-- dump date 20140619_023607 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1261131000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1261131000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1261131000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1261131000004 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1261131000005 DnaA box-binding interface [nucleotide binding]; other site 1261131000006 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 1261131000007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1261131000008 FeS/SAM binding site; other site 1261131000009 HemN C-terminal domain; Region: HemN_C; pfam06969 1261131000010 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1261131000011 dimerization interface [polypeptide binding]; other site 1261131000012 active site 1261131000013 ribonuclease PH; Reviewed; Region: rph; PRK00173 1261131000014 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1261131000015 hexamer interface [polypeptide binding]; other site 1261131000016 active site 1261131000017 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1261131000018 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1261131000019 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1261131000020 Imelysin; Region: Peptidase_M75; cl09159 1261131000021 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1261131000022 catalytic site [active] 1261131000023 putative active site [active] 1261131000024 putative substrate binding site [chemical binding]; other site 1261131000025 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1261131000026 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1261131000027 nucleotide binding site [chemical binding]; other site 1261131000028 NEF interaction site [polypeptide binding]; other site 1261131000029 SBD interface [polypeptide binding]; other site 1261131000030 chaperone protein DnaJ; Provisional; Region: PRK10767 1261131000031 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1261131000032 HSP70 interaction site [polypeptide binding]; other site 1261131000033 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1261131000034 substrate binding site [polypeptide binding]; other site 1261131000035 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1261131000036 Zn binding sites [ion binding]; other site 1261131000037 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1261131000038 dimer interface [polypeptide binding]; other site 1261131000039 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1261131000040 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1261131000041 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1261131000042 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1261131000043 GTP1/OBG; Region: GTP1_OBG; pfam01018 1261131000044 Obg GTPase; Region: Obg; cd01898 1261131000045 G1 box; other site 1261131000046 GTP/Mg2+ binding site [chemical binding]; other site 1261131000047 Switch I region; other site 1261131000048 G2 box; other site 1261131000049 G3 box; other site 1261131000050 Switch II region; other site 1261131000051 G4 box; other site 1261131000052 G5 box; other site 1261131000053 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1261131000054 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 1261131000055 active site 1261131000056 (T/H)XGH motif; other site 1261131000057 Protein of unknown function (DUF1465); Region: DUF1465; cl11562 1261131000058 Class I aldolases; Region: Aldolase_Class_I; cl17187 1261131000059 catalytic residue [active] 1261131000060 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1261131000061 Phosphoglycerate kinase; Region: PGK; pfam00162 1261131000062 substrate binding site [chemical binding]; other site 1261131000063 hinge regions; other site 1261131000064 ADP binding site [chemical binding]; other site 1261131000065 catalytic site [active] 1261131000066 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1261131000067 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1261131000068 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1261131000069 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1261131000070 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1261131000071 TPP-binding site [chemical binding]; other site 1261131000072 dimer interface [polypeptide binding]; other site 1261131000073 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1261131000074 PYR/PP interface [polypeptide binding]; other site 1261131000075 dimer interface [polypeptide binding]; other site 1261131000076 TPP binding site [chemical binding]; other site 1261131000077 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1261131000078 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1261131000079 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1261131000080 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1261131000081 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1261131000082 putative active site [active] 1261131000083 metal binding site [ion binding]; metal-binding site 1261131000084 homodimer binding site [polypeptide binding]; other site 1261131000085 hypothetical protein; Validated; Region: PRK00110 1261131000086 exonuclease I; Provisional; Region: sbcB; PRK11779 1261131000087 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1261131000088 active site 1261131000089 catalytic site [active] 1261131000090 substrate binding site [chemical binding]; other site 1261131000091 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1261131000092 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1261131000093 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 1261131000094 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1261131000095 active site clefts [active] 1261131000096 zinc binding site [ion binding]; other site 1261131000097 dimer interface [polypeptide binding]; other site 1261131000098 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1261131000099 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1261131000100 purine monophosphate binding site [chemical binding]; other site 1261131000101 dimer interface [polypeptide binding]; other site 1261131000102 putative catalytic residues [active] 1261131000103 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1261131000104 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1261131000105 NusB family; Region: NusB; pfam01029 1261131000106 putative RNA binding site [nucleotide binding]; other site 1261131000107 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1261131000108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1261131000109 S-adenosylmethionine binding site [chemical binding]; other site 1261131000110 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 1261131000111 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 1261131000112 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1261131000113 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1261131000114 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1261131000115 active site 1261131000116 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1261131000117 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1261131000118 Membrane fusogenic activity; Region: BMFP; cl01115 1261131000119 glutathione synthetase; Provisional; Region: PRK05246 1261131000120 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1261131000121 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1261131000122 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 1261131000123 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1261131000124 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1261131000125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1261131000126 putative active site [active] 1261131000127 heme pocket [chemical binding]; other site 1261131000128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1261131000129 dimer interface [polypeptide binding]; other site 1261131000130 phosphorylation site [posttranslational modification] 1261131000131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1261131000132 ATP binding site [chemical binding]; other site 1261131000133 Mg2+ binding site [ion binding]; other site 1261131000134 G-X-G motif; other site 1261131000135 GMP synthase; Reviewed; Region: guaA; PRK00074 1261131000136 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1261131000137 AMP/PPi binding site [chemical binding]; other site 1261131000138 candidate oxyanion hole; other site 1261131000139 catalytic triad [active] 1261131000140 potential glutamine specificity residues [chemical binding]; other site 1261131000141 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1261131000142 ATP Binding subdomain [chemical binding]; other site 1261131000143 Ligand Binding sites [chemical binding]; other site 1261131000144 Dimerization subdomain; other site 1261131000145 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1261131000146 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1261131000147 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1261131000148 Transporter associated domain; Region: CorC_HlyC; smart01091 1261131000149 Ferredoxin [Energy production and conversion]; Region: COG1146 1261131000150 4Fe-4S binding domain; Region: Fer4; pfam00037 1261131000151 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1261131000152 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1261131000153 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1261131000154 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1261131000155 5S rRNA interface [nucleotide binding]; other site 1261131000156 CTC domain interface [polypeptide binding]; other site 1261131000157 L16 interface [polypeptide binding]; other site 1261131000158 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1261131000159 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1261131000160 dimer interface [polypeptide binding]; other site 1261131000161 anticodon binding site; other site 1261131000162 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1261131000163 homodimer interface [polypeptide binding]; other site 1261131000164 motif 1; other site 1261131000165 active site 1261131000166 motif 2; other site 1261131000167 GAD domain; Region: GAD; pfam02938 1261131000168 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1261131000169 active site 1261131000170 motif 3; other site 1261131000171 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1261131000172 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1261131000173 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1261131000174 catalytic site [active] 1261131000175 subunit interface [polypeptide binding]; other site 1261131000176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 1261131000177 GTP-binding protein Der; Reviewed; Region: PRK00093 1261131000178 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1261131000179 G1 box; other site 1261131000180 GTP/Mg2+ binding site [chemical binding]; other site 1261131000181 Switch I region; other site 1261131000182 G2 box; other site 1261131000183 Switch II region; other site 1261131000184 G3 box; other site 1261131000185 G4 box; other site 1261131000186 G5 box; other site 1261131000187 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1261131000188 G1 box; other site 1261131000189 GTP/Mg2+ binding site [chemical binding]; other site 1261131000190 Switch I region; other site 1261131000191 G2 box; other site 1261131000192 G3 box; other site 1261131000193 Switch II region; other site 1261131000194 G4 box; other site 1261131000195 G5 box; other site 1261131000196 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1261131000197 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1261131000198 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1261131000199 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1261131000200 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1261131000201 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1261131000202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1261131000203 non-specific DNA binding site [nucleotide binding]; other site 1261131000204 salt bridge; other site 1261131000205 sequence-specific DNA binding site [nucleotide binding]; other site 1261131000206 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1261131000207 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1261131000208 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1261131000209 Transporter associated domain; Region: CorC_HlyC; smart01091 1261131000210 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1261131000211 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1261131000212 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1261131000213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1261131000214 FeS/SAM binding site; other site 1261131000215 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1261131000216 Glycoprotease family; Region: Peptidase_M22; pfam00814 1261131000217 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 1261131000218 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1261131000219 GcrA cell cycle regulator; Region: GcrA; cl11564 1261131000220 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 1261131000221 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1261131000222 inhibitor-cofactor binding pocket; inhibition site 1261131000223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1261131000224 catalytic residue [active] 1261131000225 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1261131000226 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1261131000227 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1261131000228 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1261131000229 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1261131000230 quinone interaction residues [chemical binding]; other site 1261131000231 active site 1261131000232 catalytic residues [active] 1261131000233 FMN binding site [chemical binding]; other site 1261131000234 substrate binding site [chemical binding]; other site 1261131000235 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1261131000236 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1261131000237 TPR repeat; Region: TPR_11; pfam13414 1261131000238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1261131000239 TPR motif; other site 1261131000240 binding surface 1261131000241 TPR repeat; Region: TPR_11; pfam13414 1261131000242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1261131000243 binding surface 1261131000244 TPR motif; other site 1261131000245 TPR repeat; Region: TPR_11; pfam13414 1261131000246 TPR repeat; Region: TPR_11; pfam13414 1261131000247 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 1261131000248 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 1261131000249 active site 1261131000250 hydrophilic channel; other site 1261131000251 dimerization interface [polypeptide binding]; other site 1261131000252 catalytic residues [active] 1261131000253 active site lid [active] 1261131000254 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1261131000255 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1261131000256 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1261131000257 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1261131000258 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1261131000259 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1261131000260 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1261131000261 IMP binding site; other site 1261131000262 dimer interface [polypeptide binding]; other site 1261131000263 partial ornithine binding site; other site 1261131000264 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1261131000265 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1261131000266 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1261131000267 pyruvate kinase; Provisional; Region: PRK06247 1261131000268 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1261131000269 domain interfaces; other site 1261131000270 active site 1261131000271 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 1261131000272 Predicted transcriptional regulator [Transcription]; Region: COG2932 1261131000273 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1261131000274 Catalytic site [active] 1261131000275 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 1261131000276 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1261131000277 active site 1261131000278 HIGH motif; other site 1261131000279 nucleotide binding site [chemical binding]; other site 1261131000280 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1261131000281 active site 1261131000282 KMSKS motif; other site 1261131000283 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1261131000284 tRNA binding surface [nucleotide binding]; other site 1261131000285 anticodon binding site; other site 1261131000286 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 1261131000287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1261131000288 PAS domain; Region: PAS_9; pfam13426 1261131000289 putative active site [active] 1261131000290 heme pocket [chemical binding]; other site 1261131000291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1261131000292 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1261131000293 putative active site [active] 1261131000294 heme pocket [chemical binding]; other site 1261131000295 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1261131000296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1261131000297 dimer interface [polypeptide binding]; other site 1261131000298 phosphorylation site [posttranslational modification] 1261131000299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1261131000300 ATP binding site [chemical binding]; other site 1261131000301 Mg2+ binding site [ion binding]; other site 1261131000302 G-X-G motif; other site 1261131000303 Response regulator receiver domain; Region: Response_reg; pfam00072 1261131000304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1261131000305 active site 1261131000306 phosphorylation site [posttranslational modification] 1261131000307 intermolecular recognition site; other site 1261131000308 dimerization interface [polypeptide binding]; other site 1261131000309 aconitate hydratase; Validated; Region: PRK09277 1261131000310 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1261131000311 substrate binding site [chemical binding]; other site 1261131000312 ligand binding site [chemical binding]; other site 1261131000313 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1261131000314 substrate binding site [chemical binding]; other site 1261131000315 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1261131000316 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1261131000317 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1261131000318 active site 1261131000319 dimer interface [polypeptide binding]; other site 1261131000320 DNA polymerase III subunit beta; Validated; Region: PRK05643 1261131000321 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1261131000322 putative DNA binding surface [nucleotide binding]; other site 1261131000323 dimer interface [polypeptide binding]; other site 1261131000324 beta-clamp/clamp loader binding surface; other site 1261131000325 beta-clamp/translesion DNA polymerase binding surface; other site 1261131000326 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 1261131000327 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 1261131000328 active site 1261131000329 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1261131000330 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1261131000331 RNA binding site [nucleotide binding]; other site 1261131000332 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1261131000333 RNA binding site [nucleotide binding]; other site 1261131000334 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1261131000335 RNA binding site [nucleotide binding]; other site 1261131000336 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1261131000337 RNA binding site [nucleotide binding]; other site 1261131000338 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1261131000339 RNA binding site [nucleotide binding]; other site 1261131000340 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1261131000341 RNA binding site [nucleotide binding]; other site 1261131000342 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 1261131000343 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1261131000344 CMP-binding site; other site 1261131000345 The sites determining sugar specificity; other site 1261131000346 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1261131000347 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1261131000348 hinge; other site 1261131000349 active site 1261131000350 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1261131000351 active site 1 [active] 1261131000352 dimer interface [polypeptide binding]; other site 1261131000353 active site 2 [active] 1261131000354 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1261131000355 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1261131000356 dimer interface [polypeptide binding]; other site 1261131000357 active site 1261131000358 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 1261131000359 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1261131000360 NAD binding site [chemical binding]; other site 1261131000361 homotetramer interface [polypeptide binding]; other site 1261131000362 homodimer interface [polypeptide binding]; other site 1261131000363 substrate binding site [chemical binding]; other site 1261131000364 active site 1261131000365 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1261131000366 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1261131000367 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1261131000368 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1261131000369 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1261131000370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1261131000371 catalytic residue [active] 1261131000372 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1261131000373 DNA methylase; Region: N6_N4_Mtase; pfam01555 1261131000374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1261131000375 S-adenosylmethionine binding site [chemical binding]; other site 1261131000376 hypothetical protein; Reviewed; Region: PRK12497 1261131000377 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1261131000378 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1261131000379 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 1261131000380 Mg++ binding site [ion binding]; other site 1261131000381 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1261131000382 putative active site [active] 1261131000383 PAS fold; Region: PAS_3; pfam08447 1261131000384 heme pocket [chemical binding]; other site 1261131000385 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1261131000386 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1261131000387 metal binding site [ion binding]; metal-binding site 1261131000388 active site 1261131000389 I-site; other site 1261131000390 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1261131000391 translation initiation factor IF-1; Validated; Region: infA; PRK00276 1261131000392 RNA binding site [nucleotide binding]; other site 1261131000393 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1261131000394 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1261131000395 Subunit I/III interface [polypeptide binding]; other site 1261131000396 Subunit III/IV interface [polypeptide binding]; other site 1261131000397 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1261131000398 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1261131000399 D-pathway; other site 1261131000400 Putative ubiquinol binding site [chemical binding]; other site 1261131000401 Low-spin heme (heme b) binding site [chemical binding]; other site 1261131000402 Putative water exit pathway; other site 1261131000403 Binuclear center (heme o3/CuB) [ion binding]; other site 1261131000404 K-pathway; other site 1261131000405 Putative proton exit pathway; other site 1261131000406 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1261131000407 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1261131000408 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1261131000409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1261131000410 active site 1261131000411 phosphorylation site [posttranslational modification] 