-- dump date 20140619_024024 -- class Genbank::misc_feature -- table misc_feature_note -- id note 671143000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 671143000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 671143000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143000004 Walker A motif; other site 671143000005 ATP binding site [chemical binding]; other site 671143000006 Walker B motif; other site 671143000007 arginine finger; other site 671143000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 671143000009 DnaA box-binding interface [nucleotide binding]; other site 671143000010 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 671143000011 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 671143000012 putative NADP binding site [chemical binding]; other site 671143000013 putative substrate binding site [chemical binding]; other site 671143000014 active site 671143000015 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 671143000016 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 671143000017 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 671143000018 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 671143000019 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 671143000020 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 671143000021 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 671143000022 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 671143000023 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 671143000024 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 671143000025 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 671143000026 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 671143000027 protein binding site [polypeptide binding]; other site 671143000028 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 671143000029 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 671143000030 active site 671143000031 dimerization interface [polypeptide binding]; other site 671143000032 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 671143000033 Rubrerythrin [Energy production and conversion]; Region: COG1592 671143000034 iron binding site [ion binding]; other site 671143000035 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 671143000036 Carbon starvation protein CstA; Region: CstA; pfam02554 671143000037 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 671143000038 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 671143000039 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 671143000040 active site 671143000041 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 671143000042 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 671143000043 Ligand Binding Site [chemical binding]; other site 671143000044 Kelch motif; Region: Kelch_1; pfam01344 671143000045 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 671143000046 Kelch domain; Region: Kelch; smart00612 671143000047 Kelch motif; Region: Kelch_1; pfam01344 671143000048 Kelch domain; Region: Kelch; smart00612 671143000049 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 671143000050 toxin interface [polypeptide binding]; other site 671143000051 Zn binding site [ion binding]; other site 671143000052 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 671143000053 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 671143000054 putative active site [active] 671143000055 putative NTP binding site [chemical binding]; other site 671143000056 putative nucleic acid binding site [nucleotide binding]; other site 671143000057 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 671143000058 Methyltransferase domain; Region: Methyltransf_23; pfam13489 671143000059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143000060 S-adenosylmethionine binding site [chemical binding]; other site 671143000061 Transposase; Region: DEDD_Tnp_IS110; pfam01548 671143000062 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 671143000063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143000064 Walker A motif; other site 671143000065 ATP binding site [chemical binding]; other site 671143000066 Walker B motif; other site 671143000067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 671143000068 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 671143000069 putative homodimer interface [polypeptide binding]; other site 671143000070 putative homotetramer interface [polypeptide binding]; other site 671143000071 putative allosteric switch controlling residues; other site 671143000072 putative metal binding site [ion binding]; other site 671143000073 putative homodimer-homodimer interface [polypeptide binding]; other site 671143000074 hypothetical protein; Provisional; Region: PRK07236 671143000075 Uncharacterized conserved protein [Function unknown]; Region: COG3350 671143000076 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 671143000077 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 671143000078 metal-binding site [ion binding] 671143000079 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 671143000080 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 671143000081 metal-binding site [ion binding] 671143000082 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 671143000083 Soluble P-type ATPase [General function prediction only]; Region: COG4087 671143000084 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 671143000085 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 671143000086 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 671143000087 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 671143000088 FtsX-like permease family; Region: FtsX; pfam02687 671143000089 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 671143000090 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 671143000091 FtsX-like permease family; Region: FtsX; pfam02687 671143000092 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 671143000093 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 671143000094 Walker A/P-loop; other site 671143000095 ATP binding site [chemical binding]; other site 671143000096 Q-loop/lid; other site 671143000097 ABC transporter signature motif; other site 671143000098 Walker B; other site 671143000099 D-loop; other site 671143000100 H-loop/switch region; other site 671143000101 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 671143000102 HlyD family secretion protein; Region: HlyD_3; pfam13437 671143000103 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 671143000104 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 671143000105 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 671143000106 Active site cavity [active] 671143000107 catalytic acid [active] 671143000108 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 671143000109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143000110 FeS/SAM binding site; other site 671143000111 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 671143000112 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 671143000113 inhibitor-cofactor binding pocket; inhibition site 671143000114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143000115 catalytic residue [active] 671143000116 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 671143000117 spermidine synthase; Provisional; Region: PRK00811 671143000118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143000119 S-adenosylmethionine binding site [chemical binding]; other site 671143000120 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 671143000121 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 671143000122 homodimer interface [polypeptide binding]; other site 671143000123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143000124 catalytic residue [active] 671143000125 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 671143000126 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 671143000127 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 671143000128 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 671143000129 Protein export membrane protein; Region: SecD_SecF; pfam02355 671143000130 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 671143000131 dimer interface [polypeptide binding]; other site 671143000132 active site 671143000133 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 671143000134 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 671143000135 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 671143000136 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 671143000137 DNA protecting protein DprA; Region: dprA; TIGR00732 671143000138 DNA topoisomerase I; Validated; Region: PRK06599 671143000139 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 671143000140 active site 671143000141 interdomain interaction site; other site 671143000142 putative metal-binding site [ion binding]; other site 671143000143 nucleotide binding site [chemical binding]; other site 671143000144 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 671143000145 domain I; other site 671143000146 DNA binding groove [nucleotide binding] 671143000147 phosphate binding site [ion binding]; other site 671143000148 domain II; other site 671143000149 domain III; other site 671143000150 nucleotide binding site [chemical binding]; other site 671143000151 catalytic site [active] 671143000152 domain IV; other site 671143000153 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 671143000154 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 671143000155 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 671143000156 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 671143000157 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 671143000158 Glucose inhibited division protein A; Region: GIDA; pfam01134 671143000159 PIN domain; Region: PIN_3; pfam13470 671143000160 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 671143000161 Transposase, Mutator family; Region: Transposase_mut; pfam00872 671143000162 SEC-C motif; Region: SEC-C; pfam02810 671143000163 AAA domain; Region: AAA_14; pfam13173 671143000164 AAA domain; Region: AAA_22; pfam13401 671143000165 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 671143000166 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 671143000167 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 671143000168 active site 671143000169 Int/Topo IB signature motif; other site 671143000170 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 671143000171 active site 671143000172 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 671143000173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143000174 Walker A motif; other site 671143000175 ATP binding site [chemical binding]; other site 671143000176 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 671143000177 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 671143000178 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 671143000179 feedback inhibition sensing region; other site 671143000180 homohexameric interface [polypeptide binding]; other site 671143000181 nucleotide binding site [chemical binding]; other site 671143000182 N-acetyl-L-glutamate binding site [chemical binding]; other site 671143000183 acetylornithine aminotransferase; Provisional; Region: PRK02627 671143000184 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 671143000185 inhibitor-cofactor binding pocket; inhibition site 671143000186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143000187 catalytic residue [active] 671143000188 ornithine carbamoyltransferase; Provisional; Region: PRK00779 671143000189 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 671143000190 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 671143000191 Protein of unknown function (DUF433); Region: DUF433; pfam04255 671143000192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 671143000193 AAA domain; Region: AAA_14; pfam13173 671143000194 AAA domain; Region: AAA_22; pfam13401 671143000195 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 671143000196 Nuclease-related domain; Region: NERD; pfam08378 671143000197 hypothetical protein; Reviewed; Region: PRK00024 671143000198 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 671143000199 MPN+ (JAMM) motif; other site 671143000200 Zinc-binding site [ion binding]; other site 671143000201 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 671143000202 active site 671143000203 NTP binding site [chemical binding]; other site 671143000204 metal binding triad [ion binding]; metal-binding site 671143000205 antibiotic binding site [chemical binding]; other site 671143000206 argininosuccinate synthase; Provisional; Region: PRK13820 671143000207 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 671143000208 ANP binding site [chemical binding]; other site 671143000209 Substrate Binding Site II [chemical binding]; other site 671143000210 Substrate Binding Site I [chemical binding]; other site 671143000211 argininosuccinate lyase; Provisional; Region: PRK00855 671143000212 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 671143000213 active sites [active] 671143000214 tetramer interface [polypeptide binding]; other site 671143000215 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 671143000216 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 671143000217 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 671143000218 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 671143000219 G1 box; other site 671143000220 putative GEF interaction site [polypeptide binding]; other site 671143000221 GTP/Mg2+ binding site [chemical binding]; other site 671143000222 Switch I region; other site 671143000223 G2 box; other site 671143000224 G3 box; other site 671143000225 Switch II region; other site 671143000226 G4 box; other site 671143000227 G5 box; other site 671143000228 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 671143000229 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 671143000230 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 671143000231 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 671143000232 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 671143000233 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 671143000234 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 671143000235 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 671143000236 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 671143000237 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 671143000238 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 671143000239 ligand binding site [chemical binding]; other site 671143000240 homodimer interface [polypeptide binding]; other site 671143000241 NAD(P) binding site [chemical binding]; other site 671143000242 trimer interface B [polypeptide binding]; other site 671143000243 trimer interface A [polypeptide binding]; other site 671143000244 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 671143000245 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 671143000246 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 671143000247 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 671143000248 ATP-grasp domain; Region: ATP-grasp_4; cl17255 671143000249 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 671143000250 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 671143000251 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 671143000252 catalytic residue [active] 671143000253 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 671143000254 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 671143000255 N-terminal plug; other site 671143000256 ligand-binding site [chemical binding]; other site 671143000257 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 671143000258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143000259 dimerization interface [polypeptide binding]; other site 671143000260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143000261 dimer interface [polypeptide binding]; other site 671143000262 phosphorylation site [posttranslational modification] 671143000263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143000264 ATP binding site [chemical binding]; other site 671143000265 Mg2+ binding site [ion binding]; other site 671143000266 G-X-G motif; other site 671143000267 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143000268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143000269 active site 671143000270 phosphorylation site [posttranslational modification] 671143000271 intermolecular recognition site; other site 671143000272 dimerization interface [polypeptide binding]; other site 671143000273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143000274 Walker A motif; other site 671143000275 ATP binding site [chemical binding]; other site 671143000276 Walker B motif; other site 671143000277 arginine finger; other site 671143000278 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143000279 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 671143000280 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 671143000281 N-terminal plug; other site 671143000282 ligand-binding site [chemical binding]; other site 671143000283 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143000284 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143000285 dimerization interface [polypeptide binding]; other site 671143000286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143000287 dimer interface [polypeptide binding]; other site 671143000288 phosphorylation site [posttranslational modification] 671143000289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143000290 ATP binding site [chemical binding]; other site 671143000291 Mg2+ binding site [ion binding]; other site 671143000292 G-X-G motif; other site 671143000293 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143000294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143000295 active site 671143000296 phosphorylation site [posttranslational modification] 671143000297 intermolecular recognition site; other site 671143000298 dimerization interface [polypeptide binding]; other site 671143000299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143000300 Walker A motif; other site 671143000301 ATP binding site [chemical binding]; other site 671143000302 Walker B motif; other site 671143000303 arginine finger; other site 671143000304 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143000305 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 671143000306 putative active site [active] 671143000307 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 671143000308 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 671143000309 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 671143000310 Trp docking motif [polypeptide binding]; other site 671143000311 dimer interface [polypeptide binding]; other site 671143000312 active site 671143000313 small subunit binding site [polypeptide binding]; other site 671143000314 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 671143000315 methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870 671143000316 substrate binding pocket [chemical binding]; other site 671143000317 membrane-bound complex binding site; other site 671143000318 hinge residues; other site 671143000319 cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872 671143000320 Methanol dehydrogenase beta subunit; Region: MDH; pfam02315 671143000321 MoxR-like ATPases [General function prediction only]; Region: COG0714 671143000322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143000323 Walker A motif; other site 671143000324 ATP binding site [chemical binding]; other site 671143000325 Walker B motif; other site 671143000326 arginine finger; other site 671143000327 Protein of unknown function DUF58; Region: DUF58; pfam01882 671143000328 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 671143000329 metal ion-dependent adhesion site (MIDAS); other site 671143000330 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 671143000331 metal ion-dependent adhesion site (MIDAS); other site 671143000332 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 671143000333 putative hydrophobic ligand binding site [chemical binding]; other site 671143000334 protein interface [polypeptide binding]; other site 671143000335 gate; other site 671143000336 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 671143000337 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143000338 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143000339 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143000340 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143000341 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 671143000342 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 671143000343 Trp docking motif [polypeptide binding]; other site 671143000344 active site 671143000345 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 671143000346 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 671143000347 substrate binding pocket [chemical binding]; other site 671143000348 membrane-bound complex binding site; other site 671143000349 hinge residues; other site 671143000350 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143000351 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143000352 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 671143000353 Cytochrome c; Region: Cytochrom_C; cl11414 671143000354 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143000355 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 671143000356 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 671143000357 structural tetrad; other site 671143000358 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 671143000359 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 671143000360 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 671143000361 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 671143000362 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 671143000363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 671143000364 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 671143000365 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 671143000366 Trp docking motif [polypeptide binding]; other site 671143000367 dimer interface [polypeptide binding]; other site 671143000368 active site 671143000369 small subunit binding site [polypeptide binding]; other site 671143000370 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 671143000371 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 671143000372 substrate binding pocket [chemical binding]; other site 671143000373 membrane-bound complex binding site; other site 671143000374 hinge residues; other site 671143000375 Cytochrome c; Region: Cytochrom_C; cl11414 671143000376 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 671143000377 DNA-binding site [nucleotide binding]; DNA binding site 671143000378 RNA-binding motif; other site 671143000379 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 671143000380 catalytic core [active] 671143000381 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 671143000382 substrate binding site [chemical binding]; other site 671143000383 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 671143000384 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 671143000385 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 671143000386 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 671143000387 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 671143000388 NAD(P) binding site [chemical binding]; other site 671143000389 catalytic residues [active] 671143000390 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 671143000391 Amidinotransferase; Region: Amidinotransf; cl12043 671143000392 acetylornithine aminotransferase; Provisional; Region: PRK02627 671143000393 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 671143000394 inhibitor-cofactor binding pocket; inhibition site 671143000395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143000396 catalytic residue [active] 671143000397 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 671143000398 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 671143000399 PYR/PP interface [polypeptide binding]; other site 671143000400 dimer interface [polypeptide binding]; other site 671143000401 TPP binding site [chemical binding]; other site 671143000402 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 671143000403 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 671143000404 TPP-binding site [chemical binding]; other site 671143000405 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 671143000406 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 671143000407 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 671143000408 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 671143000409 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 671143000410 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 671143000411 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 671143000412 dimer interface [polypeptide binding]; other site 671143000413 decamer (pentamer of dimers) interface [polypeptide binding]; other site 671143000414 catalytic triad [active] 671143000415 peroxidatic and resolving cysteines [active] 671143000416 NIMA-related protein kinase; Provisional; Region: PTZ00266 671143000417 Domain of unknown function (DUF336); Region: DUF336; cl01249 671143000418 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 671143000419 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 671143000420 structural tetrad; other site 671143000421 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143000422 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 671143000423 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 671143000424 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 671143000425 putative active site [active] 671143000426 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 671143000427 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 671143000428 intersubunit interface [polypeptide binding]; other site 671143000429 active site 671143000430 zinc binding site [ion binding]; other site 671143000431 Na+ binding site [ion binding]; other site 671143000432 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 671143000433 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 671143000434 substrate binding site [chemical binding]; other site 671143000435 hexamer interface [polypeptide binding]; other site 671143000436 metal binding site [ion binding]; metal-binding site 671143000437 Peptidase family M48; Region: Peptidase_M48; pfam01435 671143000438 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 671143000439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143000440 binding surface 671143000441 TPR motif; other site 671143000442 Tetratricopeptide repeat; Region: TPR_16; pfam13432 671143000443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143000444 binding surface 671143000445 TPR motif; other site 671143000446 Tetratricopeptide repeat; Region: TPR_16; pfam13432 671143000447 Tetratricopeptide repeat; Region: TPR_16; pfam13432 671143000448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143000449 binding surface 671143000450 TPR motif; other site 671143000451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143000452 TPR motif; other site 671143000453 binding surface 671143000454 Tetratricopeptide repeat; Region: TPR_16; pfam13432 671143000455 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 671143000456 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 671143000457 DXD motif; other site 671143000458 PilZ domain; Region: PilZ; pfam07238 671143000459 PilZ domain; Region: PilZ; pfam07238 671143000460 acetyl-CoA synthetase; Provisional; Region: PRK00174 671143000461 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 671143000462 active site 671143000463 CoA binding site [chemical binding]; other site 671143000464 acyl-activating enzyme (AAE) consensus motif; other site 671143000465 AMP binding site [chemical binding]; other site 671143000466 acetate binding site [chemical binding]; other site 671143000467 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 671143000468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143000469 active site 671143000470 phosphorylation site [posttranslational modification] 671143000471 intermolecular recognition site; other site 671143000472 dimerization interface [polypeptide binding]; other site 671143000473 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 671143000474 DNA binding residues [nucleotide binding] 671143000475 dimerization interface [polypeptide binding]; other site 671143000476 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 671143000477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143000478 active site 671143000479 phosphorylation site [posttranslational modification] 671143000480 intermolecular recognition site; other site 671143000481 dimerization interface [polypeptide binding]; other site 671143000482 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 671143000483 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 671143000484 SLBB domain; Region: SLBB; pfam10531 671143000485 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 671143000486 Chain length determinant protein; Region: Wzz; cl15801 671143000487 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 671143000488 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 671143000489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143000490 TPR repeat; Region: TPR_11; pfam13414 671143000491 TPR motif; other site 671143000492 binding surface 671143000493 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 671143000494 Bacterial sugar transferase; Region: Bac_transf; pfam02397 671143000495 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 671143000496 O-Antigen ligase; Region: Wzy_C; pfam04932 671143000497 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 671143000498 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 671143000499 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 671143000500 putative active site [active] 671143000501 putative metal binding site [ion binding]; other site 671143000502 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 671143000503 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 671143000504 putative ADP-binding pocket [chemical binding]; other site 671143000505 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 671143000506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 671143000507 putative ADP-binding pocket [chemical binding]; other site 671143000508 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 671143000509 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 671143000510 putative ADP-binding pocket [chemical binding]; other site 671143000511 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929 671143000512 putative active site [active] 671143000513 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 671143000514 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 671143000515 putative ADP-binding pocket [chemical binding]; other site 671143000516 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 671143000517 CARDB; Region: CARDB; pfam07705 671143000518 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 671143000519 PIN domain; Region: PIN_3; cl17397 671143000520 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 671143000521 AAA domain; Region: AAA_14; pfam13173 671143000522 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 671143000523 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 671143000524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 671143000525 NAD(P) binding site [chemical binding]; other site 671143000526 active site 671143000527 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 671143000528 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 671143000529 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 671143000530 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 671143000531 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143000532 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 671143000533 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143000534 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143000535 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 671143000536 Asp-box motif; other site 671143000537 BNR repeat-like domain; Region: BNR_2; pfam13088 671143000538 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 671143000539 Domain of unknown function (DUF1736); Region: DUF1736; pfam08409 671143000540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143000541 TPR motif; other site 671143000542 TPR repeat; Region: TPR_11; pfam13414 671143000543 binding surface 671143000544 Tetratricopeptide repeat; Region: TPR_12; pfam13424 671143000545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143000546 TPR motif; other site 671143000547 binding surface 671143000548 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 671143000549 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 671143000550 Ligand binding site; other site 671143000551 Putative Catalytic site; other site 671143000552 DXD motif; other site 671143000553 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 671143000554 putative active site [active] 671143000555 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 671143000556 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 671143000557 HEPN domain; Region: HEPN; cl00824 671143000558 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 671143000559 active site 671143000560 NTP binding site [chemical binding]; other site 671143000561 metal binding triad [ion binding]; metal-binding site 671143000562 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 671143000563 Methyltransferase domain; Region: Methyltransf_23; pfam13489 671143000564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143000565 S-adenosylmethionine binding site [chemical binding]; other site 671143000566 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 671143000567 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 671143000568 Probable Catalytic site; other site 671143000569 metal-binding site 671143000570 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 671143000571 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 671143000572 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 671143000573 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 671143000574 Walker A/P-loop; other site 671143000575 ATP binding site [chemical binding]; other site 671143000576 Q-loop/lid; other site 671143000577 ABC transporter signature motif; other site 671143000578 Walker B; other site 671143000579 D-loop; other site 671143000580 H-loop/switch region; other site 671143000581 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 671143000582 putative carbohydrate binding site [chemical binding]; other site 671143000583 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 671143000584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 671143000585 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 671143000586 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 671143000587 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 671143000588 Rhamnan synthesis protein F; Region: RgpF; pfam05045 671143000589 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 671143000590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 671143000591 motif II; other site 671143000592 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 671143000593 active site 671143000594 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 671143000595 active site 671143000596 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 671143000597 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 671143000598 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 671143000599 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 671143000600 NADP binding site [chemical binding]; other site 671143000601 active site 671143000602 putative substrate binding site [chemical binding]; other site 671143000603 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 671143000604 oligomeric interface; other site 671143000605 putative active site [active] 671143000606 homodimer interface [polypeptide binding]; other site 671143000607 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 671143000608 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 671143000609 Probable Catalytic site; other site 671143000610 metal-binding site 671143000611 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 671143000612 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 671143000613 putative ADP-binding pocket [chemical binding]; other site 671143000614 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 671143000615 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 671143000616 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 671143000617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 671143000618 NAD(P) binding site [chemical binding]; other site 671143000619 active site 671143000620 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 671143000621 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 671143000622 putative ribose interaction site [chemical binding]; other site 671143000623 putative ADP binding site [chemical binding]; other site 671143000624 CTP synthetase; Validated; Region: pyrG; PRK05380 671143000625 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 671143000626 Catalytic site [active] 671143000627 active site 671143000628 UTP binding site [chemical binding]; other site 671143000629 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 671143000630 active site 671143000631 putative oxyanion hole; other site 671143000632 catalytic triad [active] 671143000633 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 671143000634 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 671143000635 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 671143000636 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 671143000637 Walker A/P-loop; other site 671143000638 ATP binding site [chemical binding]; other site 671143000639 Q-loop/lid; other site 671143000640 ABC transporter signature motif; other site 671143000641 Walker B; other site 671143000642 D-loop; other site 671143000643 H-loop/switch region; other site 671143000644 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 671143000645 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 671143000646 putative metal binding site; other site 671143000647 O-Antigen ligase; Region: Wzy_C; cl04850 671143000648 O-Antigen ligase; Region: Wzy_C; pfam04932 671143000649 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 671143000650 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 671143000651 putative active site [active] 671143000652 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 671143000653 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 671143000654 putative active site [active] 671143000655 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 671143000656 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 671143000657 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 671143000658 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 671143000659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 671143000660 active site 671143000661 motif I; other site 671143000662 motif II; other site 671143000663 S-adenosylmethionine synthetase; Validated; Region: PRK05250 671143000664 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 671143000665 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 671143000666 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 671143000667 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 671143000668 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 671143000669 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 671143000670 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 671143000671 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 671143000672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143000673 non-specific DNA binding site [nucleotide binding]; other site 671143000674 salt bridge; other site 671143000675 sequence-specific DNA binding site [nucleotide binding]; other site 671143000676 Adenosylhomocysteinase; Provisional; Region: PTZ00075 671143000677 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 671143000678 homotetramer interface [polypeptide binding]; other site 671143000679 ligand binding site [chemical binding]; other site 671143000680 catalytic site [active] 671143000681 NAD binding site [chemical binding]; other site 671143000682 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 671143000683 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 671143000684 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 671143000685 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 671143000686 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 671143000687 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 671143000688 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143000689 Radical SAM superfamily; Region: Radical_SAM; pfam04055 671143000690 FeS/SAM binding site; other site 671143000691 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 671143000692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143000693 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 671143000694 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 671143000695 Probable Catalytic site; other site 671143000696 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 671143000697 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 671143000698 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 671143000699 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 671143000700 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 671143000701 Domain of unknown function (DUF1736); Region: DUF1736; pfam08409 671143000702 TPR repeat; Region: TPR_11; pfam13414 671143000703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143000704 binding surface 671143000705 TPR motif; other site 671143000706 TPR repeat; Region: TPR_11; pfam13414 671143000707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143000708 binding surface 671143000709 TPR motif; other site 671143000710 TPR repeat; Region: TPR_11; pfam13414 671143000711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143000712 TPR motif; other site 671143000713 TPR repeat; Region: TPR_11; pfam13414 671143000714 binding surface 671143000715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143000716 binding surface 671143000717 TPR motif; other site 671143000718 TPR repeat; Region: TPR_11; pfam13414 671143000719 Tetratricopeptide repeat; Region: TPR_16; pfam13432 671143000720 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 671143000721 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 671143000722 Ligand binding site; other site 671143000723 Putative Catalytic site; other site 671143000724 DXD motif; other site 671143000725 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 671143000726 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 671143000727 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 671143000728 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 671143000729 B12 binding site [chemical binding]; other site 671143000730 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143000731 FeS/SAM binding site; other site 671143000732 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 671143000733 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 671143000734 active site 671143000735 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 671143000736 Ligand binding site; other site 671143000737 Ligand binding site; other site 671143000738 Ligand binding site; other site 671143000739 Putative Catalytic site; other site 671143000740 DXD motif; other site 671143000741 Predicted permeases [General function prediction only]; Region: COG0795 671143000742 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 671143000743 Predicted permeases [General function prediction only]; Region: COG0795 671143000744 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 671143000745 CAAX protease self-immunity; Region: Abi; pfam02517 671143000746 BNR repeat-like domain; Region: BNR_2; pfam13088 671143000747 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 671143000748 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 671143000749 Competence protein; Region: Competence; pfam03772 671143000750 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 671143000751 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 671143000752 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 671143000753 generic binding surface II; other site 671143000754 generic binding surface I; other site 671143000755 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 671143000756 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 671143000757 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 671143000758 substrate binding pocket [chemical binding]; other site 671143000759 chain length determination region; other site 671143000760 substrate-Mg2+ binding site; other site 671143000761 catalytic residues [active] 671143000762 aspartate-rich region 1; other site 671143000763 active site lid residues [active] 671143000764 aspartate-rich region 2; other site 671143000765 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 671143000766 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 671143000767 RNA binding surface [nucleotide binding]; other site 671143000768 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 671143000769 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 671143000770 ATP-NAD kinase; Region: NAD_kinase; pfam01513 671143000771 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 671143000772 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 671143000773 Walker A/P-loop; other site 671143000774 ATP binding site [chemical binding]; other site 671143000775 Q-loop/lid; other site 671143000776 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 671143000777 ABC transporter signature motif; other site 671143000778 Walker B; other site 671143000779 D-loop; other site 671143000780 H-loop/switch region; other site 671143000781 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 671143000782 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 671143000783 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 671143000784 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 671143000785 GTP1/OBG; Region: GTP1_OBG; pfam01018 671143000786 Obg GTPase; Region: Obg; cd01898 671143000787 G1 box; other site 671143000788 GTP/Mg2+ binding site [chemical binding]; other site 671143000789 Switch I region; other site 671143000790 G2 box; other site 671143000791 G3 box; other site 671143000792 Switch II region; other site 671143000793 G4 box; other site 671143000794 G5 box; other site 671143000795 gamma-glutamyl kinase; Provisional; Region: PRK05429 671143000796 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 671143000797 nucleotide binding site [chemical binding]; other site 671143000798 homotetrameric interface [polypeptide binding]; other site 671143000799 putative phosphate binding site [ion binding]; other site 671143000800 putative allosteric binding site; other site 671143000801 PUA domain; Region: PUA; pfam01472 671143000802 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 671143000803 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 671143000804 putative catalytic cysteine [active] 671143000805 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 671143000806 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 671143000807 active site 671143000808 (T/H)XGH motif; other site 671143000809 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 671143000810 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 671143000811 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 671143000812 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 671143000813 active site 671143000814 APC basic domain; Region: APC_basic; pfam05956 671143000815 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 671143000816 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 671143000817 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 671143000818 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 671143000819 substrate binding site [chemical binding]; other site 671143000820 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 671143000821 Phosphoglycerate kinase; Region: PGK; pfam00162 671143000822 hinge regions; other site 671143000823 ADP binding site [chemical binding]; other site 671143000824 catalytic site [active] 671143000825 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 671143000826 triosephosphate isomerase; Provisional; Region: PRK14567 671143000827 substrate binding site [chemical binding]; other site 671143000828 dimer interface [polypeptide binding]; other site 671143000829 catalytic triad [active] 671143000830 Preprotein translocase SecG subunit; Region: SecG; pfam03840 671143000831 MutL protein; Region: MutL; pfam13941 671143000832 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 671143000833 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 671143000834 toxin interface [polypeptide binding]; other site 671143000835 Zn binding site [ion binding]; other site 671143000836 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 671143000837 SIR2-like domain; Region: SIR2_2; pfam13289 671143000838 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 671143000839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143000840 Walker A motif; other site 671143000841 ATP binding site [chemical binding]; other site 671143000842 Walker B motif; other site 671143000843 arginine finger; other site 671143000844 OsmC-like protein; Region: OsmC; pfam02566 671143000845 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 671143000846 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 671143000847 toxin-antitoxin system, toxin component, Txe/YoeB family; Region: toxin_Txe_YoeB; TIGR02116 671143000848 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 671143000849 putative transposase OrfB; Reviewed; Region: PHA02517 671143000850 HTH-like domain; Region: HTH_21; pfam13276 671143000851 Integrase core domain; Region: rve; pfam00665 671143000852 Integrase core domain; Region: rve_3; pfam13683 671143000853 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 671143000854 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 671143000855 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 671143000856 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143000857 non-specific DNA binding site [nucleotide binding]; other site 671143000858 salt bridge; other site 671143000859 sequence-specific DNA binding site [nucleotide binding]; other site 671143000860 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 671143000861 Uncharacterized conserved protein [Function unknown]; Region: COG1801 671143000862 aconitate hydratase; Validated; Region: PRK07229 671143000863 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 671143000864 substrate binding site [chemical binding]; other site 671143000865 ligand binding site [chemical binding]; other site 671143000866 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 671143000867 substrate binding site [chemical binding]; other site 671143000868 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 671143000869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143000870 non-specific DNA binding site [nucleotide binding]; other site 671143000871 salt bridge; other site 671143000872 sequence-specific DNA binding site [nucleotide binding]; other site 671143000873 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 671143000874 active site 671143000875 DNA polymerase IV; Validated; Region: PRK02406 671143000876 DNA binding site [nucleotide binding] 671143000877 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 671143000878 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 671143000879 active site 671143000880 NTP binding site [chemical binding]; other site 671143000881 metal binding triad [ion binding]; metal-binding site 671143000882 antibiotic binding site [chemical binding]; other site 671143000883 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 671143000884 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 671143000885 AAA domain; Region: AAA_30; pfam13604 671143000886 Family description; Region: UvrD_C_2; pfam13538 671143000887 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 671143000888 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 671143000889 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 671143000890 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 671143000891 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 671143000892 ATP binding site [chemical binding]; other site 671143000893 putative Mg++ binding site [ion binding]; other site 671143000894 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 671143000895 nucleotide binding region [chemical binding]; other site 671143000896 ATP-binding site [chemical binding]; other site 671143000897 RQC domain; Region: RQC; pfam09382 671143000898 HRDC domain; Region: HRDC; pfam00570 671143000899 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 671143000900 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 671143000901 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 671143000902 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 671143000903 putative transposase OrfB; Reviewed; Region: PHA02517 671143000904 Integrase core domain; Region: rve; pfam00665 671143000905 Integrase core domain; Region: rve_3; pfam13683 671143000906 HEPN domain; Region: HEPN; cl00824 671143000907 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 671143000908 Cu(I) binding site [ion binding]; other site 671143000909 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 671143000910 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 671143000911 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 671143000912 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15379567; Product type t : transporter 671143000913 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15379567; Product type t : transporter 671143000914 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 671143000915 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 671143000916 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 671143000917 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 671143000918 Ligand Binding Site [chemical binding]; other site 671143000919 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 671143000920 GAF domain; Region: GAF_3; pfam13492 671143000921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143000922 dimer interface [polypeptide binding]; other site 671143000923 phosphorylation site [posttranslational modification] 671143000924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143000925 ATP binding site [chemical binding]; other site 671143000926 Mg2+ binding site [ion binding]; other site 671143000927 G-X-G motif; other site 671143000928 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 671143000929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143000930 active site 671143000931 phosphorylation site [posttranslational modification] 671143000932 intermolecular recognition site; other site 671143000933 dimerization interface [polypeptide binding]; other site 671143000934 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 671143000935 DNA binding site [nucleotide binding] 671143000936 PAS domain S-box; Region: sensory_box; TIGR00229 671143000937 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143000938 putative active site [active] 671143000939 heme pocket [chemical binding]; other site 671143000940 PAS domain S-box; Region: sensory_box; TIGR00229 671143000941 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143000942 putative active site [active] 671143000943 heme pocket [chemical binding]; other site 671143000944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143000945 histidine kinase; Provisional; Region: PRK13557 671143000946 putative active site [active] 671143000947 heme pocket [chemical binding]; other site 671143000948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143000949 dimer interface [polypeptide binding]; other site 671143000950 phosphorylation site [posttranslational modification] 671143000951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143000952 ATP binding site [chemical binding]; other site 671143000953 Mg2+ binding site [ion binding]; other site 671143000954 G-X-G motif; other site 671143000955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143000956 active site 671143000957 phosphorylation site [posttranslational modification] 671143000958 intermolecular recognition site; other site 671143000959 dimerization interface [polypeptide binding]; other site 671143000960 M28 Zn-Peptidases; Region: M28_like_1; cd05640 671143000961 Peptidase family M28; Region: Peptidase_M28; pfam04389 671143000962 metal binding site [ion binding]; metal-binding site 671143000963 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 671143000964 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 671143000965 ATP binding site [chemical binding]; other site 671143000966 Mg++ binding site [ion binding]; other site 671143000967 motif III; other site 671143000968 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 671143000969 nucleotide binding region [chemical binding]; other site 671143000970 ATP-binding site [chemical binding]; other site 671143000971 ORF6N domain; Region: ORF6N; pfam10543 671143000972 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143000973 non-specific DNA binding site [nucleotide binding]; other site 671143000974 salt bridge; other site 671143000975 sequence-specific DNA binding site [nucleotide binding]; other site 671143000976 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 671143000977 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 671143000978 metal binding site [ion binding]; metal-binding site 671143000979 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 671143000980 YciI-like protein; Reviewed; Region: PRK12866 671143000981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 671143000982 Protein of unknown function (DUF433); Region: DUF433; cl01030 671143000983 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 671143000984 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 671143000985 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 671143000986 active site 671143000987 methionine sulfoxide reductase A; Provisional; Region: PRK14054 671143000988 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 671143000989 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 671143000990 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 671143000991 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 671143000992 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 671143000993 dimer interface [polypeptide binding]; other site 671143000994 active site residues [active] 671143000995 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 671143000996 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 671143000997 homodimer interface [polypeptide binding]; other site 671143000998 metal binding site [ion binding]; metal-binding site 671143000999 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 671143001000 homodimer interface [polypeptide binding]; other site 671143001001 active site 671143001002 putative chemical substrate binding site [chemical binding]; other site 671143001003 metal binding site [ion binding]; metal-binding site 671143001004 