-- dump date 20140619_024157 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1212765000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1212765000002 Walker A motif; other site 1212765000003 ATP binding site [chemical binding]; other site 1212765000004 Walker B motif; other site 1212765000005 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1212765000006 DnaA box-binding interface [nucleotide binding]; other site 1212765000007 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 1212765000008 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 1212765000009 putative DNA binding surface [nucleotide binding]; other site 1212765000010 dimer interface [polypeptide binding]; other site 1212765000011 beta-clamp/clamp loader binding surface; other site 1212765000012 beta-clamp/translesion DNA polymerase binding surface; other site 1212765000013 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1212765000014 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1212765000015 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1212765000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1212765000017 Walker A/P-loop; other site 1212765000018 ATP binding site [chemical binding]; other site 1212765000019 Q-loop/lid; other site 1212765000020 ABC transporter signature motif; other site 1212765000021 Walker B; other site 1212765000022 D-loop; other site 1212765000023 H-loop/switch region; other site 1212765000024 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1212765000025 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1212765000026 NusG family protein; Region: NusG_myco; TIGR01956 1212765000027 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 1212765000028 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1212765000029 HPr interaction site; other site 1212765000030 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1212765000031 active site 1212765000032 phosphorylation site [posttranslational modification] 1212765000033 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1212765000034 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1212765000035 motif 1; other site 1212765000036 dimer interface [polypeptide binding]; other site 1212765000037 active site 1212765000038 motif 2; other site 1212765000039 motif 3; other site 1212765000040 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1212765000041 anticodon binding site; other site 1212765000042 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1212765000043 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1212765000044 dimer interface [polypeptide binding]; other site 1212765000045 active site 1212765000046 PLD-like domain; Region: PLDc_2; pfam13091 1212765000047 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1212765000048 putative active site [active] 1212765000049 catalytic site [active] 1212765000050 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1212765000051 PLD-like domain; Region: PLDc_2; pfam13091 1212765000052 putative active site [active] 1212765000053 catalytic site [active] 1212765000054 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1212765000055 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1212765000056 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1212765000057 active site 1212765000058 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1212765000059 active site 1212765000060 KMSKS motif; other site 1212765000061 Signal recognition particle GTPase [Intracellular trafficking and secretion]; Region: Ffh; COG0541 1212765000062 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1212765000063 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1212765000064 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1212765000065 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 1212765000066 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1212765000067 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1212765000068 dimer interface [polypeptide binding]; other site 1212765000069 ssDNA binding site [nucleotide binding]; other site 1212765000070 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1212765000071 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1212765000072 replicative DNA helicase; Region: DnaB; TIGR00665 1212765000073 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1212765000074 Walker A motif; other site 1212765000075 ATP binding site [chemical binding]; other site 1212765000076 Walker B motif; other site 1212765000077 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1212765000078 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1212765000079 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1212765000080 NAD(P) binding site [chemical binding]; other site 1212765000081 catalytic residues [active] 1212765000082 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 1212765000083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1212765000084 ATP binding site [chemical binding]; other site 1212765000085 Mg2+ binding site [ion binding]; other site 1212765000086 G-X-G motif; other site 1212765000087 DNA gyrase B; Region: DNA_gyraseB; pfam00204 1212765000088 ATP binding site [chemical binding]; other site 1212765000089 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1212765000090 active site 1212765000091 metal binding site [ion binding]; metal-binding site 1212765000092 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1212765000093 DNA gyrase subunit A; Validated; Region: PRK05560 1212765000094 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1212765000095 CAP-like domain; other site 1212765000096 active site 1212765000097 primary dimer interface [polypeptide binding]; other site 1212765000098 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1212765000099 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1212765000100 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1212765000101 active site 1212765000102 KMSKS motif; other site 1212765000103 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1212765000104 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1212765000105 active site 1212765000106 substrate binding site [chemical binding]; other site 1212765000107 metal binding site [ion binding]; metal-binding site 1212765000108 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1212765000109 G1 box; other site 1212765000110 GTP/Mg2+ binding site [chemical binding]; other site 1212765000111 G2 box; other site 1212765000112 Switch I region; other site 1212765000113 G3 box; other site 1212765000114 Switch II region; other site 1212765000115 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 1212765000116 thymidine kinase; Provisional; Region: PRK04296 1212765000117 Membrane GTPase LepA [Cell envelope biogenesis, outer membrane]; Region: LepA; COG0481 1212765000118 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1212765000119 G1 box; other site 1212765000120 GTP/Mg2+ binding site [chemical binding]; other site 1212765000121 G2 box; other site 1212765000122 Switch I region; other site 1212765000123 G3 box; other site 1212765000124 Switch II region; other site 1212765000125 G4 box; other site 1212765000126 G5 box; other site 1212765000127 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1212765000128 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 1212765000129 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1212765000130 triosephosphate isomerase; Provisional; Region: PRK14565 1212765000131 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1212765000132 substrate binding site [chemical binding]; other site 1212765000133 dimer interface [polypeptide binding]; other site 1212765000134 catalytic triad [active] 1212765000135 phosphoglyceromutase; Provisional; Region: PRK05434 1212765000136 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1212765000137 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1212765000138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1212765000139 AAA domain; Region: AAA_21; pfam13304 1212765000140 Walker A/P-loop; other site 1212765000141 ATP binding site [chemical binding]; other site 1212765000142 Q-loop/lid; other site 1212765000143 ABC transporter signature motif; other site 1212765000144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1212765000145 