1261131000412 intermolecular recognition site; other site 1261131000413 dimerization interface [polypeptide binding]; other site 1261131000414 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1261131000415 Thioredoxin; Region: Thioredoxin_4; pfam13462 1261131000416 Protein of unknown function (DUF721); Region: DUF721; cl02324 1261131000417 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 1261131000418 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 1261131000419 trimer interface [polypeptide binding]; other site 1261131000420 active site 1261131000421 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 1261131000422 trimer interface [polypeptide binding]; other site 1261131000423 active site 1261131000424 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1261131000425 ribonuclease P; Reviewed; Region: rnpA; PRK01313 1261131000426 membrane protein insertase; Provisional; Region: PRK01318 1261131000427 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1261131000428 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1261131000429 G1 box; other site 1261131000430 GTP/Mg2+ binding site [chemical binding]; other site 1261131000431 Switch I region; other site 1261131000432 G2 box; other site 1261131000433 G3 box; other site 1261131000434 Switch II region; other site 1261131000435 G4 box; other site 1261131000436 G5 box; other site 1261131000437 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1261131000438 feedback inhibition sensing region; other site 1261131000439 homohexameric interface [polypeptide binding]; other site 1261131000440 nucleotide binding site [chemical binding]; other site 1261131000441 N-acetyl-L-glutamate binding site [chemical binding]; other site 1261131000442 biotin synthase; Region: bioB; TIGR00433 1261131000443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1261131000444 FeS/SAM binding site; other site 1261131000445 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1261131000446 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1261131000447 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1261131000448 catalytic residue [active] 1261131000449 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1261131000450 AAA domain; Region: AAA_26; pfam13500 1261131000451 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1261131000452 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1261131000453 inhibitor-cofactor binding pocket; inhibition site 1261131000454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1261131000455 catalytic residue [active] 1261131000456 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1261131000457 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 1261131000458 dimer interface [polypeptide binding]; other site 1261131000459 active site 1261131000460 CoA binding pocket [chemical binding]; other site 1261131000461 Domain of unknown function DUF59; Region: DUF59; pfam01883 1261131000462 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1261131000463 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1261131000464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1261131000465 Walker A motif; other site 1261131000466 ATP binding site [chemical binding]; other site 1261131000467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1261131000468 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1261131000469 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1261131000470 active site 1261131000471 HslU subunit interaction site [polypeptide binding]; other site 1261131000472 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1261131000473 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1261131000474 active site 1261131000475 substrate-binding site [chemical binding]; other site 1261131000476 metal-binding site [ion binding] 1261131000477 ATP binding site [chemical binding]; other site 1261131000478 PAS fold; Region: PAS_7; pfam12860 1261131000479 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1261131000480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1261131000481 dimer interface [polypeptide binding]; other site 1261131000482 phosphorylation site [posttranslational modification] 1261131000483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1261131000484 ATP binding site [chemical binding]; other site 1261131000485 Mg2+ binding site [ion binding]; other site 1261131000486 G-X-G motif; other site 1261131000487 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1261131000488 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 1261131000489 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1261131000490 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 1261131000491 Part of AAA domain; Region: AAA_19; pfam13245 1261131000492 Family description; Region: UvrD_C_2; pfam13538 1261131000493 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1261131000494 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1261131000495 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1261131000496 catalytic residues [active] 1261131000497 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1261131000498 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1261131000499 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1261131000500 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1261131000501 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1261131000502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1261131000503 Mg2+ binding site [ion binding]; other site 1261131000504 G-X-G motif; other site 1261131000505 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1261131000506 anchoring element; other site 1261131000507 dimer interface [polypeptide binding]; other site 1261131000508 ATP binding site [chemical binding]; other site 1261131000509 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1261131000510 active site 1261131000511 putative metal-binding site [ion binding]; other site 1261131000512 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1261131000513 Tim44-like domain; Region: Tim44; pfam04280 1261131000514 preprotein translocase subunit SecB; Validated; Region: PRK05751 1261131000515 SecA binding site; other site 1261131000516 Preprotein binding site; other site 1261131000517 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1261131000518 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1261131000519 active site 1261131000520 catalytic site [active] 1261131000521 substrate binding site [chemical binding]; other site 1261131000522 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1261131000523 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1261131000524 CoA-binding site [chemical binding]; other site 1261131000525 ATP-binding [chemical binding]; other site 1261131000526 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1261131000527 active site 1261131000528 dimer interface [polypeptide binding]; other site 1261131000529 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1261131000530 substrate binding site [chemical binding]; other site 1261131000531 active site 1261131000532 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1261131000533 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1261131000534 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1261131000535 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1261131000536 RNA binding site [nucleotide binding]; other site 1261131000537 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1261131000538 multimer interface [polypeptide binding]; other site 1261131000539 Walker A motif; other site 1261131000540 ATP binding site [chemical binding]; other site 1261131000541 Walker B motif; other site 1261131000542 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1261131000543 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1261131000544 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1261131000545 G1 box; other site 1261131000546 GTP/Mg2+ binding site [chemical binding]; other site 1261131000547 Switch I region; other site 1261131000548 G2 box; other site 1261131000549 Switch II region; other site 1261131000550 G3 box; other site 1261131000551 G4 box; other site 1261131000552 G5 box; other site 1261131000553 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1261131000554 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1261131000555 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1261131000556 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1261131000557 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1261131000558 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1261131000559 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1261131000560 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1261131000561 P-loop; other site 1261131000562 Magnesium ion binding site [ion binding]; other site 1261131000563 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1261131000564 Magnesium ion binding site [ion binding]; other site 1261131000565 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1261131000566 ParB-like nuclease domain; Region: ParBc; pfam02195 1261131000567 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 1261131000568 Lipopolysaccharide-assembly; Region: LptE; cl01125 1261131000569 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1261131000570 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1261131000571 HIGH motif; other site 1261131000572 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1261131000573 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1261131000574 active site 1261131000575 KMSKS motif; other site 1261131000576 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1261131000577 tRNA binding surface [nucleotide binding]; other site 1261131000578 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1261131000579 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1261131000580 catalytic residue [active] 1261131000581 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 1261131000582 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1261131000583 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1261131000584 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1261131000585 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1261131000586 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1261131000587 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1261131000588 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1261131000589 putative catalytic site [active] 1261131000590 putative metal binding site [ion binding]; other site 1261131000591 putative phosphate binding site [ion binding]; other site 1261131000592 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1261131000593 RNA/DNA hybrid binding site [nucleotide binding]; other site 1261131000594 active site 1261131000595 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1261131000596 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1261131000597 putative active site [active] 1261131000598 putative substrate binding site [chemical binding]; other site 1261131000599 ATP binding site [chemical binding]; other site 1261131000600 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1261131000601 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1261131000602 active site 1261131000603 HIGH motif; other site 1261131000604 dimer interface [polypeptide binding]; other site 1261131000605 KMSKS motif; other site 1261131000606 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1261131000607 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1261131000608 cofactor binding site; other site 1261131000609 DNA binding site [nucleotide binding] 1261131000610 substrate interaction site [chemical binding]; other site 1261131000611 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1261131000612 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1261131000613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1261131000614 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1261131000615 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1261131000616 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1261131000617 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1261131000618 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1261131000619 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1261131000620 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1261131000621 generic binding surface II; other site 1261131000622 generic binding surface I; other site 1261131000623 GtrA-like protein; Region: GtrA; pfam04138 1261131000624 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1261131000625 Sm and related proteins; Region: Sm_like; cl00259 1261131000626 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1261131000627 putative oligomer interface [polypeptide binding]; other site 1261131000628 putative RNA binding site [nucleotide binding]; other site 1261131000629 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1261131000630 NusA N-terminal domain; Region: NusA_N; pfam08529 1261131000631 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1261131000632 RNA binding site [nucleotide binding]; other site 1261131000633 homodimer interface [polypeptide binding]; other site 1261131000634 NusA-like KH domain; Region: KH_5; pfam13184 1261131000635 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1261131000636 G-X-X-G motif; other site 1261131000637 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1261131000638 translation initiation factor IF-2; Region: IF-2; TIGR00487 1261131000639 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1261131000640 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1261131000641 G1 box; other site 1261131000642 putative GEF interaction site [polypeptide binding]; other site 1261131000643 GTP/Mg2+ binding site [chemical binding]; other site 1261131000644 Switch I region; other site 1261131000645 G2 box; other site 1261131000646 G3 box; other site 1261131000647 Switch II region; other site 1261131000648 G4 box; other site 1261131000649 G5 box; other site 1261131000650 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1261131000651 Translation-initiation factor 2; Region: IF-2; pfam11987 1261131000652 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1261131000653 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1261131000654 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1261131000655 16S/18S rRNA binding site [nucleotide binding]; other site 1261131000656 S13e-L30e interaction site [polypeptide binding]; other site 1261131000657 25S rRNA binding site [nucleotide binding]; other site 1261131000658 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1261131000659 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1261131000660 RNase E interface [polypeptide binding]; other site 1261131000661 trimer interface [polypeptide binding]; other site 1261131000662 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1261131000663 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1261131000664 RNase E interface [polypeptide binding]; other site 1261131000665 trimer interface [polypeptide binding]; other site 1261131000666 active site 1261131000667 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1261131000668 putative nucleic acid binding region [nucleotide binding]; other site 1261131000669 G-X-X-G motif; other site 1261131000670 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1261131000671 RNA binding site [nucleotide binding]; other site 1261131000672 domain interface; other site 1261131000673 Predicted transcriptional regulator [Transcription]; Region: COG4957 1261131000674 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1261131000675 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1261131000676 metal binding site [ion binding]; metal-binding site 1261131000677 dimer interface [polypeptide binding]; other site 1261131000678 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1261131000679 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1261131000680 trimer interface [polypeptide binding]; other site 1261131000681 active site 1261131000682 substrate binding site [chemical binding]; other site 1261131000683 CoA binding site [chemical binding]; other site 1261131000684 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1261131000685 HIT family signature motif; other site 1261131000686 catalytic residue [active] 1261131000687 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1261131000688 rRNA interaction site [nucleotide binding]; other site 1261131000689 S8 interaction site; other site 1261131000690 putative laminin-1 binding site; other site 1261131000691 elongation factor Ts; Provisional; Region: tsf; PRK09377 1261131000692 UBA/TS-N domain; Region: UBA; pfam00627 1261131000693 Elongation factor TS; Region: EF_TS; pfam00889 1261131000694 Elongation factor TS; Region: EF_TS; pfam00889 1261131000695 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1261131000696 putative nucleotide binding site [chemical binding]; other site 1261131000697 uridine monophosphate binding site [chemical binding]; other site 1261131000698 homohexameric interface [polypeptide binding]; other site 1261131000699 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1261131000700 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1261131000701 hinge region; other site 1261131000702 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 1261131000703 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1261131000704 catalytic residue [active] 1261131000705 putative FPP diphosphate binding site; other site 1261131000706 putative FPP binding hydrophobic cleft; other site 1261131000707 dimer interface [polypeptide binding]; other site 1261131000708 putative IPP diphosphate binding site; other site 1261131000709 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1261131000710 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1261131000711 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1261131000712 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1261131000713 active site 1261131000714 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1261131000715 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1261131000716 putative substrate binding region [chemical binding]; other site 1261131000717 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1261131000718 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1261131000719 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1261131000720 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1261131000721 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1261131000722 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1261131000723 Surface antigen; Region: Bac_surface_Ag; pfam01103 1261131000724 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1261131000725 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1261131000726 putative trimer interface [polypeptide binding]; other site 1261131000727 putative CoA binding site [chemical binding]; other site 1261131000728 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1261131000729 Bacterial SH3 domain; Region: SH3_4; pfam06347 1261131000730 Bacterial SH3 domain; Region: SH3_4; pfam06347 1261131000731 recombination protein F; Reviewed; Region: recF; PRK00064 1261131000732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1261131000733 Walker A/P-loop; other site 1261131000734 ATP binding site [chemical binding]; other site 1261131000735 Q-loop/lid; other site 1261131000736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1261131000737 ABC transporter signature motif; other site 1261131000738 Walker B; other site 1261131000739 D-loop; other site 1261131000740 H-loop/switch region; other site 1261131000741 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1261131000742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1261131000743 Walker A motif; other site 1261131000744 ATP binding site [chemical binding]; other site 1261131000745 Walker B motif; other site 1261131000746 arginine finger; other site 1261131000747 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1261131000748 hypothetical protein; Validated; Region: PRK00153 1261131000749 recombination protein RecR; Reviewed; Region: recR; PRK00076 1261131000750 RecR protein; Region: RecR; pfam02132 1261131000751 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1261131000752 putative active site [active] 1261131000753 putative metal-binding site [ion binding]; other site 1261131000754 tetramer interface [polypeptide binding]; other site 1261131000755 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1261131000756 FAD binding domain; Region: FAD_binding_4; pfam01565 1261131000757 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1261131000758 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1261131000759 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1261131000760 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1261131000761 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 1261131000762 motif 1; other site 1261131000763 dimer interface [polypeptide binding]; other site 1261131000764 active site 1261131000765 motif 2; other site 1261131000766 motif 3; other site 1261131000767 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1261131000768 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1261131000769 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1261131000770 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1261131000771 substrate binding pocket [chemical binding]; other site 1261131000772 chain length determination region; other site 1261131000773 substrate-Mg2+ binding site; other site 1261131000774 catalytic residues [active] 1261131000775 aspartate-rich region 1; other site 1261131000776 active site lid residues [active] 1261131000777 aspartate-rich region 2; other site 1261131000778 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 1261131000779 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1261131000780 peptide chain release factor 2; Provisional; Region: PRK07342 1261131000781 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1261131000782 RF-1 domain; Region: RF-1; pfam00472 1261131000783 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1261131000784 Transglycosylase; Region: Transgly; pfam00912 1261131000785 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1261131000786 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1261131000787 homodimer interface [polypeptide binding]; other site 1261131000788 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1261131000789 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 1261131000790 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1261131000791 MutS domain I; Region: MutS_I; pfam01624 1261131000792 MutS domain II; Region: MutS_II; pfam05188 1261131000793 MutS domain III; Region: MutS_III; pfam05192 1261131000794 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1261131000795 Walker A/P-loop; other site 1261131000796 ATP binding site [chemical binding]; other site 1261131000797 Q-loop/lid; other site 1261131000798 ABC transporter signature motif; other site 1261131000799 Walker B; other site 1261131000800 D-loop; other site 1261131000801 H-loop/switch region; other site 1261131000802 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1261131000803 lipoprotein signal peptidase; Provisional; Region: PRK14787 1261131000804 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1261131000805 IHF dimer interface [polypeptide binding]; other site 1261131000806 IHF - DNA interface [nucleotide binding]; other site 1261131000807 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1261131000808 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1261131000809 tandem repeat interface [polypeptide binding]; other site 1261131000810 oligomer interface [polypeptide binding]; other site 1261131000811 active site residues [active] 1261131000812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 1261131000813 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1261131000814 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1261131000815 Walker A/P-loop; other site 1261131000816 ATP binding site [chemical binding]; other site 1261131000817 Q-loop/lid; other site 1261131000818 ABC transporter signature motif; other site 1261131000819 Walker B; other site 1261131000820 D-loop; other site 1261131000821 H-loop/switch region; other site 1261131000822 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1261131000823 Fe-S cluster binding site [ion binding]; other site 1261131000824 active site 1261131000825 