ZIP Zinc transporter; Region: Zip; pfam02535 671143001005 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 671143001006 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 671143001007 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 671143001008 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 671143001009 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 671143001010 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 671143001011 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 671143001012 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 671143001013 CARDB; Region: CARDB; pfam07705 671143001014 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 671143001015 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 671143001016 N-acetyl-D-glucosamine binding site [chemical binding]; other site 671143001017 catalytic residue [active] 671143001018 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 671143001019 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 671143001020 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 671143001021 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 671143001022 NAD(P) binding pocket [chemical binding]; other site 671143001023 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 671143001024 molybdopterin cofactor binding site; other site 671143001025 The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761 671143001026 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 671143001027 putative [4Fe-4S] binding site [ion binding]; other site 671143001028 putative molybdopterin cofactor binding site [chemical binding]; other site 671143001029 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 671143001030 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 671143001031 active site 671143001032 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 671143001033 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 671143001034 FTR, proximal lobe; Region: FTR_C; pfam02741 671143001035 FwdC/FmdC. This domain of unknown function is found in the subunit C of formylmethanofuran dehydrogenase, an enzyme that catalyzes the first step in methane formation from CO2 in methanogenic archaea, hyperthermophiles and bacteria. There are two...; Region: FwdC/FmdC; cd00980 671143001036 putative subunit interface; other site 671143001037 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 671143001038 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 671143001039 trimer interface I [polypeptide binding]; other site 671143001040 putative substrate binding pocket [chemical binding]; other site 671143001041 trimer interface II [polypeptide binding]; other site 671143001042 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 671143001043 ATP-grasp domain; Region: ATP-grasp_4; cl17255 671143001044 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 671143001045 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 671143001046 CoA binding domain; Region: CoA_binding_2; pfam13380 671143001047 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 671143001048 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 671143001049 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 671143001050 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 671143001051 Esterase/lipase [General function prediction only]; Region: COG1647 671143001052 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 671143001053 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 671143001054 inhibitor-cofactor binding pocket; inhibition site 671143001055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143001056 catalytic residue [active] 671143001057 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 671143001058 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 671143001059 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 671143001060 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 671143001061 Protein of unknown function (DUF447); Region: DUF447; pfam04289 671143001062 dihydropteroate synthase-related protein; Region: TIGR00284 671143001063 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 671143001064 substrate binding pocket [chemical binding]; other site 671143001065 inhibitor binding site; inhibition site 671143001066 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 671143001067 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 671143001068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 671143001069 NAD(P) binding site [chemical binding]; other site 671143001070 active site 671143001071 biotin synthase; Region: bioB; TIGR00433 671143001072 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143001073 FeS/SAM binding site; other site 671143001074 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 671143001075 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 671143001076 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 671143001077 inhibitor-cofactor binding pocket; inhibition site 671143001078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143001079 catalytic residue [active] 671143001080 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 671143001081 AAA domain; Region: AAA_26; pfam13500 671143001082 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 671143001083 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 671143001084 Sporulation related domain; Region: SPOR; pfam05036 671143001085 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143001086 dimerization interface [polypeptide binding]; other site 671143001087 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 671143001088 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 671143001089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143001090 putative active site [active] 671143001091 heme pocket [chemical binding]; other site 671143001092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143001093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143001094 dimer interface [polypeptide binding]; other site 671143001095 phosphorylation site [posttranslational modification] 671143001096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143001097 ATP binding site [chemical binding]; other site 671143001098 Mg2+ binding site [ion binding]; other site 671143001099 G-X-G motif; other site 671143001100 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 671143001101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143001102 active site 671143001103 phosphorylation site [posttranslational modification] 671143001104 intermolecular recognition site; other site 671143001105 dimerization interface [polypeptide binding]; other site 671143001106 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 671143001107 Zn2+ binding site [ion binding]; other site 671143001108 Mg2+ binding site [ion binding]; other site 671143001109 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143001110 dimerization interface [polypeptide binding]; other site 671143001111 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 671143001112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143001113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143001114 phosphorylation site [posttranslational modification] 671143001115 dimer interface [polypeptide binding]; other site 671143001116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143001117 ATP binding site [chemical binding]; other site 671143001118 Mg2+ binding site [ion binding]; other site 671143001119 G-X-G motif; other site 671143001120 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 671143001121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143001122 active site 671143001123 phosphorylation site [posttranslational modification] 671143001124 intermolecular recognition site; other site 671143001125 dimerization interface [polypeptide binding]; other site 671143001126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 671143001127 dimer interface [polypeptide binding]; other site 671143001128 phosphorylation site [posttranslational modification] 671143001129 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 671143001130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 671143001131 motif II; other site 671143001132 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 671143001133 glucokinase, proteobacterial type; Region: glk; TIGR00749 671143001134 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 671143001135 nucleotide binding site [chemical binding]; other site 671143001136 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 671143001137 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 671143001138 putative active site [active] 671143001139 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 671143001140 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 671143001141 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 671143001142 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 671143001143 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 671143001144 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 671143001145 SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798 671143001146 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 671143001147 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 671143001148 TolR protein; Region: tolR; TIGR02801 671143001149 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 671143001150 TolB amino-terminal domain; Region: TolB_N; pfam04052 671143001151 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 671143001152 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 671143001153 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 671143001154 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 671143001155 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 671143001156 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 671143001157 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 671143001158 ligand binding site [chemical binding]; other site 671143001159 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 671143001160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143001161 binding surface 671143001162 TPR motif; other site 671143001163 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 671143001164 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 671143001165 tartrate dehydrogenase; Region: TTC; TIGR02089 671143001166 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 671143001167 G1 box; other site 671143001168 GTP/Mg2+ binding site [chemical binding]; other site 671143001169 Switch I region; other site 671143001170 G2 box; other site 671143001171 G3 box; other site 671143001172 Switch II region; other site 671143001173 G4 box; other site 671143001174 G5 box; other site 671143001175 TPR repeat; Region: TPR_11; pfam13414 671143001176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143001177 TPR motif; other site 671143001178 binding surface 671143001179 TPR repeat; Region: TPR_11; pfam13414 671143001180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143001181 binding surface 671143001182 TPR repeat; Region: TPR_11; pfam13414 671143001183 TPR motif; other site 671143001184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143001185 binding surface 671143001186 Tetratricopeptide repeat; Region: TPR_16; pfam13432 671143001187 TPR motif; other site 671143001188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143001189 binding surface 671143001190 TPR motif; other site 671143001191 TPR repeat; Region: TPR_11; pfam13414 671143001192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143001193 binding surface 671143001194 TPR motif; other site 671143001195 TPR repeat; Region: TPR_11; pfam13414 671143001196 TPR repeat; Region: TPR_11; pfam13414 671143001197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143001198 binding surface 671143001199 TPR motif; other site 671143001200 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 671143001201 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 671143001202 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 671143001203 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 671143001204 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 671143001205 active site 671143001206 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 671143001207 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 671143001208 5S rRNA interface [nucleotide binding]; other site 671143001209 CTC domain interface [polypeptide binding]; other site 671143001210 L16 interface [polypeptide binding]; other site 671143001211 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 671143001212 putative active site [active] 671143001213 catalytic residue [active] 671143001214 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 671143001215 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 671143001216 dimer interface [polypeptide binding]; other site 671143001217 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 671143001218 ssDNA binding site [nucleotide binding]; other site 671143001219 tetramer (dimer of dimers) interface [polypeptide binding]; other site 671143001220 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 671143001221 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 671143001222 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 671143001223 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 671143001224 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 671143001225 replicative DNA helicase; Region: DnaB; TIGR00665 671143001226 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 671143001227 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 671143001228 Walker A motif; other site 671143001229 ATP binding site [chemical binding]; other site 671143001230 Walker B motif; other site 671143001231 DNA binding loops [nucleotide binding] 671143001232 DNA repair protein RadA; Provisional; Region: PRK11823 671143001233 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 671143001234 Walker A motif/ATP binding site; other site 671143001235 ATP binding site [chemical binding]; other site 671143001236 Walker B motif; other site 671143001237 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 671143001238 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 671143001239 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 671143001240 putative active site [active] 671143001241 TRAM domain; Region: TRAM; cl01282 671143001242 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 671143001243 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 671143001244 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 671143001245 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 671143001246 active site 671143001247 HIGH motif; other site 671143001248 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 671143001249 KMSKS motif; other site 671143001250 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 671143001251 tRNA binding surface [nucleotide binding]; other site 671143001252 anticodon binding site; other site 671143001253 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 671143001254 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 671143001255 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 671143001256 elongation factor Tu; Reviewed; Region: PRK00049 671143001257 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 671143001258 G1 box; other site 671143001259 GEF interaction site [polypeptide binding]; other site 671143001260 GTP/Mg2+ binding site [chemical binding]; other site 671143001261 Switch I region; other site 671143001262 G2 box; other site 671143001263 G3 box; other site 671143001264 Switch II region; other site 671143001265 G4 box; other site 671143001266 G5 box; other site 671143001267 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 671143001268 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 671143001269 Antibiotic Binding Site [chemical binding]; other site 671143001270 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 671143001271 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 671143001272 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 671143001273 putative homodimer interface [polypeptide binding]; other site 671143001274 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 671143001275 heterodimer interface [polypeptide binding]; other site 671143001276 homodimer interface [polypeptide binding]; other site 671143001277 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 671143001278 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 671143001279 23S rRNA interface [nucleotide binding]; other site 671143001280 L7/L12 interface [polypeptide binding]; other site 671143001281 putative thiostrepton binding site; other site 671143001282 L25 interface [polypeptide binding]; other site 671143001283 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 671143001284 mRNA/rRNA interface [nucleotide binding]; other site 671143001285 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 671143001286 23S rRNA interface [nucleotide binding]; other site 671143001287 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 671143001288 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 671143001289 peripheral dimer interface [polypeptide binding]; other site 671143001290 core dimer interface [polypeptide binding]; other site 671143001291 L10 interface [polypeptide binding]; other site 671143001292 L11 interface [polypeptide binding]; other site 671143001293 putative EF-Tu interaction site [polypeptide binding]; other site 671143001294 putative EF-G interaction site [polypeptide binding]; other site 671143001295 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 671143001296 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 671143001297 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 671143001298 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 671143001299 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 671143001300 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 671143001301 RPB3 interaction site [polypeptide binding]; other site 671143001302 RPB1 interaction site [polypeptide binding]; other site 671143001303 RPB11 interaction site [polypeptide binding]; other site 671143001304 RPB10 interaction site [polypeptide binding]; other site 671143001305 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 671143001306 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 671143001307 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 671143001308 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 671143001309 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 671143001310 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 671143001311 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 671143001312 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 671143001313 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 671143001314 DNA binding site [nucleotide binding] 671143001315 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 671143001316 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 671143001317 S17 interaction site [polypeptide binding]; other site 671143001318 S8 interaction site; other site 671143001319 16S rRNA interaction site [nucleotide binding]; other site 671143001320 streptomycin interaction site [chemical binding]; other site 671143001321 23S rRNA interaction site [nucleotide binding]; other site 671143001322 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 671143001323 30S ribosomal protein S7; Validated; Region: PRK05302 671143001324 elongation factor G; Reviewed; Region: PRK00007 671143001325 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 671143001326 G1 box; other site 671143001327 putative GEF interaction site [polypeptide binding]; other site 671143001328 GTP/Mg2+ binding site [chemical binding]; other site 671143001329 Switch I region; other site 671143001330 G2 box; other site 671143001331 G3 box; other site 671143001332 Switch II region; other site 671143001333 G4 box; other site 671143001334 G5 box; other site 671143001335 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 671143001336 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 671143001337 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 671143001338 elongation factor Tu; Reviewed; Region: PRK00049 671143001339 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 671143001340 G1 box; other site 671143001341 GEF interaction site [polypeptide binding]; other site 671143001342 GTP/Mg2+ binding site [chemical binding]; other site 671143001343 Switch I region; other site 671143001344 G2 box; other site 671143001345 G3 box; other site 671143001346 Switch II region; other site 671143001347 G4 box; other site 671143001348 G5 box; other site 671143001349 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 671143001350 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 671143001351 Antibiotic Binding Site [chemical binding]; other site 671143001352 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 671143001353 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 671143001354 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 671143001355 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 671143001356 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 671143001357 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 671143001358 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 671143001359 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 671143001360 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 671143001361 putative translocon binding site; other site 671143001362 protein-rRNA interface [nucleotide binding]; other site 671143001363 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 671143001364 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 671143001365 G-X-X-G motif; other site 671143001366 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 671143001367 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 671143001368 23S rRNA interface [nucleotide binding]; other site 671143001369 5S rRNA interface [nucleotide binding]; other site 671143001370 putative antibiotic binding site [chemical binding]; other site 671143001371 L25 interface [polypeptide binding]; other site 671143001372 L27 interface [polypeptide binding]; other site 671143001373 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 671143001374 23S rRNA interface [nucleotide binding]; other site 671143001375 putative translocon interaction site; other site 671143001376 signal recognition particle (SRP54) interaction site; other site 671143001377 L23 interface [polypeptide binding]; other site 671143001378 trigger factor interaction site; other site 671143001379 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 671143001380 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 671143001381 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 671143001382 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 671143001383 RNA binding site [nucleotide binding]; other site 671143001384 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 671143001385 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 671143001386 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 671143001387 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 671143001388 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 671143001389 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 671143001390 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 671143001391 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 671143001392 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 671143001393 5S rRNA interface [nucleotide binding]; other site 671143001394 23S rRNA interface [nucleotide binding]; other site 671143001395 L5 interface [polypeptide binding]; other site 671143001396 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 671143001397 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 671143001398 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 671143001399 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 671143001400 23S rRNA binding site [nucleotide binding]; other site 671143001401 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 671143001402 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 671143001403 SecY translocase; Region: SecY; pfam00344 671143001404 adenylate kinase; Reviewed; Region: adk; PRK00279 671143001405 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 671143001406 AMP-binding site [chemical binding]; other site 671143001407 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 671143001408 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 671143001409 active site 671143001410 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 671143001411 rRNA binding site [nucleotide binding]; other site 671143001412 predicted 30S ribosome binding site; other site 671143001413 Protein kinase domain; Region: Pkinase; pfam00069 671143001414 30S ribosomal protein S11; Validated; Region: PRK05309 671143001415 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 671143001416 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 671143001417 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 671143001418 RNA binding surface [nucleotide binding]; other site 671143001419 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 671143001420 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 671143001421 alphaNTD homodimer interface [polypeptide binding]; other site 671143001422 alphaNTD - beta interaction site [polypeptide binding]; other site 671143001423 alphaNTD - beta' interaction site [polypeptide binding]; other site 671143001424 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 671143001425 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 671143001426 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 671143001427 elongation factor G; Reviewed; Region: PRK12740 671143001428 G1 box; other site 671143001429 putative GEF interaction site [polypeptide binding]; other site 671143001430 GTP/Mg2+ binding site [chemical binding]; other site 671143001431 Switch I region; other site 671143001432 G2 box; other site 671143001433 G3 box; other site 671143001434 Switch II region; other site 671143001435 G4 box; other site 671143001436 G5 box; other site 671143001437 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 671143001438 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 671143001439 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 671143001440 ribosome maturation protein RimP; Reviewed; Region: PRK00092 671143001441 Sm and related proteins; Region: Sm_like; cl00259 671143001442 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 671143001443 putative oligomer interface [polypeptide binding]; other site 671143001444 putative RNA binding site [nucleotide binding]; other site 671143001445 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 671143001446 NusA N-terminal domain; Region: NusA_N; pfam08529 671143001447 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 671143001448 RNA binding site [nucleotide binding]; other site 671143001449 homodimer interface [polypeptide binding]; other site 671143001450 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 671143001451 G-X-X-G motif; other site 671143001452 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 671143001453 G-X-X-G motif; other site 671143001454 Protein of unknown function (DUF448); Region: DUF448; pfam04296 671143001455 putative RNA binding cleft [nucleotide binding]; other site 671143001456 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 671143001457 translation initiation factor IF-2; Validated; Region: infB; PRK05306 671143001458 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 671143001459 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 671143001460 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 671143001461 G1 box; other site 671143001462 putative GEF interaction site [polypeptide binding]; other site 671143001463 GTP/Mg2+ binding site [chemical binding]; other site 671143001464 Switch I region; other site 671143001465 G2 box; other site 671143001466 G3 box; other site 671143001467 Switch II region; other site 671143001468 G4 box; other site 671143001469 G5 box; other site 671143001470 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 671143001471 Translation-initiation factor 2; Region: IF-2; pfam11987 671143001472 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 671143001473 Protein of unknown function (DUF503); Region: DUF503; pfam04456 671143001474 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 671143001475 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 671143001476 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 671143001477 active site 671143001478 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 671143001479 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 671143001480 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 671143001481 RNA binding site [nucleotide binding]; other site 671143001482 active site 671143001483 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 671143001484 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 671143001485 active site 671143001486 Riboflavin kinase; Region: Flavokinase; pfam01687 671143001487 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 671143001488 16S/18S rRNA binding site [nucleotide binding]; other site 671143001489 S13e-L30e interaction site [polypeptide binding]; other site 671143001490 25S rRNA binding site [nucleotide binding]; other site 671143001491 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 671143001492 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 671143001493 RNase E interface [polypeptide binding]; other site 671143001494 trimer interface [polypeptide binding]; other site 671143001495 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 671143001496 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 671143001497 RNase E interface [polypeptide binding]; other site 671143001498 trimer interface [polypeptide binding]; other site 671143001499 active site 671143001500 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 671143001501 putative nucleic acid binding region [nucleotide binding]; other site 671143001502 G-X-X-G motif; other site 671143001503 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 671143001504 RNA binding site [nucleotide binding]; other site 671143001505 domain interface; other site 671143001506 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 671143001507 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 671143001508 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 671143001509 adenylosuccinate lyase; Provisional; Region: PRK07492 671143001510 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 671143001511 tetramer interface [polypeptide binding]; other site 671143001512 active site 671143001513 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 671143001514 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 671143001515 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 671143001516 putative active site [active] 671143001517 catalytic triad [active] 671143001518 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 671143001519 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 671143001520 dimerization interface [polypeptide binding]; other site 671143001521 ATP binding site [chemical binding]; other site 671143001522 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 671143001523 dimerization interface [polypeptide binding]; other site 671143001524 ATP binding site [chemical binding]; other site 671143001525 homoserine dehydrogenase; Provisional; Region: PRK06349 671143001526 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 671143001527 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 671143001528 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 671143001529 threonine synthase; Reviewed; Region: PRK06721 671143001530 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 671143001531 homodimer interface [polypeptide binding]; other site 671143001532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143001533 catalytic residue [active] 671143001534 Haem-binding domain; Region: Haem_bd; pfam14376 671143001535 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 671143001536 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 671143001537 FAD binding site [chemical binding]; other site 671143001538 homotetramer interface [polypeptide binding]; other site 671143001539 substrate binding pocket [chemical binding]; other site 671143001540 catalytic base [active] 671143001541 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 671143001542 Walker A; other site 671143001543 Protein of unknown function DUF91; Region: DUF91; cl00709 671143001544 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 671143001545 YcfA-like protein; Region: YcfA; pfam07927 671143001546 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 671143001547 Coenzyme A transferase; Region: CoA_trans; cl17247 671143001548 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 671143001549 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 671143001550 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 671143001551 putative active site [active] 671143001552 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 671143001553 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 671143001554 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 671143001555 TMAO/DMSO reductase; Reviewed; Region: PRK05363 671143001556 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 671143001557 Moco binding site; other site 671143001558 metal coordination site [ion binding]; other site 671143001559 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 671143001560 dimer interface [polypeptide binding]; other site 671143001561 ADP-ribose binding site [chemical binding]; other site 671143001562 active site 671143001563 nudix motif; other site 671143001564 metal binding site [ion binding]; metal-binding site 671143001565 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143001566 Radical SAM superfamily; Region: Radical_SAM; pfam04055 671143001567 FeS/SAM binding site; other site 671143001568 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 671143001569 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 671143001570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143001571 FeS/SAM binding site; other site 671143001572 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 671143001573 Ligand binding site; other site 671143001574 Putative Catalytic site; other site 671143001575 DXD motif; other site 671143001576 N2227-like protein; Region: N2227; pfam07942 671143001577 Methyltransferase domain; Region: Methyltransf_31; pfam13847 671143001578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143001579 S-adenosylmethionine binding site [chemical binding]; other site 671143001580 Predicted transcriptional regulator [Transcription]; Region: COG3905 671143001581 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 671143001582 formate dehydrogenase; Provisional; Region: PLN03139 671143001583 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 671143001584 methionine sulfoxide reductase B; Provisional; Region: PRK00222 671143001585 SelR domain; Region: SelR; pfam01641 671143001586 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 671143001587 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 671143001588 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 671143001589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143001590 sequence-specific DNA binding site [nucleotide binding]; other site 671143001591 salt bridge; other site 671143001592 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 671143001593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143001594 non-specific DNA binding site [nucleotide binding]; other site 671143001595 salt bridge; other site 671143001596 sequence-specific DNA binding site [nucleotide binding]; other site 671143001597 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 671143001598 Transglycosylase; Region: Transgly; pfam00912 671143001599 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 671143001600 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 671143001601 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 671143001602 Protein of unknown function (DUF497); Region: DUF497; pfam04365 671143001603 Protein of unknown function (DUF3680); Region: DUF3680; pfam12441 671143001604 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 671143001605 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 671143001606 FAD binding site [chemical binding]; other site 671143001607 homotetramer interface [polypeptide binding]; other site 671143001608 substrate binding pocket [chemical binding]; other site 671143001609 catalytic base [active] 671143001610 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 671143001611 Ligand binding site [chemical binding]; other site 671143001612 Electron transfer flavoprotein domain; Region: ETF; pfam01012 671143001613 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 671143001614 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 671143001615 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 671143001616 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 671143001617 4Fe-4S binding domain; Region: Fer4; cl02805 671143001618 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 671143001619 Cysteine-rich domain; Region: CCG; pfam02754 671143001620 Cysteine-rich domain; Region: CCG; pfam02754 671143001621 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2569860, 8099072, 8805541; Product type e : enzyme 671143001622 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2569860, 8099072, 8805541; Product type e : enzyme 671143001623 acetyl-CoA acetyltransferase; Provisional; Region: PRK06365 671143001624 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 671143001625 active site 671143001626 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 671143001627 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 671143001628 DUF35 OB-fold domain; Region: DUF35; pfam01796 671143001629 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 671143001630 homodimer interface [polypeptide binding]; other site 671143001631 chemical substrate binding site [chemical binding]; other site 671143001632 oligomer interface [polypeptide binding]; other site 671143001633 metal binding site [ion binding]; metal-binding site 671143001634 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 671143001635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143001636 Walker A motif; other site 671143001637 ATP binding site [chemical binding]; other site 671143001638 Walker B motif; other site 671143001639 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 671143001640 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 671143001641 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 671143001642 active site 671143001643 HIGH motif; other site 671143001644 nucleotide binding site [chemical binding]; other site 671143001645 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 671143001646 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 671143001647 active site 671143001648 KMSKS motif; other site 671143001649 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 671143001650 tRNA binding surface [nucleotide binding]; other site 671143001651 anticodon binding site; other site 671143001652 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 671143001653 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 671143001654 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 671143001655 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 671143001656 nucleotide binding site [chemical binding]; other site 671143001657 Type III pantothenate kinase; Region: Pan_kinase; cl17198 671143001658 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 671143001659 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 671143001660 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 671143001661 23S rRNA interface [nucleotide binding]; other site 671143001662 L3 interface [polypeptide binding]; other site 671143001663 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 671143001664 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 671143001665 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 671143001666 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 671143001667 heterotetramer interface [polypeptide binding]; other site 671143001668 active site pocket [active] 671143001669 cleavage site 671143001670 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 671143001671 rRNA interaction site [nucleotide binding]; other site 671143001672 S8 interaction site; other site 671143001673 putative laminin-1 binding site; other site 671143001674 elongation factor Ts; Reviewed; Region: tsf; PRK12332 671143001675 UBA/TS-N domain; Region: UBA; pfam00627 671143001676 Elongation factor TS; Region: EF_TS; pfam00889 671143001677 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 671143001678 putative nucleotide binding site [chemical binding]; other site 671143001679 uridine monophosphate binding site [chemical binding]; other site 671143001680 homohexameric interface [polypeptide binding]; other site 671143001681 ribosome recycling factor; Reviewed; Region: frr; PRK00083 671143001682 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 671143001683 hinge region; other site 671143001684 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 671143001685 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 671143001686 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 671143001687 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 671143001688 putative active site [active] 671143001689 catalytic triad [active] 671143001690 putative dimer interface [polypeptide binding]; other site 671143001691 This domain is found in peptide chain release factors; Region: PCRF; smart00937 671143001692 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 671143001693 RF-1 domain; Region: RF-1; pfam00472 671143001694 hypothetical protein; Provisional; Region: PRK09272 671143001695 Protein of unknown function, DUF486; Region: DUF486; cl01236 671143001696 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 671143001697 Peptidase family M23; Region: Peptidase_M23; pfam01551 671143001698 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 671143001699 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 671143001700 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 671143001701 nucleotide binding region [chemical binding]; other site 671143001702 SEC-C motif; Region: SEC-C; pfam02810 671143001703 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 671143001704 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 671143001705 active site 671143001706 DUF35 OB-fold domain; Region: DUF35; pfam01796 671143001707 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 671143001708 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 671143001709 active site 671143001710 catalytic triad [active] 671143001711 dimer interface [polypeptide binding]; other site 671143001712 Uncharacterized conserved protein [Function unknown]; Region: COG4198 671143001713 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 671143001714 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 671143001715 Pup-like protein; Region: Pup; cl05289 671143001716 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 671143001717 MPT binding site; other site 671143001718 trimer interface [polypeptide binding]; other site 671143001719 GTP cyclohydrolase I; Provisional; Region: PLN03044 671143001720 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 671143001721 homodecamer interface [polypeptide binding]; other site 671143001722 active site 671143001723 putative catalytic site residues [active] 671143001724 zinc binding site [ion binding]; other site 671143001725 GTP-CH-I/GFRP interaction surface; other site 671143001726 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 671143001727 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 671143001728 active site 671143001729 ADP/pyrophosphate binding site [chemical binding]; other site 671143001730 dimerization interface [polypeptide binding]; other site 671143001731 allosteric effector site; other site 671143001732 fructose-1,6-bisphosphate binding site; other site 671143001733 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 671143001734 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 671143001735 active site 671143001736 NTP binding site [chemical binding]; other site 671143001737 metal binding triad [ion binding]; metal-binding site 671143001738 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 671143001739 HD domain; Region: HD; pfam01966 671143001740 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 671143001741 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 671143001742 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 671143001743 serine O-acetyltransferase; Region: cysE; TIGR01172 671143001744 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 671143001745 trimer interface [polypeptide binding]; other site 671143001746 active site 671143001747 substrate binding site [chemical binding]; other site 671143001748 CoA binding site [chemical binding]; other site 671143001749 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 671143001750 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 671143001751 ligand binding site; other site 671143001752 oligomer interface; other site 671143001753 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 671143001754 dimer interface [polypeptide binding]; other site 671143001755 N-terminal domain interface [polypeptide binding]; other site 671143001756 sulfate 1 binding site; other site 671143001757 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 671143001758 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 671143001759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 671143001760 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 671143001761 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 671143001762 malonyl-CoA binding site [chemical binding]; other site 671143001763 dimer interface [polypeptide binding]; other site 671143001764 active site 671143001765 product binding site; other site 671143001766 Methyltransferase domain; Region: Methyltransf_31; pfam13847 671143001767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143001768 S-adenosylmethionine binding site [chemical binding]; other site 671143001769 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 671143001770 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 671143001771 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 671143001772 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 671143001773 lipoyl attachment site [posttranslational modification]; other site 671143001774 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 671143001775 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 671143001776 tetramer interface [polypeptide binding]; other site 671143001777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143001778 catalytic residue [active] 671143001779 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 671143001780 tetramer interface [polypeptide binding]; other site 671143001781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143001782 catalytic residue [active] 671143001783 Uncharacterized conserved protein [Function unknown]; Region: COG1683 671143001784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 671143001785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 671143001786 Uncharacterized conserved protein [Function unknown]; Region: COG2442 671143001787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 671143001788 RelB antitoxin; Region: RelB; cl01171 671143001789 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 671143001790 dimer interface [polypeptide binding]; other site 671143001791 substrate binding site [chemical binding]; other site 671143001792 ATP binding site [chemical binding]; other site 671143001793 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 671143001794 Active_site [active] 671143001795 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 671143001796 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 671143001797 putative NAD(P) binding site [chemical binding]; other site 671143001798 putative active site [active] 671143001799 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 671143001800 active site 671143001801 NTP binding site [chemical binding]; other site 671143001802 metal binding triad [ion binding]; metal-binding site 671143001803 antibiotic binding site [chemical binding]; other site 671143001804 putative transposase OrfB; Reviewed; Region: PHA02517 671143001805 Integrase core domain; Region: rve; pfam00665 671143001806 Integrase core domain; Region: rve_3; pfam13683 671143001807 Protein of unknown function DUF86; Region: DUF86; cl01031 671143001808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 671143001809 active site 671143001810 TIR domain; Region: TIR_2; pfam13676 671143001811 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 671143001812 HSP70 interaction site [polypeptide binding]; other site 671143001813 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 671143001814 Putative addiction module component; Region: Unstab_antitox; pfam09720 671143001815 YcfA-like protein; Region: YcfA; cl00752 671143001816 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 671143001817 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 671143001818 homodimer interface [polypeptide binding]; other site 671143001819 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 671143001820 active site pocket [active] 671143001821 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 671143001822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 671143001823 ATP binding site [chemical binding]; other site 671143001824 Mg2+ binding site [ion binding]; other site 671143001825 G-X-G motif; other site 671143001826 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 671143001827 anti sigma factor interaction site; other site 671143001828 regulatory phosphorylation site [posttranslational modification]; other site 671143001829 Hpt domain; Region: Hpt; pfam01627 671143001830 PAS domain S-box; Region: sensory_box; TIGR00229 671143001831 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143001832 putative active site [active] 671143001833 heme pocket [chemical binding]; other site 671143001834 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143001835 PAS domain; Region: PAS_9; pfam13426 671143001836 putative active site [active] 671143001837 heme pocket [chemical binding]; other site 671143001838 GAF domain; Region: GAF; cl17456 671143001839 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143001840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143001841 dimer interface [polypeptide binding]; other site 671143001842 phosphorylation site [posttranslational modification] 671143001843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143001844 ATP binding site [chemical binding]; other site 671143001845 Mg2+ binding site [ion binding]; other site 671143001846 G-X-G motif; other site 671143001847 Response regulator receiver domain; Region: Response_reg; pfam00072 671143001848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143001849 active site 671143001850 phosphorylation site [posttranslational modification] 671143001851 intermolecular recognition site; other site 671143001852 dimerization interface [polypeptide binding]; other site 671143001853 Response regulator receiver domain; Region: Response_reg; pfam00072 671143001854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143001855 active site 671143001856 phosphorylation site [posttranslational modification] 671143001857 intermolecular recognition site; other site 671143001858 dimerization interface [polypeptide binding]; other site 671143001859 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 671143001860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143001861 active site 671143001862 phosphorylation site [posttranslational modification] 671143001863 intermolecular recognition site; other site 671143001864 dimerization interface [polypeptide binding]; other site 671143001865 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 671143001866 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 671143001867 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 671143001868 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 671143001869 E3 interaction surface; other site 671143001870 lipoyl attachment site [posttranslational modification]; other site 671143001871 e3 binding domain; Region: E3_binding; pfam02817 671143001872 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 671143001873 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 671143001874 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 671143001875 alpha subunit interface [polypeptide binding]; other site 671143001876 TPP binding site [chemical binding]; other site 671143001877 heterodimer interface [polypeptide binding]; other site 671143001878 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 671143001879 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 671143001880 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 671143001881 tetramer interface [polypeptide binding]; other site 671143001882 TPP-binding site [chemical binding]; other site 671143001883 heterodimer interface [polypeptide binding]; other site 671143001884 phosphorylation loop region [posttranslational modification] 671143001885 proteasome ATPase; Region: pup_AAA; TIGR03689 671143001886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143001887 Walker A motif; other site 671143001888 ATP binding site [chemical binding]; other site 671143001889 Walker B motif; other site 671143001890 arginine finger; other site 671143001891 Pup-ligase protein; Region: Pup_ligase; pfam03136 671143001892 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 671143001893 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 671143001894 active site 671143001895 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 671143001896 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 671143001897 active site 671143001898 Pup-ligase protein; Region: Pup_ligase; cl15463 671143001899 multifunctional aminopeptidase A; Provisional; Region: PRK00913 671143001900 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 671143001901 interface (dimer of trimers) [polypeptide binding]; other site 671143001902 Substrate-binding/catalytic site; other site 671143001903 Zn-binding sites [ion binding]; other site 671143001904 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 671143001905 AsnC family; Region: AsnC_trans_reg; pfam01037 671143001906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 671143001907 Major Facilitator Superfamily; Region: MFS_1; pfam07690 671143001908 putative substrate translocation pore; other site 671143001909 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 671143001910 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143001911 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001912 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143001913 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001914 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143001915 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001916 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001917 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143001918 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143001919 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001920 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001921 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143001922 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001923 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143001924 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001925 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001926 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001927 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143001928 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001929 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143001930 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001931 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001932 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001933 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143001934 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001935 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143001936 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001937 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001938 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001939 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143001940 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143001941 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001942 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143001943 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143001944 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 671143001945 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 671143001946 4Fe-4S binding domain; Region: Fer4; pfam00037 671143001947 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 671143001948 iron-sulfur cluster [ion binding]; other site 671143001949 [2Fe-2S] cluster binding site [ion binding]; other site 671143001950 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 671143001951 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 671143001952 interchain domain interface [polypeptide binding]; other site 671143001953 intrachain domain interface; other site 671143001954 heme bH binding site [chemical binding]; other site 671143001955 Qi binding site; other site 671143001956 heme bL binding site [chemical binding]; other site 671143001957 Qo binding site; other site 671143001958 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 671143001959 PemK-like protein; Region: PemK; pfam02452 671143001960 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 671143001961 Protein of unknown function (DUF497); Region: DUF497; pfam04365 671143001962 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 671143001963 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 671143001964 gating phenylalanine in ion channel; other site 671143001965 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 671143001966 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 671143001967 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 671143001968 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 671143001969 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 671143001970 [4Fe-4S] binding site [ion binding]; other site 671143001971 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 671143001972 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 671143001973 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 671143001974 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 671143001975 molybdopterin cofactor binding site; other site 671143001976 Cytochrome c; Region: Cytochrom_C; pfam00034 671143001977 Cytochrome c; Region: Cytochrom_C; pfam00034 671143001978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 671143001979 Walker B; other site 671143001980 D-loop; other site 671143001981 H-loop/switch region; other site 671143001982 Transposase [DNA replication, recombination, and repair]; Region: COG5421 671143001983 Transposase [DNA replication, recombination, and repair]; Region: COG5421 671143001984 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 671143001985 putative active site [active] 671143001986 