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1212765000146 ABC transporter signature motif; other site 1212765000147 Walker B; other site 1212765000148 D-loop; other site 1212765000149 H-loop/switch region; other site 1212765000150 TOBE domain; Region: TOBE_2; pfam08402 1212765000151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1212765000152 dimer interface [polypeptide binding]; other site 1212765000153 conserved gate region; other site 1212765000154 putative PBP binding loops; other site 1212765000155 ABC-ATPase subunit interface; other site 1212765000156 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1212765000157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1212765000158 dimer interface [polypeptide binding]; other site 1212765000159 conserved gate region; other site 1212765000160 putative PBP binding loops; other site 1212765000161 ABC-ATPase subunit interface; other site 1212765000162 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1212765000163 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 1212765000164 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1212765000165 S-adenosylmethionine synthetase [Coenzyme metabolism]; Region: MetK; COG0192 1212765000166 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1212765000167 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1212765000168 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1212765000169 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1212765000170 dimer interface [polypeptide binding]; other site 1212765000171 motif 1; other site 1212765000172 active site 1212765000173 motif 2; other site 1212765000174 motif 3; other site 1212765000175 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1212765000176 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1212765000177 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1212765000178 Walker A/P-loop; other site 1212765000179 ATP binding site [chemical binding]; other site 1212765000180 Q-loop/lid; other site 1212765000181 ABC transporter signature motif; other site 1212765000182 Walker B; other site 1212765000183 D-loop; other site 1212765000184 H-loop/switch region; other site 1212765000185 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1212765000186 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1212765000187 Walker A/P-loop; other site 1212765000188 ATP binding site [chemical binding]; other site 1212765000189 Q-loop/lid; other site 1212765000190 ABC transporter signature motif; other site 1212765000191 Walker B; other site 1212765000192 D-loop; other site 1212765000193 H-loop/switch region; other site 1212765000194 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1212765000195 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1212765000196 Zn2+ binding site [ion binding]; other site 1212765000197 Mg2+ binding site [ion binding]; other site 1212765000198 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1212765000199 Zn2+ binding site [ion binding]; other site 1212765000200 Mg2+ binding site [ion binding]; other site 1212765000201 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1212765000202 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1212765000203 active site 1212765000204 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1212765000205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1212765000206 active site 1212765000207 motif I; other site 1212765000208 motif II; other site 1212765000209 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1212765000210 DHH family; Region: DHH; pfam01368 1212765000211 DHHA1 domain; Region: DHHA1; pfam02272 1212765000212 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1212765000213 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1212765000214 nucleotide binding site [chemical binding]; other site 1212765000215 elongation factor Tu; Reviewed; Region: PRK00049 1212765000216 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1212765000217 G1 box; other site 1212765000218 GEF interaction site [polypeptide binding]; other site 1212765000219 GTP/Mg2+ binding site [chemical binding]; other site 1212765000220 Switch I region; other site 1212765000221 G2 box; other site 1212765000222 G3 box; other site 1212765000223 Switch II region; other site 1212765000224 G4 box; other site 1212765000225 G5 box; other site 1212765000226 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1212765000227 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1212765000228 Antibiotic Binding Site [chemical binding]; other site 1212765000229 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1212765000230 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1212765000231 GDP-binding site [chemical binding]; other site 1212765000232 ACT binding site; other site 1212765000233 IMP binding site; other site 1212765000234 S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic...; Region: S15_NS1_EPRS_RNA-bind; cl00349 1212765000235 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1212765000236 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1212765000237 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1212765000238 23S rRNA interface [nucleotide binding]; other site 1212765000239 L7/L12 interface [polypeptide binding]; other site 1212765000240 putative thiostrepton binding site; other site 1212765000241 L25 interface [polypeptide binding]; other site 1212765000242 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1212765000243 mRNA/rRNA interface [nucleotide binding]; other site 1212765000244 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1212765000245 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1212765000246 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000247 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000248 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1212765000249 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000250 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1212765000251 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000252 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1212765000253 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1212765000254 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1212765000255 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 1212765000256 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1212765000257 active site 1212765000258 HIGH motif; other site 1212765000259 nucleotide binding site [chemical binding]; other site 1212765000260 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1212765000261 active site 1212765000262 KMSKS motif; other site 1212765000263 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1212765000264 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1212765000265 NAD binding site [chemical binding]; other site 1212765000266 dimer interface [polypeptide binding]; other site 1212765000267 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1212765000268 substrate binding site [chemical binding]; other site 1212765000269 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1212765000270 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1212765000271 active site 1212765000272 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1212765000273 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1212765000274 HIGH motif; other site 1212765000275 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1212765000276 active site 1212765000277 KMSKS motif; other site 1212765000278 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1212765000279 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1212765000280 Zn2+ binding site [ion binding]; other site 1212765000281 Mg2+ binding site [ion binding]; other site 1212765000282 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 1212765000283 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1212765000284 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 1212765000285 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1212765000286 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1212765000287 Walker A/P-loop; other site 1212765000288 ATP binding site [chemical binding]; other site 1212765000289 Q-loop/lid; other site 1212765000290 ABC transporter signature motif; other site 