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1261131000826 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1261131000827 NAD(P) binding pocket [chemical binding]; other site 1261131000828 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1261131000829 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1261131000830 dimer interface [polypeptide binding]; other site 1261131000831 active site 1261131000832 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1261131000833 catalytic residues [active] 1261131000834 substrate binding site [chemical binding]; other site 1261131000835 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1261131000836 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1261131000837 Flp/Fap pilin component; Region: Flp_Fap; cl01585 1261131000838 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 1261131000839 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 1261131000840 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 1261131000841 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 1261131000842 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1261131000843 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1261131000844 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1261131000845 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1261131000846 BON domain; Region: BON; pfam04972 1261131000847 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1261131000848 Type IV pili component [Cell motility and secretion]; Region: COG5461 1261131000849 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 1261131000850 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 1261131000851 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1261131000852 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1261131000853 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1261131000854 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1261131000855 ATP binding site [chemical binding]; other site 1261131000856 Walker A motif; other site 1261131000857 hexamer interface [polypeptide binding]; other site 1261131000858 Walker B motif; other site 1261131000859 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1261131000860 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1261131000861 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1261131000862 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1261131000863 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1261131000864 Ferritin-like domain; Region: Ferritin; pfam00210 1261131000865 ferroxidase diiron center [ion binding]; other site 1261131000866 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1261131000867 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1261131000868 ABC-ATPase subunit interface; other site 1261131000869 dimer interface [polypeptide binding]; other site 1261131000870 putative PBP binding regions; other site 1261131000871 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1261131000872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1261131000873 Walker A/P-loop; other site 1261131000874 ATP binding site [chemical binding]; other site 1261131000875 Q-loop/lid; other site 1261131000876 ABC transporter signature motif; other site 1261131000877 Walker B; other site 1261131000878 D-loop; other site 1261131000879 H-loop/switch region; other site 1261131000880 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 1261131000881 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1261131000882 metal binding site [ion binding]; metal-binding site 1261131000883 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 1261131000884 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1261131000885 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1261131000886 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1261131000887 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1261131000888 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 1261131000889 RimM N-terminal domain; Region: RimM; pfam01782 1261131000890 PRC-barrel domain; Region: PRC; pfam05239 1261131000891 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1261131000892 signal recognition particle protein; Provisional; Region: PRK10867 1261131000893 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1261131000894 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1261131000895 P loop; other site 1261131000896 GTP binding site [chemical binding]; other site 1261131000897 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1261131000898 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1261131000899 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1261131000900 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1261131000901 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1261131000902 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1261131000903 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1261131000904 PBP superfamily domain; Region: PBP_like_2; pfam12849 1261131000905 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 1261131000906 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1261131000907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1261131000908 dimer interface [polypeptide binding]; other site 1261131000909 conserved gate region; other site 1261131000910 putative PBP binding loops; other site 1261131000911 ABC-ATPase subunit interface; other site 1261131000912 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1261131000913 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1261131000914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1261131000915 dimer interface [polypeptide binding]; other site 1261131000916 conserved gate region; other site 1261131000917 putative PBP binding loops; other site 1261131000918 ABC-ATPase subunit interface; other site 1261131000919 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 1261131000920 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1261131000921 Walker A/P-loop; other site 1261131000922 ATP binding site [chemical binding]; other site 1261131000923 Q-loop/lid; other site 1261131000924 ABC transporter signature motif; other site 1261131000925 Walker B; other site 1261131000926 D-loop; other site 1261131000927 H-loop/switch region; other site 1261131000928 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1261131000929 PhoU domain; Region: PhoU; pfam01895 1261131000930 PhoU domain; Region: PhoU; pfam01895 1261131000931 heat shock protein GrpE; Provisional; Region: PRK14141 1261131000932 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1261131000933 dimer interface [polypeptide binding]; other site 1261131000934 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1261131000935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1261131000936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1261131000937 dimer interface [polypeptide binding]; other site 1261131000938 phosphorylation site [posttranslational modification] 1261131000939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1261131000940 ATP binding site [chemical binding]; other site 1261131000941 Mg2+ binding site [ion binding]; other site 1261131000942 G-X-G motif; other site 1261131000943 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1261131000944 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1261131000945 protein binding site [polypeptide binding]; other site 1261131000946 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1261131000947 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1261131000948 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1261131000949 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1261131000950 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1261131000951 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1261131000952 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1261131000953 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1261131000954 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1261131000955 DNA binding residues [nucleotide binding] 1261131000956 dimerization interface [polypeptide binding]; other site 1261131000957 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1261131000958 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1261131000959 DNA binding residues [nucleotide binding] 1261131000960 dimerization interface [polypeptide binding]; other site 1261131000961 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1261131000962 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1261131000963 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1261131000964 MgtE intracellular N domain; Region: MgtE_N; cl15244 1261131000965 FliG C-terminal domain; Region: FliG_C; pfam01706 1261131000966 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1261131000967 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 1261131000968 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1261131000969 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1261131000970 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1261131000971 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 1261131000972 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1261131000973 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1261131000974 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 1261131000975 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1261131000976 Walker A motif; other site 1261131000977 ATP binding site [chemical binding]; other site 1261131000978 Walker B motif; other site 1261131000979 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 1261131000980 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1261131000981 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 1261131000982 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1261131000983 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1261131000984 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 1261131000985 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 1261131000986 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1261131000987 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 1261131000988 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1261131000989 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1261131000990 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1261131000991 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1261131000992 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1261131000993 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1261131000994 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788 1261131000995 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1261131000996 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1261131000997 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1261131000998 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1261131000999 active site 1261131001000 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1261131001001 substrate binding site [chemical binding]; other site 1261131001002 catalytic residues [active] 1261131001003 dimer interface [polypeptide binding]; other site 1261131001004 argininosuccinate lyase; Provisional; Region: PRK00855 1261131001005 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1261131001006 active sites [active] 1261131001007 tetramer interface [polypeptide binding]; other site 1261131001008 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1261131001009 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1261131001010 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1261131001011 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1261131001012 Ligand binding site [chemical binding]; other site 1261131001013 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1261131001014 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1261131001015 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1261131001016 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1261131001017 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1261131001018 FAD binding pocket [chemical binding]; other site 1261131001019 FAD binding motif [chemical binding]; other site 1261131001020 phosphate binding motif [ion binding]; other site 1261131001021 beta-alpha-beta structure motif; other site 1261131001022 NAD binding pocket [chemical binding]; other site 1261131001023 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1261131001024 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 1261131001025 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1261131001026 UbiA prenyltransferase family; Region: UbiA; pfam01040 1261131001027 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1261131001028 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1261131001029 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1261131001030 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1261131001031 Tetramer interface [polypeptide binding]; other site 1261131001032 active site 1261131001033 FMN-binding site [chemical binding]; other site 1261131001034 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1261131001035 nucleoside/Zn binding site; other site 1261131001036 dimer interface [polypeptide binding]; other site 1261131001037 catalytic motif [active] 1261131001038 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1261131001039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1261131001040 RNA binding surface [nucleotide binding]; other site 1261131001041 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1261131001042 active site 1261131001043 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1261131001044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1261131001045 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1261131001046 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1261131001047 active site 1261131001048 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 1261131001049 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; cl11535 1261131001050 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1261131001051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1261131001052 ATP binding site [chemical binding]; other site 1261131001053 Mg2+ binding site [ion binding]; other site 1261131001054 G-X-G motif; other site 1261131001055 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 1261131001056 ATP binding site [chemical binding]; other site 1261131001057 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1261131001058 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1261131001059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1261131001060 S-adenosylmethionine binding site [chemical binding]; other site 1261131001061 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 1261131001062 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1261131001063 SurA N-terminal domain; Region: SurA_N; pfam09312 1261131001064 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1261131001065 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1261131001066 Predicted permeases [General function prediction only]; Region: COG0795 1261131001067 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1261131001068 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1261131001069 Predicted permeases [General function prediction only]; Region: COG0795 1261131001070 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1261131001071 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1261131001072 interface (dimer of trimers) [polypeptide binding]; other site 1261131001073 Substrate-binding/catalytic site; other site 1261131001074 Zn-binding sites [ion binding]; other site 1261131001075 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 1261131001076 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1261131001077 active site 1261131001078 multimer interface [polypeptide binding]; other site 1261131001079 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1261131001080 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1261131001081 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1261131001082 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1261131001083 minor groove reading motif; other site 1261131001084 helix-hairpin-helix signature motif; other site 1261131001085 substrate binding pocket [chemical binding]; other site 1261131001086 active site 1261131001087 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1261131001088 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1261131001089 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1261131001090 ATP binding site [chemical binding]; other site 1261131001091 Mg++ binding site [ion binding]; other site 1261131001092 motif III; other site 1261131001093 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1261131001094 nucleotide binding region [chemical binding]; other site 1261131001095 ATP-binding site [chemical binding]; other site 1261131001096 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1261131001097 seryl-tRNA synthetase; Provisional; Region: PRK05431 1261131001098 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1261131001099 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1261131001100 dimer interface [polypeptide binding]; other site 1261131001101 active site 1261131001102 motif 1; other site 1261131001103 motif 2; other site 1261131001104 motif 3; other site 1261131001105 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1261131001106 putative coenzyme Q binding site [chemical binding]; other site 1261131001107 lipoyl synthase; Provisional; Region: PRK05481 1261131001108 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1261131001109 FeS/SAM binding site; other site 1261131001110 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1261131001111 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1261131001112 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1261131001113 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1261131001114 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1261131001115 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 1261131001116 E3 interaction surface; other site 1261131001117 lipoyl attachment site [posttranslational modification]; other site 1261131001118 e3 binding domain; Region: E3_binding; pfam02817 1261131001119 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1261131001120 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 1261131001121 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1261131001122 E3 interaction surface; other site 1261131001123 lipoyl attachment site [posttranslational modification]; other site 1261131001124 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1261131001125 alpha subunit interface [polypeptide binding]; other site 1261131001126 TPP binding site [chemical binding]; other site 1261131001127 heterodimer interface [polypeptide binding]; other site 1261131001128 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1261131001129 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1261131001130 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1261131001131 tetramer interface [polypeptide binding]; other site 1261131001132 TPP-binding site [chemical binding]; other site 1261131001133 heterodimer interface [polypeptide binding]; other site 1261131001134 phosphorylation loop region [posttranslational modification] 1261131001135 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1261131001136 Septum formation initiator; Region: DivIC; pfam04977 1261131001137 enolase; Provisional; Region: eno; PRK00077 1261131001138 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1261131001139 dimer interface [polypeptide binding]; other site 1261131001140 metal binding site [ion binding]; metal-binding site 1261131001141 substrate binding pocket [chemical binding]; other site 1261131001142 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1261131001143 Competence protein; Region: Competence; pfam03772 1261131001144 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1261131001145 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1261131001146 dimer interface [polypeptide binding]; other site 1261131001147 active site 1261131001148 citrylCoA binding site [chemical binding]; other site 1261131001149 NADH binding [chemical binding]; other site 1261131001150 cationic pore residues; other site 1261131001151 oxalacetate/citrate binding site [chemical binding]; other site 1261131001152 coenzyme A binding site [chemical binding]; other site 1261131001153 catalytic triad [active] 1261131001154 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1261131001155 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1261131001156 CAP-like domain; other site 1261131001157 active site 1261131001158 primary dimer interface [polypeptide binding]; other site 1261131001159 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1261131001160 dimer interface [polypeptide binding]; other site 1261131001161 active site 1261131001162 aspartate-rich active site metal binding site; other site 1261131001163 allosteric magnesium binding site [ion binding]; other site 1261131001164 Schiff base residues; other site 1261131001165 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1261131001166 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1261131001167 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1261131001168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1261131001169 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1261131001170 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1261131001171 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1261131001172 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1261131001173 dimer interface [polypeptide binding]; other site 1261131001174 active site 1261131001175 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1261131001176 folate binding site [chemical binding]; other site 1261131001177 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1261131001178 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1261131001179 catalytic motif [active] 1261131001180 Zn binding site [ion binding]; other site 1261131001181 RibD C-terminal domain; Region: RibD_C; cl17279 1261131001182 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1261131001183 Lumazine binding domain; Region: Lum_binding; pfam00677 1261131001184 Lumazine binding domain; Region: Lum_binding; pfam00677 1261131001185 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1261131001186 homopentamer interface [polypeptide binding]; other site 1261131001187 active site 1261131001188 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1261131001189 putative RNA binding site [nucleotide binding]; other site 1261131001190 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1261131001191 Cation efflux family; Region: Cation_efflux; pfam01545 1261131001192 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1261131001193 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1261131001194 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1261131001195 glutamine binding [chemical binding]; other site 1261131001196 catalytic triad [active] 1261131001197 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1261131001198 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1261131001199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1261131001200 dimer interface [polypeptide binding]; other site 1261131001201 conserved gate region; other site 1261131001202 putative PBP binding loops; other site 1261131001203 ABC-ATPase subunit interface; other site 1261131001204 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1261131001205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1261131001206 Walker A/P-loop; other site 1261131001207 ATP binding site [chemical binding]; other site 1261131001208 Q-loop/lid; other site 1261131001209 ABC transporter signature motif; other site 1261131001210 Walker B; other site 1261131001211 D-loop; other site 1261131001212 H-loop/switch region; other site 1261131001213 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1261131001214 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1261131001215 classical (c) SDRs; Region: SDR_c; cd05233 1261131001216 NAD(P) binding site [chemical binding]; other site 1261131001217 active site 1261131001218 amidophosphoribosyltransferase; Provisional; Region: PRK09123 1261131001219 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1261131001220 active site 1261131001221 tetramer interface [polypeptide binding]; other site 1261131001222 