669013479 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 204669013480 active site 204669013481 DNA binding site [nucleotide binding] 204669013482 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 204669013483 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 204669013484 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 204669013485 GatB domain; Region: GatB_Yqey; smart00845 204669013486 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 204669013487 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 204669013488 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 204669013489 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 204669013490 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 204669013491 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 204669013492 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 204669013493 putative active site [active] 204669013494 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 204669013495 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 204669013496 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 204669013497 RuvA N terminal domain; Region: RuvA_N; pfam01330 204669013498 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 204669013499 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 204669013500 SEC-C motif; Region: SEC-C; pfam02810 204669013501 TPR repeat; Region: TPR_11; pfam13414 204669013502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013503 binding surface 204669013504 TPR motif; other site 204669013505 TPR repeat; Region: TPR_11; pfam13414 204669013506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013507 binding surface 204669013508 TPR motif; other site 204669013509 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 204669013510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 204669013511 binding surface 204669013512 TPR motif; other site 204669013513 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 204669013514 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 204669013515 trmE is a tRNA modification GTPase; Region: trmE; cd04164 204669013516 G1 box; other site 204669013517 GTP/Mg2+ binding site [chemical binding]; other site 204669013518 Switch I region; other site 204669013519 G2 box; other site 204669013520 Switch II region; other site 204669013521 G3 box; other site 204669013522 G4 box; other site 204669013523 G5 box; other site 204669013524 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 204669013525 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 204669013526 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 204669013527 ligand binding site [chemical binding]; other site 204669013528 flexible hinge region; other site 204669013529 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 204669013530 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 204669013531 FOG: CBS domain [General function prediction only]; Region: COG0517 204669013532 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 204669013533 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 204669013534 Walker A/P-loop; other site 204669013535 ATP binding site [chemical binding]; other site 204669013536 Q-loop/lid; other site 204669013537 ABC transporter signature motif; other site 204669013538 Walker B; other site 204669013539 D-loop; other site 204669013540 H-loop/switch region; other site 204669013541 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 204669013542 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 204669013543 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 204669013544 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 204669013545 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 204669013546 active site 204669013547 dimer interface [polypeptide binding]; other site 204669013548 motif 1; other site 204669013549 motif 2; other site 204669013550 motif 3; other site 204669013551 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 204669013552 anticodon binding site; other site 204669013553 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 204669013554 dimer interface [polypeptide binding]; other site 204669013555 ADP-ribose binding site [chemical binding]; other site 204669013556 active site 204669013557 nudix motif; other site 204669013558 metal binding site [ion binding]; metal-binding site 204669013559 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 204669013560 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 204669013561 Sulfate transporter family; Region: Sulfate_transp; pfam00916 204669013562 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 204669013563 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 204669013564 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 204669013565 active site 204669013566 Methyltransferase domain; Region: Methyltransf_23; pfam13489 204669013567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669013568 S-adenosylmethionine binding site [chemical binding]; other site 204669013569 pantoate--beta-alanine ligase; Region: panC; TIGR00018 204669013570 Pantoate-beta-alanine ligase; Region: PanC; cd00560 204669013571 active site 204669013572 ATP-binding site [chemical binding]; other site 204669013573 pantoate-binding site; other site 204669013574 HXXH motif; other site 204669013575 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 204669013576 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 204669013577 active site 204669013578 metal binding site [ion binding]; metal-binding site 204669013579 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 204669013580 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 204669013581 oligomerization interface [polypeptide binding]; other site 204669013582 active site 204669013583 metal binding site [ion binding]; metal-binding site 204669013584 Beta-propeller repeat; Region: SBBP; pfam06739 204669013585 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 204669013586 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 204669013587 Substrate-binding site [chemical binding]; other site 204669013588 Substrate specificity [chemical binding]; other site 204669013589 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 204669013590 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 204669013591 NodB motif; other site 204669013592 active site 204669013593 catalytic site [active] 204669013594 metal binding site [ion binding]; metal-binding site 204669013595 Isochorismatase family; Region: Isochorismatase; pfam00857 204669013596 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 204669013597 catalytic triad [active] 204669013598 conserved cis-peptide bond; other site 204669013599 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 204669013600 elongation factor G; Reviewed; Region: PRK12740 204669013601 G1 box; other site 204669013602 putative GEF interaction site [polypeptide binding]; other site 204669013603 GTP/Mg2+ binding site [chemical binding]; other site 204669013604 Switch I region; other site 204669013605 G2 box; other site 204669013606 G3 box; other site 204669013607 Switch II region; other site 204669013608 G4 box; other site 204669013609 G5 box; other site 204669013610 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 204669013611 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 204669013612 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 204669013613 Thioredoxin; Region: Thioredoxin_4; cl17273 204669013614 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 204669013615 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 204669013616 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 204669013617 active site 204669013618 catalytic tetrad [active] 204669013619 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 204669013620 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 204669013621 protease TldD; Provisional; Region: tldD; PRK10735 204669013622 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 204669013623 putative amphipathic alpha helix; other site 204669013624 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 204669013625 Clp amino terminal domain; Region: Clp_N; pfam02861 204669013626 Clp amino terminal domain; Region: Clp_N; pfam02861 204669013627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669013628 Walker A motif; other site 204669013629 ATP binding site [chemical binding]; other site 204669013630 Walker B motif; other site 204669013631 arginine finger; other site 204669013632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 204669013633 Walker A motif; other site 204669013634 ATP binding site [chemical binding]; other site 204669013635 Walker B motif; other site 204669013636 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 204669013637 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 204669013638 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 204669013639 putative dimer interface [polypeptide binding]; other site 204669013640 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 204669013641 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 204669013642 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 204669013643 putative RNA binding site [nucleotide binding]; other site 204669013644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 204669013645 S-adenosylmethionine binding site [chemical binding]; other site 204669013646 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 204669013647 Putative zinc ribbon domain; Region: DUF164; pfam02591 204669013648 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 204669013649 DNA gyrase subunit A; Validated; Region: PRK05560 204669013650 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 204669013651 CAP-like domain; other site 204669013652 active site 204669013653 primary dimer interface [polypeptide binding]; other site 204669013654 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 204669013655 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 204669013656 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 204669013657 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 204669013658 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 204669013659 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 204669013660 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 204669013661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669013662 ABC transporter signature motif; other site 204669013663 Walker B; other site 204669013664 D-loop; other site 204669013665 H-loop/switch region; other site 204669013666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 204669013667 Walker A/P-loop; other site 204669013668 ATP binding site [chemical binding]; other site 204669013669 Q-loop/lid; other site 204669013670 ABC transporter signature motif; other site 204669013671 Walker B; other site 204669013672 D-loop; other site 204669013673 H-loop/switch region; other site 204669013674 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 204669013675 anti sigma factor interaction site; other site 204669013676 regulatory phosphorylation site [posttranslational modification]; other site 204669013677 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 204669013678 PQQ-like domain; Region: PQQ_2; pfam13360 204669013679 active site 204669013680 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 204669013681 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 204669013682 anti sigma factor interaction site; other site 204669013683 regulatory phosphorylation site [posttranslational modification]; other site 204669013684 Cupin domain; Region: Cupin_2; cl17218 204669013685 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 204669013686 Predicted transcriptional regulator [Transcription]; Region: COG3905 204669013687 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 204669013688 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 204669013689 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 204669013690 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 204669013691 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 204669013692 catalytic residues [active]