1212765000291 Walker B; other site 1212765000292 D-loop; other site 1212765000293 H-loop/switch region; other site 1212765000294 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1212765000295 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1212765000296 Walker A/P-loop; other site 1212765000297 ATP binding site [chemical binding]; other site 1212765000298 Q-loop/lid; other site 1212765000299 ABC transporter signature motif; other site 1212765000300 Walker B; other site 1212765000301 D-loop; other site 1212765000302 H-loop/switch region; other site 1212765000303 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1212765000304 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1212765000305 ABC-ATPase subunit interface; other site 1212765000306 dimer interface [polypeptide binding]; other site 1212765000307 putative PBP binding regions; other site 1212765000308 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1212765000309 ABC-ATPase subunit interface; other site 1212765000310 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1212765000311 dimer interface [polypeptide binding]; other site 1212765000312 putative PBP binding regions; other site 1212765000313 Predicted flavoprotein [General function prediction only]; Region: COG0431 1212765000314 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1212765000315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1212765000316 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1212765000317 active site 1212765000318 motif I; other site 1212765000319 motif II; other site 1212765000320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1212765000321 motif II; other site 1212765000322 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1212765000323 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1212765000324 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1212765000325 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1212765000326 active site 1212765000327 HIGH motif; other site 1212765000328 nucleotide binding site [chemical binding]; other site 1212765000329 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1212765000330 active site 1212765000331 KMSKS motif; other site 1212765000332 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1212765000333 tRNA binding surface [nucleotide binding]; other site 1212765000334 anticodon binding site; other site 1212765000335 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1212765000336 DHH family; Region: DHH; pfam01368 1212765000337 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1212765000338 active site 1212765000339 HIGH motif; other site 1212765000340 nucleotide binding site [chemical binding]; other site 1212765000341 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1212765000342 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1212765000343 active site 1212765000344 KMSKS motif; other site 1212765000345 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1212765000346 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 1212765000347 Aspartyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AspS; COG0173 1212765000348 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1212765000349 Dimer interface [polypeptide binding]; other site 1212765000350 anticodon binding site; other site 1212765000351 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1212765000352 motif 1; other site 1212765000353 dimer interface [polypeptide binding]; other site 1212765000354 active site 1212765000355 motif 2; other site 1212765000356 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1212765000357 active site 1212765000358 motif 3; other site 1212765000359 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1212765000360 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1212765000361 dimer interface [polypeptide binding]; other site 1212765000362 motif 1; other site 1212765000363 active site 1212765000364 motif 2; other site 1212765000365 motif 3; other site 1212765000366 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1212765000367 anticodon binding site; other site 1212765000368 CTP synthetase; Validated; Region: pyrG; PRK05380 1212765000369 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1212765000370 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1212765000371 active site 1212765000372 putative oxyanion hole; other site 1212765000373 catalytic triad [active] 1212765000374 GTP1/OBG; Region: GTP1_OBG; pfam01018 1212765000375 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 1212765000376 Ribosome-binding factor A; Region: RBFA; cl00542 1212765000377 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1212765000378 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1212765000379 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1212765000380 G1 box; other site 1212765000381 putative GEF interaction site [polypeptide binding]; other site 1212765000382 GTP/Mg2+ binding site [chemical binding]; other site 1212765000383 Switch I region; other site 1212765000384 G2 box; other site 1212765000385 G3 box; other site 1212765000386 Switch II region; other site 1212765000387 G4 box; other site 1212765000388 G5 box; other site 1212765000389 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1212765000390 Translation-initiation factor 2; Region: IF-2; pfam11987 1212765000391 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1212765000392 transcription termination factor NusA; Region: NusA; TIGR01953 1212765000393 NusA N-terminal domain; Region: NusA_N; pfam08529 1212765000394 NusA-like KH domain; Region: KH_5; pfam13184 1212765000395 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1212765000396 G-X-X-G motif; other site 1212765000397 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1212765000398 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1212765000399 rRNA interaction site [nucleotide binding]; other site 1212765000400 S8 interaction site; other site 1212765000401 putative laminin-1 binding site; other site 1212765000402 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1212765000403 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1212765000404 active site 1212765000405 (T/H)XGH motif; other site 1212765000406 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 1212765000407 CAAX protease self-immunity; Region: Abi; pfam02517 1212765000408 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 1212765000409 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1212765000410 active site 1212765000411 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1212765000412 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1212765000413 conserved cys residue [active] 1212765000414 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1212765000415 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1212765000416 dimer interface [polypeptide binding]; other site 1212765000417 putative anticodon binding site; other site 1212765000418 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1212765000419 motif 1; other site 1212765000420 dimer interface [polypeptide binding]; other site 1212765000421 active site 1212765000422 motif 2; other site 1212765000423 motif 3; other site 1212765000424 DNA polymerase III DnaE; Validated; Region: dnaE; PRK05898 1212765000425 5'-3' exonuclease; Region: 53EXOc; smart00475 1212765000426 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1212765000427 active site 1212765000428 metal binding site 1 [ion binding]; metal-binding site 1212765000429 putative 5' ssDNA interaction site; other site 1212765000430 metal binding site 3; metal-binding site 1212765000431 metal binding site 2 [ion binding]; metal-binding site 1212765000432 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1212765000433 putative DNA binding site [nucleotide binding]; other site 1212765000434 putative metal binding site [ion binding]; other site 1212765000435 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cl00352 1212765000436 putative active site [active] 1212765000437 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1212765000438 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1212765000439 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1212765000440 dimer interface [polypeptide binding]; other site 1212765000441 putative radical