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 671143001987 AAA domain; Region: AAA_14; pfam13173 671143001988 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 671143001989 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 671143001990 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 671143001991 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 671143001992 Low-spin heme binding site [chemical binding]; other site 671143001993 D-pathway; other site 671143001994 Putative water exit pathway; other site 671143001995 Binuclear center (active site) [active] 671143001996 K-pathway; other site 671143001997 Putative proton exit pathway; other site 671143001998 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 671143001999 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 671143002000 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 671143002001 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 671143002002 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 671143002003 putative dimerization interface [polypeptide binding]; other site 671143002004 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 671143002005 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 671143002006 AsmA family; Region: AsmA; pfam05170 671143002007 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 671143002008 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 671143002009 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 671143002010 GatB domain; Region: GatB_Yqey; smart00845 671143002011 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 671143002012 putative active site pocket [active] 671143002013 dimerization interface [polypeptide binding]; other site 671143002014 putative catalytic residue [active] 671143002015 Ras GTPase Activating Domain; Region: RasGAP; cl02569 671143002016 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 671143002017 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 671143002018 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 671143002019 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 671143002020 Part of AAA domain; Region: AAA_19; pfam13245 671143002021 Family description; Region: UvrD_C_2; pfam13538 671143002022 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 671143002023 oligomeric interface; other site 671143002024 putative active site [active] 671143002025 homodimer interface [polypeptide binding]; other site 671143002026 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 671143002027 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 671143002028 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 671143002029 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 671143002030 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 671143002031 iron-sulfur cluster [ion binding]; other site 671143002032 [2Fe-2S] cluster binding site [ion binding]; other site 671143002033 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 671143002034 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 671143002035 heme bH binding site [chemical binding]; other site 671143002036 intrachain domain interface; other site 671143002037 Qi binding site; other site 671143002038 heme bL binding site [chemical binding]; other site 671143002039 interchain domain interface [polypeptide binding]; other site 671143002040 Qo binding site; other site 671143002041 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 671143002042 intrachain domain interface; other site 671143002043 Qi binding site; other site 671143002044 Qo binding site; other site 671143002045 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 671143002046 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 671143002047 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 671143002048 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 671143002049 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 671143002050 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 671143002051 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 671143002052 heme-binding residues [chemical binding]; other site 671143002053 TPR repeat; Region: TPR_11; pfam13414 671143002054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143002055 TPR motif; other site 671143002056 TPR repeat; Region: TPR_11; pfam13414 671143002057 binding surface 671143002058 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 671143002059 B1 nucleotide binding pocket [chemical binding]; other site 671143002060 B2 nucleotide binding pocket [chemical binding]; other site 671143002061 CAS motifs; other site 671143002062 active site 671143002063 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 671143002064 PGAP1-like protein; Region: PGAP1; pfam07819 671143002065 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 671143002066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 671143002067 binding surface 671143002068 TPR motif; other site 671143002069 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 671143002070 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 671143002071 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 671143002072 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 671143002073 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 671143002074 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 671143002075 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 671143002076 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 671143002077 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 671143002078 Walker A/P-loop; other site 671143002079 ATP binding site [chemical binding]; other site 671143002080 Q-loop/lid; other site 671143002081 ABC transporter signature motif; other site 671143002082 Walker B; other site 671143002083 D-loop; other site 671143002084 H-loop/switch region; other site 671143002085 DDE domain; Region: DDE_Tnp_IS240; pfam13610 671143002086 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 671143002087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143002088 salt bridge; other site 671143002089 non-specific DNA binding site [nucleotide binding]; other site 671143002090 sequence-specific DNA binding site [nucleotide binding]; other site 671143002091 Domain of unknown function (DUF955); Region: DUF955; cl01076 671143002092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143002093 non-specific DNA binding site [nucleotide binding]; other site 671143002094 salt bridge; other site 671143002095 sequence-specific DNA binding site [nucleotide binding]; other site 671143002096 Type II restriction enzyme MunI; Region: RestrictionMunI; pfam11407 671143002097 MT-A70; Region: MT-A70; cl01947 671143002098 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 671143002099 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 671143002100 RNB domain; Region: RNB; pfam00773 671143002101 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 671143002102 RNA binding site [nucleotide binding]; other site 671143002103 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 671143002104 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 671143002105 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 671143002106 catalytic loop [active] 671143002107 iron binding site [ion binding]; other site 671143002108 4Fe-4S binding domain; Region: Fer4; pfam00037 671143002109 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 671143002110 [4Fe-4S] binding site [ion binding]; other site 671143002111 molybdopterin cofactor binding site; other site 671143002112 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 671143002113 molybdopterin cofactor binding site; other site 671143002114 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 671143002115 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 671143002116 putative dimer interface [polypeptide binding]; other site 671143002117 [2Fe-2S] cluster binding site [ion binding]; other site 671143002118 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 671143002119 dimer interface [polypeptide binding]; other site 671143002120 [2Fe-2S] cluster binding site [ion binding]; other site 671143002121 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 671143002122 SLBB domain; Region: SLBB; pfam10531 671143002123 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 671143002124 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 671143002125 AsnC family; Region: AsnC_trans_reg; pfam01037 671143002126 Helix-turn-helix domain; Region: HTH_17; pfam12728 671143002127 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 671143002128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143002129 putative active site [active] 671143002130 heme pocket [chemical binding]; other site 671143002131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143002132 phosphorylation site [posttranslational modification] 671143002133 dimer interface [polypeptide binding]; other site 671143002134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143002135 ATP binding site [chemical binding]; other site 671143002136 Mg2+ binding site [ion binding]; other site 671143002137 G-X-G motif; other site 671143002138 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143002139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143002140 active site 671143002141 phosphorylation site [posttranslational modification] 671143002142 intermolecular recognition site; other site 671143002143 dimerization interface [polypeptide binding]; other site 671143002144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143002145 Walker A motif; other site 671143002146 ATP binding site [chemical binding]; other site 671143002147 Walker B motif; other site 671143002148 arginine finger; other site 671143002149 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 671143002150 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 671143002151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 671143002152 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 671143002153 putative dimerization interface [polypeptide binding]; other site 671143002154 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 671143002155 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 671143002156 ATP binding site [chemical binding]; other site 671143002157 active site 671143002158 substrate binding site [chemical binding]; other site 671143002159 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 671143002160 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 671143002161 iron-sulfur cluster [ion binding]; other site 671143002162 [2Fe-2S] cluster binding site [ion binding]; other site 671143002163 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 671143002164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 671143002165 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 671143002166 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 671143002167 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 671143002168 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 671143002169 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 671143002170 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 671143002171 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 671143002172 active site 671143002173 dimer interface [polypeptide binding]; other site 671143002174 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 671143002175 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 671143002176 active site 671143002177 FMN binding site [chemical binding]; other site 671143002178 substrate binding site [chemical binding]; other site 671143002179 3Fe-4S cluster binding site [ion binding]; other site 671143002180 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 671143002181 domain interface; other site 671143002182 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 671143002183 Transglycosylase; Region: Transgly; pfam00912 671143002184 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 671143002185 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 671143002186 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 671143002187 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 671143002188 substrate binding site [chemical binding]; other site 671143002189 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 671143002190 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 671143002191 substrate binding site [chemical binding]; other site 671143002192 ligand binding site [chemical binding]; other site 671143002193 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 671143002194 pteridine reductase; Provisional; Region: PRK09135 671143002195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 671143002196 NAD(P) binding site [chemical binding]; other site 671143002197 active site 671143002198 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 671143002199 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 671143002200 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 671143002201 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 671143002202 DNA binding site [nucleotide binding] 671143002203 active site 671143002204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143002205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143002206 active site 671143002207 phosphorylation site [posttranslational modification] 671143002208 intermolecular recognition site; other site 671143002209 dimerization interface [polypeptide binding]; other site 671143002210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143002211 Walker A motif; other site 671143002212 ATP binding site [chemical binding]; other site 671143002213 Walker B motif; other site 671143002214 arginine finger; other site 671143002215 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143002216 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 671143002217 active site 671143002218 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 671143002219 TPR repeat; Region: TPR_11; pfam13414 671143002220 binding surface 671143002221 TPR motif; other site 671143002222 Peptidase family M48; Region: Peptidase_M48; pfam01435 671143002223 Base plate wedge protein 53; Region: Phage_gp53; cl17643 671143002224 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 671143002225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143002226 S-adenosylmethionine binding site [chemical binding]; other site 671143002227 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 671143002228 UbiA prenyltransferase family; Region: UbiA; pfam01040 671143002229 Conjugative transposon protein TraO; Region: TraO; pfam10626 671143002230 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 671143002231 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 671143002232 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 671143002233 active site 671143002234 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 671143002235 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 671143002236 metal-binding site 671143002237 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 671143002238 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 671143002239 Walker A/P-loop; other site 671143002240 ATP binding site [chemical binding]; other site 671143002241 Q-loop/lid; other site 671143002242 ABC transporter signature motif; other site 671143002243 Walker B; other site 671143002244 D-loop; other site 671143002245 H-loop/switch region; other site 671143002246 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 671143002247 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 671143002248 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 671143002249 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 671143002250 NADP-binding site; other site 671143002251 homotetramer interface [polypeptide binding]; other site 671143002252 substrate binding site [chemical binding]; other site 671143002253 homodimer interface [polypeptide binding]; other site 671143002254 active site 671143002255 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 671143002256 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 671143002257 active site 671143002258 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 671143002259 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 671143002260 NADP binding site [chemical binding]; other site 671143002261 active site 671143002262 putative substrate binding site [chemical binding]; other site 671143002263 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 671143002264 active site 671143002265 NTP binding site [chemical binding]; other site 671143002266 metal binding triad [ion binding]; metal-binding site 671143002267 antibiotic binding site [chemical binding]; other site 671143002268 Uncharacterized conserved protein [Function unknown]; Region: COG2445 671143002269 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 671143002270 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 671143002271 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 671143002272 GSCFA family; Region: GSCFA; pfam08885 671143002273 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 671143002274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143002275 FeS/SAM binding site; other site 671143002276 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 671143002277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 671143002278 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 671143002279 YcfA-like protein; Region: YcfA; pfam07927 671143002280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 671143002281 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 671143002282 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 671143002283 active site 671143002284 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 671143002285 ligand-binding site [chemical binding]; other site 671143002286 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 671143002287 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 671143002288 metal-binding site 671143002289 Methyltransferase domain; Region: Methyltransf_23; pfam13489 671143002290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143002291 S-adenosylmethionine binding site [chemical binding]; other site 671143002292 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 671143002293 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 671143002294 Ligand binding site; other site 671143002295 Putative Catalytic site; other site 671143002296 DXD motif; other site 671143002297 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 671143002298 UDP-glucose 4 epimerase, subgroup 2, extended (e) SDRs; Region: UDP_G4E_2_SDR_e; cd05234 671143002299 NAD binding site [chemical binding]; other site 671143002300 homodimer interface [polypeptide binding]; other site 671143002301 active site 671143002302 putative substrate binding site [chemical binding]; other site 671143002303 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 671143002304 classical (c) SDRs; Region: SDR_c; cd05233 671143002305 NAD(P) binding site [chemical binding]; other site 671143002306 active site 671143002307 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 671143002308 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 671143002309 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 671143002310 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 671143002311 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 671143002312 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 671143002313 Substrate binding site; other site 671143002314 Mg++ binding site; other site 671143002315 metal-binding site 671143002316 Mg++ binding site; other site 671143002317 metal-binding site 671143002318 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 671143002319 dimer interface [polypeptide binding]; other site 671143002320 active site 671143002321 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 671143002322 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 671143002323 active site 671143002324 motif I; other site 671143002325 motif II; other site 671143002326 putative translaldolase; Provisional; Region: PRK12376 671143002327 catalytic residue [active] 671143002328 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 671143002329 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 671143002330 NADP-binding site; other site 671143002331 homotetramer interface [polypeptide binding]; other site 671143002332 substrate binding site [chemical binding]; other site 671143002333 homodimer interface [polypeptide binding]; other site 671143002334 active site 671143002335 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 671143002336 putative active site [active] 671143002337 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 671143002338 putative active site [active] 671143002339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 671143002340 Major Facilitator Superfamily; Region: MFS_1; pfam07690 671143002341 putative substrate translocation pore; other site 671143002342 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 671143002343 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 671143002344 FOG: CBS domain [General function prediction only]; Region: COG0517 671143002345 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 671143002346 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 671143002347 HEPN domain; Region: HEPN; pfam05168 671143002348 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 671143002349 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 671143002350 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 671143002351 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 671143002352 HlyD family secretion protein; Region: HlyD_3; pfam13437 671143002353 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 671143002354 Integral membrane protein TerC family; Region: TerC; cl10468 671143002355 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 671143002356 Peptidase family M50; Region: Peptidase_M50; pfam02163 671143002357 active site 671143002358 putative substrate binding region [chemical binding]; other site 671143002359 FOG: CBS domain [General function prediction only]; Region: COG0517 671143002360 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 671143002361 YHS domain; Region: YHS; pfam04945 671143002362 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 671143002363 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 671143002364 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 671143002365 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 671143002366 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 671143002367 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 671143002368 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 671143002369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143002370 Walker A motif; other site 671143002371 ATP binding site [chemical binding]; other site 671143002372 Walker B motif; other site 671143002373 arginine finger; other site 671143002374 Peptidase family M41; Region: Peptidase_M41; pfam01434 671143002375 Response regulator receiver domain; Region: Response_reg; pfam00072 671143002376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143002377 active site 671143002378 phosphorylation site [posttranslational modification] 671143002379 intermolecular recognition site; other site 671143002380 dimerization interface [polypeptide binding]; other site 671143002381 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143002382 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 671143002383 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143002384 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143002385 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143002386 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143002387 FOG: CBS domain [General function prediction only]; Region: COG0517 671143002388 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 671143002389 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 671143002390 dimer interface [polypeptide binding]; other site 671143002391 PYR/PP interface [polypeptide binding]; other site 671143002392 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 671143002393 TPP binding site [chemical binding]; other site 671143002394 substrate binding site [chemical binding]; other site 671143002395 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 671143002396 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 671143002397 pyuvate ferredoxin oxidoreductase subunit delta; Reviewed; Region: porD; PRK09624 671143002398 4Fe-4S binding domain; Region: Fer4_6; pfam12837 671143002399 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 671143002400 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 671143002401 Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018 671143002402 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 671143002403 TPP-binding site [chemical binding]; other site 671143002404 dimer interface [polypeptide binding]; other site 671143002405 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 671143002406 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143002407 FeS/SAM binding site; other site 671143002408 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 671143002409 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 671143002410 Ligand Binding Site [chemical binding]; other site 671143002411 Phosphotransferase enzyme family; Region: APH; pfam01636 671143002412 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 671143002413 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 671143002414 active site 671143002415 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 671143002416 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 671143002417 putative dimer interface [polypeptide binding]; other site 671143002418 S-adenosylmethionine synthetase; Provisional; Region: PRK04439 671143002419 FOG: CBS domain [General function prediction only]; Region: COG0517 671143002420 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 671143002421 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 671143002422 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 671143002423 Ligand Binding Site [chemical binding]; other site 671143002424 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 671143002425 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 671143002426 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 671143002427 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 671143002428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 671143002429 motif II; other site 671143002430 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 671143002431 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 671143002432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 671143002433 Coenzyme A binding pocket [chemical binding]; other site 671143002434 AAA domain; Region: AAA_32; pfam13654 671143002435 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 671143002436 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 671143002437 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 671143002438 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 671143002439 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 671143002440 putative dimer interface [polypeptide binding]; other site 671143002441 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 671143002442 putative deacylase active site [active] 671143002443 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 671143002444 putative transposase OrfB; Reviewed; Region: PHA02517 671143002445 HTH-like domain; Region: HTH_21; pfam13276 671143002446 Integrase core domain; Region: rve; pfam00665 671143002447 Integrase core domain; Region: rve_3; pfam13683 671143002448 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 671143002449 Sel1-like repeats; Region: SEL1; smart00671 671143002450 Sel1-like repeats; Region: SEL1; smart00671 671143002451 Sel1-like repeats; Region: SEL1; smart00671 671143002452 Sel1 repeat; Region: Sel1; pfam08238 671143002453 Sel1 repeat; Region: Sel1; cl02723 671143002454 putative transposase OrfB; Reviewed; Region: PHA02517 671143002455 Integrase core domain; Region: rve; pfam00665 671143002456 Integrase core domain; Region: rve_3; pfam13683 671143002457 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 671143002458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143002459 non-specific DNA binding site [nucleotide binding]; other site 671143002460 salt bridge; other site 671143002461 sequence-specific DNA binding site [nucleotide binding]; other site 671143002462 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 671143002463 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 671143002464 Cell division protein 48 (CDC48) domain 2; Region: CDC48_2; smart01072 671143002465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143002466 Walker A motif; other site 671143002467 ATP binding site [chemical binding]; other site 671143002468 Walker B motif; other site 671143002469 arginine finger; other site 671143002470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143002471 Walker A motif; other site 671143002472 ATP binding site [chemical binding]; other site 671143002473 Walker B motif; other site 671143002474 arginine finger; other site 671143002475 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 671143002476 active site 671143002477 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 671143002478 Ligand Binding Site [chemical binding]; other site 671143002479 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 671143002480 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 671143002481 active site residue [active] 671143002482 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 671143002483 active site residue [active] 671143002484 ADP-glucose phosphorylase; Region: PLN02643 671143002485 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 671143002486 nucleotide binding site/active site [active] 671143002487 HIT family signature motif; other site 671143002488 catalytic residue [active] 671143002489 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 671143002490 Isochorismatase family; Region: Isochorismatase; pfam00857 671143002491 catalytic triad [active] 671143002492 metal binding site [ion binding]; metal-binding site 671143002493 conserved cis-peptide bond; other site 671143002494 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 671143002495 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 671143002496 active site 671143002497 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 671143002498 active site clefts [active] 671143002499 zinc binding site [ion binding]; other site 671143002500 dimer interface [polypeptide binding]; other site 671143002501 Predicted transcriptional regulator [Transcription]; Region: COG1959 671143002502 Transcriptional regulator; Region: Rrf2; pfam02082 671143002503 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 671143002504 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 671143002505 dimer interface [polypeptide binding]; other site 671143002506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143002507 catalytic residue [active] 671143002508 Molybdopterin converting factor, small subunit [Coenzyme metabolism]; Region: MoaD; COG1977 671143002509 charged pocket; other site 671143002510 hydrophobic patch; other site 671143002511 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 671143002512 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 671143002513 ATP binding site [chemical binding]; other site 671143002514 substrate interface [chemical binding]; other site 671143002515 Sulphur transport; Region: Sulf_transp; pfam04143 671143002516 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 671143002517 CPxP motif; other site 671143002518 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 671143002519 CPxP motif; other site 671143002520 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 671143002521 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 671143002522 dimer interface [polypeptide binding]; other site 671143002523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143002524 catalytic residue [active] 671143002525 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 671143002526 MPN+ (JAMM) motif; other site 671143002527 Zinc-binding site [ion binding]; other site 671143002528 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 671143002529 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 671143002530 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 671143002531 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 671143002532 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 671143002533 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143002534 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143002535 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143002536 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143002537 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143002538 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143002539 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 671143002540 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 671143002541 Active Sites [active] 671143002542 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 671143002543 ATP-sulfurylase; Region: ATPS; cd00517 671143002544 active site 671143002545 HXXH motif; other site 671143002546 flexible loop; other site 671143002547 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 671143002548 active site residue [active] 671143002549 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 671143002550 active site residue [active] 671143002551 NIL domain; Region: NIL; pfam09383 671143002552 NIL domain; Region: NIL; cl09633 671143002553 threonine synthase; Validated; Region: PRK07591 671143002554 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 671143002555 homodimer interface [polypeptide binding]; other site 671143002556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143002557 catalytic residue [active] 671143002558 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 671143002559 MoaE interaction surface [polypeptide binding]; other site 671143002560 MoeB interaction surface [polypeptide binding]; other site 671143002561 thiocarboxylated glycine; other site 671143002562 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 671143002563 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 671143002564 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 671143002565 ACT domain-containing protein [General function prediction only]; Region: COG4747 671143002566 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 671143002567 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 671143002568 putative active site [active] 671143002569 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 671143002570 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 671143002571 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 671143002572 ADP-glucose phosphorylase; Region: PLN02643 671143002573 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 671143002574 dimer interface [polypeptide binding]; other site 671143002575 active site 671143002576 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 671143002577 Nitrogen regulatory protein P-II; Region: P-II; smart00938 671143002578 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 671143002579 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 671143002580 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 671143002581 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 671143002582 metal binding triad; other site 671143002583 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 671143002584 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 671143002585 metal binding triad; other site 671143002586 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 671143002587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 671143002588 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 671143002589 NAD(P) binding site [chemical binding]; other site 671143002590 active site 671143002591 Membrane protein of unknown function; Region: DUF360; pfam04020 671143002592 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 671143002593 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 671143002594 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 671143002595 acyl-activating enzyme (AAE) consensus motif; other site 671143002596 active site 671143002597 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 671143002598 putative active site [active] 671143002599 putative catalytic site [active] 671143002600 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 671143002601 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 671143002602 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 671143002603 putative active site [active] 671143002604 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 671143002605 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 671143002606 Clp amino terminal domain; Region: Clp_N; pfam02861 671143002607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143002608 Walker A motif; other site 671143002609 ATP binding site [chemical binding]; other site 671143002610 Walker B motif; other site 671143002611 arginine finger; other site 671143002612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143002613 Walker A motif; other site 671143002614 ATP binding site [chemical binding]; other site 671143002615 Walker B motif; other site 671143002616 arginine finger; other site 671143002617 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 671143002618 Evidence 4 : Homologs of previously reported genes of unknown function 671143002619 Evidence 4 : Homologs of previously reported genes of unknown function 671143002620 Peptidase family M48; Region: Peptidase_M48; pfam01435 671143002621 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 671143002622 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 671143002623 dimer interface [polypeptide binding]; other site 671143002624 active site 671143002625 glycine-pyridoxal phosphate binding site [chemical binding]; other site 671143002626 folate binding site [chemical binding]; other site 671143002627 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 671143002628 ATP cone domain; Region: ATP-cone; pfam03477 671143002629 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 671143002630 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 671143002631 tRNA; other site 671143002632 putative tRNA binding site [nucleotide binding]; other site 671143002633 putative NADP binding site [chemical binding]; other site 671143002634 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 671143002635 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 671143002636 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 671143002637 domain interfaces; other site 671143002638 active site 671143002639 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 671143002640 active site 671143002641 SAM binding site [chemical binding]; other site 671143002642 homodimer interface [polypeptide binding]; other site 671143002643 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 671143002644 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 671143002645 active site 671143002646 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 671143002647 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 671143002648 active site 671143002649 dimer interface [polypeptide binding]; other site 671143002650 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 671143002651 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 671143002652 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 671143002653 Flavoprotein; Region: Flavoprotein; pfam02441 671143002654 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 671143002655 TolR protein; Region: tolR; TIGR02801 671143002656 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 671143002657 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 671143002658 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 671143002659 twin arginine translocase protein A; Provisional; Region: tatA; PRK14858 671143002660 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 671143002661 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 671143002662 PhoU domain; Region: PhoU; pfam01895 671143002663 PhoU domain; Region: PhoU; pfam01895 671143002664 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 671143002665 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 671143002666 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 671143002667 Walker A/P-loop; other site 671143002668 ATP binding site [chemical binding]; other site 671143002669 Q-loop/lid; other site 671143002670 ABC transporter signature motif; other site 671143002671 Walker B; other site 671143002672 D-loop; other site 671143002673 H-loop/switch region; other site 671143002674 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 671143002675 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 671143002676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 671143002677 dimer interface [polypeptide binding]; other site 671143002678 conserved gate region; other site 671143002679 putative PBP binding loops; other site 671143002680 ABC-ATPase subunit interface; other site 671143002681 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 671143002682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 671143002683 ABC-ATPase subunit interface; other site 671143002684 PBP superfamily domain; Region: PBP_like_2; cl17296 671143002685 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 671143002686 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 671143002687 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 671143002688 anti sigma factor interaction site; other site 671143002689 regulatory phosphorylation site [posttranslational modification]; other site 671143002690 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 671143002691 S-adenosylmethionine synthetase; Validated; Region: PRK05250 671143002692 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 671143002693 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 671143002694 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 671143002695 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 671143002696 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 671143002697 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 671143002698 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 671143002699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 671143002700 motif II; other site 671143002701 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 671143002702 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 671143002703 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 671143002704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143002705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143002706 dimer interface [polypeptide binding]; other site 671143002707 phosphorylation site [posttranslational modification] 671143002708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143002709 ATP binding site [chemical binding]; other site 671143002710 Mg2+ binding site [ion binding]; other site 671143002711 G-X-G motif; other site 671143002712 Response regulator receiver domain; Region: Response_reg; pfam00072 671143002713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143002714 active site 671143002715 phosphorylation site [posttranslational modification] 671143002716 intermolecular recognition site; other site 671143002717 dimerization interface [polypeptide binding]; other site 671143002718 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 671143002719 active site 671143002720 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 671143002721 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 671143002722 D-pathway; other site 671143002723 Low-spin heme binding site [chemical binding]; other site 671143002724 Putative water exit pathway; other site 671143002725 Binuclear center (active site) [active] 671143002726 K-pathway; other site 671143002727 Putative proton exit pathway; other site 671143002728 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 671143002729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 671143002730 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 671143002731 active site 671143002732 NTP binding site [chemical binding]; other site 671143002733 metal binding triad [ion binding]; metal-binding site 671143002734 antibiotic binding site [chemical binding]; other site 671143002735 HEPN domain; Region: HEPN; pfam05168 671143002736 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 671143002737 Low molecular weight phosphatase family; Region: LMWPc; cd00115 671143002738 active site 671143002739 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 671143002740 arsenical-resistance protein; Region: acr3; TIGR00832 671143002741 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 671143002742 dimerization interface [polypeptide binding]; other site 671143002743 putative DNA binding site [nucleotide binding]; other site 671143002744 putative Zn2+ binding site [ion binding]; other site 671143002745 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 671143002746 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 671143002747 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 671143002748 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 671143002749 RNA binding site [nucleotide binding]; other site 671143002750 Phosphotransferase enzyme family; Region: APH; pfam01636 671143002751 Ecdysteroid kinase; Region: EcKinase; cl17738 671143002752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143002753 dimerization interface [polypeptide binding]; other site 671143002754 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 671143002755 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143002756 putative active site [active] 671143002757 heme pocket [chemical binding]; other site 671143002758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143002759 dimer interface [polypeptide binding]; other site 671143002760 phosphorylation site [posttranslational modification] 671143002761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143002762 ATP binding site [chemical binding]; other site 671143002763 Mg2+ binding site [ion binding]; other site 671143002764 G-X-G motif; other site 671143002765 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 671143002766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143002767 active site 671143002768 phosphorylation site [posttranslational modification] 671143002769 intermolecular recognition site; other site 671143002770 dimerization interface [polypeptide binding]; other site 671143002771 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 671143002772 DNA binding site [nucleotide binding] 671143002773 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 671143002774 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 671143002775 PBP superfamily domain; Region: PBP_like_2; pfam12849 671143002776 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 671143002777 Protein of unknown function (DUF904); Region: DUF904; pfam06005 671143002778 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 671143002779 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 671143002780 molybdopterin cofactor binding site; other site 671143002781 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 671143002782 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 671143002783 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 671143002784 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 671143002785 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 671143002786 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 671143002787 catalytic loop [active] 671143002788 iron binding site [ion binding]; other site 671143002789 4Fe-4S binding domain; Region: Fer4; pfam00037 671143002790 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 671143002791 [4Fe-4S] binding site [ion binding]; other site 671143002792 molybdopterin cofactor binding site; other site 671143002793 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 671143002794 molybdopterin cofactor binding site; other site 671143002795 DsrE/DsrF-like family; Region: DrsE; pfam02635 671143002796 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 671143002797 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 671143002798 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 671143002799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 671143002800 dimer interface [polypeptide binding]; other site 671143002801 conserved gate region; other site 671143002802 putative PBP binding loops; other site 671143002803 ABC-ATPase subunit interface; other site 671143002804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 671143002805 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 671143002806 Walker A/P-loop; other site 671143002807 ATP binding site [chemical binding]; other site 671143002808 Q-loop/lid; other site 671143002809 ABC transporter signature motif; other site 671143002810 Walker B; other site 671143002811 D-loop; other site 671143002812 H-loop/switch region; other site 671143002813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 671143002814 dimer interface [polypeptide binding]; other site 671143002815 conserved gate region; other site 671143002816 putative PBP binding loops; other site 671143002817 ABC-ATPase subunit interface; other site 671143002818 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 671143002819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 671143002820 Walker A/P-loop; other site 671143002821 ATP binding site [chemical binding]; other site 671143002822 Q-loop/lid; other site 671143002823 ABC transporter signature motif; other site 671143002824 Walker B; other site 671143002825 D-loop; other site 671143002826 H-loop/switch region; other site 671143002827 TOBE domain; Region: TOBE; cl01440 671143002828 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 671143002829 trimer interface [polypeptide binding]; other site 671143002830 dimer interface [polypeptide binding]; other site 671143002831 putative active site [active] 671143002832 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 671143002833 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 671143002834 active site 671143002835 Zn binding site [ion binding]; other site 671143002836 Probable zinc-binding domain; Region: zf-trcl; pfam13451 671143002837 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 671143002838 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 671143002839 metal binding site [ion binding]; metal-binding site 671143002840 active site 671143002841 I-site; other site 671143002842 putative transposase OrfB; Reviewed; Region: PHA02517 671143002843 HTH-like domain; Region: HTH_21; pfam13276 671143002844 Integrase core domain; Region: rve; pfam00665 671143002845 Integrase core domain; Region: rve_3; pfam13683 671143002846 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 671143002847 selenocysteine synthase; Provisional; Region: PRK04311 671143002848 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 671143002849 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 671143002850 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 671143002851 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 671143002852 TMP-binding site; other site 671143002853 ATP-binding site [chemical binding]; other site 671143002854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 671143002855 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 671143002856 Walker A motif; other site 671143002857 ATP binding site [chemical binding]; other site 671143002858 DNA polymerase III subunit delta'; Validated; Region: PRK08485 671143002859 PSP1 C-terminal conserved region; Region: PSP1; cl00770 671143002860 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 671143002861 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 671143002862 active site 671143002863 HIGH motif; other site 671143002864 KMSKS motif; other site 671143002865 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 671143002866 anticodon binding site; other site 671143002867 tRNA binding surface [nucleotide binding]; other site 671143002868 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 671143002869 dimer interface [polypeptide binding]; other site 671143002870 putative tRNA-binding site [nucleotide binding]; other site 671143002871 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 671143002872 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 671143002873 active site 671143002874 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 671143002875 hydroxyglutarate oxidase; Provisional; Region: PRK11728 671143002876 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 671143002877 Subunit I/III interface [polypeptide binding]; other site 671143002878 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 671143002879 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 671143002880 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 671143002881 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 671143002882 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 671143002883 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 671143002884 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 671143002885 Mechanosensitive ion channel; Region: MS_channel; pfam00924 671143002886 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 671143002887 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 671143002888 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 671143002889 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 671143002890 Restriction endonuclease; Region: Mrr_cat; pfam04471 671143002891 Tetratricopeptide repeat; Region: TPR_12; pfam13424 671143002892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143002893 binding surface 671143002894 TPR motif; other site 671143002895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143002896 TPR motif; other site 671143002897 binding surface 671143002898 TPR repeat; Region: TPR_11; pfam13414 671143002899 TPR repeat; Region: TPR_11; pfam13414 671143002900 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 671143002901 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 671143002902 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 671143002903 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 671143002904 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 671143002905 protein-splicing catalytic site; other site 671143002906 thioester formation/cholesterol transfer; other site 671143002907 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 671143002908 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 671143002909 TSCPD domain; Region: TSCPD; pfam12637 671143002910 Fic family protein [Function unknown]; Region: COG3177 671143002911 Fic/DOC family; Region: Fic; pfam02661 671143002912 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 671143002913 trimer interface [polypeptide binding]; other site 671143002914 active site 671143002915 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 671143002916 putative Zn2+ binding site [ion binding]; other site 671143002917 putative DNA binding site [nucleotide binding]; other site 671143002918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 671143002919 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 671143002920 OstA-like protein; Region: OstA; pfam03968 671143002921 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 671143002922 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 671143002923 Walker A/P-loop; other site 671143002924 ATP binding site [chemical binding]; other site 671143002925 Q-loop/lid; other site 671143002926 ABC transporter signature motif; other site 671143002927 Walker B; other site 671143002928 D-loop; other site 671143002929 H-loop/switch region; other site 671143002930 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 671143002931 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 671143002932 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 671143002933 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 671143002934 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 671143002935 30S subunit binding site; other site 671143002936 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 671143002937 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 671143002938 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 671143002939 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 671143002940 aspartate kinase; Reviewed; Region: PRK06635 671143002941 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 671143002942 putative nucleotide binding site [chemical binding]; other site 671143002943 putative catalytic residues [active] 671143002944 putative Mg ion binding site [ion binding]; other site 671143002945 putative aspartate binding site [chemical binding]; other site 671143002946 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 671143002947 putative allosteric regulatory site; other site 671143002948 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 671143002949 putative allosteric regulatory residue; other site 671143002950 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 671143002951 ScpA/B protein; Region: ScpA_ScpB; cl00598 671143002952 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 671143002953 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 671143002954 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 671143002955 RNA binding surface [nucleotide binding]; other site 671143002956 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 671143002957 active site 671143002958 Chorismate mutase type II; Region: CM_2; smart00830 671143002959 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 671143002960 Prephenate dehydratase; Region: PDT; pfam00800 671143002961 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 671143002962 putative L-Phe binding site [chemical binding]; other site 671143002963 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 671143002964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 671143002965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143002966 homodimer interface [polypeptide binding]; other site 671143002967 catalytic residue [active] 671143002968 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 671143002969 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 671143002970 prephenate dehydrogenase; Validated; Region: PRK08507 671143002971 Prephenate dehydrogenase; Region: PDH; pfam02153 671143002972 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 671143002973 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 671143002974 HflX GTPase family; Region: HflX; cd01878 671143002975 G1 box; other site 671143002976 GTP/Mg2+ binding site [chemical binding]; other site 671143002977 Switch I region; other site 671143002978 G2 box; other site 671143002979 G3 box; other site 671143002980 Switch II region; other site 671143002981 G4 box; other site 671143002982 G5 box; other site 671143002983 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 671143002984 acetyl-CoA synthetase; Provisional; Region: PRK00174 671143002985 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 671143002986 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 671143002987 acyl-activating enzyme (AAE) consensus motif; other site 671143002988 putative AMP binding site [chemical binding]; other site 671143002989 putative active site [active] 671143002990 putative CoA binding site [chemical binding]; other site 671143002991 GTP-binding protein Der; Reviewed; Region: PRK00093 671143002992 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 671143002993 