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1261131001223 active site 1261131001224 Colicin V production protein; Region: Colicin_V; pfam02674 1261131001225 DNA repair protein RadA; Provisional; Region: PRK11823 1261131001226 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1261131001227 Walker A motif; other site 1261131001228 ATP binding site [chemical binding]; other site 1261131001229 Walker B motif; other site 1261131001230 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1261131001231 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1261131001232 active site 1261131001233 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1261131001234 dimer interface [polypeptide binding]; other site 1261131001235 substrate binding site [chemical binding]; other site 1261131001236 catalytic residues [active] 1261131001237 replicative DNA helicase; Provisional; Region: PRK09165 1261131001238 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1261131001239 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1261131001240 Walker A motif; other site 1261131001241 ATP binding site [chemical binding]; other site 1261131001242 Walker B motif; other site 1261131001243 DNA binding loops [nucleotide binding] 1261131001244 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1261131001245 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1261131001246 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1261131001247 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1261131001248 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1261131001249 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1261131001250 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1261131001251 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1261131001252 SEC-C motif; Region: SEC-C; pfam02810 1261131001253 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1261131001254 heterotetramer interface [polypeptide binding]; other site 1261131001255 active site pocket [active] 1261131001256 cleavage site 1261131001257 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1261131001258 active site 1261131001259 8-oxo-dGMP binding site [chemical binding]; other site 1261131001260 nudix motif; other site 1261131001261 metal binding site [ion binding]; metal-binding site 1261131001262 TLC ATP/ADP transporter; Region: TLC; pfam03219 1261131001263 S-adenosylmethionine binding site [chemical binding]; other site 1261131001264 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1261131001265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1261131001266 GTP-binding protein LepA; Provisional; Region: PRK05433 1261131001267 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1261131001268 G1 box; other site 1261131001269 putative GEF interaction site [polypeptide binding]; other site 1261131001270 GTP/Mg2+ binding site [chemical binding]; other site 1261131001271 Switch I region; other site 1261131001272 G2 box; other site 1261131001273 G3 box; other site 1261131001274 Switch II region; other site 1261131001275 G4 box; other site 1261131001276 G5 box; other site 1261131001277 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1261131001278 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1261131001279 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1261131001280 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1261131001281 translation initiation factor IF-3; Region: infC; TIGR00168 1261131001282 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1261131001283 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1261131001284 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1261131001285 23S rRNA binding site [nucleotide binding]; other site 1261131001286 L21 binding site [polypeptide binding]; other site 1261131001287 L13 binding site [polypeptide binding]; other site 1261131001288 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1261131001289 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1261131001290 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1261131001291 dimer interface [polypeptide binding]; other site 1261131001292 motif 1; other site 1261131001293 active site 1261131001294 motif 2; other site 1261131001295 motif 3; other site 1261131001296 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1261131001297 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1261131001298 putative tRNA-binding site [nucleotide binding]; other site 1261131001299 B3/4 domain; Region: B3_4; pfam03483 1261131001300 tRNA synthetase B5 domain; Region: B5; smart00874 1261131001301 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1261131001302 dimer interface [polypeptide binding]; other site 1261131001303 motif 1; other site 1261131001304 motif 3; other site 1261131001305 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1261131001306 Porin subfamily; Region: Porin_2; pfam02530 1261131001307 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1261131001308 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1261131001309 Response regulator receiver domain; Region: Response_reg; pfam00072 1261131001310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1261131001311 active site 1261131001312 phosphorylation site [posttranslational modification] 1261131001313 intermolecular recognition site; other site 1261131001314 dimerization interface [polypeptide binding]; other site 1261131001315 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1261131001316 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1261131001317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1261131001318 dimer interface [polypeptide binding]; other site 1261131001319 conserved gate region; other site 1261131001320 ABC-ATPase subunit interface; other site 1261131001321 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1261131001322 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1261131001323 Walker A/P-loop; other site 1261131001324 ATP binding site [chemical binding]; other site 1261131001325 Q-loop/lid; other site 1261131001326 ABC transporter signature motif; other site 1261131001327 Walker B; other site 1261131001328 D-loop; other site 1261131001329 H-loop/switch region; other site 1261131001330 NIL domain; Region: NIL; pfam09383 1261131001331 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1261131001332 catalytic triad [active] 1261131001333 dimer interface [polypeptide binding]; other site 1261131001334 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1261131001335 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1261131001336 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1261131001337 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1261131001338 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1261131001339 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1261131001340 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1261131001341 active site 1261131001342 interdomain interaction site; other site 1261131001343 putative metal-binding site [ion binding]; other site 1261131001344 nucleotide binding site [chemical binding]; other site 1261131001345 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1261131001346 domain I; other site 1261131001347 DNA binding groove [nucleotide binding] 1261131001348 phosphate binding site [ion binding]; other site 1261131001349 domain II; other site 1261131001350 domain III; other site 1261131001351 nucleotide binding site [chemical binding]; other site 1261131001352 catalytic site [active] 1261131001353 domain IV; other site 1261131001354 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1261131001355 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1261131001356 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1261131001357 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1261131001358 DNA protecting protein DprA; Region: dprA; TIGR00732 1261131001359 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1261131001360 dihydroorotase; Validated; Region: PRK09059 1261131001361 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1261131001362 active site 1261131001363 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1261131001364 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1261131001365 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1261131001366 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1261131001367 active site 1261131001368 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1261131001369 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1261131001370 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1261131001371 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1261131001372 ligand binding site [chemical binding]; other site 1261131001373 chemotaxis protein; Reviewed; Region: PRK12798 1261131001374 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1261131001375 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1261131001376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1261131001377 active site 1261131001378 intermolecular recognition site; other site 1261131001379 dimerization interface [polypeptide binding]; other site 1261131001380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1261131001381 DNA binding site [nucleotide binding] 1261131001382 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1261131001383 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1261131001384 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1261131001385 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1261131001386 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 1261131001387 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 1261131001388 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1261131001389 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1261131001390 Flagellar protein FlaF; Region: FlaF; cl11454 1261131001391 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 1261131001392 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 1261131001393 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1261131001394 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 1261131001395 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1261131001396 FHIPEP family; Region: FHIPEP; pfam00771 1261131001397 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1261131001398 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 1261131001399 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1261131001400 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1261131001401 homodimer interface [polypeptide binding]; other site 1261131001402 NADP binding site [chemical binding]; other site 1261131001403 substrate binding site [chemical binding]; other site 1261131001404 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1261131001405 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1261131001406 putative active site [active] 1261131001407 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1261131001408 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1261131001409 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1261131001410 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1261131001411 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1261131001412 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1261131001413 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1261131001414 dimer interface [polypeptide binding]; other site 1261131001415 putative radical transfer pathway; other site 1261131001416 diiron center [ion binding]; other site 1261131001417 tyrosyl radical; other site 1261131001418 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1261131001419 ATP cone domain; Region: ATP-cone; pfam03477 1261131001420 ATP cone domain; Region: ATP-cone; pfam03477 1261131001421 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1261131001422 active site 1261131001423 dimer interface [polypeptide binding]; other site 1261131001424 catalytic residues [active] 1261131001425 effector binding site; other site 1261131001426 R2 peptide binding site; other site 1261131001427 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1261131001428 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1261131001429 putative phosphate acyltransferase; Provisional; Region: PRK05331 1261131001430 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1261131001431 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1261131001432 dimer interface [polypeptide binding]; other site 1261131001433 active site 1261131001434 CoA binding pocket [chemical binding]; other site 1261131001435 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1261131001436 IHF dimer interface [polypeptide binding]; other site 1261131001437 IHF - DNA interface [nucleotide binding]; other site 1261131001438 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1261131001439 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1261131001440 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1261131001441 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1261131001442 Cation efflux family; Region: Cation_efflux; cl00316 1261131001443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 1261131001444 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1261131001445 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1261131001446 active site 1261131001447 HIGH motif; other site 1261131001448 nucleotide binding site [chemical binding]; other site 1261131001449 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1261131001450 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1261131001451 active site 1261131001452 KMSKS motif; other site 1261131001453 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1261131001454 tRNA binding surface [nucleotide binding]; other site 1261131001455 anticodon binding site; other site 1261131001456 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1261131001457 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1261131001458 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1261131001459 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1261131001460 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1261131001461 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1261131001462 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1261131001463 dimer interface [polypeptide binding]; other site 1261131001464 ssDNA binding site [nucleotide binding]; other site 1261131001465 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1261131001466 DNA gyrase subunit A; Validated; Region: PRK05560 1261131001467 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1261131001468 CAP-like domain; other site 1261131001469 active site 1261131001470 primary dimer interface [polypeptide binding]; other site 1261131001471 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1261131001472 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1261131001473 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1261131001474 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1261131001475 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1261131001476 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1261131001477 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1261131001478 active site 1261131001479 nucleotide binding site [chemical binding]; other site 1261131001480 HIGH motif; other site 1261131001481 KMSKS motif; other site 1261131001482 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1261131001483 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1261131001484 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1261131001485 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1261131001486 lipoate-protein ligase B; Provisional; Region: PRK14341 1261131001487 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1261131001488 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1261131001489 catalytic triad [active] 1261131001490 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1261131001491 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1261131001492 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1261131001493 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1261131001494 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 1261131001495 UbiA prenyltransferase family; Region: UbiA; pfam01040 1261131001496 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1261131001497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1261131001498 FeS/SAM binding site; other site 1261131001499 ferrochelatase; Reviewed; Region: hemH; PRK00035 1261131001500 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1261131001501 C-terminal domain interface [polypeptide binding]; other site 1261131001502 active site 1261131001503 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1261131001504 active site 1261131001505 N-terminal domain interface [polypeptide binding]; other site 1261131001506 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1261131001507 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1261131001508 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1261131001509 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 1261131001510 active site 1261131001511 Zn binding site [ion binding]; other site 1261131001512 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1261131001513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1261131001514 Walker A motif; other site 1261131001515 ATP binding site [chemical binding]; other site 1261131001516 Walker B motif; other site 1261131001517 arginine finger; other site 1261131001518 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1261131001519 DNA-binding interface [nucleotide binding]; DNA binding site 1261131001520 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1261131001521 Class II fumarases; Region: Fumarase_classII; cd01362 1261131001522 active site 1261131001523 tetramer interface [polypeptide binding]; other site 1261131001524 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 1261131001525 ATP-grasp domain; Region: ATP-grasp; pfam02222 1261131001526 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1261131001527 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1261131001528 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1261131001529 active site 1261131001530 dimerization interface [polypeptide binding]; other site 1261131001531 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 1261131001532 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1261131001533 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1261131001534 catalytic residue [active] 1261131001535 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1261131001536 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1261131001537 Ligand Binding Site [chemical binding]; other site 1261131001538 elongation factor Tu; Reviewed; Region: PRK00049 1261131001539 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1261131001540 G1 box; other site 1261131001541 GEF interaction site [polypeptide binding]; other site 1261131001542 GTP/Mg2+ binding site [chemical binding]; other site 1261131001543 Switch I region; other site 1261131001544 G2 box; other site 1261131001545 G3 box; other site 1261131001546 Switch II region; other site 1261131001547 G4 box; other site 1261131001548 G5 box; other site 1261131001549 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1261131001550 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1261131001551 Antibiotic Binding Site [chemical binding]; other site 1261131001552 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1261131001553 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1261131001554 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1261131001555 putative homodimer interface [polypeptide binding]; other site 1261131001556 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1261131001557 heterodimer interface [polypeptide binding]; other site 1261131001558 homodimer interface [polypeptide binding]; other site 1261131001559 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1261131001560 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1261131001561 23S rRNA interface [nucleotide binding]; other site 1261131001562 L7/L12 interface [polypeptide binding]; other site 1261131001563 putative thiostrepton binding site; other site 1261131001564 L25 interface [polypeptide binding]; other site 1261131001565 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1261131001566 mRNA/rRNA interface [nucleotide binding]; other site 1261131001567 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1261131001568 23S rRNA interface [nucleotide binding]; other site 1261131001569 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1261131001570 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1261131001571 peripheral dimer interface [polypeptide binding]; other site 1261131001572 core dimer interface [polypeptide binding]; other site 1261131001573 L10 interface [polypeptide binding]; other site 1261131001574 L11 interface [polypeptide binding]; other site 1261131001575 putative EF-Tu interaction site [polypeptide binding]; other site 1261131001576 putative EF-G interaction site [polypeptide binding]; other site 1261131001577 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1261131001578 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1261131001579 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1261131001580 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1261131001581 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1261131001582 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1261131001583 RPB3 interaction site [polypeptide binding]; other site 1261131001584 RPB1 interaction site [polypeptide binding]; other site 1261131001585 RPB11 interaction site [polypeptide binding]; other site 1261131001586 RPB10 interaction site [polypeptide binding]; other site 1261131001587 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1261131001588 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1261131001589 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1261131001590 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1261131001591 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1261131001592 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1261131001593 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1261131001594 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1261131001595 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1261131001596 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 1261131001597 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1261131001598 DNA binding site [nucleotide binding] 1261131001599 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1261131001600 Protein of unknown function (DUF330); Region: DUF330; cl01135 1261131001601 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1261131001602 mce related protein; Region: MCE; pfam02470 1261131001603 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1261131001604 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1261131001605 Walker A/P-loop; other site 1261131001606 ATP binding site [chemical binding]; other site 1261131001607 Q-loop/lid; other site 1261131001608 ABC transporter signature motif; other site 1261131001609 Walker B; other site 1261131001610 D-loop; other site 1261131001611 H-loop/switch region; other site 1261131001612 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1261131001613 Permease; Region: Permease; pfam02405 1261131001614 malic enzyme; Reviewed; Region: PRK12862 1261131001615 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1261131001616 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1261131001617 putative NAD(P) binding site [chemical binding]; other site 1261131001618 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1261131001619 cell division protein MraZ; Reviewed; Region: PRK00326 1261131001620 MraZ protein; Region: MraZ; pfam02381 1261131001621 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1261131001622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1261131001623 S-adenosylmethionine binding site [chemical binding]; other site 1261131001624 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 1261131001625 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1261131001626 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1261131001627 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1261131001628 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1261131001629 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1261131001630 