transfer pathway; other site 1212765000442 diiron center [ion binding]; other site 1212765000443 tyrosyl radical; other site 1212765000444 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; pfam07972 1212765000445 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1212765000446 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1212765000447 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1212765000448 active site 1212765000449 dimer interface [polypeptide binding]; other site 1212765000450 catalytic residues [active] 1212765000451 effector binding site; other site 1212765000452 R2 peptide binding site; other site 1212765000453 DNA polymerase II large subunit; Provisional; Region: PRK14714 1212765000454 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000455 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1212765000456 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000457 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 1212765000458 mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); Region: 3a0801s09; TIGR00990 1212765000459 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1212765000460 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1212765000461 putative dimer interface [polypeptide binding]; other site 1212765000462 putative anticodon binding site; other site 1212765000463 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1212765000464 motif 1; other site 1212765000465 dimer interface [polypeptide binding]; other site 1212765000466 active site 1212765000467 motif 2; other site 1212765000468 motif 3; other site 1212765000469 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 1212765000470 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1212765000471 nucleotide binding pocket [chemical binding]; other site 1212765000472 K-X-D-G motif; other site 1212765000473 catalytic site [active] 1212765000474 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1212765000475 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1212765000476 Dimer interface [polypeptide binding]; other site 1212765000477 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1212765000478 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1212765000479 Ligand Binding Site [chemical binding]; other site 1212765000480 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1212765000481 motif 1; other site 1212765000482 active site 1212765000483 motif 2; other site 1212765000484 motif 3; other site 1212765000485 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1212765000486 Part of AAA domain; Region: AAA_19; pfam13245 1212765000487 Family description; Region: UvrD_C_2; pfam13538 1212765000488 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1212765000489 Part of AAA domain; Region: AAA_19; pfam13245 1212765000490 Family description; Region: UvrD_C_2; pfam13538 1212765000491 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1212765000492 Part of AAA domain; Region: AAA_19; pfam13245 1212765000493 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1212765000494 Family description; Region: UvrD_C_2; pfam13538 1212765000495 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1212765000496 Part of AAA domain; Region: AAA_19; pfam13245 1212765000497 Family description; Region: UvrD_C_2; pfam13538 1212765000498 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1212765000499 Part of AAA domain; Region: AAA_19; pfam13245 1212765000500 Family description; Region: UvrD_C_2; pfam13538 1212765000501 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13631 1212765000502 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1212765000503 Walker A/P-loop; other site 1212765000504 ATP binding site [chemical binding]; other site 1212765000505 Q-loop/lid; other site 1212765000506 ABC transporter signature motif; other site 1212765000507 Walker B; other site 1212765000508 D-loop; other site 1212765000509 H-loop/switch region; other site 1212765000510 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1212765000511 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 1212765000512 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1212765000513 Walker A/P-loop; other site 1212765000514 ATP binding site [chemical binding]; other site 1212765000515 Q-loop/lid; other site 1212765000516 ABC transporter signature motif; other site 1212765000517 Walker B; other site 1212765000518 D-loop; other site 1212765000519 H-loop/switch region; other site 1212765000520 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1212765000521 Ribosomal protein L28 [Translation, ribosomal structure and biogenesis]; Region: RpmB; COG0227 1212765000522 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1212765000523 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1212765000524 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1212765000525 RNA binding surface [nucleotide binding]; other site 1212765000526 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1212765000527 active site 1212765000528 catalytic site [active] 1212765000529 substrate binding site [chemical binding]; other site 1212765000530 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1212765000531 active site 1212765000532 catalytic site [active] 1212765000533 substrate binding site [chemical binding]; other site 1212765000534 Family of unknown function (DUF633); Region: DUF633; pfam04816 1212765000535 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1212765000536 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1212765000537 active site 1212765000538 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1212765000539 active site 1212765000540 catalytic site [active] 1212765000541 substrate binding site [chemical binding]; other site 1212765000542 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1212765000543 Recombination protein U; Region: RecU; cl01314 1212765000544 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1212765000545 MraW methylase family; Region: Methyltransf_5; cl17771 1212765000546 MraZ protein; Region: MraZ; pfam02381 1212765000547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1212765000548 MraZ protein; Region: MraZ; pfam02381 1212765000549 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 1212765000550 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1212765000551 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1212765000552 active site 1212765000553 catalytic tetrad [active] 1212765000554 Ribosomal protein S9/S16; Region: Ribosomal_S9; pfam00380 1212765000555 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1212765000556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1212765000557 Walker A motif; other site 1212765000558 ATP binding site [chemical binding]; other site 1212765000559 Walker B motif; other site 1212765000560 arginine finger; other site 1212765000561 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1212765000562 Competence protein; Region: Competence; cl00471 1212765000563 ATP synthase A chain; Region: ATP-synt_A; cl00413 1212765000564 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 1212765000565 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1212765000566 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1212765000567 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1212765000568 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 1212765000569 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1212765000570 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1212765000571 Walker A motif; other site 1212765000572 ATP binding site [chemical binding]; other site 1212765000573 Walker B motif; other site 1212765000574 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1212765000575 core domain interface [polypeptide binding]; other site 1212765000576 delta subunit interface [polypeptide binding]; other site 1212765000577 epsilon subunit interface [polypeptide binding]; other site 1212765000578 Protein of unknown function (DUF402); Region: DUF402; cl00979 1212765000579 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1212765000580 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1212765000581 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1212765000582 alpha subunit interaction interface [polypeptide binding]; other site 1212765000583 