G1 box; other site 671143002994 GTP/Mg2+ binding site [chemical binding]; other site 671143002995 Switch I region; other site 671143002996 G2 box; other site 671143002997 Switch II region; other site 671143002998 G3 box; other site 671143002999 G4 box; other site 671143003000 G5 box; other site 671143003001 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 671143003002 G1 box; other site 671143003003 GTP/Mg2+ binding site [chemical binding]; other site 671143003004 Switch I region; other site 671143003005 G2 box; other site 671143003006 G3 box; other site 671143003007 Switch II region; other site 671143003008 G4 box; other site 671143003009 G5 box; other site 671143003010 GTP-binding protein YchF; Reviewed; Region: PRK09601 671143003011 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 671143003012 G1 box; other site 671143003013 GTP/Mg2+ binding site [chemical binding]; other site 671143003014 Switch I region; other site 671143003015 G3 box; other site 671143003016 Switch II region; other site 671143003017 G4 box; other site 671143003018 G5 box; other site 671143003019 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 671143003020 RNase_H superfamily; Region: RNase_H_2; pfam13482 671143003021 active site 671143003022 substrate binding site [chemical binding]; other site 671143003023 catalytic site [active] 671143003024 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 671143003025 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 671143003026 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143003027 FeS/SAM binding site; other site 671143003028 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 671143003029 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 671143003030 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 671143003031 substrate binding site [chemical binding]; other site 671143003032 ATP binding site [chemical binding]; other site 671143003033 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 671143003034 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 671143003035 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 671143003036 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 671143003037 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 671143003038 ATP-grasp domain; Region: ATP-grasp_4; cl17255 671143003039 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 671143003040 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 671143003041 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 671143003042 carboxyltransferase (CT) interaction site; other site 671143003043 biotinylation site [posttranslational modification]; other site 671143003044 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 671143003045 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 671143003046 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 671143003047 dimer interface [polypeptide binding]; other site 671143003048 substrate binding site [chemical binding]; other site 671143003049 metal binding site [ion binding]; metal-binding site 671143003050 Family description; Region: VCBS; pfam13517 671143003051 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 671143003052 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 671143003053 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 671143003054 heme binding site [chemical binding]; other site 671143003055 ferroxidase pore; other site 671143003056 ferroxidase diiron center [ion binding]; other site 671143003057 TPR repeat; Region: TPR_11; pfam13414 671143003058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143003059 TPR motif; other site 671143003060 binding surface 671143003061 TPR repeat; Region: TPR_11; pfam13414 671143003062 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 671143003063 MoaE interaction surface [polypeptide binding]; other site 671143003064 MoeB interaction surface [polypeptide binding]; other site 671143003065 thiocarboxylated glycine; other site 671143003066 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 671143003067 MoaE homodimer interface [polypeptide binding]; other site 671143003068 MoaD interaction [polypeptide binding]; other site 671143003069 active site residues [active] 671143003070 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 671143003071 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 671143003072 active site 671143003073 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 671143003074 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 671143003075 dimer interface [polypeptide binding]; other site 671143003076 active site 671143003077 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 671143003078 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 671143003079 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 671143003080 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 671143003081 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 671143003082 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 671143003083 substrate binding site [chemical binding]; other site 671143003084 oxyanion hole (OAH) forming residues; other site 671143003085 trimer interface [polypeptide binding]; other site 671143003086 SEC-C motif; Region: SEC-C; pfam02810 671143003087 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 671143003088 PIN domain; Region: PIN_3; cl17397 671143003089 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 671143003090 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 671143003091 toxin interface [polypeptide binding]; other site 671143003092 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 671143003093 Zn binding site [ion binding]; other site 671143003094 PIN domain; Region: PIN; pfam01850 671143003095 putative active site [active] 671143003096 Uncharacterized conserved protein [Function unknown]; Region: COG1615 671143003097 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 671143003098 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 671143003099 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 671143003100 substrate-cofactor binding pocket; other site 671143003101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143003102 catalytic residue [active] 671143003103 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 671143003104 TrkA-N domain; Region: TrkA_N; pfam02254 671143003105 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 671143003106 catalytic residue [active] 671143003107 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 671143003108 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 671143003109 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 671143003110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 671143003111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 671143003112 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 671143003113 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 671143003114 HlyD family secretion protein; Region: HlyD_3; pfam13437 671143003115 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 671143003116 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 671143003117 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 671143003118 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 671143003119 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 671143003120 N-terminal plug; other site 671143003121 ligand-binding site [chemical binding]; other site 671143003122 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 671143003123 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143003124 dimerization interface [polypeptide binding]; other site 671143003125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143003126 dimer interface [polypeptide binding]; other site 671143003127 phosphorylation site [posttranslational modification] 671143003128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143003129 ATP binding site [chemical binding]; other site 671143003130 Mg2+ binding site [ion binding]; other site 671143003131 G-X-G motif; other site 671143003132 Response regulator receiver domain; Region: Response_reg; pfam00072 671143003133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143003134 active site 671143003135 phosphorylation site [posttranslational modification] 671143003136 intermolecular recognition site; other site 671143003137 dimerization interface [polypeptide binding]; other site 671143003138 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 671143003139 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 671143003140 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 671143003141 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 671143003142 hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367 671143003143 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 671143003144 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143003145 FeS/SAM binding site; other site 671143003146 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 671143003147 hydrophobic ligand binding site; other site 671143003148 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 671143003149 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 671143003150 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 671143003151 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 671143003152 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 671143003153 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 671143003154 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 671143003155 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 671143003156 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 671143003157 Interdomain contacts; other site 671143003158 Cytokine receptor motif; other site 671143003159 Rubrerythrin [Energy production and conversion]; Region: COG1592 671143003160 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 671143003161 binuclear metal center [ion binding]; other site 671143003162 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 671143003163 iron binding site [ion binding]; other site 671143003164 Winged helix-turn helix; Region: HTH_29; pfam13551 671143003165 Homeodomain-like domain; Region: HTH_23; cl17451 671143003166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 671143003167 Integrase core domain; Region: rve; pfam00665 671143003168 Integrase core domain; Region: rve_3; pfam13683 671143003169 integron integrase; Region: integrase_gron; TIGR02249 671143003170 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 671143003171 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 671143003172 putative active site [active] 671143003173 putative PHP Thumb interface [polypeptide binding]; other site 671143003174 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 671143003175 generic binding surface II; other site 671143003176 generic binding surface I; other site 671143003177 DNA Polymerase Y-family; Region: PolY_like; cd03468 671143003178 active site 671143003179 DNA binding site [nucleotide binding] 671143003180 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 671143003181 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 671143003182 Walker A motif; other site 671143003183 ATP binding site [chemical binding]; other site 671143003184 Walker B motif; other site 671143003185 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 671143003186 LexA repressor; Validated; Region: PRK00215 671143003187 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 671143003188 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 671143003189 Catalytic site [active] 671143003190 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143003191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143003192 active site 671143003193 phosphorylation site [posttranslational modification] 671143003194 intermolecular recognition site; other site 671143003195 dimerization interface [polypeptide binding]; other site 671143003196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143003197 Walker A motif; other site 671143003198 ATP binding site [chemical binding]; other site 671143003199 Walker B motif; other site 671143003200 arginine finger; other site 671143003201 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143003202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143003203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143003204 ATP binding site [chemical binding]; other site 671143003205 G-X-G motif; other site 671143003206 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 671143003207 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 671143003208 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 671143003209 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 671143003210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143003211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143003212 dimer interface [polypeptide binding]; other site 671143003213 phosphorylation site [posttranslational modification] 671143003214 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 671143003215 Mg2+ binding site [ion binding]; other site 671143003216 Patatin-like phospholipase; Region: Patatin; pfam01734 671143003217 active site 671143003218 nucleophile elbow; other site 671143003219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143003220 dimer interface [polypeptide binding]; other site 671143003221 phosphorylation site [posttranslational modification] 671143003222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143003223 ATP binding site [chemical binding]; other site 671143003224 Mg2+ binding site [ion binding]; other site 671143003225 G-X-G motif; other site 671143003226 Transposase IS200 like; Region: Y1_Tnp; pfam01797 671143003227 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 671143003228 catalytic site [active] 671143003229 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143003230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143003231 active site 671143003232 phosphorylation site [posttranslational modification] 671143003233 intermolecular recognition site; other site 671143003234 dimerization interface [polypeptide binding]; other site 671143003235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143003236 Walker A motif; other site 671143003237 ATP binding site [chemical binding]; other site 671143003238 Walker B motif; other site 671143003239 arginine finger; other site 671143003240 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143003241 CHASE2 domain; Region: CHASE2; pfam05226 671143003242 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 671143003243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 671143003244 dimer interface [polypeptide binding]; other site 671143003245 phosphorylation site [posttranslational modification] 671143003246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143003247 ATP binding site [chemical binding]; other site 671143003248 Mg2+ binding site [ion binding]; other site 671143003249 G-X-G motif; other site 671143003250 FecR protein; Region: FecR; pfam04773 671143003251 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 671143003252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143003253 TPR motif; other site 671143003254 binding surface 671143003255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143003256 binding surface 671143003257 TPR motif; other site 671143003258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143003259 TPR motif; other site 671143003260 TPR repeat; Region: TPR_11; pfam13414 671143003261 binding surface 671143003262 TPR repeat; Region: TPR_11; pfam13414 671143003263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143003264 binding surface 671143003265 TPR motif; other site 671143003266 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 671143003267 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 671143003268 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 671143003269 DNA binding residues [nucleotide binding] 671143003270 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 671143003271 recombinase A; Provisional; Region: recA; PRK09354 671143003272 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 671143003273 hexamer interface [polypeptide binding]; other site 671143003274 Walker A motif; other site 671143003275 ATP binding site [chemical binding]; other site 671143003276 Walker B motif; other site 671143003277 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 671143003278 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 671143003279 Walker A motif; other site 671143003280 ATP binding site [chemical binding]; other site 671143003281 Walker B motif; other site 671143003282 RecX family; Region: RecX; pfam02631 671143003283 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 671143003284 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 671143003285 motif 1; other site 671143003286 active site 671143003287 motif 2; other site 671143003288 motif 3; other site 671143003289 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 671143003290 DHHA1 domain; Region: DHHA1; pfam02272 671143003291 Type II restriction enzyme SfiI; Region: RestrictionSfiI; pfam11487 671143003292 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 671143003293 DNA methylase; Region: N6_N4_Mtase; cl17433 671143003294 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 671143003295 DNA methylase; Region: N6_N4_Mtase; pfam01555 671143003296 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143003297 sequence-specific DNA binding site [nucleotide binding]; other site 671143003298 salt bridge; other site 671143003299 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 671143003300 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 671143003301 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 671143003302 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 671143003303 2-isopropylmalate synthase; Validated; Region: PRK00915 671143003304 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 671143003305 active site 671143003306 catalytic residues [active] 671143003307 metal binding site [ion binding]; metal-binding site 671143003308 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 671143003309 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 671143003310 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 671143003311 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 671143003312 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 671143003313 dimerization interface 3.5A [polypeptide binding]; other site 671143003314 active site 671143003315 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 671143003316 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 671143003317 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 671143003318 SurA N-terminal domain; Region: SurA_N_3; cl07813 671143003319 Thioredoxin; Region: Thioredoxin_4; pfam13462 671143003320 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 671143003321 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 671143003322 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 671143003323 head completion protein; Provisional; Region: 4; PHA02552 671143003324 Integrase core domain; Region: rve_3; cl15866 671143003325 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 671143003326 HicB family; Region: HicB; pfam05534 671143003327 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 671143003328 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 671143003329 HIGH motif; other site 671143003330 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 671143003331 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 671143003332 active site 671143003333 KMSKS motif; other site 671143003334 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 671143003335 tRNA binding surface [nucleotide binding]; other site 671143003336 Lipopolysaccharide-assembly; Region: LptE; pfam04390 671143003337 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 671143003338 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 671143003339 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 671143003340 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 671143003341 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 671143003342 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 671143003343 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 671143003344 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 671143003345 PYR/PP interface [polypeptide binding]; other site 671143003346 dimer interface [polypeptide binding]; other site 671143003347 TPP binding site [chemical binding]; other site 671143003348 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 671143003349 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 671143003350 TPP-binding site [chemical binding]; other site 671143003351 dimer interface [polypeptide binding]; other site 671143003352 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 671143003353 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 671143003354 putative valine binding site [chemical binding]; other site 671143003355 dimer interface [polypeptide binding]; other site 671143003356 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 671143003357 ketol-acid reductoisomerase; Provisional; Region: PRK05479 671143003358 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 671143003359 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 671143003360 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 671143003361 FAD binding site [chemical binding]; other site 671143003362 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 671143003363 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 671143003364 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 671143003365 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 671143003366 hinge; other site 671143003367 active site 671143003368 cytidylate kinase; Provisional; Region: cmk; PRK00023 671143003369 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 671143003370 CMP-binding site; other site 671143003371 The sites determining sugar specificity; other site 671143003372 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 671143003373 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 671143003374 putative acyl-acceptor binding pocket; other site 671143003375 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 671143003376 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 671143003377 RNA binding site [nucleotide binding]; other site 671143003378 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 671143003379 RNA binding site [nucleotide binding]; other site 671143003380 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 671143003381 RNA binding site [nucleotide binding]; other site 671143003382 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 671143003383 RNA binding site [nucleotide binding]; other site 671143003384 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 671143003385 RNA binding site [nucleotide binding]; other site 671143003386 S1 RNA binding domain; Region: S1; pfam00575 671143003387 RNA binding site [nucleotide binding]; other site 671143003388 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 671143003389 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 671143003390 tandem repeat interface [polypeptide binding]; other site 671143003391 oligomer interface [polypeptide binding]; other site 671143003392 active site residues [active] 671143003393 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 671143003394 IHF - DNA interface [nucleotide binding]; other site 671143003395 IHF dimer interface [polypeptide binding]; other site 671143003396 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 671143003397 nucleotide binding site/active site [active] 671143003398 HIT family signature motif; other site 671143003399 catalytic residue [active] 671143003400 Bifunctional nuclease; Region: DNase-RNase; pfam02577 671143003401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143003402 binding surface 671143003403 TPR motif; other site 671143003404 Tetratricopeptide repeat; Region: TPR_16; pfam13432 671143003405 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 671143003406 active site 671143003407 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 671143003408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143003409 S-adenosylmethionine binding site [chemical binding]; other site 671143003410 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 671143003411 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 671143003412 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 671143003413 DNA binding residues [nucleotide binding] 671143003414 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 671143003415 IHF - DNA interface [nucleotide binding]; other site 671143003416 IHF dimer interface [polypeptide binding]; other site 671143003417 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 671143003418 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 671143003419 substrate binding site [chemical binding]; other site 671143003420 putative active site [active] 671143003421 redox center [active] 671143003422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143003423 FeS/SAM binding site; other site 671143003424 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 671143003425 active site 671143003426 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 671143003427 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 671143003428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143003429 FeS/SAM binding site; other site 671143003430 TRAM domain; Region: TRAM; pfam01938 671143003431 aspartate aminotransferase; Provisional; Region: PRK05764 671143003432 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 671143003433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143003434 homodimer interface [polypeptide binding]; other site 671143003435 catalytic residue [active] 671143003436 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 671143003437 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 671143003438 active site 671143003439 (T/H)XGH motif; other site 671143003440 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 671143003441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143003442 S-adenosylmethionine binding site [chemical binding]; other site 671143003443 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 671143003444 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 671143003445 Zn2+ binding site [ion binding]; other site 671143003446 Mg2+ binding site [ion binding]; other site 671143003447 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 671143003448 synthetase active site [active] 671143003449 NTP binding site [chemical binding]; other site 671143003450 metal binding site [ion binding]; metal-binding site 671143003451 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 671143003452 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 671143003453 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 671143003454 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 671143003455 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 671143003456 dimerization interface [polypeptide binding]; other site 671143003457 ligand binding site [chemical binding]; other site 671143003458 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 671143003459 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 671143003460 Walker A/P-loop; other site 671143003461 ATP binding site [chemical binding]; other site 671143003462 Q-loop/lid; other site 671143003463 ABC transporter signature motif; other site 671143003464 Walker B; other site 671143003465 D-loop; other site 671143003466 H-loop/switch region; other site 671143003467 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 671143003468 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 671143003469 TM-ABC transporter signature motif; other site 671143003470 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 671143003471 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 671143003472 Walker A/P-loop; other site 671143003473 ATP binding site [chemical binding]; other site 671143003474 Q-loop/lid; other site 671143003475 ABC transporter signature motif; other site 671143003476 Walker B; other site 671143003477 D-loop; other site 671143003478 H-loop/switch region; other site 671143003479 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 671143003480 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 671143003481 TM-ABC transporter signature motif; other site 671143003482 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 671143003483 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 671143003484 dimerization interface [polypeptide binding]; other site 671143003485 ligand binding site [chemical binding]; other site 671143003486 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 671143003487 thiamine phosphate binding site [chemical binding]; other site 671143003488 active site 671143003489 pyrophosphate binding site [ion binding]; other site 671143003490 elongation factor P; Validated; Region: PRK00529 671143003491 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 671143003492 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 671143003493 RNA binding site [nucleotide binding]; other site 671143003494 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 671143003495 RNA binding site [nucleotide binding]; other site 671143003496 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 671143003497 Dehydroquinase class II; Region: DHquinase_II; pfam01220 671143003498 active site 671143003499 trimer interface [polypeptide binding]; other site 671143003500 dimer interface [polypeptide binding]; other site 671143003501 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 671143003502 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 671143003503 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 671143003504 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 671143003505 Tetramer interface [polypeptide binding]; other site 671143003506 active site 671143003507 FMN-binding site [chemical binding]; other site 671143003508 AMIN domain; Region: AMIN; pfam11741 671143003509 Secretin and TonB N terminus short domain; Region: STN; pfam07660 671143003510 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 671143003511 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 671143003512 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 671143003513 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 671143003514 Pilus assembly protein, PilO; Region: PilO; cl01234 671143003515 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 671143003516 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 671143003517 Cell division protein FtsA; Region: FtsA; cl17206 671143003518 Competence protein A; Region: Competence_A; pfam11104 671143003519 Cell division protein FtsA; Region: FtsA; pfam14450 671143003520 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 671143003521 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 671143003522 substrate binding site [chemical binding]; other site 671143003523 active site 671143003524 catalytic residues [active] 671143003525 heterodimer interface [polypeptide binding]; other site 671143003526 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 671143003527 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 671143003528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143003529 catalytic residue [active] 671143003530 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 671143003531 active site 671143003532 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 671143003533 active site 671143003534 ribulose/triose binding site [chemical binding]; other site 671143003535 phosphate binding site [ion binding]; other site 671143003536 substrate (anthranilate) binding pocket [chemical binding]; other site 671143003537 product (indole) binding pocket [chemical binding]; other site 671143003538 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 671143003539 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 671143003540 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 671143003541 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2656657, 8939798; Product type e : enzyme 671143003542 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2656657, 8939798; Product type e : enzyme 671143003543 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 671143003544 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 671143003545 catalytic residues [active] 671143003546 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 671143003547 DNA binding residues [nucleotide binding] 671143003548 dimerization interface [polypeptide binding]; other site 671143003549 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 671143003550 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 671143003551 dimerization interface [polypeptide binding]; other site 671143003552 active site 671143003553 metal binding site [ion binding]; metal-binding site 671143003554 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 671143003555 dsRNA binding site [nucleotide binding]; other site 671143003556 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 671143003557 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 671143003558 Walker A/P-loop; other site 671143003559 ATP binding site [chemical binding]; other site 671143003560 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 671143003561 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 671143003562 Q-loop/lid; other site 671143003563 ABC transporter signature motif; other site 671143003564 Walker B; other site 671143003565 D-loop; other site 671143003566 H-loop/switch region; other site 671143003567 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 671143003568 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 671143003569 P loop; other site 671143003570 GTP binding site [chemical binding]; other site 671143003571 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 671143003572 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 671143003573 catalytic motif [active] 671143003574 Zn binding site [ion binding]; other site 671143003575 RibD C-terminal domain; Region: RibD_C; cl17279 671143003576 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 671143003577 Lumazine binding domain; Region: Lum_binding; pfam00677 671143003578 Lumazine binding domain; Region: Lum_binding; pfam00677 671143003579 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 671143003580 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 671143003581 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 671143003582 dimerization interface [polypeptide binding]; other site 671143003583 active site 671143003584 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 671143003585 homopentamer interface [polypeptide binding]; other site 671143003586 active site 671143003587 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 671143003588 putative RNA binding site [nucleotide binding]; other site 671143003589 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 671143003590 putative active site [active] 671143003591 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 671143003592 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 671143003593 dimer interface [polypeptide binding]; other site 671143003594 active site 671143003595 acyl carrier protein; Provisional; Region: acpP; PRK00982 671143003596 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 671143003597 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 671143003598 NAD(P) binding site [chemical binding]; other site 671143003599 homotetramer interface [polypeptide binding]; other site 671143003600 homodimer interface [polypeptide binding]; other site 671143003601 active site 671143003602 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 671143003603 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 671143003604 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 671143003605 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 671143003606 dimer interface [polypeptide binding]; other site 671143003607 active site 671143003608 CoA binding pocket [chemical binding]; other site 671143003609 putative phosphate acyltransferase; Provisional; Region: PRK05331 671143003610 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 671143003611 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 671143003612 active site 671143003613 multimer interface [polypeptide binding]; other site 671143003614 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 671143003615 CoA binding domain; Region: CoA_binding; smart00881 671143003616 CoA-ligase; Region: Ligase_CoA; pfam00549 671143003617 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 671143003618 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 671143003619 CoA-ligase; Region: Ligase_CoA; pfam00549 671143003620 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 671143003621 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 671143003622 ATP binding site [chemical binding]; other site 671143003623 putative Mg++ binding site [ion binding]; other site 671143003624 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 671143003625 nucleotide binding region [chemical binding]; other site 671143003626 ATP-binding site [chemical binding]; other site 671143003627 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 671143003628 RNase_H superfamily; Region: RNase_H_2; pfam13482 671143003629 active site 671143003630 substrate binding site [chemical binding]; other site 671143003631 catalytic site [active] 671143003632 Methyltransferase domain; Region: Methyltransf_31; pfam13847 671143003633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143003634 S-adenosylmethionine binding site [chemical binding]; other site 671143003635 Bifunctional nuclease; Region: DNase-RNase; pfam02577 671143003636 M28 Zn-Peptidases; Region: M28_like_1; cd05640 671143003637 Peptidase family M28; Region: Peptidase_M28; pfam04389 671143003638 metal binding site [ion binding]; metal-binding site 671143003639 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 671143003640 AsnC family; Region: AsnC_trans_reg; pfam01037 671143003641 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 671143003642 MG2 domain; Region: A2M_N; pfam01835 671143003643 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 671143003644 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 671143003645 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 671143003646 metal binding site [ion binding]; metal-binding site 671143003647 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 671143003648 Ligand binding site; other site 671143003649 Putative Catalytic site; other site 671143003650 DXD motif; other site 671143003651 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 671143003652 hypothetical protein; Provisional; Region: PRK02947 671143003653 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 671143003654 putative active site [active] 671143003655 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 671143003656 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 671143003657 active site 671143003658 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 671143003659 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 671143003660 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 671143003661 catalytic triad [active] 671143003662 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 671143003663 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 671143003664 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 671143003665 Methyltransferase domain; Region: Methyltransf_31; pfam13847 671143003666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143003667 S-adenosylmethionine binding site [chemical binding]; other site 671143003668 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 671143003669 Cytochrome c; Region: Cytochrom_C; pfam00034 671143003670 hypothetical protein; Reviewed; Region: PRK00024 671143003671 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 671143003672 MPN+ (JAMM) motif; other site 671143003673 Zinc-binding site [ion binding]; other site 671143003674 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 671143003675 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 671143003676 MgtE intracellular N domain; Region: MgtE_N; smart00924 671143003677 FOG: CBS domain [General function prediction only]; Region: COG0517 671143003678 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 671143003679 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 671143003680 PemK-like protein; Region: PemK; pfam02452 671143003681 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 671143003682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 671143003683 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 671143003684 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 671143003685 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 671143003686 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 671143003687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143003688 sequence-specific DNA binding site [nucleotide binding]; other site 671143003689 salt bridge; other site 671143003690 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 671143003691 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 671143003692 metal binding triad [ion binding]; metal-binding site 671143003693 Protein of unknown function (DUF497); Region: DUF497; pfam04365 671143003694 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 671143003695 MgtE intracellular N domain; Region: MgtE_N; smart00924 671143003696 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 671143003697 Divalent cation transporter; Region: MgtE; pfam01769 671143003698 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 671143003699 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 671143003700 amidophosphoribosyltransferase; Provisional; Region: PRK09123 671143003701 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 671143003702 active site 671143003703 tetramer interface [polypeptide binding]; other site 671143003704 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 671143003705 active site 671143003706 aminotransferase; Validated; Region: PRK08175 671143003707 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 671143003708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143003709 homodimer interface [polypeptide binding]; other site 671143003710 catalytic residue [active] 671143003711 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 671143003712 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 671143003713 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 671143003714 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 671143003715 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 671143003716 active site 671143003717 HIGH motif; other site 671143003718 KMSK motif region; other site 671143003719 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 671143003720 tRNA binding surface [nucleotide binding]; other site 671143003721 anticodon binding site; other site 671143003722 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 671143003723 active site residue [active] 671143003724 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 671143003725 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 671143003726 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 671143003727 active site lid residues [active] 671143003728 substrate binding pocket [chemical binding]; other site 671143003729 catalytic residues [active] 671143003730 substrate-Mg2+ binding site; other site 671143003731 aspartate-rich region 1; other site 671143003732 aspartate-rich region 2; other site 671143003733 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 671143003734 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 671143003735 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 671143003736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 671143003737 Coenzyme A binding pocket [chemical binding]; other site 671143003738 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 671143003739 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 671143003740 putative active site [active] 671143003741 adenylation catalytic residue [active] 671143003742 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 671143003743 active site 2 [active] 671143003744 active site 1 [active] 671143003745 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 671143003746 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 671143003747 TrkA-N domain; Region: TrkA_N; pfam02254 671143003748 TrkA-C domain; Region: TrkA_C; pfam02080 671143003749 TrkA-N domain; Region: TrkA_N; pfam02254 671143003750 TrkA-C domain; Region: TrkA_C; pfam02080 671143003751 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 671143003752 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 671143003753 TAP-like protein; Region: Abhydrolase_4; pfam08386 671143003754 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 671143003755 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 671143003756 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 671143003757 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 671143003758 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 671143003759 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 671143003760 NAD(P) binding site [chemical binding]; other site 671143003761 catalytic residues [active] 671143003762 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 671143003763 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 671143003764 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 671143003765 Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965 671143003766 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 671143003767 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 671143003768 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 671143003769 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 671143003770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 671143003771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143003772 active site 671143003773 phosphorylation site [posttranslational modification] 671143003774 intermolecular recognition site; other site 671143003775 dimerization interface [polypeptide binding]; other site 671143003776 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 671143003777 DNA binding residues [nucleotide binding] 671143003778 dimerization interface [polypeptide binding]; other site 671143003779 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 671143003780 PAS domain; Region: PAS; smart00091 671143003781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143003782 ATP binding site [chemical binding]; other site 671143003783 Mg2+ binding site [ion binding]; other site 671143003784 G-X-G motif; other site 671143003785 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 671143003786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 671143003787 Walker A/P-loop; other site 671143003788 ATP binding site [chemical binding]; other site 671143003789 Q-loop/lid; other site 671143003790 ABC transporter signature motif; other site 671143003791 Walker B; other site 671143003792 D-loop; other site 671143003793 H-loop/switch region; other site 671143003794 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 671143003795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 671143003796 dimer interface [polypeptide binding]; other site 671143003797 conserved gate region; other site 671143003798 ABC-ATPase subunit interface; other site 671143003799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 671143003800 dimer interface [polypeptide binding]; other site 671143003801 conserved gate region; other site 671143003802 putative PBP binding loops; other site 671143003803 ABC-ATPase subunit interface; other site 671143003804 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 671143003805 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 671143003806 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 671143003807 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 671143003808 active site 671143003809 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 671143003810 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 671143003811 active site 671143003812 motif I; other site 671143003813 motif II; other site 671143003814 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 671143003815 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 671143003816 Response regulator receiver domain; Region: Response_reg; pfam00072 671143003817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143003818 active site 671143003819 phosphorylation site [posttranslational modification] 671143003820 intermolecular recognition site; other site 671143003821 dimerization interface [polypeptide binding]; other site 671143003822 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 671143003823 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 671143003824 MOFRL family; Region: MOFRL; pfam05161 671143003825 sensor protein ZraS; Provisional; Region: PRK10364 671143003826 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 671143003827 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143003828 dimerization interface [polypeptide binding]; other site 671143003829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143003830 phosphorylation site [posttranslational modification] 671143003831 dimer interface [polypeptide binding]; other site 671143003832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143003833 ATP binding site [chemical binding]; other site 671143003834 G-X-G motif; other site 671143003835 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 671143003836 Cytochrome c; Region: Cytochrom_C; pfam00034 671143003837 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 671143003838 active site 671143003839 substrate binding site [chemical binding]; other site 671143003840 metal binding site [ion binding]; metal-binding site 671143003841 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 671143003842 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 671143003843 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 671143003844 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 671143003845 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 671143003846 HIGH motif; other site 671143003847 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 671143003848 active site 671143003849 KMSKS motif; other site 671143003850 Uncharacterized conserved protein [Function unknown]; Region: COG2835 671143003851 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 671143003852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 671143003853 Coenzyme A binding pocket [chemical binding]; other site 671143003854 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 671143003855 Glycoprotease family; Region: Peptidase_M22; pfam00814 671143003856 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 671143003857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 671143003858 putative substrate translocation pore; other site 671143003859 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 671143003860 putative carbohydrate kinase; Provisional; Region: PRK10565 671143003861 Uncharacterized conserved protein [Function unknown]; Region: COG0062 671143003862 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 671143003863 putative substrate binding site [chemical binding]; other site 671143003864 putative ATP binding site [chemical binding]; other site 671143003865 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 671143003866 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 671143003867 active site 671143003868 hydrophilic channel; other site 671143003869 dimerization interface [polypeptide binding]; other site 671143003870 catalytic residues [active] 671143003871 active site lid [active] 671143003872 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 671143003873 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 671143003874 active site 671143003875 substrate binding site [chemical binding]; other site 671143003876 metal binding site [ion binding]; metal-binding site 671143003877 YbbR-like protein; Region: YbbR; pfam07949 671143003878 Uncharacterized conserved protein [Function unknown]; Region: COG1624 671143003879 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 671143003880 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 671143003881 dihydropteroate synthase; Region: DHPS; TIGR01496 671143003882 substrate binding pocket [chemical binding]; other site 671143003883 dimer interface [polypeptide binding]; other site 671143003884 inhibitor binding site; inhibition site 671143003885 FtsH Extracellular; Region: FtsH_ext; pfam06480 671143003886 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 671143003887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143003888 Walker A motif; other site 671143003889 ATP binding site [chemical binding]; other site 671143003890 Walker B motif; other site 671143003891 arginine finger; other site 671143003892 Peptidase family M41; Region: Peptidase_M41; pfam01434 671143003893 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 671143003894 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 671143003895 Ligand Binding Site [chemical binding]; other site 671143003896 TilS substrate C-terminal domain; Region: TilS_C; smart00977 671143003897 FecR protein; Region: FecR; pfam04773 671143003898 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 671143003899 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 671143003900 active site 671143003901 metal binding site [ion binding]; metal-binding site 671143003902 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 671143003903 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 671143003904 active site 671143003905 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 671143003906 ThiC family; Region: ThiC; pfam01964 671143003907 RmuC family; Region: RmuC; pfam02646 671143003908 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 671143003909 hypothetical protein; Reviewed; Region: PRK09588 671143003910 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 671143003911 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143003912 FeS/SAM binding site; other site 671143003913 Protein of unknown function (DUF433); Region: DUF433; pfam04255 671143003914 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 671143003915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143003916 non-specific DNA binding site [nucleotide binding]; other site 671143003917 salt bridge; other site 671143003918 sequence-specific DNA binding site [nucleotide binding]; other site 671143003919 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 671143003920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143003921 FeS/SAM binding site; other site 671143003922 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 671143003923 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 671143003924 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 671143003925 catalytic residues [active] 671143003926 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 671143003927 CcmE; Region: CcmE; pfam03100 671143003928 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 671143003929 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 671143003930 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 671143003931 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 671143003932 Walker A/P-loop; other site 671143003933 ATP binding site [chemical binding]; other site 671143003934 Q-loop/lid; other site 671143003935 ABC transporter signature motif; other site 671143003936 Walker B; other site 671143003937 D-loop; other site 671143003938 H-loop/switch region; other site 671143003939 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 671143003940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143003941 active site 671143003942 phosphorylation site [posttranslational modification] 671143003943 intermolecular recognition site; other site 671143003944 dimerization interface [polypeptide binding]; other site 671143003945 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 671143003946 Zn2+ binding site [ion binding]; other site 671143003947 Mg2+ binding site [ion binding]; other site 671143003948 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 671143003949 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 671143003950 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 671143003951 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 671143003952 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 671143003953 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 671143003954 E3 interaction surface; other site 671143003955 lipoyl attachment site [posttranslational modification]; other site 671143003956 e3 binding domain; Region: E3_binding; pfam02817 671143003957 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 671143003958 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 671143003959 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 671143003960 alpha subunit interface [polypeptide binding]; other site 671143003961 TPP binding site [chemical binding]; other site 671143003962 heterodimer interface [polypeptide binding]; other site 671143003963 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 671143003964 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 671143003965 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 671143003966 tetramer interface [polypeptide binding]; other site 671143003967 TPP-binding site [chemical binding]; other site 671143003968 heterodimer interface [polypeptide binding]; other site 671143003969 phosphorylation loop region [posttranslational modification] 671143003970 lipoyl synthase; Provisional; Region: PRK05481 671143003971 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143003972 FeS/SAM binding site; other site 671143003973 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 671143003974 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 671143003975 active site 671143003976 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 671143003977 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 671143003978 VIT family; Region: VIT1; pfam01988 671143003979 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 671143003980 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 671143003981 4Fe-4S binding domain; Region: Fer4; pfam00037 671143003982 4Fe-4S binding domain; Region: Fer4; pfam00037 671143003983 NADH dehydrogenase subunit B; Validated; Region: PRK06411 671143003984 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 671143003985 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 671143003986 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 671143003987 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 671143003988 catalytic residue [active] 671143003989 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 671143003990 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 671143003991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143003992 FeS/SAM binding site; other site 671143003993 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 671143003994 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 671143003995 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 671143003996 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 671143003997 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 671143003998 dimer interface [polypeptide binding]; other site 671143003999 putative functional site; other site 671143004000 putative MPT binding site; other site 671143004001 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 671143004002 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 671143004003 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 