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1261131001631 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1261131001632 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 1261131001633 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1261131001634 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1261131001635 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1261131001636 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1261131001637 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1261131001638 Mg++ binding site [ion binding]; other site 1261131001639 putative catalytic motif [active] 1261131001640 putative substrate binding site [chemical binding]; other site 1261131001641 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 1261131001642 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 1261131001643 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1261131001644 cell division protein FtsW; Region: ftsW; TIGR02614 1261131001645 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1261131001646 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1261131001647 active site 1261131001648 homodimer interface [polypeptide binding]; other site 1261131001649 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1261131001650 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1261131001651 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1261131001652 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1261131001653 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1261131001654 RNA/DNA hybrid binding site [nucleotide binding]; other site 1261131001655 active site 1261131001656 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1261131001657 Protein of unknown function (DUF1376); Region: DUF1376; pfam07120 1261131001658 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 1261131001659 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1261131001660 Walker A motif; other site 1261131001661 ATP binding site [chemical binding]; other site 1261131001662 Walker B motif; other site 1261131001663 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1261131001664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1261131001665 non-specific DNA binding site [nucleotide binding]; other site 1261131001666 salt bridge; other site 1261131001667 sequence-specific DNA binding site [nucleotide binding]; other site 1261131001668 Terminase-like family; Region: Terminase_6; pfam03237 1261131001669 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 1261131001670 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1261131001671 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1261131001672 Fe2+ transport protein; Region: Iron_transport; pfam10634 1261131001673 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1261131001674 Iron permease FTR1 family; Region: FTR1; cl00475 1261131001675 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1261131001676 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1261131001677 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1261131001678 Peptidase family M23; Region: Peptidase_M23; pfam01551 1261131001679 Domain of unknown function DUF59; Region: DUF59; pfam01883 1261131001680 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1261131001681 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1261131001682 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1261131001683 active site 1261131001684 DNA binding site [nucleotide binding] 1261131001685 Int/Topo IB signature motif; other site 1261131001686 hypothetical protein; Validated; Region: PRK00041 1261131001687 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1261131001688 GTP cyclohydrolase I; Provisional; Region: PLN03044 1261131001689 active site 1261131001690 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1261131001691 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1261131001692 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 1261131001693 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1261131001694 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1261131001695 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1261131001696 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA_subfamily_ECM; cd01450 1261131001697 integrin inhibitor binding pocket; other site 1261131001698 metal ion-dependent adhesion site (MIDAS); other site 1261131001699 integrin-collagen binding site; other site 1261131001700 putative vWF-collagen binding site; other site 1261131001701 glycoprotein Ib (GpIb) binding site [polypeptide binding]; other site 1261131001702 metabolite-proton symporter; Region: 2A0106; TIGR00883 1261131001703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1261131001704 putative substrate translocation pore; other site 1261131001705 PilZ domain; Region: PilZ; pfam07238 1261131001706 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1261131001707 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1261131001708 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1261131001709 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1261131001710 active site 1261131001711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 1261131001712 Response regulator receiver domain; Region: Response_reg; pfam00072 1261131001713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1261131001714 active site 1261131001715 phosphorylation site [posttranslational modification] 1261131001716 intermolecular recognition site; other site 1261131001717 dimerization interface [polypeptide binding]; other site 1261131001718 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1261131001719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1261131001720 active site 1261131001721 phosphorylation site [posttranslational modification] 1261131001722 intermolecular recognition site; other site 1261131001723 dimerization interface [polypeptide binding]; other site 1261131001724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1261131001725 DNA binding site [nucleotide binding] 1261131001726 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 1261131001727 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1261131001728 TM-ABC transporter signature motif; other site 1261131001729 trigger factor; Provisional; Region: tig; PRK01490 1261131001730 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1261131001731 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1261131001732 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 1261131001733 hypothetical protein; Reviewed; Region: PRK00024 1261131001734 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1261131001735 MPN+ (JAMM) motif; other site 1261131001736 Zinc-binding site [ion binding]; other site 1261131001737 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1261131001738 active site 1261131001739 homoserine dehydrogenase; Provisional; Region: PRK06349 1261131001740 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1261131001741 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1261131001742 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1261131001743 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1261131001744 DHH family; Region: DHH; pfam01368 1261131001745 DHHA1 domain; Region: DHHA1; pfam02272 1261131001746 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1261131001747 DNA-binding site [nucleotide binding]; DNA binding site 1261131001748 RNA-binding motif; other site 1261131001749 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1261131001750 DNA-binding site [nucleotide binding]; DNA binding site 1261131001751 RNA-binding motif; other site 1261131001752 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 1261131001753 recombinase A; Provisional; Region: recA; PRK09354 1261131001754 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1261131001755 hexamer interface [polypeptide binding]; other site 1261131001756 Walker A motif; other site 1261131001757 ATP binding site [chemical binding]; other site 1261131001758 Walker B motif; other site 1261131001759 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1261131001760 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1261131001761 motif 1; other site 1261131001762 active site 1261131001763 motif 2; other site 1261131001764 motif 3; other site 1261131001765 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1261131001766 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1261131001767 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1261131001768 putative active site [active] 1261131001769 putative PHP Thumb interface [polypeptide binding]; other site 1261131001770 DNA primase; Validated; Region: dnaG; PRK05667 1261131001771 CHC2 zinc finger; Region: zf-CHC2; cl17510 1261131001772 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1261131001773 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1261131001774 active site 1261131001775 metal binding site [ion binding]; metal-binding site 1261131001776 interdomain interaction site; other site 1261131001777 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1261131001778 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1261131001779 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1261131001780 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 1261131001781 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1261131001782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1261131001783 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1261131001784 putative substrate translocation pore; other site 1261131001785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1261131001786 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1261131001787 DNA binding site [nucleotide binding] 1261131001788 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1261131001789 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1261131001790 active site 1261131001791 Riboflavin kinase; Region: Flavokinase; smart00904 1261131001792 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1261131001793 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1261131001794 active site 1261131001795 motif I; other site 1261131001796 motif II; other site 1261131001797 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1261131001798 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1261131001799 oligomerisation interface [polypeptide binding]; other site 1261131001800 mobile loop; other site 1261131001801 roof hairpin; other site 1261131001802 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1261131001803 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1261131001804 ring oligomerisation interface [polypeptide binding]; other site 1261131001805 ATP/Mg binding site [chemical binding]; other site 1261131001806 stacking interactions; other site 1261131001807 hinge regions; other site 1261131001808 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1261131001809 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1261131001810 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1261131001811 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1261131001812 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1261131001813 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1261131001814 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1261131001815 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1261131001816 putative dimer interface [polypeptide binding]; other site 1261131001817 [2Fe-2S] cluster binding site [ion binding]; other site 1261131001818 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 1261131001819 SLBB domain; Region: SLBB; pfam10531 1261131001820 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1261131001821 NADH dehydrogenase subunit G; Validated; Region: PRK09130 1261131001822 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1261131001823 catalytic loop [active] 1261131001824 iron binding site [ion binding]; other site 1261131001825 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1261131001826 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 1261131001827 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 1261131001828 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1261131001829 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1261131001830 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1261131001831 4Fe-4S binding domain; Region: Fer4; pfam00037 1261131001832 4Fe-4S binding domain; Region: Fer4; pfam00037 1261131001833 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1261131001834 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1261131001835 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 1261131001836 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1261131001837 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1261131001838 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1261131001839 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1261131001840 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1261131001841 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1261131001842 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1261131001843 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1261131001844 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1261131001845 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1261131001846 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1261131001847 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1261131001848 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1261131001849 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1261131001850 prolyl-tRNA synthetase; Provisional; Region: PRK12325 1261131001851 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1261131001852 dimer interface [polypeptide binding]; other site 1261131001853 motif 1; other site 1261131001854 active site 1261131001855 motif 2; other site 1261131001856 motif 3; other site 1261131001857 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1261131001858 anticodon binding site; other site 1261131001859 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1261131001860 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1261131001861 FtsX-like permease family; Region: FtsX; pfam02687 1261131001862 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1261131001863 Walker A/P-loop; other site 1261131001864 ATP binding site [chemical binding]; other site 1261131001865 ABC transporter; Region: ABC_tran; pfam00005 1261131001866 Q-loop/lid; other site 1261131001867 ABC transporter signature motif; other site 1261131001868 Walker B; other site 1261131001869 D-loop; other site 1261131001870 H-loop/switch region; other site 1261131001871 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1261131001872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1261131001873 S-adenosylmethionine binding site [chemical binding]; other site 1261131001874 aspartate kinase; Reviewed; Region: PRK06635 1261131001875 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 1261131001876 putative catalytic residues [active] 1261131001877 putative nucleotide binding site [chemical binding]; other site 1261131001878 putative aspartate binding site [chemical binding]; other site 1261131001879 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1261131001880 putative allosteric regulatory site; other site 1261131001881 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1261131001882 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1261131001883 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1261131001884 RF-1 domain; Region: RF-1; pfam00472 1261131001885 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1261131001886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1261131001887 S-adenosylmethionine binding site [chemical binding]; other site 1261131001888 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 1261131001889 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1261131001890 Clp amino terminal domain; Region: Clp_N; pfam02861 1261131001891 Clp amino terminal domain; Region: Clp_N; pfam02861 1261131001892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1261131001893 Walker A motif; other site 1261131001894 ATP binding site [chemical binding]; other site 1261131001895 Walker B motif; other site 1261131001896 arginine finger; other site 1261131001897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1261131001898 Walker A motif; other site 1261131001899 ATP binding site [chemical binding]; other site 1261131001900 Walker B motif; other site 1261131001901 arginine finger; other site 1261131001902 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1261131001903 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 1261131001904 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1261131001905 trimer interface [polypeptide binding]; other site 1261131001906 active site 1261131001907 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1261131001908 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1261131001909 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1261131001910 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1261131001911 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1261131001912 dihydropteroate synthase; Region: DHPS; TIGR01496 1261131001913 substrate binding pocket [chemical binding]; other site 1261131001914 dimer interface [polypeptide binding]; other site 1261131001915 inhibitor binding site; inhibition site 1261131001916 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 1261131001917 active site 1261131001918 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1261131001919 catalytic center binding site [active] 1261131001920 ATP binding site [chemical binding]; other site 1261131001921 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1261131001922 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1261131001923 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1261131001924 LabA_like proteins; Region: LabA; cd10911 1261131001925 putative metal binding site [ion binding]; other site 1261131001926 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1261131001927 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 1261131001928 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1261131001929 active site 1261131001930 ADP/pyrophosphate binding site [chemical binding]; other site 1261131001931 allosteric effector site; other site 1261131001932 dimerization interface [polypeptide binding]; other site 1261131001933 fructose-1,6-bisphosphate binding site; other site 1261131001934 NAD synthetase; Provisional; Region: PRK13981 1261131001935 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1261131001936 multimer interface [polypeptide binding]; other site 1261131001937 active site 1261131001938 catalytic triad [active] 1261131001939 protein interface 1 [polypeptide binding]; other site 1261131001940 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1261131001941 homodimer interface [polypeptide binding]; other site 1261131001942 NAD binding pocket [chemical binding]; other site 1261131001943 ATP binding pocket [chemical binding]; other site 1261131001944 Mg binding site [ion binding]; other site 1261131001945 active-site loop [active] 1261131001946 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1261131001947 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1261131001948 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1261131001949 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1261131001950 active site 1261131001951 dimer interface [polypeptide binding]; other site 1261131001952 motif 1; other site 1261131001953 motif 2; other site 1261131001954 motif 3; other site 1261131001955 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1261131001956 anticodon binding site; other site 1261131001957 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1261131001958 DNA-binding site [nucleotide binding]; DNA binding site 1261131001959 RNA-binding motif; other site 1261131001960 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1261131001961 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1261131001962 generic binding surface II; other site 1261131001963 ssDNA binding site; other site 1261131001964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1261131001965 ATP binding site [chemical binding]; other site 1261131001966 putative Mg++ binding site [ion binding]; other site 1261131001967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1261131001968 nucleotide binding region [chemical binding]; other site 1261131001969 ATP-binding site [chemical binding]; other site 1261131001970 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 1261131001971 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1261131001972 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1261131001973 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1261131001974 ATP binding site [chemical binding]; other site 1261131001975 putative Mg++ binding site [ion binding]; other site 1261131001976 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1261131001977 nucleotide binding region [chemical binding]; other site 1261131001978 ATP-binding site [chemical binding]; other site 1261131001979 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1261131001980 DNA repair protein RecO; Region: reco; TIGR00613 1261131001981 Recombination protein O N terminal; Region: RecO_N; pfam11967 1261131001982 Recombination protein O C terminal; Region: RecO_C; pfam02565 1261131001983 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1261131001984 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1261131001985 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1261131001986 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1261131001987 Cell division protein FtsQ; Region: FtsQ; pfam03799 1261131001988 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1261131001989 Cell division protein FtsA; Region: FtsA; smart00842 1261131001990 Cell division protein FtsA; Region: FtsA; pfam14450 1261131001991 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1261131001992 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1261131001993 nucleotide binding site [chemical binding]; other site 1261131001994 SulA interaction site; other site 1261131001995 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1261131001996 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1261131001997 putative ABC transporter; Region: ycf24; CHL00085 1261131001998 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1261131001999 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1261131002000 Walker A/P-loop; other site 1261131002001 ATP binding site [chemical binding]; other site 1261131002002 Q-loop/lid; other site 1261131002003 ABC transporter signature motif; other site 1261131002004 Walker B; other site 1261131002005 D-loop; other site 1261131002006 H-loop/switch region; other site 1261131002007 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1261131002008 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1261131002009 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1261131002010 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1261131002011 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1261131002012 catalytic residue [active] 1261131002013 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 1261131002014 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1261131002015 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1261131002016 metal ion-dependent adhesion site (MIDAS); other site 1261131002017 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1261131002018 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1261131002019 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1261131002020 catalytic residues [active] 1261131002021 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1261131002022 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1261131002023 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1261131002024 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1261131002025 catalytic residue [active] 1261131002026 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1261131002027 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1261131002028 dimer interface [polypeptide binding]; other site 1261131002029 putative anticodon binding site; other site 1261131002030 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1261131002031 motif 1; other site 1261131002032 active site 1261131002033 motif 2; other site 1261131002034 motif 3; other site 1261131002035 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1261131002036 