Walker A motif; other site 1212765000584 ATP binding site [chemical binding]; other site 1212765000585 Walker B motif; other site 1212765000586 inhibitor binding site; inhibition site 1212765000587 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1212765000588 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1212765000589 nucleotide binding site [chemical binding]; other site 1212765000590 substrate binding site [chemical binding]; other site 1212765000591 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 1212765000592 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1212765000593 hinge region; other site 1212765000594 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1212765000595 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1212765000596 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1212765000597 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1212765000598 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1212765000599 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1212765000600 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1212765000601 23S rRNA interface [nucleotide binding]; other site 1212765000602 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1212765000603 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1212765000604 core dimer interface [polypeptide binding]; other site 1212765000605 L11 interface [polypeptide binding]; other site 1212765000606 putative EF-Tu interaction site [polypeptide binding]; other site 1212765000607 putative EF-G interaction site [polypeptide binding]; other site 1212765000608 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 1212765000609 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1212765000610 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1212765000611 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 1212765000612 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 1212765000613 trimerization site [polypeptide binding]; other site 1212765000614 active site 1212765000615 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1212765000616 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1212765000617 GTP/Mg2+ binding site [chemical binding]; other site 1212765000618 G4 box; other site 1212765000619 G1 box; other site 1212765000620 Switch I region; other site 1212765000621 G2 box; other site 1212765000622 G3 box; other site 1212765000623 Switch II region; other site 1212765000624 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1212765000625 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1212765000626 active site 1212765000627 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cl10033 1212765000628 gamma subunit interface [polypeptide binding]; other site 1212765000629 epsilon subunit interface [polypeptide binding]; other site 1212765000630 LBP interface [polypeptide binding]; other site 1212765000631 Phosphotransferase enzyme family; Region: APH; pfam01636 1212765000632 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1212765000633 active site 1212765000634 substrate binding site [chemical binding]; other site 1212765000635 ATP binding site [chemical binding]; other site 1212765000636 GTP-binding protein Der; Reviewed; Region: PRK00093 1212765000637 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1212765000638 G1 box; other site 1212765000639 GTP/Mg2+ binding site [chemical binding]; other site 1212765000640 G2 box; other site 1212765000641 Switch I region; other site 1212765000642 G3 box; other site 1212765000643 Switch II region; other site 1212765000644 G4 box; other site 1212765000645 G5 box; other site 1212765000646 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1212765000647 G1 box; other site 1212765000648 GTP/Mg2+ binding site [chemical binding]; other site 1212765000649 Switch I region; other site 1212765000650 G2 box; other site 1212765000651 G3 box; other site 1212765000652 Switch II region; other site 1212765000653 G4 box; other site 1212765000654 G5 box; other site 1212765000655 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1212765000656 IHF dimer interface [polypeptide binding]; other site 1212765000657 IHF - DNA interface [nucleotide binding]; other site 1212765000658 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1212765000659 IHF dimer interface [polypeptide binding]; other site 1212765000660 IHF - DNA interface [nucleotide binding]; other site 1212765000661 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1212765000662 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000663 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1212765000664 Amino acid permease; Region: AA_permease_2; pfam13520 1212765000665 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1212765000666 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1212765000667 Walker A/P-loop; other site 1212765000668 ATP binding site [chemical binding]; other site 1212765000669 Q-loop/lid; other site 1212765000670 ABC transporter signature motif; other site 1212765000671 Walker B; other site 1212765000672 D-loop; other site 1212765000673 H-loop/switch region; other site 1212765000674 FOG: CBS domain [General function prediction only]; Region: COG0517 1212765000675 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1212765000676 Divalent cation transporter; Region: MgtE; cl00786 1212765000677 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1212765000678 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1212765000679 nucleotide binding site/active site [active] 1212765000680 HIT family signature motif; other site 1212765000681 catalytic residue [active] 1212765000682 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1212765000683 streptomycin interaction site [chemical binding]; other site 1212765000684 23S rRNA interaction site [nucleotide binding]; other site 1212765000685 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1212765000686 16S rRNA interaction site [nucleotide binding]; other site 1212765000687 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 1212765000688 elongation factor G; Reviewed; Region: PRK00007 1212765000689 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1212765000690 G1 box; other site 1212765000691 putative GEF interaction site [polypeptide binding]; other site 1212765000692 GTP/Mg2+ binding site [chemical binding]; other site 1212765000693 Switch I region; other site 1212765000694 G2 box; other site 1212765000695 G3 box; other site 1212765000696 Switch II region; other site 1212765000697 G4 box; other site 1212765000698 G5 box; other site 1212765000699 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1212765000700 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1212765000701 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1212765000702 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 1212765000703 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1212765000704 HSP70 interaction site [polypeptide binding]; other site 1212765000705 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1212765000706 Zn binding sites [ion binding]; other site 1212765000707 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1212765000708 dimer interface [polypeptide binding]; other site 1212765000709 GrpE; Region: GrpE; pfam01025 1212765000710 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1212765000711 dimer interface [polypeptide binding]; other site 1212765000712 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1212765000713 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1212765000714 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1212765000715 intersubunit interface [polypeptide binding]; other site 1212765000716 active site 1212765000717 zinc binding site [ion binding]; other site 1212765000718 Na+ binding site [ion binding]; other site 1212765000719 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1212765000720 TrkA-N domain; Region: TrkA_N; pfam02254 1212765000721 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1212765000722 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1212765000723 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 1212765000724 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1212765000725 active site 1212765000726 GMP synthase; Reviewed; Region: guaA; PRK00074 1212765000727 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1212765000728 conserved cys residue [active] 1212765000729 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1212765000730 ATP Binding subdomain [chemical binding]; other site 1212765000731 Ligand Binding sites [chemical binding]; other site 1212765000732 Dimerization subdomain; other site 1212765000733 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1212765000734 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1212765000735 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1212765000736 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1212765000737 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1212765000738 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1212765000739 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1212765000740 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1212765000741 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1212765000742 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1212765000743 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1212765000744 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1212765000745 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1212765000746 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit; Region: gatB; TIGR00133 1212765000747 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1212765000748 Amidase; Region: Amidase; cl11426 1212765000749 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1212765000750 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1212765000751 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000752 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000753 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1212765000754 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000755 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1212765000756 regulatory protein interface [polypeptide binding]; other site 1212765000757 active site 1212765000758 regulatory phosphorylation site [posttranslational modification]; other site 1212765000759 Ribosomal protein L19; Region: Ribosomal_L19; pfam01245 1212765000760 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 1212765000761 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1212765000762 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1212765000763 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1212765000764 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 1212765000765 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1212765000766 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1212765000767 alphaNTD homodimer interface [polypeptide binding]; other site 1212765000768 alphaNTD - beta interaction site [polypeptide binding]; other site 1212765000769 alphaNTD - beta' interaction site [polypeptide binding]; other site 1212765000770 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1212765000771 30S ribosomal protein S11; Region: bact_S11; TIGR03632 1212765000772 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1212765000773 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1212765000774 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 1212765000775 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1212765000776 RNA binding site [nucleotide binding]; other site 1212765000777 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1212765000778 active site 1212765000779 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1212765000780 SecY translocase; Region: SecY; pfam00344 1212765000781 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1212765000782 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1212765000783 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1212765000784 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1212765000785 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1212765000786 23S rRNA interface [nucleotide binding]; other site 1212765000787 L5 interface [polypeptide binding]; other site 1212765000788 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1212765000789 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1212765000790 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1212765000791 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 1212765000792 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1212765000793 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1212765000794 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1212765000795 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1212765000796 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1212765000797 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1212765000798 RNA binding site [nucleotide binding]; other site 1212765000799 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1212765000800 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 1212765000801 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1212765000802 23S rRNA interface [nucleotide binding]; other site 1212765000803 putative translocon interaction site; other site 1212765000804 signal recognition particle (SRP54) interaction site; other site 1212765000805 L23 interface [polypeptide binding]; other site 1212765000806 trigger factor interaction site; other site 1212765000807 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1212765000808 23S rRNA interface [nucleotide binding]; other site 1212765000809 5S rRNA interface [nucleotide binding]; other site 1212765000810 putative antibiotic binding site [chemical binding]; other site 1212765000811 L25 interface [polypeptide binding]; other site 1212765000812 L27 interface [polypeptide binding]; other site 1212765000813 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1212765000814 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1212765000815 G-X-X-G motif; other site 1212765000816 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1212765000817 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1212765000818 putative translocon binding site; other site 1212765000819 protein-rRNA interface [nucleotide binding]; other site 1212765000820 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 1212765000821 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1212765000822 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1212765000823 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1212765000824 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000825 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1212765000826 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1212765000827 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1212765000828 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1212765000829 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1212765000830 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1212765000831 ATP binding site [chemical binding]; other site 1212765000832 putative Mg++ binding site [ion binding]; other site 1212765000833 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 1212765000834 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1212765000835 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1212765000836 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000837 Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ValS; COG0525 1212765000838 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1212765000839 active site 1212765000840 HIGH motif; other site 1212765000841 nucleotide binding site [chemical binding]; other site 1212765000842 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1212765000843 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1212765000844 active site 1212765000845 KMSKS motif; other site 1212765000846 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1212765000847 anticodon binding site; other site 1212765000848 tRNA binding surface [nucleotide binding]; other site 1212765000849 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 1212765000850 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1212765000851 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1212765000852 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1212765000853 active site 1212765000854 nucleotide binding site [chemical binding]; other site 1212765000855 