671143004004 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 671143004005 4Fe-4S binding domain; Region: Fer4; pfam00037 671143004006 NADH dehydrogenase subunit B; Validated; Region: PRK06411 671143004007 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 671143004008 catalytic loop [active] 671143004009 iron binding site [ion binding]; other site 671143004010 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 671143004011 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 671143004012 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 671143004013 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 671143004014 FOG: CBS domain [General function prediction only]; Region: COG0517 671143004015 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 671143004016 FOG: CBS domain [General function prediction only]; Region: COG0517 671143004017 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 671143004018 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 671143004019 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 671143004020 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 671143004021 dimer interface [polypeptide binding]; other site 671143004022 PYR/PP interface [polypeptide binding]; other site 671143004023 TPP binding site [chemical binding]; other site 671143004024 substrate binding site [chemical binding]; other site 671143004025 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 671143004026 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 671143004027 TPP-binding site [chemical binding]; other site 671143004028 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 671143004029 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 671143004030 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 671143004031 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 671143004032 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 671143004033 CARDB; Region: CARDB; pfam07705 671143004034 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 671143004035 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 671143004036 active site 671143004037 substrate binding site [chemical binding]; other site 671143004038 cosubstrate binding site; other site 671143004039 catalytic site [active] 671143004040 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 671143004041 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 671143004042 purine monophosphate binding site [chemical binding]; other site 671143004043 dimer interface [polypeptide binding]; other site 671143004044 putative catalytic residues [active] 671143004045 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 671143004046 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 671143004047 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 671143004048 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 671143004049 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 671143004050 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 671143004051 AIR carboxylase; Region: AIRC; pfam00731 671143004052 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 671143004053 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 671143004054 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 671143004055 Ligand binding site; other site 671143004056 Putative Catalytic site; other site 671143004057 DXD motif; other site 671143004058 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 671143004059 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 671143004060 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 671143004061 active site 671143004062 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 671143004063 dimerization interface [polypeptide binding]; other site 671143004064 putative ATP binding site [chemical binding]; other site 671143004065 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143004066 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143004067 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143004068 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 671143004069 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 671143004070 putative ligand binding pocket/active site [active] 671143004071 putative metal binding site [ion binding]; other site 671143004072 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 671143004073 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 671143004074 putative active site [active] 671143004075 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 671143004076 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 671143004077 putative active site [active] 671143004078 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 671143004079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 671143004080 active site 671143004081 motif I; other site 671143004082 motif II; other site 671143004083 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 671143004084 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 671143004085 putative acyl-acceptor binding pocket; other site 671143004086 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 671143004087 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 671143004088 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 671143004089 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 671143004090 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 671143004091 putative acyl-acceptor binding pocket; other site 671143004092 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 671143004093 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 671143004094 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 671143004095 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 671143004096 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 671143004097 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 671143004098 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 671143004099 active site 671143004100 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 671143004101 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 671143004102 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 671143004103 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 671143004104 trimer interface [polypeptide binding]; other site 671143004105 active site 671143004106 UDP-GlcNAc binding site [chemical binding]; other site 671143004107 lipid binding site [chemical binding]; lipid-binding site 671143004108 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 671143004109 periplasmic chaperone; Provisional; Region: PRK10780 671143004110 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 671143004111 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 671143004112 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 671143004113 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 671143004114 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 671143004115 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 671143004116 Surface antigen; Region: Bac_surface_Ag; pfam01103 671143004117 Clp protease ATP binding subunit; Region: clpC; CHL00095 671143004118 Clp amino terminal domain; Region: Clp_N; pfam02861 671143004119 Clp amino terminal domain; Region: Clp_N; pfam02861 671143004120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143004121 Walker A motif; other site 671143004122 ATP binding site [chemical binding]; other site 671143004123 Walker B motif; other site 671143004124 arginine finger; other site 671143004125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143004126 Walker A motif; other site 671143004127 ATP binding site [chemical binding]; other site 671143004128 Walker B motif; other site 671143004129 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 671143004130 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 671143004131 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 671143004132 Walker A/P-loop; other site 671143004133 ATP binding site [chemical binding]; other site 671143004134 Q-loop/lid; other site 671143004135 ABC transporter signature motif; other site 671143004136 Walker B; other site 671143004137 D-loop; other site 671143004138 H-loop/switch region; other site 671143004139 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 671143004140 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 671143004141 FtsX-like permease family; Region: FtsX; pfam02687 671143004142 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 671143004143 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 671143004144 dimer interface [polypeptide binding]; other site 671143004145 putative anticodon binding site; other site 671143004146 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 671143004147 motif 1; other site 671143004148 active site 671143004149 motif 2; other site 671143004150 motif 3; other site 671143004151 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 671143004152 UbiA prenyltransferase family; Region: UbiA; pfam01040 671143004153 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 671143004154 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 671143004155 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 671143004156 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 671143004157 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 671143004158 active site 671143004159 metal binding site [ion binding]; metal-binding site 671143004160 Cytochrome c [Energy production and conversion]; Region: COG3258 671143004161 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 671143004162 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 671143004163 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 671143004164 pyruvate phosphate dikinase; Provisional; Region: PRK09279 671143004165 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 671143004166 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 671143004167 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 671143004168 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 671143004169 Cytochrome c; Region: Cytochrom_C; pfam00034 671143004170 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 671143004171 Cytochrome c; Region: Cytochrom_C; cl11414 671143004172 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 671143004173 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 671143004174 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 671143004175 heme bH binding site [chemical binding]; other site 671143004176 intrachain domain interface; other site 671143004177 Qi binding site; other site 671143004178 heme bL binding site [chemical binding]; other site 671143004179 interchain domain interface [polypeptide binding]; other site 671143004180 Qo binding site; other site 671143004181 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 671143004182 iron-sulfur cluster [ion binding]; other site 671143004183 [2Fe-2S] cluster binding site [ion binding]; other site 671143004184 putative transposase OrfB; Reviewed; Region: PHA02517 671143004185 HTH-like domain; Region: HTH_21; pfam13276 671143004186 Integrase core domain; Region: rve; pfam00665 671143004187 Integrase core domain; Region: rve_3; pfam13683 671143004188 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 671143004189 DNA binding site [nucleotide binding] 671143004190 active site 671143004191 Int/Topo IB signature motif; other site 671143004192 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 671143004193 minor groove reading motif; other site 671143004194 helix-hairpin-helix signature motif; other site 671143004195 active site 671143004196 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 671143004197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143004198 non-specific DNA binding site [nucleotide binding]; other site 671143004199 salt bridge; other site 671143004200 sequence-specific DNA binding site [nucleotide binding]; other site 671143004201 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 671143004202 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 671143004203 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 671143004204 Ligand Binding Site [chemical binding]; other site 671143004205 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 671143004206 Hemerythrin-like domain; Region: Hr-like; cd12108 671143004207 Fe binding site [ion binding]; other site 671143004208 antiporter inner membrane protein; Provisional; Region: PRK11670 671143004209 Domain of unknown function DUF59; Region: DUF59; pfam01883 671143004210 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 671143004211 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 671143004212 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 671143004213 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 671143004214 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 671143004215 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 671143004216 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 671143004217 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 671143004218 ligand binding site [chemical binding]; other site 671143004219 flexible hinge region; other site 671143004220 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 671143004221 putative switch regulator; other site 671143004222 non-specific DNA interactions [nucleotide binding]; other site 671143004223 DNA binding site [nucleotide binding] 671143004224 sequence specific DNA binding site [nucleotide binding]; other site 671143004225 putative cAMP binding site [chemical binding]; other site 671143004226 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 671143004227 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 671143004228 catalytic residues [active] 671143004229 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 671143004230 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 671143004231 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 671143004232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004233 active site 671143004234 phosphorylation site [posttranslational modification] 671143004235 intermolecular recognition site; other site 671143004236 ANTAR domain; Region: ANTAR; pfam03861 671143004237 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 671143004238 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 671143004239 Staphylococcal nuclease homologues; Region: SNc; smart00318 671143004240 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 671143004241 Catalytic site; other site 671143004242 Lamin Tail Domain; Region: LTD; pfam00932 671143004243 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 671143004244 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 671143004245 putative active site [active] 671143004246 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 671143004247 active site 671143004248 NTP binding site [chemical binding]; other site 671143004249 metal binding triad [ion binding]; metal-binding site 671143004250 antibiotic binding site [chemical binding]; other site 671143004251 HEPN domain; Region: HEPN; pfam05168 671143004252 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 671143004253 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 671143004254 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 671143004255 putative active site [active] 671143004256 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 671143004257 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 671143004258 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 671143004259 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 671143004260 ANTAR domain; Region: ANTAR; pfam03861 671143004261 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 671143004262 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 671143004263 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143004264 dimerization interface [polypeptide binding]; other site 671143004265 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 671143004266 dimer interface [polypeptide binding]; other site 671143004267 putative CheW interface [polypeptide binding]; other site 671143004268 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143004269 dimerization interface [polypeptide binding]; other site 671143004270 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 671143004271 GAF domain; Region: GAF; pfam01590 671143004272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143004273 dimer interface [polypeptide binding]; other site 671143004274 phosphorylation site [posttranslational modification] 671143004275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143004276 ATP binding site [chemical binding]; other site 671143004277 Mg2+ binding site [ion binding]; other site 671143004278 G-X-G motif; other site 671143004279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004280 Response regulator receiver domain; Region: Response_reg; pfam00072 671143004281 active site 671143004282 phosphorylation site [posttranslational modification] 671143004283 intermolecular recognition site; other site 671143004284 dimerization interface [polypeptide binding]; other site 671143004285 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 671143004286 GAF domain; Region: GAF; pfam01590 671143004287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 671143004288 dimer interface [polypeptide binding]; other site 671143004289 phosphorylation site [posttranslational modification] 671143004290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143004291 dimerization interface [polypeptide binding]; other site 671143004292 histidine kinase; Provisional; Region: PRK13557 671143004293 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143004294 putative active site [active] 671143004295 heme pocket [chemical binding]; other site 671143004296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143004297 ATP binding site [chemical binding]; other site 671143004298 Mg2+ binding site [ion binding]; other site 671143004299 G-X-G motif; other site 671143004300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004301 active site 671143004302 phosphorylation site [posttranslational modification] 671143004303 intermolecular recognition site; other site 671143004304 dimerization interface [polypeptide binding]; other site 671143004305 ANTAR domain; Region: ANTAR; pfam03861 671143004306 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 671143004307 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 671143004308 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 671143004309 GAF domain; Region: GAF; pfam01590 671143004310 ANTAR domain; Region: ANTAR; pfam03861 671143004311 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 671143004312 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143004313 dimerization interface [polypeptide binding]; other site 671143004314 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 671143004315 dimer interface [polypeptide binding]; other site 671143004316 putative CheW interface [polypeptide binding]; other site 671143004317 Nitrate and nitrite sensing; Region: NIT; pfam08376 671143004318 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143004319 dimerization interface [polypeptide binding]; other site 671143004320 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 671143004321 dimer interface [polypeptide binding]; other site 671143004322 putative CheW interface [polypeptide binding]; other site 671143004323 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 671143004324 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 671143004325 dimer interface [polypeptide binding]; other site 671143004326 ssDNA binding site [nucleotide binding]; other site 671143004327 tetramer (dimer of dimers) interface [polypeptide binding]; other site 671143004328 PilZ domain; Region: PilZ; pfam07238 671143004329 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 671143004330 Peptidase family M23; Region: Peptidase_M23; pfam01551 671143004331 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 671143004332 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 671143004333 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 671143004334 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 671143004335 DNA binding residues [nucleotide binding] 671143004336 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 671143004337 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 671143004338 P-loop; other site 671143004339 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 671143004340 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 671143004341 GTP/Mg2+ binding site [chemical binding]; other site 671143004342 G5 box; other site 671143004343 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 671143004344 G1 box; other site 671143004345 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 671143004346 FHIPEP family; Region: FHIPEP; pfam00771 671143004347 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 671143004348 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 671143004349 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 671143004350 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 671143004351 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 671143004352 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 671143004353 flagellar motor switch protein; Validated; Region: PRK08119 671143004354 flagellar motor switch protein FliN; Region: fliN; TIGR02480 671143004355 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 671143004356 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 671143004357 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 671143004358 Flagellar protein (FlbD); Region: FlbD; pfam06289 671143004359 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 671143004360 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 671143004361 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 671143004362 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 671143004363 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 671143004364 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 671143004365 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 671143004366 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 671143004367 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 671143004368 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 671143004369 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 671143004370 Uncharacterized conserved protein [Function unknown]; Region: COG3334 671143004371 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 671143004372 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 671143004373 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 671143004374 Walker A motif/ATP binding site; other site 671143004375 Walker B motif; other site 671143004376 Flagellar assembly protein FliH; Region: FliH; pfam02108 671143004377 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 671143004378 FliG C-terminal domain; Region: FliG_C; pfam01706 671143004379 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 671143004380 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 671143004381 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 671143004382 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 671143004383 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 671143004384 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 671143004385 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 671143004386 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143004387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004388 active site 671143004389 phosphorylation site [posttranslational modification] 671143004390 intermolecular recognition site; other site 671143004391 dimerization interface [polypeptide binding]; other site 671143004392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143004393 Walker A motif; other site 671143004394 ATP binding site [chemical binding]; other site 671143004395 Walker B motif; other site 671143004396 arginine finger; other site 671143004397 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143004398 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 671143004399 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143004400 putative active site [active] 671143004401 heme pocket [chemical binding]; other site 671143004402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143004403 dimer interface [polypeptide binding]; other site 671143004404 phosphorylation site [posttranslational modification] 671143004405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143004406 ATP binding site [chemical binding]; other site 671143004407 Mg2+ binding site [ion binding]; other site 671143004408 G-X-G motif; other site 671143004409 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 671143004410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004411 active site 671143004412 phosphorylation site [posttranslational modification] 671143004413 intermolecular recognition site; other site 671143004414 dimerization interface [polypeptide binding]; other site 671143004415 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 671143004416 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 671143004417 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 671143004418 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 671143004419 ligand binding site [chemical binding]; other site 671143004420 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143004421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004422 active site 671143004423 phosphorylation site [posttranslational modification] 671143004424 intermolecular recognition site; other site 671143004425 dimerization interface [polypeptide binding]; other site 671143004426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143004427 Walker A motif; other site 671143004428 ATP binding site [chemical binding]; other site 671143004429 Walker B motif; other site 671143004430 arginine finger; other site 671143004431 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143004432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143004433 dimer interface [polypeptide binding]; other site 671143004434 phosphorylation site [posttranslational modification] 671143004435 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 671143004436 Response regulator receiver domain; Region: Response_reg; pfam00072 671143004437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004438 active site 671143004439 phosphorylation site [posttranslational modification] 671143004440 intermolecular recognition site; other site 671143004441 dimerization interface [polypeptide binding]; other site 671143004442 GAF domain; Region: GAF_2; pfam13185 671143004443 GAF domain; Region: GAF_3; pfam13492 671143004444 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 671143004445 Zn2+ binding site [ion binding]; other site 671143004446 Mg2+ binding site [ion binding]; other site 671143004447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004448 active site 671143004449 phosphorylation site [posttranslational modification] 671143004450 intermolecular recognition site; other site 671143004451 dimerization interface [polypeptide binding]; other site 671143004452 FlaG protein; Region: FlaG; pfam03646 671143004453 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 671143004454 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 671143004455 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 671143004456 Flagellar protein FliS; Region: FliS; cl00654 671143004457 flagellin; Provisional; Region: PRK12802 671143004458 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 671143004459 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 671143004460 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 671143004461 putative metal binding site; other site 671143004462 TPR repeat; Region: TPR_11; pfam13414 671143004463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143004464 binding surface 671143004465 TPR motif; other site 671143004466 TPR repeat; Region: TPR_11; pfam13414 671143004467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143004468 TPR motif; other site 671143004469 binding surface 671143004470 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 671143004471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004472 active site 671143004473 phosphorylation site [posttranslational modification] 671143004474 intermolecular recognition site; other site 671143004475 dimerization interface [polypeptide binding]; other site 671143004476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004477 Response regulator receiver domain; Region: Response_reg; pfam00072 671143004478 active site 671143004479 phosphorylation site [posttranslational modification] 671143004480 intermolecular recognition site; other site 671143004481 dimerization interface [polypeptide binding]; other site 671143004482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143004483 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143004484 putative active site [active] 671143004485 heme pocket [chemical binding]; other site 671143004486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143004487 dimer interface [polypeptide binding]; other site 671143004488 phosphorylation site [posttranslational modification] 671143004489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143004490 ATP binding site [chemical binding]; other site 671143004491 Mg2+ binding site [ion binding]; other site 671143004492 G-X-G motif; other site 671143004493 Response regulator receiver domain; Region: Response_reg; pfam00072 671143004494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004495 active site 671143004496 phosphorylation site [posttranslational modification] 671143004497 intermolecular recognition site; other site 671143004498 dimerization interface [polypeptide binding]; other site 671143004499 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143004500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143004501 dimer interface [polypeptide binding]; other site 671143004502 phosphorylation site [posttranslational modification] 671143004503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143004504 ATP binding site [chemical binding]; other site 671143004505 Mg2+ binding site [ion binding]; other site 671143004506 G-X-G motif; other site 671143004507 Response regulator receiver domain; Region: Response_reg; pfam00072 671143004508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004509 active site 671143004510 phosphorylation site [posttranslational modification] 671143004511 intermolecular recognition site; other site 671143004512 dimerization interface [polypeptide binding]; other site 671143004513 Hpt domain; Region: Hpt; pfam01627 671143004514 putative binding surface; other site 671143004515 active site 671143004516 HDOD domain; Region: HDOD; pfam08668 671143004517 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 671143004518 Zn2+ binding site [ion binding]; other site 671143004519 Mg2+ binding site [ion binding]; other site 671143004520 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 671143004521 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 671143004522 putative metal binding site; other site 671143004523 Tetratricopeptide repeat; Region: TPR_12; pfam13424 671143004524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143004525 binding surface 671143004526 TPR motif; other site 671143004527 TPR repeat; Region: TPR_11; pfam13414 671143004528 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 671143004529 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143004530 binding surface 671143004531 TPR motif; other site 671143004532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143004533 binding surface 671143004534 TPR motif; other site 671143004535 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 671143004536 Methyltransferase domain; Region: Methyltransf_31; pfam13847 671143004537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143004538 S-adenosylmethionine binding site [chemical binding]; other site 671143004539 TPR repeat; Region: TPR_11; pfam13414 671143004540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143004541 TPR motif; other site 671143004542 binding surface 671143004543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143004544 binding surface 671143004545 Tetratricopeptide repeat; Region: TPR_16; pfam13432 671143004546 TPR motif; other site 671143004547 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 671143004548 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 671143004549 Probable Catalytic site; other site 671143004550 metal-binding site 671143004551 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 671143004552 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 671143004553 TPR repeat; Region: TPR_11; pfam13414 671143004554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143004555 TPR motif; other site 671143004556 binding surface 671143004557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143004558 binding surface 671143004559 Tetratricopeptide repeat; Region: TPR_16; pfam13432 671143004560 TPR motif; other site 671143004561 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 671143004562 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 671143004563 Probable Catalytic site; other site 671143004564 metal-binding site 671143004565 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 671143004566 Probable Catalytic site; other site 671143004567 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 671143004568 metal-binding site 671143004569 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 671143004570 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 671143004571 Probable Catalytic site; other site 671143004572 metal-binding site 671143004573 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 671143004574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143004575 S-adenosylmethionine binding site [chemical binding]; other site 671143004576 pseudaminic acid synthase; Region: PseI; TIGR03586 671143004577 NeuB family; Region: NeuB; pfam03102 671143004578 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 671143004579 NeuB binding interface [polypeptide binding]; other site 671143004580 putative substrate binding site [chemical binding]; other site 671143004581 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 671143004582 active site 671143004583 cosubstrate binding site; other site 671143004584 substrate binding site [chemical binding]; other site 671143004585 catalytic site [active] 671143004586 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 671143004587 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 671143004588 ligand binding site; other site 671143004589 tetramer interface; other site 671143004590 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 671143004591 phosphate binding site [ion binding]; other site 671143004592 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 671143004593 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 671143004594 inhibitor-cofactor binding pocket; inhibition site 671143004595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143004596 catalytic residue [active] 671143004597 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 671143004598 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 671143004599 NAD(P) binding site [chemical binding]; other site 671143004600 homodimer interface [polypeptide binding]; other site 671143004601 substrate binding site [chemical binding]; other site 671143004602 active site 671143004603 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 671143004604 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 671143004605 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 671143004606 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 671143004607 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 671143004608 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 671143004609 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 671143004610 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 671143004611 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 671143004612 putative active site [active] 671143004613 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 671143004614 putative active site [active] 671143004615 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 671143004616 putative active site [active] 671143004617 Global regulator protein family; Region: CsrA; pfam02599 671143004618 FliW protein; Region: FliW; cl00740 671143004619 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 671143004620 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 671143004621 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 671143004622 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 671143004623 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 671143004624 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 671143004625 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 671143004626 FlgN protein; Region: FlgN; pfam05130 671143004627 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 671143004628 Rod binding protein; Region: Rod-binding; pfam10135 671143004629 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 671143004630 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 671143004631 Flagellar L-ring protein; Region: FlgH; pfam02107 671143004632 SAF-like; Region: SAF_2; pfam13144 671143004633 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 671143004634 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 671143004635 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 671143004636 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 671143004637 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 671143004638 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 671143004639 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 671143004640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 671143004641 active site 671143004642 phosphorylation site [posttranslational modification] 671143004643 intermolecular recognition site; other site 671143004644 dimerization interface [polypeptide binding]; other site 671143004645 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 671143004646 metal binding site [ion binding]; metal-binding site 671143004647 active site 671143004648 I-site; other site 671143004649 HDOD domain; Region: HDOD; pfam08668 671143004650 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 671143004651 Zn2+ binding site [ion binding]; other site 671143004652 Mg2+ binding site [ion binding]; other site 671143004653 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 671143004654 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143004655 dimerization interface [polypeptide binding]; other site 671143004656 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 671143004657 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 671143004658 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 671143004659 ligand binding site [chemical binding]; other site 671143004660 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 671143004661 flagellar motor protein MotA; Validated; Region: PRK08124 671143004662 Response regulator receiver domain; Region: Response_reg; pfam00072 671143004663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004664 active site 671143004665 phosphorylation site [posttranslational modification] 671143004666 intermolecular recognition site; other site 671143004667 dimerization interface [polypeptide binding]; other site 671143004668 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 671143004669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004670 active site 671143004671 phosphorylation site [posttranslational modification] 671143004672 intermolecular recognition site; other site 671143004673 dimerization interface [polypeptide binding]; other site 671143004674 CheB methylesterase; Region: CheB_methylest; pfam01339 671143004675 CheD chemotactic sensory transduction; Region: CheD; cl00810 671143004676 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 671143004677 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 671143004678 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 671143004679 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 671143004680 putative CheA interaction surface; other site 671143004681 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 671143004682 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143004683 dimerization interface [polypeptide binding]; other site 671143004684 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 671143004685 dimer interface [polypeptide binding]; other site 671143004686 putative CheW interface [polypeptide binding]; other site 671143004687 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 671143004688 chemotaxis protein CheA; Provisional; Region: PRK10547 671143004689 putative binding surface; other site 671143004690 active site 671143004691 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 671143004692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143004693 ATP binding site [chemical binding]; other site 671143004694 Mg2+ binding site [ion binding]; other site 671143004695 G-X-G motif; other site 671143004696 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 671143004697 Response regulator receiver domain; Region: Response_reg; pfam00072 671143004698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004699 active site 671143004700 phosphorylation site [posttranslational modification] 671143004701 intermolecular recognition site; other site 671143004702 dimerization interface [polypeptide binding]; other site 671143004703 sensory histidine kinase AtoS; Provisional; Region: PRK11360 671143004704 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 671143004705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143004706 dimerization interface [polypeptide binding]; other site 671143004707 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143004708 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 671143004709 putative active site [active] 671143004710 heme pocket [chemical binding]; other site 671143004711 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 671143004712 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143004713 dimer interface [polypeptide binding]; other site 671143004714 phosphorylation site [posttranslational modification] 671143004715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143004716 ATP binding site [chemical binding]; other site 671143004717 Mg2+ binding site [ion binding]; other site 671143004718 G-X-G motif; other site 671143004719 Response regulator receiver domain; Region: Response_reg; pfam00072 671143004720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004721 active site 671143004722 phosphorylation site [posttranslational modification] 671143004723 intermolecular recognition site; other site 671143004724 dimerization interface [polypeptide binding]; other site 671143004725 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 671143004726 active site 671143004727 dimerization interface [polypeptide binding]; other site 671143004728 ribonuclease PH; Reviewed; Region: rph; PRK00173 671143004729 Ribonuclease PH; Region: RNase_PH_bact; cd11362 671143004730 hexamer interface [polypeptide binding]; other site 671143004731 active site 671143004732 Sporulation and spore germination; Region: Germane; pfam10646 671143004733 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 671143004734 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 671143004735 active site 671143004736 metal binding site [ion binding]; metal-binding site 671143004737 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 671143004738 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 671143004739 active site 671143004740 HIGH motif; other site 671143004741 dimer interface [polypeptide binding]; other site 671143004742 KMSKS motif; other site 671143004743 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 671143004744 RNA binding surface [nucleotide binding]; other site 671143004745 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 671143004746 Transglycosylase; Region: Transgly; pfam00912 671143004747 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 671143004748 RNA binding site [nucleotide binding]; other site 671143004749 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 671143004750 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 671143004751 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 671143004752 NAD(P) binding site [chemical binding]; other site 671143004753 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 671143004754 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 671143004755 NAD(P) binding site [chemical binding]; other site 671143004756 Protein of unknown function (DUF971); Region: DUF971; pfam06155 671143004757 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 671143004758 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 671143004759 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 671143004760 homodimer interface [polypeptide binding]; other site 671143004761 NADP binding site [chemical binding]; other site 671143004762 substrate binding site [chemical binding]; other site 671143004763 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 671143004764 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 671143004765 putative active site [active] 671143004766 metal binding site [ion binding]; metal-binding site 671143004767 homodimer binding site [polypeptide binding]; other site 671143004768 phosphodiesterase; Provisional; Region: PRK12704 671143004769 V-type ATP synthase subunit E; Provisional; Region: PRK01558 671143004770 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 671143004771 Zn2+ binding site [ion binding]; other site 671143004772 Mg2+ binding site [ion binding]; other site 671143004773 Cell division protein ZapA; Region: ZapA; pfam05164 671143004774 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 671143004775 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 671143004776 putative tRNA-binding site [nucleotide binding]; other site 671143004777 B3/4 domain; Region: B3_4; pfam03483 671143004778 tRNA synthetase B5 domain; Region: B5; smart00874 671143004779 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 671143004780 dimer interface [polypeptide binding]; other site 671143004781 motif 1; other site 671143004782 motif 3; other site 671143004783 motif 2; other site 671143004784 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 671143004785 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 671143004786 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 671143004787 putative active site [active] 671143004788 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 671143004789 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 671143004790 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 671143004791 dimer interface [polypeptide binding]; other site 671143004792 motif 1; other site 671143004793 active site 671143004794 motif 2; other site 671143004795 motif 3; other site 671143004796 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 671143004797 23S rRNA binding site [nucleotide binding]; other site 671143004798 L21 binding site [polypeptide binding]; other site 671143004799 L13 binding site [polypeptide binding]; other site 671143004800 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 671143004801 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 671143004802 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 671143004803 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 671143004804 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 671143004805 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 671143004806 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 671143004807 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 671143004808 active site 671143004809 dimer interface [polypeptide binding]; other site 671143004810 motif 1; other site 671143004811 motif 2; other site 671143004812 motif 3; other site 671143004813 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 671143004814 anticodon binding site; other site 671143004815 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143004816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004817 active site 671143004818 phosphorylation site [posttranslational modification] 671143004819 intermolecular recognition site; other site 671143004820 dimerization interface [polypeptide binding]; other site 671143004821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143004822 Walker A motif; other site 671143004823 ATP binding site [chemical binding]; other site 671143004824 Walker B motif; other site 671143004825 arginine finger; other site 671143004826 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143004827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143004828 phosphorylation site [posttranslational modification] 671143004829 dimer interface [polypeptide binding]; other site 671143004830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143004831 ATP binding site [chemical binding]; other site 671143004832 Mg2+ binding site [ion binding]; other site 671143004833 G-X-G motif; other site 671143004834 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 671143004835 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 671143004836 catalytic loop [active] 671143004837 iron binding site [ion binding]; other site 671143004838 PAS domain; Region: PAS; smart00091 671143004839 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 671143004840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143004841 Walker A motif; other site 671143004842 ATP binding site [chemical binding]; other site 671143004843 Walker B motif; other site 671143004844 arginine finger; other site 671143004845 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143004846 WW domain binding protein 11; Region: Wbp11; pfam09429 671143004847 Domain of unknown function (DUF336); Region: DUF336; pfam03928 671143004848 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 671143004849 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143004850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004851 active site 671143004852 phosphorylation site [posttranslational modification] 671143004853 intermolecular recognition site; other site 671143004854 dimerization interface [polypeptide binding]; other site 671143004855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143004856 Walker A motif; other site 671143004857 ATP binding site [chemical binding]; other site 671143004858 Walker B motif; other site 671143004859 arginine finger; other site 671143004860 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143004861 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 671143004862 dimerization interface [polypeptide binding]; other site 671143004863 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 671143004864 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143004865 putative active site [active] 671143004866 heme pocket [chemical binding]; other site 671143004867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143004868 dimer interface [polypeptide binding]; other site 671143004869 phosphorylation site [posttranslational modification] 671143004870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143004871 ATP binding site [chemical binding]; other site 671143004872 Mg2+ binding site [ion binding]; other site 671143004873 G-X-G motif; other site 671143004874 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 671143004875 Response regulator receiver domain; Region: Response_reg; pfam00072 671143004876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143004877 active site 671143004878 phosphorylation site [posttranslational modification] 671143004879 intermolecular recognition site; other site 671143004880 dimerization interface [polypeptide binding]; other site 671143004881 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 671143004882 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 671143004883 substrate binding pocket [chemical binding]; other site 671143004884 membrane-bound complex binding site; other site 671143004885 hinge residues; other site 671143004886 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 671143004887 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 671143004888 Walker A/P-loop; other site 671143004889 ATP binding site [chemical binding]; other site 671143004890 Q-loop/lid; other site 671143004891 ABC transporter signature motif; other site 671143004892 Walker B; other site 671143004893 D-loop; other site 671143004894 H-loop/switch region; other site 671143004895 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 671143004896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 671143004897 dimer interface [polypeptide binding]; other site 671143004898 conserved gate region; other site 671143004899 putative PBP binding loops; other site 671143004900 ABC-ATPase subunit interface; other site 671143004901 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 671143004902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 671143004903 dimer interface [polypeptide binding]; other site 671143004904 conserved gate region; other site 671143004905 putative PBP binding loops; other site 671143004906 ABC-ATPase subunit interface; other site 671143004907 MOSC domain; Region: MOSC; pfam03473 671143004908 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 671143004909 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 671143004910 putative active site [active] 671143004911 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 671143004912 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 671143004913 Fic family protein [Function unknown]; Region: COG3177 671143004914 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 671143004915 Fic/DOC family; Region: Fic; pfam02661 671143004916 HsdM N-terminal domain; Region: HsdM_N; pfam12161 671143004917 Uncharacterized conserved protein [Function unknown]; Region: COG1656 671143004918 Protein of unknown function DUF82; Region: DUF82; pfam01927 671143004919 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 671143004920 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 671143004921 putative active site [active] 671143004922 substrate binding site [chemical binding]; other site 671143004923 putative cosubstrate binding site; other site 671143004924 catalytic site [active] 671143004925 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 671143004926 substrate binding site [chemical binding]; other site 671143004927 16S rRNA methyltransferase B; Provisional; Region: PRK14902 671143004928 putative RNA binding site [nucleotide binding]; other site 671143004929 NusB family; Region: NusB; pfam01029 671143004930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143004931 S-adenosylmethionine binding site [chemical binding]; other site 671143004932 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 671143004933 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 671143004934 Outer membrane efflux protein; Region: OEP; pfam02321 671143004935 Outer membrane efflux protein; Region: OEP; pfam02321 671143004936 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 671143004937 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 671143004938 HlyD family secretion protein; Region: HlyD_3; pfam13437 671143004939 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 671143004940 CopC domain; Region: CopC; pfam04234 671143004941 Copper resistance protein D; Region: CopD; cl00563 671143004942 Helix-turn-helix domain; Region: HTH_17; pfam12728 671143004943 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 671143004944 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 671143004945 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 671143004946 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 671143004947 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 671143004948 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 671143004949 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 671143004950 N-terminal plug; other site 671143004951 ligand-binding site [chemical binding]; other site 671143004952 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 671143004953 dimer interface [polypeptide binding]; other site 671143004954 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 671143004955 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 671143004956 HlyD family secretion protein; Region: HlyD_3; pfam13437 671143004957 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 671143004958 FtsX-like permease family; Region: FtsX; pfam02687 671143004959 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 671143004960 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 671143004961 Walker A/P-loop; other site 671143004962 ATP binding site [chemical binding]; other site 671143004963 Q-loop/lid; other site 671143004964 ABC transporter signature motif; other site 671143004965 Walker B; other site 671143004966 D-loop; other site 671143004967 H-loop/switch region; other site 671143004968 RNA polymerase sigma factor; Provisional; Region: PRK11924 671143004969 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 671143004970 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 671143004971 DNA binding residues [nucleotide binding] 671143004972 Putative zinc-finger; Region: zf-HC2; pfam13490 671143004973 Herpesviridae UL52/UL70 DNA primase; Region: Herpes_UL52; cl17300 671143004974 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 671143004975 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 671143004976 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 671143004977 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 671143004978 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 671143004979 HlyD family secretion protein; Region: HlyD_3; pfam13437 671143004980 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 671143004981 Protein export membrane protein; Region: SecD_SecF; cl14618 671143004982 Protein export membrane protein; Region: SecD_SecF; cl14618 671143004983 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 671143004984 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143004985 FeS/SAM binding site; other site 671143004986 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 671143004987 ZIP Zinc transporter; Region: Zip; pfam02535 671143004988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143004989 S-adenosylmethionine binding site [chemical binding]; other site 671143004990 YKOF-related Family; Region: Ykof; pfam07615 671143004991 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 671143004992 Cation efflux family; Region: Cation_efflux; cl00316 671143004993 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 671143004994 Beta-propeller repeat; Region: SBBP; pfam06739 671143004995 Beta-propeller repeat; Region: SBBP; pfam06739 671143004996 Beta-propeller repeat; Region: SBBP; pfam06739 671143004997 Beta-propeller repeat; Region: SBBP; pfam06739 671143004998 Beta-propeller repeat; Region: SBBP; pfam06739 671143004999 Beta-propeller repeat; Region: SBBP; pfam06739 671143005000 Cytochrome C' Region: Cytochrom_C_2; cl01610 671143005001 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 671143005002 FtsX-like permease family; Region: FtsX; pfam02687 671143005003 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 671143005004 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 671143005005 Walker A/P-loop; other site 671143005006 ATP binding site [chemical binding]; other site 671143005007 Q-loop/lid; other site 671143005008 ABC transporter signature motif; other site 671143005009 Walker B; other site 671143005010 D-loop; other site 671143005011 H-loop/switch region; other