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1261131002037 HIGH motif; other site 1261131002038 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1261131002039 active site 1261131002040 KMSKS motif; other site 1261131002041 phosphoglucomutase; Region: PLN02307 1261131002042 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1261131002043 active site 1261131002044 substrate binding site [chemical binding]; other site 1261131002045 metal binding site [ion binding]; metal-binding site 1261131002046 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1261131002047 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1261131002048 metal binding site [ion binding]; metal-binding site 1261131002049 active site 1261131002050 I-site; other site 1261131002051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1261131002052 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1261131002053 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1261131002054 FAD binding domain; Region: FAD_binding_4; pfam01565 1261131002055 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1261131002056 pantothenate kinase; Provisional; Region: PRK05439 1261131002057 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1261131002058 ATP-binding site [chemical binding]; other site 1261131002059 CoA-binding site [chemical binding]; other site 1261131002060 Mg2+-binding site [ion binding]; other site 1261131002061 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1261131002062 catalytic residue [active] 1261131002063 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1261131002064 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1261131002065 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1261131002066 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1261131002067 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1261131002068 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1261131002069 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1261131002070 GatB domain; Region: GatB_Yqey; smart00845 1261131002071 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1261131002072 catalytic residues [active] 1261131002073 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1261131002074 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1261131002075 catalytic site [active] 1261131002076 G-X2-G-X-G-K; other site 1261131002077 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1261131002078 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1261131002079 ATP binding site [chemical binding]; other site 1261131002080 putative Mg++ binding site [ion binding]; other site 1261131002081 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1261131002082 nucleotide binding region [chemical binding]; other site 1261131002083 ATP-binding site [chemical binding]; other site 1261131002084 VRR-NUC domain; Region: VRR_NUC; pfam08774 1261131002085 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1261131002086 active site 1261131002087 substrate binding site [chemical binding]; other site 1261131002088 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1261131002089 active site 1261131002090 DNA binding site [nucleotide binding] 1261131002091 catalytic site [active] 1261131002092 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1261131002093 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1261131002094 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250 1261131002095 nucleotide binding site [chemical binding]; other site 1261131002096 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 1261131002097 Phage associated DNA primase [General function prediction only]; Region: COG3378 1261131002098 D5 N terminal like; Region: D5_N; smart00885 1261131002099 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1261131002100 putative trimer interface [polypeptide binding]; other site 1261131002101 putative CoA binding site [chemical binding]; other site 1261131002102 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1261131002103 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1261131002104 Prophage antirepressor [Transcription]; Region: COG3617 1261131002105 BRO family, N-terminal domain; Region: Bro-N; smart01040 1261131002106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1261131002107 non-specific DNA binding site [nucleotide binding]; other site 1261131002108 salt bridge; other site 1261131002109 sequence-specific DNA binding site [nucleotide binding]; other site 1261131002110 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1261131002111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1261131002112 non-specific DNA binding site [nucleotide binding]; other site 1261131002113 salt bridge; other site 1261131002114 sequence-specific DNA binding site [nucleotide binding]; other site 1261131002115 Terminase-like family; Region: Terminase_6; pfam03237 1261131002116 hypothetical protein; Region: PHA00670 1261131002117 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 1261131002118 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 1261131002119 hypothetical protein; Region: PHA00662 1261131002120 hypothetical protein; Region: PHA00661 1261131002121 structural protein; Region: PHA01972 1261131002122 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1261131002123 Guanylate kinase; Region: Guanylate_kin; pfam00625 1261131002124 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1261131002125 catalytic site [active] 1261131002126 G-X2-G-X-G-K; other site 1261131002127 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1261131002128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1261131002129 ATP binding site [chemical binding]; other site 1261131002130 putative Mg++ binding site [ion binding]; other site 1261131002131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1261131002132 nucleotide binding region [chemical binding]; other site 1261131002133 ATP-binding site [chemical binding]; other site 1261131002134 VRR-NUC domain; Region: VRR_NUC; pfam08774 1261131002135 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1261131002136 active site 1261131002137 substrate binding site [chemical binding]; other site 1261131002138 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1261131002139 active site 1261131002140 DNA binding site [nucleotide binding] 1261131002141 catalytic site [active] 1261131002142 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1261131002143 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1261131002144 hypothetical protein; Region: PHA00661 1261131002145 structural protein; Region: PHA01972 1261131002146 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 1261131002147 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1261131002148 ligand binding site [chemical binding]; other site 1261131002149 active site 1261131002150 UGI interface [polypeptide binding]; other site 1261131002151 catalytic site [active] 1261131002152 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1261131002153 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1261131002154 FeS/SAM binding site; other site 1261131002155 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1261131002156 Thiamine pyrophosphokinase; Region: TPK; cd07995 1261131002157 active site 1261131002158 dimerization interface [polypeptide binding]; other site 1261131002159 thiamine binding site [chemical binding]; other site 1261131002160 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1261131002161 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1261131002162 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1261131002163 elongation factor P; Validated; Region: PRK00529 1261131002164 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1261131002165 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1261131002166 RNA binding site [nucleotide binding]; other site 1261131002167 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1261131002168 RNA binding site [nucleotide binding]; other site 1261131002169 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 1261131002170 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1261131002171 motif 1; other site 1261131002172 dimer interface [polypeptide binding]; other site 1261131002173 active site 1261131002174 motif 2; other site 1261131002175 motif 3; other site 1261131002176 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1261131002177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1261131002178 FeS/SAM binding site; other site 1261131002179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1261131002180 active site 1261131002181 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1261131002182 active site 1261131002183 substrate binding pocket [chemical binding]; other site 1261131002184 dimer interface [polypeptide binding]; other site 1261131002185 thymidylate kinase; Validated; Region: tmk; PRK00698 1261131002186 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1261131002187 TMP-binding site; other site 1261131002188 ATP-binding site [chemical binding]; other site 1261131002189 DNA polymerase III subunit delta'; Validated; Region: PRK09112 1261131002190 AAA ATPase domain; Region: AAA_16; pfam13191 1261131002191 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1261131002192 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1261131002193 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1261131002194 active site 1261131002195 HIGH motif; other site 1261131002196 KMSKS motif; other site 1261131002197 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1261131002198 tRNA binding surface [nucleotide binding]; other site 1261131002199 anticodon binding site; other site 1261131002200 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1261131002201 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1261131002202 active site 1261131002203 putative hydrolase; Provisional; Region: PRK02113 1261131002204 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1261131002205 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1261131002206 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 1261131002207 homodimer interface [polypeptide binding]; other site 1261131002208 substrate binding pocket [chemical binding]; other site 1261131002209 catalytic residues [active] 1261131002210 NADH/NADPH cofactor binding site [chemical binding]; other site 1261131002211 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1261131002212 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1261131002213 homotetramer interface [polypeptide binding]; other site 1261131002214 FMN binding site [chemical binding]; other site 1261131002215 homodimer contacts [polypeptide binding]; other site 1261131002216 putative active site [active] 1261131002217 putative substrate binding site [chemical binding]; other site 1261131002218 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1261131002219 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1261131002220 dimer interface [polypeptide binding]; other site 1261131002221 active site 1261131002222 mevalonate kinase; Region: mevalon_kin; TIGR00549 1261131002223 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1261131002224 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1261131002225 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1261131002226 diphosphomevalonate decarboxylase; Region: PLN02407 1261131002227 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1261131002228 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1261131002229 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1261131002230 Catalytic site [active] 1261131002231 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1261131002232 ribonuclease III; Reviewed; Region: PRK12371 1261131002233 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1261131002234 dimerization interface [polypeptide binding]; other site 1261131002235 active site 1261131002236 metal binding site [ion binding]; metal-binding site 1261131002237 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1261131002238 dsRNA binding site [nucleotide binding]; other site 1261131002239 GTPase Era; Reviewed; Region: era; PRK00089 1261131002240 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1261131002241 G1 box; other site 1261131002242 GTP/Mg2+ binding site [chemical binding]; other site 1261131002243 Switch I region; other site 1261131002244 G2 box; other site 1261131002245 Switch II region; other site 1261131002246 G3 box; other site 1261131002247 G4 box; other site 1261131002248 G5 box; other site 1261131002249 KH domain; Region: KH_2; pfam07650 1261131002250 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 1261131002251 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1261131002252 Substrate binding site; other site 1261131002253 Mg++ binding site; other site 1261131002254 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1261131002255 active site 1261131002256 substrate binding site [chemical binding]; other site 1261131002257 CoA binding site [chemical binding]; other site 1261131002258 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1261131002259 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1261131002260 glutaminase active site [active] 1261131002261 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1261131002262 dimer interface [polypeptide binding]; other site 1261131002263 active site 1261131002264 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1261131002265 dimer interface [polypeptide binding]; other site 1261131002266 active site 1261131002267 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1261131002268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 1261131002269 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1261131002270 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1261131002271 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1261131002272 FMN binding site [chemical binding]; other site 1261131002273 active site 1261131002274 catalytic residues [active] 1261131002275 substrate binding site [chemical binding]; other site 1261131002276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 1261131002277 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1261131002278 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1261131002279 dimerization interface [polypeptide binding]; other site 1261131002280 active site 1261131002281 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1261131002282 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1261131002283 folate binding site [chemical binding]; other site 1261131002284 NADP+ binding site [chemical binding]; other site 1261131002285 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1261131002286 HflK protein; Region: hflK; TIGR01933 1261131002287 HflC protein; Region: hflC; TIGR01932 1261131002288 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1261131002289 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1261131002290 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1261131002291 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1261131002292 metal ion-dependent adhesion site (MIDAS); other site 1261131002293 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1261131002294 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1261131002295 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1261131002296 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 1261131002297 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1261131002298 Flavoprotein; Region: Flavoprotein; pfam02441 1261131002299 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1261131002300 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1261131002301 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1261131002302 putative active site [active] 1261131002303 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1261131002304 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1261131002305 active site 1261131002306 HIGH motif; other site 1261131002307 dimer interface [polypeptide binding]; other site 1261131002308 KMSKS motif; other site 1261131002309 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1261131002310 RNA binding surface [nucleotide binding]; other site 1261131002311 glutathione reductase; Validated; Region: PRK06116 1261131002312 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1261131002313 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1261131002314 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1261131002315 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1261131002316 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1261131002317 active site 1261131002318 dimer interface [polypeptide binding]; other site 1261131002319 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1261131002320 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1261131002321 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1261131002322 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1261131002323 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1261131002324 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1261131002325 E3 interaction surface; other site 1261131002326 lipoyl attachment site [posttranslational modification]; other site 1261131002327 e3 binding domain; Region: E3_binding; pfam02817 1261131002328 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1261131002329 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1261131002330 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1261131002331 TPP-binding site [chemical binding]; other site 1261131002332 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1261131002333 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1261131002334 CoA binding domain; Region: CoA_binding; smart00881 1261131002335 CoA-ligase; Region: Ligase_CoA; pfam00549 1261131002336 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1261131002337 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1261131002338 CoA-ligase; Region: Ligase_CoA; pfam00549 1261131002339 malate dehydrogenase; Reviewed; Region: PRK06223 1261131002340 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1261131002341 NAD(P) binding site [chemical binding]; other site 1261131002342 dimer interface [polypeptide binding]; other site 1261131002343 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1261131002344 substrate binding site [chemical binding]; other site 1261131002345 Predicted ATPase [General function prediction only]; Region: COG1485 1261131002346 Protease inhibitor Inh; Region: Inh; pfam02974 1261131002347 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1261131002348 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1261131002349 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 1261131002350 L-aspartate oxidase; Provisional; Region: PRK06175 1261131002351 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1261131002352 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 1261131002353 putative SdhC subunit interface [polypeptide binding]; other site 1261131002354 putative proximal heme binding site [chemical binding]; other site 1261131002355 putative Iron-sulfur protein interface [polypeptide binding]; other site 1261131002356 putative proximal quinone binding site; other site 1261131002357 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1261131002358 Iron-sulfur protein interface; other site 1261131002359 proximal quinone binding site [chemical binding]; other site 1261131002360 SdhD (CybS) interface [polypeptide binding]; other site 1261131002361 proximal heme binding site [chemical binding]; other site 1261131002362 EVE domain; Region: EVE; cl00728 1261131002363 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1261131002364 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1261131002365 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1261131002366 UGMP family protein; Validated; Region: PRK09604 1261131002367 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1261131002368 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1261131002369 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1261131002370 domain interfaces; other site 1261131002371 active site 1261131002372 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1261131002373 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1261131002374 active site 1261131002375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 1261131002376 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 1261131002377 HemY protein N-terminus; Region: HemY_N; pfam07219 1261131002378 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1261131002379 active site 1261131002380 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1261131002381 Ligand Binding Site [chemical binding]; other site 1261131002382 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1261131002383 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1261131002384 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1261131002385 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1261131002386 nucleotide binding pocket [chemical binding]; other site 1261131002387 K-X-D-G motif; other site 1261131002388 catalytic site [active] 1261131002389 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1261131002390 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1261131002391 Dimer interface [polypeptide binding]; other site 1261131002392 BRCT sequence motif; other site 1261131002393 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1261131002394 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1261131002395 Walker A/P-loop; other site 1261131002396 ATP binding site [chemical binding]; other site 1261131002397 Q-loop/lid; other site 1261131002398 ABC transporter signature motif; other site 1261131002399 Walker B; other site 1261131002400 D-loop; other site 1261131002401 H-loop/switch region; other site 1261131002402 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1261131002403 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1261131002404 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1261131002405 Walker A/P-loop; other site 1261131002406 ATP binding site [chemical binding]; other site 1261131002407 Q-loop/lid; other site 1261131002408 ABC transporter signature motif; other site 1261131002409 Walker B; other site 1261131002410 D-loop; other site 1261131002411 H-loop/switch region; other site 1261131002412 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1261131002413 dipeptide transporter; Provisional; Region: PRK10913 1261131002414 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1261131002415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1261131002416 dimer interface [polypeptide binding]; other site 1261131002417 conserved gate region; other site 1261131002418 putative PBP binding loops; other site 1261131002419 ABC-ATPase subunit interface; other site 1261131002420 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1261131002421 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1261131002422 Walker A/P-loop; other site 1261131002423 ATP binding site [chemical binding]; other site 1261131002424 Q-loop/lid; other site 1261131002425 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1261131002426 ABC transporter signature motif; other site 1261131002427 Walker B; other site 1261131002428 D-loop; other site 1261131002429 H-loop/switch region; other site 1261131002430 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1261131002431 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1261131002432 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1261131002433 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1261131002434 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1261131002435 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1261131002436 hexamer interface [polypeptide binding]; other site 1261131002437 metal binding site [ion binding]; metal-binding site 1261131002438 substrate binding site [chemical binding]; other site 1261131002439 adenylosuccinate lyase; Provisional; Region: PRK07492 1261131002440 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1261131002441 tetramer interface [polypeptide binding]; other site 1261131002442 active site 1261131002443 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1261131002444 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 1261131002445 ATP binding site [chemical binding]; other site 1261131002446 active site 1261131002447 substrate binding site [chemical binding]; other site 1261131002448 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1261131002449 