HIGH motif; other site 1212765000856 KMSKS motif; other site 1212765000857 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1212765000858 tRNA binding surface [nucleotide binding]; other site 1212765000859 anticodon binding site; other site 1212765000860 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1212765000861 RNA/DNA hybrid binding site [nucleotide binding]; other site 1212765000862 active site 1212765000863 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1212765000864 23S rRNA interface [nucleotide binding]; other site 1212765000865 L3 interface [polypeptide binding]; other site 1212765000866 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1212765000867 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1212765000868 V-type ATP synthase subunit I; Validated; Region: PRK05771 1212765000869 endonuclease subunit; Provisional; Region: 46; PHA02562 1212765000870 Orthopoxvirus A26L/A30L protein; Region: Pox_A30L_A26L; cl17524 1212765000871 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1212765000872 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1212765000873 phosphodiesterase; Provisional; Region: PRK12704 1212765000874 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1212765000875 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1212765000876 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1212765000877 Anticodon-binding domain; Region: AD; cl10767 1212765000878 Formin Homology 2 Domain; Region: FH2; pfam02181 1212765000879 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1212765000880 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1212765000881 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1212765000882 RPB11 interaction site [polypeptide binding]; other site 1212765000883 RPB3 interaction site [polypeptide binding]; other site 1212765000884 RPB12 interaction site [polypeptide binding]; other site 1212765000885 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1212765000886 RPB1 interaction site [polypeptide binding]; other site 1212765000887 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1212765000888 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1212765000889 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1212765000890 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1212765000891 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1212765000892 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1212765000893 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1212765000894 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1212765000895 DNA binding site [nucleotide binding] 1212765000896 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1212765000897 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1212765000898 domain interfaces; other site 1212765000899 active site 1212765000900 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1212765000901 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1212765000902 active site 1212765000903 ADP/pyrophosphate binding site [chemical binding]; other site 1212765000904 dimerization interface [polypeptide binding]; other site 1212765000905 allosteric effector site; other site 1212765000906 fructose-1,6-bisphosphate binding site; other site 1212765000907 enolase; Provisional; Region: eno; PRK00077 1212765000908 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1212765000909 dimer interface [polypeptide binding]; other site 1212765000910 metal binding site [ion binding]; metal-binding site 1212765000911 substrate binding pocket [chemical binding]; other site 1212765000912 trigger factor; Region: tig; TIGR00115 1212765000913 ribonuclease R; Region: RNase_R; TIGR02063 1212765000914 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1212765000915 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 1212765000916 nucleotide binding site [chemical binding]; other site 1212765000917 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1212765000918 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1212765000919 tetramer interface [polypeptide binding]; other site 1212765000920 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1212765000921 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1212765000922 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1212765000923 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1212765000924 FtsX-like permease family; Region: FtsX; pfam02687 1212765000925 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1212765000926 translation elongation factor P; Region: efp; TIGR00038 1212765000927 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1212765000928 RNA binding site [nucleotide binding]; other site 1212765000929 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1212765000930 RNA binding site [nucleotide binding]; other site 1212765000931 dUTPase; Region: dUTPase_2; pfam08761 1212765000932 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1212765000933 active site 1212765000934 homodimer interface [polypeptide binding]; other site 1212765000935 metal binding site [ion binding]; metal-binding site 1212765000936 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1212765000937 23S rRNA binding site [nucleotide binding]; other site 1212765000938 L21 binding site [polypeptide binding]; other site 1212765000939 L13 binding site [polypeptide binding]; other site 1212765000940 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1212765000941 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1212765000942 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1212765000943 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1212765000944 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1212765000945 ATP binding site [chemical binding]; other site 1212765000946 putative Mg++ binding site [ion binding]; other site 1212765000947 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1212765000948 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1212765000949 nucleotide binding region [chemical binding]; other site 1212765000950 ATP-binding site [chemical binding]; other site 1212765000951 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1212765000952 Putative peptidase (DUF31); Region: DUF31; pfam01732 1212765000953 Putative peptidase (DUF31); Region: DUF31; pfam01732 1212765000954 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 1212765000955 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1212765000956 dimer interface [polypeptide binding]; other site 1212765000957 substrate binding site [chemical binding]; other site 1212765000958 metal binding sites [ion binding]; metal-binding site 1212765000959 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1212765000960 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1212765000961 catalytic residues [active] 1212765000962 hypothetical protein; Provisional; Region: PRK09609 1212765000963 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1212765000964 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1212765000965 motif 1; other site 1212765000966 dimer interface [polypeptide binding]; other site 1212765000967 active site 1212765000968 motif 2; other site 1212765000969 motif 3; other site 1212765000970 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1212765000971 anticodon binding site; other site 1212765000972 DNA primase, catalytic core; Region: dnaG; TIGR01391 1212765000973 CHC2 zinc finger; Region: zf-CHC2; cl17510 1212765000974 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1212765000975 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1212765000976 active site 1212765000977 metal binding site [ion binding]; metal-binding site 1212765000978 interdomain interaction site; other site 1212765000979 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 1212765000980 RuvA N terminal domain; Region: RuvA_N; pfam01330 1212765000981 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1212765000982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1212765000983 Walker A motif; other site 1212765000984 ATP binding site [chemical binding]; other site 1212765000985 Walker B motif; other site 1212765000986 arginine finger; other site 1212765000987 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1212765000988 