site 671143005012 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 671143005013 NosL; Region: NosL; cl01769 671143005014 NosL; Region: NosL; cl01769 671143005015 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 671143005016 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 671143005017 N-terminal plug; other site 671143005018 ligand-binding site [chemical binding]; other site 671143005019 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 671143005020 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 671143005021 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 671143005022 substrate binding pocket [chemical binding]; other site 671143005023 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 671143005024 B12 binding site [chemical binding]; other site 671143005025 cobalt ligand [ion binding]; other site 671143005026 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 671143005027 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 671143005028 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 671143005029 DEAD-like helicases superfamily; Region: DEXDc; smart00487 671143005030 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 671143005031 ATP binding site [chemical binding]; other site 671143005032 putative Mg++ binding site [ion binding]; other site 671143005033 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 671143005034 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 671143005035 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 671143005036 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 671143005037 HsdM N-terminal domain; Region: HsdM_N; pfam12161 671143005038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143005039 S-adenosylmethionine binding site [chemical binding]; other site 671143005040 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 671143005041 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 671143005042 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 671143005043 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 671143005044 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 671143005045 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 671143005046 intersubunit interface [polypeptide binding]; other site 671143005047 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 671143005048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 671143005049 Walker A/P-loop; other site 671143005050 ATP binding site [chemical binding]; other site 671143005051 Q-loop/lid; other site 671143005052 ABC transporter signature motif; other site 671143005053 Walker B; other site 671143005054 D-loop; other site 671143005055 H-loop/switch region; other site 671143005056 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 671143005057 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 671143005058 putative PBP binding regions; other site 671143005059 ABC-ATPase subunit interface; other site 671143005060 putative peroxiredoxin; Provisional; Region: PRK13190 671143005061 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 671143005062 dimer interface [polypeptide binding]; other site 671143005063 decamer (pentamer of dimers) interface [polypeptide binding]; other site 671143005064 catalytic triad [active] 671143005065 Uncharacterized conserved protein [Function unknown]; Region: COG1262 671143005066 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 671143005067 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 671143005068 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 671143005069 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 671143005070 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 671143005071 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 671143005072 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 671143005073 Substrate binding site; other site 671143005074 Mg++ binding site; other site 671143005075 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 671143005076 active site 671143005077 substrate binding site [chemical binding]; other site 671143005078 CoA binding site [chemical binding]; other site 671143005079 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 671143005080 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 671143005081 glutaminase active site [active] 671143005082 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 671143005083 dimer interface [polypeptide binding]; other site 671143005084 active site 671143005085 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 671143005086 dimer interface [polypeptide binding]; other site 671143005087 active site 671143005088 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 671143005089 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 671143005090 catalytic loop [active] 671143005091 iron binding site [ion binding]; other site 671143005092 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 671143005093 L-aspartate oxidase; Provisional; Region: PRK06175 671143005094 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 671143005095 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 671143005096 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 671143005097 malate dehydrogenase; Reviewed; Region: PRK06223 671143005098 dimer interface [polypeptide binding]; other site 671143005099 NAD(P) binding site [chemical binding]; other site 671143005100 tetramer (dimer of dimers) interface [polypeptide binding]; other site 671143005101 substrate binding site [chemical binding]; other site 671143005102 isocitrate dehydrogenase; Validated; Region: PRK07362 671143005103 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 671143005104 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 671143005105 CARDB; Region: CARDB; pfam07705 671143005106 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 671143005107 putative ADP-ribose binding site [chemical binding]; other site 671143005108 putative active site [active] 671143005109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 671143005110 dimer interface [polypeptide binding]; other site 671143005111 conserved gate region; other site 671143005112 ABC-ATPase subunit interface; other site 671143005113 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 671143005114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 671143005115 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 671143005116 Walker A/P-loop; other site 671143005117 ATP binding site [chemical binding]; other site 671143005118 Q-loop/lid; other site 671143005119 ABC transporter signature motif; other site 671143005120 Walker B; other site 671143005121 D-loop; other site 671143005122 H-loop/switch region; other site 671143005123 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 671143005124 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 671143005125 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 671143005126 active site 671143005127 catalytic residues [active] 671143005128 Int/Topo IB signature motif; other site 671143005129 DNA binding site [nucleotide binding] 671143005130 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 671143005131 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 671143005132 active site 671143005133 NTP binding site [chemical binding]; other site 671143005134 metal binding triad [ion binding]; metal-binding site 671143005135 antibiotic binding site [chemical binding]; other site 671143005136 Uncharacterized conserved protein [Function unknown]; Region: COG2361 671143005137 Protein of unknown function (DUF433); Region: DUF433; cl01030 671143005138 putative transposase OrfB; Reviewed; Region: PHA02517 671143005139 HTH-like domain; Region: HTH_21; pfam13276 671143005140 Integrase core domain; Region: rve; pfam00665 671143005141 Integrase core domain; Region: rve_3; pfam13683 671143005142 Transposase; Region: HTH_Tnp_1; pfam01527 671143005143 Predicted transcriptional regulator [Transcription]; Region: COG3905 671143005144 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 671143005145 Transposase [DNA replication, recombination, and repair]; Region: COG5421 671143005146 Transposase [DNA replication, recombination, and repair]; Region: COG5421 671143005147 Helix-turn-helix domain; Region: HTH_37; pfam13744 671143005148 non-specific DNA binding site [nucleotide binding]; other site 671143005149 salt bridge; other site 671143005150 sequence-specific DNA binding site [nucleotide binding]; other site 671143005151 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 671143005152 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 671143005153 acyl-activating enzyme (AAE) consensus motif; other site 671143005154 AMP binding site [chemical binding]; other site 671143005155 active site 671143005156 CoA binding site [chemical binding]; other site 671143005157 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 671143005158 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143005159 FeS/SAM binding site; other site 671143005160 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 671143005161 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 671143005162 CoenzymeA binding site [chemical binding]; other site 671143005163 subunit interaction site [polypeptide binding]; other site 671143005164 PHB binding site; other site 671143005165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 671143005166 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 671143005167 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 671143005168 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 671143005169 Walker A/P-loop; other site 671143005170 ATP binding site [chemical binding]; other site 671143005171 Q-loop/lid; other site 671143005172 ABC transporter signature motif; other site 671143005173 Walker B; other site 671143005174 D-loop; other site 671143005175 H-loop/switch region; other site 671143005176 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 671143005177 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 671143005178 substrate binding pocket [chemical binding]; other site 671143005179 membrane-bound complex binding site; other site 671143005180 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 671143005181 Part of AAA domain; Region: AAA_19; pfam13245 671143005182 Family description; Region: UvrD_C_2; pfam13538 671143005183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 671143005184 Walker B; other site 671143005185 D-loop; other site 671143005186 H-loop/switch region; other site 671143005187 DNA methylase; Region: N6_N4_Mtase; cl17433 671143005188 DNA methylase; Region: N6_N4_Mtase; pfam01555 671143005189 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 671143005190 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 671143005191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 671143005192 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 671143005193 Restriction endonuclease; Region: Mrr_cat; pfam04471 671143005194 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 671143005195 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 671143005196 catalytic residues [active] 671143005197 catalytic nucleophile [active] 671143005198 Recombinase; Region: Recombinase; pfam07508 671143005199 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 671143005200 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 671143005201 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143005202 FeS/SAM binding site; other site 671143005203 TPR repeat; Region: TPR_11; pfam13414 671143005204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143005205 binding surface 671143005206 TPR motif; other site 671143005207 Tetratricopeptide repeat; Region: TPR_12; pfam13424 671143005208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143005209 binding surface 671143005210 TPR repeat; Region: TPR_11; pfam13414 671143005211 TPR motif; other site 671143005212 TPR repeat; Region: TPR_11; pfam13414 671143005213 YceG-like family; Region: YceG; pfam02618 671143005214 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 671143005215 dimerization interface [polypeptide binding]; other site 671143005216 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 671143005217 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 671143005218 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 671143005219 minor groove reading motif; other site 671143005220 helix-hairpin-helix signature motif; other site 671143005221 substrate binding pocket [chemical binding]; other site 671143005222 active site 671143005223 threonine synthase; Validated; Region: PRK06260 671143005224 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 671143005225 homodimer interface [polypeptide binding]; other site 671143005226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143005227 catalytic residue [active] 671143005228 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 671143005229 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 671143005230 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 671143005231 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 671143005232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143005233 S-adenosylmethionine binding site [chemical binding]; other site 671143005234 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 671143005235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 671143005236 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 671143005237 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 671143005238 DNA binding residues [nucleotide binding] 671143005239 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 671143005240 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 671143005241 CoenzymeA binding site [chemical binding]; other site 671143005242 subunit interaction site [polypeptide binding]; other site 671143005243 PHB binding site; other site 671143005244 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 671143005245 synthetase active site [active] 671143005246 NTP binding site [chemical binding]; other site 671143005247 metal binding site [ion binding]; metal-binding site 671143005248 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 671143005249 Clostripain family; Region: Peptidase_C11; pfam03415 671143005250 CHAT domain; Region: CHAT; pfam12770 671143005251 PGAP1-like protein; Region: PGAP1; pfam07819 671143005252 Caspase domain; Region: Peptidase_C14; pfam00656 671143005253 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 671143005254 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 671143005255 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 671143005256 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 671143005257 catalytic residue [active] 671143005258 putative FPP diphosphate binding site; other site 671143005259 putative FPP binding hydrophobic cleft; other site 671143005260 dimer interface [polypeptide binding]; other site 671143005261 putative IPP diphosphate binding site; other site 671143005262 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 671143005263 Peptidase family M50; Region: Peptidase_M50; pfam02163 671143005264 active site 671143005265 putative substrate binding region [chemical binding]; other site 671143005266 TonB C terminal; Region: TonB_2; pfam13103 671143005267 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 671143005268 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 671143005269 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 671143005270 Walker A/P-loop; other site 671143005271 ATP binding site [chemical binding]; other site 671143005272 Q-loop/lid; other site 671143005273 ABC transporter signature motif; other site 671143005274 Walker B; other site 671143005275 D-loop; other site 671143005276 H-loop/switch region; other site 671143005277 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 671143005278 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 671143005279 ABC-ATPase subunit interface; other site 671143005280 dimer interface [polypeptide binding]; other site 671143005281 putative PBP binding regions; other site 671143005282 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 671143005283 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 671143005284 putative binding site residues; other site 671143005285 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 671143005286 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 671143005287 N-terminal plug; other site 671143005288 ligand-binding site [chemical binding]; other site 671143005289 cobalamin synthase; Reviewed; Region: cobS; PRK00235 671143005290 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 671143005291 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 671143005292 putative dimer interface [polypeptide binding]; other site 671143005293 active site pocket [active] 671143005294 putative cataytic base [active] 671143005295 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 671143005296 homotrimer interface [polypeptide binding]; other site 671143005297 Walker A motif; other site 671143005298 GTP binding site [chemical binding]; other site 671143005299 Walker B motif; other site 671143005300 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 671143005301 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 671143005302 putative FMN binding site [chemical binding]; other site 671143005303 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 671143005304 Transglycosylase; Region: Transgly; pfam00912 671143005305 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 671143005306 VacJ like lipoprotein; Region: VacJ; cl01073 671143005307 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 671143005308 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 671143005309 NADP binding site [chemical binding]; other site 671143005310 dimer interface [polypeptide binding]; other site 671143005311 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 671143005312 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 671143005313 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 671143005314 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 671143005315 homodimer interface [polypeptide binding]; other site 671143005316 oligonucleotide binding site [chemical binding]; other site 671143005317 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 671143005318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143005319 FeS/SAM binding site; other site 671143005320 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 671143005321 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 671143005322 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 671143005323 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 671143005324 DNA binding residues [nucleotide binding] 671143005325 dimerization interface [polypeptide binding]; other site 671143005326 Response regulator receiver domain; Region: Response_reg; pfam00072 671143005327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143005328 active site 671143005329 phosphorylation site [posttranslational modification] 671143005330 intermolecular recognition site; other site 671143005331 dimerization interface [polypeptide binding]; other site 671143005332 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 671143005333 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 671143005334 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143005335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143005336 dimer interface [polypeptide binding]; other site 671143005337 phosphorylation site [posttranslational modification] 671143005338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143005339 ATP binding site [chemical binding]; other site 671143005340 Mg2+ binding site [ion binding]; other site 671143005341 G-X-G motif; other site 671143005342 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 671143005343 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 671143005344 DNA binding residues [nucleotide binding] 671143005345 dimerization interface [polypeptide binding]; other site 671143005346 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 671143005347 dimer interface [polypeptide binding]; other site 671143005348 substrate binding site [chemical binding]; other site 671143005349 metal binding sites [ion binding]; metal-binding site 671143005350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 671143005351 Major Facilitator Superfamily; Region: MFS_1; pfam07690 671143005352 putative substrate translocation pore; other site 671143005353 phosphoribulokinase; Provisional; Region: PRK15453 671143005354 active site 671143005355 GAF domain; Region: GAF_3; pfam13492 671143005356 GAF domain; Region: GAF_2; pfam13185 671143005357 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 671143005358 GAF domain; Region: GAF_3; pfam13492 671143005359 PAS domain S-box; Region: sensory_box; TIGR00229 671143005360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143005361 putative active site [active] 671143005362 heme pocket [chemical binding]; other site 671143005363 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143005364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143005365 dimer interface [polypeptide binding]; other site 671143005366 phosphorylation site [posttranslational modification] 671143005367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143005368 ATP binding site [chemical binding]; other site 671143005369 Mg2+ binding site [ion binding]; other site 671143005370 G-X-G motif; other site 671143005371 Response regulator receiver domain; Region: Response_reg; pfam00072 671143005372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143005373 active site 671143005374 phosphorylation site [posttranslational modification] 671143005375 intermolecular recognition site; other site 671143005376 dimerization interface [polypeptide binding]; other site 671143005377 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 671143005378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143005379 FeS/SAM binding site; other site 671143005380 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 671143005381 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 671143005382 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 671143005383 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 671143005384 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 671143005385 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 671143005386 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 671143005387 Domain of unknown function DUF20; Region: UPF0118; pfam01594 671143005388 ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha...; Region: ASRGL1_like; cd04702 671143005389 catalytic nucleophile [active] 671143005390 Peptidase family M48; Region: Peptidase_M48; cl12018 671143005391 TPR repeat; Region: TPR_11; pfam13414 671143005392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 671143005393 binding surface 671143005394 TPR motif; other site 671143005395 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143005396 binding surface 671143005397 TPR motif; other site 671143005398 Tetratricopeptide repeat; Region: TPR_12; pfam13424 671143005399 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 671143005400 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 671143005401 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 671143005402 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 671143005403 Walker A/P-loop; other site 671143005404 ATP binding site [chemical binding]; other site 671143005405 Q-loop/lid; other site 671143005406 ABC transporter signature motif; other site 671143005407 Walker B; other site 671143005408 D-loop; other site 671143005409 H-loop/switch region; other site 671143005410 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 671143005411 carboxyltransferase (CT) interaction site; other site 671143005412 HlyD family secretion protein; Region: HlyD_3; pfam13437 671143005413 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 671143005414 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 671143005415 nucleotide binding pocket [chemical binding]; other site 671143005416 K-X-D-G motif; other site 671143005417 catalytic site [active] 671143005418 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 671143005419 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 671143005420 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 671143005421 Dimer interface [polypeptide binding]; other site 671143005422 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 671143005423 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 671143005424 active site 671143005425 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 671143005426 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 671143005427 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 671143005428 dihydroorotase; Validated; Region: pyrC; PRK09357 671143005429 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 671143005430 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 671143005431 active site 671143005432 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 671143005433 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 671143005434 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 671143005435 catalytic site [active] 671143005436 subunit interface [polypeptide binding]; other site 671143005437 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 671143005438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143005439 S-adenosylmethionine binding site [chemical binding]; other site 671143005440 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 671143005441 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 671143005442 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 671143005443 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 671143005444 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 671143005445 ATP-grasp domain; Region: ATP-grasp_4; cl17255 671143005446 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 671143005447 IMP binding site; other site 671143005448 dimer interface [polypeptide binding]; other site 671143005449 partial ornithine binding site; other site 671143005450 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 671143005451 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 671143005452 FAD binding pocket [chemical binding]; other site 671143005453 FAD binding motif [chemical binding]; other site 671143005454 phosphate binding motif [ion binding]; other site 671143005455 beta-alpha-beta structure motif; other site 671143005456 NAD binding pocket [chemical binding]; other site 671143005457 Iron coordination center [ion binding]; other site 671143005458 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 671143005459 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 671143005460 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 671143005461 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 671143005462 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 671143005463 homodimer interface [polypeptide binding]; other site 671143005464 substrate-cofactor binding pocket; other site 671143005465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143005466 catalytic residue [active] 671143005467 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 671143005468 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 671143005469 heterodimer interface [polypeptide binding]; other site 671143005470 active site 671143005471 FMN binding site [chemical binding]; other site 671143005472 homodimer interface [polypeptide binding]; other site 671143005473 substrate binding site [chemical binding]; other site 671143005474 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 671143005475 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 671143005476 minor groove reading motif; other site 671143005477 helix-hairpin-helix signature motif; other site 671143005478 substrate binding pocket [chemical binding]; other site 671143005479 active site 671143005480 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 671143005481 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 671143005482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 671143005483 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 671143005484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143005485 Walker A motif; other site 671143005486 ATP binding site [chemical binding]; other site 671143005487 Walker B motif; other site 671143005488 fructose-1,6-bisphosphatase family protein; Region: PLN02628 671143005489 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 671143005490 AMP binding site [chemical binding]; other site 671143005491 metal binding site [ion binding]; metal-binding site 671143005492 active site 671143005493 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 671143005494 tetramer (dimer of dimers) interface [polypeptide binding]; other site 671143005495 active site 671143005496 dimer interface [polypeptide binding]; other site 671143005497 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 671143005498 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 671143005499 homodimer interface [polypeptide binding]; other site 671143005500 active site 671143005501 heterodimer interface [polypeptide binding]; other site 671143005502 catalytic residue [active] 671143005503 metal binding site [ion binding]; metal-binding site 671143005504 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 671143005505 multimerization interface [polypeptide binding]; other site 671143005506 CbbX; Provisional; Region: cbbX; CHL00181 671143005507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143005508 Walker A motif; other site 671143005509 ATP binding site [chemical binding]; other site 671143005510 Walker B motif; other site 671143005511 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 671143005512 Phosphoenolpyruvate carboxylase; Region: PEPcase_2; pfam14010 671143005513 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 671143005514 active site clefts [active] 671143005515 zinc binding site [ion binding]; other site 671143005516 dimer interface [polypeptide binding]; other site 671143005517 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 671143005518 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 671143005519 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 671143005520 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 671143005521 active site 671143005522 Int/Topo IB signature motif; other site 671143005523 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 671143005524 alanine racemase; Reviewed; Region: alr; PRK00053 671143005525 active site 671143005526 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 671143005527 dimer interface [polypeptide binding]; other site 671143005528 substrate binding site [chemical binding]; other site 671143005529 catalytic residues [active] 671143005530 trigger factor; Provisional; Region: tig; PRK01490 671143005531 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 671143005532 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 671143005533 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 671143005534 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 671143005535 oligomer interface [polypeptide binding]; other site 671143005536 active site residues [active] 671143005537 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 671143005538 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 671143005539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143005540 Walker A motif; other site 671143005541 ATP binding site [chemical binding]; other site 671143005542 Walker B motif; other site 671143005543 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 671143005544 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 671143005545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143005546 binding surface 671143005547 TPR motif; other site 671143005548 Tetratricopeptide repeat; Region: TPR_6; pfam13174 671143005549 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 671143005550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143005551 S-adenosylmethionine binding site [chemical binding]; other site 671143005552 thiamine monophosphate kinase; Provisional; Region: PRK05731 671143005553 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 671143005554 ATP binding site [chemical binding]; other site 671143005555 dimerization interface [polypeptide binding]; other site 671143005556 enolase; Provisional; Region: eno; PRK00077 671143005557 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 671143005558 dimer interface [polypeptide binding]; other site 671143005559 metal binding site [ion binding]; metal-binding site 671143005560 substrate binding pocket [chemical binding]; other site 671143005561 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 671143005562 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 671143005563 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 671143005564 NAD(P) binding site [chemical binding]; other site 671143005565 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 671143005566 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 671143005567 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 671143005568 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 671143005569 active site 671143005570 NTP binding site [chemical binding]; other site 671143005571 metal binding triad [ion binding]; metal-binding site 671143005572 antibiotic binding site [chemical binding]; other site 671143005573 Protein of unknown function DUF86; Region: DUF86; pfam01934 671143005574 EthD domain; Region: EthD; cl17553 671143005575 flavoprotein, HI0933 family; Region: TIGR00275 671143005576 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 671143005577 ABC transporter ATPase component; Reviewed; Region: PRK11147 671143005578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 671143005579 Walker A/P-loop; other site 671143005580 ATP binding site [chemical binding]; other site 671143005581 ABC transporter signature motif; other site 671143005582 Walker B; other site 671143005583 D-loop; other site 671143005584 H-loop/switch region; other site 671143005585 ABC transporter; Region: ABC_tran_2; pfam12848 671143005586 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 671143005587 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 671143005588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 671143005589 Walker A/P-loop; other site 671143005590 ATP binding site [chemical binding]; other site 671143005591 Q-loop/lid; other site 671143005592 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 671143005593 ABC transporter; Region: ABC_tran_2; pfam12848 671143005594 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 671143005595 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 671143005596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 671143005597 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 671143005598 Cupin domain; Region: Cupin_2; pfam07883 671143005599 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 671143005600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 671143005601 ATP binding site [chemical binding]; other site 671143005602 putative Mg++ binding site [ion binding]; other site 671143005603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 671143005604 nucleotide binding region [chemical binding]; other site 671143005605 ATP-binding site [chemical binding]; other site 671143005606 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 671143005607 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 671143005608 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 671143005609 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 671143005610 mce related protein; Region: MCE; pfam02470 671143005611 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 671143005612 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 671143005613 Walker A/P-loop; other site 671143005614 ATP binding site [chemical binding]; other site 671143005615 Q-loop/lid; other site 671143005616 ABC transporter signature motif; other site 671143005617 Walker B; other site 671143005618 D-loop; other site 671143005619 H-loop/switch region; other site 671143005620 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 671143005621 Permease; Region: Permease; pfam02405 671143005622 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 671143005623 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 671143005624 YcfA-like protein; Region: YcfA; cl00752 671143005625 YcfA-like protein; Region: YcfA; pfam07927 671143005626 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 671143005627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 671143005628 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 671143005629 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 671143005630 YcfA-like protein; Region: YcfA; pfam07927 671143005631 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 671143005632 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 671143005633 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 671143005634 metal binding site [ion binding]; metal-binding site 671143005635 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 671143005636 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 671143005637 substrate binding site [chemical binding]; other site 671143005638 glutamase interaction surface [polypeptide binding]; other site 671143005639 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 671143005640 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 671143005641 catalytic residues [active] 671143005642 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3062174; Product type e : enzyme 671143005643 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3062174; Product type e : enzyme 671143005644 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 671143005645 putative active site pocket [active] 671143005646 4-fold oligomerization interface [polypeptide binding]; other site 671143005647 metal binding residues [ion binding]; metal-binding site 671143005648 3-fold/trimer interface [polypeptide binding]; other site 671143005649 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 671143005650 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 671143005651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143005652 homodimer interface [polypeptide binding]; other site 671143005653 catalytic residue [active] 671143005654 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 671143005655 histidinol dehydrogenase; Region: hisD; TIGR00069 671143005656 NAD binding site [chemical binding]; other site 671143005657 dimerization interface [polypeptide binding]; other site 671143005658 product binding site; other site 671143005659 substrate binding site [chemical binding]; other site 671143005660 zinc binding site [ion binding]; other site 671143005661 catalytic residues [active] 671143005662 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 671143005663 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 671143005664 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 671143005665 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 671143005666 hinge; other site 671143005667 active site 671143005668 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 671143005669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143005670 S-adenosylmethionine binding site [chemical binding]; other site 671143005671 peptide chain release factor 1; Validated; Region: prfA; PRK00591 671143005672 This domain is found in peptide chain release factors; Region: PCRF; smart00937 671143005673 RF-1 domain; Region: RF-1; pfam00472 671143005674 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 671143005675 transcription termination factor Rho; Provisional; Region: rho; PRK09376 671143005676 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 671143005677 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 671143005678 RNA binding site [nucleotide binding]; other site 671143005679 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 671143005680 multimer interface [polypeptide binding]; other site 671143005681 Walker A motif; other site 671143005682 ATP binding site [chemical binding]; other site 671143005683 Walker B motif; other site 671143005684 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 671143005685 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 671143005686 CoA-binding site [chemical binding]; other site 671143005687 ATP-binding [chemical binding]; other site 671143005688 DNA polymerase I; Provisional; Region: PRK05755 671143005689 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 671143005690 active site 671143005691 metal binding site 1 [ion binding]; metal-binding site 671143005692 putative 5' ssDNA interaction site; other site 671143005693 metal binding site 3; metal-binding site 671143005694 metal binding site 2 [ion binding]; metal-binding site 671143005695 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 671143005696 putative DNA binding site [nucleotide binding]; other site 671143005697 putative metal binding site [ion binding]; other site 671143005698 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 671143005699 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 671143005700 active site 671143005701 DNA binding site [nucleotide binding] 671143005702 catalytic site [active] 671143005703 chaperone protein DnaJ; Provisional; Region: PRK10767 671143005704 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 671143005705 HSP70 interaction site [polypeptide binding]; other site 671143005706 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 671143005707 substrate binding site [polypeptide binding]; other site 671143005708 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 671143005709 Zn binding sites [ion binding]; other site 671143005710 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 671143005711 dimer interface [polypeptide binding]; other site 671143005712 GrpE; Region: GrpE; pfam01025 671143005713 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 671143005714 dimer interface [polypeptide binding]; other site 671143005715 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 671143005716 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 671143005717 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 671143005718 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 671143005719 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 671143005720 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 671143005721 Catalytic site [active] 671143005722 GTP-binding protein LepA; Provisional; Region: PRK05433 671143005723 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 671143005724 G1 box; other site 671143005725 putative GEF interaction site [polypeptide binding]; other site 671143005726 GTP/Mg2+ binding site [chemical binding]; other site 671143005727 Switch I region; other site 671143005728 G2 box; other site 671143005729 G3 box; other site 671143005730 Switch II region; other site 671143005731 G4 box; other site 671143005732 G5 box; other site 671143005733 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 671143005734 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 671143005735 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 671143005736 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 671143005737 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 671143005738 substrate binding pocket [chemical binding]; other site 671143005739 chain length determination region; other site 671143005740 substrate-Mg2+ binding site; other site 671143005741 catalytic residues [active] 671143005742 aspartate-rich region 1; other site 671143005743 active site lid residues [active] 671143005744 aspartate-rich region 2; other site 671143005745 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 671143005746 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 671143005747 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 671143005748 active site 671143005749 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 671143005750 Short C-terminal domain; Region: SHOCT; pfam09851 671143005751 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 671143005752 TrkA-N domain; Region: TrkA_N; pfam02254 671143005753 TrkA-C domain; Region: TrkA_C; pfam02080 671143005754 Ion channel; Region: Ion_trans_2; pfam07885 671143005755 TrkA-N domain; Region: TrkA_N; pfam02254 671143005756 intracellular protease, PfpI family; Region: PfpI; TIGR01382 671143005757 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 671143005758 conserved cys residue [active] 671143005759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143005760 non-specific DNA binding site [nucleotide binding]; other site 671143005761 salt bridge; other site 671143005762 sequence-specific DNA binding site [nucleotide binding]; other site 671143005763 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 671143005764 Uncharacterized conserved protein [Function unknown]; Region: COG2353 671143005765 Bacterial SH3 domain; Region: SH3_3; cl17532 671143005766 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 671143005767 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 671143005768 putative active site [active] 671143005769 homotetrameric interface [polypeptide binding]; other site 671143005770 metal binding site [ion binding]; metal-binding site 671143005771 Protein of unknown function, DUF488; Region: DUF488; cl01246 671143005772 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 671143005773 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 671143005774 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 671143005775 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 671143005776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 671143005777 motif II; other site 671143005778 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 671143005779 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 671143005780 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 671143005781 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 671143005782 Mechanosensitive ion channel; Region: MS_channel; pfam00924 671143005783 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 671143005784 Transcriptional regulator [Transcription]; Region: IclR; COG1414 671143005785 Bacterial transcriptional regulator; Region: IclR; pfam01614 671143005786 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 671143005787 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 671143005788 catalytic residue [active] 671143005789 cell division protein FtsZ; Validated; Region: PRK09330 671143005790 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 671143005791 nucleotide binding site [chemical binding]; other site 671143005792 SulA interaction site; other site 671143005793 cell division protein FtsA; Region: ftsA; TIGR01174 671143005794 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 671143005795 nucleotide binding site [chemical binding]; other site 671143005796 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 671143005797 Cell division protein FtsA; Region: FtsA; pfam14450 671143005798 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 671143005799 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 671143005800 FAD binding domain; Region: FAD_binding_4; pfam01565 671143005801 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 671143005802 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 671143005803 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 671143005804 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 671143005805 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 671143005806 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 671143005807 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 671143005808 active site 671143005809 homodimer interface [polypeptide binding]; other site 671143005810 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 671143005811 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 671143005812 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 671143005813 NAD(P) binding pocket [chemical binding]; other site 671143005814 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 671143005815 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 671143005816 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 671143005817 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 671143005818 Mg++ binding site [ion binding]; other site 671143005819 putative catalytic motif [active] 671143005820 putative substrate binding site [chemical binding]; other site 671143005821 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 671143005822 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 671143005823 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 671143005824 ATP-grasp domain; Region: ATP-grasp_4; cl17255 671143005825 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 671143005826 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 671143005827 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 671143005828 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 671143005829 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 671143005830 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 671143005831 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 671143005832 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 671143005833 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 671143005834 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 671143005835 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 671143005836 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 671143005837 Cell division protein FtsL; Region: FtsL; cl11433 671143005838 MraW methylase family; Region: Methyltransf_5; cl17771 671143005839 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 671143005840 cell division protein MraZ; Reviewed; Region: PRK00326 671143005841 MraZ protein; Region: MraZ; pfam02381 671143005842 MraZ protein; Region: MraZ; pfam02381 671143005843 pantoate--beta-alanine ligase; Region: panC; TIGR00018 671143005844 Pantoate-beta-alanine ligase; Region: PanC; cd00560 671143005845 active site 671143005846 ATP-binding site [chemical binding]; other site 671143005847 pantoate-binding site; other site 671143005848 HXXH motif; other site 671143005849 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 671143005850 active site 671143005851 oligomerization interface [polypeptide binding]; other site 671143005852 metal binding site [ion binding]; metal-binding site 671143005853 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 671143005854 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 671143005855 Substrate-binding site [chemical binding]; other site 671143005856 Substrate specificity [chemical binding]; other site 671143005857 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 671143005858 catalytic center binding site [active] 671143005859 ATP binding site [chemical binding]; other site 671143005860 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 671143005861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 671143005862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143005863 homodimer interface [polypeptide binding]; other site 671143005864 catalytic residue [active] 671143005865 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 671143005866 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 671143005867 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 671143005868 dihydrodipicolinate reductase; Provisional; Region: PRK00048 671143005869 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 671143005870 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 671143005871 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 671143005872 dihydrodipicolinate synthase; Region: dapA; TIGR00674 671143005873 dimer interface [polypeptide binding]; other site 671143005874 active site 671143005875 catalytic residue [active] 671143005876 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 671143005877 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 671143005878 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 671143005879 diaminopimelate decarboxylase; Region: lysA; TIGR01048 671143005880 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 671143005881 active site 671143005882 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 671143005883 substrate binding site [chemical binding]; other site 671143005884 catalytic residues [active] 671143005885 dimer interface [polypeptide binding]; other site 671143005886 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 671143005887 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 671143005888 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 671143005889 ATP binding site [chemical binding]; other site 671143005890 putative Mg++ binding site [ion binding]; other site 671143005891 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 671143005892 Divergent AAA domain; Region: AAA_4; pfam04326 671143005893 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 671143005894 Restriction endonuclease; Region: Mrr_cat; pfam04471 671143005895 TIR domain; Region: TIR_2; pfam13676 671143005896 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 671143005897 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 671143005898 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 671143005899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143005900 non-specific DNA binding site [nucleotide binding]; other site 671143005901 salt bridge; other site 671143005902 sequence-specific DNA binding site [nucleotide binding]; other site 671143005903 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 671143005904 HsdM N-terminal domain; Region: HsdM_N; pfam12161 671143005905 Methyltransferase domain; Region: Methyltransf_26; pfam13659 671143005906 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 671143005907 DNA-binding site [nucleotide binding]; DNA binding site 671143005908 RNA-binding motif; other site 671143005909 excinuclease ABC subunit B; Provisional; Region: PRK05298 671143005910 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 671143005911 ATP binding site [chemical binding]; other site 671143005912 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 671143005913 nucleotide binding region [chemical binding]; other site 671143005914 ATP-binding site [chemical binding]; other site 671143005915 Ultra-violet resistance protein B; Region: UvrB; pfam12344 671143005916 UvrB/uvrC motif; Region: UVR; pfam02151 671143005917 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 671143005918 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 671143005919 active site 671143005920 exopolyphosphatase; Region: exo_poly_only; TIGR03706 671143005921 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 671143005922 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 671143005923 Domain of unknown function (DUF814); Region: DUF814; pfam05670 671143005924 Transcriptional regulators [Transcription]; Region: MarR; COG1846 671143005925 MarR family; Region: MarR_2; pfam12802 671143005926 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; cl04829 671143005927 4Fe-4S binding domain; Region: Fer4; cl02805 671143005928 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 671143005929 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 671143005930 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 671143005931 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 671143005932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 671143005933 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 671143005934 NAD(P) binding site [chemical binding]; other site 671143005935 active site 671143005936 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 671143005937 O-Antigen ligase; Region: Wzy_C; pfam04932 671143005938 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 671143005939 HSP70 interaction site [polypeptide binding]; other site 671143005940 Protein of unknown function DUF45; Region: DUF45; cl00636 671143005941 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 671143005942 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 671143005943 putative NAD(P) binding site [chemical binding]; other site 671143005944 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 671143005945 TIGR01777 family protein; Region: yfcH 671143005946 putative NAD(P) binding site [chemical binding]; other site 671143005947 putative active site [active] 671143005948 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 671143005949 hypothetical protein; Provisional; Region: PRK05849 671143005950 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 671143005951 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 671143005952 Peptidase family U32; Region: Peptidase_U32; pfam01136 671143005953 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 671143005954 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 671143005955 membrane-bound complex binding site; other site 671143005956 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 671143005957 Peptidase family U32; Region: Peptidase_U32; pfam01136 671143005958 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 671143005959 Peptidase family U32; Region: Peptidase_U32; pfam01136 671143005960 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 671143005961 Peptidase family U32; Region: Peptidase_U32; pfam01136 671143005962 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 671143005963 active site 671143005964 NTP binding site [chemical binding]; other site 671143005965 metal binding triad [ion binding]; metal-binding site 671143005966 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 671143005967 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 671143005968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143005969 homodimer interface [polypeptide binding]; other site 671143005970 catalytic residue [active] 671143005971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143005972 PAS domain; Region: PAS_9; pfam13426 671143005973 putative active site [active] 671143005974 heme pocket [chemical binding]; other site 671143005975 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 671143005976 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 671143005977 DNA binding residues [nucleotide binding] 671143005978 dimerization interface [polypeptide binding]; other site 671143005979 BON domain; Region: BON; pfam04972 671143005980 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 671143005981 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 671143005982 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 671143005983 dimer interface [polypeptide binding]; other site 671143005984 ribonuclease Z; Provisional; Region: PRK02126 671143005985 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 671143005986 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 671143005987 putative active site [active] 671143005988 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 671143005989 NADPH bind site [chemical binding]; other site 671143005990 putative FMN binding site [chemical binding]; other site 671143005991 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 671143005992 putative FMN binding site [chemical binding]; other site 671143005993 NADPH bind site [chemical binding]; other site 671143005994 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 671143005995 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 671143005996 NAD(P) binding site [chemical binding]; other site 671143005997 catalytic residues [active] 671143005998 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 671143005999 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143006000 FeS/SAM binding site; other site 671143006001 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 671143006002 Ferredoxin [Energy production