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1261131002450 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1261131002451 putative active site [active] 1261131002452 catalytic triad [active] 1261131002453 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1261131002454 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1261131002455 dimerization interface [polypeptide binding]; other site 1261131002456 ATP binding site [chemical binding]; other site 1261131002457 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1261131002458 dimerization interface [polypeptide binding]; other site 1261131002459 ATP binding site [chemical binding]; other site 1261131002460 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1261131002461 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1261131002462 putative GSH binding site [chemical binding]; other site 1261131002463 catalytic residues [active] 1261131002464 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1261131002465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1261131002466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1261131002467 Coenzyme A binding pocket [chemical binding]; other site 1261131002468 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1261131002469 SurA N-terminal domain; Region: SurA_N_3; cl07813 1261131002470 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1261131002471 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1261131002472 RNA methyltransferase, RsmE family; Region: TIGR00046 1261131002473 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 1261131002474 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1261131002475 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1261131002476 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1261131002477 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 1261131002478 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1261131002479 NAD binding site [chemical binding]; other site 1261131002480 homotetramer interface [polypeptide binding]; other site 1261131002481 homodimer interface [polypeptide binding]; other site 1261131002482 substrate binding site [chemical binding]; other site 1261131002483 active site 1261131002484 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1261131002485 Fe-S metabolism associated domain; Region: SufE; cl00951 1261131002486 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1261131002487 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1261131002488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1261131002489 Walker A motif; other site 1261131002490 ATP binding site [chemical binding]; other site 1261131002491 Walker B motif; other site 1261131002492 arginine finger; other site 1261131002493 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1261131002494 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1261131002495 RuvA N terminal domain; Region: RuvA_N; pfam01330 1261131002496 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1261131002497 active site 1261131002498 putative DNA-binding cleft [nucleotide binding]; other site 1261131002499 dimer interface [polypeptide binding]; other site 1261131002500 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1261131002501 glutaminase; Provisional; Region: PRK00971 1261131002502 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1261131002503 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1261131002504 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1261131002505 RNA binding surface [nucleotide binding]; other site 1261131002506 glutamate racemase; Provisional; Region: PRK00865 1261131002507 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1261131002508 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1261131002509 PAS fold; Region: PAS_3; pfam08447 1261131002510 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1261131002511 PAS fold; Region: PAS_7; pfam12860 1261131002512 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1261131002513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1261131002514 dimer interface [polypeptide binding]; other site 1261131002515 phosphorylation site [posttranslational modification] 1261131002516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1261131002517 ATP binding site [chemical binding]; other site 1261131002518 Mg2+ binding site [ion binding]; other site 1261131002519 G-X-G motif; other site 1261131002520 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 1261131002521 isocitrate dehydrogenase; Validated; Region: PRK08299 1261131002522 CTP synthetase; Validated; Region: pyrG; PRK05380 1261131002523 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1261131002524 Catalytic site [active] 1261131002525 active site 1261131002526 UTP binding site [chemical binding]; other site 1261131002527 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1261131002528 active site 1261131002529 putative oxyanion hole; other site 1261131002530 catalytic triad [active] 1261131002531 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1261131002532 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1261131002533 triosephosphate isomerase; Provisional; Region: PRK14565 1261131002534 substrate binding site [chemical binding]; other site 1261131002535 dimer interface [polypeptide binding]; other site 1261131002536 catalytic triad [active] 1261131002537 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1261131002538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1261131002539 ATP binding site [chemical binding]; other site 1261131002540 Mg2+ binding site [ion binding]; other site 1261131002541 G-X-G motif; other site 1261131002542 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1261131002543 anchoring element; other site 1261131002544 dimer interface [polypeptide binding]; other site 1261131002545 ATP binding site [chemical binding]; other site 1261131002546 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1261131002547 active site 1261131002548 metal binding site [ion binding]; metal-binding site 1261131002549 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1261131002550 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1261131002551 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1261131002552 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1261131002553 active site 1261131002554 NTP binding site [chemical binding]; other site 1261131002555 metal binding triad [ion binding]; metal-binding site 1261131002556 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1261131002557 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 1261131002558 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 1261131002559 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1261131002560 metal ion-dependent adhesion site (MIDAS); other site 1261131002561 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1261131002562 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1261131002563 substrate binding pocket [chemical binding]; other site 1261131002564 chain length determination region; other site 1261131002565 substrate-Mg2+ binding site; other site 1261131002566 catalytic residues [active] 1261131002567 aspartate-rich region 1; other site 1261131002568 active site lid residues [active] 1261131002569 aspartate-rich region 2; other site 1261131002570 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1261131002571 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1261131002572 substrate binding pocket [chemical binding]; other site 1261131002573 membrane-bound complex binding site; other site 1261131002574 hinge residues; other site 1261131002575 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1261131002576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1261131002577 dimer interface [polypeptide binding]; other site 1261131002578 conserved gate region; other site 1261131002579 putative PBP binding loops; other site 1261131002580 ABC-ATPase subunit interface; other site 1261131002581 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1261131002582 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1261131002583 putative active site [active] 1261131002584 catalytic residue [active] 1261131002585 GTP-binding protein YchF; Reviewed; Region: PRK09601 1261131002586 YchF GTPase; Region: YchF; cd01900 1261131002587 G1 box; other site 1261131002588 GTP/Mg2+ binding site [chemical binding]; other site 1261131002589 Switch I region; other site 1261131002590 G2 box; other site 1261131002591 Switch II region; other site 1261131002592 G3 box; other site 1261131002593 G4 box; other site 1261131002594 G5 box; other site 1261131002595 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 1261131002596 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1261131002597 Part of AAA domain; Region: AAA_19; pfam13245 1261131002598 Family description; Region: UvrD_C_2; pfam13538 1261131002599 excinuclease ABC subunit B; Provisional; Region: PRK05298 1261131002600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1261131002601 ATP binding site [chemical binding]; other site 1261131002602 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1261131002603 nucleotide binding region [chemical binding]; other site 1261131002604 ATP-binding site [chemical binding]; other site 1261131002605 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1261131002606 UvrB/uvrC motif; Region: UVR; pfam02151 1261131002607 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1261131002608 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1261131002609 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1261131002610 metal ion-dependent adhesion site (MIDAS); other site 1261131002611 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1261131002612 metal ion-dependent adhesion site (MIDAS); other site 1261131002613 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1261131002614 DNA photolyase; Region: DNA_photolyase; pfam00875 1261131002615 hypothetical protein; Provisional; Region: PRK14013 1261131002616 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1261131002617 Domain of unknown function DUF59; Region: DUF59; pfam01883 1261131002618 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1261131002619 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1261131002620 Walker A motif; other site 1261131002621 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1261131002622 ATP binding site [chemical binding]; other site 1261131002623 active site 1261131002624 substrate binding site [chemical binding]; other site 1261131002625 DNA polymerase I; Provisional; Region: PRK05755 1261131002626 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1261131002627 active site 1261131002628 metal binding site 1 [ion binding]; metal-binding site 1261131002629 putative 5' ssDNA interaction site; other site 1261131002630 metal binding site 3; metal-binding site 1261131002631 metal binding site 2 [ion binding]; metal-binding site 1261131002632 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1261131002633 putative DNA binding site [nucleotide binding]; other site 1261131002634 putative metal binding site [ion binding]; other site 1261131002635 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1261131002636 active site 1261131002637 catalytic site [active] 1261131002638 substrate binding site [chemical binding]; other site 1261131002639 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1261131002640 active site 1261131002641 DNA binding site [nucleotide binding] 1261131002642 catalytic site [active] 1261131002643 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1261131002644 catalytic core [active] 1261131002645 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1261131002646 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1261131002647 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1261131002648 glucokinase; Provisional; Region: glk; PRK00292 1261131002649 glucokinase, proteobacterial type; Region: glk; TIGR00749 1261131002650 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1261131002651 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1261131002652 Cu(I) binding site [ion binding]; other site 1261131002653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1261131002654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1261131002655 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1261131002656 putative effector binding pocket; other site 1261131002657 dimerization interface [polypeptide binding]; other site 1261131002658 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1261131002659 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1261131002660 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1261131002661 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1261131002662 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1261131002663 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1261131002664 active site 1261131002665 HIGH motif; other site 1261131002666 KMSK motif region; other site 1261131002667 tRNA binding surface [nucleotide binding]; other site 1261131002668 DALR anticodon binding domain; Region: DALR_1; smart00836 1261131002669 anticodon binding site; other site 1261131002670 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1261131002671 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1261131002672 Zn2+ binding site [ion binding]; other site 1261131002673 Mg2+ binding site [ion binding]; other site 1261131002674 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1261131002675 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1261131002676 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1261131002677 putative catalytic site [active] 1261131002678 putative phosphate binding site [ion binding]; other site 1261131002679 active site 1261131002680 metal binding site A [ion binding]; metal-binding site 1261131002681 DNA binding site [nucleotide binding] 1261131002682 putative AP binding site [nucleotide binding]; other site 1261131002683 putative metal binding site B [ion binding]; other site 1261131002684 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1261131002685 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1261131002686 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1261131002687 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1261131002688 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1261131002689 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1261131002690 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1261131002691 DNA binding residues [nucleotide binding] 1261131002692 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1261131002693 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1261131002694 NAD(P) binding site [chemical binding]; other site 1261131002695 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1261131002696 23S rRNA interface [nucleotide binding]; other site 1261131002697 L3 interface [polypeptide binding]; other site 1261131002698 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1261131002699 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 1261131002700 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1261131002701 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1261131002702 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1261131002703 dimerization interface 3.5A [polypeptide binding]; other site 1261131002704 active site 1261131002705 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1261131002706 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1261131002707 putative active site [active] 1261131002708 substrate binding site [chemical binding]; other site 1261131002709 putative cosubstrate binding site; other site 1261131002710 catalytic site [active] 1261131002711 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1261131002712 substrate binding site [chemical binding]; other site 1261131002713 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1261131002714 active site 1261131002715 catalytic residues [active] 1261131002716 metal binding site [ion binding]; metal-binding site 1261131002717 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1261131002718 YceG-like family; Region: YceG; pfam02618 1261131002719 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1261131002720 dimerization interface [polypeptide binding]; other site 1261131002721 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1261131002722 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1261131002723 dimer interface [polypeptide binding]; other site 1261131002724 active site 1261131002725 acyl carrier protein; Provisional; Region: acpP; PRK00982 1261131002726 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 1261131002727 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1261131002728 NAD(P) binding site [chemical binding]; other site 1261131002729 homotetramer interface [polypeptide binding]; other site 1261131002730 homodimer interface [polypeptide binding]; other site 1261131002731 active site 1261131002732 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1261131002733 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1261131002734 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1261131002735 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1261131002736 metal binding site [ion binding]; metal-binding site 1261131002737 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1261131002738 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1261131002739 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1261131002740 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1261131002741 ABC-ATPase subunit interface; other site 1261131002742 dimer interface [polypeptide binding]; other site 1261131002743 putative PBP binding regions; other site 1261131002744 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1261131002745 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1261131002746 ABC-ATPase subunit interface; other site 1261131002747 dimer interface [polypeptide binding]; other site 1261131002748 putative PBP binding regions; other site 1261131002749 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970 1261131002750 NADH dehydrogenase; Validated; Region: PRK08183 1261131002751 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 1261131002752 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1261131002753 active site 1261131002754 substrate binding site [chemical binding]; other site 1261131002755 metal binding site [ion binding]; metal-binding site 1261131002756 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1261131002757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1261131002758 Walker A motif; other site 1261131002759 ATP binding site [chemical binding]; other site 1261131002760 Walker B motif; other site 1261131002761 arginine finger; other site 1261131002762 Peptidase family M41; Region: Peptidase_M41; pfam01434 1261131002763 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1261131002764 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1261131002765 Ligand Binding Site [chemical binding]; other site 1261131002766 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1261131002767 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1261131002768 ligand binding site [chemical binding]; other site 1261131002769 translocation protein TolB; Provisional; Region: tolB; PRK05137 1261131002770 TolB amino-terminal domain; Region: TolB_N; pfam04052 1261131002771 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1261131002772 glutamine synthetase, type I; Region: GlnA; TIGR00653 1261131002773 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1261131002774 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1261131002775 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1261131002776 AAA domain; Region: AAA_11; pfam13086 1261131002777 Part of AAA domain; Region: AAA_19; pfam13245 1261131002778 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1261131002779 AAA domain; Region: AAA_12; pfam13087 1261131002780 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1261131002781 putative active site [active] 1261131002782 YGGT family; Region: YGGT; cl00508 1261131002783 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 1261131002784 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1261131002785 dimer interface [polypeptide binding]; other site 1261131002786 substrate binding site [chemical binding]; other site 1261131002787 metal binding sites [ion binding]; metal-binding site 1261131002788 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1261131002789 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1261131002790 G1 box; other site 1261131002791 putative GEF interaction site [polypeptide binding]; other site 1261131002792 GTP/Mg2+ binding site [chemical binding]; other site 1261131002793 Switch I region; other site 1261131002794 G2 box; other site 1261131002795 G3 box; other site 1261131002796 Switch II region; other site 1261131002797 G4 box; other site 1261131002798 G5 box; other site 1261131002799 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1261131002800 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1261131002801 argininosuccinate synthase; Provisional; Region: PRK13820 1261131002802 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1261131002803 ANP binding site [chemical binding]; other site 1261131002804 Substrate Binding Site II [chemical binding]; other site 1261131002805 Substrate Binding Site I [chemical binding]; other site 1261131002806 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1261131002807 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1261131002808 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1261131002809 alphaNTD - beta interaction site [polypeptide binding]; other site 1261131002810 alphaNTD homodimer interface [polypeptide binding]; other site 1261131002811 alphaNTD - beta' interaction site [polypeptide binding]; other site 1261131002812 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1261131002813 30S ribosomal protein S11; Validated; Region: PRK05309 1261131002814 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1261131002815 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1261131002816 adenylate kinase; Reviewed; Region: adk; PRK00279 1261131002817 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1261131002818 AMP-binding site [chemical binding]; other site 1261131002819 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1261131002820 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1261131002821 SecY translocase; Region: SecY; pfam00344 1261131002822 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1261131002823 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1261131002824 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1261131002825 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1261131002826 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1261131002827 23S rRNA interface [nucleotide binding]; other site 1261131002828 L21e interface [polypeptide binding]; other site 1261131002829 5S rRNA interface [nucleotide binding]; other site 1261131002830 L27 interface [polypeptide binding]; other site 1261131002831 L5 interface [polypeptide binding]; other site 1261131002832 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1261131002833 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1261131002834 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1261131002835 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1261131002836 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1261131002837 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1261131002838 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1261131002839 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1261131002840 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1261131002841 RNA binding site [nucleotide binding]; other site 1261131002842 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1261131002843 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1261131002844 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1261131002845 23S rRNA interface [nucleotide binding]; other site 1261131002846 putative translocon interaction site; other site 1261131002847 signal recognition particle (SRP54) interaction site; other site 1261131002848 L23 interface [polypeptide binding]; other site 1261131002849 trigger factor interaction site; other site 1261131002850 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1261131002851 23S rRNA interface [nucleotide binding]; other site 1261131002852 5S rRNA