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1212765000989 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000990 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000991 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1212765000992 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1212765000993 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1212765000994 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1212765000995 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1212765000996 interface (dimer of trimers) [polypeptide binding]; other site 1212765000997 Substrate-binding/catalytic site; other site 1212765000998 Zn-binding sites [ion binding]; other site 1212765000999 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1212765001000 motif 1; other site 1212765001001 dimer interface [polypeptide binding]; other site 1212765001002 active site 1212765001003 motif 2; other site 1212765001004 motif 3; other site 1212765001005 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1212765001006 anticodon binding site; other site 1212765001007 oligoendopeptidase F; Region: pepF; TIGR00181 1212765001008 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1212765001009 Zn binding site [ion binding]; other site 1212765001010 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1212765001011 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1212765001012 TMP-binding site; other site 1212765001013 ATP-binding site [chemical binding]; other site 1212765001014 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1212765001015 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1212765001016 Walker A motif; other site 1212765001017 ATP binding site [chemical binding]; other site 1212765001018 Walker B motif; other site 1212765001019 tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334 1212765001020 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1212765001021 active site 1212765001022 nucleotide binding site [chemical binding]; other site 1212765001023 HIGH motif; other site 1212765001024 KMSKS motif; other site 1212765001025 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1212765001026 tRNA binding surface [nucleotide binding]; other site 1212765001027 anticodon binding site; other site 1212765001028 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1212765001029 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1212765001030 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1212765001031 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 1212765001032 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1212765001033 Hpr binding site; other site 1212765001034 active site 1212765001035 homohexamer subunit interaction site [polypeptide binding]; other site 1212765001036 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1212765001037 Phosphoglycerate kinase; Region: PGK; pfam00162 1212765001038 substrate binding site [chemical binding]; other site 1212765001039 hinge regions; other site 1212765001040 ADP binding site [chemical binding]; other site 1212765001041 catalytic site [active] 1212765001042 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1212765001043 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1212765001044 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1212765001045 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1212765001046 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cl00482 1212765001047 RNB domain; Region: RNB; pfam00773 1212765001048 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1212765001049 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1212765001050 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1212765001051 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1212765001052 AP (apurinic/apyrimidinic) site pocket; other site 1212765001053 DNA interaction; other site 1212765001054 Metal-binding active site; metal-binding site 1212765001055 FGAM-synthase; Provisional; Region: PHA03366 1212765001056 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1212765001057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1212765001058 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1212765001059 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1212765001060 putative active site [active] 1212765001061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1212765001062 Walker A/P-loop; other site 1212765001063 ATP binding site [chemical binding]; other site 1212765001064 Q-loop/lid; other site 1212765001065 ABC transporter signature motif; other site 1212765001066 Walker B; other site 1212765001067 D-loop; other site 1212765001068 H-loop/switch region; other site 1212765001069 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl17885 1212765001070 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1212765001071 active site turn [active] 1212765001072 phosphorylation site [posttranslational modification] 1212765001073 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1212765001074 active site turn [active] 1212765001075 phosphorylation site [posttranslational modification] 1212765001076 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1212765001077 Zn2+ binding site [ion binding]; other site 1212765001078 Mg2+ binding site [ion binding]; other site 1212765001079 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1212765001080 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1212765001081 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1212765001082 PCRF domain; Region: PCRF; pfam03462 1212765001083 RF-1 domain; Region: RF-1; pfam00472 1212765001084 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1212765001085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1212765001086 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 1212765001087 Walker A motif; other site 1212765001088 ATP binding site [chemical binding]; other site 1212765001089 Walker B motif; other site 1212765001090 arginine finger; other site 1212765001091 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1212765001092 active site 1212765001093 DNA topoisomerase I; Validated; Region: PRK05582 1212765001094 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1212765001095 active site 1212765001096 metal binding site [ion binding]; metal-binding site 1212765001097 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1212765001098 domain I; other site 1212765001099 DNA binding groove [nucleotide binding] 1212765001100 phosphate binding site [ion binding]; other site 1212765001101 domain II; other site 1212765001102 domain III; other site 1212765001103 nucleotide binding site [chemical binding]; other site 1212765001104 catalytic site [active] 1212765001105 domain IV; other site 1212765001106 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1212765001107 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1212765001108 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1212765001109 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1212765001110 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1212765001111 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1212765001112 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1212765001113 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1212765001114 seryl-tRNA synthetase; Provisional; Region: PRK05431 1212765001115 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1212765001116 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1212765001117 motif 1; other site 1212765001118 dimer interface [polypeptide binding]; other site 1212765001119 active site 1212765001120 motif 2; other site 1212765001121 motif 3; other site 1212765001122 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1212765001123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1212765001124 Walker A motif; other site 1212765001125 ATP binding site [chemical binding]; other site 1212765001126 Walker B motif; other site 1212765001127 arginine finger; other site 1212765001128 Peptidase family M41; Region: Peptidase_M41; pfam01434 1212765001129 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1212765001130 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1212765001131 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1212765001132 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399