and conversion]; Region: COG1146 671143006003 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 671143006004 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 671143006005 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 671143006006 trimerization site [polypeptide binding]; other site 671143006007 active site 671143006008 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 671143006009 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 671143006010 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 671143006011 catalytic residue [active] 671143006012 FeS assembly protein SufD; Region: sufD; TIGR01981 671143006013 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 671143006014 FeS assembly ATPase SufC; Region: sufC; TIGR01978 671143006015 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 671143006016 Walker A/P-loop; other site 671143006017 ATP binding site [chemical binding]; other site 671143006018 Q-loop/lid; other site 671143006019 ABC transporter signature motif; other site 671143006020 Walker B; other site 671143006021 D-loop; other site 671143006022 H-loop/switch region; other site 671143006023 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 671143006024 putative ABC transporter; Region: ycf24; CHL00085 671143006025 Domain of unknown function DUF59; Region: DUF59; pfam01883 671143006026 antiporter inner membrane protein; Provisional; Region: PRK11670 671143006027 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 671143006028 Response regulator receiver domain; Region: Response_reg; pfam00072 671143006029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143006030 active site 671143006031 phosphorylation site [posttranslational modification] 671143006032 intermolecular recognition site; other site 671143006033 dimerization interface [polypeptide binding]; other site 671143006034 Protein of unknown function (DUF497); Region: DUF497; pfam04365 671143006035 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 671143006036 active site 671143006037 NTP binding site [chemical binding]; other site 671143006038 metal binding triad [ion binding]; metal-binding site 671143006039 antibiotic binding site [chemical binding]; other site 671143006040 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 671143006041 Peptidase family M23; Region: Peptidase_M23; pfam01551 671143006042 hypothetical protein; Validated; Region: PRK00110 671143006043 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 671143006044 active site 671143006045 putative DNA-binding cleft [nucleotide binding]; other site 671143006046 dimer interface [polypeptide binding]; other site 671143006047 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 671143006048 RuvA N terminal domain; Region: RuvA_N; pfam01330 671143006049 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 671143006050 helix-hairpin-helix signature motif; other site 671143006051 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 671143006052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143006053 Walker A motif; other site 671143006054 ATP binding site [chemical binding]; other site 671143006055 Walker B motif; other site 671143006056 arginine finger; other site 671143006057 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 671143006058 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 671143006059 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 671143006060 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 671143006061 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 671143006062 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 671143006063 Preprotein translocase subunit; Region: YajC; pfam02699 671143006064 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 671143006065 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 671143006066 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 671143006067 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 671143006068 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 671143006069 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 671143006070 [4Fe-4S] binding site [ion binding]; other site 671143006071 molybdopterin cofactor binding site; other site 671143006072 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 671143006073 molybdopterin cofactor binding site; other site 671143006074 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 671143006075 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 671143006076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143006077 FeS/SAM binding site; other site 671143006078 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 671143006079 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 671143006080 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 671143006081 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 671143006082 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 671143006083 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 671143006084 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 671143006085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143006086 binding surface 671143006087 TPR motif; other site 671143006088 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 671143006089 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 671143006090 N-acetyl-D-glucosamine binding site [chemical binding]; other site 671143006091 catalytic residue [active] 671143006092 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 671143006093 Flavoprotein; Region: Flavoprotein; pfam02441 671143006094 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 671143006095 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 671143006096 Fe-S cluster binding site [ion binding]; other site 671143006097 active site 671143006098 Cna protein B-type domain; Region: Cna_B; pfam05738 671143006099 primosomal protein N' Region: priA; TIGR00595 671143006100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 671143006101 ATP binding site [chemical binding]; other site 671143006102 putative Mg++ binding site [ion binding]; other site 671143006103 helicase superfamily c-terminal domain; Region: HELICc; smart00490 671143006104 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 671143006105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143006106 S-adenosylmethionine binding site [chemical binding]; other site 671143006107 Predicted amidohydrolase [General function prediction only]; Region: COG0388 671143006108 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 671143006109 putative active site [active] 671143006110 catalytic triad [active] 671143006111 putative dimer interface [polypeptide binding]; other site 671143006112 NAD synthetase; Provisional; Region: PRK13980 671143006113 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 671143006114 homodimer interface [polypeptide binding]; other site 671143006115 NAD binding pocket [chemical binding]; other site 671143006116 ATP binding pocket [chemical binding]; other site 671143006117 Mg binding site [ion binding]; other site 671143006118 active-site loop [active] 671143006119 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 671143006120 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 671143006121 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 671143006122 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 671143006123 Binuclear center (active site) [active] 671143006124 Putative proton exit pathway; other site 671143006125 Putative water exit pathway; other site 671143006126 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 671143006127 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 671143006128 Binuclear center (active site) [active] 671143006129 Putative proton exit pathway; other site 671143006130 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143006131 PAS domain; Region: PAS_9; pfam13426 671143006132 putative active site [active] 671143006133 heme pocket [chemical binding]; other site 671143006134 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 671143006135 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 671143006136 DNA binding residues [nucleotide binding] 671143006137 dimerization interface [polypeptide binding]; other site 671143006138 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 671143006139 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 671143006140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143006141 Walker A motif; other site 671143006142 ATP binding site [chemical binding]; other site 671143006143 Walker B motif; other site 671143006144 arginine finger; other site 671143006145 Peptidase family M41; Region: Peptidase_M41; pfam01434 671143006146 methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079 671143006147 Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744 671143006148 Ammonia monooxygenase; Region: AMO; pfam02461 671143006149 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; cl04829 671143006150 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 671143006151 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 671143006152 catalytic loop [active] 671143006153 iron binding site [ion binding]; other site 671143006154 PAS domain; Region: PAS; smart00091 671143006155 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 671143006156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143006157 Walker A motif; other site 671143006158 ATP binding site [chemical binding]; other site 671143006159 Walker B motif; other site 671143006160 arginine finger; other site 671143006161 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143006162 helicase 45; Provisional; Region: PTZ00424 671143006163 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 671143006164 ATP binding site [chemical binding]; other site 671143006165 Mg++ binding site [ion binding]; other site 671143006166 motif III; other site 671143006167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 671143006168 nucleotide binding region [chemical binding]; other site 671143006169 ATP-binding site [chemical binding]; other site 671143006170 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 671143006171 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 671143006172 ring oligomerisation interface [polypeptide binding]; other site 671143006173 ATP/Mg binding site [chemical binding]; other site 671143006174 stacking interactions; other site 671143006175 hinge regions; other site 671143006176 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 671143006177 oligomerisation interface [polypeptide binding]; other site 671143006178 mobile loop; other site 671143006179 roof hairpin; other site 671143006180 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 671143006181 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 671143006182 active site 671143006183 Substrate binding site; other site 671143006184 Mg++ binding site; other site 671143006185 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 671143006186 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 671143006187 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 671143006188 active site 671143006189 substrate binding site [chemical binding]; other site 671143006190 metal binding site [ion binding]; metal-binding site 671143006191 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 671143006192 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 671143006193 active site 671143006194 substrate binding site [chemical binding]; other site 671143006195 metal binding site [ion binding]; metal-binding site 671143006196 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 671143006197 Septum formation initiator; Region: DivIC; pfam04977 671143006198 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 671143006199 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 671143006200 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 671143006201 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 671143006202 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 671143006203 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 671143006204 active site 671143006205 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 671143006206 protein binding site [polypeptide binding]; other site 671143006207 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 671143006208 putative substrate binding region [chemical binding]; other site 671143006209 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 671143006210 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 671143006211 prolyl-tRNA synthetase; Provisional; Region: PRK09194 671143006212 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 671143006213 dimer interface [polypeptide binding]; other site 671143006214 motif 1; other site 671143006215 active site 671143006216 motif 2; other site 671143006217 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 671143006218 putative deacylase active site [active] 671143006219 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 671143006220 active site 671143006221 motif 3; other site 671143006222 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 671143006223 anticodon binding site; other site 671143006224 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 671143006225 Aspartase; Region: Aspartase; cd01357 671143006226 active sites [active] 671143006227 tetramer interface [polypeptide binding]; other site 671143006228 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 671143006229 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 671143006230 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 671143006231 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 671143006232 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 671143006233 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 671143006234 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 671143006235 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 671143006236 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 671143006237 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 671143006238 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 671143006239 Verru_Chthon cassette protein A; Region: Verru_Chthon_A; TIGR02600 671143006240 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 671143006241 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 671143006242 general secretion pathway protein J; Validated; Region: PRK08808 671143006243 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 671143006244 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 671143006245 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 671143006246 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 671143006247 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 671143006248 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 671143006249 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 671143006250 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 671143006251 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 671143006252 type II secretion system protein E; Region: type_II_gspE; TIGR02533 671143006253 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 671143006254 Walker A motif; other site 671143006255 ATP binding site [chemical binding]; other site 671143006256 Walker B motif; other site 671143006257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 671143006258 NAD(P) binding site [chemical binding]; other site 671143006259 active site 671143006260 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 671143006261 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 671143006262 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 671143006263 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 671143006264 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 671143006265 Walker A/P-loop; other site 671143006266 ATP binding site [chemical binding]; other site 671143006267 Q-loop/lid; other site 671143006268 ABC transporter signature motif; other site 671143006269 Walker B; other site 671143006270 D-loop; other site 671143006271 H-loop/switch region; other site 671143006272 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 671143006273 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 671143006274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 671143006275 Walker A/P-loop; other site 671143006276 ATP binding site [chemical binding]; other site 671143006277 Q-loop/lid; other site 671143006278 ABC transporter signature motif; other site 671143006279 Walker B; other site 671143006280 D-loop; other site 671143006281 H-loop/switch region; other site 671143006282 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 671143006283 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 671143006284 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 671143006285 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143006286 FeS/SAM binding site; other site 671143006287 malate dehydrogenase; Provisional; Region: PRK13529 671143006288 Malic enzyme, N-terminal domain; Region: malic; pfam00390 671143006289 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 671143006290 NAD(P) binding site [chemical binding]; other site 671143006291 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 671143006292 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 671143006293 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143006294 non-specific DNA binding site [nucleotide binding]; other site 671143006295 salt bridge; other site 671143006296 sequence-specific DNA binding site [nucleotide binding]; other site 671143006297 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 671143006298 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 671143006299 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 671143006300 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 671143006301 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 671143006302 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 671143006303 FOG: CBS domain [General function prediction only]; Region: COG0517 671143006304 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 671143006305 indolepyruvate/phenylpyruvate decarboxylase, Azospirillum family; Region: indol_phenyl_DC; TIGR03394 671143006306 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 671143006307 dimer interface [polypeptide binding]; other site 671143006308 PYR/PP interface [polypeptide binding]; other site 671143006309 TPP binding site [chemical binding]; other site 671143006310 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 671143006311 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 671143006312 TPP-binding site [chemical binding]; other site 671143006313 AAA domain; Region: AAA_14; pfam13173 671143006314 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 671143006315 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 671143006316 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 671143006317 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 671143006318 Ligand Binding Site [chemical binding]; other site 671143006319 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 671143006320 putative active site [active] 671143006321 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 671143006322 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 671143006323 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 671143006324 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 671143006325 substrate binding site [chemical binding]; other site 671143006326 ATP binding site [chemical binding]; other site 671143006327 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 671143006328 endonuclease IV; Provisional; Region: PRK01060 671143006329 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 671143006330 AP (apurinic/apyrimidinic) site pocket; other site 671143006331 DNA interaction; other site 671143006332 Metal-binding active site; metal-binding site 671143006333 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 671143006334 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 671143006335 Walker A/P-loop; other site 671143006336 ATP binding site [chemical binding]; other site 671143006337 Q-loop/lid; other site 671143006338 ABC transporter signature motif; other site 671143006339 Walker B; other site 671143006340 D-loop; other site 671143006341 H-loop/switch region; other site 671143006342 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 671143006343 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 671143006344 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 671143006345 Peptidase family M23; Region: Peptidase_M23; pfam01551 671143006346 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 671143006347 C-terminal peptidase (prc); Region: prc; TIGR00225 671143006348 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 671143006349 protein binding site [polypeptide binding]; other site 671143006350 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 671143006351 Catalytic dyad [active] 671143006352 UGMP family protein; Validated; Region: PRK09604 671143006353 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 671143006354 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 671143006355 active site 671143006356 catalytic residues [active] 671143006357 metal binding site [ion binding]; metal-binding site 671143006358 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 671143006359 SurA N-terminal domain; Region: SurA_N; pfam09312 671143006360 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 671143006361 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 671143006362 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 671143006363 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 671143006364 ATP binding site [chemical binding]; other site 671143006365 putative Mg++ binding site [ion binding]; other site 671143006366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 671143006367 nucleotide binding region [chemical binding]; other site 671143006368 ATP-binding site [chemical binding]; other site 671143006369 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 671143006370 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 671143006371 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 671143006372 active site 671143006373 nucleotide binding site [chemical binding]; other site 671143006374 HIGH motif; other site 671143006375 KMSKS motif; other site 671143006376 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 671143006377 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 671143006378 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 671143006379 ligand binding site [chemical binding]; other site 671143006380 CopC domain; Region: CopC; pfam04234 671143006381 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 671143006382 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 671143006383 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 671143006384 HlyD family secretion protein; Region: HlyD_3; pfam13437 671143006385 Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Region: PurM; COG0150 671143006386 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 671143006387 dimerization interface [polypeptide binding]; other site 671143006388 putative ATP binding site [chemical binding]; other site 671143006389 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 671143006390 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 671143006391 YcfA-like protein; Region: YcfA; cl00752 671143006392 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 671143006393 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 671143006394 putative active site [active] 671143006395 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 671143006396 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 671143006397 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 671143006398 recombination factor protein RarA; Reviewed; Region: PRK13342 671143006399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143006400 Walker A motif; other site 671143006401 ATP binding site [chemical binding]; other site 671143006402 Walker B motif; other site 671143006403 arginine finger; other site 671143006404 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 671143006405 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 671143006406 active site 671143006407 dimer interface [polypeptide binding]; other site 671143006408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143006409 TPR motif; other site 671143006410 binding surface 671143006411 Tetratricopeptide repeat; Region: TPR_12; pfam13424 671143006412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143006413 binding surface 671143006414 TPR motif; other site 671143006415 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 671143006416 glycogen synthase; Provisional; Region: glgA; PRK00654 671143006417 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 671143006418 ADP-binding pocket [chemical binding]; other site 671143006419 homodimer interface [polypeptide binding]; other site 671143006420 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 671143006421 SmpB-tmRNA interface; other site 671143006422 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 671143006423 IHF dimer interface [polypeptide binding]; other site 671143006424 IHF - DNA interface [nucleotide binding]; other site 671143006425 YacP-like NYN domain; Region: NYN_YacP; pfam05991 671143006426 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 671143006427 active site 671143006428 thiamine phosphate binding site [chemical binding]; other site 671143006429 pyrophosphate binding site [ion binding]; other site 671143006430 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 671143006431 ThiS interaction site; other site 671143006432 putative active site [active] 671143006433 tetramer interface [polypeptide binding]; other site 671143006434 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 671143006435 thiS-thiF/thiG interaction site; other site 671143006436 enoyl-CoA hydratase; Provisional; Region: PRK06688 671143006437 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 671143006438 substrate binding site [chemical binding]; other site 671143006439 oxyanion hole (OAH) forming residues; other site 671143006440 trimer interface [polypeptide binding]; other site 671143006441 Uncharacterized conserved protein [Function unknown]; Region: COG1432 671143006442 NYN domain; Region: NYN; pfam01936 671143006443 putative metal binding site [ion binding]; other site 671143006444 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 671143006445 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 671143006446 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 671143006447 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 671143006448 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 671143006449 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 671143006450 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 671143006451 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 671143006452 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 671143006453 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 671143006454 active site 671143006455 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 671143006456 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 671143006457 GTP binding site; other site 671143006458 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 671143006459 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 671143006460 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 671143006461 catalytic site [active] 671143006462 G-X2-G-X-G-K; other site 671143006463 hypothetical protein; Provisional; Region: PRK04323 671143006464 hypothetical protein; Provisional; Region: PRK11820 671143006465 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 671143006466 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 671143006467 ATP-binding cassette domain of MutS homologs; Region: ABC_MutS_homologs; cd03243 671143006468 Walker A/P-loop; other site 671143006469 ATP binding site [chemical binding]; other site 671143006470 Q-loop/lid; other site 671143006471 ABC transporter signature motif; other site 671143006472 Walker B; other site 671143006473 D-loop; other site 671143006474 H-loop/switch region; other site 671143006475 Protein of unknown function (DUF497); Region: DUF497; cl01108 671143006476 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 671143006477 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 671143006478 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 671143006479 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 671143006480 putative active site [active] 671143006481 putative substrate binding site [chemical binding]; other site 671143006482 putative cosubstrate binding site; other site 671143006483 catalytic site [active] 671143006484 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 671143006485 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 671143006486 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 671143006487 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 671143006488 NAD binding site [chemical binding]; other site 671143006489 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 671143006490 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 671143006491 FAD binding pocket [chemical binding]; other site 671143006492 FAD binding motif [chemical binding]; other site 671143006493 phosphate binding motif [ion binding]; other site 671143006494 beta-alpha-beta structure motif; other site 671143006495 NAD binding pocket [chemical binding]; other site 671143006496 Iron coordination center [ion binding]; other site 671143006497 Methyltransferase domain; Region: Methyltransf_31; pfam13847 671143006498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143006499 S-adenosylmethionine binding site [chemical binding]; other site 671143006500 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 671143006501 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 671143006502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143006503 dimerization interface [polypeptide binding]; other site 671143006504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143006505 dimer interface [polypeptide binding]; other site 671143006506 phosphorylation site [posttranslational modification] 671143006507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143006508 ATP binding site [chemical binding]; other site 671143006509 Mg2+ binding site [ion binding]; other site 671143006510 G-X-G motif; other site 671143006511 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 671143006512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143006513 active site 671143006514 phosphorylation site [posttranslational modification] 671143006515 intermolecular recognition site; other site 671143006516 dimerization interface [polypeptide binding]; other site 671143006517 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143006518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143006519 active site 671143006520 phosphorylation site [posttranslational modification] 671143006521 intermolecular recognition site; other site 671143006522 dimerization interface [polypeptide binding]; other site 671143006523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143006524 Walker A motif; other site 671143006525 ATP binding site [chemical binding]; other site 671143006526 Walker B motif; other site 671143006527 arginine finger; other site 671143006528 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143006529 quinolinate synthetase; Provisional; Region: PRK09375 671143006530 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 671143006531 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 671143006532 dimerization interface [polypeptide binding]; other site 671143006533 active site 671143006534 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 671143006535 L-aspartate oxidase; Provisional; Region: PRK06175 671143006536 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 671143006537 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 671143006538 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 671143006539 putative NAD(P) binding site [chemical binding]; other site 671143006540 structural Zn binding site [ion binding]; other site 671143006541 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 671143006542 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 671143006543 active site 671143006544 catalytic site [active] 671143006545 metal binding site [ion binding]; metal-binding site 671143006546 dimer interface [polypeptide binding]; other site 671143006547 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 671143006548 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 671143006549 acyl-activating enzyme (AAE) consensus motif; other site 671143006550 putative AMP binding site [chemical binding]; other site 671143006551 putative active site [active] 671143006552 putative CoA binding site [chemical binding]; other site 671143006553 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 671143006554 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 671143006555 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 671143006556 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 671143006557 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 671143006558 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 671143006559 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 671143006560 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 671143006561 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 671143006562 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 671143006563 inhibitor-cofactor binding pocket; inhibition site 671143006564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143006565 catalytic residue [active] 671143006566 ATP-grasp domain; Region: ATP-grasp_4; cl17255 671143006567 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 671143006568 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 671143006569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 671143006570 motif II; other site 671143006571 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 671143006572 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 671143006573 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 671143006574 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 671143006575 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 671143006576 competence damage-inducible protein A; Provisional; Region: PRK00549 671143006577 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 671143006578 putative MPT binding site; other site 671143006579 Competence-damaged protein; Region: CinA; pfam02464 671143006580 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 671143006581 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 671143006582 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 671143006583 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 671143006584 metal binding site [ion binding]; metal-binding site 671143006585 active site 671143006586 I-site; other site 671143006587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 671143006588 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 671143006589 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 671143006590 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 671143006591 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 671143006592 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 671143006593 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 671143006594 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 671143006595 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 671143006596 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 671143006597 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 671143006598 Found in ATP-dependent protease La (LON); Region: LON; smart00464 671143006599 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 671143006600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143006601 Walker A motif; other site 671143006602 ATP binding site [chemical binding]; other site 671143006603 Walker B motif; other site 671143006604 arginine finger; other site 671143006605 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 671143006606 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 671143006607 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 671143006608 active site 671143006609 tetramer interface; other site 671143006610 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 671143006611 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 671143006612 ligand binding site [chemical binding]; other site 671143006613 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 671143006614 Permease; Region: Permease; pfam02405 671143006615 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 671143006616 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 671143006617 Walker A/P-loop; other site 671143006618 ATP binding site [chemical binding]; other site 671143006619 Q-loop/lid; other site 671143006620 ABC transporter signature motif; other site 671143006621 Walker B; other site 671143006622 D-loop; other site 671143006623 H-loop/switch region; other site 671143006624 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 671143006625 mce related protein; Region: MCE; pfam02470 671143006626 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 671143006627 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 671143006628 active site 671143006629 catalytic site [active] 671143006630 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 671143006631 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 671143006632 Domain of unknown function DUF21; Region: DUF21; pfam01595 671143006633 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 671143006634 Transporter associated domain; Region: CorC_HlyC; smart01091 671143006635 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 671143006636 guanine deaminase; Provisional; Region: PRK09228 671143006637 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 671143006638 active site 671143006639 Fic family protein [Function unknown]; Region: COG3177 671143006640 Fic/DOC family; Region: Fic; pfam02661 671143006641 HEAT repeats; Region: HEAT_2; pfam13646 671143006642 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 671143006643 dimer interface [polypeptide binding]; other site 671143006644 motif 1; other site 671143006645 active site 671143006646 motif 2; other site 671143006647 motif 3; other site 671143006648 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 671143006649 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 671143006650 active site 671143006651 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 671143006652 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 671143006653 aromatic arch; other site 671143006654 DCoH dimer interaction site [polypeptide binding]; other site 671143006655 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 671143006656 DCoH tetramer interaction site [polypeptide binding]; other site 671143006657 substrate binding site [chemical binding]; other site 671143006658 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 671143006659 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 671143006660 putative active site [active] 671143006661 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 671143006662 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 671143006663 TPP-binding site [chemical binding]; other site 671143006664 dimer interface [polypeptide binding]; other site 671143006665 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 671143006666 PYR/PP interface [polypeptide binding]; other site 671143006667 dimer interface [polypeptide binding]; other site 671143006668 TPP binding site [chemical binding]; other site 671143006669 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 671143006670 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 671143006671 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 671143006672 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 671143006673 phosphoribulokinase; Provisional; Region: PRK07429 671143006674 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 671143006675 active site 671143006676 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 671143006677 active site 671143006678 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 671143006679 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 671143006680 active site 671143006681 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821 671143006682 ATP-grasp domain; Region: ATP-grasp_3; pfam02655 671143006683 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 671143006684 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 671143006685 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 671143006686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 671143006687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143006688 S-adenosylmethionine binding site [chemical binding]; other site 671143006689 Transposase IS200 like; Region: Y1_Tnp; cl00848 671143006690 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 671143006691 DnaA box-binding interface [nucleotide binding]; other site 671143006692 Protein of unknown function DUF262; Region: DUF262; pfam03235 671143006693 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 671143006694 active site 671143006695 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 671143006696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143006697 non-specific DNA binding site [nucleotide binding]; other site 671143006698 salt bridge; other site 671143006699 sequence-specific DNA binding site [nucleotide binding]; other site 671143006700 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 671143006701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143006702 TPR motif; other site 671143006703 binding surface 671143006704 TPR repeat; Region: TPR_11; pfam13414 671143006705 TPR repeat; Region: TPR_11; pfam13414 671143006706 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 671143006707 substrate binding site [chemical binding]; other site 671143006708 nucleotide binding site [chemical binding]; other site 671143006709 hypothetical protein; Provisional; Region: PRK02227 671143006710 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 671143006711 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 671143006712 putative active site [active] 671143006713 Nuclease-related domain; Region: NERD; pfam08378 671143006714 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 671143006715 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 671143006716 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 671143006717 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 671143006718 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 671143006719 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 671143006720 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 671143006721 CoA binding domain; Region: CoA_binding; pfam02629 671143006722 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 671143006723 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 671143006724 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 671143006725 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 671143006726 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 671143006727 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 671143006728 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 671143006729 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 671143006730 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 671143006731 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 671143006732 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 671143006733 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 671143006734 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 671143006735 SLBB domain; Region: SLBB; pfam10531 671143006736 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 671143006737 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 671143006738 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 671143006739 [2Fe-2S] cluster binding site [ion binding]; other site 671143006740 putative dimer interface [polypeptide binding]; other site 671143006741 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 671143006742 NADH dehydrogenase subunit D; Validated; Region: PRK06075 671143006743 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 671143006744 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 671143006745 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 671143006746 ATP synthase subunit C; Region: ATP-synt_C; cl00466 671143006747 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 671143006748 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 671143006749 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 671143006750 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 671143006751 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 671143006752 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 671143006753 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 671143006754 hydrogenase 4 subunit D; Validated; Region: PRK06525 671143006755 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 671143006756 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 671143006757 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 671143006758 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 671143006759 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 671143006760 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 671143006761 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 671143006762 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 671143006763 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 671143006764 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 671143006765 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 671143006766 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 671143006767 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 671143006768 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 671143006769 inhibitor-cofactor binding pocket; inhibition site 671143006770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 671143006771 catalytic residue [active] 671143006772 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 671143006773 dimer interface [polypeptide binding]; other site 671143006774 active site 671143006775 Schiff base residues; other site 671143006776 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 671143006777 Organic solvent tolerance protein; Region: OstA_C; pfam04453 671143006778 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 671143006779 putative active site [active] 671143006780 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 671143006781 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 671143006782 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 671143006783 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 671143006784 putative active site [active] 671143006785 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 671143006786 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 671143006787 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 671143006788 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 671143006789 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 671143006790 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 671143006791 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 671143006792 CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113 671143006793 CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767 671143006794 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 671143006795 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 671143006796 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 671143006797 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 671143006798 ORF6N domain; Region: ORF6N; pfam10543 671143006799 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 671143006800 putative active site [active] 671143006801 Predicted transcriptional regulator [Transcription]; Region: COG2378 671143006802 HTH domain; Region: HTH_11; cl17392 671143006803 WYL domain; Region: WYL; pfam13280 671143006804 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 671143006805 putative active site [active] 671143006806 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 671143006807 hypothetical protein; Provisional; Region: PRK08609 671143006808 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 671143006809 active site 671143006810 primer binding site [nucleotide binding]; other site 671143006811 NTP binding site [chemical binding]; other site 671143006812 metal binding triad [ion binding]; metal-binding site 671143006813 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 671143006814 active site 671143006815 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 671143006816 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 671143006817 Protein of unknown function (DUF721); Region: DUF721; pfam05258 671143006818 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 671143006819 RNA/DNA hybrid binding site [nucleotide binding]; other site 671143006820 active site 671143006821 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 671143006822 Putative zinc ribbon domain; Region: DUF164; pfam02591 671143006823 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 671143006824 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 671143006825 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 671143006826 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 671143006827 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 671143006828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 671143006829 DNA binding residues [nucleotide binding] 671143006830 DNA primase; Validated; Region: dnaG; PRK05667 671143006831 CHC2 zinc finger; Region: zf-CHC2; pfam01807 671143006832 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 671143006833 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 671143006834 active site 671143006835 metal binding site [ion binding]; metal-binding site 671143006836 interdomain interaction site; other site 671143006837 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 671143006838 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 671143006839 MutS domain III; Region: MutS_III; pfam05192 671143006840 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 671143006841 Walker A/P-loop; other site 671143006842 ATP binding site [chemical binding]; other site 671143006843 Q-loop/lid; other site 671143006844 ABC transporter signature motif; other site 671143006845 Walker B; other site 671143006846 D-loop; other site 671143006847 H-loop/switch region; other site 671143006848 Smr domain; Region: Smr; pfam01713 671143006849 Yqey-like protein; Region: YqeY; cl17540 671143006850 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 671143006851 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 671143006852 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 671143006853 active site 671143006854 Peptidase family M48; Region: Peptidase_M48; cl12018 671143006855 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 671143006856 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 671143006857 DNA binding residues [nucleotide binding] 671143006858 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 671143006859 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 671143006860 HSP70 interaction site [polypeptide binding]; other site 671143006861 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 671143006862 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 671143006863 dimer interface [polypeptide binding]; other site 671143006864 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 671143006865 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 671143006866 putative dimer interface [polypeptide binding]; other site 671143006867 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 671143006868 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 671143006869 nucleotide binding site [chemical binding]; other site 671143006870 NEF interaction site [polypeptide binding]; other site 671143006871 SBD interface [polypeptide binding]; other site 671143006872 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 671143006873 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 671143006874 N-acetyl-D-glucosamine binding site [chemical binding]; other site 671143006875 catalytic residue [active] 671143006876 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 671143006877 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 671143006878 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 671143006879 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 671143006880 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 671143006881 Multicopper oxidase; Region: Cu-oxidase; pfam00394 671143006882 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 671143006883 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 671143006884 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 671143006885 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 671143006886 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 671143006887 substrate binding site; other site 671143006888 metal-binding site 671143006889 Oligomer interface; other site 671143006890 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 671143006891 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 671143006892 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 671143006893 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 671143006894 NAD binding site [chemical binding]; other site 671143006895 substrate binding site [chemical binding]; other site 671143006896 homodimer interface [polypeptide binding]; other site 671143006897 active site 671143006898 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 671143006899 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 671143006900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 671143006901 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 671143006902 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 671143006903 NAD binding site [chemical binding]; other site 671143006904 putative substrate binding site 2 [chemical binding]; other site 671143006905 putative substrate binding site 1 [chemical binding]; other site 671143006906 active site 671143006907 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 671143006908 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 671143006909 homodimer interface [polypeptide binding]; other site 671143006910 substrate-cofactor binding pocket; other site 671143006911 catalytic residue [active] 671143006912 Cytochrome c; Region: Cytochrom_C; pfam00034 671143006913 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 671143006914 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 671143006915 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 671143006916 Ligand Binding Site [chemical binding]; other site 671143006917 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 671143006918 FMN binding site [chemical binding]; other site 671143006919 substrate binding site [chemical binding]; other site 671143006920 putative catalytic residue [active] 671143006921 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 671143006922 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 671143006923 catalytic triad [active] 671143006924 Smr domain; Region: Smr; pfam01713 671143006925 Predicted permease; Region: DUF318; cl17795 671143006926 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143006927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143006928 active site 671143006929 phosphorylation site [posttranslational modification] 671143006930 intermolecular recognition site; other site 671143006931 dimerization interface [polypeptide binding]; other site 671143006932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143006933 Walker A motif; other site 671143006934 ATP binding site [chemical binding]; other site 671143006935 Walker B motif; other site 671143006936 arginine finger; other site 671143006937 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143006938 CHASE3 domain; Region: CHASE3; cl05000 671143006939 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 671143006940 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143006941 dimerization interface [polypeptide binding]; other site 671143006942 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143006943 dimer interface [polypeptide binding]; other site 671143006944 phosphorylation site [posttranslational modification] 671143006945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143006946 ATP binding site [chemical binding]; other site 671143006947 Mg2+ binding site [ion binding]; other site 671143006948 G-X-G motif; other site 671143006949 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 671143006950 4Fe-4S binding domain; Region: Fer4; pfam00037 671143006951 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 671143006952 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 671143006953 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 671143006954 Ubiquitin-like proteins; Region: UBQ; cl00155 671143006955 charged pocket; other site 671143006956 hydrophobic patch; other site 671143006957 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 671143006958 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 671143006959 MOSC domain; Region: MOSC; pfam03473 671143006960 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 671143006961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 671143006962 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 671143006963 MoaE interaction surface [polypeptide binding]; other site 671143006964 MoeB interaction surface [polypeptide binding]; other site 671143006965 thiocarboxylated glycine; other site 671143006966 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 671143006967 active site 671143006968 Ap4A binding cleft/pocket [chemical binding]; other site 671143006969 P4 phosphate binding site; other site 671143006970 nudix motif; other site 671143006971 putative P2/P3 phosphate binding site [ion binding]; other site 671143006972 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 671143006973 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 671143006974 substrate binding site [chemical binding]; other site 671143006975 dimer interface [polypeptide binding]; other site 671143006976 ATP binding site [chemical binding]; other site 671143006977 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 671143006978 active site 671143006979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 671143006980 Peptidase M15; Region: Peptidase_M15_3; cl01194 671143006981 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 671143006982 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 671143006983 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 671143006984 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 671143006985 Citrate synthase; Region: Citrate_synt; pfam00285 671143006986 oxalacetate binding site [chemical binding]; other site 671143006987 citrylCoA binding site [chemical binding]; other site 671143006988 coenzyme A binding site [chemical binding]; other site 671143006989 catalytic triad [active] 671143006990 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 671143006991 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 671143006992 active site 671143006993 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 671143006994 active site 671143006995 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 671143006996 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 