interface [nucleotide binding]; other site 1261131002853 putative antibiotic binding site [chemical binding]; other site 1261131002854 L25 interface [polypeptide binding]; other site 1261131002855 L27 interface [polypeptide binding]; other site 1261131002856 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 1261131002857 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1261131002858 G-X-X-G motif; other site 1261131002859 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1261131002860 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1261131002861 putative translocon binding site; other site 1261131002862 protein-rRNA interface [nucleotide binding]; other site 1261131002863 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1261131002864 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1261131002865 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1261131002866 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1261131002867 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1261131002868 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1261131002869 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1261131002870 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1261131002871 elongation factor Tu; Reviewed; Region: PRK00049 1261131002872 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1261131002873 G1 box; other site 1261131002874 GEF interaction site [polypeptide binding]; other site 1261131002875 GTP/Mg2+ binding site [chemical binding]; other site 1261131002876 Switch I region; other site 1261131002877 G2 box; other site 1261131002878 G3 box; other site 1261131002879 Switch II region; other site 1261131002880 G4 box; other site 1261131002881 G5 box; other site 1261131002882 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1261131002883 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1261131002884 Antibiotic Binding Site [chemical binding]; other site 1261131002885 elongation factor G; Reviewed; Region: PRK00007 1261131002886 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1261131002887 G1 box; other site 1261131002888 putative GEF interaction site [polypeptide binding]; other site 1261131002889 GTP/Mg2+ binding site [chemical binding]; other site 1261131002890 Switch I region; other site 1261131002891 G2 box; other site 1261131002892 G3 box; other site 1261131002893 Switch II region; other site 1261131002894 G4 box; other site 1261131002895 G5 box; other site 1261131002896 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1261131002897 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1261131002898 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1261131002899 30S ribosomal protein S7; Validated; Region: PRK05302 1261131002900 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1261131002901 S17 interaction site [polypeptide binding]; other site 1261131002902 S8 interaction site; other site 1261131002903 16S rRNA interaction site [nucleotide binding]; other site 1261131002904 streptomycin interaction site [chemical binding]; other site 1261131002905 23S rRNA interaction site [nucleotide binding]; other site 1261131002906 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1261131002907 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1261131002908 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1261131002909 carboxyltransferase (CT) interaction site; other site 1261131002910 biotinylation site [posttranslational modification]; other site 1261131002911 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1261131002912 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1261131002913 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1261131002914 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1261131002915 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1261131002916 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1261131002917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1261131002918 Walker A motif; other site 1261131002919 ATP binding site [chemical binding]; other site 1261131002920 Walker B motif; other site 1261131002921 arginine finger; other site 1261131002922 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1261131002923 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1261131002924 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1261131002925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1261131002926 Walker A motif; other site 1261131002927 ATP binding site [chemical binding]; other site 1261131002928 Walker B motif; other site 1261131002929 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1261131002930 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1261131002931 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1261131002932 oligomer interface [polypeptide binding]; other site 1261131002933 active site residues [active] 1261131002934 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1261131002935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1261131002936 Walker A/P-loop; other site 1261131002937 ATP binding site [chemical binding]; other site 1261131002938 Q-loop/lid; other site 1261131002939 ABC transporter signature motif; other site 1261131002940 Walker B; other site 1261131002941 D-loop; other site 1261131002942 H-loop/switch region; other site 1261131002943 ABC transporter; Region: ABC_tran_2; pfam12848 1261131002944 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1261131002945 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1261131002946 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1261131002947 SmpB-tmRNA interface; other site 1261131002948 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1261131002949 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1261131002950 dimer interface [polypeptide binding]; other site 1261131002951 active site 1261131002952 catalytic residue [active] 1261131002953 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1261131002954 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1261131002955 motif 1; other site 1261131002956 dimer interface [polypeptide binding]; other site 1261131002957 active site 1261131002958 motif 2; other site 1261131002959 motif 3; other site 1261131002960 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1261131002961 anticodon binding site; other site 1261131002962 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1261131002963 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1261131002964 hinge; other site 1261131002965 active site 1261131002966 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 1261131002967 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1261131002968 Protein export membrane protein; Region: SecD_SecF; pfam02355 1261131002969 putative cation:proton antiport protein; Provisional; Region: PRK10669 1261131002970 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1261131002971 TrkA-N domain; Region: TrkA_N; pfam02254 1261131002972 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1261131002973 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1261131002974 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1261131002975 putative active site [active] 1261131002976 putative substrate binding site [chemical binding]; other site 1261131002977 putative cosubstrate binding site; other site 1261131002978 catalytic site [active] 1261131002979 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1261131002980 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1261131002981 catalytic site [active] 1261131002982 G-X2-G-X-G-K; other site 1261131002983 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1261131002984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1261131002985 active site 1261131002986 phosphorylation site [posttranslational modification] 1261131002987 intermolecular recognition site; other site 1261131002988 dimerization interface [polypeptide binding]; other site 1261131002989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1261131002990 Walker A motif; other site 1261131002991 ATP binding site [chemical binding]; other site 1261131002992 Walker B motif; other site 1261131002993 arginine finger; other site 1261131002994 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1261131002995 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1261131002996 substrate binding pocket [chemical binding]; other site 1261131002997 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1261131002998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1261131002999 Walker A motif; other site 1261131003000 ATP binding site [chemical binding]; other site 1261131003001 Walker B motif; other site 1261131003002 arginine finger; other site 1261131003003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1261131003004 Walker A motif; other site 1261131003005 ATP binding site [chemical binding]; other site 1261131003006 Walker B motif; other site 1261131003007 arginine finger; other site 1261131003008 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1261131003009 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1261131003010 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 1261131003011 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1261131003012 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1261131003013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 1261131003014 salicylate hydroxylase; Provisional; Region: PRK08163 1261131003015 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1261131003016 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1261131003017 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1261131003018 substrate binding pocket [chemical binding]; other site 1261131003019 membrane-bound complex binding site; other site 1261131003020 hinge residues; other site 1261131003021 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1261131003022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1261131003023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1261131003024 dimer interface [polypeptide binding]; other site 1261131003025 conserved gate region; other site 1261131003026 putative PBP binding loops; other site 1261131003027 ABC-ATPase subunit interface; other site 1261131003028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1261131003029 dimer interface [polypeptide binding]; other site 1261131003030 conserved gate region; other site 1261131003031 putative PBP binding loops; other site 1261131003032 ABC-ATPase subunit interface; other site 1261131003033 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1261131003034 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1261131003035 Walker A/P-loop; other site 1261131003036 ATP binding site [chemical binding]; other site 1261131003037 Q-loop/lid; other site 1261131003038 ABC transporter signature motif; other site 1261131003039 Walker B; other site 1261131003040 D-loop; other site 1261131003041 H-loop/switch region; other site 1261131003042 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 1261131003043 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1261131003044 NodB motif; other site 1261131003045 putative active site [active] 1261131003046 putative catalytic site [active] 1261131003047 Zn binding site [ion binding]; other site 1261131003048 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1261131003049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1261131003050 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1261131003051 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1261131003052 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1261131003053 dimerization interface [polypeptide binding]; other site 1261131003054 putative ATP binding site [chemical binding]; other site 1261131003055 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1261131003056 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1261131003057 active site 1261131003058 substrate binding site [chemical binding]; other site 1261131003059 cosubstrate binding site; other site 1261131003060 catalytic site [active] 1261131003061 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1261131003062 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1261131003063 TadE-like protein; Region: TadE; pfam07811 1261131003064 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1261131003065 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1261131003066 active site 1261131003067 HIGH motif; other site 1261131003068 nucleotide binding site [chemical binding]; other site 1261131003069 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1261131003070 KMSKS motif; other site 1261131003071 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1261131003072 rarD protein; Region: rarD; TIGR00688 1261131003073 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1261131003074 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1261131003075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1261131003076 Walker A/P-loop; other site 1261131003077 ATP binding site [chemical binding]; other site 1261131003078 Q-loop/lid; other site 1261131003079 ABC transporter signature motif; other site 1261131003080 Walker B; other site 1261131003081 D-loop; other site 1261131003082 H-loop/switch region; other site 1261131003083 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1261131003084 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1261131003085 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1261131003086 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1261131003087 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1261131003088 putative acyl-acceptor binding pocket; other site 1261131003089 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1261131003090 putative active site [active] 1261131003091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1261131003092 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1261131003093 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1261131003094 HSP70 interaction site [polypeptide binding]; other site 1261131003095 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1261131003096 shikimate kinase; Provisional; Region: PRK13946 1261131003097 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1261131003098 ADP binding site [chemical binding]; other site 1261131003099 magnesium binding site [ion binding]; other site 1261131003100 putative shikimate binding site; other site 1261131003101 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1261131003102 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1261131003103 active site 1261131003104 DNA binding site [nucleotide binding] 1261131003105 Int/Topo IB signature motif; other site 1261131003106 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1261131003107 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1261131003108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1261131003109 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1261131003110 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1261131003111 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 1261131003112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1261131003113 binding surface 1261131003114 TPR motif; other site 1261131003115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1261131003116 TPR motif; other site 1261131003117 binding surface 1261131003118 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1261131003119 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1261131003120 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1261131003121 C-terminal domain interface [polypeptide binding]; other site 1261131003122 GSH binding site (G-site) [chemical binding]; other site 1261131003123 dimer interface [polypeptide binding]; other site 1261131003124 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1261131003125 N-terminal domain interface [polypeptide binding]; other site 1261131003126 dimer interface [polypeptide binding]; other site 1261131003127 substrate binding pocket (H-site) [chemical binding]; other site 1261131003128 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1261131003129 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1261131003130 putative NAD(P) binding site [chemical binding]; other site 1261131003131 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1261131003132 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1261131003133 Walker A/P-loop; other site 1261131003134 ATP binding site [chemical binding]; other site 1261131003135 Q-loop/lid; other site 1261131003136 ABC transporter signature motif; other site 1261131003137 Walker B; other site 1261131003138 D-loop; other site 1261131003139 H-loop/switch region; other site 1261131003140 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1261131003141 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1261131003142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1261131003143 dimer interface [polypeptide binding]; other site 1261131003144 conserved gate region; other site 1261131003145 putative PBP binding loops; other site 1261131003146 ABC-ATPase subunit interface; other site 1261131003147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1261131003148 dimer interface [polypeptide binding]; other site 1261131003149 conserved gate region; other site 1261131003150 putative PBP binding loops; other site 1261131003151 ABC-ATPase subunit interface; other site 1261131003152 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1261131003153 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1261131003154 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1261131003155 GIY-YIG motif/motif A; other site 1261131003156 active site 1261131003157 catalytic site [active] 1261131003158 putative DNA binding site [nucleotide binding]; other site 1261131003159 metal binding site [ion binding]; metal-binding site 1261131003160 UvrB/uvrC motif; Region: UVR; pfam02151 1261131003161 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1261131003162 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1261131003163 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1261131003164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1261131003165 ATP binding site [chemical binding]; other site 1261131003166 putative Mg++ binding site [ion binding]; other site 1261131003167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1261131003168 nucleotide binding region [chemical binding]; other site 1261131003169 ATP-binding site [chemical binding]; other site 1261131003170 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1261131003171 RNA binding site [nucleotide binding]; other site 1261131003172 aspartate aminotransferase; Provisional; Region: PRK05764 1261131003173 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1261131003174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1261131003175 homodimer interface [polypeptide binding]; other site 1261131003176 catalytic residue [active] 1261131003177 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1261131003178 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1261131003179 substrate-cofactor binding pocket; other site 1261131003180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1261131003181 catalytic residue [active] 1261131003182 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1261131003183 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1261131003184 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1261131003185 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1261131003186 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1261131003187 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1261131003188 active site 1261131003189 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1261131003190 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1261131003191 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1261131003192 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1261131003193 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1261131003194 active site 1261131003195 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1261131003196 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1261131003197 active site 1261131003198 metal binding site [ion binding]; metal-binding site 1261131003199 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1261131003200 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1261131003201 RNA binding surface [nucleotide binding]; other site 1261131003202 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1261131003203 active site 1261131003204 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1261131003205 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1261131003206 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1261131003207 DNA binding residues [nucleotide binding] 1261131003208 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1261131003209 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1261131003210 GDP-binding site [chemical binding]; other site 1261131003211 ACT binding site; other site 1261131003212 IMP binding site; other site 1261131003213 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1261131003214 gamma subunit interface [polypeptide binding]; other site 1261131003215 epsilon subunit interface [polypeptide binding]; other site 1261131003216 LBP interface [polypeptide binding]; other site 1261131003217 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1261131003218 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1261131003219 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1261131003220 alpha subunit interaction interface [polypeptide binding]; other site 1261131003221 Walker A motif; other site 1261131003222 ATP binding site [chemical binding]; other site 1261131003223 Walker B motif; other site 1261131003224 inhibitor binding site; inhibition site 1261131003225 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1261131003226 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1261131003227 core domain interface [polypeptide binding]; other site 1261131003228 delta subunit interface [polypeptide binding]; other site 1261131003229 epsilon subunit interface [polypeptide binding]; other site 1261131003230 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1261131003231 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1261131003232 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1261131003233 beta subunit interaction interface [polypeptide binding]; other site 1261131003234 Walker A motif; other site 1261131003235 ATP binding site [chemical binding]; other site 1261131003236 Walker B motif; other site 1261131003237 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1261131003238 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1261131003239 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1261131003240 primosome assembly protein PriA; Validated; Region: PRK05580 1261131003241 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1261131003242 ATP binding site [chemical binding]; other site 1261131003243 putative Mg++ binding site [ion binding]; other site 1261131003244 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1261131003245 nucleotide binding region [chemical binding]; other site 1261131003246 ATP-binding site [chemical binding]; other site 1261131003247 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1261131003248 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1261131003249 putative dimer interface [polypeptide binding]; other site 1261131003250 ABC1 family; Region: ABC1; cl17513 1261131003251 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1261131003252 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1261131003253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1261131003254 S-adenosylmethionine binding site [chemical binding]; other site 1261131003255 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1261131003256 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1261131003257 DNA binding site [nucleotide binding] 1261131003258 catalytic residue [active] 1261131003259 H2TH interface [polypeptide binding]; other site 1261131003260 putative catalytic residues [active] 1261131003261 turnover-facilitating residue; other site 1261131003262 intercalation triad [nucleotide binding]; other site 1261131003263 8OG recognition residue [nucleotide binding]; other site 1261131003264 putative reading head residues; other site 1261131003265 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1261131003266 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1261131003267 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239