671143006997 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 671143006998 ABC transporter; Region: ABC_tran_2; pfam12848 671143006999 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 671143007000 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143007001 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143007002 dimerization interface [polypeptide binding]; other site 671143007003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143007004 dimer interface [polypeptide binding]; other site 671143007005 phosphorylation site [posttranslational modification] 671143007006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143007007 ATP binding site [chemical binding]; other site 671143007008 Mg2+ binding site [ion binding]; other site 671143007009 G-X-G motif; other site 671143007010 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 671143007011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143007012 active site 671143007013 phosphorylation site [posttranslational modification] 671143007014 intermolecular recognition site; other site 671143007015 dimerization interface [polypeptide binding]; other site 671143007016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 671143007017 DNA binding site [nucleotide binding] 671143007018 FOG: WD40 repeat [General function prediction only]; Region: COG2319 671143007019 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 671143007020 structural tetrad; other site 671143007021 Protein of unknown function DUF72; Region: DUF72; cl00777 671143007022 epoxyqueuosine reductase; Region: TIGR00276 671143007023 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 671143007024 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 671143007025 protein binding surface [polypeptide binding]; other site 671143007026 HEAT repeats; Region: HEAT_2; pfam13646 671143007027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143007028 Methyltransferase domain; Region: Methyltransf_31; pfam13847 671143007029 S-adenosylmethionine binding site [chemical binding]; other site 671143007030 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 671143007031 dimerization interface [polypeptide binding]; other site 671143007032 putative DNA binding site [nucleotide binding]; other site 671143007033 putative Zn2+ binding site [ion binding]; other site 671143007034 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 671143007035 hydrogenase 4 subunit B; Validated; Region: PRK06521 671143007036 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 671143007037 NADH dehydrogenase; Region: NADHdh; cl00469 671143007038 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 671143007039 hydrogenase 4 subunit F; Validated; Region: PRK06458 671143007040 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 671143007041 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 671143007042 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 671143007043 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 671143007044 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 671143007045 active site 671143007046 dimer interface [polypeptide binding]; other site 671143007047 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 671143007048 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 671143007049 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 671143007050 DNA methylase; Region: N6_N4_Mtase; pfam01555 671143007051 DNA methylase; Region: N6_N4_Mtase; cl17433 671143007052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 671143007053 AAA domain; Region: AAA_23; pfam13476 671143007054 Walker A/P-loop; other site 671143007055 ATP binding site [chemical binding]; other site 671143007056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 671143007057 AAA domain; Region: AAA_21; pfam13304 671143007058 Q-loop/lid; other site 671143007059 ABC transporter signature motif; other site 671143007060 Walker B; other site 671143007061 D-loop; other site 671143007062 H-loop/switch region; other site 671143007063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143007064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143007065 dimerization interface [polypeptide binding]; other site 671143007066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143007067 dimer interface [polypeptide binding]; other site 671143007068 phosphorylation site [posttranslational modification] 671143007069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143007070 ATP binding site [chemical binding]; other site 671143007071 Mg2+ binding site [ion binding]; other site 671143007072 G-X-G motif; other site 671143007073 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143007074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143007075 active site 671143007076 phosphorylation site [posttranslational modification] 671143007077 intermolecular recognition site; other site 671143007078 dimerization interface [polypeptide binding]; other site 671143007079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143007080 Walker A motif; other site 671143007081 ATP binding site [chemical binding]; other site 671143007082 Walker B motif; other site 671143007083 arginine finger; other site 671143007084 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143007085 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 671143007086 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 671143007087 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 671143007088 DNA binding residues [nucleotide binding] 671143007089 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 671143007090 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 671143007091 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 671143007092 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 671143007093 active site 671143007094 NTP binding site [chemical binding]; other site 671143007095 metal binding triad [ion binding]; metal-binding site 671143007096 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 671143007097 Peptidase family M50; Region: Peptidase_M50; pfam02163 671143007098 active site 671143007099 putative substrate binding region [chemical binding]; other site 671143007100 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 671143007101 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 671143007102 active site 671143007103 HIGH motif; other site 671143007104 dimer interface [polypeptide binding]; other site 671143007105 KMSKS motif; other site 671143007106 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 671143007107 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 671143007108 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 671143007109 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 671143007110 active site 671143007111 GMP synthase; Reviewed; Region: guaA; PRK00074 671143007112 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 671143007113 AMP/PPi binding site [chemical binding]; other site 671143007114 candidate oxyanion hole; other site 671143007115 catalytic triad [active] 671143007116 potential glutamine specificity residues [chemical binding]; other site 671143007117 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 671143007118 ATP Binding subdomain [chemical binding]; other site 671143007119 Ligand Binding sites [chemical binding]; other site 671143007120 Dimerization subdomain; other site 671143007121 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 671143007122 active site 671143007123 NTP binding site [chemical binding]; other site 671143007124 metal binding triad [ion binding]; metal-binding site 671143007125 Uncharacterized conserved protein [Function unknown]; Region: COG2361 671143007126 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 671143007127 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 671143007128 active site 671143007129 PHP Thumb interface [polypeptide binding]; other site 671143007130 metal binding site [ion binding]; metal-binding site 671143007131 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 671143007132 generic binding surface II; other site 671143007133 generic binding surface I; other site 671143007134 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 671143007135 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 671143007136 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 671143007137 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 671143007138 protease TldD; Provisional; Region: tldD; PRK10735 671143007139 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 671143007140 endonuclease III; Region: ENDO3c; smart00478 671143007141 minor groove reading motif; other site 671143007142 helix-hairpin-helix signature motif; other site 671143007143 substrate binding pocket [chemical binding]; other site 671143007144 active site 671143007145 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 671143007146 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 671143007147 active site 671143007148 8-oxo-dGMP binding site [chemical binding]; other site 671143007149 nudix motif; other site 671143007150 metal binding site [ion binding]; metal-binding site 671143007151 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 671143007152 active site 671143007153 catalytic residues [active] 671143007154 metal binding site [ion binding]; metal-binding site 671143007155 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 671143007156 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 671143007157 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 671143007158 DGQHR domain; Region: DGQHR; TIGR03187 671143007159 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 671143007160 FOG: WD40 repeat [General function prediction only]; Region: COG2319 671143007161 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 671143007162 structural tetrad; other site 671143007163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143007164 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143007165 dimerization interface [polypeptide binding]; other site 671143007166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143007167 dimer interface [polypeptide binding]; other site 671143007168 phosphorylation site [posttranslational modification] 671143007169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143007170 ATP binding site [chemical binding]; other site 671143007171 Mg2+ binding site [ion binding]; other site 671143007172 G-X-G motif; other site 671143007173 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 671143007174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143007175 active site 671143007176 phosphorylation site [posttranslational modification] 671143007177 intermolecular recognition site; other site 671143007178 dimerization interface [polypeptide binding]; other site 671143007179 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 671143007180 DNA binding site [nucleotide binding] 671143007181 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 671143007182 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143007183 sequence-specific DNA binding site [nucleotide binding]; other site 671143007184 salt bridge; other site 671143007185 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 671143007186 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 671143007187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143007188 TPR repeat; Region: TPR_11; pfam13414 671143007189 TPR motif; other site 671143007190 binding surface 671143007191 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 671143007192 binding surface 671143007193 TPR repeat; Region: TPR_11; pfam13414 671143007194 TPR motif; other site 671143007195 TPR repeat; Region: TPR_11; pfam13414 671143007196 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 671143007197 Mechanosensitive ion channel; Region: MS_channel; pfam00924 671143007198 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 671143007199 active site 671143007200 catalytic site [active] 671143007201 homodimer interface [polypeptide binding]; other site 671143007202 Lid 1; other site 671143007203 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 671143007204 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 671143007205 glycogen branching enzyme; Provisional; Region: PRK05402 671143007206 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 671143007207 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 671143007208 active site 671143007209 catalytic site [active] 671143007210 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 671143007211 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 671143007212 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 671143007213 Transglycosylase; Region: Transgly; pfam00912 671143007214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 671143007215 Protein of unknown function (DUF497); Region: DUF497; cl01108 671143007216 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 671143007217 Part of AAA domain; Region: AAA_19; pfam13245 671143007218 Family description; Region: UvrD_C_2; pfam13538 671143007219 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 671143007220 Uncharacterized conserved protein [Function unknown]; Region: COG5663 671143007221 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 671143007222 Helix-turn-helix domain; Region: HTH_25; pfam13413 671143007223 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 671143007224 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 671143007225 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 671143007226 FMN-binding domain; Region: FMN_bind; pfam04205 671143007227 prefoldin subunit beta; Provisional; Region: PRK09343 671143007228 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 671143007229 ApbE family; Region: ApbE; pfam02424 671143007230 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 671143007231 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 671143007232 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 671143007233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 671143007234 Walker A/P-loop; other site 671143007235 ATP binding site [chemical binding]; other site 671143007236 Q-loop/lid; other site 671143007237 ABC transporter signature motif; other site 671143007238 Walker B; other site 671143007239 D-loop; other site 671143007240 H-loop/switch region; other site 671143007241 TOBE domain; Region: TOBE_2; pfam08402 671143007242 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 671143007243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 671143007244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 671143007245 dimer interface [polypeptide binding]; other site 671143007246 conserved gate region; other site 671143007247 putative PBP binding loops; other site 671143007248 ABC-ATPase subunit interface; other site 671143007249 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 671143007250 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 671143007251 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 671143007252 dinuclear metal binding motif [ion binding]; other site 671143007253 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 671143007254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 671143007255 Coenzyme A binding pocket [chemical binding]; other site 671143007256 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 671143007257 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 671143007258 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 671143007259 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 671143007260 catalytic residues [active] 671143007261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 671143007262 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 671143007263 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 671143007264 active site 671143007265 catalytic tetrad [active] 671143007266 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 671143007267 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 671143007268 acylphosphatase; Provisional; Region: PRK14423 671143007269 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 671143007270 active site lid residues [active] 671143007271 substrate binding pocket [chemical binding]; other site 671143007272 catalytic residues [active] 671143007273 substrate-Mg2+ binding site; other site 671143007274 aspartate-rich region 1; other site 671143007275 aspartate-rich region 2; other site 671143007276 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 671143007277 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 671143007278 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 671143007279 Cupin domain; Region: Cupin_2; cl17218 671143007280 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 671143007281 intersubunit interface [polypeptide binding]; other site 671143007282 active site 671143007283 Zn2+ binding site [ion binding]; other site 671143007284 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 671143007285 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 671143007286 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 671143007287 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 671143007288 dimer interface [polypeptide binding]; other site 671143007289 catalytic residue [active] 671143007290 metal binding site [ion binding]; metal-binding site 671143007291 Protein of unknown function (DUF497); Region: DUF497; pfam04365 671143007292 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 671143007293 active site 671143007294 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 671143007295 catalytic tetrad [active] 671143007296 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 671143007297 putative active site [active] 671143007298 putative metal binding residues [ion binding]; other site 671143007299 signature motif; other site 671143007300 putative triphosphate binding site [ion binding]; other site 671143007301 dimer interface [polypeptide binding]; other site 671143007302 PAS domain S-box; Region: sensory_box; TIGR00229 671143007303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143007304 putative active site [active] 671143007305 heme pocket [chemical binding]; other site 671143007306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143007307 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 671143007308 putative active site [active] 671143007309 heme pocket [chemical binding]; other site 671143007310 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 671143007311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143007312 putative active site [active] 671143007313 heme pocket [chemical binding]; other site 671143007314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143007315 dimer interface [polypeptide binding]; other site 671143007316 phosphorylation site [posttranslational modification] 671143007317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143007318 ATP binding site [chemical binding]; other site 671143007319 Mg2+ binding site [ion binding]; other site 671143007320 G-X-G motif; other site 671143007321 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 671143007322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143007323 active site 671143007324 phosphorylation site [posttranslational modification] 671143007325 intermolecular recognition site; other site 671143007326 dimerization interface [polypeptide binding]; other site 671143007327 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 671143007328 active site 671143007329 substrate-binding site [chemical binding]; other site 671143007330 metal-binding site [ion binding] 671143007331 GTP binding site [chemical binding]; other site 671143007332 recombination protein RecR; Reviewed; Region: recR; PRK00076 671143007333 RecR protein; Region: RecR; pfam02132 671143007334 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 671143007335 putative active site [active] 671143007336 putative metal-binding site [ion binding]; other site 671143007337 tetramer interface [polypeptide binding]; other site 671143007338 hypothetical protein; Validated; Region: PRK00153 671143007339 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 671143007340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143007341 Walker A motif; other site 671143007342 ATP binding site [chemical binding]; other site 671143007343 Walker B motif; other site 671143007344 arginine finger; other site 671143007345 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 671143007346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 671143007347 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 671143007348 NAD(P) binding site [chemical binding]; other site 671143007349 active site 671143007350 seryl-tRNA synthetase; Provisional; Region: PRK05431 671143007351 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 671143007352 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 671143007353 dimer interface [polypeptide binding]; other site 671143007354 active site 671143007355 motif 1; other site 671143007356 motif 2; other site 671143007357 motif 3; other site 671143007358 DNA gyrase subunit A; Validated; Region: PRK05560 671143007359 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 671143007360 CAP-like domain; other site 671143007361 active site 671143007362 primary dimer interface [polypeptide binding]; other site 671143007363 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 671143007364 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 671143007365 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 671143007366 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 671143007367 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 671143007368 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 671143007369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143007370 Mg2+ binding site [ion binding]; other site 671143007371 G-X-G motif; other site 671143007372 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 671143007373 anchoring element; other site 671143007374 dimer interface [polypeptide binding]; other site 671143007375 ATP binding site [chemical binding]; other site 671143007376 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 671143007377 active site 671143007378 putative metal-binding site [ion binding]; other site 671143007379 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 671143007380 DNA polymerase III subunit beta; Validated; Region: PRK05643 671143007381 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 671143007382 putative DNA binding surface [nucleotide binding]; other site 671143007383 dimer interface [polypeptide binding]; other site 671143007384 beta-clamp/clamp loader binding surface; other site 671143007385 beta-clamp/translesion DNA polymerase binding surface; other site 671143007386 Ribonuclease P; Region: Ribonuclease_P; pfam00825 671143007387 Haemolytic domain; Region: Haemolytic; pfam01809 671143007388 membrane protein insertase; Provisional; Region: PRK01318 671143007389 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 671143007390 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 671143007391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143007392 S-adenosylmethionine binding site [chemical binding]; other site 671143007393 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 671143007394 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 671143007395 P-loop; other site 671143007396 Magnesium ion binding site [ion binding]; other site 671143007397 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 671143007398 Magnesium ion binding site [ion binding]; other site 671143007399 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 671143007400 ParB-like nuclease domain; Region: ParB; smart00470 671143007401 KorB domain; Region: KorB; pfam08535 671143007402 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 671143007403 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 671143007404 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 671143007405 catalytic residue [active] 671143007406 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 671143007407 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 671143007408 Ligand Binding Site [chemical binding]; other site 671143007409 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 671143007410 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 671143007411 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 671143007412 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 671143007413 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 671143007414 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 671143007415 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 671143007416 beta subunit interaction interface [polypeptide binding]; other site 671143007417 Walker A motif; other site 671143007418 ATP binding site [chemical binding]; other site 671143007419 Walker B motif; other site 671143007420 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 671143007421 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 671143007422 core domain interface [polypeptide binding]; other site 671143007423 delta subunit interface [polypeptide binding]; other site 671143007424 epsilon subunit interface [polypeptide binding]; other site 671143007425 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 671143007426 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 671143007427 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 671143007428 alpha subunit interaction interface [polypeptide binding]; other site 671143007429 Walker A motif; other site 671143007430 ATP binding site [chemical binding]; other site 671143007431 Walker B motif; other site 671143007432 inhibitor binding site; inhibition site 671143007433 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 671143007434 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 671143007435 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 671143007436 gamma subunit interface [polypeptide binding]; other site 671143007437 epsilon subunit interface [polypeptide binding]; other site 671143007438 LBP interface [polypeptide binding]; other site 671143007439 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 671143007440 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 671143007441 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 671143007442 homotrimer interaction site [polypeptide binding]; other site 671143007443 putative active site [active] 671143007444 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 671143007445 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 671143007446 GIY-YIG motif/motif A; other site 671143007447 active site 671143007448 catalytic site [active] 671143007449 putative DNA binding site [nucleotide binding]; other site 671143007450 metal binding site [ion binding]; metal-binding site 671143007451 UvrB/uvrC motif; Region: UVR; pfam02151 671143007452 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 671143007453 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 671143007454 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 671143007455 G1 box; other site 671143007456 putative GEF interaction site [polypeptide binding]; other site 671143007457 GTP/Mg2+ binding site [chemical binding]; other site 671143007458 Switch I region; other site 671143007459 G2 box; other site 671143007460 G3 box; other site 671143007461 Switch II region; other site 671143007462 G4 box; other site 671143007463 G5 box; other site 671143007464 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 671143007465 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 671143007466 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 671143007467 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 671143007468 homoserine kinase; Provisional; Region: PRK01212 671143007469 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 671143007470 pyrroline-5-carboxylate reductase; Region: PLN02688 671143007471 YGGT family; Region: YGGT; pfam02325 671143007472 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 671143007473 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 671143007474 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 671143007475 active site 671143007476 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 671143007477 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 671143007478 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 671143007479 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 671143007480 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 671143007481 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 671143007482 putative active site [active] 671143007483 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 671143007484 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 671143007485 dimer interface [polypeptide binding]; other site 671143007486 motif 1; other site 671143007487 active site 671143007488 motif 2; other site 671143007489 motif 3; other site 671143007490 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 671143007491 anticodon binding site; other site 671143007492 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 671143007493 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 671143007494 dimer interface [polypeptide binding]; other site 671143007495 anticodon binding site; other site 671143007496 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 671143007497 homodimer interface [polypeptide binding]; other site 671143007498 motif 1; other site 671143007499 active site 671143007500 motif 2; other site 671143007501 GAD domain; Region: GAD; pfam02938 671143007502 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 671143007503 motif 3; other site 671143007504 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 671143007505 PhoH-like protein; Region: PhoH; pfam02562 671143007506 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 671143007507 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 671143007508 Zn2+ binding site [ion binding]; other site 671143007509 Mg2+ binding site [ion binding]; other site 671143007510 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 671143007511 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 671143007512 GTPase Era; Reviewed; Region: era; PRK00089 671143007513 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 671143007514 G1 box; other site 671143007515 GTP/Mg2+ binding site [chemical binding]; other site 671143007516 Switch I region; other site 671143007517 G2 box; other site 671143007518 Switch II region; other site 671143007519 G3 box; other site 671143007520 G4 box; other site 671143007521 G5 box; other site 671143007522 KH domain; Region: KH_2; pfam07650 671143007523 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 671143007524 Recombination protein O N terminal; Region: RecO_N; pfam11967 671143007525 Recombination protein O C terminal; Region: RecO_C; pfam02565 671143007526 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 671143007527 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 671143007528 putative NAD(P) binding site [chemical binding]; other site 671143007529 putative substrate binding site [chemical binding]; other site 671143007530 catalytic Zn binding site [ion binding]; other site 671143007531 structural Zn binding site [ion binding]; other site 671143007532 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143007533 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 671143007534 FeS/SAM binding site; other site 671143007535 Tim44-like domain; Region: Tim44; pfam04280 671143007536 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 671143007537 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 671143007538 active site 671143007539 Int/Topo IB signature motif; other site 671143007540 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 671143007541 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 671143007542 putative ADP-binding pocket [chemical binding]; other site 671143007543 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 671143007544 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 671143007545 active site 671143007546 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 671143007547 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 671143007548 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 671143007549 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 671143007550 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 671143007551 Type II transport protein GspH; Region: GspH; pfam12019 671143007552 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 671143007553 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 671143007554 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143007555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143007556 active site 671143007557 phosphorylation site [posttranslational modification] 671143007558 intermolecular recognition site; other site 671143007559 dimerization interface [polypeptide binding]; other site 671143007560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143007561 Walker A motif; other site 671143007562 ATP binding site [chemical binding]; other site 671143007563 Walker B motif; other site 671143007564 arginine finger; other site 671143007565 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143007566 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 671143007567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143007568 putative active site [active] 671143007569 heme pocket [chemical binding]; other site 671143007570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143007571 phosphorylation site [posttranslational modification] 671143007572 dimer interface [polypeptide binding]; other site 671143007573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143007574 ATP binding site [chemical binding]; other site 671143007575 Mg2+ binding site [ion binding]; other site 671143007576 G-X-G motif; other site 671143007577 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 671143007578 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 671143007579 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 671143007580 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 671143007581 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 671143007582 Walker A motif; other site 671143007583 ATP binding site [chemical binding]; other site 671143007584 Walker B motif; other site 671143007585 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 671143007586 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 671143007587 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 671143007588 Walker A motif; other site 671143007589 ATP binding site [chemical binding]; other site 671143007590 Walker B motif; other site 671143007591 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 671143007592 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 671143007593 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 671143007594 shikimate binding site; other site 671143007595 NAD(P) binding site [chemical binding]; other site 671143007596 PII uridylyl-transferase; Provisional; Region: PRK05092 671143007597 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 671143007598 metal binding triad; other site 671143007599 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 671143007600 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 671143007601 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 671143007602 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 671143007603 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 671143007604 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 671143007605 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 671143007606 Nitrate and nitrite sensing; Region: NIT; pfam08376 671143007607 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143007608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143007609 dimer interface [polypeptide binding]; other site 671143007610 phosphorylation site [posttranslational modification] 671143007611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143007612 ATP binding site [chemical binding]; other site 671143007613 Mg2+ binding site [ion binding]; other site 671143007614 G-X-G motif; other site 671143007615 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 671143007616 HSP70 interaction site [polypeptide binding]; other site 671143007617 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 671143007618 substrate binding site [polypeptide binding]; other site 671143007619 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 671143007620 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 671143007621 putative active site [active] 671143007622 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 671143007623 nudix motif; other site 671143007624 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 671143007625 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 671143007626 Uncharacterized conserved protein [Function unknown]; Region: COG0432 671143007627 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 671143007628 putative active site [active] 671143007629 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 671143007630 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 671143007631 Ligand binding site; other site 671143007632 oligomer interface; other site 671143007633 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 671143007634 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 671143007635 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 671143007636 active site 671143007637 purine riboside binding site [chemical binding]; other site 671143007638 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 671143007639 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 671143007640 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 671143007641 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 671143007642 active site 671143007643 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 671143007644 CoA-transferase family III; Region: CoA_transf_3; pfam02515 671143007645 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 671143007646 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 671143007647 Cysteine-rich domain; Region: CCG; pfam02754 671143007648 Cysteine-rich domain; Region: CCG; pfam02754 671143007649 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 671143007650 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 671143007651 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 671143007652 active site 671143007653 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 671143007654 substrate binding site [chemical binding]; other site 671143007655 active site 671143007656 ferrochelatase; Reviewed; Region: hemH; PRK00035 671143007657 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 671143007658 C-terminal domain interface [polypeptide binding]; other site 671143007659 active site 671143007660 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 671143007661 active site 671143007662 N-terminal domain interface [polypeptide binding]; other site 671143007663 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 671143007664 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 671143007665 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 671143007666 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 671143007667 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 671143007668 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 671143007669 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 671143007670 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 671143007671 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 671143007672 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 671143007673 Restriction endonuclease XhoI; Region: XhoI; pfam04555 671143007674 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 671143007675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143007676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143007677 S-adenosylmethionine binding site [chemical binding]; other site 671143007678 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 671143007679 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 671143007680 Sodium Bile acid symporter family; Region: SBF; cl17470 671143007681 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 671143007682 active site 671143007683 NTP binding site [chemical binding]; other site 671143007684 metal binding triad [ion binding]; metal-binding site 671143007685 antibiotic binding site [chemical binding]; other site 671143007686 Protein of unknown function DUF86; Region: DUF86; cl01031 671143007687 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 671143007688 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 671143007689 FtsX-like permease family; Region: FtsX; pfam02687 671143007690 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 671143007691 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 671143007692 Walker A/P-loop; other site 671143007693 ATP binding site [chemical binding]; other site 671143007694 Q-loop/lid; other site 671143007695 ABC transporter signature motif; other site 671143007696 Walker B; other site 671143007697 D-loop; other site 671143007698 H-loop/switch region; other site 671143007699 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 671143007700 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 671143007701 ligand binding site [chemical binding]; other site 671143007702 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 671143007703 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 671143007704 transmembrane helices; other site 671143007705 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 671143007706 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 671143007707 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 671143007708 active site 671143007709 metal binding site [ion binding]; metal-binding site 671143007710 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 671143007711 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 671143007712 Predicted permeases [General function prediction only]; Region: COG0795 671143007713 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 671143007714 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 671143007715 active site 671143007716 metal-binding site 671143007717 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 671143007718 acyl-CoA synthetase; Validated; Region: PRK09192 671143007719 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 671143007720 acyl-activating enzyme (AAE) consensus motif; other site 671143007721 active site 671143007722 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 671143007723 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 671143007724 putative NAD(P) binding site [chemical binding]; other site 671143007725 active site 671143007726 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 671143007727 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 671143007728 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 671143007729 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 671143007730 catalytic residue [active] 671143007731 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 671143007732 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 671143007733 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 671143007734 Walker A/P-loop; other site 671143007735 ATP binding site [chemical binding]; other site 671143007736 Q-loop/lid; other site 671143007737 ABC transporter signature motif; other site 671143007738 Walker B; other site 671143007739 D-loop; other site 671143007740 H-loop/switch region; other site 671143007741 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 671143007742 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 671143007743 Fatty acid desaturase; Region: FA_desaturase; pfam00487 671143007744 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 671143007745 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 671143007746 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 671143007747 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 671143007748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143007749 Walker A motif; other site 671143007750 ATP binding site [chemical binding]; other site 671143007751 Walker B motif; other site 671143007752 arginine finger; other site 671143007753 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 671143007754 hypothetical protein; Reviewed; Region: PRK12497 671143007755 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 671143007756 RNA/DNA hybrid binding site [nucleotide binding]; other site 671143007757 active site 671143007758 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 671143007759 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 671143007760 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 671143007761 RimM N-terminal domain; Region: RimM; pfam01782 671143007762 PRC-barrel domain; Region: PRC; pfam05239 671143007763 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 671143007764 KH domain; Region: KH_4; pfam13083 671143007765 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 671143007766 signal recognition particle protein; Provisional; Region: PRK10867 671143007767 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 671143007768 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 671143007769 P loop; other site 671143007770 GTP binding site [chemical binding]; other site 671143007771 Signal peptide binding domain; Region: SRP_SPB; pfam02978 671143007772 RDD family; Region: RDD; pfam06271 671143007773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 671143007774 non-specific DNA binding site [nucleotide binding]; other site 671143007775 salt bridge; other site 671143007776 sequence-specific DNA binding site [nucleotide binding]; other site 671143007777 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 671143007778 Peptidase M60-like family; Region: M60-like; pfam13402 671143007779 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 671143007780 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 671143007781 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 671143007782 catalytic residue [active] 671143007783 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 671143007784 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 671143007785 ligand binding site [chemical binding]; other site 671143007786 NAD binding site [chemical binding]; other site 671143007787 dimerization interface [polypeptide binding]; other site 671143007788 catalytic site [active] 671143007789 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 671143007790 putative L-serine binding site [chemical binding]; other site 671143007791 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 671143007792 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 671143007793 dimer interface [polypeptide binding]; other site 671143007794 motif 1; other site 671143007795 active site 671143007796 motif 2; other site 671143007797 motif 3; other site 671143007798 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 671143007799 anticodon binding site; other site 671143007800 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 671143007801 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 671143007802 GDP-binding site [chemical binding]; other site 671143007803 ACT binding site; other site 671143007804 IMP binding site; other site 671143007805 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 671143007806 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 671143007807 FMN binding site [chemical binding]; other site 671143007808 active site 671143007809 catalytic residues [active] 671143007810 substrate binding site [chemical binding]; other site 671143007811 Putative Ig domain; Region: He_PIG; pfam05345 671143007812 FRG domain; Region: FRG; pfam08867 671143007813 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143007814 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143007815 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 671143007816 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 671143007817 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 671143007818 Ligand Binding Site [chemical binding]; other site 671143007819 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 671143007820 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 671143007821 FeS/SAM binding site; other site 671143007822 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 671143007823 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 671143007824 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 671143007825 protein binding site [polypeptide binding]; other site 671143007826 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 671143007827 protein binding site [polypeptide binding]; other site 671143007828 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 671143007829 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 671143007830 Methyltransferase domain; Region: Methyltransf_23; pfam13489 671143007831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143007832 S-adenosylmethionine binding site [chemical binding]; other site 671143007833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 671143007834 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 671143007835 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 671143007836 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 671143007837 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 671143007838 Putative addiction module component; Region: Unstab_antitox; pfam09720 671143007839 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 671143007840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143007841 active site 671143007842 phosphorylation site [posttranslational modification] 671143007843 intermolecular recognition site; other site 671143007844 dimerization interface [polypeptide binding]; other site 671143007845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 671143007846 Walker A motif; other site 671143007847 ATP binding site [chemical binding]; other site 671143007848 Walker B motif; other site 671143007849 arginine finger; other site 671143007850 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 671143007851 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 671143007852 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 671143007853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 671143007854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143007855 phosphorylation site [posttranslational modification] 671143007856 dimer interface [polypeptide binding]; other site 671143007857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143007858 ATP binding site [chemical binding]; other site 671143007859 Mg2+ binding site [ion binding]; other site 671143007860 G-X-G motif; other site 671143007861 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 671143007862 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 671143007863 dimer interface [polypeptide binding]; other site 671143007864 ADP-ribose binding site [chemical binding]; other site 671143007865 active site 671143007866 nudix motif; other site 671143007867 metal binding site [ion binding]; metal-binding site 671143007868 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 671143007869 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 671143007870 phosphodiesterase YaeI; Provisional; Region: PRK11340 671143007871 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 671143007872 putative active site [active] 671143007873 putative metal binding site [ion binding]; other site 671143007874 SurA N-terminal domain; Region: SurA_N_3; cl07813 671143007875 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 671143007876 rod shape-determining protein MreB; Provisional; Region: PRK13927 671143007877 MreB and similar proteins; Region: MreB_like; cd10225 671143007878 nucleotide binding site [chemical binding]; other site 671143007879 Mg binding site [ion binding]; other site 671143007880 putative protofilament interaction site [polypeptide binding]; other site 671143007881 RodZ interaction site [polypeptide binding]; other site 671143007882 rod shape-determining protein MreC; Provisional; Region: PRK13922 671143007883 rod shape-determining protein MreC; Region: MreC; pfam04085 671143007884 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 671143007885 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 671143007886 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 671143007887 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 671143007888 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 671143007889 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 671143007890 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 671143007891 active site 671143007892 HIGH motif; other site 671143007893 nucleotide binding site [chemical binding]; other site 671143007894 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 671143007895 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 671143007896 active site 671143007897 KMSKS motif; other site 671143007898 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 671143007899 tRNA binding surface [nucleotide binding]; other site 671143007900 anticodon binding site; other site 671143007901 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 671143007902 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 671143007903 lipoprotein signal peptidase; Provisional; Region: PRK14787 671143007904 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 671143007905 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 671143007906 RNA binding surface [nucleotide binding]; other site 671143007907 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 671143007908 active site 671143007909 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 671143007910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143007911 active site 671143007912 phosphorylation site [posttranslational modification] 671143007913 intermolecular recognition site; other site 671143007914 dimerization interface [polypeptide binding]; other site 671143007915 sensory histidine kinase CreC; Provisional; Region: PRK11100 671143007916 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143007917 dimerization interface [polypeptide binding]; other site 671143007918 PAS domain S-box; Region: sensory_box; TIGR00229 671143007919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 671143007920 putative active site [active] 671143007921 heme pocket [chemical binding]; other site 671143007922 GAF domain; Region: GAF_3; pfam13492 671143007923 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 671143007924 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 671143007925 metal binding site [ion binding]; metal-binding site 671143007926 active site 671143007927 I-site; other site 671143007928 Methyltransferase domain; Region: Methyltransf_31; pfam13847 671143007929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 671143007930 S-adenosylmethionine binding site [chemical binding]; other site 671143007931 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 671143007932 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 671143007933 hexamer interface [polypeptide binding]; other site 671143007934 ligand binding site [chemical binding]; other site 671143007935 putative active site [active] 671143007936 NAD(P) binding site [chemical binding]; other site 671143007937 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 671143007938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 671143007939 motif II; other site 671143007940 aspartate aminotransferase; Provisional; Region: PRK05957 671143007941 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 671143007942 nucleoside/Zn binding site; other site 671143007943 dimer interface [polypeptide binding]; other site 671143007944 catalytic motif [active] 671143007945 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 671143007946 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 671143007947 endonuclease III; Region: ENDO3c; smart00478 671143007948 minor groove reading motif; other site 671143007949 helix-hairpin-helix signature motif; other site 671143007950 substrate binding pocket [chemical binding]; other site 671143007951 active site 671143007952 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 671143007953 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 671143007954 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 671143007955 FtsX-like permease family; Region: FtsX; pfam02687 671143007956 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 671143007957 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 671143007958 Walker A/P-loop; other site 671143007959 ATP binding site [chemical binding]; other site 671143007960 Q-loop/lid; other site 671143007961 ABC transporter signature motif; other site 671143007962 Walker B; other site 671143007963 D-loop; other site 671143007964 H-loop/switch region; other site 671143007965 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 671143007966 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 671143007967 HlyD family secretion protein; Region: HlyD_3; pfam13437 671143007968 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 671143007969 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 671143007970 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 671143007971 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 671143007972 DNA binding residues [nucleotide binding] 671143007973 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 671143007974 EF-hand domain pair; Region: EF_hand_5; pfam13499 671143007975 Ca2+ binding site [ion binding]; other site 671143007976 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 671143007977 EF-hand domain pair; Region: EF_hand_5; pfam13499 671143007978 Ca2+ binding site [ion binding]; other site 671143007979 Transposase; Region: HTH_Tnp_1; cl17663 671143007980 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 671143007981 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 671143007982 macrolide transporter subunit MacA; Provisional; Region: PRK11578 671143007983 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 671143007984 HlyD family secretion protein; Region: HlyD_3; pfam13437 671143007985 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 671143007986 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 671143007987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 671143007988 active site 671143007989 phosphorylation site [posttranslational modification] 671143007990 intermolecular recognition site; other site 671143007991 dimerization interface [polypeptide binding]; other site 671143007992 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 671143007993 DNA binding site [nucleotide binding] 671143007994 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 671143007995 dimerization interface [polypeptide binding]; other site 671143007996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 671143007997 dimer interface [polypeptide binding]; other site 671143007998 phosphorylation site [posttranslational modification] 671143007999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 671143008000 ATP binding site [chemical binding]; other site 671143008001 Mg2+ binding site [ion binding]; other site 671143008002 G-X-G motif; other site 671143008003 FAD binding domain; Region: FAD_binding_4; pfam01565 671143008004 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 671143008005 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 671143008006 FAD binding domain; Region: FAD_binding_4; pfam01565 671143008007 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 671143008008 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 671143008009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 671143008010 catalytic residue [active]